ATPase binding

Definition

Target type: molecularfunction

Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. [GOC:ai]

ATPase binding is a molecular function that describes the interaction of a protein with ATP (adenosine triphosphate), a key energy currency in cells. This interaction is crucial for numerous cellular processes, including:
1. **Energy Transduction:** ATPases harness the energy stored in the phosphate bonds of ATP to drive various cellular processes, such as muscle contraction, active transport of molecules across membranes, and DNA replication.
2. **Molecular Motor Function:** ATPases often act as molecular motors, converting chemical energy from ATP hydrolysis into mechanical work. For example, myosin ATPases are essential for muscle contraction, while kinesin and dynein ATPases move vesicles and organelles along microtubules.
3. **Signal Transduction:** ATPases are involved in signal transduction pathways, where they act as molecular switches, responding to specific stimuli by hydrolyzing ATP and altering their conformation, thus triggering downstream signaling events.
4. **Regulation of Cellular Processes:** ATPases play critical roles in regulating various cellular processes, including gene expression, cell division, and cell death.
5. **Protein Folding:** ATPases are involved in the folding and unfolding of proteins, ensuring proper protein structure and function.
6. **Maintenance of Cellular Integrity:** ATPases are essential for maintaining cellular integrity, by transporting ions, nutrients, and waste products across membranes, and by regulating cell volume.

The binding of ATP to an ATPase typically occurs at a specific site within the protein, often involving multiple amino acid residues. The interaction between the ATPase and ATP is highly specific, ensuring that ATP is hydrolyzed only when it is bound to the appropriate enzyme. The hydrolysis of ATP to ADP (adenosine diphosphate) and inorganic phosphate releases energy, which is then utilized to drive the associated cellular process.'
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Proteins (24)

Compounds (865)