triazoles has been researched along with Aura in 82 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (2.44) | 18.7374 |
1990's | 13 (15.85) | 18.2507 |
2000's | 22 (26.83) | 29.6817 |
2010's | 36 (43.90) | 24.3611 |
2020's | 9 (10.98) | 2.80 |
Authors | Studies |
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Liu, D; Wang, Y | 1 |
Chen, L; Hou, Z; Huang, L; Li, X; Lian, C; Meng, Q; Wang, Y; Wu, J; Yu, H; Zhang, C | 1 |
Imai, K; Inoue, Y; Kagawa, Y; Takahashi, Y; Usui, N; Yamamoto, Y | 1 |
Abou Tayoun, A; Goldberg, EM; Zaman, T | 1 |
Bozarth, XL; Oesch, G | 1 |
Barbieri, R; Bertelli, S; Gavazzo, P; Pusch, M | 1 |
Cummins, TR; Mason, ER | 1 |
Andrys, R; Angeli, A; Czarnomysy, R; Kaproń, B; Musilek, K; Plech, T; Supuran, CT; Wysokiński, M | 1 |
Caraballo, RH; Espeche, A; Fasulo, L; Galichio, S; Pociecha, J; Reyes, G; Semprino, M | 1 |
Beccaria, F; Capovilla, G; De Giorgis, V; Fattore, C; Franco, V; Galimberti, CA; Gatti, G; Johannessen Landmark, C; Marchiselli, R; Mazzucchelli, I; Perucca, E; Rota, P | 1 |
Loddenkemper, T; Tanritanir, A; Wang, X | 1 |
Bebin, EM; Cutter, GR; Gaston, TE; Liu, Y; Szaflarski, JP | 1 |
Deng, XQ; Song, MX | 1 |
Mahendran, G; Vijayan, R | 1 |
Baker, EM; George, AL; Hawkins, NA; Kearney, JA; Meisler, MH; Patel, MK; Thompson, CH; Wagnon, JL; Wengert, ER | 1 |
Battaglia, D; Coppola, G; Curatolo, P; Cusmai, R; D'Aniello, A; Di Gennaro, G; Matricardi, S; Moavero, R; Parisi, P; Pruna, D; Spalice, A; Verrotti, A; Vigevano, F | 1 |
Bosmans, F; Diaz-Bustamante, M; Dutton, S; Escayg, A; Gilchrist, J; Kalia, J; McPherson, A; Olivares, N | 1 |
Ito, S; Oguni, H | 1 |
Ohtsuka, Y | 1 |
Accorsi, P; Balestri, P; Coppola, G; Dontin, SD; Gobbi, G; Grosso, S; Parisi, P; Pruna, D; Verrotti, A | 1 |
Besag, F; Coppola, G; Curatolo, P; Cusmai, R; Dulac, O; Kluger, G; Moavero, R; Nabbout, R; Nikanorova, M; Pisani, F; Verrotti, A; von Stülpnagel, C | 1 |
Bergin, AM; Bolton, J; Bourgeois, BF; Harini, C; Kadish, NE; Kapur, K; Kothare, SV; Libenson, M; Loddenkemper, T; Olson, H; Peters, J; Poduri, A; Ramgopal, S; Rotenberg, A; Sánchez Fernández, I; Takeoka, M; Thome-Souza, S | 1 |
Alsaad, AM; Koren, G | 1 |
Guan, LP; Quan, ZS | 1 |
Awaya, T; Heike, T; Ide, M; Kato, T; Nakata, M; Saito, K; Yoshida, T | 1 |
Dhanda, A; Kamboj, VK; Ranjan, S; Verma, PK | 1 |
Cnaan, A; Dlugos, DJ; Kessler, SK; McCarthy, A | 1 |
Ayati, A; Emami, S; Foroumadi, A | 1 |
Arcella, A; Cantore, G; Di Gennaro, G; Esposito, V; Eusebi, F; Fredholm, BB; Fucile, S; Limatola, C; Manfredi, M; Martinello, K; Mascia, A; Miledi, R; Piccari, V; Quarato, PP; Roseti, C; Simonato, M | 1 |
Bast, T; Boor, R; Ernst, JP; Haberlandt, E; Kluger, G; Kurlemann, G; Makowski, C; Runge, U; Schneider, F | 2 |
Stafstrom, CE | 1 |
Verdian, L; Yi, Y | 1 |
Conry, J; Krauss, G; LoPresti, A; Mann, A; Narurkar, M; Wheless, JW | 1 |
Albani, F; Baruzzi, A; Candela, C; Contin, M; Mohamed, S; Riva, R | 1 |
Bromfield, EB; Drislane, FW; Dworetzky, BA; Farina, EL; Fowler, KM; Herzog, AG; Schomer, DL; Smithson, SD | 1 |
Best, R; Hutchinson, DJ; Liou, Y; Zhao, F | 1 |
Arroyo, S; Glauser, T; Kluger, G; Krauss, G; Perdomo, C; Seeruthun, R | 1 |
Wisniewski, CS | 1 |
Balestri, A; Coppola, G; Curatolo, P; D'Aniello, A; Fels, A; Franzoni, E; Grosso, S; Habetswallner, F; Mangano, S; Parisi, P; Pascotto, A; Spalice, A; Veggiotti, P; Verrotti, A; Zamponi, N | 1 |
Bergin, AM; Bourgeois, BF; Duffy, FH; Eksioglu, YZ; Gooty, VD; Kothare, SV; Libenson, M; Loddenkemper, T; Poduri, A; Rotenberg, A; Takeoka, M; Vendrame, M | 1 |
Falchi, M; Filippi, L; Guerrini, R; Innocenti, M; la Marca, G; Malvagia, S; Moneti, G; Pellacani, S; Rosati, A | 1 |
Joseph, JR; Schultz, RJ; Wilfong, AA | 1 |
Bergin, AM; Bourgeois, BF; Coulter, D; Duffy, FH; Kothare, SV; Libenson, MH; Loddenkemper, T; Olson, HE; Poduri, A; Rotenberg, A; Takeoka, M; Vendrame, M | 1 |
Perucca, E; Prunetti, P | 1 |
Ballone, E; Chiarelli, F; Curatolo, P; Loiacono, G; Mattei, PA; Verrotti, A | 1 |
Antzelevitch, C; Borggrefe, M; Brandt, C; Ebner, A; Göksu, T; Kuschyk, J; Papavassiliu, T; Rudic, B; Schimpf, R; Veltmann, C; Wolpert, C | 1 |
Crespel, A; Gelisse, P; Mourand, I | 1 |
Dahlin, MG; Ohman, I | 1 |
Kadaba, PK | 1 |
Chimirri, A; De Sarro, A; De Sarro, G; Ferreri, G; Gitto, R; Orlando, V; Quartarone, S; Russo, E | 1 |
Nawrot, M | 1 |
BAJER, A; SAHANEK, O | 1 |
Disteldorf, E; Jarry, H; Lehan, N; Mares, U; Rune, GM; von Lossow, R; Wehrenberg, U; Zhou, L | 1 |
Anderson, GD; Cheng-Hakimian, A; Miller, JW | 1 |
Arroyo, S | 1 |
Chai, KY; Jin, YZ; Li, FN; Li, G; Quan, ZS; Sun, XY | 1 |
Anderson, GD; Cheng-Hakimian, A; Hakimian, S; Miller, JW | 1 |
Heaney, D; Walker, MC | 1 |
Kreutzkamp, B | 1 |
Arroyo, S; Glauser, T; Kluger, G; Krauss, G; Perdomo, C; Sachdeo, R | 1 |
Cloyd, J; Critchley, D; Fuseau, E; Perucca, E | 1 |
Dailey, JW; Jo, M; Jobe, PC; Ko, KH; Seo, DO; Yan, QS | 1 |
Alif, L; Godbillon, J; Lecaillon, JB; Moes, D; Rouan, MC; Souppart, C | 1 |
Bialer, M; Johannessen, SI; Kupferberg, HJ; Levy, RH; Loiseau, P; Perucca, E | 1 |
Bac, P; Dupont, C; Evrard, P; Gressens, P; Maurois, P; Pages, N; Stables, JP; Vamecq, J | 1 |
Balon, R | 1 |
Dale, TJ; Dupere, JR; Starkey, SJ; Xie, X | 1 |
Jain, KK | 1 |
Canger, R; Henriksen, O; Karolchyk, MA; Pålhagen, S; Rivière, ME; van Parys, JA | 1 |
Aldenkamp, AP | 1 |
Meldrum, BS; Patel, S; White, HS | 1 |
Heinemann, U; Zhang, CL | 1 |
Ashton, D; Willems, R | 1 |
De Beukelaar, F; Tritsmans, L | 1 |
Czuczwar, SJ; Janusz, W; Kleinrok, Z; Szczepanik, B | 1 |
Hulsman, J; Rentmeester, T | 1 |
De Beukelaar, F; Overweg, J | 1 |
Baud, J; Benedict, M; Bischoff, S; Bittiger, H; Fagg, GE; Hauser, K; Meier, R; Portet, C; Schmutz, M; Thedinga, K | 1 |
24 review(s) available for triazoles and Aura
Article | Year |
---|---|
An Important Potential Anti-Epileptic/Anticonvulsant Active Group: A Review of 1,2,4-Triazole Groups and Their Action.
Topics: Anticonvulsants; Epilepsy; Humans; Seizures; Triazoles | 2022 |
Recent developments on triazole nucleus in anticonvulsant compounds: a review.
Topics: Anticonvulsants; Epilepsy; Humans; Molecular Structure; Triazoles | 2018 |
[Treatment of pediatric epilepsy].
Topics: Adolescent; Amines; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cyclohexanecarboxylic Acids; Dioxolanes; Drug Approval; Drug Substitution; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Infant; Lamotrigine; Levetiracetam; Patient Education as Topic; Piracetam; Practice Guidelines as Topic; Topiramate; Triazines; Triazoles; Valproic Acid | 2014 |
[New antiepileptic drugs: characteristics and clinical applications].
Topics: Amines; Anticonvulsants; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Dioxolanes; Drug Approval; Drug Interactions; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Japan; Lamotrigine; Levetiracetam; Piracetam; Safety; Topiramate; Triazines; Triazoles | 2014 |
Current role of rufinamide in the treatment of childhood epilepsy: literature review and treatment guidelines.
Topics: Anticonvulsants; Epilepsy; Female; Guidelines as Topic; Humans; Male; Triazoles | 2014 |
Exposure to rufinamide and risks of CNS adverse events in drug-resistant epilepsy: a meta-analysis of randomized, placebo-controlled trials.
Topics: Anticonvulsants; Central Nervous System Diseases; Disorders of Excessive Somnolence; Dizziness; Drug Resistance; Epilepsy; Fatigue; Headache; Humans; Randomized Controlled Trials as Topic; Risk; Triazoles | 2014 |
3,4-DHQLO and Triazole and Its Related Analogues with Anticonvulsant Effects.
Topics: Animals; Anticonvulsants; Drug Design; Epilepsy; Humans; Hydroquinones; Seizures; Structure-Activity Relationship; Triazoles | 2016 |
1,2,4-triazole derivatives as potential scaffold for anticonvulsant activity.
Topics: Animals; Anticonvulsants; Epilepsy; Humans; Seizures; Structure-Activity Relationship; Triazoles | 2015 |
The importance of triazole scaffold in the development of anticonvulsant agents.
Topics: Animals; Anticonvulsants; Drug Discovery; Epilepsy; Humans; Triazoles | 2016 |
Safety and tolerability of rufinamide in children with epilepsy: a pooled analysis of 7 clinical studies.
Topics: Adolescent; Age Factors; Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Disorders of Excessive Somnolence; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Female; Headache; Humans; Male; Treatment Outcome; Triazoles; Vomiting | 2009 |
Rufinamide: a new antiepileptic medication for the treatment of seizures associated with lennox-gastaut syndrome.
Topics: Aged; Anticonvulsants; Chemistry, Pharmaceutical; Child; Clinical Trials, Phase III as Topic; Counseling; Drug Resistance; Epilepsies, Partial; Epilepsy; Humans; Off-Label Use; Randomized Controlled Trials as Topic; Seizures; Syndrome; Triazoles | 2010 |
Rufinamide for refractory epilepsy in a pediatric and young adult population.
Topics: Adolescent; Age Factors; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Longitudinal Studies; Male; Treatment Outcome; Triazoles; Young Adult | 2011 |
New and forthcoming anti-epileptic drugs.
Topics: Acetamides; Anticonvulsants; Clinical Trials as Topic; Dioxolanes; Drug Approval; Drug Discovery; Epilepsy; Humans; Lacosamide; Remission Induction; Triazoles | 2011 |
Efficacy of rufinamide in drug-resistant epilepsy: a meta-analysis.
Topics: Anticonvulsants; Chi-Square Distribution; Dose-Response Relationship, Drug; Double-Blind Method; Epilepsy; Humans; Odds Ratio; Triazoles | 2011 |
Rational drug design and the discovery of the delta2-1,2,3-triazolines, a unique class of anticonvulsant and antiischemic agents.
Topics: Animals; Anticonvulsants; Brain Ischemia; Drug Design; Epilepsy; Humans; Pharmacokinetics; Stroke; Structure-Activity Relationship; Triazoles | 2003 |
Disorders of motion and depth.
Topics: Alzheimer Disease; Amblyopia; Antidepressive Agents; Cerebral Veins; Cues; Depth Perception; Epilepsy; Humans; Mesencephalon; Motion Perception; Occipital Lobe; Perceptual Disorders; Piperazines; Schizophrenia; Sinus Thrombosis, Intracranial; Temporal Lobe; Triazoles; Vestibular Diseases; Williams Syndrome | 2003 |
Rufinamide: CGP 33101, E 2080, RUF 331, Xilep.
Topics: Anticonvulsants; Clinical Trials as Topic; Drug Interactions; Drugs, Investigational; Epilepsy; Humans; Triazoles | 2005 |
Rufinamide: Pharmacology, clinical trials, and role in clinical practice.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Epilepsy; Humans; Triazoles | 2006 |
Rufinamide.
Topics: Animals; Anticonvulsants; Brain; Clinical Trials as Topic; Epilepsy; Humans; Triazoles | 2007 |
Rufinamide: a new anti-epileptic medication.
Topics: Adult; Animals; Anticonvulsants; Child; Drug Interactions; Epilepsy; Humans; Randomized Controlled Trials as Topic; Syndrome; Triazoles | 2007 |
Rufinamide.
Topics: Animals; Anticonvulsants; Drug Interactions; Epilepsy; Humans; Triazoles | 2007 |
[Rufinamide. An orphan drug for treatment of Lennox-Gastaut syndrome].
Topics: Anticonvulsants; Child, Preschool; Drug Interactions; Epilepsy; Female; Humans; Male; Syndrome; Triazoles | 2007 |
An assessment of rufinamide as an anti-epileptic in comparison with other drugs in clinical development.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Humans; Triazoles | 2000 |
Loreclezole.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drugs, Investigational; Electroencephalography; Epilepsy; Evoked Potentials; Humans; Triazoles | 1991 |
6 trial(s) available for triazoles and Aura
Article | Year |
---|---|
A comparison of anastrozole and testosterone versus placebo and testosterone for treatment of sexual dysfunction in men with epilepsy and hypogonadism.
Topics: Adolescent; Adult; Anastrozole; Aromatase Inhibitors; Double-Blind Method; Drug Therapy, Combination; Epilepsy; Humans; Hypogonadism; Injections, Intramuscular; Male; Middle Aged; Nitriles; Prospective Studies; Sexual Dysfunction, Physiological; Testosterone; Triazoles; Young Adult | 2010 |
Adjunctive rufinamide in Lennox-Gastaut syndrome: a long-term, open-label extension study.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; Epilepsy; Female; Humans; Longitudinal Studies; Male; Treatment Outcome; Triazoles; Young Adult | 2010 |
Rufinamide in refractory childhood epileptic encephalopathies other than Lennox-Gastaut syndrome.
Topics: Adolescent; Adult; Anticonvulsants; Brain Diseases; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Triazoles; Young Adult | 2011 |
Efficacy of rufinamide in drug-resistant epilepsy: a meta-analysis.
Topics: Anticonvulsants; Chi-Square Distribution; Dose-Response Relationship, Drug; Double-Blind Method; Epilepsy; Humans; Odds Ratio; Triazoles | 2011 |
Rufinamide for generalized seizures associated with Lennox-Gastaut syndrome.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy; Epilepsy, Absence; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Female; Humans; Male; Syndrome; Treatment Outcome; Triazoles | 2008 |
Rufinamide: a double-blind, placebo-controlled proof of principle trial in patients with epilepsy.
Topics: Adult; Anticonvulsants; Double-Blind Method; Drug Therapy, Combination; Epilepsy; Female; Half-Life; Humans; Incidence; Male; Middle Aged; Nervous System Diseases; Seizures; Triazoles | 2001 |
53 other study(ies) available for triazoles and Aura
Article | Year |
---|---|
Discovery of 7-alkyloxy- [1,2,4] triazolo[1,5-a] pyrimidine derivatives as selective positive modulators of GABA
Topics: Animals; Anticonvulsants; Cells, Cultured; Dose-Response Relationship, Drug; Drug Discovery; Electroshock; Epilepsy; Male; Mice; Mice, Inbred Strains; Molecular Structure; Neurons; Pentylenetetrazole; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Structure-Activity Relationship; Triazoles | 2022 |
Therapeutic Drug Monitoring for Rufinamide in Japanese Patients With Epilepsy: Focus on Drug Interactions, Tolerability, and Clinical Effectiveness.
Topics: Anticonvulsants; Drug Interactions; Drug Monitoring; Epilepsy; Humans; Japan; Retrospective Studies; Seizures; Treatment Outcome; Triazoles | 2022 |
A single-center SCN8A-related epilepsy cohort: clinical, genetic, and physiologic characterization.
Topics: Cell Culture Techniques; Child; Cohort Studies; Epilepsy; Female; HEK293 Cells; Humans; Infant; Infant, Newborn; Male; Mutation; NAV1.6 Voltage-Gated Sodium Channel; Oxcarbazepine; Pyridines; Seizures; Sodium Channels; Triazoles | 2019 |
Rufinamide efficacy and association with phenotype and genotype in children with intractable epilepsy: A retrospective single center study.
Topics: Anticonvulsants; Child; Child, Preschool; Drug Resistant Epilepsy; Epilepsy; Female; Genotype; Humans; Infant; Lennox Gastaut Syndrome; Male; Phenotype; Retrospective Studies; Seizures; Triazoles | 2020 |
Late sodium current blocker GS967 inhibits persistent currents induced by familial hemiplegic migraine type 3 mutations of the SCN1A gene.
Topics: Action Potentials; Epilepsy; HEK293 Cells; Humans; Migraine Disorders; Migraine with Aura; Mutation; NAV1.1 Voltage-Gated Sodium Channel; Neurons; Pyridines; Sodium; Triazoles | 2019 |
Differential Inhibition of Human Nav1.2 Resurgent and Persistent Sodium Currents by Cannabidiol and GS967.
Topics: Action Potentials; Animals; Anticonvulsants; Cannabidiol; Epilepsy; HEK293 Cells; Humans; Ion Channel Gating; Mice; Mutation; NAV1.2 Voltage-Gated Sodium Channel; Neurons; Protein Isoforms; Pyridines; Triazoles | 2020 |
1,2,4-Triazole-based anticonvulsant agents with additional ROS scavenging activity are effective in a model of pharmacoresistant epilepsy.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Antioxidants; Biphenyl Compounds; Butyrylcholinesterase; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Epilepsy; Humans; Mice; Models, Molecular; Molecular Structure; Oxidative Stress; Picrates; Reactive Oxygen Species; Structure-Activity Relationship; Triazoles | 2020 |
Rufinamide as add-on therapy in children with epileptic encephalopathies other than Lennox-Gastaut syndrome: A study of 34 patients.
Topics: Adolescent; Anticonvulsants; Argentina; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; Follow-Up Studies; Humans; Lennox Gastaut Syndrome; Male; Retrospective Studies; Seizures; Triazoles; Valproic Acid | 2020 |
Relationship between saliva and plasma rufinamide concentrations in patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Drug Monitoring; Epilepsy; Female; Humans; Male; Saliva; Triazoles; Young Adult | 2020 |
Efficacy and Tolerability of Rufinamide in Epileptic Children Younger Than 4 Years.
Topics: Age Factors; Anticonvulsants; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Retrospective Studies; Treatment Outcome; Triazoles | 2021 |
Interactions between cannabidiol and commonly used antiepileptic drugs.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Benzodiazepines; Cannabidiol; Child; Child, Preschool; Clobazam; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Female; Fructose; Humans; Male; Middle Aged; Topiramate; Triazoles; Young Adult | 2017 |
Neuropharmacological and molecular docking studies of xanthones from Swertia corymbosa.
Topics: Animals; Anticonvulsants; Anxiety; Electroshock; Epilepsy; Isoniazid; Male; Maze Learning; Mice; Molecular Docking Simulation; Motor Activity; Neuropharmacology; Rotarod Performance Test; Seizures; Serotonin; Swertia; Triazoles; Xanthones | 2018 |
The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy.
Topics: Action Potentials; Animals; Anticonvulsants; Brain Diseases; Disease Models, Animal; Drug Administration Schedule; Electroshock; Epilepsy; Female; Hippocampus; Humans; Male; Mice; Mice, Transgenic; Mutation; NAV1.6 Voltage-Gated Sodium Channel; Neurons; Off-Label Use; Phenytoin; Pyridines; Triazoles | 2018 |
Rufinamide for the treatment of refractory epilepsy secondary to neuronal migration disorders.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Germany; Humans; Italy; Male; Malformations of Cortical Development, Group II; Prospective Studies; Treatment Outcome; Triazoles; Young Adult | 2014 |
Nav1.1 modulation by a novel triazole compound attenuates epileptic seizures in rodents.
Topics: Action Potentials; Animals; Anticonvulsants; Cells, Cultured; Drug Discovery; Epilepsy; Hippocampus; Humans; Male; Mice; NAV1.1 Voltage-Gated Sodium Channel; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Triazoles; Xenopus | 2014 |
Efficacy and safety of rufinamide in children under four years of age with drug-resistant epilepsies.
Topics: Anticonvulsants; Child, Preschool; Electroencephalography; Epilepsy; Female; Follow-Up Studies; Humans; Infant; Male; Retrospective Studies; Treatment Outcome; Triazoles | 2014 |
Safety and retention rate of rufinamide in 300 patients: a single pediatric epilepsy center experience.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Cohort Studies; Drug Therapy, Combination; Epilepsy; Female; Follow-Up Studies; Humans; Infant; Male; Patient Compliance; Prospective Studies; Retrospective Studies; Sleep Wake Disorders; Treatment Outcome; Triazoles; Vomiting; Young Adult | 2014 |
A granulocytosis associated with rufinamide: A case report.
Topics: Agranulocytosis; Anticonvulsants; Child; Clonazepam; Epilepsy; Humans; Male; Triazoles; Valproic Acid | 2015 |
Retention rates of rufinamide in pediatric epilepsy patients with and without Lennox-Gastaut Syndrome.
Topics: Adolescent; Anticonvulsants; Child; Cohort Studies; Epilepsy; Female; Humans; Kaplan-Meier Estimate; Lennox Gastaut Syndrome; Male; Treatment Outcome; Triazoles | 2015 |
Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors.
Topics: Adenosine; Adenosine Deaminase; Adult; Animals; Anticonvulsants; Cerebral Cortex; Epilepsy; Female; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Male; Neurons; Oocytes; Purinergic P1 Receptor Antagonists; Pyramidal Tracts; Pyrimidines; Quinazolines; Rats; Receptors, GABA-A; Triazoles; Xanthines; Xenopus | 2008 |
Effectiveness and tolerability of rufinamide in children and adults with refractory epilepsy: first European experience.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Resistance; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Europe; Female; Humans; Infant; Male; Middle Aged; Orphan Drug Production; Retrospective Studies; Seizures; Treatment Outcome; Triazoles; Young Adult | 2009 |
American Epilepsy Society--62nd Annual Meeting. 5-9 December 2008, Seattle, USA.
Topics: Animals; Anticonvulsants; Biomarkers; Clinical Trials as Topic; Epilepsy; Humans; Infant; Ketones; Societies, Scientific; Spasms, Infantile; Triazoles; United States | 2009 |
Rufinamide (Banzel) for epilepsy.
Topics: Anticonvulsants; Clinical Trials as Topic; Drug Interactions; Epilepsy; Humans; Treatment Outcome; Triazoles | 2009 |
Rufinamide: Further evaluation is needed in Lennox-Gastaut syndrome.
Topics: Adult; Child; Clinical Trials as Topic; Drug Approval; Epilepsy; Europe; Humans; Orphan Drug Production; Seizures; Triazoles | 2008 |
Cost-utility analysis of rufinamide versus topiramate and lamotrigine for the treatment of children with Lennox-Gastaut Syndrome in the United Kingdom.
Topics: Anticonvulsants; Child; Confidence Intervals; Cost-Benefit Analysis; Drug Utilization; Epilepsy; Follow-Up Studies; Fructose; Health Status; Humans; Lamotrigine; Markov Chains; Quality of Life; Sensitivity and Specificity; Topiramate; Triazines; Triazoles; United Kingdom | 2010 |
Simultaneous HPLC-UV analysis of rufinamide, zonisamide, lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in deproteinized plasma of patients with epilepsy.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Felbamate; Humans; Isoxazoles; Lamotrigine; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Triazines; Triazoles; Ultraviolet Rays; Zonisamide | 2010 |
Stability of extemporaneously prepared rufinamide oral suspensions.
Topics: Adult; Anticonvulsants; Child; Chromatography, High Pressure Liquid; Drug Compounding; Drug Packaging; Drug Stability; Drug Storage; Epilepsy; Humans; Pharmaceutical Vehicles; Polypropylenes; Suspensions; Time Factors; Triazoles | 2010 |
First European long-term experience with the orphan drug rufinamide in childhood-onset refractory epilepsy.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Child; Child, Preschool; Epilepsy; Europe; Female; Humans; Infant; Longitudinal Studies; Male; Middle Aged; Orphan Drug Production; Product Surveillance, Postmarketing; Retrospective Studies; Severity of Illness Index; Treatment Outcome; Triazoles; Young Adult | 2010 |
Experience with rufinamide in a pediatric population: a single center's experience.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Pediatrics; Retrospective Studies; Seizures; Treatment Outcome; Triazoles; Young Adult | 2010 |
Rapid assay of rufinamide in dried blood spots by a new liquid chromatography-tandem mass spectrometric method.
Topics: Anticonvulsants; Blood Specimen Collection; Chemistry Techniques, Analytical; Chemistry, Pharmaceutical; Child, Preschool; Chromatography, High Pressure Liquid; Chromatography, Liquid; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Infant; Male; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Tandem Mass Spectrometry; Triazoles | 2011 |
Rufinamide for the treatment of epileptic spasms.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Follow-Up Studies; Humans; Infant; Male; Retrospective Studies; Spasms, Infantile; Treatment Outcome; Triazoles; Young Adult | 2011 |
Drug-induced QT-interval shortening following antiepileptic treatment with oral rufinamide.
Topics: Administration, Oral; Adult; Aged; Anticonvulsants; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Electrocardiography; Epilepsy; Female; Follow-Up Studies; Humans; Intellectual Disability; Lennox Gastaut Syndrome; Male; Middle Aged; Spasms, Infantile; Triazoles; Young Adult | 2012 |
Dramatic weight loss with rufinamide.
Topics: Adolescent; Adult; Anticonvulsants; Body Mass Index; Epilepsy; Female; Humans; Male; Triazoles; Weight Loss; Young Adult | 2013 |
Rufinamide in children with refractory epilepsy: pharmacokinetics, efficacy, and safety.
Topics: Adolescent; Analysis of Variance; Anticonvulsants; Child; Child, Preschool; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Infant; Male; Retrospective Studies; Triazoles; Valproic Acid | 2012 |
Synthesis and evaluation of pharmacological properties of novel annelated 2,3-benzodiazepine derivatives.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Benzodiazepines; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; In Vitro Techniques; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred DBA; Neurons; Olfactory Pathways; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Structure-Activity Relationship; Triazoles | 2003 |
[Triazole epilepsy].
Topics: Epilepsy; Humans; Triazoles | 1951 |
Neuroprotection by estradiol: a role of aromatase against spine synapse loss after blockade of GABA(A) receptors.
Topics: Animals; Aromatase; Cells, Cultured; Dendritic Spines; Down-Regulation; Enzyme Inhibitors; Epilepsy; Estradiol; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Letrozole; Nerve Degeneration; Neural Inhibition; Neuroprotective Agents; Nitriles; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, GABA-A; Synaptic Transmission; Triazoles | 2007 |
Synthesis of 8-alkoxy-4,5-dihydro-[1,2,4]triazole[4,3-a]quinoline-1-ones and evaluation of their anticonvulsant properties.
Topics: Animals; Anticonvulsants; Convulsants; Electroshock; Epilepsy; Female; Indicators and Reagents; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Pentylenetetrazole; Postural Balance; Quinolones; Spectrophotometry, Infrared; Triazoles | 2006 |
Rufinamide: clinical pharmacokinetics and concentration-response relationships in patients with epilepsy.
Topics: Administration, Oral; Adolescent; Age Factors; Anticonvulsants; Body Mass Index; Child; Child, Preschool; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Female; Food; Half-Life; Humans; Intrinsic Factor; Kidney Diseases; Liver Diseases; Male; Metabolic Clearance Rate; Renal Dialysis; Sex Factors; Syndrome; Triazoles | 2008 |
The anticonvulsant effect of the broad spectrum anticonvulsant loreclezole may be mediated in part by serotonin in rats: a microdialysis study.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Genetic Predisposition to Disease; Hydroxyindoleacetic Acid; Microdialysis; Rats; Rats, Sprague-Dawley; Serotonin; Triazoles | 1994 |
Automated analysis of a novel anti-epileptic compound, CGP 33,101, and its metabolite, CGP 47,292, in body fluids by high-performance liquid chromatography and liquid-solid extraction.
Topics: Anticonvulsants; Autoanalysis; Chromatography, High Pressure Liquid; Epilepsy; Humans; Hydrogen-Ion Concentration; Microchemistry; Quality Control; Sensitivity and Specificity; Solubility; Triazoles | 1995 |
Progress report on new antiepileptic drugs: a summary of the Third Eilat Conference.
Topics: Acetamides; Animals; Anticonvulsants; Azetidines; Carbamates; Drug Evaluation, Preclinical; Drugs, Investigational; Epilepsy; Humans; Israel; Levetiracetam; Nipecotic Acids; Phenylenediamines; Piracetam; Product Surveillance, Postmarketing; Randomized Controlled Trials as Topic; Thiazoles; Tiagabine; Triazoles | 1996 |
Magnesium deficiency-dependent audiogenic seizures (MDDASs) in adult mice: a nutritional model for discriminatory screening of anticonvulsant drugs and original assessment of neuroprotection properties.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Azepines; Brain Chemistry; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Epilepsy; gamma-Aminobutyric Acid; Locomotion; Magnesium Deficiency; Melatonin; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Neuroprotective Agents; Platelet Aggregation Inhibitors; Triazoles | 1998 |
Nefazodone for mood disorder associated with epilepsy.
Topics: Adult; Antidepressive Agents, Second-Generation; Comorbidity; Depressive Disorder; Epilepsy; Humans; Male; Piperazines; Treatment Outcome; Triazoles | 1998 |
The anticonvulsant BW534U87 depresses epileptiform activity in rat hippocampal slices by an adenosine-dependent mechanism and through inhibition of voltage-gated Na+ channels.
Topics: Action Potentials; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Anticonvulsants; Brain Chemistry; CHO Cells; Cricetinae; Electrophysiology; Enzyme Inhibitors; Epilepsy; Female; Hippocampus; In Vitro Techniques; Ion Channel Gating; Magnesium; Male; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sodium Channels; Triazoles | 1999 |
Effects of antiepileptic drugs on cognition.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cognition; Cognition Disorders; Cyclohexanecarboxylic Acids; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Piracetam; Tiagabine; Topiramate; Triazines; Triazoles; Vigabatrin | 2001 |
Anticonvulsant profile of MDL 27,266: an orally active, broad-spectrum anticonvulsant agent.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electric Stimulation; Epilepsy; Female; Male; Mice; Mice, Inbred DBA; Papio; Rats; Rats, Sprague-Dawley; Triazoles | 1992 |
Effects of the triazole derivative loreclezole (R72063) on stimulus induced ionic and field potential responses and on different patterns of epileptiform activity induced by low magnesium in rat entorhinal cortex-hippocampal slices.
Topics: Animals; Anticonvulsants; Calcium; Cerebral Cortex; Epilepsy; Evoked Potentials; Female; Hippocampus; In Vitro Techniques; Magnesium; Rats; Rats, Wistar; Triazoles | 1992 |
In vitro studies on the broad spectrum anticonvulsant loreclezole in the hippocampus.
Topics: Animals; Anticonvulsants; Calcium; Electric Stimulation; Epilepsy; Etomidate; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Magnesium Deficiency; Pentobarbital; Phenobarbital; Triazoles | 1992 |
Influence of CGS 15943 A (a nonxanthine adenosine antagonist) on the protection offered by a variety of antiepileptic drugs against maximal electroshock-induced seizures in mice.
Topics: Adenosine; Animals; Anticonvulsants; Disease Susceptibility; Drug Interactions; Electroshock; Epilepsy; Male; Mice; Motor Activity; Quinazolines; Triazoles | 1991 |
Efficacy and safety evaluation of loreclezole as add-on treatment in therapy-resistant epilepsy patients.
Topics: Adult; Anticonvulsants; Drug Resistance; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged; Triazoles | 1991 |
Single-dose efficacy evaluation of loreclezole in patients with photosensitive epilepsy.
Topics: Adult; Anticonvulsants; Drug Administration Schedule; Epilepsy; Female; Humans; Male; Molecular Structure; Photic Stimulation; Triazoles | 1990 |
CGP 31358 binds to a site on the NMDA receptor that is coupled to both the transmitter recognition site and the channel domain.
Topics: Animals; Anticonvulsants; Binding, Competitive; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Epilepsy; Glutamates; Glutamic Acid; Mice; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Subcellular Fractions; Triazoles | 1989 |