An inhibitor that interferes with the action of MTP.
ChEBI ID: 72298
| Member | Definition | Class |
|---|---|---|
| bms201038 | A member of the class of benzamides obtained by formal condensation of the carboxy group of 4'-(trifluoromethyl)biphenyl-2-carboxylic acid with the primary amino group of 9-[4-(4-aminopiperidin-1-yl)butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide. Used (as its mesylate salt) as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia. | lomitapide |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (6.14) | 29.6817 |
| 2010's | 83 (72.81) | 24.3611 |
| 2020's | 24 (21.05) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 13 (10.16%) | 5.53% |
| Reviews | 52 (40.63%) | 6.00% |
| Case Studies | 15 (11.72%) | 4.05% |
| Observational | 3 (2.34%) | 0.25% |
| Other | 45 (35.16%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 15.0916 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 1.0684 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 1.8999 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 15.0916 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 15.0916 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 15.0916 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 15.0916 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Delta-type opioid receptor | Mus musculus (house mouse) | IC50 | 0.0008 | 1 | 1 |
| Microsomal triglyceride transfer protein large subunit | Homo sapiens (human) | IC50 | 0.0056 | 3 | 3 |