interleukin-6 receptor binding

Definition

Target type: molecularfunction

Binding to an interleukin-6 receptor. [GOC:ai]

Interleukin-6 receptor (IL-6R) binding is a crucial step in the signaling pathway of interleukin-6 (IL-6), a pleiotropic cytokine involved in a wide range of biological processes including inflammation, immune response, and hematopoiesis. The molecular function of IL-6R binding involves a series of events that initiate the downstream signaling cascade.

IL-6 binds to its cognate receptor, IL-6R, which is a transmembrane protein expressed on the surface of various cells. This binding event triggers a conformational change in the IL-6R, leading to the recruitment of another transmembrane protein called gp130. gp130 serves as a signal transducer and is essential for the activation of the IL-6 signaling pathway.

The formation of the IL-6/IL-6R/gp130 complex initiates a cascade of intracellular events. The cytoplasmic domains of gp130 undergo dimerization, bringing together two Janus kinase (JAK) proteins. JAKs are tyrosine kinases that are activated upon dimerization. Once activated, JAKs phosphorylate gp130 on specific tyrosine residues.

These phosphorylated tyrosine residues serve as docking sites for signal transducer and activator of transcription (STAT) proteins, specifically STAT1, STAT3, and STAT5. STAT proteins bind to the phosphorylated tyrosine residues on gp130 and are subsequently phosphorylated by JAKs.

Phosphorylated STAT proteins dimerize and translocate from the cytoplasm to the nucleus. In the nucleus, the STAT dimers bind to specific DNA sequences called STAT binding elements, activating the transcription of target genes. These target genes encode proteins involved in various biological processes, including inflammation, immune response, cell growth, and differentiation.

Therefore, the molecular function of IL-6 receptor binding involves a series of events that lead to the activation of the IL-6 signaling pathway. This pathway ultimately results in the transcription of target genes involved in a wide range of biological processes.'
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Proteins (5)

Compounds (554)