n-(2,6-difluorophenyl)-5-methyl(1,2,4)-triazol(1,5-a)pyrimidine-2-sulfonamide profile

ID Source	ID
PubMed CID	91759
CHEMBL ID	1389671
CHEBI ID	82011
SCHEMBL ID	54906
MeSH ID	M0447647

Synonym
HMS2576I16
MLS000704301
smr000231089
AK-105/40832077
n-(2,6-difluorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
NCGC00163836-01
(1,2,4)triazolo(1,5-a)pyrimidine-2-sulfonamide, n-(2,6-difluorophenyl)-5-methyl-
de 498
xrd 498
n-(2,6-difluorophenyl)-5-methyl-(1,2,4)triazolo(1,5-a)pyrimidine-2-sulfonamide
epa pesticide chemical code 129016
broadstrike
flumetsulam
98967-40-9
NCGC00163836-02
n-(2,6-difluorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
n-[2,6-bis(fluoranyl)phenyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
A845938
NCGC00163836-03
C18852
dtxcid2012615
cas-98967-40-9
NCGC00254732-01
dtxsid4032615 ,
tox21_300828
AKOS015917292
x89f0s6lw8 ,
2',6'-difluoro-5-methyl(1,2,4)triazolo(1,5-a)pyrimidine-2-sulfoanilide
n-(2,6-difluorophenyl)-5-methyl(1,2,4)-triazol(1,5-a)pyrimidine-2-sulfonamide
ec 619-383-6
flumetsulam [ansi]
hsdb 8439
unii-x89f0s6lw8
FT-0642383
SCHEMBL54906
CHEMBL1389671
chebi:82011 ,
n-(2,6-difluorophenyl)-5-methyl(1,2,4)triazolo(1,5-a)pyrimidine-2-sulfonamide
flumetsulam [mi]
2',6'-difluoro-5-methyl(1,2,4)triazolo(1,5-a)pyrimidine-2-sulfonanilide
python (dow agrosci.)
broadstrike (dow agrosci.)
de-498
n-(2,6-difluorophenyl)-5-methyl-1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamide
5-methyl-n-(2,6-difluorophenyl)-1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamide
bdbm50004708
KS-5373
AC-27543
mfcd04089841
n-(2,6-difluorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidine-2-sulphonamide
flumetsulam, pestanal(r), analytical standard
flumetsulam, analytical standard
flumetsulam 100 microg/ml in acetonitrile
Q26840836
CS-W021043

Excerpt	Relevance	Reference
" Whole-plant dose-response studies showed that the purified subpopulation was highly resistant to chlorsulfuron, metosulam and imazamox, with LD₅₀ or GR₅₀ R/S ratio of > 1024, > 512 and > 137 respectively."	( A novel amino acid substitution Ala-122-Tyr in ALS confers high-level and broad resistance across ALS-inhibiting herbicides. Friesen, S; Han, H; Li, M; Powles, SB; Purba, E; Walsh, M; Yu, Q, 2012)	0.38

Class	Description
sulfonamide	An amide of a sulfonic acid RS(=O)2NR'2.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
ClpP	Bacillus subtilis	Potency	31.6228	1.9953	22.6730	39.8107	AID651965
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	0.0969	0.0060	38.0041	19,952.5996	AID1159521
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	2.4541	0.0002	29.3054	16,493.5996	AID743075
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	11.2202	0.0355	20.9770	89.1251	AID504332
thyroid hormone receptor beta isoform a	Homo sapiens (human)	Potency	0.0035	0.0100	39.5371	1,122.0200	AID588547
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	27.3060	0.0003	23.4451	159.6830	AID743065
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Acetolactate synthase	Nicotiana tabacum (common tobacco)	IC50 (µMol)	0.4850	0.0316	0.4850	0.9385	AID1100697; AID1100698
Acetolactate synthase	Raphanus raphanistrum	IC50 (µMol)	34.4387	0.0070	2.9264	6.8380	AID1112484; AID1112486; AID1112487
Acetolactate synthase, chloroplastic	Arabidopsis thaliana (thale cress)	Ki	0.3600	0.0080	0.7264	3.0000	AID1091923
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (52)

Assay ID	Title	Year	Journal	Article
AID1091899	Post-emergence herbicidal activity against Rumex acetosa assessed as growth inhibition at 37.5 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1091900	Post-emergence herbicidal activity against Amaranthus retroflexus assessed as growth inhibition at 75 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1091922	Post-emergence herbicidal activity against Echinochloa crus-galli (barnyard grass) assessed as growth inhibition at 150 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1112486	Inhibition of ALS in ALS-herbicide-susceptible Raphanus raphanistrum WARR7 (wild radish)	2012	Pest management science, Aug, Volume: 68, Issue:8	A novel amino acid substitution Ala-122-Tyr in ALS confers high-level and broad resistance across ALS-inhibiting herbicides.
AID1091921	Post-emergence herbicidal activity against Digitaria sanguinalis (hairy crabgrass) assessed as growth inhibition at 150 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1091906	Post-emergence herbicidal activity against Cyperus iria assessed as growth inhibition at 75 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1112493	Herbicidal activity against two to three leaf stage ALS-herbicide-resistant Raphanus raphanistrum WARR30 (wild radish) expressing ALS Ala122Tyr mutant assessed as reduction in survival measured 3 weeks after compound treatment	2012	Pest management science, Aug, Volume: 68, Issue:8	A novel amino acid substitution Ala-122-Tyr in ALS confers high-level and broad resistance across ALS-inhibiting herbicides.
AID1091909	Post-emergence herbicidal activity against Cerastium arvense assessed as growth inhibition at 75 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1091902	Post-emergence herbicidal activity against Chenopodium album assessed as growth inhibition at 150 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1091914	Post-emergence herbicidal activity against Galium aparine assessed as growth inhibition at 75 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1091901	Post-emergence herbicidal activity against Amaranthus retroflexus assessed as growth inhibition at 37.5 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1091916	Post-emergence herbicidal activity against Galium aparine assessed as growth inhibition at 37.5 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1091911	Post-emergence herbicidal activity against Polygonum humifusum assessed as growth inhibition at 150 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1091908	Post-emergence herbicidal activity against Cerastium arvense assessed as growth inhibition at 150 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1091904	Post-emergence herbicidal activity against Chenopodium album assessed as growth inhibition at 37.5 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1091896	Post-emergence herbicidal activity against Eclipta prostrata assessed as growth inhibition at 37.5 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1112485	Resistance index, ratio of I50 for ALS Ala122Tyr mutant in ALS-herbicide-resistant Raphanus raphanistrum WARR30 (wild radish) expressing ALS Ala122Tyr mutant to I50 for ALS-herbicide-susceptible Raphanus raphanistrum (wild radish)	2012	Pest management science, Aug, Volume: 68, Issue:8	A novel amino acid substitution Ala-122-Tyr in ALS confers high-level and broad resistance across ALS-inhibiting herbicides.
AID1091913	Post-emergence herbicidal activity against Polygonum humifusum assessed as growth inhibition at 37.5 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1091915	Post-emergence herbicidal activity against Galium aparine assessed as growth inhibition at 150 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1091917	Post-emergence herbicidal activity against Eclipta prostrata assessed as growth inhibition at 150 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1112492	Herbicidal activity against two to three leaf stage ALS-herbicide-susceptible Raphanus raphanistrum WARR7 (wild radish) assessed as reduction in survival measured 3 weeks after compound treatment	2012	Pest management science, Aug, Volume: 68, Issue:8	A novel amino acid substitution Ala-122-Tyr in ALS confers high-level and broad resistance across ALS-inhibiting herbicides.
AID1091905	Post-emergence herbicidal activity against Cyperus iria assessed as growth inhibition at 150 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1091897	Post-emergence herbicidal activity against Rumex acetosa assessed as growth inhibition at 150 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1091919	Post-emergence herbicidal activity against Brassica juncea assessed as growth inhibition at 150 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1091903	Post-emergence herbicidal activity against Chenopodium album assessed as growth inhibition at 75 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1091910	Post-emergence herbicidal activity against Cerastium arvense assessed as growth inhibition at 37.5 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1091895	Post-emergence herbicidal activity against Eclipta prostrata assessed as growth inhibition at 75 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1112484	Inhibition of ALS in ALS-herbicide-susceptible Raphanus raphanistrum WARR33 (wild radish)	2012	Pest management science, Aug, Volume: 68, Issue:8	A novel amino acid substitution Ala-122-Tyr in ALS confers high-level and broad resistance across ALS-inhibiting herbicides.
AID1091918	Post-emergence herbicidal activity against Amaranthus retroflexus assessed as growth inhibition at 150 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1112487	Inhibition of ALS Ala122Tyr mutant in ALS-herbicide-resistant Raphanus raphanistrum WARR30 (wild radish) expressing ALS Ala122Tyr mutant	2012	Pest management science, Aug, Volume: 68, Issue:8	A novel amino acid substitution Ala-122-Tyr in ALS confers high-level and broad resistance across ALS-inhibiting herbicides.
AID1100698	Inhibition of wild type Nicotiana tabacum (tobacco) GST-tagged acetolactate synthase expressed in Escherichia coli by modified Westerfeld method	1999	Biochemical and biophysical research communications, May-19, Volume: 258, Issue:3	Synthesis of the quinoline-linked triazolopyrimidine analogues and their interactions with the recombinant tobacco acetolactate synthase.
AID1091920	Post-emergence herbicidal activity against Poa annua assessed as growth inhibition at 150 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1100697	Inhibition of wild type Nicotiana tabacum (tobacco) S4-Hra GST-tagged acetolactate synthase mutant expressed in Escherichia coli by modified Westerfeld method	1999	Biochemical and biophysical research communications, May-19, Volume: 258, Issue:3	Synthesis of the quinoline-linked triazolopyrimidine analogues and their interactions with the recombinant tobacco acetolactate synthase.
AID1091912	Post-emergence herbicidal activity against Polygonum humifusum assessed as growth inhibition at 75 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1091907	Post-emergence herbicidal activity against Cyperus iria assessed as growth inhibition at 37.5 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1091923	Inhibition of wild type Arabidopsis thaliana acetolactate synthase by colorimetry	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1112490	Herbicidal activity against two to three leaf stage ALS-herbicide-resistant Raphanus raphanistrum WARR30 (wild radish) expressing ALS Ala122Tyr mutant assessed as reduction in dry weight of above-ground biomass measured 3 weeks after compound treatment	2012	Pest management science, Aug, Volume: 68, Issue:8	A novel amino acid substitution Ala-122-Tyr in ALS confers high-level and broad resistance across ALS-inhibiting herbicides.
AID1091898	Post-emergence herbicidal activity against Rumex acetosa assessed as growth inhibition at 75 g ai/ha measured 15 days post compound treatment under green house conditions	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.
AID1112489	Herbicidal activity against two to three leaf stage ALS-herbicide-susceptible Raphanus raphanistrum WARR7 (wild radish) assessed as reduction in dry weight of above-ground biomass measured 3 weeks after compound treatment	2012	Pest management science, Aug, Volume: 68, Issue:8	A novel amino acid substitution Ala-122-Tyr in ALS confers high-level and broad resistance across ALS-inhibiting herbicides.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812	Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID504810	Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (5.00)	18.2507
2000's	6 (30.00)	29.6817
2010's	9 (45.00)	24.3611
2020's	4 (20.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	21 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
urea pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.	2.13	1	isourea; monocarboxylic acid amide; one-carbon compound	Daphnia magna metabolite; Escherichia coli metabolite; fertilizer; flour treatment agent; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
diuron Diuron: A pre-emergent herbicide.. diuron : A member of the class of 3-(3,4-substituted-phenyl)-1,1-dimethylureas that is urea in which both of the hydrogens attached to one nitrogen are substituted by methyl groups, and one of the hydrogens attached to the other nitrogen is substituted by a 3,4-dichlorophenyl group.	2.06	1	3-(3,4-substituted-phenyl)-1,1-dimethylurea; dichlorobenzene	environmental contaminant; mitochondrial respiratory-chain inhibitor; photosystem-II inhibitor; urea herbicide; xenobiotic
2-methyl-4-chlorophenoxyacetic acid 2-Methyl-4-chlorophenoxyacetic Acid: A powerful herbicide used as a selective weed killer.. (4-chloro-2-methylphenoxy)acetic acid : A chlorophenoxyacetic acid that is (4-chlorophenoxy)acetic acid substituted by a methyl group at position 2.	2.13	1	chlorophenoxyacetic acid; monochlorobenzenes	environmental contaminant; phenoxy herbicide; synthetic auxin
linuron Linuron: A selective pre- and post-emergence herbicide. (From Merck Index, 11th ed). linuron : A member of the class of phenylureas that is N-methyl urea substituted by a methoxy group at position 1 and a 3,4-dichlorophenyl group at position 3.	2.06	1	dichlorobenzene; phenylureas	agrochemical; environmental contaminant; herbicide; xenobiotic
gold Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.	2.25	1	copper group element atom; elemental gold
chlorsulfuron chlorsulfuron: RN given refers to parent cpd; structure given in first source. chlorsulfuron : An N-sulfonylurea that is N-carbamoyl-2-chlorobenzenesulfonamide in which one of the hydrogens attached to the non-sulfonylated nitrogen has been replaced by a 4-methoxy-6-methyl-1,3,5-triazin-2-yl group. A herbicide used for the control of broadleaf weeds in wheat, barley and oats.	2.07	1	methoxy-1,3,5-triazine; monochlorobenzenes; N-sulfonylurea	agrochemical; EC 2.2.1.6 (acetolactate synthase) inhibitor; herbicide
fomesafen fomesafen: a protoporphyrinogen oxidase-inhibiting herbicide. fomesafen : An N-sulfonylcarboxamide that is N-(methylsulfonyl)benzamide in which the phenyl ring is substituted by a nitro group at position 2 and a 2-chloro-4-(trifluoromethyl)phenoxy group at position 5. A protoporphyrinogen oxidase inhibitor, it was specially developed for use (generally as the corresponding sodium salt, fomesafen-sodium) for post-emergence control of broad-leaf weeds in soya.	2.06	1	aromatic ether; C-nitro compound; monochlorobenzenes; N-sulfonylcarboxamide; organofluorine compound; phenols	agrochemical; EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor; herbicide
lovastatin Lovastatin: A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.. lovastatin : A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom).	2.41	1	delta-lactone; fatty acid ester; hexahydronaphthalenes; polyketide; statin (naturally occurring)	anticholesteremic drug; antineoplastic agent; Aspergillus metabolite; prodrug
imazapyr, (+-)-isomer imazapyr: RN given refers to parent cpd without isomeric designation. imazapyr : A racemate comprising equimolar amounts of (R)- and (S)-imazapyr. An inhibitor of acetohydroxyacid synthase, it is used (generally as the isopropylamine salt, known as imazapyr-isopropylammonium) as a herbicide, particularly for the control of perennial grasses, broad-leaved weeds, woody plants, brambles, etc., on non-crop land. It is not approved for use within the European Union.. 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)nicotinic acid : A pyridinemonocarboxylic acid that is nicotinic acid which is substituted at position 2 by a 4,5-dihydro-imidazol-2-yl group, which in turn is substituted at positions 4, 4, and 5 by isopropyl, ethyl, and oxo groups, respectively.	2.07	1	imidazolines; imidazolone; pyridinemonocarboxylic acid; pyridines
imazethapyr imazethapyr: do not confuse with imazapyr, which is the 5-desethyl analog of imazethapyr	2.07	1	aromatic carboxylic acid; pyridines
triazoles Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.	2.01	1	1,2,3-triazole
raptors imazamox: an experimental imidazolinone herbicide; structure in first source. 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)-5-(methoxymethyl)nicotinic acid : A pyridinemonocarboxylic acid that is nicotinic acid which is substituted substituted at position 5 by a methoxymethyl group and at position 2 by a 4,5-dihydro-1H-imidazol-2-yl group, that in turn is substituted by isopropyl, methyl, and oxo groups at positions 4, 4, and 5, respectively.. imazamox : A racemate composed of equimolar amounts of (S)- and (R)-imazamox. An inhibitor of acetohydroxyacid synthase, it is used (particularly as the corresponding ammonium salt, known as imazamox-ammonium) as a herbicide for the control of grass, broad-leaf weeds, and pond weed.	2.07	1	ether; imidazolines; imidazolone; pyridinemonocarboxylic acid
3-amino-5-mercapto-1,2,4-triazole 3-amino-5-mercapto-1,2,4-triazole: structure in first source	2.01	1
florasulam florasulam: structure in first source	2.11	1	sulfonamide

Condition	Relationship Strength	Studies
Innate Inflammatory Response [description not available]	2.05	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.05	1
Airway Hyper-Responsiveness [description not available]	2.01	1

n-(2,6-difluorophenyl)-5-methyl(1,2,4)-triazol(1,5-a)pyrimidine-2-sulfonamide

Cross-References

Synonyms (55)

Research Excerpts

Dosage Studied

Drug Classes (1)

Protein Targets (9)

Potency Measurements

Inhibition Measurements

Bioassays (52)

Research

Studies (20)

Market Indicators

Research Demand Index: 12.35

Study Types

n-(2,6-difluorophenyl)-5-methyl(1,2,4)-triazol(1,5-a)pyrimidine-2-sulfonamide

Cross-References

Synonyms (55)

Research Excerpts

Dosage Studied

Drug Classes (1)

Protein Targets (9)

Potency Measurements

Inhibition Measurements

Bioassays (52)

Research

Studies (20)

Market Indicators

Research Demand Index: 12.35

Study Types

Related Drugs (14)

Related Conditions (3)