An agonist that binds to and activates farnesoid X receptors
ChEBI ID: 132972
| Member | Definition | Class |
|---|---|---|
| obeticholic acid | A dihydroxy-5beta-cholanic acid that is chenodeoxycholic acid carrying an additional ethyl substituent at the 6alpha-position. A semi-synthetic bile acid which acts as a farnesoid X receptor agonist and is used for treatment of primary biliary cholangitis. | obeticholic acid |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 15 (4.42) | 29.6817 |
| 2010's | 222 (65.49) | 24.3611 |
| 2020's | 102 (30.09) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 27 (7.76%) | 5.53% |
| Reviews | 106 (30.46%) | 6.00% |
| Case Studies | 3 (0.86%) | 4.05% |
| Observational | 2 (0.57%) | 0.25% |
| Other | 210 (60.34%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Alpha-2A adrenergic receptor | Homo sapiens (human) | EC50 | 0.7550 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | EC50 | 0.7550 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | EC50 | 0.7550 | 1 | 1 |
| Bile acid receptor | Homo sapiens (human) | EC50 | 6.2031 | 25 | 25 |
| G-protein coupled bile acid receptor 1 | Homo sapiens (human) | EC50 | 4.7990 | 8 | 8 |
| G-protein coupled bile acid receptor 1 | Mus musculus (house mouse) | EC50 | 5.7400 | 1 | 1 |