clemizole

Description

Clemizole is a histamine H1 receptor antagonist that was originally developed as an antihistamine. It has also been shown to have anticholinergic and antiemetic effects. Clemizole is synthesized via a multi-step process involving the reaction of 2-chloro-N-(2-dimethylaminoethyl)benzamide with 1-phenyl-1-propanol. The compound exhibits a high affinity for the H1 receptor, blocking the binding of histamine and thus preventing its effects. Research into Clemizole has focused on its potential therapeutic applications in conditions such as allergic rhinitis, urticaria, and motion sickness. However, it has not been widely used clinically due to its potential for side effects, including drowsiness, dry mouth, and blurred vision. Further research is needed to explore the therapeutic potential of Clemizole and to optimize its safety profile.'

clemizole: was heading 1966-94 (see under BENZIMIDAZOLES 1966-90); use BENZIMIDAZOLES to search CLEMIZOLE 1966-94; a histamine H1- blocker used to treat allergies [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

clemizole : A member of the class of benzimidazoles that is 1H-benzimidazole substituted by a pyrrolidin-1-ylmethyl and a 4-chlorobenzyl groups at positions 2 and 1 respectively. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]