Gambling, Pathologic

Synonym
Pathological Gambling
Gambling, Pathologic
Gambling, Pathological

Excerpt	Reference
"Pathological gambling is a disabling disorder that affects at least 2 1/2 million Americans and their families."	( Cherkasky, S; DeCaria, CM; Grossman, R; Hollander, E; Mosovich, SA; Wong, CM, 1996)
"Pathological gambling is substantially more prevalent among cocaine-dependent outpatients than in the general population."	( Carriero, NJ; Gorelick, DA; Hall, GW; Montoya, ID; Preston, KL; Takushi, RY, 2000)
"Pathological gambling is classified as a disorder of impulse control, yet little research has evaluated behavioral indices of impulsivity in gamblers."	( Petry, NM, 2001)
"Pathological gambling is a disabling disorder associated with high rates of social and legal difficulties."	( Grant, JE; Kim, SW, 2001)
"Pathological gambling is a disabling and highly prevalent impulse-control disorder not otherwise specified (NOS)."	( Baldini Rossi, N; Hollander, E; Pallanti, S; Sood, E, 2002)
"Pathological gambling is frequently comorbid with bipolar spectrum disorders, substance abuse/dependence, and attention-deficit/hyperactivity disorder (ADHD), and comorbidity may influence treatment response in pathological gambling."	( Baker, B; Baldini-Rossi, N; Hollander, E; Pallanti, S; Sood, E, 2005)
"Pathological gambling is a rare potential complication related to treatment of Parkinson disease (PD)."	( Ahlskog, JE; Bower, JH; Dodd, ML; Geda, YE; Josephs, KA; Klos, KJ, 2005)
"Pathological gambling is an impulse -control disorder not otherwise specified (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) in which comorbidity is common, particularly with substance abuse, obsessive-compulsive disorder and mood disorders."	( Dell'Osso, B; Hollander, E, 2005)
"Pathological gambling is a disabling disorder experienced by approximately 1%-2% of adults and for which there are few empirically validated treatments."	( Cunningham-Williams, R; Grant, JE; Hollander, E; Kallio, A; Nurminen, T; Potenza, MN; Smits, G, 2006)
"Pathological gambling is a serious social issue, but the underlying psychological motivations are poorly understood."	( Chae, PK; Kim, YK; Lee, HP; Lee, HS, 2007)
"Pathological gambling is associated with bipolar disorder and dopamine dysfunction."	( Kaehler, L; Keck, PE; McElroy, SL; Nelson, EB; Welge, JA, 2008)
"Pathological gambling is a main focus of the review in that most biological studies of the formal impulse control disorders have examined this disorder."	( Potenza, MN; Williams, WA, 2008)
"Pathological gambling is an impulse control disorder reported in association with dopamine agonists used to treat Parkinson's disease."	( Houle, S; Lang, AE; Miyasaki, J; Pellecchia, G; Rusjan, P; Steeves, TD; Strafella, AP; Van Eimeren, T; Zurowski, M, 2009)
"Pathological gambling is a disruptive behaviour and an important public health concern that is classified as an impulse control disorder, and is also conceptualized as a prototype of 'behavioural addiction'."	( Allen, A; Bernardi, S; Hollander, E; Pallanti, S, 2010)
"Pathological gambling is a disabling disorder experienced by about 1% of adults."	( Grant, JE; Hollander, E; Kim, SW; Odlaug, BL; Potenza, MN, 2010)
"Pathological gambling is associated with compositional but not structural differences in social networks."	( Campbell, WK; Clifton, AD; Goodie, AS; Mackillop, J; Meisel, MK; Miller, JD, 2013)
"Pathological gambling is an addictive disorder characterized by a persistent and compulsive desire to engage in gambling activities."	( Barbalat, G; Domenech, P; Dreher, JC; Sescousse, G, 2013)
"The probability that pathological gambling is actually due to aripiprazole is "possible" in 7 cases out of 8, and "doubtful" in one."	( Allain-Veyrac, G; Gaboriau, L; Gérardin, M; Grall-Bronnec, M; Jolliet-Evin, P; Victorri-Vigneau, C, 2014)
"Pathological gambling is associated with elevated proportions of nicotine dependence, and tobacco smoking in pathological gamblers has been associated with increased problem-gambling severity."	( Chamberlain, SR; Donahue, CB; Grant, JE; Kim, SW; Odlaug, BL; Potenza, MN; Schreiber, LR, 2014)
"Pathological gambling is defined as inappropriate, persistent, and maladaptive gambling behaviour."	( Grötsch, P; Lang, U; Lange, C; Wiesbeck, GA, 2015)
"Pathological gambling is thought to result from a shift of balance between two competing neurobiological mechanisms: on the one hand the reward system involved in the regulation of the urge to get rewards and on the other hand the top-down control system."	( Fehr, T; Herrmann, M; Marco-Pallarés, J; Miedl, SF; Münte, TF; Wiswede, D; Ye, Z, 2015)
"Pathological gambling is a psychiatric disorder and the first recognized behavioral addiction, with similarities to substance use disorders but without the confounding effects of drug-related brain changes."	( Bowden-Jones, H; Brailsford, AD; Clark, L; Colasanti, A; Erritzoe, D; Galduróz, JC; Gunn, RN; Lingford-Hughes, AR; Mick, I; Myers, J; Nutt, DJ; Parkin, MC; Rabiner, EA; Ramos, AC; Searle, GE; Stokes, PR; Waldman, AD, 2016)
"Pathological gambling is a growing health problem in Romania, recognized in DSM V (2013) as a form of psychopathology included in the category of addictions."	( Ciobotaru, CM; Clinciu, AI, 2022)

Excerpt	Reference
"Although pathological gambling has been characterized as an impulse control disorder, it has also been associated with compulsivity."	( Cherkasky, S; DeCaria, CM; Grossman, R; Hollander, E; Mosovich, SA; Wong, CM, 1996)
"In the recent past, pathological gambling has been increasingly reported to be related with dopamine agonist application in patients with Parkinson's disease."	( Grips, E; Karachalios, G; Papadimitriou, G; Spengos, K; Tsivgoulis, G, 2006)
"Pathological gambling has received little attention from clinicians and researchers despite prevalence rates similar to or greater than those of schizophrenia and bipolar disorder."	( Grant, JE; Kim, SW, 2006)
"Pathological gambling has many similarities to pharmacological addiction."	( Franco, C; Frye, CA; Paris, JJ; Sodano, R; Wulfert, E, 2010)
"However, pathological gambling has been associated with dopamine agonist use."	( Grötsch, P; Lang, U; Lange, C; Wiesbeck, GA, 2015)
"Pathological gambling has been associated with dopamine transmission abnormalities, in particular dopamine D2-receptor deficiency, and reversal learning deficits."	( Cools, R; Geurts, DE; Hashemi, MM; Janssen, LK; Sescousse, G; ter Huurne, NP; Timmer, MH, 2015)
"Pathological gambling has been reported as a direct complication of Parkinson's disease and its pharmacological treatment based on dopamine agonists."	( Capuano, A; Rafaniello, C; Rossi, F; Scavone, C; Sportiello, L; Stelitano, B, 2020)

Excerpt	Reference
"Pathological gambling affects 1-3% of the adult population, and has high comorbidity."	( Berenguer, J; Berlin, HA; Buchsbaum, MS; Chaplin, W; Goodman, CR; Haznedar, MM; Hollander, E; LiCalzi, EM; Newmark, R; Pallanti, S, 2008)

Excerpt	Reference
"Patients with pathological gambling (lifetime or current) did not differ significantly from other patients in length of treatment or proportion of cocaine-positive urine samples."	( Carriero, NJ; Gorelick, DA; Hall, GW; Montoya, ID; Preston, KL; Takushi, RY, 2000)
"Patients with pathological gambling differ from other cocaine-dependent outpatients in some sociodemographic characteristics but not in short-term outcome of treatment for cocaine dependence."	( Carriero, NJ; Gorelick, DA; Hall, GW; Montoya, ID; Preston, KL; Takushi, RY, 2000)
"Citalopram appears to be an effective treatment for pathological gambling, and this benefit was independent of its antidepressant properties."	( Breen, RB; Posternak, MA; Zimmerman, M, 2002)
"The occurrence of a pathological gambling behavior in a 61-year-old patient with idiopathic Parkinson's disease treated with dopaminergic drugs is reported."	( Bagheri, H; Montastruc, JL; Schmitt, L, 2003)
"Forty pathological gambling patients with bipolar spectrum disorders entered a 10-week randomized, double-blind, placebo-controlled treatment study of sustained-release lithium carbonate."	( Allen, A; Baldini Rossi, N; Hollander, E; Pallanti, S; Sood, E, 2005)
"All 11 patients with PD and pathological gambling were taking therapeutic doses of a dopamine agonist; 3 of these patients were not treated with levodopa."	( Ahlskog, JE; Bower, JH; Dodd, ML; Geda, YE; Josephs, KA; Klos, KJ, 2005)
"A 30-year-old woman with severe pathological gambling and cyclothymia presented to our program with no previous history of pharmacologic or psychotherapeutic treatment."	( Dell'Osso, B; Hollander, E, 2005)
"We report 6 patients with pathological gambling during pharmacologic treatment for Parkinson disease (PD)."	( Imamura, A; Uitti, RJ; Wszolek, ZK, 2006)
"To describe the recurrent emergence of pathologic gambling (PG) during the sequential treatment of a patient with Juvenile Parkinson disease (PD) with different dopamine agonists."	( de Freitas, GR; Fontenelle, LF; Garcia, RF; Mendlowicz, MV; Nazar, BP; Ordacgi, L; Rosso, AL, 2007)
"Although pathological gambling (PG) is relatively common, pharmacotherapy research for PG is limited."	( Grant, JE; Kim, SW; Odlaug, BL, 2007)
"Pharmacological interventions for pathological gambling may be an adequate treatment alternative in pathological gambling."	( Arnestad, HM; Holsten, F; Iversen, E; Kvale, G; Laberg, JC; Molde, H; Pallesen, S; Skutle, A; Støylen, IJ, 2007)
"Although pathological gambling (PG) is relatively common, pharmacotherapy research for PG is limited."	( Chamberlain, SR; Grant, JE; Kim, SW; Odlaug, BL; Potenza, MN, 2010)
"We report a new case with pathological gambling plus hypersexuality and impotence in an old patient treated with a small dose (0."	( d'Orsi, G; Demaio, V; Specchio, LM, 2011)
"Problems with impulse control and pathological gambling are known as possible side effects of dopaminergic therapy in patients with Parkinson's disease."	( Connemann, BJ; Gahr, M; Schönfeldt-Lecuona, CJ, 2011)
"This study examined the relationship of pathological gambling to negative treatment outcomes for methadone maintenance patients aged 50 or older."	( Engel, RJ; Rosen, D, 2015)
"Common and unique findings in pathological gambling and cocaine dependence with respect to anticipatory reward and near-miss loss processing suggest shared and unique elements that might be targeted through behavioral or pharmacological interventions in the treatment of addictions."	( Malison, RT; Potenza, MN; Rogers, RD; Worhunsky, PD, 2014)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	39 (3.02)	23.3326
1990's	25 (1.94)	12.5806
2000's	293 (22.70)	18.1394
2010's	745 (57.71)	28.8240
2020's	189 (14.64)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	medium	7	1
5-hydroxytryptophan	low	1	0
acetaldehyde	low	1	0
carbamates	low	1	0
carbon monoxide	low	1	0
salicylic acid	low	1	0
bupropion	medium	7	4
3,4-dihydroxyphenylacetic acid	low	2	0
formaldehyde	low	1	0
dihydroxyphenylalanine	low	3	0
methylmercaptan	low	1	0
nickel	low	1	0
taurine	medium	3	1
uric acid	low	2	0
8-hydroxy-2-(di-n-propylamino)tetralin	low	1	0
ibotenic acid	low	1	0
vanilmandelic acid	low	1	0
1-(3-chlorophenyl)piperazine	medium	1	1
3,4-methylenedioxyamphetamine	low	1	0
n-methyl-3,4-methylenedioxyamphetamine	low	4	0
homovanillic acid	low	2	0
hydroxyindoleacetic acid	low	4	0
amantadine	medium	2	1
dan 2163	low	1	0
aspirin	medium	1	1
baclofen	low	4	0
benserazide	low	1	0
buspirone	low	1	0
caffeine	low	7	0
carbamazepine	medium	4	2
citalopram	medium	10	4
clomipramine	medium	4	1
clonidine	medium	2	1
amphetamine	medium	17	1
disulfiram	low	3	0
valproic acid	medium	3	1
fentanyl	low	2	0
fluphenazine	low	2	0
fluoxetine	medium	4	1
vanoxerine	low	1	0
guanfacine	low	1	0
haloperidol	medium	7	2
ketamine	low	3	0
ketanserin	low	1	0
letrozole	medium	1	1
mecamylamine	low	1	0
memantine	medium	2	1
mescaline	low	1	0
methadone	medium	16	1
methylphenidate	medium	3	2
mianserin	low	1	0
mirtazapine	low	1	0
modafinil	medium	5	2
muscimol	low	3	0
1-(3-trifluoromethylphenyl)piperazine	medium	1	1
nefazodone	medium	2	1
nitroglycerin	low	1	0
oxotremorine	low	1	0
piribedil	low	2	0
propranolol	low	1	0
risperidone	medium	4	1
ro 15-4513	low	2	0
ropinirole	low	13	0
saccharin	low	1	0
sulpiride	medium	3	2
sumatriptan	medium	1	1
xylazine	low	1	0
corticosterone	low	1	0
lysergic acid diethylamide	low	3	0
dextroamphetamine	medium	5	1
triiodothyronine	low	1	0
aspartic acid	medium	1	1
glutamine	low	1	0
sucrose	low	2	0
apomorphine	low	1	0
carbostyril	low	6	0
levodopa	medium	39	6
tyrosine	medium	1	1
methionine	medium	3	1
phenylalanine	medium	2	2
valine	medium	3	1
tryptophan	medium	10	5
phencyclidine	low	1	0
4-vinylpyridine	low	1	0
cyclohexanol	low	2	0
thiophenes	low	1	0
yohimbine	low	1	0
thiazoles	low	4	0
bicuculline	low	1	0
psilocybin	low	1	0
methoxyhydroxyphenylglycol	low	3	0
methamphetamine	medium	9	2
lithium carbonate	medium	6	1
acetylcysteine	medium	4	3
s,n,n'-tripropylthiocarbamate	medium	774	67
dronabinol	medium	6	1
flupenthixol	low	1	0
cyclazocine	low	1	0
n-methylaspartate	low	1	0
chromates	low	1	0
trolamine salicylate	low	2	0
selegiline	low	1	0
bromocriptine	medium	3	1
phenyl acetate	low	1	0
cetylpyridinium chloride anhydrous	medium	2	1
4-methoxyamphetamine	low	4	0
glutamic acid	medium	3	1
azides	low	2	0
propiconazole	medium	2	2
paroxetine	medium	8	5
pergolide	low	8	0
fenoxycarb	low	9	0
cabergoline	low	7	0
atomoxetine hydrochloride	low	4	0
mifepristone	low	1	0
fluorodopa f 18	low	3	0
eticlopride	low	1	0
finasteride	low	1	0
naxagolide	low	1	0
n 0437, (-)-isomer	low	1	0
aripiprazole	low	15	0
remifentanil	low	1	0
adenosine	low	1	0
carfentanil	low	2	0
venlafaxine hydrochloride	low	2	0
n-acetylaspartic acid	medium	1	1
triazoles	medium	4	2
fluorodeoxyglucose f18	medium	4	1
sertraline	medium	3	1
acamprosate	medium	2	1
1-benzylpiperazine	medium	1	1
s20098	medium	2	1
nicotine	medium	16	3
carbidopa, levodopa drug combination	low	2	0
sr141716	low	1	0
4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol	low	1	0
ecopipam	medium	1	1
pramipexole	medium	33	2
reboxetine	medium	1	1
ethylketocyclazocine	low	1	0
zm 241385	low	1	0
cp 101,606	low	1	0
lithium chloride	low	1	0
oxytocin	medium	1	1
cocaine	medium	18	2
eicosapentaenoic acid	low	1	0
buprenorphine	low	2	0
cotinine	low	3	0
urb 597	low	1	0
D-fructopyranose	medium	6	2
tamoxifen	low	1	0
lithium	medium	3	1
raclopride	medium	8	1
sch 23390	low	2	0
freedom	low	1	0
ketazocine	low	1	0
pd 168,077	low	3	0
tolcapone	medium	4	4
ro 60-0175	low	1	0
harmine	low	1	0
entacapone	low	1	0
humulene	medium	19	1
nalmefene	medium	8	4
naloxone	medium	5	3
topiramate	medium	6	2
morphine	low	2	0
mdl 100907	medium	3	1
fluvoxamine	medium	11	3
arsenic	low	1	0
naltrexone	medium	33	8
cysteine	low	1	0
heroin	medium	2	1
solanesol	low	1	0
benzoylamido-4'-aminostilbene-2,2'-disulfonate	low	1	0
radium	low	1	0
dizocilpine maleate	low	2	0
ergoline	low	7	0
flb 457	low	2	0
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane	low	3	0
n,n-dimethyl-2-(2-amino-4-methylphenylthio)benzylamine	low	2	0
alpha-synuclein	low	1	0
buprenorphine, naloxone drug combination	low	1	0
technetium tc 99m exametazime	medium	2	1
scopolamine hydrobromide	low	1	0
ants	low	1	0
cholecystokinin	low	1	0
beta-endorphin	medium	2	1
neuropeptide y	low	2	0
quetiapine fumarate	low	1	0
cardiovascular agents	low	1	0
piperidines	low	2	0
warfarin	medium	1	1
cpi203	low	1	0
rome	low	1	0
nitrophenols	medium	4	4
exudates	low	2	0
clozapine	medium	3	1
olanzapine	medium	5	3
eye	low	3	0
carbidopa	medium	6	1
ego	low	8	0
technetium tc 99m bicisate	low	1	0
metallothionein	low	1	0
leptin	low	1	0

Protein Targets (1,278)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	16	0	0	16
5-hydroxytryptamine receptor 3E	0	10	0	10
acetylcholinesterase	25	0	0	25
TDP1 protein	52	0	0	52
cytochrome P450 2D6	38	0	0	38
v-jun sarcoma virus 17 oncogene homolog (avian)	21	0	0	21
cytochrome P450 2D6 isoform 1	23	0	0	23
cellular tumor antigen p53 isoform a	7	0	0	7
cytochrome P450 2C19 precursor	19	0	0	19
cytochrome P450 2C9 precursor	16	0	0	16
thyroid hormone receptor beta isoform a	13	0	0	13
thyroid hormone receptor beta isoform 2	46	0	0	46
huntingtin isoform 2	7	0	0	7
peripheral myelin protein 22	28	0	0	28
cytochrome P450 3A4 isoform 1	24	0	0	24
muscarinic acetylcholine receptor M1	24	0	0	24
Gamma-aminobutyric acid receptor subunit pi	24	9	2	35
Polyunsaturated fatty acid lipoxygenase ALOX15B	11	0	0	11
ATP-binding cassette sub-family C member 3	0	40	0	40
Multidrug resistance-associated protein 4	0	41	0	41
5-hydroxytryptamine receptor 3B	0	10	0	10
Bile salt export pump	0	58	0	58
Beta-1 adrenergic receptor	0	9	1	10
5-hydroxytryptamine receptor 1A	0	28	14	43
5-hydroxytryptamine receptor 2C	0	37	7	44
D(2) dopamine receptor	0	62	14	84
5-hydroxytryptamine receptor 2A	0	40	8	49
Gamma-aminobutyric acid receptor subunit beta-1	24	9	2	35
Alpha-1B adrenergic receptor	0	37	7	44
Gamma-aminobutyric acid receptor subunit delta	24	9	2	35
Gamma-aminobutyric acid receptor subunit gamma-2	24	9	4	37
D	0	28	0	30
5-hydroxytryptamine receptor 1A	0	45	8	56
Gamma-aminobutyric acid receptor subunit alpha-5	24	9	2	35
Gamma-aminobutyric acid receptor subunit alpha-3	24	9	2	35
Gamma-aminobutyric acid receptor subunit gamma-1	24	9	2	35
Gamma-aminobutyric acid receptor subunit alpha-2	24	9	2	35
Alpha-1D adrenergic receptor	0	31	7	39
5-hydroxytryptamine receptor 2A	0	46	10	60
5-hydroxytryptamine receptor 2C	0	45	6	52
Gamma-aminobutyric acid receptor subunit alpha-4	24	9	2	35
Gamma-aminobutyric acid receptor subunit gamma-3	24	9	2	35
5-hydroxytryptamine receptor 1B	0	36	5	42
5-hydroxytryptamine receptor 1D	0	17	6	24
Gamma-aminobutyric acid receptor subunit alpha-6	24	9	2	35
5-hydroxytryptamine receptor 1F	0	16	5	22
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 2B	0	33	7	40
Sodium-dependent serotonin transporter	0	49	11	60
5-hydroxytryptamine receptor 7	0	15	5	20
5-hydroxytryptamine receptor 7	0	19	1	20
Alpha-1B adrenergic receptor	0	11	2	15
Glutamate receptor ionotropic, NMDA 1	0	19	2	26
5-hydroxytryptamine receptor 2B	0	43	5	49
Alpha-1A adrenergic receptor	0	39	8	47
5-hydroxytryptamine receptor 3A	0	13	0	13
Histamine H2 receptor	21	2	0	28
5-hydroxytryptamine receptor 6	0	34	1	37
Beta-2 adrenergic receptor	0	2	0	2
D(2) dopamine receptor	0	48	5	54
Gamma-aminobutyric acid receptor subunit alpha-1	24	10	4	38
Gamma-aminobutyric acid receptor subunit beta-3	24	9	2	35
Gamma-aminobutyric acid receptor subunit beta-2	24	9	4	37
Glutamate receptor ionotropic, NMDA 2A	0	19	2	26
Glutamate receptor ionotropic, NMDA 2B	0	20	2	27
Glutamate receptor ionotropic, NMDA 2C	0	19	2	27
Glutamate receptor ionotropic, NMDA 2D	0	18	2	25
5-hydroxytryptamine receptor 3D	0	10	0	10
Glutamate receptor ionotropic, NMDA 3B	0	18	2	25
5-hydroxytryptamine receptor 3C	0	10	0	10
GABA theta subunit	24	9	2	35
Canalicular multispecific organic anion transporter 1	0	39	0	39
Gamma-aminobutyric acid receptor subunit epsilon	24	9	2	35
Glutamate receptor ionotropic, NMDA 3A	0	18	2	25
aldehyde dehydrogenase 1 family, member A1	23	0	0	23
histone acetyltransferase KAT2A isoform 1	19	0	0	19
5-hydroxytryptamine receptor 1D	0	9	1	12
Caspase-3	0	1	1	2
Sodium-dependent dopamine transporter	0	38	6	44
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	23	0	0	23
Chain A, HADH2 protein	15	0	0	15
Chain B, HADH2 protein	15	0	0	15
Chain A, JmjC domain-containing histone demethylation protein 3A	12	0	0	12
Chain A, 2-oxoglutarate Oxygenase	17	0	0	17
Chain A, Protocatechuate 3,4-dioxygenase	0	0	1	1
Chain M, Protocatechuate 3,4-dioxygenase	0	0	1	1
Olfactory receptor class A-like protein 1	0	0	1	1
Luciferase	14	0	0	14
endonuclease IV	3	0	0	3
thioredoxin reductase	33	0	0	33
RGS12	1	0	0	1
phosphopantetheinyl transferase	26	0	0	26
NFKB1 protein, partial	13	0	0	13
GLS protein	40	0	0	40
Microtubule-associated protein tau	16	0	0	16
Thrombopoietin	9	0	0	9
alkaline phosphatase, intestinal	0	0	1	1
thioredoxin glutathione reductase	4	0	0	4
apical membrane antigen 1, AMA1	6	0	0	6
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11	0	0	11
thyroid stimulating hormone receptor	23	0	0	23
hypothetical protein, conserved	5	0	0	5
regulator of G-protein signaling 4	35	0	0	35
euchromatic histone-lysine N-methyltransferase 2	63	0	0	63
Bloom syndrome protein isoform 1	15	0	0	15
lysosomal alpha-glucosidase preproprotein	4	0	0	4
peripheral myelin protein 22 isoform 1	8	0	0	8
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	1	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	9	0	0	9
intestinal alkaline phosphatase precursor	0	1	0	1
chromobox protein homolog 1	32	0	0	32
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
DNA polymerase beta	3	0	0	3
flap endonuclease 1	13	0	0	13
DNA polymerase iota isoform a (long)	12	0	0	12
geminin	42	0	0	42
M-phase phosphoprotein 8	13	0	0	13
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
POsterior Segregation	0	0	3	3
lamin isoform A-delta10	34	0	0	34
Prolyl 4-hydroxylase subunit alpha-1	0	2	0	2
Sodium-dependent noradrenaline transporter	0	45	9	54
Zinc finger protein mex-5	0	0	2	2
ATP-dependent phosphofructokinase	33	0	0	33
Sodium-dependent dopamine transporter	0	24	4	28
5-hydroxytryptamine receptor 6	0	5	5	10
Sodium-dependent serotonin transporter	0	25	4	30
5-hydroxytryptamine receptor 5A	0	5	5	10
5-hydroxytryptamine receptor 5B	0	5	5	10
5-hydroxytryptamine receptor 3A	0	10	5	15
5-hydroxytryptamine receptor 4	0	5	5	10
5-hydroxytryptamine receptor 3B	0	10	5	15
estrogen-related nuclear receptor alpha	43	0	0	43
mu-type opioid receptor isoform MOR-1	0	0	3	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	9	0	0	9
5-hydroxytryptamine receptor 2A	0	0	3	3
Cytochrome P450 3A4	0	23	1	26
Neuronal acetylcholine receptor subunit alpha-4	1	4	4	10
Cytochrome P450 2C9	0	13	0	14
Neuronal acetylcholine receptor subunit beta-2	1	4	4	10
Translocator protein	0	2	1	3
D(3) dopamine receptor	0	24	1	25
Alpha-2B adrenergic receptor	0	21	4	26
D(2) dopamine receptor	0	11	0	11
Alpha-2C adrenergic receptor	0	21	4	26
Alpha-2A adrenergic receptor	0	22	4	27
Alpha-1D adrenergic receptor	0	31	2	35
5-hydroxytryptamine receptor 1B	0	8	3	11
Alpha-1A adrenergic receptor	0	16	3	21
5-hydroxytryptamine receptor 5A	0	7	0	7
5-hydroxytryptamine receptor 7	0	11	0	11
D	0	5	0	5
5-hydroxytryptamine receptor 2A	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	41	1	42
Lysosomal alpha-glucosidase	0	3	0	3
Transporter	0	24	1	26
hypoxia-inducible factor 1 alpha subunit	17	0	0	17
RAR-related orphan receptor gamma	37	0	0	37
SMAD family member 2	12	0	0	12
SMAD family member 3	12	0	0	12
GLI family zinc finger 3	39	0	0	39
AR protein	51	0	0	51
caspase 7, apoptosis-related cysteine protease	10	0	0	10
estrogen receptor 2 (ER beta)	22	0	0	22
nuclear receptor subfamily 1, group I, member 3	33	0	0	33
progesterone receptor	27	0	0	27
glucocorticoid receptor [Homo sapiens]	39	0	0	39
retinoic acid nuclear receptor alpha variant 1	36	0	0	36
retinoid X nuclear receptor alpha	27	0	0	27
farnesoid X nuclear receptor	21	0	0	21
pregnane X nuclear receptor	36	0	0	36
estrogen nuclear receptor alpha	55	0	0	55
peroxisome proliferator-activated receptor delta	21	0	0	21
peroxisome proliferator activated receptor gamma	23	0	0	23
vitamin D (1,25- dihydroxyvitamin D3) receptor	23	0	0	23
caspase-3	10	0	0	10
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	23	0	0	23
thyroid stimulating hormone receptor	20	0	0	20
activating transcription factor 6	11	0	0	11
thyrotropin-releasing hormone receptor	4	0	0	4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	18	0	0	18
Histone H2A.x	16	0	0	16
Caspase-7	5	0	0	5
caspase-3	5	0	0	5
heat shock protein beta-1	11	0	0	11
nuclear factor erythroid 2-related factor 2 isoform 1	33	0	0	33
Voltage-dependent calcium channel gamma-2 subunit	20	0	0	20
Cellular tumor antigen p53	33	0	0	33
Glutamate receptor 2	21	4	2	27
ATPase family AAA domain-containing protein 5	16	0	0	16
Ataxin-2	27	0	0	27
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
dopamine D1 receptor	8	0	0	8
15-lipoxygenase, partial	9	0	0	9
pregnane X receptor	7	0	0	7
USP1 protein, partial	23	0	0	23
arylsulfatase A	32	0	0	32
D(1A) dopamine receptor	31	0	0	31
survival motor neuron protein isoform d	13	0	0	13
Histone deacetylase 3	0	5	0	5
Solute carrier family 22 member 6	0	3	0	3
Histone deacetylase 4	0	5	0	5
Guanine nucleotide-binding protein G	3	0	0	3
Histone deacetylase 1	0	6	0	6
Histone deacetylase 7	0	5	0	5
Histone deacetylase 2	0	5	0	5
Polyamine deacetylase HDAC10	0	5	0	5
Histone deacetylase 11	0	5	0	5
Histone deacetylase 8	0	5	0	5
Histone deacetylase 6	0	6	0	6
Histone deacetylase 9	0	5	0	5
Histone deacetylase 5	0	5	0	5
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
signal transducer and activator of transcription 6, interleukin-4 induced	2	0	0	2
NPYLR7B	0	0	1	1
IDH1	13	0	0	13
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
mitogen-activated protein kinase 1	18	0	0	18
nuclear receptor ROR-gamma isoform 1	18	0	0	18
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Sodium/nucleoside cotransporter 2	0	2	0	2
Rap guanine nucleotide exchange factor 3	3	0	0	3
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	6	0	6
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	3	0	3
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	1	2
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	11	3	15
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Endoplasmin	0	1	1	2
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A1	0	8	2	15
Adenosine receptor A3	0	3	0	4
Adenosine receptor A2a	0	10	5	18
Adenosine receptor A2b	0	3	1	8
Adenosine receptor A2b	0	4	2	7
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	9	4	16
Adenosine receptor A2a	0	5	4	15
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	1	1	2
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	3
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
EWS/FLI fusion protein	25	0	0	25
putative alpha-glucosidase	1	0	0	1
Solute carrier family 22 member 2	0	5	0	7
Solute carrier family 22 member 1	0	14	0	18
Glutamate receptor ionotropic, NMDA 2D	0	7	0	7
Glutamate receptor ionotropic, NMDA 3B	0	7	0	7
Matrix protein 2	0	1	1	2
Matrix protein 2	0	1	2	3
Spike glycoprotein	25	2	3	30
Glutamate receptor ionotropic, NMDA 1	0	10	0	10
Glutamate receptor ionotropic, NMDA 2A	0	10	0	10
Glutamate receptor ionotropic, NMDA 2B	0	10	0	10
Glutamate receptor ionotropic, NMDA 2C	0	7	0	7
Solute carrier family 22 member 1	0	5	0	6
Glutamate receptor ionotropic, NMDA 3A	0	7	0	7
Multidrug and toxin extrusion protein 1	0	6	0	6
Solute carrier family 22 member 2	0	4	0	5
Solute carrier family 22 member 3	0	3	0	3
Phenylethanolamine N-methyltransferase	0	4	0	4
Cytochrome P450 2A6	0	5	1	6
Substance-P receptor	0	1	0	1
Cytochrome P450 2A5	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	10	1	11
Beta-2 adrenergic receptor	0	5	1	7
Sigma non-opioid intracellular receptor 1	0	13	2	15
Chain A, Putative fructose-1,6-bisphosphate aldolase	8	0	0	8
cytochrome P450 family 3 subfamily A polypeptide 4	35	0	0	35
aryl hydrocarbon receptor	17	0	0	17
vitamin D3 receptor isoform VDRA	18	0	0	18
potassium voltage-gated channel subfamily H member 2 isoform d	27	0	0	27
lethal factor (plasmid)	16	0	0	16
Integrin beta-3	5	1	1	7
Integrin alpha-IIb	5	1	1	7
Tryptophan 5-hydroxylase 1	0	4	0	4
D(1A) dopamine receptor	0	31	6	41
D(4) dopamine receptor	0	31	5	41
D(1B) dopamine receptor	0	13	1	17
D(1B) dopamine receptor	0	13	0	13
D(4) dopamine receptor	0	15	1	16
D(3) dopamine receptor	0	44	8	60
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
D	0	10	0	10
Fumarate hydratase	17	0	0	17
PPM1D protein	11	0	0	11
G	19	0	0	19
polyprotein	17	0	0	17
67.9K protein	7	0	0	7
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
transcriptional regulator ERG isoform 3	5	0	0	5
neuropeptide S receptor isoform A	7	0	0	7
5-hydroxytryptamine receptor 3A	0	2	1	3
Interferon beta	26	0	0	26
HLA class I histocompatibility antigen, B alpha chain	19	0	0	19
ATP-dependent translocase ABCB1	0	16	1	21
Alpha-2C adrenergic receptor	0	32	3	36
Muscarinic acetylcholine receptor M3	0	25	4	29
Histamine H1 receptor	0	5	0	5
Histamine H1 receptor	0	23	4	29
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	4	0	4
Inositol monophosphatase 1	12	0	0	12
Potassium voltage-gated channel subfamily H member 2	0	36	0	37
Multidrug and toxin extrusion protein 2	0	3	0	3
Inositol hexakisphosphate kinase 1	19	0	0	19
Histamine H3 receptor	0	6	0	6
cytochrome P450 2C9, partial	19	0	0	19
Chain A, Ferritin light chain	10	0	0	10
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
Carbonic anhydrase 1	0	12	0	21
Carbonic anhydrase 2	0	14	2	25
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Metabotropic glutamate receptor 1	0	2	2	5
Metabotropic glutamate receptor 2	0	2	3	6
Carbonic anhydrase-like protein, putative	0	0	0	7
Carbonic anhydrase 4	0	3	0	4
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	2	0	0	2
glucocerebrosidase	9	0	0	9
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
DNA polymerase kappa isoform 1	12	0	0	12
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Myeloperoxidase	0	3	0	3
Prostaglandin G/H synthase 1	0	3	0	3
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	6	0	6
Substance-P receptor	0	3	0	3
Prostaglandin G/H synthase 2	0	4	0	4
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	4	0	0	4
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	2	0	2
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
glp-1 receptor, partial	10	0	0	10
Carbonic anhydrase 4	0	5	0	10
Carbonic anhydrase	0	2	0	6
Carbonic anhydrase 15	0	4	0	8
ATAD5 protein, partial	19	0	0	19
Gamma-aminobutyric acid type B receptor subunit 2	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 2	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 1	0	2	0	2
serine/threonine-protein kinase mTOR isoform 1	15	0	0	15
Zinc finger protein mex-5	0	0	1	1
Genome polyprotein	0	1	0	1
Replicase polyprotein 1ab	0	5	3	8
D(1A) dopamine receptor	10	2	0	12
Hexokinase-2	0	1	0	1
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	0	7	0	7
Gamma-aminobutyric acid receptor subunit delta	0	7	0	7
Gamma-aminobutyric acid receptor subunit alpha-1	0	8	4	12
Gamma-aminobutyric acid receptor subunit beta-1	0	7	2	9
Gamma-aminobutyric acid receptor subunit gamma-2	0	8	2	10
Gamma-aminobutyric acid receptor subunit beta-3	0	8	2	10
Gamma-aminobutyric acid receptor subunit alpha-5	0	8	3	11
Gamma-aminobutyric acid receptor subunit alpha-3	0	8	2	10
Gamma-aminobutyric acid receptor subunit alpha-2	0	8	2	10
Gamma-aminobutyric acid receptor subunit beta-2	0	8	2	10
Gamma-aminobutyric acid receptor subunit alpha-4	0	8	2	10
Gamma-aminobutyric acid receptor subunit epsilon	0	7	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	0	8	2	10
Gamma-aminobutyric acid receptor subunit gamma-1	0	7	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	0	7	0	7
Gamma-aminobutyric acid receptor subunit theta	0	7	0	7
Genome polyprotein	0	1	1	2
5-hydroxytryptamine receptor 4	0	30	0	30
ATP-dependent translocase ABCB1	0	2	0	2
Alpha-2A adrenergic receptor	0	40	5	46
Androgen receptor	0	9	0	9
Alpha-2B adrenergic receptor	0	39	2	42
ATP-dependent translocase ABCB1	0	2	1	3
Alpha-synuclein	2	3	0	5
Kappa-type opioid receptor	0	13	1	16
Kappa-type opioid receptor	0	22	6	34
Acetylcholine receptor subunit alpha	0	3	2	5
Acetylcholine receptor subunit gamma	0	3	2	5
Integrin alpha-5	0	1	0	1
Acetylcholine receptor subunit beta	0	3	2	5
UDP-glucuronosyltransferase 2B7	0	3	0	6
Neuronal acetylcholine receptor subunit beta-2	0	4	1	7
UDP-glucuronosyltransferase 1-6	0	1	0	2
Cytochrome P450 2B6	0	3	1	6
UDP-glucuronosyltransferase 1A1	0	1	0	2
UDP-glucuronosyltransferase 1A4	0	1	0	5
Neuronal acetylcholine receptor subunit beta-4	0	4	1	7
Neuronal acetylcholine receptor subunit alpha-3	0	4	1	5
Cytochrome P450 2C19	0	8	0	9
UDP-glucuronosyltransferase 2B10	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	4	2	6
Neuronal acetylcholine receptor subunit alpha-4	0	4	1	7
Acetylcholine receptor subunit delta	0	3	2	5
Bile salt export pump	0	9	0	9
Beta-2 adrenergic receptor	0	7	0	8
Angiotensin-converting enzyme	0	1	0	1
Beta-1 adrenergic receptor	0	6	1	8
Beta-3 adrenergic receptor	0	5	0	5
Alpha-2A adrenergic receptor	0	2	0	2
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, glycogen phosphorylase, liver form	0	0	2	2
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, Chitinase	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	6	0	0	6
Potassium channel subfamily K member 2	0	3	2	5
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Cholinesterase	0	3	0	3
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	4	3	7
Amine oxidase [flavin-containing] A	0	9	0	9
Acetylcholinesterase	0	7	0	7
Amine oxidase [flavin-containing] B	0	8	1	9
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	1	0	2
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	1	0	2
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	3
Guanine deaminase	0	2	0	2
Chain A, Beta-lactamase	12	0	0	12
Vpr	2	0	0	2
Albumin	0	0	6	6
Major prion protein	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sodium channel protein type 3 subunit alpha	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	3	0	4
Cytochrome P450 2J2	0	8	0	9
Sodium channel protein type 9 subunit alpha	0	3	0	3
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	3	0	3
Chain A, serum paraoxonase	0	1	0	1
Carbonic anhydrase 12	0	5	0	10
Carbonic anhydrase 3	0	5	0	9
Neutrophil cytosol factor 1	0	1	0	1
Carbonic anhydrase 6	0	5	0	10
Carbonic anhydrase 5A, mitochondrial	0	5	1	11
Carbonic anhydrase 7	0	5	0	10
Carbonic anhydrase 9	0	6	1	13
Carbonic anhydrase 13	0	2	0	3
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
Carbonic anhydrase 14	0	4	0	9
Carbonic anhydrase 5B, mitochondrial	0	5	0	10
Delta-type opioid receptor	0	14	4	19
Mu-type opioid receptor	0	15	5	23
Kappa-type opioid receptor	0	8	4	13
Mu-type opioid receptor	0	25	10	40
Delta-type opioid receptor	0	18	6	29
Caspase-2	0	0	1	1
NPC intracellular cholesterol transporter 1 precursor	6	0	0	6
Sodium-dependent noradrenaline transporter	0	3	0	3
Aldo-keto reductase family 1 member B1	0	23	0	23
Angiotensin-converting enzyme	0	18	0	18
Aldo-keto reductase family 1 member B1	0	3	0	3
Aromatase	0	1	0	1
Sigma intracellular receptor 2	0	6	0	6
Sodium-dependent serotonin transporter	0	3	0	3
Sodium-dependent dopamine transporter	0	5	0	5
Nuclear receptor subfamily 3 group C member 3	0	17	0	17
Spike glycoprotein	0	2	3	5
Replicase polyprotein 1ab	0	2	3	5
atrial natriuretic peptide receptor 2 precursor	7	0	0	7
Transmembrane protease serine 2	0	2	3	5
Procathepsin L	0	2	3	5
Muscarinic acetylcholine receptor M2	0	23	4	27
Muscarinic acetylcholine receptor M4	0	23	3	26
Muscarinic acetylcholine receptor M5	0	22	2	24
Replicase polyprotein 1a	0	2	3	5
Replicase polyprotein 1ab	0	2	3	5
Cytochrome P450 2D6	0	15	1	19
Muscarinic acetylcholine receptor M1	0	27	5	32
Histamine H2 receptor	0	15	2	17
Trypanothione reductase	0	4	0	4
Histamine H1 receptor	0	6	0	6
Trypanothione reductase	0	1	0	1
Proteasome subunit alpha type-6	0	0	1	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Envelope glycoprotein	0	0	3	3
Angiotensin-converting enzyme 2	0	2	3	5
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Chain A, Cruzipain	6	0	0	6
Beta-1 adrenergic receptor	0	2	2	5
Alpha-1B adrenergic receptor	0	0	1	1
Membrane primary amine oxidase	0	1	0	1
Solute carrier family 22 member 3	0	3	0	3
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-2B adrenergic receptor	0	2	0	3
Delta-type opioid receptor	0	14	2	20
Mu-type opioid receptor	0	16	2	19
Alpha-2C adrenergic receptor	0	2	0	3
Alpha-2A adrenergic receptor	0	2	0	3
Nischarin	0	2	0	2
Nischarin	0	3	0	3
bromodomain adjacent to zinc finger domain 2B	8	0	0	8
Adenylate cyclase type 1	0	2	0	2
short transient receptor potential channel 6 isoform 1	0	0	1	1
transient receptor potential cation channel subfamily V member 1	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	5	1	6
Muscarinic acetylcholine receptor M1	0	12	1	13
Muscarinic acetylcholine receptor M3	0	10	1	11
Muscarinic acetylcholine receptor M4	0	11	1	12
Muscarinic acetylcholine receptor M5	0	11	1	12
Calmodulin-1	0	1	0	1
Muscarinic acetylcholine receptor M2	0	11	2	13
Endothelin receptor type B	0	2	0	2
Adenylate cyclase type 3	0	2	0	2
5-hydroxytryptamine receptor 3A	0	4	0	4
Endothelin receptor type B	0	2	0	2
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
5-hydroxytryptamine receptor 2C	0	3	0	3
5-hydroxytryptamine receptor 2A	0	3	0	3
Adenylate cyclase type 8	0	2	0	2
D(2) dopamine receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	2	0	2
D(2) dopamine receptor	0	5	0	5
Calmodulin	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	5	1	6
5-hydroxytryptamine receptor 2B	0	3	0	3
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
5-hydroxytryptamine receptor 4	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	5	1	6
Voltage-dependent L-type calcium channel subunit alpha-1C	0	6	1	7
Transporter	0	6	0	6
Cholecystokinin receptor type A	0	2	0	2
5-hydroxytryptamine receptor 1A	0	4	0	4
Adenylyl cyclase 7	0	2	0	2
Histamine H4 receptor	0	2	2	4
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Amyloid-beta precursor protein	1	1	0	2
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	2	0	2
Liver carboxylesterase 1	0	1	0	3
Lysosomal Pro-X carboxypeptidase	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Leukotriene B4 receptor 1	0	1	0	1
Leukotriene B4 receptor 2	0	1	0	1
GALC protein	7	0	0	7
nonstructural protein 1	7	0	0	7
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	1	2	2	6
C-8 sterol isomerase	0	3	0	3
Solute carrier organic anion transporter family member 1A1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	4	1	5
Cytochrome P450 1A2	0	5	0	5
Prolyl endopeptidase	0	1	0	1
Bromodomain-containing protein 4	0	1	0	1
Amine oxidase [flavin-containing] B	0	4	0	5
Amine oxidase [flavin-containing] B	0	4	0	4
Trace amine-associated receptor 1	0	0	2	2
Trace amine-associated receptor 1	0	0	2	2
Trace amine-associated receptor 1	0	0	3	3
Trace amine-associated receptor 1	0	0	2	2
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
runt-related transcription factor 1 isoform AML1b	3	0	0	3
core-binding factor subunit beta isoform 2	3	0	0	3
Glutamate receptor 1	1	4	2	7
Glutamate receptor 3	1	4	2	7
Glutamate receptor 4	1	4	2	7
Caspase-7	1	0	0	1
Smad3	7	0	0	7
pyruvate kinase	2	0	0	2
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
LacZ protein (plasmid)	0	0	1	1
beta-2 adrenergic receptor	3	0	0	3
type-1 angiotensin II receptor	0	1	0	1
perilipin-5	0	1	0	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
perilipin-1	0	1	0	1
histone deacetylase 9 isoform 3	2	0	0	2
polypyrimidine tract-binding protein 1 isoform a	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
apelin receptor	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	10	0	0	10
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
muscleblind-like protein 1 isoform 1	3	0	0	3
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase	0	1	0	1
pyruvate kinase PKM isoform b	1	0	0	1
Fatty-acid amide hydrolase 1	0	3	0	3
Transient receptor potential cation channel subfamily A member 1	0	0	3	4
Carbamate kinase	0	1	0	1
Retinal dehydrogenase 1	0	1	0	1
Aldehyde dehydrogenase, mitochondrial	0	1	0	1
Ornithine decarboxylase	1	0	0	1
Fructose-1,6-bisphosphatase 1	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	4	0	4
C-X-C chemokine receptor type 2	0	2	0	2
Mitogen-activated protein kinase 3	0	1	0	1
Protein-lysine 6-oxidase	0	1	0	1
Lysine-specific demethylase 5A	0	1	0	1
Caspase-1	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
C-C chemokine receptor type 4	0	2	0	2
C-C chemokine receptor type 5	0	2	0	2
Gasdermin-D	0	1	0	1
Lysyl oxidase homolog 3	0	1	0	1
TAR DNA-binding protein 43	7	0	0	7
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Lysyl oxidase homolog 4	0	1	0	1
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Monoglyceride lipase	0	2	0	2
Gasdermin-D	0	1	0	1
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
heat shock protein 90, putative	0	0	0	2
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
large T antigen	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
L-lactate dehydrogenase A chain	0	1	0	1
Fatty acid-binding protein, liver	0	2	0	2
Cannabinoid receptor 1	0	5	3	8
Cannabinoid receptor 1	0	4	3	12
Glycine receptor subunit alpha-1	0	0	2	2
Cannabinoid receptor 2	0	4	2	10
Cannabinoid receptor 1	0	3	1	4
Cannabinoid receptor 2	0	1	2	3
N-arachidonyl glycine receptor	0	1	1	2
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Lysophosphatidylserine lipase ABHD12	0	1	0	1
Monoacylglycerol lipase ABHD6	0	1	0	1
Cannabinoid receptor 2	0	2	0	2
G-protein coupled receptor 55	0	1	2	3
Chain A, Protein (peroxisome Proliferator Activated Receptor (ppar-delta))	0	1	0	1
Trypsin	0	1	0	1
Coagulation factor VII	0	2	0	2
Aromatase	0	3	0	3
Tissue factor	0	3	0	3
Retinoic acid receptor RXR-alpha	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	3	3
Oxoeicosanoid receptor 1	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	5
Catechol O-methyltransferase	0	2	0	2
Catechol O-methyltransferase	0	3	0	3
UDP-glucuronosyltransferase 2B15	0	0	0	2
Alpha-ketoglutarate-dependent dioxygenase FTO	0	2	0	2
Mu-type opioid receptor	0	6	2	13
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	2	0	2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase	0	1	0	1
ras-related protein Rab-9A	7	0	0	7
Cytochrome P450 2C8	0	4	0	4
Dipeptidyl peptidase 4	0	1	0	1
Acetylcholinesterase	0	1	0	1
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
NADPH oxidase 1	0	1	0	1
Snq2p	0	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	5	0	0	5
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Tyrosine-protein kinase Fyn	0	5	0	5
Beta-3 adrenergic receptor	0	7	1	8
Substance-K receptor	0	4	0	4
Melanocortin receptor 5	0	6	0	6
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
Disintegrin and metalloproteinase domain-containing protein 17	4	0	0	4
Cytochrome P450 1A2	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	4	0	4
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	4	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-2	0	0	2	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	2	2
ATP-citrate synthase	0	1	0	1
Glutamate receptor ionotropic, kainate 1	0	4	1	5
Metabotropic glutamate receptor 1	0	2	2	4
Metabotropic glutamate receptor 2	0	1	1	2
Metabotropic glutamate receptor 3	0	1	1	2
Metabotropic glutamate receptor 4	0	2	1	3
Metabotropic glutamate receptor 5	0	1	1	2
Metabotropic glutamate receptor 6	0	1	1	2
Metabotropic glutamate receptor 7	0	1	1	2
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	2	1	4
Glutamate receptor ionotropic, kainate 2	0	4	1	5
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	4	0	4
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	2	1	3
Fatty-acid amide hydrolase 1	0	3	0	3
Glutamate receptor ionotropic, kainate 4	0	4	0	4
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	2	2	5
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	4	0	4
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
POU domain, class 2, transcription factor 1	0	0	0	1
Cocaine esterase	0	2	0	2
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	2	0	2
Protease	0	3	0	3
Sodium channel protein type 2 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Chain A, Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
CDC-like kinase 1, isoform CRA_c	0	0	0	1
[Tau protein] kinase	0	1	0	1
dual specificity protein kinase CLK4	1	0	0	1
Dual specificity protein kinase CLK2	0	1	0	1
Dual specificity protein kinase CLK3	0	1	0	1
Dual specificity protein kinase CLK4	0	1	0	1
Acetylcholinesterase	0	5	0	5
Dual specificity tyrosine-phosphorylation-regulated kinase 3	0	1	0	1
Cyclin-T1	0	1	0	1
Serine/threonine-protein kinase D3	0	2	0	2
G2/mitotic-specific cyclin-B2	0	1	0	1
Protein kinase C gamma type	0	2	0	2
Protein kinase C beta type	0	2	0	2
Tyrosine-protein kinase Lck	0	3	0	3
Cyclin-dependent kinase 1	0	1	0	1
Beta-2 adrenergic receptor	0	5	1	6
Tyrosine-protein kinase Lyn	0	1	0	1
Serine/threonine-protein kinase pim-1	0	1	0	1
G2/mitotic-specific cyclin-B1	0	1	0	1
Protein kinase C alpha type	0	2	0	2
Cyclin-A2	0	1	0	1
Dual specificity protein kinase CLK1	0	1	0	1
Protein kinase C eta type	0	2	0	2
Cyclin-dependent kinase 2	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Neuromedin-B receptor	0	1	0	1
Protein kinase C iota type	0	2	0	2
Casein kinase I isoform delta	0	1	0	1
Casein kinase I isoform epsilon	0	1	0	1
Dual specificity protein kinase CLK1	0	1	0	1
Glycogen synthase kinase-3 alpha	0	1	0	1
Glycogen synthase kinase-3 beta	0	2	1	3
Cyclin-dependent kinase 7	0	1	0	1
Cyclin-dependent kinase 9	0	1	0	1
Cyclin-H	0	1	0	1
Mitogen-activated protein kinase 1	0	1	0	1
Cyclin-A1	0	1	0	1
Cholinesterase	0	3	0	3
Cyclin-dependent-like kinase 5	0	1	0	1
Protein kinase C epsilon type	0	2	0	2
Protein kinase C theta type	0	2	0	2
Protein kinase C zeta type	0	2	0	2
Protein kinase C delta type	0	2	0	2
Aldehyde oxidase	0	1	0	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	2	0	2
Cyclin-dependent kinase 5 activator 1	0	1	0	1
Serine/threonine-protein kinase D1	0	2	0	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
Serine/threonine-protein kinase pim-3	0	1	0	1
Serine/threonine-protein kinase haspin	0	1	0	1
G2/mitotic-specific cyclin-B3	0	1	0	1
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	1	0	1
Dual specificity tyrosine-phosphorylation-regulated kinase 4	0	1	0	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	2	0	2
ClpP	2	0	0	2
Solute carrier family 22 member 8	0	0	0	1
alpha-galactosidase	1	0	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
Synaptic vesicular amine transporter	0	2	0	2
Estrogen receptor	1	5	2	9
Steryl-sulfatase	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Amine oxidase [flavin-containing] A	0	3	0	4
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
Polyphenol oxidase 2	0	1	0	4
Plasma kallikrein	0	0	0	4
Tyrosinase	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Carbonic anhydrase	0	3	0	7
Large neutral amino acids transporter small subunit 1	0	6	0	7
SLC16A10 protein	0	0	0	4
Carbonic anhydrase	0	2	0	6
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	3	0	7
Carbonic anhydrase	0	2	0	6
Monocarboxylate transporter 10	0	0	0	4
Carbonic anhydrase 13	0	2	0	6
phosphoglycerate kinase	1	0	0	1
inositol monophosphatase 1	1	0	0	1
Cholecystokinin receptor type A	1	0	0	1
Gastrin/cholecystokinin type B receptor	1	0	0	1
5-hydroxytryptamine receptor 1E	0	3	0	3
Sodium-dependent dopamine transporter	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Cysteinyl leukotriene receptor 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	3	3	7
Neuronal acetylcholine receptor subunit alpha-2	0	2	3	6
Neuronal acetylcholine receptor subunit beta-3	0	2	3	6
Neuronal acetylcholine receptor subunit beta-4	0	3	3	7
Neuronal acetylcholine receptor subunit alpha-5	0	2	3	6
Neuronal acetylcholine receptor subunit alpha-6	0	3	3	7
Neuronal acetylcholine receptor subunit alpha-9	0	2	3	6
Acetylcholine receptor subunit epsilon	0	0	2	2
Neuronal acetylcholine receptor subunit alpha-7	0	5	3	9
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-10	0	2	3	6
Mas-related G-protein coupled receptor member X2	0	0	2	2
Aldehyde oxidase 1	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	1	0	2
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Endothelin-1 receptor	0	2	1	3
Type-2 angiotensin II receptor	0	3	0	3
Angiotensin-converting enzyme	0	2	0	2
5-hydroxytryptamine receptor 3B	0	2	0	2
G-protein coupled receptor	0	1	0	1
Chain A, PROGESTERONE RECEPTOR	0	1	0	1
Glucocorticoid receptor	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Glucocorticoid receptor	1	2	2	7
Progesterone receptor	0	3	1	6
Tegument protein VP16	0	0	1	1
Glucocorticoid receptor	0	1	1	3
Glucocorticoid receptor	0	1	0	1
Glycine receptor subunit alpha-1	0	2	0	2
Androgen receptor	1	3	1	5
Thyroid hormone receptor alpha	0	3	2	5
Thyroid hormone receptor beta	0	3	2	5
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Mitogen-activated protein kinase 14	0	1	0	1
Progesterone receptor	0	0	1	1
Estrogen receptor beta	1	4	2	7
Glucocorticoid receptor	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Histidine decarboxylase	0	0	3	3
Proteinase-activated receptor 1	0	1	1	2
Kappa-type opioid receptor	0	5	2	10
UDP-glucuronosyltransferase 1A3	0	0	0	1
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
D-amino-acid oxidase	0	1	0	1
5-hydroxytryptamine receptor 1B	0	2	0	2
Rap guanine nucleotide exchange factor 4	1	0	0	1
kappa-type opioid receptor isoform 1	0	1	0	1
Beta-galactosidase	0	0	1	1
UDP-glucuronosyltransferase 1A8	0	0	0	2
Nociceptin receptor	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
Neuropeptide Y receptor type 1	0	2	0	2
Neuropeptide Y receptor type 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Muscarinic acetylcholine receptor M4	0	1	1	3
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
polyadenylate-binding protein 1	0	1	0	1
bcl-2-related protein A1	0	1	0	1
MCOLN3 protein	0	0	1	1
transient receptor potential cation channel, subfamily N, member 1	0	0	1	1
Muscarinic acetylcholine receptor M1	0	0	2	3
Muscarinic acetylcholine receptor DM1	0	1	0	1
Mineralocorticoid receptor	0	0	1	1
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	2	2	4
Vasopressin V1a receptor	0	1	0	1
Vasopressin V1a receptor	0	3	2	5
Vasopressin V1b receptor	0	1	1	2
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	1	0	1
Oxytocin receptor	0	0	1	1
Vasopressin V2 receptor	0	1	0	1
Quinolone resistance protein NorA	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	1	2
Substance-P receptor	0	3	0	3
Rhodopsin kinase GRK1	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
P2X purinoceptor 4	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
Beta-adrenergic receptor kinase 1	0	0	0	1
Chain A, Immunoglobulin	0	0	1	1
Chain B, Immunoglobulin	0	0	1	1
Cholinesterase	0	1	0	1
Muscarinic acetylcholine receptor M5	0	0	1	2
Muscarinic acetylcholine receptor M3	0	0	1	2
Muscarinic acetylcholine receptor M2	0	0	1	2
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	2	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Phospholipase A-2-activating protein	0	2	0	2
Albumin	0	1	2	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Coagulation factor X	0	1	0	1
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	3	0	3
Taste receptor type 2 member 31	0	0	1	1
Beta-carbonic anhydrase 1	0	3	0	3
Carbonic anhydrase 2	0	3	0	3
Carbonic anhydrase, alpha family	0	3	0	3
Carbonic anhydrase	0	3	0	3
Delta carbonic anhydrase	0	3	0	3
RmtA	0	1	0	1
Protein arginine N-methyltransferase 1	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	1	0	2
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	1	1	2
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	1	0	2
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
Solute carrier family 22 member 8	0	2	0	2
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 3	0	1	0	1
Adenylate cyclase type 9	0	1	0	1
D(1) dopamine receptor	0	1	0	1
Adenylate cyclase type 8	0	1	0	1
Adenylate cyclase type 7	0	1	0	1
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
Cytochrome P450 2B1	0	1	0	1
Amine oxidase [flavin-containing] A	0	2	0	2
Type-1 angiotensin II receptor	0	1	0	1
C-X-C chemokine receptor type 3	0	2	0	2
Amine oxidase [flavin-containing] A	0	0	0	1
Amine oxidase [flavin-containing] B	0	0	0	1
Transcriptional activator protein LuxR	0	2	0	2
Orexin receptor type 1	0	0	0	1
Cathepsin B	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
G-protein coupled bile acid receptor 1	0	1	0	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	2	0	2
D(2) dopamine receptor	0	1	0	1
Carboxypeptidase M	0	1	0	1
5-hydroxytryptamine receptor 1F	0	2	1	3
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
Chain A, CES1 protein	0	1	0	1
DNA polymerase III, partial	1	0	0	1
interferon gamma precursor	0	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
streptokinase A precursor	0	0	1	1
Lysosomal acid glucosylceramidase	0	0	1	1
Protein kinase C alpha type	0	1	0	1
Estrogen receptor	0	0	1	2
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Steroid hormone receptor ERR1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
B2 bradykinin receptor	0	2	0	2
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
Estrogen receptor beta	0	0	1	2
Protein kinase C eta type	0	1	0	1
Emopamil-binding protein-like	0	1	0	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
Transthyretin	0	1	1	3
Genome polyprotein	0	1	1	2
Krueppel-like factor 10	0	1	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	0	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	1	0	2
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Proliferating cell nuclear antigen	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Coagulation factor XIII A chain	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Fatty-acid amide hydrolase 2	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Chain A, Arginase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Small conductance calcium-activated potassium channel protein 2	0	1	0	1
Small conductance calcium-activated potassium channel protein 3	0	1	0	1
Small conductance calcium-activated potassium channel protein 1	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
DNA topoisomerase 1	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
M-phase inducer phosphatase 1	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Chain A, Human Adenosine A2A receptor/T4 lysozyme chimera	0	0	1	1
Chain A, Adenosine receptor A2a	0	0	1	1
Chain A, Adenosine receptor A2a	0	0	1	1
Hexokinase-4	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(3)

Research Excerpts

Overview

Context

Actions

Treatment

Research

Studies (1,291)

Protein Targets (1,278)

Gambling, Pathologic

Synonyms(3)

Research Excerpts

Overview

Context

Actions

Treatment

Research

Studies (1,291)

Drugs Studied (228)

Protein Targets (1,278)