Page last updated: 2024-12-06

acetylthiocholine iodide

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Description

Acetylthiocholine iodide is a synthetic compound that serves as a substrate for cholinesterases. It is commonly used in research to study the activity and inhibition of these enzymes. The compound is synthesized through a chemical reaction involving the combination of thiocholine iodide with acetyl chloride. Acetylthiocholine iodide, upon hydrolysis by cholinesterases, yields thiocholine and acetate. Its importance lies in its ability to mimic the action of acetylcholine, a neurotransmitter essential for nerve impulse transmission. By studying the effects of acetylthiocholine iodide on cholinesterases, researchers gain insights into the mechanisms of neurotransmission and the development of drugs that target these enzymes. The compound has been instrumental in the development of anticholinesterase agents used in the treatment of myasthenia gravis and Alzheimer's disease.'

acetylthiocholine iodide: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID74629
SCHEMBL ID400577
MeSH IDM0539131

Synonyms (49)

Synonym
nsc-44139
s-acetylthiocholine iodide
acetylthiocholine diiodide
wln: 1vs2k1&1&1 &i
[(2-mercaptoethyl)trimethylammonium iodide acetate]
ammonium, iodide acetate
acetylthiocholine iodide
nsc44139
1866-15-5
c7h16inos
6skh6p4yrn ,
unii-6skh6p4yrn
ethanaminium, 2-(acetylthio)-n,n,n-trimethyl-, iodide (1:1)
nsc 44139
2-(acetylthio)-n,n,n-trimethylethanaminium iodide
einecs 217-474-1
choline, s-acetylthio-, iodide
ethanaminium, 2-(acetylthio)-n,n,n-trimethyl-, iodide
2-acetylthioethyltrimethylammonium iodide
ammonium, (2-mercaptoethyl)trimethyl-, iodide acetate
((2-mercaptoethyl)trimethylammonium iodide acetate)
s-[2-(trimethyl-.lambda.5-azanyl)ethyl] ethanethioate hydroiodide
s-[2-(trimethyl-.lambda.<5>-azanyl)ethyl] ethanethioate hydroiodide
A-1700
A0116
2-(acetylsulfanyl)-n,n,n-trimethylethanaminium iodide
FT-0600351
AKOS015904269
[2-(acetylsulfanyl)ethyl]trimethylazanium iodide
NTBLZMAMTZXLBP-UHFFFAOYSA-M
SCHEMBL400577
mfcd00011819
CS-D1378
GS-3419
C93437
SY022189
2-(acetylthio)-n,n,n-trimethylethan-1-aminium iodide
A852082
AMY27039
DTXSID50883764
n-(2-(2-chlorobenzoyl)-4-nitrophenyl)-2-iodoacetamide
2-acetylsulfanylethyl(trimethyl)azanium;iodide
?acetylthiocholine iodide
EN300-321574
(2-mercaptoethyl)trimethylammonium iodide, acetate
acetic acid, thio-, s-ester with (2-mercaptoethyl)trimethylammonium iodide
AC-37018
HY-D0904
acetylthiocholine (iodide)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (7.14)29.6817
2010's10 (71.43)24.3611
2020's3 (21.43)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 33.60

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index33.60 (24.57)
Research Supply Index2.83 (2.92)
Research Growth Index5.03 (4.65)
Search Engine Demand Index40.31 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (33.60)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]