Caries, Cervical

Dental caries involving the tooth root, cementum, or cervical area of the tooth.

Synonym
Caries, Root
Root Caries
Cervical Caries
Caries, Cervical

Excerpt	Reference
"Root caries is a problem of importance among dentate elderly."	( Jones, JA, 1995)
"The mechanism of root caries is thought to be mediated by both bacterial and mammalian proteases produced by plaque and the periodontal tissues, respectively."	( Bosko, C; Evans, RT; Golub, LM; Gwinnett, AJ; McNamara, TF; Ramamurthy, NS; Schroeder, KL, 1998)
"Root caries is a widespread problem and can be quite serious in older populations."	( Baysan, A; Lynch, E, 2001)
"The prevalence of root caries is increasing."	( Keltjens, HM; Schaeken, MJ; van der Hoeven, JS, 1992)
"Root caries is the predominant disease of the tooth tissues in the elderly population and differs in progression and micromorphology from coronal dentin caries."	( Arnold, WH; Bietau, V; Gaengler, P; Renner, PO, 2007)
"Root caries is common in institutionalized elders, and effective prevention methods are needed."	( Corbet, EF; Dyson, JE; Lo, EC; Luo, Y; Tan, HP, 2010)
"Prevention of root caries is favored by toothpaste with 5,000 ppm F and by fluoride rinsing with 0."	( Petersson, LG, 2013)
"Prevention of root caries is favorable with higher fluoride concentrations in, e."	( Petersson, LG, 2013)
"Root caries is prevalent in elderly disabled nursing home residents in Denmark."	( Ekstrand, KR; Ellwood, RP; Hede, B; Poulsen, JE; Qvist, V; Twetman, S, 2013)
"Root caries is a major cause of tooth loss in older adults, and tooth loss is the most significant negative impact on oral health-related quality of life for the elderly."	( Gregory, D; Hyde, S, 2015)
"Root caries is difficult to repair because of the complex aetiology and dentine structure."	( Burrow, MF; Cai, J; Manton, DJ; Palamara, JEA; Sobh, EG; Tsuda, Y, 2019)
"The increase in root caries is a serious problem as society ages."	( Awazu, K; Hazama, H; Kondo, S; Mine, A; Okumura, S; Tanimoto, H; Tomioka, Y; Yamaguchi, S; Yamamoto, K; Yasuo, K; Yoshikawa, K, 2022)

Excerpt	Reference
"The incidence of root caries has been found to increase as the population ages and as edentulism becomes less prevalent due to improved dental awareness and care, and as exposure of roots due to gingival recession has also increased in the elderly."	( Bosko, C; Evans, RT; Golub, LM; Gwinnett, AJ; McNamara, TF; Ramamurthy, NS; Schroeder, KL, 1998)

Excerpt	Reference
"Untreated root caries, plaque score, and counts of lactobacilli increased between the ages of 88 and 92 years (P < 0."	( Birkhed, D; Emilson, CG; Lundgren, M; Osterberg, T; Steen, B; Steen, G, 1997)
"The effect of triclosan on root caries and on the survival of dental crowns (fixed dental prosthetic treatment) has not been evaluated."	( DeVizio, W; Garcia, L; Mann, J; Stewart, B; Vered, Y; Zhang, YP; Zini, A, 2009)
"Therapeutic approaches for root caries without risk of pulp exposure can be categorized into non-invasive and restorative treatment."	( Burrow, MF; Cai, J; Manton, DJ; Palamara, J, 2018)
"Non-invasive treatment of root caries lesions (RCLs) may impact oral health-related quality of life (OHRQoL), but no evidence is available."	( Correa-Beltrán, G; Giacaman, RA; Hugo, FN; León, S; Payero, S; Rivera, M, 2019)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	87 (32.22)	12.5806
2000's	80 (29.63)	18.1394
2010's	70 (25.93)	28.8240
2020's	33 (12.22)	9.53

Drug	Relationship Strength	Studies	Trials
acetic acid	medium	5	1
acetone	low	2	0
ammonium hydroxide	medium	1	1
benzyl alcohol	medium	2	1
formic acid	low	1	0
citric acid, anhydrous	low	1	0
chlorine	medium	1	1
gallic acid	low	2	0
lactic acid	low	7	0
hydrogen carbonate	medium	1	1
phosphoric acid	low	2	0
phosphorylcholine	low	2	0
aluminum fluoride	low	1	0
aspirin	low	1	0
cetylpyridinium	low	1	0
erythrosine	low	3	0
etidronate	low	1	0
glutaral	medium	6	2
potassium iodide	low	3	0
propranolol	low	1	0
resorcinol	low	1	0
sodium fluoride	medium	44	16
risedronic acid	low	1	0
triclosan	medium	3	2
sorbitol	medium	1	1
hydroxyproline	low	2	0
pilocarpine	low	1	0
lysine	medium	1	1
sucrose	medium	9	1
edetic acid	low	1	0
leucine	medium	1	1
arginine	medium	4	2
acrylic acid	low	1	0
methylmethacrylate	low	2	0
rhodamine b	low	1	0
xylitol	medium	8	4
thymol	medium	6	4
quinoline	low	1	0
tolonium chloride	low	1	0
2-naphthol	low	1	0
hexadecylamine	medium	1	1
limestone	medium	1	1
luminol	low	1	0
eosine yellowish-(ys)	low	1	0
lithium carbonate	low	1	0
c.i. 42510	low	1	0
hydroxyethyl methacrylate	low	2	0
durapatite	low	4	0
zinc oxide	low	1	0
bisphenol a-glycidyl methacrylate	low	6	0
fluorescein	low	3	0
olaflur	low	1	0
lanthanum	low	1	0
molybdenum	low	1	0
neodymium	low	1	0
palladium	low	1	0
platinum	low	1	0
silver	low	1	0
titanium	low	3	0
argon	low	4	0
cerium	low	1	0
erbium	low	1	0
zirconium	medium	4	1
calcium phosphate, dibasic, anhydrous	low	2	0
calcium phosphate, monobasic, anhydrous	low	2	0
tricalcium phosphate	medium	13	2
silver nitrate	low	1	0
zinc phosphate	low	1	0
ozone	medium	12	3
ferric sulfate	low	1	0
tricalcium silicate	low	1	0
hexafluorosilicate	low	1	0
fluorides	medium	118	24
tri-n-butylborane	low	1	0
phenyl acetate	medium	4	1
glutamic acid	medium	1	1
piroctone olamine	low	1	0
4-methacryloxyethyltrimellitic acid anhydride	low	1	0
glucose, (beta-d)-isomer	low	1	0
fluorophosphate	medium	9	1
glyceryl methacrylate	low	1	0
fibrinogen	low	1	0
cobalt	low	1	0
procyanidin	medium	10	1
proanthocyanidin	low	6	0
listerine	low	1	0
titanium tetrafluoride	low	1	0
c & b metabond	low	1	0
2-methacryloyloxyethyl phosphorylcholine	low	2	0
calcium pyrophosphate	low	2	0
silver fluoride	low	2	0
glycogen	low	1	0
stevioside	low	1	0
genipin	low	1	0
naringin	low	1	0
cocaine	medium	2	1
iridoids	low	1	0
riboflavin	low	1	0
potassium fluoride	low	1	0
pyrophosphate	low	1	0
silver diammine	medium	1	1
sodium dodecyl sulfate	low	2	0
quercetin	low	1	0
lead	low	1	0
aluminum	low	1	0
strontium	medium	2	1
bismuth	low	1	0
phosphorus	medium	6	1
rebaudioside a	low	1	0
chlorhexidine	medium	27	10
fluorapatite	low	2	0
silicate cement	low	1	0
chitosan	low	1	0
sodium hypochlorite	low	1	0
cardiovascular agents	low	1	0
tetracycline	low	2	0
salicylates	low	1	0
4-des-dimethylaminotetracycline	low	1	0
gluma	medium	4	1
rome	low	1	0
agar	medium	2	1
caseins	medium	7	1
orabase	low	1	0
all-bond 2	low	1	0

Protein Targets (949)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Luciferase	11	0	0	11
RAR-related orphan receptor gamma	18	0	0	18
GLI family zinc finger 3	19	0	0	19
AR protein	22	0	0	22
estrogen receptor 2 (ER beta)	13	0	0	13
nuclear receptor subfamily 1, group I, member 3	11	0	0	11
progesterone receptor	12	0	0	12
retinoic acid nuclear receptor alpha variant 1	23	0	0	23
retinoid X nuclear receptor alpha	15	0	0	15
pregnane X nuclear receptor	15	0	0	15
estrogen nuclear receptor alpha	29	0	0	29
peroxisome proliferator-activated receptor delta	13	0	0	13
aryl hydrocarbon receptor	11	0	0	11
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	15	0	0	15
v-jun sarcoma virus 17 oncogene homolog (avian)	17	0	0	17
Histone H2A.x	12	0	0	12
thyroid hormone receptor beta isoform 2	18	0	0	18
nuclear factor erythroid 2-related factor 2 isoform 1	20	0	0	20
DNA repair and recombination protein RadA	0	0	1	1
Voltage-dependent calcium channel gamma-2 subunit	13	0	0	13
Cellular tumor antigen p53	17	0	0	17
Cytochrome P450 1A2	0	4	0	4
Cytochrome P450 2A6	0	2	1	3
Sulfotransferase 1A1	0	0	0	2
Glutamate receptor 2	13	2	1	16
Cytochrome P450 2A5	0	1	0	1
Sulfotransferase 1E1	0	0	0	1
Sulfotransferase 1A1	0	0	0	1
Sulfotransferase 2A1	0	0	0	1
Free fatty acid receptor 3	0	0	1	1
Free fatty acid receptor 2	0	1	1	2
Tyrosine-protein kinase Lck	0	1	1	2
Tyrosine-protein kinase Fyn	0	0	1	1
Fibrinogen C domain-containing protein 1	0	1	0	1
TDP1 protein	15	0	0	15
glucocorticoid receptor [Homo sapiens]	18	0	0	18
estrogen-related nuclear receptor alpha	21	0	0	21
lamin isoform A-delta10	12	0	0	12
euchromatic histone-lysine N-methyltransferase 2	15	0	0	15
peripheral myelin protein 22	7	0	0	7
Choline O-acetyltransferase	0	1	0	1
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
Chain A, Cruzipain	4	0	0	4
interleukin 8	7	0	0	7
phosphopantetheinyl transferase	8	0	0	8
GLS protein	9	0	0	9
farnesoid X nuclear receptor	14	0	0	14
vitamin D (1,25- dihydroxyvitamin D3) receptor	11	0	0	11
tumor necrosis factor	3	0	0	3
vitamin D3 receptor isoform VDRA	4	0	0	4
Cytochrome P450 3A4	0	3	0	4
Cytochrome P450 2D6	0	3	0	3
Cytochrome P450 2C9	0	3	0	3
Cytochrome P450 2C19	0	2	0	2
Nuclear receptor ROR-gamma	6	0	0	6
Potassium voltage-gated channel subfamily H member 2	0	3	0	3
Aurora kinase B	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	1	3
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	10	0	0	10
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
thioredoxin reductase	9	0	0	9
NFKB1 protein, partial	2	0	0	2
thyroid stimulating hormone receptor	6	0	0	6
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	4	0	0	4
chromobox protein homolog 1	5	0	0	5
flap endonuclease 1	6	0	0	6
DNA polymerase iota isoform a (long)	7	0	0	7
muscarinic acetylcholine receptor M1	3	0	0	3
lethal factor (plasmid)	6	0	0	6
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	2	0	3
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
ATP-dependent phosphofructokinase	6	0	0	6
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	8	0	0	8
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
aldehyde dehydrogenase 1 family, member A1	9	0	0	9
hypothetical protein, conserved	4	0	0	4
cytochrome P450 family 3 subfamily A polypeptide 4	12	0	0	12
EWS/FLI fusion protein	3	0	0	3
cytochrome P450 2D6	8	0	0	8
glucocerebrosidase	3	0	0	3
Rac1 protein	0	0	1	1
IDH1	6	0	0	6
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Bloom syndrome protein isoform 1	5	0	0	5
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	6	0	0	6
DNA polymerase kappa isoform 1	7	0	0	7
Prostaglandin-H2 D-isomerase	0	1	0	1
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	4
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Bile salt export pump	0	5	0	5
Epidermal growth factor receptor	0	2	0	2
Carbonic anhydrase 1	0	13	0	14
Carbonic anhydrase 2	0	14	1	16
Fatty acid-binding protein, liver	0	1	0	1
Integrin beta-3	4	1	1	6
Myeloperoxidase	0	2	0	2
Prostaglandin G/H synthase 1	0	1	1	2
Seed linoleate 13S-lipoxygenase-1	0	2	0	4
Integrin alpha-IIb	4	1	1	6
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Adenosine receptor A1	0	3	0	3
Adenosine receptor A2a	0	3	0	3
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	3	0	3
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	5	2	1	8
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	4	1	5
Sigma non-opioid intracellular receptor 1	0	0	1	1
acetylcholinesterase	11	0	0	11
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Spike glycoprotein	8	0	1	9
Chain A, Beta-lactamase	2	0	0	2
glp-1 receptor, partial	5	0	0	5
hypoxia-inducible factor 1 alpha subunit	9	0	0	9
SMAD family member 2	10	0	0	10
ATAD5 protein, partial	4	0	0	4
SMAD family member 3	10	0	0	10
TSHR protein	2	0	0	2
67.9K protein	5	0	0	5
peroxisome proliferator activated receptor gamma	14	0	0	14
thyroid stimulating hormone receptor	11	0	0	11
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	7	0	0	7
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
heat shock protein beta-1	10	0	0	10
DNA polymerase eta isoform 1	3	0	0	3
geminin	7	0	0	7
Alpha-synuclein	6	3	0	9
ATPase family AAA domain-containing protein 5	6	0	0	6
Ataxin-2	7	0	0	7
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Smad3	4	0	0	4
interferon gamma precursor	0	0	0	2
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
acid sphingomyelinase	2	0	0	2
PAX8	0	0	0	1
15-lipoxygenase, partial	3	0	0	3
pregnane X receptor	1	0	0	1
USP1 protein, partial	5	0	0	5
caspase 7, apoptosis-related cysteine protease	4	0	0	4
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
PINK1	2	0	0	2
G	5	0	0	5
Parkin	3	0	0	3
heat shock protein 90	0	0	1	1
caspase-3	4	0	0	4
calcineurin A1, putative	0	0	1	1
activating transcription factor 6	8	0	0	8
cytochrome P450 2D6 isoform 1	2	0	0	2
hepatocyte nuclear factor 4-alpha isoform 2	0	2	0	2
cellular tumor antigen p53 isoform a	4	0	0	4
cytochrome P450 2C9 precursor	3	0	0	3
perilipin-5	0	2	0	2
thyroid hormone receptor beta isoform a	9	0	0	9
perilipin-1	0	2	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
transcriptional regulator ERG isoform 3	1	0	0	1
huntingtin isoform 2	2	0	0	2
importin subunit beta-1 isoform 1	2	0	0	2
mitogen-activated protein kinase 1	7	0	0	7
ubiquitin-conjugating enzyme E2 N	0	2	0	2
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
protein AF-9 isoform a	0	0	0	2
snurportin-1	2	0	0	2
melanocortin receptor 4	0	1	0	1
CAAX prenyl protease	0	0	0	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
bcl-2-related protein A1	0	2	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
nuclear receptor ROR-gamma isoform 1	4	0	0	4
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	2	0	2
cytochrome P450 3A4 isoform 1	5	0	0	5
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	2
bcl-2-like protein 11 isoform 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	5	1	1	7
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 1	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	1	0	4
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Glutathione reductase, mitochondrial	0	7	0	9
Interferon beta	5	0	0	5
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
72 kDa type IV collagenase	0	4	0	4
Matrix metalloproteinase-9	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	5	1	1	7
Gamma-aminobutyric acid receptor subunit delta	5	1	1	7
Gamma-aminobutyric acid receptor subunit gamma-2	5	1	1	7
Gamma-aminobutyric acid receptor subunit alpha-5	5	1	1	7
Gamma-aminobutyric acid receptor subunit alpha-3	5	1	1	7
Gamma-aminobutyric acid receptor subunit gamma-1	5	1	1	7
Gamma-aminobutyric acid receptor subunit alpha-2	5	1	1	7
Gamma-aminobutyric acid receptor subunit alpha-4	5	1	1	7
Gamma-aminobutyric acid receptor subunit gamma-3	5	1	1	7
Trypanothione reductase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	5	1	1	7
Histamine H2 receptor	4	0	0	4
Gamma-aminobutyric acid receptor subunit beta-3	5	1	1	7
Gamma-aminobutyric acid receptor subunit beta-2	5	1	1	7
TAR DNA-binding protein 43	4	0	0	4
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
GABA theta subunit	5	1	1	7
Inositol hexakisphosphate kinase 1	5	0	0	5
Multidrug and toxin extrusion protein 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	5	1	1	7
Spermine oxidase	0	1	0	1
cytochrome P450 2C9, partial	5	0	0	5
Carbonic anhydrase 4	0	9	0	9
Carbonic anhydrase	0	6	0	6
Carbonic anhydrase 15	0	5	0	5
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Beta-lactamase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	3	0	3
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	1	0	2
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	2	0	2
Alpha-ketoglutarate-dependent dioxygenase FTO	0	2	0	2
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Amyloid-beta precursor protein	0	4	0	4
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	3	0	4
5-hydroxytryptamine receptor 2C	0	2	0	2
Tryptophan 5-hydroxylase 1	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
D	0	1	0	1
5-hydroxytryptamine receptor 1A	0	4	1	6
Alpha-2B adrenergic receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	1	1	2
Alpha-2A adrenergic receptor	0	1	1	2
Liver carboxylesterase 1	0	0	0	1
Sodium-dependent noradrenaline transporter	0	2	1	3
Sodium-dependent dopamine transporter	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
5-hydroxytryptamine receptor 1B	0	3	0	3
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Sodium-dependent serotonin transporter	0	4	0	4
Sodium-dependent serotonin transporter	0	3	0	4
5-hydroxytryptamine receptor 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	1	4
5-hydroxytryptamine receptor 3A	0	1	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	1	4
Glutamate receptor ionotropic, NMDA 2B	0	3	1	4
Glutamate receptor ionotropic, NMDA 2C	0	3	1	4
Sodium-dependent dopamine transporter	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	3	1	4
5-hydroxytryptamine receptor 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	3	1	4
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Leukotriene B4 receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	3	1	4
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Transporter	0	2	0	2
Eyes absent homolog 2	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
Chain A, ATP-DEPENDENT DNA HELICASE Q1	6	0	0	6
Genome polyprotein	0	1	1	2
chaperonin-containing TCP-1 beta subunit homolog	3	0	0	3
Fumarate hydratase	5	0	0	5
thioredoxin glutathione reductase	2	0	0	2
polyprotein	5	0	0	5
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
thyrotropin-releasing hormone receptor	5	0	0	5
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
eyes absent homolog 2 isoform a	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
histone acetyltransferase KAT2A isoform 1	7	0	0	7
relaxin receptor 1 isoform 1	1	0	0	1
Flavin reductase (NADPH)	0	0	1	1
large T antigen	0	1	0	1
apical membrane antigen 1, AMA1	1	0	0	1
Type IV secretion-like conjugative transfer relaxase protein TraI	0	1	0	1
Chain A, Ferritin light chain	3	0	0	3
Microtubule-associated protein tau	5	0	0	5
fructose-bisphosphate aldolase A	1	0	0	1
glyceraldehyde-3-phosphate dehydrogenase isoform 1	1	0	0	1
survival motor neuron protein isoform d	3	0	0	3
Carbonic anhydrase 12	0	3	0	3
Pancreatic triacylglycerol lipase	0	2	0	2
Urokinase-type plasminogen activator	0	2	0	2
Tissue-type plasminogen activator	0	1	0	1
Plasminogen activator inhibitor 1	0	1	0	1
Urokinase-type plasminogen activator	0	1	0	1
Carbonic anhydrase 3	0	3	0	3
Matrilysin	0	1	0	1
L-selectin	0	1	0	1
P-selectin	0	1	0	1
E-selectin	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	2	0	2
Carbonic anhydrase 6	0	3	0	3
Dipeptidyl peptidase 4	0	2	0	2
Proteasome subunit beta type-5	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	5	0	5
Carbonic anhydrase 7	0	3	0	3
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6	0	1	0	1
Squalene monooxygenase	0	1	0	1
Autoinducer 2-binding periplasmic protein LuxP	0	1	0	1
Anthrax toxin receptor 2	0	2	0	2
Disintegrin and metalloproteinase domain-containing protein 17	1	1	0	2
Lactoperoxidase	0	1	0	2
Polypeptide N-acetylgalactosaminyltransferase 2	0	1	1	2
Alpha-(1,3)-fucosyltransferase 7	0	1	0	1
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1	0	1	0	1
Carbonic anhydrase 9	0	6	1	7
Carbonic anhydrase	0	2	0	2
Reverse transcriptase/RNaseH	0	1	0	1
Carbonic anhydrase 13	0	3	0	3
Toll-like receptor 2	0	1	0	1
Carbonic anhydrase 14	0	3	0	3
Carbonic anhydrase 5B, mitochondrial	0	3	0	3
arylsulfatase A	4	0	0	4
Tyrosine-protein phosphatase non-receptor type 2	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	3	0	3
Tyrosine-protein phosphatase non-receptor type 11	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Asialoglycoprotein receptor 1	0	1	1	2
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
regulator of G-protein signaling 4	3	0	0	3
beta-2 adrenergic receptor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	1	2	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	1	0	1
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Proton-coupled amino acid transporter 1	0	2	0	3
Amino acid transporter	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
NEDD8-activating enzyme E1 regulatory subunit isoform a	0	1	0	1
NEDD8-conjugating enzyme Ubc12	0	1	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Queuine tRNA-ribosyltransferase	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
PPM1D protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
luciferase	1	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
caspase-9 isoform alpha precursor	0	1	0	1
histone deacetylase 9 isoform 3	3	0	0	3
pyruvate kinase PKM isoform a	1	0	0	1
DNA polymerase beta	2	0	0	2
caspase-3 isoform a preproprotein	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
Vpr	2	0	0	2
muscleblind-like protein 1 isoform 1	2	0	0	2
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
neuropeptide S receptor isoform A	2	0	0	2
Glutathione reductase	0	1	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Albumin	0	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	3	1	4
Alpha-1B adrenergic receptor	0	4	1	5
Amine oxidase [flavin-containing] A	0	2	0	2
Alpha-1D adrenergic receptor	0	3	1	4
Cruzipain	0	1	0	1
Alpha-1A adrenergic receptor	0	3	1	4
Guanine nucleotide-binding protein G	1	0	0	1
Inositol monophosphatase 1	3	0	0	3
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
phosphoglycerate kinase	2	0	0	2
Aromatase	0	2	0	2
G protein-activated inward rectifier potassium channel 2	0	0	1	1
G protein-activated inward rectifier potassium channel 4	0	0	1	1
G protein-activated inward rectifier potassium channel 1	0	0	1	1
Heparanase	0	0	1	1
Sodium/iodide cotransporter	0	1	0	1
Ornithine transcarbamylase, mitochondrial	0	1	0	1
2-dehydropantoate 2-reductase	0	1	0	1
Nociceptin receptor	0	1	0	1
Fe(3+)-Zn(2+) purple acid phosphatase	0	1	0	1
Muscarinic acetylcholine receptor M2	0	3	2	5
Muscarinic acetylcholine receptor M3	0	2	0	3
Muscarinic acetylcholine receptor M4	0	2	0	3
Muscarinic acetylcholine receptor M5	0	2	0	3
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M2	0	2	0	3
Muscarinic acetylcholine receptor M1	0	2	3	5
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Cytochrome P450 2A13	0	1	1	2
Beta-1 adrenergic receptor	0	1	1	3
D(1A) dopamine receptor	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Bile salt export pump	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Albumin	0	0	1	1
Beta-2 adrenergic receptor	0	2	1	3
ATP-dependent translocase ABCB1	0	3	1	4
Beta-1 adrenergic receptor	0	2	1	3
5-hydroxytryptamine receptor 1A	0	1	1	2
Alpha-2A adrenergic receptor	0	1	2	4
Adenosine receptor A3	0	2	1	3
Beta-2 adrenergic receptor	0	2	0	3
Cytochrome P450 2C8	0	2	0	2
Beta-3 adrenergic receptor	0	2	1	3
D(2) dopamine receptor	0	1	1	2
Alpha-2B adrenergic receptor	0	0	1	2
Beta-1 adrenergic receptor	0	2	1	4
Alpha-2C adrenergic receptor	0	1	2	4
D(3) dopamine receptor	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	1	2
D(1A) dopamine receptor	0	1	1	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Alpha-1D adrenergic receptor	0	0	1	2
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
5-hydroxytryptamine receptor 2A	0	2	1	3
5-hydroxytryptamine receptor 2C	0	2	1	3
Adenosine receptor A2a	0	1	1	2
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
5-hydroxytryptamine receptor 7	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	2	4
Alpha-1B adrenergic receptor	0	0	1	2
Mu-type opioid receptor	0	1	1	2
Vasopressin V1a receptor	0	1	1	2
Delta-type opioid receptor	0	1	1	2
Kappa-type opioid receptor	0	1	1	2
5-hydroxytryptamine receptor 2B	0	2	1	3
5-hydroxytryptamine receptor 6	0	2	1	3
5-hydroxytryptamine receptor 7	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Beta-2 adrenergic receptor	0	1	1	3
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Chain A, dATP pyrophosphohydrolase	0	1	0	1
Chain A, Adenylate cyclase type 5	0	1	0	1
Chain B, Adenylate cyclase type 2	0	1	0	1
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, APH(2')-Id	0	1	0	1
glucose-6-phosphate dehydrogenase	0	1	0	1
Nrf2	1	0	0	1
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
DNA polymerase III, partial	1	0	0	1
Neuraminidase	0	2	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
hexokinase	0	1	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
galactokinase	1	0	0	1
peripheral myelin protein 22 isoform 1	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
Transmembrane protease serine 2	0	0	1	1
Polyphenol oxidase 2	0	3	0	6
Maltase-glucoamylase, intestinal	0	1	0	1
NUAK family SNF1-like kinase 1	0	1	0	1
Lysine-specific histone demethylase 1A	0	1	0	1
B2 bradykinin receptor	0	1	0	1
G2/mitotic-specific cyclin-B2	0	1	0	1
Arginase	0	1	0	1
Prothrombin	0	1	0	1
Cationic trypsin	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Chymotrypsin-like elastase family member 1	0	1	0	1
Beta-lactamase	0	1	0	1
Protein E6	0	1	0	1
Neuraminidase	0	1	0	1
Interstitial collagenase	0	1	1	2
Phospholipase A2	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Cytochrome P450 1A1	0	2	1	3
Beta-lactamase	0	1	0	1
Cyclin-dependent kinase 1	0	1	0	1
Glycogen phosphorylase, liver form	0	1	0	1
Epoxide hydrolase 1	0	1	0	1
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Procathepsin L	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Tyrosine-protein kinase Yes	0	1	0	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	1	0	1
Insulin-like growth factor 1 receptor	0	1	0	1
Neutrophil elastase	0	2	0	2
Stromelysin-1	0	2	0	2
Hepatocyte growth factor receptor	0	1	0	1
Heterogeneous nuclear ribonucleoprotein A1	0	0	1	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	2	0	2
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	3	1	4
Calmodulin-1	0	1	0	1
Replicase polyprotein 1ab	0	3	1	4
Alpha-amylase 1A	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Sialidase	0	1	0	1
Malate dehydrogenase	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 2	0	1	0	1
Serine/threonine-protein kinase pim-1	0	1	1	2
Cyclin-dependent kinase 4	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Sucrase-isomaltase, intestinal	0	1	0	1
G2/mitotic-specific cyclin-B1	0	1	0	1
Tyrosinase	0	2	0	2
Urease subunit alpha	0	2	0	2
Serine/threonine-protein kinase B-raf	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
G2/mitotic-specific cyclin-B	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Chymotrypsinogen B	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX12	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
Casein kinase II subunit alpha'	0	2	0	2
Amine oxidase [flavin-containing] A	0	1	0	1
5'-nucleotidase	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Acetylcholinesterase	0	1	0	1
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
G1/S-specific cyclin-D1	0	1	0	1
Cyclin-dependent kinase 2	0	1	0	1
C-X-C chemokine receptor type 1	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Phosphatidylinositol 3-kinase regulatory subunit alpha	0	1	0	1
Cytosol aminopeptidase	0	1	0	1
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	0	1	0	1
Vasopressin V2 receptor	0	1	0	1
Tyrosine-protein kinase receptor UFO	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
RAC-alpha serine/threonine-protein kinase	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	2	0	2
Trypsin-3	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Receptor-type tyrosine-protein kinase FLT3	0	1	0	1
17-beta-hydroxysteroid dehydrogenase type 2	0	1	0	1
Macrophage metalloelastase	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Glutathione reductase	0	1	0	1
Tyrosine-protein kinase SYK	0	1	1	2
Collagenase 3	0	2	0	2
1-deoxy-D-xylulose 5-phosphate reductoisomerase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
Glycogen synthase kinase-3 alpha	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
C-C chemokine receptor type 4	0	1	0	1
Serine/threonine-protein kinase Nek2	0	1	0	1
Oligo-1,6-glucosidase IMA1	0	1	0	1
Serine/threonine-protein kinase PLK1	0	1	0	1
Death-associated protein kinase 1	0	1	0	1
Mitogen-activated protein kinase 10	0	1	0	1
Monocarboxylate transporter 1	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Beta-secretase 1	0	2	0	2
Casein kinase II subunit beta	0	2	0	2
Casein kinase II subunit alpha	0	2	0	2
Urease subunit beta	0	2	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	0	3
Cyclin-dependent kinase 6	0	1	0	1
Cyclin-dependent-like kinase 5	0	1	0	1
Heat shock factor protein 1	0	1	0	1
Sorbitol dehydrogenase	0	1	0	1
Cyclin homolog	0	1	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 1	0	1	0	1
Lactoylglutathione lyase	0	2	0	2
Focal adhesion kinase 1	0	1	0	1
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	1	0	1
ELAV-like protein 3	0	1	0	1
Cyclin-dependent kinase 5 activator 1	0	1	0	1
ELAV-like protein 1	0	1	0	1
Serine/threonine-protein kinase N1	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Cytochrome P450 1B1	0	2	1	3
Probable maltase-glucoamylase 2	0	1	0	1
Carbonic anhydrase 3	0	2	0	2
Monocarboxylate transporter 2	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Substance-K receptor	0	1	0	1
Integrase	0	2	0	2
Casein kinase II subunit alpha 3	0	2	0	2
Inositol polyphosphate multikinase	0	1	0	1
G2/mitotic-specific cyclin-B3	0	1	0	1
Aldo-keto reductase family 1 member C21	0	2	0	2
Enoyl-acyl-carrier protein reductase	0	4	0	4
3-oxoacyl-acyl-carrier protein reductase	0	1	0	1
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)	0	1	0	1
Chymotrypsin-C	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Cyclin-dependent kinase 1	0	1	0	1
Phosphodiesterase	0	1	0	1
G-protein coupled receptor 35	0	1	1	2
Serine/threonine-protein kinase Nek6	0	1	0	1
NADPH oxidase 4	0	1	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	1	0	1
Dipeptidyl peptidase 3	0	1	0	1
Inositol hexakisphosphate kinase 2	0	1	0	1
Short transient receptor potential channel 5	0	1	0	1
ALK tyrosine kinase receptor	0	1	0	1
Sialidase-2	0	1	0	1
Neutrophil cytosol factor 1	0	1	0	1
Nicotinamide N-methyltransferase	0	1	0	1
Chain A, Bacterial regulatory proteins, tetR family	0	0	1	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain H, Immunoglobulin Igg1 Heavy chain	0	0	1	1
Chain L, Immunoglobulin Igg1 Lambda Light Chain	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain C, DODECIN	0	0	1	1
Chain E, DODECIN	0	0	1	1
NPYLR7B	0	0	1	1
caspase-1 isoform alpha precursor	1	0	0	1
Riboflavin-binding protein	0	1	1	2
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Caspase-7	1	0	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Butyrophilin subfamily 3 member A1	0	0	1	1
4-hydroxy-3-methylbut-2-enyl diphosphate reductase	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	2	0	2
Farnesyl pyrophosphate synthase	0	2	0	2
Farnesyl pyrophosphate synthase	0	2	0	2
Farnesyl diphosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
H	0	1	0	1
Phosphotransferase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
Peroxisome proliferator-activated receptor alpha	1	0	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Carbonic anhydrase	0	1	0	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Neutrophil collagenase	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Chain A, ODORANT-BINDING PROTEIN	0	1	0	1
Chain A, ODORANT-BINDING PROTEIN	0	1	0	1
Chain B, Odorant-binding Protein	0	1	0	1
Chain A, ODORANT-BINDING PROTEIN	0	1	0	1
Chain A, ODORANT-BINDING PROTEIN	0	1	0	1
Chain A, ODORANT-BINDING PROTEIN	0	1	0	1
Acetylcholinesterase	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Cholinesterase	0	1	0	1
Secreted chorismate mutase	0	1	0	1
Heat sensitive channel TRPV3	0	0	1	1
Transient receptor potential cation channel subfamily A member 1	0	1	1	2
Transient receptor potential cation channel subfamily M member 8	0	1	1	2
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, Repressor	0	0	1	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
Transthyretin	0	1	1	2
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Endoplasmic reticulum chaperone BiP	0	1	0	1
Carbonyl reductase [NADPH] 1	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI	0	2	0	2
Enoyl-acyl carrier reductase	0	1	0	1
Enoyl-ACP reductase II	0	1	0	1
heat shock protein 90, putative	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(4)

Research Excerpts

Overview

Context

Treatment

Research

Studies (270)

Protein Targets (949)

Caries, Cervical

Synonyms(4)

Research Excerpts

Overview

Context

Treatment

Research

Studies (270)

Drugs Studied (140)

Protein Targets (949)