oleuropeic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

oleuropeic acid: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	188320
CHEMBL ID	4796626
MeSH ID	M0376035

Synonyms (9)

Synonym
oleuropeic acid
5027-76-9
(4s)-4-(2-hydroxypropan-2-yl)cyclohexene-1-carboxylic acid
DTXSID20198271
FS-9931
(4s)-4-(1-hydroxy-1-methylethyl)-1-cyclohexene-1-carboxylic acid; (-)-oleuropeic acid
chembl4796626 ,
bdbm50553896
AKOS040762985

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Cocaine esterase	Homo sapiens (human)	IC50 (µMol)	1.9000	0.0058	2.4330	6.8000	AID1697438
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (3)

Process	via Protein(s)	Taxonomy
prostaglandin metabolic process	Cocaine esterase	Homo sapiens (human)
xenobiotic metabolic process	Cocaine esterase	Homo sapiens (human)
catabolic process	Cocaine esterase	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (3)

Process	via Protein(s)	Taxonomy
methylumbelliferyl-acetate deacetylase activity	Cocaine esterase	Homo sapiens (human)
carboxylesterase activity	Cocaine esterase	Homo sapiens (human)
carboxylic ester hydrolase activity	Cocaine esterase	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (3)

Process	via Protein(s)	Taxonomy
endoplasmic reticulum	Cocaine esterase	Homo sapiens (human)
endoplasmic reticulum lumen	Cocaine esterase	Homo sapiens (human)
intracellular membrane-bounded organelle	Cocaine esterase	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (1)

Assay ID	Title	Year	Journal	Article
AID1697438	Inhibition of CES2A1 in human liver microsomes using D-luciferin methyl ester as substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins by fluorescence assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Bioactivity-Guided Discovery of Human Carboxylesterase Inhibitors from the Roots of
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (11.11)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (33.33)	29.6817
2010's	3 (33.33)	24.3611
2020's	2 (22.22)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.58

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.58 (24.57)
Research Supply Index	2.30 (2.92)
Research Growth Index	4.88 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.58)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (11.11%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (88.89%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
phloroglucinol Phloroglucinol: A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.. phloroglucinol : A benzenetriol with hydroxy groups at position 1, 3 and 5.	2.05	1	benzenetriol; phenolic donor	algal metabolite
flavanone flavanone: RN given refers to cpd with unspecified isomeric designation; structure in first source. flavanone : The simplest member of the class of flavanones that consists of flavan bearing an oxo substituent at position 4.	2.07	1	flavanones
oleanolic acid [no description available]	2.25	1	hydroxy monocarboxylic acid; pentacyclic triterpenoid	plant metabolite
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	2.42	2	D-glucopyranose	epitope; mouse metabolite
ursolic acid [no description available]	2.25	1	hydroxy monocarboxylic acid; pentacyclic triterpenoid	geroprotector; plant metabolite
pinocembrin pinocembrin : A dihydroxyflavanone in which the two hydroxy groups are located at positions 5 and 7. A natural product found in Piper sarmentosum and Cryptocarya chartacea.	2.07	1	(2S)-flavan-4-one; dihydroxyflavanone	antineoplastic agent; antioxidant; metabolite; neuroprotective agent; vasodilator agent
lupeol [no description available]	2.25	1	pentacyclic triterpenoid; secondary alcohol	anti-inflammatory drug; plant metabolite
glycosides [no description available]	7.43	2
quercetin [no description available]	2.05	1	7-hydroxyflavonol; pentahydroxyflavone	antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger
cypellocarpin c cypellocarpin C: isolated from Eucalyptus cypellocarpa; structure in first source	2	1
23-hydroxybetulinic acid 23-hydroxybetulinic acid: structure in first source	2.25	1	triterpenoid	metabolite
ellagitannin ellagitannin: structure; precoxin A/ praecoxin A is a purified ellagitannin. ellagitannin : A form of hydrolysable tannin produced from ellagic acid. Ellagitannins are glucosides which are readily hydrolysed by water to regenerate ellagic acid when the plants are eaten.	2.05	1

Condition	Relationship Strength	Studies
Papilloma, Squamous Cell [description not available]	2	1
Cancer of Skin [description not available]	2	1
Papilloma A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)	2	1
Skin Neoplasms Tumors or cancer of the SKIN.	2	1

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