Compounds > tricin 4'-o-(threo-beta-guaiacylglyceryl) ether
Page last updated: 2024-11-13

tricin 4'-o-(threo-beta-guaiacylglyceryl) ether

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Description

tricin 4'-O-(threo-beta-guaiacylglyceryl) ether: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

(-)-(7''S,8''S)-4'',5,7-trihydroxy-3',3'',5'-trimethoxy-4',8''-oxyflavonolignan-7'',9''-diol : A flavonolignan isolated from the stems of Sinocalamus affinis. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
Sinocalamusgenus[no description available]PoaceaeA large family of narrow-leaved herbaceous grasses of the order Cyperales, subclass Commelinidae, class Liliopsida (monocotyledons). Food grains (EDIBLE GRAIN) come from members of this family. RHINITIS, ALLERGIC, SEASONAL can be induced by POLLEN of many of the grasses.[MeSH]

Cross-References

ID SourceID
PubMed CID21575482
CHEMBL ID1224894
CHEBI ID67643
MeSH IDM000594426

Synonyms (11)

Synonym
salcolin b
CHEMBL1224894
chebi:67643 ,
2-(4-{[(1s,2s)-1,3-dihydroxy-1-(4-hydroxy-3-methoxyphenyl)propan-2-yl]oxy}-3,5-dimethoxyphenyl)-5,7-dihydroxy-4h-chromen-4-one
(-)-(7''s,8''s)-4'',5,7-trihydroxy-3',3'',5'-trimethoxy-4',8''-oxyflavonolignan-7'',9''-diol
tricin 4'-o-(threo-beta-guaiacylglyceryl) ether
Q27136114
DTXSID401318363
salcolin a
369390-51-2
2-[4-[(1s,2s)-1,3-dihydroxy-1-(4-hydroxy-3-methoxyphenyl)propan-2-yl]oxy-3,5-dimethoxyphenyl]-5,7-dihydroxychromen-4-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (5)

ClassDescription
flavonolignanAny lignan condensed with a 2-aryl-1-benzopyran skeleton and its substituted derivatives.
dimethoxybenzeneAny methoxybenzene that consists of a benzene skeleton substituted with two methoxy groups and its derivatives.
polyphenolMembers of the class of phenols that contain 2 or more benzene rings each of which is substituted by at least one hydroxy group.
primary alcoholA primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.
secondary alcoholA secondary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (17)

Assay IDTitleYearJournalArticle
AID603444Cytotoxicity against human MCF7 cells at 10 uM after 96 hrs by MTT assay2011Journal of natural products, May-27, Volume: 74, Issue:5
Lignans and neolignans from Sinocalamus affinis and their absolute configurations.
AID504306Antioxidant activity assessed as hydroxyl radical scavenging activity by chemiluminescence analysis2010Journal of natural products, Sep-24, Volume: 73, Issue:9
Antioxidant and anti-inflammatory phenylpropanoid derivatives from Calamus quiquesetinervius.
AID504309Cytotoxicity against mouse RAW264.7 cells assessed as cell viability upto 100 uM by MTS assay2010Journal of natural products, Sep-24, Volume: 73, Issue:9
Antioxidant and anti-inflammatory phenylpropanoid derivatives from Calamus quiquesetinervius.
AID603441Hepatoprotective activity against DL-galactosamine-induced cell damage in rat WB-F344 cells at 10 uM after 24 hrs by MTT assay2011Journal of natural products, May-27, Volume: 74, Issue:5
Lignans and neolignans from Sinocalamus affinis and their absolute configurations.
AID603446Cytotoxicity against human Ketr3 cells at 10 uM after 96 hrs by MTT assay2011Journal of natural products, May-27, Volume: 74, Issue:5
Lignans and neolignans from Sinocalamus affinis and their absolute configurations.
AID603439Inhibition of LPS-induced nitric oxide production in C57BL/6J mouse peritoneal macrophages at 10 uM after 24 hrs by Griess reaction2011Journal of natural products, May-27, Volume: 74, Issue:5
Lignans and neolignans from Sinocalamus affinis and their absolute configurations.
AID504308Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production after 24 hrs2010Journal of natural products, Sep-24, Volume: 73, Issue:9
Antioxidant and anti-inflammatory phenylpropanoid derivatives from Calamus quiquesetinervius.
AID504310Cytotoxicity against LPS-stimulated mouse RAW264.7 cells assessed as cell viability upto 100 uM by MTS assay2010Journal of natural products, Sep-24, Volume: 73, Issue:9
Antioxidant and anti-inflammatory phenylpropanoid derivatives from Calamus quiquesetinervius.
AID603442Cytotoxicity against human A549 cells at 10 uM after 96 hrs by MTT assay2011Journal of natural products, May-27, Volume: 74, Issue:5
Lignans and neolignans from Sinocalamus affinis and their absolute configurations.
AID603437Antiviral activity against HIV1 NL4-3 infected in human 293T cells assessed as inhibition of viral replication at 10 uM after 48 hrs by luciferase reporter gene assay2011Journal of natural products, May-27, Volume: 74, Issue:5
Lignans and neolignans from Sinocalamus affinis and their absolute configurations.
AID603443Cytotoxicity against human BGC823 cells at 10 uM after 96 hrs by MTT assay2011Journal of natural products, May-27, Volume: 74, Issue:5
Lignans and neolignans from Sinocalamus affinis and their absolute configurations.
AID603447Cytotoxicity against human HCT8 cells at 10 uM after 96 hrs by MTT assay2011Journal of natural products, May-27, Volume: 74, Issue:5
Lignans and neolignans from Sinocalamus affinis and their absolute configurations.
AID504305Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by ELISA reader2010Journal of natural products, Sep-24, Volume: 73, Issue:9
Antioxidant and anti-inflammatory phenylpropanoid derivatives from Calamus quiquesetinervius.
AID504307Antioxidant activity assessed as superoxide radical scavenging activity by chemiluminescence analysis2010Journal of natural products, Sep-24, Volume: 73, Issue:9
Antioxidant and anti-inflammatory phenylpropanoid derivatives from Calamus quiquesetinervius.
AID603440Antioxidant activity in rat Liver microsome assessed as inhibition of Fe2+-cystine-induced lipid peroxidation at 10 uM2011Journal of natural products, May-27, Volume: 74, Issue:5
Lignans and neolignans from Sinocalamus affinis and their absolute configurations.
AID603438Neuroprotective activity against serum deprivation-induced toxicity in rat PC12 cells assessed as increase in cell viability at 10 uM after 48 hrs by MTT assay2011Journal of natural products, May-27, Volume: 74, Issue:5
Lignans and neolignans from Sinocalamus affinis and their absolute configurations.
AID603445Cytotoxicity against human Bel7402 cells at 10 uM after 96 hrs by MTT assay2011Journal of natural products, May-27, Volume: 74, Issue:5
Lignans and neolignans from Sinocalamus affinis and their absolute configurations.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (100.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.26

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.26 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index5.21 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.26)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
[no description available]		2.0510chromanol;
monocarboxylic acid;
phenols		antioxidant;
ferroptosis inhibitor;
neuroprotective agent;
radical scavenger;
Wnt signalling inhibitor
lignans
Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)		2.1110
quercetin
[no description available]		2.05107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
tricin
tricin: from Spartina cynosuroides and other plants; structure		2.11103'-methoxyflavones;
dimethoxyflavone;
trihydroxyflavone		EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Anasarca
[description not available]		02.110
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		02.110