Any inhibitor of hepatitis C virus nonstructural protein 5A.
ChEBI ID: 85185
| Member | Definition | Class |
|---|---|---|
| abt-267 | A dipeptide derivative which is used which is in combination with dasabuvir sodium hydrate, paritaprevir and ritonavir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver. | ombitasvir |
| gs-5816 | A complex organic heteropentacyclic compound that is a hepatitis C virus nonstructural protein 5A inhibitor used in combination with sofosbuvir (under the brand name Epclusa) for treatment of patients with chronic hepatitis C of all six major genotypes. | velpatasvir |
| mk-8742 | A complex organic heterotetracyclic compound that is a hepatitis C virus nonstructural protein 5A inhibitor used in combination with grazoprevir (under the brand name Zepatier) for treatment of chronic HCV genotypes 1 or 4 infection in adults. | elbasvir |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 421 (70.88) | 24.3611 |
| 2020's | 173 (29.12) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 158 (24.73%) | 5.53% |
| Reviews | 90 (14.08%) | 6.00% |
| Case Studies | 58 (9.08%) | 4.05% |
| Observational | 35 (5.48%) | 0.25% |
| Other | 298 (46.64%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Genome polyprotein | Hepatitis C virus (isolate Con1) | EC50 | 0.0001 | 8 | 8 |
| Genome polyprotein | Hepatitis C virus JFH-1 | EC50 | 0.0000 | 1 | 1 |
| Nonstructural protein 5A | EC50 | 0.0004 | 48 | 48 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | EC90 | 0.0280 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | EC90 | 0.0280 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | EC90 | 0.0280 | 1 | 1 |
| Genome polyprotein | Hepatitis C virus (isolate Con1) | EC90 | 0.0000 | 1 | 1 |
| Genome polyprotein | Hepatitis C virus (isolate NZL1) | EC90 | 0.0001 | 1 | 1 |
| Nonstructural protein 5A | EC90 | 0.0073 | 25 | 25 | |
| P2X purinoceptor 7 | Homo sapiens (human) | EC90 | 0.0010 | 1 | 1 |