Methallibure: A dithiobiurea compound with anti-gonadotropic activity. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 3003791 |
| CHEMBL ID | 2106852 |
| SCHEMBL ID | 393014 |
| MeSH ID | M0013548 |
| Synonym |
|---|
| compound 33,828 |
| ai3-51056 |
| ay 61122 |
| metalliburum [latin] |
| biurea, 2,5-dithio-1-methyl-6-(1-methyl-2-propenyl)- |
| i.c.i. compound 33828 |
| i.c.i. 33,828 |
| nsc 69536 |
| ici 33,828 |
| 1alpha-methylallylthiocarbamoyl-2-methylthiocarbamoylhydrazine |
| biurea, 1-methyl-6-(1-methylallyl)-2,5-dithio- |
| einecs 213-146-7 |
| 1-alpha-methylallylthiocarbamoyl-2-methylthiocarbamoylhydrazine |
| metalibura [inn-spanish] |
| n-((1-methylallyl)thiocarbamoyl)-n'-(methylthiocarbamoyl)hydrazine |
| metallibur |
| metalliburum [inn-latin] |
| 1,2-hydrazinedicarbothioamide, n-methyl-n'-(1-methyl-2-propenyl)- |
| metalibura [spanish] |
| brn 1212512 |
| wln: suym1&mmyus&my1u1 |
| 1-methyl-6-(1-methylallyl)dithiobiurea |
| metallibure |
| ay-61122 |
| 1-[(.alpha.-methylallyl)thiocarbamoyl]-2-(methylthiocarbamoyl)hydrazine |
| n-[(1-methylallyl)thiocarbamoyl]-n'-(methylthiocarbamoyl)hydrazine |
| turisynchron |
| 926-93-2 |
| aimax |
| 2,5-dithio-1-methyl-6-(1-methyl-2-propenyl)biurea |
| ici 33828 |
| methallibure |
| 1, n-methyl-n'-(1-methyl-2-propenyl)- |
| suisynchron |
| ici-33,828 |
| nsc-69536 |
| 1-methyl-6-(1-methylallyl)-2,5-dithiobiurea |
| match |
| almax |
| biurea,5-dithio-1-methyl-6-(1-methyl-2-propenyl)- |
| nsc69536 |
| 1, 2-hydrazinedicarbothioamide, n-methyl-n'-(1-methyl-2-propenyl)- |
| 1-methyl-3-(1-methylallylcarbamothioylamino)thiourea |
| .meta.llibure |
| {n-[(1-methylallyl)thiocarbamoyl]-n'-(methylthiocarbamoyl)hydrazine} |
| biurea, 1-methyl-6-(1-methylallyl)-2, 5-dithio- |
| biurea, 2, 5-dithio-1-methyl-6-(1-methyl-2-propenyl)- |
| {1-[(.alpha.-methylallyl)thiocarbamoyl]-2-(methylthiocarbamoyl)hydr} azine |
| n~1~-methyl-n~2~-(1-methyl-2-propenyl)-1,2-hydrazinedicarbothioamide |
| methallibure (usan/inn) |
| D04975 |
| NCIOPEN2_003498 |
| 1-but-3-en-2-yl-3-(methylcarbamothioylamino)thiourea |
| metalliburum |
| metallibure [inn] |
| mbu5xj97c4 , |
| unii-mbu5xj97c4 |
| metalibura |
| methallibure [usan] |
| CHEMBL2106852 |
| ici-33828 |
| methallibure [mi] |
| metallibure [mart.] |
| SCHEMBL393014 |
| AKOS024403844 |
| CGFFKDRVHZIQHL-UHFFFAOYSA-N |
| Z1269236938 |
| aimax; ici 33828; methallibure |
| Q27283830 |
| 3-(but-3-en-2-yl)-1-[(methylcarbamothioyl)amino]thiourea |
| DTXSID70862475 |
| CS-0026371 |
| n-methyl-n'-(1-methyl-2-propenyl)-1,2-hydrazinedicarbothioamide |
| EN300-1268098 |
Methallibure treatment is as effective as hypophysectomy in reducing thyroid activity in H. Cyprinus carpio causes a marked reduction in the steroidogenesis, as indicated by the fall in 3beta-HSD activity in the gonads.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Methallibure treatment may exert marked inhibitory influence on vitellogenesis in the fish and cause atresia of vitellogenic follicles, the oogonial proliferation is stepped up." | ( The effect of methallibure (I.C.I., 33828) on the ovary of the carp, Cyprinus carpio. Kapur, K, 1980) | 1.34 |
| "Methallibure treatment is as effective as hypophysectomy in reducing thyroid activity in H. " | ( Thyroid activity in response to some gonadal steroids in methallibure-treated Heteropneustes fossilis (Bloch). Raizada, RB; Singh, TP, 1979) | 1.95 |
| "Methallibure treatment of mature Cyprinus carpio causes a marked reduction in the steroidogenesis, as indicated by the fall in 3beta-HSD activity in the gonads. " | ( The effect of methallibure (I.C.I. 33,828) on the steriodogenesis in the ovary and testis of a fresh water teleost, Cyprinus carpio. Kapur, K; Toor, HS, 1978) | 2.06 |
| "Methallibure treatment (1 mg fed on alternate days to a female and a male kept in 1 liter of 25% seawater) started from 1 or 7 days postpartum (early gestation) inhibited gestation in the wild guppy, Poecilia reticulata. " | ( Effect of methallibure on gestation in the guppy, Poecilia reticulata. Lam, TJ; Ng, KL; Pavri, C, 1985) | 2.11 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " Clinical inspection, weight gain, haematological findings, blood sugar, serum transaminases, properties of urine and faeces, carcass examination and histological study (internal organs, endocrine glands, skeletal muscle) showed that the 1 mg/kg dosage had no toxic effect." | ( [Effect of long-term application of SUISYNCHRON-premix on swine]. Chemnitius, KH; Oettel, M; Schimke, E; Zieger, M, 1974) | 0.25 |
| "Twelve groups of German Edelschwein were given the recommended dosage of metallibure zinc complex (SUISYNCHRON) or 5 and 10 times this dosage." | ( [Pharmacologic-endocrinological findings in animal experiments with TURISYNCHRON and SUISYNCHRON. 4. Analysis of residuals in pig carcasses]. Chemnitius, KH; Claussen, C; Grass, M; Räche, K; Steiner, G, 1974) | 0.25 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 66 (92.96) | 18.7374 |
| 1990's | 4 (5.63) | 18.2507 |
| 2000's | 1 (1.41) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (15.15) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 2 (2.74%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 71 (97.26%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||