| Assay ID | Title | Year | Journal | Article |
|---|
| AID1623857 | Inhibition of CHK1 phosphorylation at S345 in human MCF7 cells at 10 uM pretreated for 30 mins followed by 10 J/m'2 irradiation and measured after 1 hr by Western blot analysis | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. |
| AID1623881 | Cytotoxicity against human MCF7 cells assessed as combination index measured at ED90 at H2O2/pcm ratio of 0.625:1 in presence of H2O2 after 48 hrs by MTT assay | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. |
| AID1623814 | Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. |
| AID750063 | Antiadipogenic activity in mouse 3T3L1 cells assessed as differentiation of preadipocytes to adipocytes after 8 days by spectrophotometry | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11
| Anti-adipogenic activity of compounds isolated from Idesia polycarpa on 3T3-L1 cells. |
| AID1623875 | Antioxidant activity in rat liver microsomes assessed as reduction in lipid peroxidation | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. |
| AID1623858 | Inhibition of CHK2 phosphorylation at T68 in human MCF7 cells at 10 uM pretreated for 30 mins followed by 10 J/m'2 irradiation and measured after 1 hr by Western blot analysis | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. |
| AID1623817 | Cytotoxicity against human NCI-H661 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. |
| AID1623818 | Cytotoxicity against human HaCaT cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. |
| AID290547 | Antitumor activity against KB cells by MTT assay | 2007 | Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10
| Synthesis and biological evaluation of 12 allenic aromatic ethers. |
| AID729537 | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay | 2013 | Bioorganic & medicinal chemistry, Mar-15, Volume: 21, Issue:6
| Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV. |
| AID729536 | Inhibition of human carbonic anhydrase 7 preincubated for 15 mins by CO2 hydration stopped-flow assay | 2013 | Bioorganic & medicinal chemistry, Mar-15, Volume: 21, Issue:6
| Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV. |
| AID358235 | Cytotoxicity against human Raji cells assessed as cell viability at 500 molar ratio by Trypan blue method | 2001 | Journal of natural products, Oct, Volume: 64, Issue:10
| New phenylpropanoid esters of sucrose from Polygonum lapathifolium. |
| AID358232 | Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells at 100 molar ratio relative to TPA | 2001 | Journal of natural products, Oct, Volume: 64, Issue:10
| New phenylpropanoid esters of sucrose from Polygonum lapathifolium. |
| AID729535 | Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration stopped-flow assay | 2013 | Bioorganic & medicinal chemistry, Mar-15, Volume: 21, Issue:6
| Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV. |
| AID1683066 | Anti-inflammatory activity in murine RAW264.7 cells assessed as inhibition of LPS-induced NO production at 50 uM relative to control | 2021 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 31 | A new sesquineolignan and four new neolignans isolated from the leaves of Piper betle, a traditional medicinal plant in Myanmar. |
| AID1623882 | Stability in MeOH and H2O2 by HPLC-PDA assay | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. |
| AID358237 | Cytotoxicity against human Raji cells assessed as cell viability at 10 molar ratio by Trypan blue method | 2001 | Journal of natural products, Oct, Volume: 64, Issue:10
| New phenylpropanoid esters of sucrose from Polygonum lapathifolium. |
| AID379190 | Cytotoxicity against human Hep3B cells after 3 days by MTT method | 2006 | Journal of natural products, Nov, Volume: 69, Issue:11
| Cytotoxic triterpenoids from the leaves of Microtropis fokienensis. |
| AID377979 | Antimutagenic activity in Salmonella Typhimurium TA100 assessed as inhibition of ethyl methanesulfonate-induced mutation at 82.5 uM treated for 30 mins and measured after 2 days by modified Ames test | 1999 | Journal of natural products, Jan, Volume: 62, Issue:1
| Structure-antimutagenic activity relationship study of plicatin B. |
| AID379193 | Cytotoxicity against human A549 cells after 3 days by MTT method | 2006 | Journal of natural products, Nov, Volume: 69, Issue:11
| Cytotoxic triterpenoids from the leaves of Microtropis fokienensis. |
| AID1623820 | Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. |
| AID358852 | Antiproliferative activity against mouse Colon 26-L5 cells by MTT assay | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3
| Six new diarylheptanoids from the seeds of Alpinia blepharocalyx. |
| AID290548 | Antitumor activity against KBv200 cells by MTT assay | 2007 | Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10
| Synthesis and biological evaluation of 12 allenic aromatic ethers. |
| AID729538 | Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay | 2013 | Bioorganic & medicinal chemistry, Mar-15, Volume: 21, Issue:6
| Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV. |
| AID1623876 | Cytotoxicity against human MCF7 cells assessed as combination index measured at ED50 at H2O2/pcm ratio of 1.25:1 in presence of H2O2 after 48 hrs by MTT assay | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. |
| AID1623883 | Drug metabolism assessed as methyl 3-(1-hydroxy-4-oxocyclohexa-2,5-dienyl)acrylate formation by reverse phase-HPLC and HPLC-MS analysis based Fenton reaction assay | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. |
| AID358236 | Cytotoxicity against human Raji cells assessed as cell viability at 100 molar ratio by Trypan blue method | 2001 | Journal of natural products, Oct, Volume: 64, Issue:10
| New phenylpropanoid esters of sucrose from Polygonum lapathifolium. |
| AID1099188 | Antimicrobial activity against Pythium sp. assessed as growth inhibition at 10 ppm by agar dilution method | 1996 | Bioscience, biotechnology, and biochemistry, May, Volume: 60, Issue:5
| Synthesis and antifungal activity of cinnamic acid esters. |
| AID1623813 | Cytotoxicity against mouse L5178B1 cells transfected with pHa MDR1/A retrovirus assessed as reduction in cell viability after 72 hrs by MTT assay | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. |
| AID358231 | Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells at 500 molar ratio relative to TPA | 2001 | Journal of natural products, Oct, Volume: 64, Issue:10
| New phenylpropanoid esters of sucrose from Polygonum lapathifolium. |
| AID1623863 | Cytotoxicity against human MCF7 cells assessed as combination index measured at ED50 at H2O2/pcm ratio of 2.5:1 in presence of H2O2 after 48 hrs by MTT assay | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. |
| AID1611950 | Inhibition of human tyrosinase after 120 mins | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Inhibitors of Melanogenesis: An Updated Review. |
| AID1623862 | Antioxidant activity assessed as hydroxyl radical scavenging activity by measuring inhibition of damage to 2-deoxy-D-ribose after 3 mins by TBA-based Fenton reaction assay | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. |
| AID1191126 | Binding affinity to Pseudomonas aeruginosa recombinant his6-tagged PqsD expressed in Escherichia coli BL21 (lambdaDE3) using AcoA as substrate at 250 to 500 uM incubated for 40 mins prior to compound addition followed by wash out for 30 mins by SPR analys | 2015 | European journal of medicinal chemistry, Jan-27, Volume: 90 | Catechol-based substrates of chalcone synthase as a scaffold for novel inhibitors of PqsD. |
| AID729533 | Inhibition of human carbonic anhydrase 14 preincubated for 15 mins by CO2 hydration stopped-flow assay | 2013 | Bioorganic & medicinal chemistry, Mar-15, Volume: 21, Issue:6
| Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV. |
| AID377976 | Antimutagenic activity in Salmonella Typhimurium TA100 assessed as inhibition of ethyl methanesulfonate-induced mutation at 7.8 uM treated for 30 mins and measured after 2 days by modified Ames test | 1999 | Journal of natural products, Jan, Volume: 62, Issue:1
| Structure-antimutagenic activity relationship study of plicatin B. |
| AID358234 | Cytotoxicity against human Raji cells assessed as cell viability at 1000 molar ratio by Trypan blue method | 2001 | Journal of natural products, Oct, Volume: 64, Issue:10
| New phenylpropanoid esters of sucrose from Polygonum lapathifolium. |
| AID1623878 | Cytotoxicity against human MCF7 cells assessed as combination index measured at ED90 at H2O2/pcm ratio of 1.25:1 in presence of H2O2 after 48 hrs by MTT assay | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. |
| AID144377 | Ability to induce NAD(P)H quinone reductase activity in cultured Hepa 1c1c7 murine hepatoma cells. | 1998 | Journal of medicinal chemistry, Dec-17, Volume: 41, Issue:26
| Chemoprotective properties of phenylpropenoids, bis(benzylidene)cycloalkanones, and related Michael reaction acceptors: correlation of potencies as phase 2 enzyme inducers and radical scavengers. |
| AID1623864 | Cytotoxicity against human MCF7 cells assessed as combination index measured at ED75 at H2O2/pcm ratio of 2.5:1 in presence of H2O2 after 48 hrs by MTT assay | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. |
| AID379191 | Cytotoxicity against human MCF7 cells after 3 days by MTT method | 2006 | Journal of natural products, Nov, Volume: 69, Issue:11
| Cytotoxic triterpenoids from the leaves of Microtropis fokienensis. |
| AID1099186 | Antimicrobial activity against Athelia rolfsii assessed as growth inhibition at 100 ppm by agar dilution method | 1996 | Bioscience, biotechnology, and biochemistry, May, Volume: 60, Issue:5
| Synthesis and antifungal activity of cinnamic acid esters. |
| AID729534 | Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assay | 2013 | Bioorganic & medicinal chemistry, Mar-15, Volume: 21, Issue:6
| Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV. |
| AID736009 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by microplate reader | 2013 | Journal of natural products, Feb-22, Volume: 76, Issue:2
| Flavone tetraglycosides and benzyl alcohol glycosides from the Mongolian medicinal plant Dracocephalum ruyschiana. |
| AID1623865 | Cytotoxicity against human MCF7 cells assessed as combination index measured at ED90 at H2O2/pcm ratio of 2.5:1 in presence of H2O2 after 48 hrs by MTT assay | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. |
| AID1623880 | Cytotoxicity against human MCF7 cells assessed as combination index measured at ED75 at H2O2/pcm ratio of 0.625:1 in presence of H2O2 after 48 hrs by MTT assay | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. |
| AID1191124 | Inhibition of Pseudomonas aeruginosa recombinant PqsD expressed in Escherichia coli BL21 (lambdaDE3) using ACoA/beta-ketodecanoic acid as substrate at 50 uM after 10 mins | 2015 | European journal of medicinal chemistry, Jan-27, Volume: 90 | Catechol-based substrates of chalcone synthase as a scaffold for novel inhibitors of PqsD. |
| AID1099189 | Antimicrobial activity against Pythium sp. assessed as growth inhibition at 100 ppm by agar dilution method | 1996 | Bioscience, biotechnology, and biochemistry, May, Volume: 60, Issue:5
| Synthesis and antifungal activity of cinnamic acid esters. |
| AID358230 | Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells at 1000 molar ratio relative to TPA | 2001 | Journal of natural products, Oct, Volume: 64, Issue:10
| New phenylpropanoid esters of sucrose from Polygonum lapathifolium. |
| AID379189 | Cytotoxicity against human Hep G2 cells after 3 days by MTT method | 2006 | Journal of natural products, Nov, Volume: 69, Issue:11
| Cytotoxic triterpenoids from the leaves of Microtropis fokienensis. |
| AID1623879 | Cytotoxicity against human MCF7 cells assessed as combination index measured at ED50 at H2O2/pcm ratio of 0.625:1 in presence of H2O2 after 48 hrs by MTT assay | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. |
| AID1623821 | Cytotoxicity against human SiHa cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. |
| AID358853 | Antiproliferative activity against human HT1080 cells by MTT assay | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3
| Six new diarylheptanoids from the seeds of Alpinia blepharocalyx. |
| AID1623819 | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. |
| AID1623816 | Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. |
| AID1623877 | Cytotoxicity against human MCF7 cells assessed as combination index measured at ED75 at H2O2/pcm ratio of 1.25:1 in presence of H2O2 after 48 hrs by MTT assay | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. |
| AID1191128 | Inhibition of Pseudomonas aeruginosa PA14 PqsH transposon mutant assessed as extracellular level of HHQ at 250 uM after 16 hrs | 2015 | European journal of medicinal chemistry, Jan-27, Volume: 90 | Catechol-based substrates of chalcone synthase as a scaffold for novel inhibitors of PqsD. |
| AID1717711 | Inhibition of tyrosinase in neonatal human epidermal melanocytes | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22
| Advances in the Design of Genuine Human Tyrosinase Inhibitors for Targeting Melanogenesis and Related Pigmentations. |
| AID1623812 | Cytotoxicity against mouse L5178 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. |
| AID1623815 | Cytotoxicity against human NCI-H460/R cells transfected with MDR assessed as reduction in cell viability after 72 hrs by MTT assay | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. |
| AID379192 | Cytotoxicity against human MDA-MB-231 cells after 3 days by MTT method | 2006 | Journal of natural products, Nov, Volume: 69, Issue:11
| Cytotoxic triterpenoids from the leaves of Microtropis fokienensis. |
| AID377975 | Antimutagenic activity in Salmonella Typhimurium TA100 assessed as inhibition of ethyl methanesulfonate-induced mutation at 3.9 uM treated for 30 mins and measured after 2 days by modified Ames test | 1999 | Journal of natural products, Jan, Volume: 62, Issue:1
| Structure-antimutagenic activity relationship study of plicatin B. |
| AID358233 | Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells at 10 molar ratio relative to TPA | 2001 | Journal of natural products, Oct, Volume: 64, Issue:10
| New phenylpropanoid esters of sucrose from Polygonum lapathifolium. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |