An enzyme inhibitor that interferes with the action of mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase (EC 3.2.1.114), a key enzyme target in the development of anti-cancer therapies.
| Member | Definition | Class | Studies | Trials |
|---|
| mannostatin a | An amino cyclitol that is cyclopentane substituted by hydroxy groups at positions 1, 2 and 3, by an amino group at positon 4, and by a methylsulfanediyl group at position 5 (the 1R,2R,3R,4S,5R-stereoisomer). It is isolated from the soil bacterium Streptoverticillium verticillium. | methyl sulfide; | 48 | 0 | |
| mannostatin-B | An amino cyclitol that is cyclopentane substituted by hydroxy groups at positions 1, 2 and 3, by an amino group at positon 4, and by a methylsulfinyl group at position 5 (the 1R,2R,3R,4S,5R-stereoisomer). It is isolated from the soil bacterium Streptoverticillium verticillium. | amino cyclitol; | 0 | 0 | |
| swainsonine | An indolizidine alkaloid isolated from the plant Swainsona canescens with three hydroxy substituents at positions 1, 2 and 8. | indolizidine alkaloid | 614 | 7 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| Chain A, Alpha-mannosidase Ii | Drosophila melanogaster (fruit fly) | IC50 | 0.0200 | 1 | 1 |
| Chain A, ALPHA-MANNOSIDASE II | Drosophila melanogaster (fruit fly) | IC50 | 0.0200 | 1 | 1 |
| Chain A, Alpha-mannosidase Ii | Drosophila melanogaster (fruit fly) | IC50 | 0.0200 | 1 | 1 |
| Chain A, alpha-mannosidase II | Drosophila melanogaster (fruit fly) | Ki | 0.0360 | 1 | 1 |
| Chain A, alpha-mannosidase II | Drosophila melanogaster (fruit fly) | Ki | 0.0360 | 1 | 1 |
| Lysosomal alpha-mannosidase | Homo sapiens (human) | IC50 | 6.6867 | 3 | 3 |
| Alpha-mannosidase 2C1 | Rattus norvegicus (Norway rat) | IC50 | 1.7500 | 1 | 1 |
| Mannosyl-oligosaccharide alpha-1,2-mannosidase IA | Drosophila melanogaster (fruit fly) | IC50 | 0.0775 | 1 | 2 |
| Mannosyl-oligosaccharide alpha-1,2-mannosidase IA | Drosophila melanogaster (fruit fly) | Ki | 0.0030 | 1 | 1 |
| Alpha-mannosidase 2 | Drosophila melanogaster (fruit fly) | Ki | 0.0195 | 2 | 2 |
| Alpha-1,2-mannosidase family protein | Bacteroides thetaiotaomicron VPI-5482 | Ki | 9.5000 | 2 | 2 |
| Putative alpha-1,2-mannosidase | Bacteroides thetaiotaomicron VPI-5482 | Ki | 9.5000 | 2 | 2 |
| Alpha-1,2-mannosidase, putative | Bacteroides thetaiotaomicron VPI-5482 | Ki | 9.5000 | 2 | 2 |
| Putative alpha-1,2-mannosidase | Bacteroides thetaiotaomicron VPI-5482 | Ki | 9.5000 | 2 | 2 |
| Putative alpha-1,2-mannosidase | Bacteroides thetaiotaomicron VPI-5482 | Ki | 9.5000 | 2 | 2 |
| Putative alpha-1,2-mannosidase | Bacteroides thetaiotaomicron VPI-5482 | Ki | 9.5000 | 2 | 2 |
| Putative alpha-1,2-mannosidase | Bacteroides thetaiotaomicron VPI-5482 | Ki | 9.5000 | 2 | 2 |
| Glycoside hydrolase family 92 | Bacteroides thetaiotaomicron VPI-5482 | Ki | 9.5000 | 2 | 2 |
| Glycoside hydrolase family 92 | Bacteroides thetaiotaomicron VPI-5482 | Ki | 9.5000 | 2 | 2 |
| Alpha-1,2-mannosidase | Bacteroides thetaiotaomicron VPI-5482 | Ki | 9.5000 | 2 | 2 |
| Putative alpha-1,2-mannosidase | Bacteroides thetaiotaomicron VPI-5482 | Ki | 9.5000 | 2 | 2 |
| Alpha-1,2-mannosidase, putative | Bacteroides thetaiotaomicron VPI-5482 | Ki | 9.5000 | 2 | 2 |
| Putative alpha-1,2-mannosidase | Bacteroides thetaiotaomicron VPI-5482 | Ki | 9.5000 | 2 | 2 |
| Alpha-1,2-mannosidase | Bacteroides thetaiotaomicron VPI-5482 | Ki | 9.5000 | 2 | 2 |
| Alpha-1,2-mannosidase, putative | Bacteroides thetaiotaomicron VPI-5482 | Ki | 9.5000 | 2 | 2 |
| Putative alpha-1,2-mannosidase | Bacteroides thetaiotaomicron VPI-5482 | Ki | 9.5000 | 2 | 2 |
| Putative alpha-1,2-mannosidase | Bacteroides thetaiotaomicron VPI-5482 | Ki | 9.5000 | 2 | 2 |
| Alpha-1,2-mannosidase | Bacteroides thetaiotaomicron VPI-5482 | Ki | 9.5000 | 2 | 2 |
| Putative alpha-1,2-mannosidase | Bacteroides thetaiotaomicron VPI-5482 | Ki | 9.5000 | 2 | 2 |
| Putative alpha-1,2-mannosidase | Bacteroides thetaiotaomicron VPI-5482 | Ki | 9.5000 | 2 | 2 |
| Putative alpha-1,2-mannosidase | Bacteroides thetaiotaomicron VPI-5482 | Ki | 9.5000 | 2 | 2 |
| Putative alpha-1,2-mannosidase | Bacteroides thetaiotaomicron VPI-5482 | Ki | 9.5000 | 2 | 2 |
| Alpha-1,2-mannosidase family protein | Bacteroides thetaiotaomicron VPI-5482 | Ki | 9.5000 | 2 | 2 |
| alpha-1,2-Mannosidase | Glycine max (soybean) | IC50 | 0.4000 | 1 | 1 |