An agonist at the transient receptor potential vanilloid 4 (TRPV4).
ChEBI ID: 140061
| Member | Definition | Class |
|---|---|---|
| gsk 1016790a | A tertiary carboxamide that is piperazine in which one of the amino groups has undergone condensation with the carboxy group of N-[(2,4-dichlorophenyl)sulfonyl]-L-serine, while the other has undergone condensation with the carboxy group of N-(1-benzothiophen-2-ylcarbonyl)-L-leucine. It is a cell-permeable, potent and selective agonist of the TRPV4 (transient receptor potential vanilloid 4) channel. | GSK1016790A |
| phorbol-12,13-didecanoate, (1ar-(1aalpha,1bbeta,4aalpha,7aalpha,7balpha,8alpha,9beta,9aalpha))-isomer | A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted to the corresponding decanoate esters. A Trpv4-specific ligand. | 4alpha-phorbol 12,13-didecanoate |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 5 (29.41) | 24.3611 |
| 2020's | 7 (41.18) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (5.88%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 16 (94.12%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 22.8465 | 4 | 4 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 37.2212 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 46.6128 | 1 | 3 |
| polyprotein | Zika virus | Potency | 37.2212 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 46.6128 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 17-beta-hydroxysteroid dehydrogenase type 2 | Homo sapiens (human) | EC50 | 0.0490 | 1 | 1 |
| Estradiol 17-beta-dehydrogenase 2 | Mus musculus (house mouse) | EC50 | 0.0490 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 4 | Homo sapiens (human) | EC50 | 0.0490 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 4 | Mus musculus (house mouse) | EC50 | 2.6720 | 5 | 5 |