Compounds > 4-amino-5-benzoyl-2-(4-methoxyphenylamino)thiazole
Page last updated: 2024-12-08

4-amino-5-benzoyl-2-(4-methoxyphenylamino)thiazole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4-amino-5-benzoyl-2-(4-methoxyphenylamino)thiazole: upregulates the DR5 receptor; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID398017
CHEMBL ID551857
SCHEMBL ID163591
MeSH IDM0480822

Synonyms (12)

Synonym
nsc707090
NCI60_038082
nsc-707090
CHEMBL551857
[4-amino-2-(4-methoxyanilino)-1,3-thiazol-5-yl]-phenylmethanone
AKOS003597471
4-amino-5-benzoyl-2-(4-methoxyphenylamino)thiazole
SCHEMBL163591
4-amino-5-benzoyl-2-(4-methoxyphenylamino) thiazole
dat1
107401-70-7
4-amino-5-benzoyl-2-(4-methoxy phenyl amino)thiazole
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID427178Antiproliferative activity against human CEM cells after 2 days by coulter counter method2009Journal of medicinal chemistry, Sep-10, Volume: 52, Issue:17
2-Arylamino-4-amino-5-aroylthiazoles. "One-pot" synthesis and biological evaluation of a new class of inhibitors of tubulin polymerization.
AID427179Antiproliferative activity against human HeLa cells after 2 days by coulter counter method2009Journal of medicinal chemistry, Sep-10, Volume: 52, Issue:17
2-Arylamino-4-amino-5-aroylthiazoles. "One-pot" synthesis and biological evaluation of a new class of inhibitors of tubulin polymerization.
AID427176Antiproliferative activity against mouse FM3A cells after 2 days by coulter counter method2009Journal of medicinal chemistry, Sep-10, Volume: 52, Issue:17
2-Arylamino-4-amino-5-aroylthiazoles. "One-pot" synthesis and biological evaluation of a new class of inhibitors of tubulin polymerization.
AID427175Antiproliferative activity against mouse L1210 cells after 2 days by coulter counter method2009Journal of medicinal chemistry, Sep-10, Volume: 52, Issue:17
2-Arylamino-4-amino-5-aroylthiazoles. "One-pot" synthesis and biological evaluation of a new class of inhibitors of tubulin polymerization.
AID427177Antiproliferative activity against human MOLT4 cells after 2 days by coulter counter method2009Journal of medicinal chemistry, Sep-10, Volume: 52, Issue:17
2-Arylamino-4-amino-5-aroylthiazoles. "One-pot" synthesis and biological evaluation of a new class of inhibitors of tubulin polymerization.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (40.00)29.6817
2010's6 (60.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.23

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.23 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.63 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.23)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
2-aminothiazole
2-aminothiazole: RN given refers to parent cpd; structure. 1,3-thiazol-2-amine : A primary amino compound that is 1,3-thiazole substituted by an amino group at position 2.		2.04101,3-thiazoles;
primary amino compound
colchicine
(S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.		2.110alkaloid;
colchicine		anti-inflammatory agent;
gout suppressant;
mutagen
thiazoles
[no description available]		3.67901,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.1110taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		3.3601,2,3-triazole
dendrodoine
dendrodoine: structure given in first source;RN from Chem Abst. Index Guide 1986; from the tunicate Dendrodoa grossularia		2.0610
fosbretabulin
[no description available]		2.0510stilbenoid
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Colon
[description not available]		02.7930
Colonic Neoplasms
Tumors or cancer of the COLON.		02.7930
Angiogenesis, Pathologic
[description not available]		02.0710