Sinus Tachycardia

Simple rapid heartbeats caused by rapid discharge of impulses from the SINOATRIAL NODE, usually between 100 and 180 beats/min in adults. It is characterized by a gradual onset and termination. Sinus tachycardia is common in infants, young children, and adults during strenuous physical activities.

Synonym
Tachycardia, Sinus
Sinus Tachycardia

Excerpt	Reference
"Sinus tachycardia is a common complication of beta-adrenergic agonist therapy."	( Benjamin, E; Berger, SR; Iberti, TJ; Kaplan, JA; Paluch, TA; Plawker, M, 1987)
"Inappropriate sinus tachycardia is a disease which is relatively rarely found and sometimes difficult to treat."	( Hennersdorf, M; Schulze, V; Steiner, S; Strauer, BE, 2008)
"Inappropriate sinus tachycardia is most often treated with beta-blockers; in resistant cases, nonpharmacologic treatment has been attempted."	( Rakovec, P, 2009)
"Sinus tachycardia is commonly encountered in clinical practice and when persistent, can result in significant symptoms and impaired quality of life, warranting further evaluation."	( Gopinathannair, R; Hottigoudar, RU, 2013)
"Inappropriate sinus tachycardia is characterized by an unexplained increase of the resting sinus rate (> 100 bpm) with excess increase in response to moderate activity (mean heart rate > 90 bpm/24 h)."	( Sossalla, S; Vollmann, D, 2015)
"Inappropriate sinus tachycardia is a challenging problem to manage."	( Olshansky, B; Sullivan, RM, 2016)
"Sinus tachycardia is a common adverse event associated with clozapine treatment."	( Docherty, MJ; Lally, J; MacCabe, JH, 2016)

Excerpt	Reference
"Inappropriate sinus tachycardia is a disease which is relatively rarely found and sometimes difficult to treat."	( Hennersdorf, M; Schulze, V; Steiner, S; Strauer, BE, 2008)
"The patient suffered from inappropriate sinus tachycardia that had been resistant to treatment with traditional rate-slowing medications."	( Hamid, S; Khan, S; Rinaldi, C, 2009)
"Inappropriate sinus tachycardia is most often treated with beta-blockers; in resistant cases, nonpharmacologic treatment has been attempted."	( Rakovec, P, 2009)
"Initial electrocardiograms revealed sinus tachycardia at a rate of 180 beats per minute, a prolonged QRS of 130 milliseconds (from a baseline of 65 milliseconds), and a positive terminal R wave in aVR, which later resolved after sodium bicarbonate treatment."	( Cole, JB; Gross, EA; Smith, SW; Stellpflug, SJ, 2011)
"Inappropriate sinus tachycardia (IST) often causes palpitations, dyspnea, and exercise intolerance, that are generally treated with beta blockers and non-dihydropyridine calcium-channel antagonists."	( Annamaria, M; Calo, L; Cappato, R; De Ambroggi, G; de Ruvo, E; Foresti, S; Lupo, PP; Sciarra, L, 2016)
"Inappropriate sinus tachycardia (IST) is debilitating despite available treatment."	( Mathew, ST; Po, SS; Thadani, U, 2018)
"Inappropriate sinus tachycardia (IST) remains a clinical challenge because patients often are highly symptomatic and not responsive to medical therapy."	( Ackerman, MJ; Asirvatham, SJ; Brady, PA; Cha, YM; Friedman, PA; Han, J; Kapa, SC; Lee, HC; Li, X; McLeod, CJ; Mulpuru, SK; Munger, TM; Noseworthy, PA; Rho, RH; Shen, WK; Tian, Y; Wu, G; Yang, M; Zhou, S, 2019)
"Effective therapy for inappropriate sinus tachycardia (IST) remains challenging with high rates of treatment failure and symptom recurrence."	( Asirvatham, SJ; Shabtaie, SA; Witt, CM, 2021)
"Inappropriate sinus tachycardia in denervated transplanted hearts is a good indication for ivabradine administration as beta-blockers have a limited efficacy."	( Inuzuka, R; Ogawa, Y; Urata, S, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	25 (9.09)	23.3326
1990's	42 (15.27)	12.5806
2000's	71 (25.82)	18.1394
2010's	109 (39.64)	28.8240
2020's	28 (10.18)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	1	0
bupropion	low	4	0
lactic acid	low	1	0
glycine	low	1	0
iodine	low	1	0
methanol	low	1	0
nitrous oxide	low	2	0
1-propanol	low	1	0
thiamine	low	1	0
urea	medium	4	1
1-anilino-8-naphthalenesulfonate	low	1	0
2,4-dinitrophenol	low	1	0
albuterol	low	4	0
theophylline	low	4	0
amiodarone	low	3	0
amitriptyline	low	4	0
aspirin	low	2	0
astemizole	low	1	0
atenolol	low	2	0
azathioprine	low	2	0
baclofen	low	2	0
bisoprolol	medium	3	2
bupivacaine	low	1	0
caffeine	low	1	0
verapamil	low	1	0
candesartan cilexetil	low	1	0
carbamazepine	low	1	0
carmustine	low	1	0
chlordiazepoxide	low	1	0
chlorpromazine	low	1	0
cilostamide	low	1	0
clenbuterol	low	4	0
clidinium	low	1	0
clomipramine	low	1	0
clonidine	low	3	0
cyclobenzaprine	low	1	0
desipramine	low	1	0
diazepam	low	1	0
diphenhydramine	low	6	0
disulfiram	low	1	0
valproic acid	low	1	0
flecainide	low	3	0
fluorouracil	low	2	0
fluoxetine	low	2	0
foscarnet	low	1	0
furosemide	low	1	0
gabapentin	low	1	0
guanethidine	low	1	0
haloperidol	low	3	0
hexamethonium	low	1	0
ibuprofen	low	1	0
lidocaine	low	3	0
ifosfamide	low	1	0
indomethacin	low	1	0
isoflurane	low	1	0
isoproterenol	low	11	0
labetalol	low	1	0
manidipine	low	1	0
meperidine	low	1	0
methylphenidate	low	1	0
metoprolol	medium	11	1
midazolam	low	3	0
milrinone	medium	1	1
apnea	low	1	0
naftopidil	low	1	0
nefazodone	low	1	0
neostigmine	low	1	0
nifedipine	low	1	0
nitroglycerin	low	2	0
orphenadrine	low	1	0
oxybutynin	low	1	0
periciazine	low	1	0
phenobarbital	low	2	0
piracetam	low	1	0
potassium chloride	low	1	0
prazosin	low	1	0
procaine	medium	1	1
promethazine	low	1	0
propofol	medium	2	1
propranolol	low	8	0
risperidone	low	1	0
rolipram	low	1	0
ropinirole	low	1	0
sevoflurane	low	1	0
sotalol	low	2	0
sulpiride	low	1	0
terbutaline	low	1	0
terfenadine	low	1	0
zaleplon	low	1	0
zonisamide	low	1	0
prednisolone	low	1	0
reserpine	low	1	0
sorbitol	low	1	0
thyroxine	low	2	0
carbachol	medium	1	1
penicillin g	low	2	0
triiodothyronine	low	1	0
serine	low	1	0
physostigmine	low	2	0
carbostyril	low	2	0
oxacillin	low	1	0
arginine	low	1	0
cyclizine	low	1	0
methylprednisolone	low	1	0
cyclohexanol	low	2	0
framycetin	low	1	0
yohimbine	low	2	0
isoxazoles	low	1	0
calcium gluconate	low	1	0
aminophylline	low	1	0
methamphetamine	low	2	0
hydrofluoric acid	low	2	0
dronabinol	medium	1	1
technetium	low	1	0
aluminum phosphide	low	1	0
carbimazole	low	1	0
tramadol	low	1	0
alinidine	low	2	0
dobutamine	low	2	0
diltiazem	low	1	0
vecuronium bromide	low	1	0
paroxetine	low	1	0
atracurium	low	1	0
fomesafen	low	3	0
haloperidol decanoate	low	2	0
atomoxetine hydrochloride	low	1	0
esmolol	medium	5	2
aripiprazole	low	2	0
adenosine	medium	7	1
cisatracurium	low	1	0
venlafaxine hydrochloride	low	3	0
cephalosporin c	low	1	0
zatebradine	low	1	0
triazoles	low	1	0
sertraline	low	1	0
falipamil	medium	3	1
rivastigmine	low	1	0
ecgonine methyl ester	low	1	0
1-hexadecyl-2-acetyl-glycero-3-phosphocholine	low	1	0
landiolol	medium	4	1
zd 7288	low	2	0
ivabradine	medium	67	9
angiotensin ii	low	1	0
atropine	medium	5	2
lacosamide	low	1	0
dihydropyridines	low	1	0
glycogen	low	1	0
inositol 3-phosphate	low	1	0
rocuronium	low	1	0
ryanodine	low	1	0
tacrolimus	low	1	0
cocaine	low	3	0
mycophenolic acid	low	1	0
benzoylecgonine	low	1	0
sodium bicarbonate	low	4	0
cocaethylene	low	1	0
physostigmine salicylate	low	1	0
methimazole	low	5	0
digoxin	medium	2	1
thiopental	low	1	0
sphingosine	low	1	0
bilirubin	low	1	0
cefzil	low	1	0
sphingosine 1-phosphate	low	1	0
levetiracetam	low	1	0
oxycodone	medium	1	1
thallium	low	1	0
enalapril	low	1	0
heroin	low	1	0
ici 118551	low	1	0
taxane	medium	1	1
paliperidone palmitate	low	1	0
rivaroxaban	low	2	0
cgp 20712a	low	1	0
1-phenyl-2-(1-pyrrolidinyl)-1-pentanone	low	1	0
scopolamine hydrobromide	low	1	0
pituitrin	medium	1	1
mesna	low	1	0
ro13-9904	low	3	0
quetiapine fumarate	low	1	0
cardiovascular agents	medium	13	2
natriuretic peptide, brain	low	3	0
warfarin	low	2	0
vitamin b 12	low	1	0
silybin	low	1	0
technetium tc-99m tetrofosmin	low	1	0
nedaplatin	low	1	0
clozapine	low	4	0
dacarbazine	low	1	0

Protein Targets (1,464)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	10	0	0	10
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	4	0	0	4
thioredoxin reductase	43	0	0	43
USP1 protein, partial	36	0	0	36
TDP1 protein	63	0	0	63
vitamin D3 receptor isoform VDRA	14	0	0	14
importin subunit beta-1 isoform 1	4	0	0	4
flap endonuclease 1	14	0	0	14
serine/threonine-protein kinase PLK1	4	0	0	4
snurportin-1	4	0	0	4
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	7	0	0	7
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
DNA polymerase eta isoform 1	5	0	0	5
DNA polymerase iota isoform a (long)	17	0	0	17
urokinase-type plasminogen activator precursor	8	0	0	8
plasminogen precursor	8	0	0	8
urokinase plasminogen activator surface receptor precursor	8	0	0	8
geminin	57	0	0	57
DNA polymerase kappa isoform 1	17	0	0	17
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	1	0	1
Transthyretin	0	1	1	4
Fatty acid-binding protein, intestinal	0	2	1	3
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	2	2	4
Cyclin-dependent kinase 2	0	1	1	2
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	5	0	0	5
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	22	0	0	22
Chain A, Cruzipain	9	0	0	9
regulator of G-protein signaling 4	30	0	0	30
Platelet-activating factor receptor	0	4	0	5
Inositol monophosphatase 1	14	0	0	14
Sodium-dependent noradrenaline transporter	0	53	7	60
Sodium-dependent serotonin transporter	0	47	7	54
Sodium-dependent dopamine transporter	0	44	4	48
acetylcholinesterase	26	0	0	26
pregnane X receptor	5	0	0	5
RAR-related orphan receptor gamma	46	0	0	46
GLI family zinc finger 3	45	0	0	45
AR protein	64	0	0	64
aldehyde dehydrogenase 1 family, member A1	26	0	0	26
thyroid stimulating hormone receptor	29	0	0	29
estrogen receptor 2 (ER beta)	29	0	0	29
nuclear receptor subfamily 1, group I, member 3	35	0	0	35
glucocorticoid receptor [Homo sapiens]	50	0	0	50
retinoic acid nuclear receptor alpha variant 1	41	0	0	41
retinoid X nuclear receptor alpha	33	0	0	33
estrogen-related nuclear receptor alpha	57	0	0	57
estrogen nuclear receptor alpha	69	0	0	69
67.9K protein	15	0	0	15
peroxisome proliferator-activated receptor delta	25	0	0	25
peroxisome proliferator activated receptor gamma	36	0	0	36
vitamin D (1,25- dihydroxyvitamin D3) receptor	24	0	0	24
aryl hydrocarbon receptor	23	0	0	23
cellular tumor antigen p53 isoform a	14	0	0	14
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	12	0	0	12
thyroid hormone receptor beta isoform a	14	0	0	14
nuclear factor erythroid 2-related factor 2 isoform 2	13	0	0	13
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
thyroid hormone receptor beta isoform 2	47	0	0	47
histone deacetylase 9 isoform 3	6	0	0	6
mitogen-activated protein kinase 1	21	0	0	21
nuclear factor erythroid 2-related factor 2 isoform 1	42	0	0	42
nuclear receptor ROR-gamma isoform 1	26	0	0	26
survival motor neuron protein isoform d	16	0	0	16
histone acetyltransferase KAT2A isoform 1	23	0	0	23
Voltage-dependent calcium channel gamma-2 subunit	23	0	0	23
Cellular tumor antigen p53	47	0	0	47
Integrin beta-3	9	1	0	10
Integrin alpha-IIb	9	1	0	10
Glutamate receptor 2	23	1	1	25
Nuclear receptor ROR-gamma	10	1	1	12
TAR DNA-binding protein 43	9	0	0	9
ATPase family AAA domain-containing protein 5	21	0	0	21
Ataxin-2	39	0	0	39
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
NPYLR7B	0	0	4	4
arylsulfatase A	31	0	0	31
IDH1	26	0	0	26
Histone H2A.x	21	0	0	21
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
peripheral myelin protein 22	37	0	0	37
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Sodium/nucleoside cotransporter 2	0	2	0	2
Rap guanine nucleotide exchange factor 3	4	0	0	4
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	9	0	9
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	4	0	4
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	1	2
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	13	3	17
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	3	0	3
Endoplasmin	0	1	1	2
Inosine-5'-monophosphate dehydrogenase 1	0	3	0	3
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A1	0	11	1	15
Adenosine receptor A3	0	3	0	3
Adenosine receptor A2a	0	7	6	16
Adenosine receptor A2b	0	2	1	6
Adenosine receptor A2b	0	5	2	9
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	9	4	18
Adenosine receptor A2a	0	9	2	16
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	3	1	4
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	3
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
glp-1 receptor, partial	19	0	0	19
GLS protein	34	0	0	34
euchromatic histone-lysine N-methyltransferase 2	62	0	0	62
thyroid stimulating hormone receptor	25	0	0	25
ATP-binding cassette sub-family C member 3	0	62	0	62
Multidrug resistance-associated protein 4	0	62	0	62
Bile salt export pump	0	91	0	91
Beta-2 adrenergic receptor	0	23	15	39
Beta-1 adrenergic receptor	0	24	12	36
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Beta-3 adrenergic receptor	0	10	10	20
Delta-type opioid receptor	0	6	2	8
10 kDa heat shock protein, mitochondrial	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
Beta-2 adrenergic receptor	0	1	5	12
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Beta-2 adrenergic receptor	0	3	9	14
Canalicular multispecific organic anion transporter 1	0	61	0	61
ATP-dependent phosphofructokinase	30	0	0	30
potassium voltage-gated channel subfamily H member 2 isoform d	29	0	0	29
Microtubule-associated protein tau	23	0	0	23
lamin isoform A-delta10	55	0	0	55
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	16	0	0	16
phosphopantetheinyl transferase	22	0	0	22
hypoxia-inducible factor 1 alpha subunit	18	0	0	18
SMAD family member 2	13	0	0	13
ATAD5 protein, partial	29	0	0	29
Fumarate hydratase	18	0	0	18
NFKB1 protein, partial	13	0	0	13
PPM1D protein	9	0	0	9
SMAD family member 3	13	0	0	13
Thrombopoietin	13	0	0	13
caspase 7, apoptosis-related cysteine protease	13	0	0	13
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11	0	0	11
progesterone receptor	33	0	0	33
EWS/FLI fusion protein	33	0	0	33
farnesoid X nuclear receptor	26	0	0	26
pregnane X nuclear receptor	40	0	0	40
G	24	0	0	24
cytochrome P450 2D6	40	0	0	40
polyprotein	18	0	0	18
caspase-3	13	0	0	13
v-jun sarcoma virus 17 oncogene homolog (avian)	28	0	0	28
cytochrome P450 2D6 isoform 1	18	0	0	18
cytochrome P450 2C9 precursor	9	0	0	9
D(1A) dopamine receptor	30	0	0	30
chromobox protein homolog 1	33	0	0	33
heat shock protein beta-1	13	0	0	13
huntingtin isoform 2	13	0	0	13
serine/threonine-protein kinase mTOR isoform 1	21	0	0	21
cytochrome P450 3A4 isoform 1	22	0	0	22
muscarinic acetylcholine receptor M1	31	0	0	31
lethal factor (plasmid)	17	0	0	17
Gamma-aminobutyric acid receptor subunit pi	22	10	6	38
Polyunsaturated fatty acid lipoxygenase ALOX15B	17	0	0	17
Voltage-dependent L-type calcium channel subunit alpha-1C	0	7	0	7
Solute carrier organic anion transporter family member 1A4	0	4	0	7
Voltage-dependent L-type calcium channel subunit alpha-1F	0	17	0	17
5-hydroxytryptamine receptor 4	0	44	0	44
Lysine-specific demethylase PHF2	0	1	0	1
Interferon beta	34	0	0	34
HLA class I histocompatibility antigen, B alpha chain	24	0	0	24
Thyroid hormone receptor alpha	0	1	0	1
Tyrosine-protein kinase Fyn	0	5	0	5
ATP-dependent translocase ABCB1	0	7	0	7
Aldo-keto reductase family 1 member B1	0	41	0	41
Muscarinic acetylcholine receptor M2	0	34	6	46
Muscarinic acetylcholine receptor M4	0	34	4	42
ATP-dependent translocase ABCB1	0	28	2	46
Muscarinic acetylcholine receptor M5	0	36	3	43
Alpha-2A adrenergic receptor	0	43	4	49
Cytochrome P450 2C8	0	4	0	4
Thyroid hormone receptor alpha	0	3	3	6
Thyroid hormone receptor beta	0	3	3	6
Muscarinic acetylcholine receptor M1	0	39	5	50
D(2) dopamine receptor	0	34	5	46
Androgen receptor	0	6	0	6
Gamma-aminobutyric acid receptor subunit beta-1	22	10	6	38
Alpha-1B adrenergic receptor	0	30	5	35
Lethal factor	0	2	0	2
Alpha-2B adrenergic receptor	0	37	2	41
Thyroid hormone receptor beta	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	22	10	6	38
Gamma-aminobutyric acid receptor subunit gamma-2	22	10	8	40
Gamma-aminobutyric acid receptor subunit alpha-5	22	10	6	38
Gamma-aminobutyric acid receptor subunit alpha-3	22	10	6	38
Muscarinic acetylcholine receptor M3	0	36	5	45
ATP-dependent translocase ABCB1	0	7	0	8
Substance-K receptor	0	8	0	8
D(1A) dopamine receptor	0	27	2	32
D(4) dopamine receptor	0	18	2	25
Gamma-aminobutyric acid receptor subunit gamma-1	22	10	6	38
Gamma-aminobutyric acid receptor subunit alpha-2	22	10	6	38
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Histamine H2 receptor	0	23	2	25
Endothelin-1 receptor	0	3	1	4
5-hydroxytryptamine receptor 2A	0	43	2	47
5-hydroxytryptamine receptor 2C	0	46	2	48
Gamma-aminobutyric acid receptor subunit alpha-4	22	10	6	38
Gamma-aminobutyric acid receptor subunit gamma-3	22	10	6	38
Lysine-specific demethylase 5A	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	22	10	6	38
B2 bradykinin receptor	0	2	0	2
Melanocortin receptor 4	0	6	0	6
C-8 sterol isomerase	0	2	0	2
Melanocortin receptor 5	0	8	0	8
Mu-type opioid receptor	0	16	5	21
D(3) dopamine receptor	0	39	5	51
Sodium channel protein type 1 subunit alpha	0	7	0	7
Sodium channel protein type 4 subunit alpha	0	8	0	9
Squalene synthase	0	1	0	1
Delta-type opioid receptor	0	9	2	11
Kappa-type opioid receptor	0	11	2	13
5-hydroxytryptamine receptor 2B	0	47	2	49
C-C chemokine receptor type 2	0	6	0	6
Melanocortin receptor 3	0	6	0	6
Alpha-1A adrenergic receptor	0	32	6	38
Histamine H2 receptor	20	3	2	30
D(1A) dopamine receptor	16	2	0	18
5-hydroxytryptamine receptor 6	0	33	1	35
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
C-C chemokine receptor type 4	0	4	0	4
Spike glycoprotein	31	3	4	38
Gamma-aminobutyric acid receptor subunit alpha-1	22	11	8	41
Gamma-aminobutyric acid receptor subunit beta-3	22	10	6	38
Gamma-aminobutyric acid receptor subunit beta-2	22	10	8	40
Sodium channel protein type 7 subunit alpha	0	7	0	7
Voltage-dependent L-type calcium channel subunit alpha-1D	0	17	0	17
Potassium voltage-gated channel subfamily H member 2	0	48	1	49
Voltage-dependent L-type calcium channel subunit alpha-1S	0	17	0	17
Voltage-dependent L-type calcium channel subunit alpha-1C	0	20	0	21
Sodium channel protein type 5 subunit alpha	0	16	0	16
Squalene monooxygenase	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	12	0	12
Lysine-specific demethylase 7A	0	1	0	1
GABA theta subunit	22	10	6	38
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
Inositol hexakisphosphate kinase 1	24	0	0	24
Sodium channel protein type 2 subunit alpha	0	8	0	8
Sigma non-opioid intracellular receptor 1	0	35	1	36
Gamma-aminobutyric acid receptor subunit epsilon	22	10	6	38
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	0	1	1
Sodium channel protein type 3 subunit alpha	0	9	0	9
Sodium channel protein type 11 subunit alpha	0	6	0	6
Histone lysine demethylase PHF8	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	7	0	7
Sodium channel protein type 10 subunit alpha	0	6	0	6
cytochrome P450 2C9, partial	24	0	0	24
Chain A, HADH2 protein	14	0	0	14
Chain B, HADH2 protein	14	0	0	14
cytochrome P450 family 3 subfamily A polypeptide 4	42	0	0	42
atrial natriuretic peptide receptor 2 precursor	11	0	0	11
Solute carrier family 22 member 1	0	23	0	26
Albumin	0	0	10	10
High affinity nerve growth factor receptor	0	1	2	3
Muscarinic acetylcholine receptor M1	0	15	2	21
Muscarinic acetylcholine receptor M3	0	13	2	18
Muscarinic acetylcholine receptor M4	0	12	1	16
5-hydroxytryptamine receptor 2C	0	18	0	18
Muscarinic acetylcholine receptor M5	0	12	1	16
Muscarinic acetylcholine receptor M2	0	15	2	21
Angiotensin-converting enzyme	0	28	0	29
5-hydroxytryptamine receptor 2A	0	20	0	20
Alpha-2C adrenergic receptor	0	33	3	38
5-hydroxytryptamine receptor 1A	0	40	4	45
D(1B) dopamine receptor	0	6	1	10
UDP-glucuronosyltransferase 1A4	0	2	0	7
Alpha-1D adrenergic receptor	0	38	5	46
5-hydroxytryptamine receptor 1B	0	32	0	32
5-hydroxytryptamine receptor 1D	0	9	0	9
5-hydroxytryptamine receptor 1F	0	9	0	9
5-hydroxytryptamine receptor 2B	0	16	1	17
5-hydroxytryptamine receptor 6	0	4	0	4
Histamine H1 receptor	0	9	1	10
5-hydroxytryptamine receptor 7	0	9	0	9
5-hydroxytryptamine receptor 5A	0	4	0	4
5-hydroxytryptamine receptor 5B	0	4	0	4
Histamine H1 receptor	0	30	4	36
UDP-glucuronosyltransferase 1A3	0	0	0	2
5-hydroxytryptamine receptor 3A	0	5	0	5
5-hydroxytryptamine receptor 7	0	13	0	13
Voltage-dependent N-type calcium channel subunit alpha-1B	0	5	0	5
Sigma non-opioid intracellular receptor 1	0	4	3	7
5-hydroxytryptamine receptor 4	0	4	0	4
Nuclear receptor subfamily 3 group C member 3	0	22	0	22
5-hydroxytryptamine receptor 3B	0	5	0	5
Histamine H3 receptor	0	8	2	10
Chain A, Ferritin light chain	12	0	0	12
Smad3	11	0	0	11
NEDD8-activating enzyme E1 regulatory subunit isoform a	0	1	0	1
NEDD8-conjugating enzyme Ubc12	0	1	0	1
Potassium channel subfamily K member 2	0	6	6	12
Alpha-2B adrenergic receptor	0	19	5	24
Voltage-dependent L-type calcium channel subunit alpha-1C	0	6	0	6
Alpha-2C adrenergic receptor	0	19	5	24
Alpha-2A adrenergic receptor	0	19	5	24
Alpha-1A adrenergic receptor	0	16	6	27
Alpha-1B adrenergic receptor	0	13	5	21
Potassium channel subfamily K member 2	0	2	0	2
glucocerebrosidase	15	0	0	15
Atrial natriuretic peptide receptor 3	0	1	0	1
Type-1A angiotensin II receptor	0	2	1	3
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	2	0	2
Type-1 angiotensin II receptor	0	3	3	6
Type-2 angiotensin II receptor	0	4	0	4
Type-2 angiotensin II receptor	0	2	0	2
Bloom syndrome protein isoform 1	20	0	0	20
neuropeptide S receptor isoform A	8	0	0	8
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
alpha-galactosidase	4	0	0	4
cytochrome P450 2C19 precursor	10	0	0	10
Cytochrome P450 3A4	0	18	0	22
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	2
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	0	1	4
Cationic amino acid transporter 3	0	1	0	1
5-hydroxytryptamine receptor 3E	0	2	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	7	0	0	7
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	19	0	0	19
lysosomal alpha-glucosidase preproprotein	6	0	0	6
mu-type opioid receptor isoform MOR-1	0	0	3	3
transcriptional regulator ERG isoform 3	5	0	0	5
5-hydroxytryptamine receptor 2A	0	0	3	3
Solute carrier family 22 member 2	0	7	0	8
5-hydroxytryptamine receptor 3A	0	2	1	3
5-hydroxytryptamine receptor 3B	0	2	0	2
5-hydroxytryptamine receptor 1A	0	12	5	17
Neuronal acetylcholine receptor subunit alpha-4	4	3	0	7
Neuronal acetylcholine receptor subunit beta-2	4	3	0	7
D	0	15	0	15
Alpha-1D adrenergic receptor	0	21	5	26
D(4) dopamine receptor	0	11	0	11
Histamine H1 receptor	0	6	3	10
5-hydroxytryptamine receptor 7	0	7	1	8
5-hydroxytryptamine receptor 3A	0	2	0	2
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	3	0	3
D(2) dopamine receptor	0	22	0	23
5-hydroxytryptamine receptor 3D	0	2	0	2
Multidrug and toxin extrusion protein 2	0	5	0	5
5-hydroxytryptamine receptor 3C	0	2	0	2
Multidrug and toxin extrusion protein 1	0	12	0	12
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	24	0	0	24
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	7	0	0	7
hypothetical protein, conserved	3	0	0	3
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Prostaglandin-H2 D-isomerase	0	2	0	2
Solute carrier family 22 member 6	0	5	0	5
Prostaglandin G/H synthase 1	0	3	0	4
Prostaglandin G/H synthase 2	0	3	0	4
Carbonic anhydrase 1	0	16	0	21
Carbonic anhydrase 2	0	17	1	23
Fatty acid-binding protein, liver	0	5	0	5
Myeloperoxidase	0	2	0	2
Prostaglandin G/H synthase 1	0	6	0	7
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	9	0	9
Substance-P receptor	0	3	0	3
Prostaglandin G/H synthase 2	0	7	1	8
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	5	0	5
Rho-associated protein kinase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	5	1	6
Chain A, Beta-lactamase	15	0	0	15
nonstructural protein 1	10	0	0	10
bromodomain adjacent to zinc finger domain 2B	12	0	0	12
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	26	0	0	26
activating transcription factor 6	17	0	0	17
thyrotropin-releasing hormone receptor	5	0	0	5
Caspase-7	6	0	0	6
Spike glycoprotein	0	3	4	7
Replicase polyprotein 1ab	0	3	4	7
caspase-3	6	0	0	6
ubiquitin-conjugating enzyme E2 N	0	3	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
Transmembrane protease serine 2	0	3	4	7
Polycomb protein EED	0	2	0	2
HLA class I histocompatibility antigen, A alpha chain	0	0	2	2
Tyrosine-protein kinase Lck	0	2	0	2
Procathepsin L	0	4	4	8
Replicase polyprotein 1a	0	3	4	7
Replicase polyprotein 1ab	0	3	4	7
Replicase polyprotein 1ab	0	6	4	10
Replicase polyprotein 1ab	0	7	4	11
Glycine receptor subunit alpha-1	0	0	4	4
Substance-P receptor	0	3	0	3
Somatostatin receptor type 2	0	1	0	1
Somatostatin receptor type 4	0	1	0	1
Somatostatin receptor type 3	0	1	0	1
Somatostatin receptor type 5	0	1	0	1
Cytochrome P450 2J2	0	19	0	21
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Sigma intracellular receptor 2	0	2	0	2
Angiotensin-converting enzyme 2	0	5	4	9
Histamine H4 receptor	0	4	3	7
Heparanase	0	0	2	2
Beta-1 adrenergic receptor	0	2	7	11
Urease	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	1	2
Small conductance calcium-activated potassium channel protein 3	0	1	1	2
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	5	0	0	5
short transient receptor potential channel 6 isoform 1	0	0	3	3
Muscarinic acetylcholine receptor M1	0	1	1	3
Muscarinic acetylcholine receptor M4	0	1	0	1
Reverse transcriptase/RNaseH	0	1	2	4
Muscarinic acetylcholine receptor	0	3	2	6
thioredoxin glutathione reductase	5	0	0	5
P53	1	0	0	1
peripheral myelin protein 22 isoform 1	14	0	0	14
hemoglobin subunit beta	4	0	0	4
M-phase phosphoprotein 8	16	0	0	16
muscleblind-like protein 1 isoform 1	8	0	0	8
Bile salt export pump	0	16	0	16
Protein-arginine deiminase type-4	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 2	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 2	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 1	0	2	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	7	0	0	7
caspase-1 isoform alpha precursor	2	0	0	2
Caspase-7	2	0	0	2
Solute carrier organic anion transporter family member 1B3	0	7	0	9
Solute carrier organic anion transporter family member 1B1	0	10	0	13
Beta-1 adrenergic receptor	0	4	1	5
Potassium channel subfamily K member 3	0	3	0	3
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 9	0	1	0	1
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Integrin alpha-5	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	4	0	9
Neuronal acetylcholine receptor subunit beta-2	0	2	0	3
UDP-glucuronosyltransferase 1-6	0	2	0	3
Cytochrome P450 2B6	0	0	1	3
UDP-glucuronosyltransferase 1A1	0	4	0	5
Sodium-dependent dopamine transporter	0	21	0	21
Neuronal acetylcholine receptor subunit beta-4	0	1	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Cytochrome P450 2C19	0	5	0	6
UDP-glucuronosyltransferase 2B10	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	2
Acetylcholine receptor subunit delta	0	1	0	1
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	8	0	0	8
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	4	0	4
Cholinesterase	0	7	0	7
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Amine oxidase [flavin-containing] A	0	4	0	4
Acetylcholinesterase	0	9	0	10
Amine oxidase [flavin-containing] B	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	8	1	10
Vasopressin V2 receptor	0	0	0	2
Serine/threonine-protein kinase mTOR	0	2	0	2
Adenosine receptor A2a	0	2	0	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	2	0	2
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	2	0	2
Adenylate cyclase type 1	0	0	0	2
Chitotriosidase-1	0	2	0	2
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	2	0	2
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	3	4
Endochitinase B1	0	2	0	2
Phosphodiesterase	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	8	1	10
Guanine deaminase	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Luciferase	14	0	0	14
15-lipoxygenase, partial	7	0	0	7
Cruzipain	0	2	0	2
Type-1 angiotensin II receptor	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	7	7
NEDD8-activating enzyme E1 regulatory subunit	0	1	1	2
NEDD8-activating enzyme E1 catalytic subunit	0	0	1	1
DNA polymerase kappa	0	1	0	1
DNA polymerase iota	0	1	0	1
DNA polymerase eta	0	1	0	1
Liver carboxylesterase 1	0	1	0	5
Chain A, angiotensin converting enzyme	0	1	0	1
Chain A, angiotensin converting enzyme	0	1	0	1
Metallo-beta-lactamase type 2	0	1	1	3
transient receptor potential cation channel subfamily V member 1	3	0	0	3
Prothrombin	0	2	1	3
Neprilysin	0	1	0	1
Neprilysin	0	1	0	1
Leukotriene A-4 hydrolase	0	2	1	3
EEF1AKMT4-ECE2 readthrough transcript protein	0	1	0	1
Angiotensin-converting enzyme	0	5	1	6
Leukotriene A-4 hydrolase	0	1	0	1
Thymidine phosphorylase	0	0	1	1
Endothelin-converting enzyme 1	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	3	0	3
Angiotensin-converting enzyme	0	4	0	4
Solute carrier family 15 member 1	0	2	0	2
Beta-lactamase TEM	0	2	0	3
Mu-type opioid receptor	0	5	1	6
Beta-lactamase	0	2	0	3
Beta-lactamase	0	2	0	2
Beta-lactamase class B VIM-2	0	1	1	3
GALC protein	4	0	0	4
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Delta-type opioid receptor	0	8	0	9
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Muscarinic acetylcholine receptor M3	0	0	1	3
Muscarinic acetylcholine receptor M2	0	0	0	3
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Vpr	4	0	0	4
Major prion protein	0	0	4	4
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	3	0	3
Cytochrome P450 2C9	0	20	0	21
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	2	0	2
Lactoperoxidase	0	2	0	2
Chain A, serum paraoxonase	0	1	0	1
Carbonic anhydrase 12	0	7	0	10
Carbonic anhydrase 3	0	7	0	8
Neutrophil cytosol factor 1	0	1	0	1
Carbonic anhydrase 4	0	10	0	13
Carbonic anhydrase 6	0	9	0	12
Carbonic anhydrase 5A, mitochondrial	0	11	1	15
Carbonic anhydrase 7	0	8	0	11
Carbonic anhydrase 9	0	11	0	15
Carbonic anhydrase 13	0	5	0	6
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
Carbonic anhydrase 14	0	6	0	9
Carbonic anhydrase 5B, mitochondrial	0	9	0	12
endonuclease IV	6	0	0	6
Glutathione reductase, mitochondrial	0	3	0	3
Alpha-synuclein	3	0	0	3
Glutathione reductase	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	7	0	0	7
Toll-like receptor 4	0	1	0	1
Amyloid-beta precursor protein	2	3	0	5
Potassium channel subfamily K member 10	0	1	0	1
Cytochrome P450 1B1	0	2	0	2
D(3) dopamine receptor isoform e	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	0	5
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	5
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	0	5
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	0	8	5	13
Translocator protein	0	4	1	6
Gamma-aminobutyric acid receptor subunit gamma-2	0	8	4	12
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	0	5
Gamma-aminobutyric acid receptor subunit beta-3	0	8	4	12
Cholecystokinin receptor type A	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	7	5	12
Gamma-aminobutyric acid receptor subunit alpha-3	0	7	4	11
Gamma-aminobutyric acid receptor subunit alpha-2	0	7	4	11
Proteasome subunit beta type-11	0	0	0	1
NADPH oxidase 1	0	1	0	1
Snq2p	0	0	0	2
Adenylate cyclase type 1	0	4	0	4
ras-related protein Rab-9A	9	0	0	9
Proteasome subunit alpha type-7	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Transient receptor potential cation channel subfamily V member 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Albumin	0	4	8	13
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Major prion protein	0	0	1	1
Cytochrome P450 1A2	0	3	1	4
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	4	1	5
Cytochrome P450 2D6	0	15	1	17
Polyunsaturated fatty acid lipoxygenase ALOX15	0	6	0	6
Sphingomyelin phosphodiesterase	0	1	0	1
D(3) dopamine receptor	0	14	0	14
D(2) dopamine receptor	0	6	0	6
Proteasome subunit beta type-1	0	0	0	1
Adenylate cyclase type 3	0	4	0	4
D(1B) dopamine receptor	0	10	0	10
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	4	0	4
Adenylate cyclase type 4	0	4	0	4
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
Trypanothione reductase	0	6	0	6
Pleiotropic ABC efflux transporter of multiple drugs	0	2	0	4
Glutamate receptor ionotropic, NMDA 1	0	5	2	8
Adenylate cyclase type 8	0	4	0	4
Proteasome subunit beta type-10	0	0	0	1
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
Gastrin/cholecystokinin type B receptor	0	3	0	3
Proteasome subunit alpha type-6	0	0	2	3
Calmodulin	0	1	3	4
Aldehyde oxidase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	5	2	8
Glutamate receptor ionotropic, NMDA 2B	0	5	2	8
Glutamate receptor ionotropic, NMDA 2C	0	5	2	8
Adenylate cyclase type 6	0	4	0	4
Adenylate cyclase type 5	0	4	0	4
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Aldehyde oxidase	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	5	2	8
Adenylyl cyclase 7	0	4	0	4
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	5	2	8
D	0	4	0	4
Proteasome subunit beta type-7	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	5	2	8
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	5	0	5
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	3	0	3
cGMP-specific 3',5'-cyclic phosphodiesterase	0	4	0	5
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	4	0	5
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	4	0	5
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	4	0	6
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	4	0	5
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	5	0	6
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	3	0	3
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	5	0	6
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	8	1	10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	7	0	8
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	6	0	7
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	7	0	8
Trypanothione reductase	0	1	0	1
Envelope glycoprotein	0	0	3	3
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	2	0	0	2
Alpha-1B adrenergic receptor	0	0	1	1
Membrane primary amine oxidase	0	1	0	1
Solute carrier family 22 member 3	0	5	0	6
Alpha-1A adrenergic receptor	0	2	1	3
Alpha-2B adrenergic receptor	0	2	0	3
Alpha-2C adrenergic receptor	0	2	0	3
Alpha-2A adrenergic receptor	0	2	0	3
Alpha-2A adrenergic receptor	0	2	0	2
Nischarin	0	2	0	2
Solute carrier family 22 member 1	0	7	0	8
Nischarin	0	1	0	1
Beta-2 adrenergic receptor	0	8	1	10
Beta-1 adrenergic receptor	0	9	3	14
Endothelin receptor type B	0	1	0	1
5-hydroxytryptamine receptor 3A	0	2	0	2
Endothelin receptor type B	0	1	0	1
Beta-3 adrenergic receptor	0	5	1	6
Sodium-dependent serotonin transporter	0	15	1	17
5-hydroxytryptamine receptor 2C	0	3	0	3
5-hydroxytryptamine receptor 2A	0	3	0	3
5-hydroxytryptamine receptor 5A	0	1	0	1
D(2) dopamine receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
D(2) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	3	0	3
5-hydroxytryptamine receptor 4	0	2	0	2
Transporter	0	4	0	4
Cholecystokinin receptor type A	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Transporter	0	10	0	10
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	6	0	6
Gamma-aminobutyric acid receptor subunit delta	0	6	0	6
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	1	2
Tryptophan 5-hydroxylase 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	6	2	8
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	6	4	10
Gamma-aminobutyric acid receptor subunit alpha-4	0	6	2	8
Gamma-aminobutyric acid receptor subunit epsilon	0	6	0	6
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	7	1	8
Leukotriene B4 receptor 1	0	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	6	2	8
Sodium-dependent dopamine transporter	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	0	6	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	0	6	1	7
Leukotriene B4 receptor 2	0	1	0	2
Gamma-aminobutyric acid receptor subunit theta	0	6	0	6
Matrix metalloproteinase-9	0	2	0	2
Isocitrate lyase	0	1	0	1
Thymidine kinase 2	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	0	0	1
AAA family ATPase	0	0	0	1
Solute carrier family 22 member 3	0	2	0	2
Histamine H3 receptor	0	1	0	1
Solute carrier family 22 member 2	0	4	0	5
Solute carrier family 22 member 4	0	1	0	1
Gamma-aminobutyric acid	0	1	1	2
Alpha-1-acid glycoprotein 1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
PAX8	0	0	0	1
STAT3, partial	0	1	0	1
NPC intracellular cholesterol transporter 1 precursor	6	0	0	6
tumor necrosis factor	2	0	0	2
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	3
Solute carrier organic anion transporter family member 4C1	0	0	0	2
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Potassium voltage-gated channel subfamily A member 1	0	3	0	3
Histamine N-methyltransferase	0	0	0	1
Calcium release-activated calcium channel protein 1	0	1	0	1
Protein orai-2	0	1	0	1
Protein orai-3	0	1	0	1
Histamine H3 receptor	0	1	0	2
apical membrane antigen 1, AMA1	5	0	0	5
pyruvate kinase	1	0	0	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
LacZ protein (plasmid)	0	0	1	1
beta-2 adrenergic receptor	4	0	0	4
type-1 angiotensin II receptor	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
runt-related transcription factor 1 isoform AML1b	1	0	0	1
perilipin-5	0	2	0	2
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
perilipin-1	0	2	0	2
core-binding factor subunit beta isoform 2	1	0	0	1
polypyrimidine tract-binding protein 1 isoform a	1	0	0	1
apelin receptor	0	2	0	2
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	2	0	2
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase	0	1	0	1
pyruvate kinase PKM isoform b	1	0	0	1
Fatty-acid amide hydrolase 1	0	3	0	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	2
Carbamate kinase	0	1	0	1
Retinal dehydrogenase 1	0	1	0	1
Aldehyde dehydrogenase, mitochondrial	0	1	0	1
Ornithine decarboxylase	1	0	0	1
Fructose-1,6-bisphosphatase 1	0	1	0	1
C-X-C chemokine receptor type 2	0	2	0	2
Mitogen-activated protein kinase 3	0	1	0	1
Protein-lysine 6-oxidase	0	1	0	1
Caspase-1	0	2	0	3
C-C chemokine receptor type 5	0	4	0	4
Gasdermin-D	0	1	0	1
Lysyl oxidase homolog 3	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Lysyl oxidase homolog 4	0	1	0	1
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Monoglyceride lipase	0	2	0	2
Gasdermin-D	0	1	0	1
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
heat shock protein 90, putative	0	0	0	1
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
large T antigen	0	1	0	1
dopamine D1 receptor	1	0	0	1
POU domain, class 2, transcription factor 1	0	0	0	2
Carbonic anhydrase 15	0	4	0	5
Nuclear receptor subfamily 1 group I member 2	0	0	4	4
L-lactate dehydrogenase A chain	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Glutamate receptor 1	0	1	1	2
Glutamate receptor 3	0	1	1	2
Glutamate receptor 4	0	1	1	2
Cannabinoid receptor 1	0	2	1	4
Cannabinoid receptor 2	0	2	1	4
Cannabinoid receptor 1	0	1	0	1
Cannabinoid receptor 2	0	1	1	2
N-arachidonyl glycine receptor	0	0	1	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Lysophosphatidylserine lipase ABHD12	0	1	0	1
Monoacylglycerol lipase ABHD6	0	1	0	1
Cannabinoid receptor 2	0	2	0	2
G-protein coupled receptor 55	0	1	1	2
Solute carrier family 15 member 1	0	3	0	3
Solute carrier organic anion transporter family member 1A1	0	1	0	2
Potassium voltage-gated channel subfamily A member 5	0	3	0	3
Potassium voltage-gated channel subfamily D member 2	0	2	0	2
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
Solute carrier family 22 member 8	0	2	0	4
Thymidylate synthase	0	1	0	1
Aromatase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Dipeptidyl peptidase 4	0	2	0	2
Acetylcholinesterase	0	4	0	4
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Sigma intracellular receptor 2	0	4	0	4
Sodium-dependent serotonin transporter	0	2	0	2
Chain A, probable fosfomycin resistance protein	0	0	1	1
Chain B, probable fosfomycin resistance protein	0	0	1	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase alpha catalytic subunit	0	1	0	1
DNA polymerase delta catalytic subunit	0	1	0	1
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Protein Rev	0	0	1	1
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Serum paraoxonase/arylesterase 1	0	3	0	3
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Sodium/bile acid cotransporter	0	2	0	2
Carbonic anhydrase 13	0	2	0	5
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	2	3
Histone deacetylase 3	0	3	0	3
Sodium- and chloride-dependent GABA transporter 1	0	4	0	4
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	4	0	4
Sodium- and chloride-dependent GABA transporter 3	0	4	0	4
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	4	0	4
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Histone deacetylase 4	0	3	0	3
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	3	0	3
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	3	0	3
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Histone deacetylase 8	0	3	0	3
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Cocaine esterase	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	1	0	5
Vitamin D-binding protein	0	1	0	1
Integrin beta-1	0	1	0	1
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
Mu-type opioid receptor	0	7	0	7
Kappa-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	4	0	5
5-hydroxytryptamine receptor 2A	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Protease	0	3	0	3
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Plasma kallikrein	0	0	0	1
Macrophage migration inhibitory factor	0	2	0	2
5-hydroxytryptamine receptor 1D	0	1	0	2
Metabotropic glutamate receptor 5	0	1	1	2
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase	0	2	0	4
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase	0	2	0	4
Equilibrative nucleoside transporter 4	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	1	0	2
Carboxylic ester hydrolase	0	2	0	3
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	3	0	3
Acid-sensing ion channel 3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Albumin	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	4
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	3
Aldo-keto reductase family 1 member C3	0	3	0	3
Caspase-3	0	1	0	1
Caspase-4	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Fatty-acid amide hydrolase 1	0	3	0	3
Prostaglandin G/H synthase 2	0	2	0	3
Solute carrier family 22 member 6	0	2	0	2
Prostaglandin G/H synthase 1	0	2	0	3
Solute carrier family 22 member 8	0	3	0	3
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Parkin	3	0	0	3
Prostaglandin E synthase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	3	0	3
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Interleukin-8	0	1	0	1
Androgen receptor	0	3	1	4
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Aldo-keto reductase family 1 member C4	0	1	0	1
Thromboxane-A synthase	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Multidrug resistance-associated protein 1	0	3	1	5
Bifunctional epoxide hydrolase 2	0	2	0	2
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	3
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
hexokinase-4 isoform 1	2	0	0	2
glucokinase regulatory protein	2	0	0	2
Beta-2 adrenergic receptor	0	0	1	1
Beta-adrenergic receptor kinase 1	0	1	3	4
Beta-3 adrenergic receptor	0	0	1	1
Vasopressin V1a receptor	0	0	1	1
Beta-2 adrenergic receptor	0	4	0	4
Taste receptor type 2 member 38	0	0	1	1
Taste receptor type 2 member 39	0	0	1	1
Taste receptor type 2 member 40	0	0	1	1
Taste receptor type 2 member 41	0	0	1	1
Taste receptor type 2 member 43	0	0	1	1
Taste receptor type 2 member 31	0	0	2	2
Taste receptor type 2 member 45	0	0	1	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 30	0	0	1	1
Taste receptor type 2 member 19	0	0	1	1
Taste receptor type 2 member 20	0	0	1	1
Taste receptor type 2 member 50	0	0	1	1
Taste receptor type 2 member 60	0	0	2	2
Oxytocin receptor	0	0	1	1
Taste receptor type 2 member 42	0	0	1	1
Taste receptor type 2 member 16	0	0	1	1
Taste receptor type 2 member 14	0	0	2	2
Taste receptor type 2 member 13	0	0	2	2
Taste receptor type 2 member 10	0	0	1	1
Taste receptor type 2 member 9	0	0	2	2
Taste receptor type 2 member 8	0	0	1	1
Taste receptor type 2 member 7	0	0	1	1
Taste receptor type 2 member 5	0	0	1	1
Taste receptor type 2 member 4	0	0	2	2
Taste receptor type 2 member 3	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	0	0	2	2
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	0	0	2	2
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	0	0	2	2
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Synaptic vesicle glycoprotein 2A	0	2	0	2
Potassium channel subfamily K member 18	0	1	0	1
Kappa-type opioid receptor	0	1	1	2
Mu-type opioid receptor	0	1	1	2
Amine oxidase [flavin-containing] B	0	3	0	3
Amine oxidase [flavin-containing] B	0	1	0	1
Synaptic vesicular amine transporter	0	2	0	2
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Polyphenol oxidase 2	0	2	0	3
Dopamine beta-hydroxylase	0	2	0	2
Lanosterol 14-alpha demethylase	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Glucocorticoid receptor	0	6	2	13
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Phosphodiesterase	0	3	0	3
Aurora kinase A	0	1	0	1
Dual specificity protein kinase TTK	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	5	0	5
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
Aurora kinase B	0	1	0	1
Inner centromere protein	0	1	0	1
Phosphodiesterase	0	2	0	2
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	2
voltage-dependent T-type calcium channel subunit alpha-1H isoform a	0	0	1	1
Atrial natriuretic peptide receptor 1	0	1	0	1
Acetylcholinesterase	0	7	0	8
Cholinesterase	0	6	1	8
eyes absent homolog 2 isoform a	1	0	0	1
Phospholipase A2, membrane associated	0	0	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 2	0	2	0	2
Class D beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	2	0	2
MecA	0	1	0	1
MBT domain-containing protein 1	0	1	0	1
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
Quinolone resistance protein NorA	0	2	0	3
Beta-adrenergic receptor kinase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	2	0	2
Rhodopsin kinase GRK1	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
P2X purinoceptor 4	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
Beta-adrenergic receptor kinase 1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
streptokinase A precursor	0	0	2	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase VIM-1	0	0	0	1
Acetylcholinesterase	0	3	0	3
Acetylcholinesterase	0	3	0	3
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	2	0	2
Cholinesterase	0	2	0	2
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Carboxylic ester hydrolase	0	2	0	2
Sodium/potassium/calcium exchanger 4	0	1	1	2
Sodium/potassium/calcium exchanger 2	0	1	1	2
interferon gamma precursor	0	0	0	1
Alpha-1A adrenergic receptor	0	1	1	2
Beta-casein	0	1	0	1
Interstitial collagenase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	2	0	2
Alpha-mannosidase 2C1	0	0	1	1
Bromodomain-containing protein 2	0	2	0	2
5-hydroxytryptamine receptor 1B	0	3	1	4
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	2	0	2
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Chloroquine resistance transporter	0	2	0	2
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Neuromedin-K receptor	0	0	1	1
Cholecystokinin receptor type A	0	1	1	2
Vasopressin V1a receptor	0	1	1	2
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
DNA topoisomerase 1	0	2	0	2
Chromaffin granule amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	2	1	3
Synaptic vesicular amine transporter	0	1	0	1
Chain A, Activated Factor Xa Heavy Chain	0	1	0	1
Coagulation factor X	0	2	0	2
Coagulation factor XII	0	1	0	1
Suppressor of tumorigenicity 14 protein	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Acetylcholine receptor subunit epsilon	0	1	0	1
Cholinesterase	0	1	0	1
Tyrosine-protein kinase SYK	0	1	0	1
Beta-secretase 1	0	1	0	1
Retina-specific copper amine oxidase	0	1	0	1
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	0	1	0	1
Tumor necrosis factor	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	2	0	2
Endothelin-1 receptor	0	1	0	1
Phosphodiesterase	0	1	0	1
Protein cereblon	0	2	0	2
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
Neutral amino acid transporter A	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Transcriptional activator protein LuxR	0	2	0	2
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	1	0	1
C-X-C chemokine receptor type 5 isoform 1	0	1	0	1
C-C chemokine receptor type 6	0	1	0	1
bcl-2-related protein A1	0	1	0	1
Endoglycoceramidase II	0	0	0	1
Protein kinase C alpha type	0	1	0	1
Estrogen receptor	0	0	1	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor beta	0	0	1	1
Protein kinase C eta type	0	1	0	1
Sphingosine kinase 2	0	1	0	1
Sphingosine kinase 1	0	1	0	1
Protein kinase C theta type	0	1	0	1
Sphingosine 1-phosphate receptor 2	0	1	1	2
Sphingosine 1-phosphate receptor 4	0	1	1	2
Sphingosine 1-phosphate receptor 1	0	1	1	2
Sphingosine 1-phosphate receptor 3	0	1	1	2
Sphingosine 1-phosphate receptor 5	0	1	1	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	2	0	2
Delta carbonic anhydrase	0	2	0	2
D(2) dopamine receptor	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
XBP1	0	1	0	1
DNA damage-inducible transcript 3 protein	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
cGMP-gated cation channel alpha-1	0	0	1	1
Chain A, Pyridoxal kinase	0	1	0	1
Chain A, Pyridoxal Kinase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
Adenosine receptor A1	0	2	0	2
Adenosine receptor A1	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Proliferating cell nuclear antigen	0	2	0	2
Retinoic acid receptor RXR-alpha	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Glycoprotein	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
ClpP	1	0	0	1
POsterior Segregation	0	0	1	1
Estrogen receptor beta	0	1	0	1
Estrogen receptor	0	1	0	1
M-phase inducer phosphatase 1	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Zinc finger protein mex-5	0	0	1	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Amine oxidase [flavin-containing]	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (275)

Protein Targets (1,464)

Sinus Tachycardia

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (275)

Drugs Studied (213)

Protein Targets (1,464)