triazoles has been researched along with letrozole in 1743 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 76 (4.36) | 18.2507 |
| 2000's | 724 (41.54) | 29.6817 |
| 2010's | 921 (52.84) | 24.3611 |
| 2020's | 22 (1.26) | 2.80 |
| Authors | Studies |
|---|---|
| Borja, J; Pérez, N | 1 |
| Beh, I; Bhatnagar, AS; Müller, P; Schenkel, L; Schieweck, K; Trunet, PF | 1 |
| Bhatnagar, AS; Bowman, R; Häusler, A; Lang, M; Schieweck, K | 1 |
| Brodie, A; Savinov, A; Wang, J; Yue, W | 1 |
| Ashworth, A; Detre, S; Dowsett, M; Lee, K; Macaulay, VM; Nicholls, JE | 1 |
| Baron, J; Cutler, GB; Demers, LM; Klein, KO; Santen, RJ; Santner, SJ | 1 |
| Adlercruetz, H; Brady, C; Demers, LM; Grossberg, H; Harvey, HA; Kambic, KB; Lipton, A; Santen, RJ; Trunet, PF | 1 |
| Bergeron, JM; Crews, D | 1 |
| Demers, LM | 1 |
| Junker Walker, U; Nogués, V | 1 |
| Manni, A | 1 |
| Duval, M; Godbillon, J; Gosset, G; Gygax, D; Marfil, F; Pfister, CU; Sioufi, A; Winkler, B | 1 |
| Batzl, C; Bhatnagar, AS; Häusler, A; Nogués, V | 1 |
| Santen, RJ | 1 |
| Bhatnagar, AS; Dickes, I; Monnet, G; Mueller, P; Trunet, PF; White, G | 1 |
| Ahern, J; Dowsett, M; Iveson, TJ; Smith, IE; Smithers, DA; Trunet, PF | 2 |
| Batzl, C; Bhatnagar, AS; Bowman, R; Furet, P; Häusler, A; Lang, M | 1 |
| Batzl, C; Bhatnagar, AS; Lang, M; Schieweck, K | 1 |
| Brady, C; Demers, LM; Grossberg, H; Harvey, HA; Kambic, KB; Lipton, A; Santen, RJ | 1 |
| Crews, D; Wennstrom, KL | 1 |
| Detre, S; Dowsett, M; Grimshaw, R; Lee, K; Macaulay, VM; Rowlands, M | 1 |
| Dorizzi, M; Pieau, C; Richard-Mercier, N | 1 |
| Desvages, G; Dorizzi, M; Girondot, M; Pieau, C; Richard-Mercier, N | 1 |
| Godbillon, SJ; Marfil, F; Pineau, V; Sioufi, A | 1 |
| Choate, JV; Resko, JA | 1 |
| Detre, S; Dowsett, M; Grimshaw, R; Rowlands, M | 1 |
| Bisagni, G; Cocconi, G; Fraschini, F; Pfister, C; Scaglione, F; Trunet, PF | 1 |
| Bhatnagar, AS; Chaudri, HA; Hornberger, U; Trunet, PF | 1 |
| Camoriano, JK; Gerstner, JB; Gesme, DH; Hartmann, LC; Hatfield, AK; Ingle, JN; Johnson, PA; Loprinzi, CL; Mailliard, JA; Suman, VJ | 1 |
| Czendlik, C; Ezzet, F; Godbillon, J; Howald, H; Pfister, C; Sandrenan, N; Sioufi, A; Trunet, P | 1 |
| Dowsett, M | 3 |
| Spencer, CM; Wiseman, LR | 1 |
| Enomoto, K | 1 |
| Bhatnagar, S; Krishnamurthy, H; Krishnamurthy, HN; Moudgal, RN; Shetty, G | 1 |
| Dixon, JM; Miller, WR; Mullen, P; Sourdaine, P; Telford, J; Watson, C | 1 |
| Buzdar, AU; Roseman, BJ; Singletary, SE | 1 |
| Cardot, JM; Czendlik, C; Gauducheau, N; Godbillon, J; Howald, H; Jaouen, A; Marfil, F; Pfister, C; Pineau, V; Sioufi, A; Vreeland, F | 1 |
| Bellmunt, J; Bezwoda, W; Chaudri, HA; Dombernowsky, P; Falkson, G; Fornasiero, A; Gardin, G; Gudgeon, A; Hatschek, T; Hoffmann, W; Hornberger, U; Leonard, R; Michel, J; Morgan, M; Panasci, L; Smith, I; Tjabbes, T; Trunet, PF | 1 |
| Dickson, RB; El-Ashry, D; Hannum, RS; Kern, FG; Kharbanda, S; Lopez, CA; Lorant, LA; McLeskey, SW; Tobias, CA; Trock, BJ; Zhang, L | 1 |
| Bremmer, WJ; Demers, LM; Kaseta, J; Santen, RJ; Santner, SJ; Sinha, S | 1 |
| Harvey, HA | 2 |
| Brodie, A; Liu, Y; Long, B; Lu, Q; Wang, JP; Yue, W | 1 |
| Smith, IE | 6 |
| Bodrogi, I; Bonaventura, A; Buzzi, F; Campos, D; Chaudri, HA; Friederich, P; Gershanovich, M; Jeffrey, M; Lassus, M; Ludwig, H; Lurie, H; O'Higgins, N; Reichardt, P; Romieu, G | 1 |
| Hoctin-Boes, G; Steinberg, M; Yates, R | 1 |
| Colussi, DM; Lefèvre, GY; Parisot, CY | 1 |
| Brodie, A; Liu, Y; Lu, Q; Wang, J; Yue, W | 1 |
| Norton, A; Smith, IE | 1 |
| Brodie, A; Liu, Y; Long, B; Lu, Q; Wang, J; Yue, W | 1 |
| Dowsett, M; Jacobs, S; Johnston, SR; Jones, A; Smith, IE; Trunet, P | 1 |
| Adkins, JC; Lamb, HM | 1 |
| Brodie, AM; Grigoryev, DN; Long, BJ; Thiantanawat, A; Tilghman, SL; Yue, W | 1 |
| Berstein, LM; Diano, S; Eliza, M; Gutierrez, L; Harada, N; Lysiak, J; Mor, G; Naftolin, F; Santen, RJ; Wang, J; Yue, W | 1 |
| Bershteĭn, LM; Larionov, AA; Poroshina, TE; Zimarina, TS | 1 |
| Hamilton, A; Piccart, M | 1 |
| Dowsett, M; Ingle, JN; Johnson, PA; Jordan, VC; Krook, JE; Loprinzi, CL; Mailliard, JA; Perez, EA; Suman, VJ; Wheeler, RH | 1 |
| Bajetta, E; Bichisao, E; Celio, L; Di Leo, A; Dowsett, M; Guillevin, L; Marchianò, A; Martinetti, A; Pozzi, P; Stani, S; Zilembo, N | 1 |
| Blijham, GH; de Jong, PC | 1 |
| Dowsett, M; Gundacker, H; Houston, SJ; Johnston, SR; Miles, DW; Pfister, C; Sioufi, A; Smith, IE; Verbeek, JA | 1 |
| Bodrogi, I; Bonaventura, A; Buzzi, F; Campos, D; Chaudri, Kh; Friedrich, P; Gershanovich, M; Jeffrey, M; Lassus, M; Ludwig, H; Lurie, H; O'Higgins, NO; Reichard, P; Romieu, G | 1 |
| Bonneterre, J; Feutrie, ML | 1 |
| Chaudri, HA; Trunet, PF | 1 |
| Brodie, A; Gimbel, M; Grigoryev, D; Liu, Y; Long, BJ; Lu, Q | 1 |
| Meester, L; Nuijten, M; Waibel, F; Wait, S | 1 |
| Aberdeen, GW; Albrecht, ED; Pepe, GJ | 2 |
| Brodie, AM; Njar, VC | 1 |
| Miller, WR | 1 |
| Bellamy, C; Cameron, DA; Dixon, JM; Leonard, RC; Love, CD; Miller, WR; Renshaw, L | 1 |
| Coombes, RC; Dowsett, M; Harper-Wynne, C | 1 |
| Dowsett, M; Ingle, JN; Jordan, VC; Suman, VJ | 1 |
| Fowler, K; Gill, K; Kirma, N; Tekmal, RR | 1 |
| Harvey, HA; Santen, RJ | 1 |
| Bajetta, E; Bichisao, E; Pozzi, P; Toffolatti, L; Zilembo, N | 1 |
| Buzdar, AU; Chaudri, HA; Trunet, PF | 1 |
| Cappellini, GC; Casali, A; Casali, M; Giuntini, T; Sega, FM; Terzoli, E | 1 |
| Perey, L | 1 |
| Sonoo, H | 1 |
| Attolico, M; Crucitta, E; De Lena, M; Lorusso, V; Mazzei, A; Sambiasi, D | 1 |
| Dranitsaris, G; Leung, P; Mather, J; Oza, A | 1 |
| Buzdar, A | 1 |
| Cattel, F; Messori, A; Trippoli, S; Vaiani, M | 1 |
| Finkelstein, JB | 1 |
| Casper, RF; Mitwally, MF | 6 |
| Schwetz, BA | 1 |
| Auvray, P; Bichat, F; Genne, P | 1 |
| de Crémoux, P | 1 |
| Kerbrat, P; Lefeuvre, C | 1 |
| Mokbel, K | 2 |
| Albrecht, ED; Babischkin, JS; Burleigh, DW; Mayhew, TM; Pepe, GJ | 1 |
| Apffelstaedt, J; Bapsy, PP; Becquart, D; Boni, C; Chaudri-Ross, HA; Dank, M; Dugan, M; Gershanovich, M; Jänicke, F; Lassus, M; Monnier, A; Mouridsen, H; Pérez-Carrión, R; Pluzanska, A; Salminen, E; Sleeboom, HP; Smith, R; Snyder, R; Staffler, B; Sun, Y; Verbeek, JA | 1 |
| Purohit, A; Reed, MJ | 1 |
| Stanhope, R | 1 |
| Ankarberg-Lindgren, C; Dunkel, L; Norjavaara, E; Sipilä, I; Wickman, S | 1 |
| Brady, C; Buzdar, A; Davidson, N; Douma, J; Elledge, R; Morgan, M; Nabholtz, J; Porter, L; Smith, R; Xiang, X | 1 |
| Tominaga, T | 1 |
| Li, CX; Liu, XD; Xie, L; Zhong, Y | 1 |
| Bairaktari, ET; Elisaf, MS; Kakaidi, B; Katsaraki, A; Nicolaides, C; Pavlidis, NA; Tzallas, CS | 1 |
| Bellamy, CO; Cameron, DA; Dixon, JM; Leonard, RC; Love, CD; Miller, WR; Smith, H | 1 |
| Aghajanian, C; Maluf, FC; Sabbatini, P; Schwartz, L; Xia, J | 1 |
| Hamilton, A; Volm, M | 1 |
| Buzdar, A; Howell, A | 1 |
| Belaid, B; Dorizzi, M; Pieau, C; Richard-Mercier, N | 1 |
| Pritchard, KI | 1 |
| Borgs, M; Brady, C; Coop, A; Dugan, M; Ellis, MJ; Evans, DB; Jänicke, F; Llombert-Cussac, A; Mauriac, L; Miller, WR; Quebe-Fehling, E; Singh, B | 1 |
| Albrecht, ED; Pepe, GJ; Rosenthal, MD | 1 |
| Panasci, LC | 1 |
| Dunkel, L; Wickman, S | 4 |
| Lønning, PE | 2 |
| Cianfarani, S | 1 |
| Murray, R | 1 |
| Joy, AA; Mackey, JR | 1 |
| Cocconi, G | 1 |
| De Braud, F; Duval, M; Hornberger, U; Lelli, G; Martoni, A; Pfister, CU; Souppart, C; Zamagni, C | 1 |
| Heshmati, HM; Khosla, S; Melton, LJ; O'Fallon, WM; Riggs, BL; Robins, SP | 1 |
| Bershteĭn, LM; Gamaiunova, VB; Gershfel'd, ED; Kovalenko, IG; Kovalevskiĭ, AIu; Larionov, AA; Maksimov, SIa; Meshkova, IE; Tsyrlina, EV; Vasil'ev, DA | 1 |
| Nabholtz, JM; Reese, DM | 1 |
| Bando, H; Saji, S; Toi, M | 1 |
| Brink, S | 1 |
| Anker, G; Dowsett, M; Geisler, J; Haynes, B; Lønning, PE | 1 |
| Buzdar, AU | 9 |
| Fenaroli, P; Labianca, R; Tondini, C | 1 |
| Appfelstaedt, J; Borgs, M; Chaudri-Ross, HA; Dugan, M; Eiermann, W; Ellis, M; Eremin, J; Lassus, M; Llombart-Cussac, A; Mauriac, L; Paepke, S; Vinholes, J | 1 |
| Carlini, P; Casali, A; Cognetti, F; De Marco, S; Fabi, A; Frassoldati, A; Nardi, M; Paoloni, F; Papaldo, P; Ruggeri, EM | 1 |
| Hagenäs, L | 1 |
| Kirma, N; Mandava, U; Tekmal, RR | 1 |
| Blankenstein, MA; Blijham, GH; Brodie, AM; Chen, T; DeJong, PC; Elbers, JR; Fulton, A; Long, BJ; Lu, Q; Macpherson, N; Nortier, JW; Schipper, ME; Slee, PH; Thijssen, JH; van de Ven, J; van Gorp, JM | 1 |
| Dixon, JM; Miller, WR | 1 |
| Anderson, TJ; Cameron, DA; Dixon, JM; Miller, WR | 1 |
| Chen, S; Eliza, M; Mor, G; Naftolin, F; Song, J; Wiita, B | 1 |
| Junker, A; Possinger, K; Wiedemann, GJ | 1 |
| Dunkel, L; Saukkonen, T; Wickman, S | 1 |
| Chen, G; Cohen, MH; Johnson, JR; Li, N; Pazdur, R | 1 |
| Timms, B | 1 |
| Buzdar, A; Johnson, PE | 1 |
| Goss, PE | 6 |
| Illiger, HJ | 1 |
| Abe, R; Aoyama, H; Enomoto, K; Nakamura, Y; Nomizu, T; Nomura, Y; Ohashi, Y; Sano, M; Takashima, S; Tohge, T; Tominaga, T | 1 |
| Bajetta, E; Bombardieri, E; Buzzoni, R; Catena, L; Celio, L; Ferrari, L; Gattinoni, L; La Torre, I; Martinetti, A; Pozzi, P; Seregni, E; Vitali, M; Zilembo, N | 1 |
| Ellis, MJ; Shaw, HS | 1 |
| Jones, SE | 1 |
| Benedetto, C; De Nicola, B; Ferraris, F; Genta, F; Piccinno, R; Porpiglia, M; Vicelli, R | 1 |
| Abe, R; Ikeda, S; Koyama, H; Nomizu, T; Nomura, Y; Ohashi, Y; Sano, M; Takashima, S; Tohge, T; Tominaga, T; Ueo, H | 1 |
| Ikeda, S; Kimijima, I; Koyama, H; Nomizu, T; Nomura, Y; Ohashi, Y; Sano, M; Takashima, S; Tohge, T; Tominaga, T; Ueo, H | 1 |
| Alba, E; Colla, F; Farina, C; Mazzoleni, A; Ragonesi, G | 1 |
| Bajetta, E; Bichisao, E; Zilembo, N | 1 |
| Ingle, JN | 4 |
| A'Hern, R; Dowsett, M; Harper-Wynne, C; Iqbal, J; Nasiri, N; Ross, G; Sacks, N; Salter, J | 1 |
| Bulun, SE; Evans, D; Fang, Z; Gurates, B; Simpson, E; Tamura, M; Yang, S | 1 |
| Goss, PE; Smith, RE | 1 |
| Bowman, A; Gabra, H; Langdon, SP; Lessells, A; Smyth, JF; Stewart, M; Young, A | 1 |
| Brodie, AM; Jelovac, D; Long, BJ; Thiantanawat, A | 1 |
| Casper, RF; Fisher, SA; Reid, RL; Van Vugt, DA | 1 |
| Assikis, VJ; Buzdar, A | 1 |
| Berruti, A; Dogliotti, L; Familiari, U; Gorzegno, G; Sperone, P | 1 |
| Albrecht, ED; Billiar, RB; Pepe, GJ; Zachos, NC | 1 |
| Berstein, L; Gamajunova, V; Gershfeld, E; Kovalevskij, A; Larionov, A; Maximov, S; Meshkova, I; Tsyrlina, E; Vasilyev, D | 1 |
| Lammintausta, R; Lehtoranta, M; Poutanen, M; Santti, R; Streng, T; Talo, A | 1 |
| Bettuzzi, S; Filippi, S; Forti, G; Granchi, S; Ledda, F; Luconi, M; Maggi, M; Tozzi, P; Vignozzi, L | 1 |
| George, D; Kantoff, PW; Kaufman, D; Kazanis, M; Manola, J; Oh, WK; Smith, MR | 1 |
| Buzdar, AU; Eiermann, W; Nabholtz, JM; Robertson, JF | 1 |
| Atalay, G; Cardoso, F; Piccart, MJ | 1 |
| Anderson, TJ; Dixon, JM; Miller, WR | 1 |
| Robertson, JF | 1 |
| Adachi, I; Ikeda, T; Ohashi, Y; Sasaki, Y; Suwa, T; Tabei, T; Takatsuka, Y; Toi, M; Tominaga, T | 1 |
| Albrecht, ED; Ballard, PL; Pepe, GJ | 1 |
| Kalofonos, HP; Karamanos, NK; Kletsas, D; Mitropoulou, TN; Tzanakakis, GN | 1 |
| Crescioli, C; Ferruzzi, P; Forti, G; Granchi, S; Luconi, M; Maggi, M; Mancina, R; Muratori, M; Serio, M; Vannelli, GB | 1 |
| Martín de Vidales, C; Pérez-Torrubia, A; Zapatero, A | 1 |
| Jones, T; Karnon, J | 1 |
| Bryan, TM; Carpenter, KD; Gray, CA; Spencer, TE; Welsh, TH | 1 |
| Ali, SM; Brady, C; Carney, W; Chaudri-Ross, HA; Demers, L; Harvey, HA; Leitzel, K; Lipton, A; Wyld, P | 1 |
| Anderson, TJ; Cameron, D; Dixon, JM; Macfarlane, L; Miller, WR | 1 |
| Apffelstaedt, J; Bapsy, PP; Becquart, D; Bhatnagar, A; Boni, C; Chaudri-Ross, H; Dank, M; Gershanovich, M; Jaenicke, F; Lang, R; Monnier, A; Mouridsen, H; Perez-Carrion, R; Pluzanska, A; Salminen, E; Sleeboom, HP; Smith, R; Snyder, R; Sun, Y; Wyld, P | 1 |
| Berstein, LM; Harada, H; Lykkesfeldt, AE; Naftolin, F; Santen, RJ; Shanabrough, M; Wang, JP; Yue, W; Zheng, H | 1 |
| Dranitsaris, G; Trudeau, M; Verma, S | 1 |
| Burton, G; Kleeberg, U; Mauriac, L; Osborne, CK; Robertson, JF; Vergote, I | 1 |
| Artac, M; Bozcuk, HS; Ozdogan, M; Sagtas, E; Samur, M; Savas, B; Yildiz, M | 1 |
| Höffken, K; Sayer, HG | 1 |
| de Ziegler, D | 1 |
| Baum, M; Buzdar, A | 1 |
| Rocchi, A; Verma, S | 1 |
| Bhatnager, A; Geisler, J; Lønning, PE | 1 |
| Rose, C | 2 |
| Brodie, AH; Mouridsen, HT | 1 |
| Dowsett, M; Ellis, MJ | 1 |
| Thomas, R | 1 |
| Dixon, JM; Jackson, J; Miller, WR | 1 |
| Dunkel, L; Kajantie, E; Wickman, S | 1 |
| Eckhardt, S | 1 |
| Lønning, P; Martoni, A; Pfister, C; Zamagni, C | 1 |
| Gershanovich, M; Mouridsen, H | 1 |
| Mudur, G | 1 |
| Bryant, J; Wolmark, N | 1 |
| Burstein, HJ | 1 |
| Abrams, JS; Castiglione, M; Davidson, NE; Goss, PE; Ingle, JN; Livingston, RB; Martino, S; Muss, HB; Norton, L; Palmer, MJ; Pater, JL; Perez, EA; Piccart, MJ; Pritchard, KI; Robert, NJ; Shepherd, LE; Therasse, P; Tu, D | 1 |
| Sharma, DC | 1 |
| Ben Ayed, F; Burdette-Radoux, S; Caicedo, JJ; Chaudri-Ross, HA; Davidson, N; Gershanovich, M; Gervasio, H; Johnson, S; Lang, R; Manikhas, G; Pluzanska, A; Rose, C; Thomas, R; Vtoraya, O | 1 |
| Chaudri-Ross, HA; Coop, A; Ellis, MJ; Evans, DB; Jänicke, F; Llombart-Cussac, A; Mauriac, L; Miller, WR; Quebe-Fehling, E; Singh, B; Tao, Y | 1 |
| Connell, BJ; Cribb, AE; McQuaid, T; Saleh, TM | 1 |
| Glendenning, A; Johnston, SR; Jones, T; Karnon, J | 1 |
| Carlini, P; Cognetti, F; Di Cosimo, S; Fabi, A; Ferretti, G; Milella, M; Papaldo, P; Ruggeri, EM | 1 |
| Hobson, K | 1 |
| Alanen, K; Grénman, S; Hietanen, S; Klemi, P; Salmi, T; Varpula, M | 1 |
| Ahmad, K | 1 |
| Brodie, AH; Jelovac, D; Long, B | 1 |
| Dixon, JM; Jackson, J; Miller, WR; Renshaw, L | 1 |
| Dressman, H; Ellis, MJ; Marks, J; Rosen, E | 1 |
| Chow, LW; Toi, M; Wong, JL | 1 |
| Jones, J; Kirma, N; Luthra, R; Tekmal, RR | 1 |
| Bhatnagar, AS; Dixon, JM; Dowsett, M; Haynes, BP; Miller, WR | 1 |
| Hajszan, T; Leranth, C; MacLusky, NJ | 2 |
| Twombly, R | 1 |
| Brodie, AH; Mouridsen, HT; Rose, C; Smith, IE | 1 |
| Biljan, MM; Healey, S; Tan, SL; Tulandi, T | 1 |
| Altaner, S; Kilic-Okman, T; Kucuk, M | 1 |
| Casper, RF | 3 |
| Garfield, RE; Given, RL; Shi, L; Shi, SQ; von Hertzen, H | 1 |
| Runowicz, CD | 1 |
| Camus, M; Devroey, P; Fatemi, HM; Kolibianakis, E; Tournaye, H; Van Steirteghem, AC | 1 |
| Filippi, S; Forti, G; Gelmini, S; Granchi, S; Ledda, F; Luconi, M; Maggi, M; Mancina, R; Marini, M; Morelli, A; Orlando, C; Vannelli, GB; Vignozzi, L | 1 |
| DeGrendele, H | 1 |
| Cobellis, L; De Simone, S; Fava, A; Petraglia, F; Razzi, S; Sartini, A | 1 |
| Ailawadi, RK; Bulun, SE; Gurates, B; Jobanputra, S; Kataria, M | 1 |
| Hietanen, P; Mäkelä, M | 1 |
| Shahab, N | 1 |
| Harris, SR | 1 |
| Hellman, D; Hellman, S | 1 |
| Domont, J; Khayat, D; Namer, M; Spano, JP | 1 |
| Kawakami, M; Saji, S; Toi, M | 1 |
| Dunkel, L; Jänne, OA; Raivio, T; Wickman, S | 1 |
| Ellis, MJ | 1 |
| Dixon, JM | 2 |
| Brodie, AM; Goloubeva, OG; Handratta, V; Jelovac, D; Long, BJ; MacPherson, N; Ragaz, J; Thiantanawat, A | 1 |
| Campos, SM | 1 |
| Ferrero, JM; Foa, C; Hartmann, MT; Italiano, A; Largillier, R; Marcy, PY; Namer, M | 1 |
| Armeanu, S; Fersis, N; Friedrich, M; Gagulic, E; Pantic, L; Relakis, K; Smyczek-Gargya, B; Wallwiener, D | 1 |
| Altundag, K; Oyan, B; Ozisik, Y | 1 |
| Arora, A; Potter, JF | 1 |
| Tiboni, GM | 1 |
| Chaudri-Ross, HA; Mouridsen, HT | 1 |
| Harden, C; MacLusky, NJ | 1 |
| Dimopoulos, MA; Efstathiou, E; Grimani, I; Hamilos, G; Markaki, S; Papadimitriou, CA; Siapkaras, J; Vlachos, G; Zorzou, M | 1 |
| Al-Hadithi, N; Al-Omari, WR; Sulaiman, WR | 1 |
| Clemons, M; Coleman, RE; Verma, S | 1 |
| Sainsbury, R | 1 |
| Curran, MP; Perry, CM; Simpson, D | 1 |
| Ellis, M | 1 |
| Aglietta, M; Cirillo, S; Gatti, M; Martincich, L; Montemurro, F; Regge, D; Russo, F | 1 |
| Hori, H; Kagawa, N; Waterman, MR; Yoshioka, S | 1 |
| Gerken, P | 1 |
| Aberdeen, GW; Albrecht, ED; Pepe, GJ; Reynolds, MA; Sauk, JJ | 1 |
| Chakravarty, BN; Chattopadhyay, R; Chaudhury, K; Das, T; Goswami, SK; Kabir, SN; Kumar, J; Sawhney, V | 1 |
| Ben Ari, T; Ben Eliezer, M; Eshet, R; Gat-Yablonski, G; Maor, G; Phillip, M | 1 |
| Brauckmann, S; Fester, L; Frotscher, M; Jarry, H; Kretz, O; Naumann, T; Prange-Kiel, J; Rune, GM; Wehrenberg, U; Zhao, S; Zhou, L | 1 |
| Aebi, S; Baumann, ChK | 1 |
| Fleck, F | 1 |
| Chow, LW; Guan, XY; Loo, WT; Toi, M; Zhu, L | 1 |
| Howell, A; Tobias, JS | 1 |
| Tobias, JS | 1 |
| Barrett, JC; Berrigan, D; Brodie, A; Hursting, SD; Jelovac, D; Macedo, L; Núñez, NP; Perkins, SN | 1 |
| Cheung, AM; Goss, PE; Hu, H; Mendes, M; Pritzker, KP; Qi, S | 1 |
| Altundag, K; Buzdar, AU; Hortobagyi, G; Morandi, P; Rouzier, R; Theriault, RL | 1 |
| Capel, B; DiNapoli, L; Yao, HH | 1 |
| Abou-Jawde, RM; Alemany, CA; Budd, GT; Choueiri, TK | 1 |
| Becquart, D; Chaudri-Ross, HA; Gershanovich, M; Lang, R; Mouridsen, H; Perez-Carrion, R; Sun, Y | 1 |
| Chaudri-Ross, HA; Mouridsen, H | 1 |
| Reddy, DS | 1 |
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| Amy, JJ; Bourgain, C; Breugelmans, M; De Sutter, P; Leunen, M | 1 |
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| Browne, P; Conley, AJ; Corbin, CJ; Glickman, SE; Hughes, AL; Mapes, SM; Place, NJ | 1 |
| Castiglione-Gertsch, M; Chirgwin, J; Coates, AS; Colleoni, M; Del Mastro, L; Forbes, JF; Gelber, RD; Goldhirsch, A; Jakobsen, EH; Keshaviah, A; Láng, I; Mauriac, L; Mouridsen, H; Nogaret, JM; Paridaens, R; Pienkowski, T; Price, KN; Smith, I; Thürlimann, B; Wardley, A | 1 |
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| At-Taras, EE; Berger, T; Conley, A; Kim, IC; Roser, JF | 1 |
| Castiglione-Gertsch, M; Coates, AS; Debled, M; Forbes, JF; Gelber, RD; Goldhirsch, A; Keshaviah, A; Láng, I; Mauriac, L; Monnier, A; Mouridsen, H; Nogaret, JM; Paridaens, R; Price, KN; Rabaglio, M; Smith, I; Thürlimann, B; Viale, G; Wardley, A; Zabaznyi, N | 1 |
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| Delgado, A; Gonzales, GF; Gonzales-Castañeda, C; Noriega-Hoces, L; Noriega-Portella, L; Rubio, J | 1 |
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| Chaudri Ross, HA; Ellis, MJ; Evans, DB; Miki, Y; Miller, WR; Sasano, H; Suzuki, T; Tao, Y | 1 |
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| Braye, SG; Castiglione-Gertsch, M; Coates, AS; Dell'Orto, P; Gelber, RD; Giobbie-Hurder, A; Goldhirsch, A; Gusterson, BA; Knox, F; MacGrogan, G; Maiorano, E; Mastropasqua, MG; Neven, P; Ohlschlegel, C; Olszewski, WP; Orosz, Z; Price, KN; Regan, MM; Thürlimann, B; Viale, G | 1 |
| Dos Reis, FJ; Ferriani, RA; Filho, FM; Martins, WP; Nastri, CO | 1 |
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| Doherty, M; Hopkins, JJ; Jang, RW; Warner, E | 1 |
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| Alberts, DS; Bartels, HG; Bartels, PH; Fabian, CJ; Frank, DH; Kimler, BF; Ranger-Moore, J; Yozwiak, M | 1 |
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| Bütow, A; Fester, L; Huber, C; Jarry, H; Prange-Kiel, J; Rune, GM; von Lossow, R; Zhou, L | 1 |
| Abbate, S; Castiglioni, E; Lebon, F; Longhi, G; Potter, BV; Woo, LW; Wood, PM | 1 |
| Al Mufti, R; Behranwala, K; Hadjiminas, DJ; Lanitis, S; Sivakumar, S; Zacharakis, E | 1 |
| Ejlertsen, B; Henriksen, KL; Lykkesfeldt, AE; Mouridsen, HT; Møller, S; Rasmussen, BB | 1 |
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| Contento Salcedo, AM; Muñoz Fernández, L; Rodríguez-Flores, J | 1 |
| Bagnardi, V; Balduzzi, A; Bertolini, F; Cardillo, A; Colleoni, M; Goldhirsch, A; Mancuso, P; Montagna, E; Orlando, L; Scarano, E; Torrisi, R; Veronesi, P; Viale, G | 1 |
| Aguggini, S; Allevi, G; Banham, AH; Bates, G; Berruti, A; Bersiga, A; Bonardi, S; Bottini, A; Brizzi, MP; Campo, L; Dogliotti, L; Fox, SB; Generali, D; Harris, AL; Milani, M | 1 |
| Brodie, A; Goloubeva, O; Macedo, L; Sabnis, G; Schayowitz, A | 1 |
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| Alberts, S; Dentchev, T; Hines, SL; Johnson, DB; Kahanic, S; Liu, H; Loprinzi, CL; Mazurczak, MA; Mincey, B; Nikcevich, DA; Perez, EA; Schaefer, PL; Sloan, JA | 1 |
| Biegon, A; Ding, YS; Ferrieri, RA; Fischer, A; Fowler, JS; Kil, KE; Kim, SW; Pareto, D; Schueller, MJ | 1 |
| Anderson, TJ; Dixon, JM; Evans, DB; Krause, A; Larionov, A; Miller, WR; Renshaw, L; Sing, T; Walker, JR | 1 |
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| Campbell, I; Colleoni, M; Gelber, RD; Goldhirsch, A; Price, KN; Ravaioli, A; Simoncini, E; Sun, Z; Towler, M | 1 |
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| Berger, T; Conley, AJ; Corbin, CJ; Ford, JJ; Harada, N; Roselli, CE; Roser, JF; Sienkiewicz, W; Trainor, BC; Vidal, JD | 1 |
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| Campone, M; Castiglione-Gertsch, M; Coates, AS; Colleoni, M; Forbes, JF; Gelber, RD; Goldhirsch, A; Hawle, H; Láng, I; Mouridsen, H; Nogaret, JM; Paridaens, RJ; Pienkowski, T; Price, KN; Rabaglio, M; Smith, I; Sun, Z; Thürlimann, B | 1 |
| Bae, K; Budd, GT; Carey, LA; Commean, P; Ellis, MJ; Esserman, LJ; Fleming, GF; Giuntoli, T; Harris, LA; Leight, GS; Luo, J; Marcom, PK; Olson, JA | 1 |
| Ata, B; Tulandi, T | 1 |
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| Kolasa-Wołosiuk, A; Leszczyński, B; Marchlewicz, M; Misiakiewicz-Has, K; Pilutin, A; Trybek, G; Urban, F; Wiszniewska, B; Wróbel, A | 1 |
| Bonnefoi, H; Castiglione, M; Coates, AS; Colleoni, M; Ejlertsen, B; Gelber, RD; Giobbie-Hurder, A; Goldhirsch, A; Harvey, VJ; Láng, I; Maibach, R; Neven, P; Rabaglio, M; Regan, MM; Ruepp, B; Sun, Z; Thürlimann, B; Wardley, A | 1 |
| Abdi, E; Aebi, S; Burstein, HJ; Chirgwin, J; Coates, AS; Colleoni, M; Courtois, A; Farah, S; Gavilá, J; Gelber, RD; Goldhirsch, A; Gombos, A; Graas, MP; Hitre, E; Jerusalem, G; Kamby, C; Karlsson, P; Kuroi, K; Loi, S; Loibl, S; Marth, C; Müller, B; Neven, P; O'Reilly, S; Rabaglio, M; Regan, MM; Ribi, K; Ruepp, B; Ruhstaller, T; Simoncini, E; Thompson, A; Viale, G | 1 |
| Asgharnia, M; Hosseini, A; Hosseinzadeh, E; Mehrafza, M; Raoufi, A; Samadnia, S; Tamimi, A; Zahiri, Z; Zare Yousefi, T | 1 |
| Boué, SM; Burow, ME; Davidson, AM; Gupta, A; Khupse, R; Patel, JR; Payton-Stewart, F; Tilghman, SL; Walker, RR; Williams, CC | 1 |
| Aberdeen, GW; Albrecht, ED; Babischkin, JS; Baranyk, IA; Lynch, TJ; Pepe, GJ; Prior, SJ | 1 |
| Aguiar, LPT; Coelho, SS; Del Puerto, HL; Ferreira, MCF; Moraes, LM; Oliveira, GG; Oliveira, RM; Prazeres, PHDM; Silveira, CO; Souza, FHS | 1 |
| De Luca, M; Garofalo, A; Grande, F; Ioele, G; Occhiuzzi, MA; Ragno, G; Rizzuti, B | 1 |
| Albrecht, ED; Kim, SO; Pepe, GJ | 1 |
| Andersson, M; Buch-Larsen, K; Gillberg, L; Marina, D; Rasmussen, ÅK; Schwarz, P | 1 |
| Chakraborty, R; Dey, A; Gopalakrishnan, AV; K K, V; Mukherjee, AG; Nagarajan, D; P, JP; Renu, K; T, TP; V, A; Vellingiri, B; Wanjari, UR | 1 |
| Babbitt, C; Edwards, M; Lacreuse, A; Lam, S; Pereira, M; Ranjan, R | 1 |
| Chen, Y; Gao, M; Jin, X; Shi, L; Ye, S; Zhang, Z | 1 |
| Berger, T; Kang, S | 1 |
| Akgul, OK; Guraslan, H | 1 |
| Banjara, B; Boué, SM; Burow, ME; Davidson, AM; Ohemeng, A; Patel, JR; Tilghman, SL | 1 |
| Babayev, SN; Baumgarten, SC; Neblett, MF; Shenoy, CC | 1 |
| Bandos, H; Brufsky, AM; Chia, SK; Dakhil, SR; Fehrenbacher, L; Geyer, CE; Jeong, JH; Lembersky, BC; Mamounas, EP; McCarron, EC; Rastogi, P; Soori, GS; Swain, SM; Wade, JL; Walshe, JM; Wolmark, N | 1 |
| Albasanz, JL; Diaz de Greñu, B; Durá, G; Fernández-Aroca, DM; Jalón, FA; Manzano, BR; Organero, JA; Rodríguez, AM; Ruiz-Hidalgo, MJ; Sánchez-Prieto, R; Santos, L | 1 |
| Al-Thuwaynee, S; Swadi, AAJ | 1 |
| Krisnadi, SR; Nugrahani, AD; Rachmawati, A; Santoso, SA | 1 |
290 review(s) available for triazoles and letrozole
| Article | Year |
|---|---|
Aromatase inhibitors: clinical pharmacology and therapeutic implications in breast cancer.
Topics: Aminoglutethimide; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Fadrozole; Female; Humans; Imidazoles; Letrozole; Nitriles; Triazoles | 1992 |
Highly selective inhibition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aromatase Inhibitors; Estrogen Antagonists; Estrogens; Fadrozole; Imidazoles; Letrozole; Mammary Neoplasms, Experimental; Nitriles; Steroids; Triazoles | 1990 |
Clinical use of aromatase inhibitors in the treatment of breast cancers.
Topics: Aminoglutethimide; Animals; Aromatase Inhibitors; Breast Neoplasms; Fadrozole; Female; Humans; Letrozole; Nitriles; Rats; Triazoles | 1993 |
The control and biological importance of intratumoural aromatase in breast cancer.
Topics: Adenocarcinoma; Androgens; Androstenedione; Animals; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Carcinoma; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Estrogens; Female; Humans; Letrozole; Male; Mice; Neoplasm Proteins; Neoplasm Recurrence, Local; Neoplasm Transplantation; Neoplasms, Hormone-Dependent; Nitriles; Triazoles; Tumor Cells, Cultured | 1996 |
Letrozole (CGS 20267), a new oral aromatase inhibitor for the treatment of advanced breast cancer in postmenopausal patients.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Estrogens; Evaluation Studies as Topic; Female; Humans; Letrozole; Male; Nitriles; Postmenopause; Triazoles | 1996 |
New aromatase inhibitors for breast cancer.
Topics: Anastrozole; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Randomized Controlled Trials as Topic; Triazoles | 1997 |
Vorozole.
Topics: Anastrozole; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Triazoles | 1997 |
[New drugs in metastatic breast cancer--1997].
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Aromatase Inhibitors; Breast Neoplasms; Bridged-Ring Compounds; Camptothecin; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cyclophosphamide; Diphosphonates; Drug Resistance, Multiple; Female; Humans; Ibandronic Acid; Imidazoles; Letrozole; Nitriles; Tamoxifen; Taxoids; Triazoles; Zoledronic Acid | 1997 |
Use of aromatase inhibitors in postmenopausal women with advanced breast cancer.
Topics: Aminoglutethimide; Anastrozole; Androstenedione; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Estrogen Antagonists; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Tamoxifen; Triazoles | 1997 |
Emerging role of aromatase inhibitors in the treatment of breast cancer.
Topics: Aged; Aminoglutethimide; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Estrogens; Female; Humans; Letrozole; Megestrol Acetate; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Randomized Controlled Trials as Topic; Triazoles | 1998 |
Pivotal trials of letrozole: a new aromatase inhibitor.
Topics: Aminoglutethimide; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Disease-Free Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Letrozole; Megestrol Acetate; Nitriles; Treatment Outcome; Triazoles | 1998 |
Theoretical considerations for the ideal aromatase inhibitor.
Topics: Aminoglutethimide; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase III as Topic; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Triazoles | 1998 |
Fadrozole and letrozole in advanced breast cancer: clinical and biochemical effects.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Fadrozole; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Randomized Controlled Trials as Topic; Triazoles | 1998 |
Letrozole. A review of its use in postmenopausal women with advanced breast cancer.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Area Under Curve; Aromatase Inhibitors; Biological Availability; Breast Neoplasms; Female; Humans; Intestinal Absorption; Letrozole; Nitriles; Postmenopause; Survival Rate; Triazoles | 1998 |
The third-generation non-steroidal aromatase inhibitors: a review of their clinical benefits in the second-line hormonal treatment of advanced breast cancer.
Topics: Aged; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Belgium; Breast Neoplasms; Clinical Trials as Topic; Disease Progression; Female; Humans; Letrozole; Middle Aged; Neoplasm Metastasis; Nitriles; Postmenopause; Severity of Illness Index; Survival Rate; Tamoxifen; Treatment Outcome; Triazoles | 1999 |
New aromatase inhibitors for the treatment of advanced breast cancer in postmenopausal women.
Topics: Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Female; Humans; Letrozole; Megestrol Acetate; Nitriles; Postmenopause; Triazoles | 1999 |
[Aromatase inhibitors].
Topics: Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Estrogen Antagonists; Estrone; Female; Humans; Letrozole; Nitriles; Triazoles | 1999 |
Aromatase inhibitors and their application in breast cancer treatment*.
Topics: Androstenedione; Animals; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Estrogens; Female; Humans; Letrozole; Mice; Nitriles; Tamoxifen; Triazoles | 2000 |
Drug and hormone interactions of aromatase inhibitors.
Topics: Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Drug Interactions; Enzyme Inhibitors; Estrogens; Fadrozole; Female; Humans; Letrozole; Male; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Premenopause; Sensitivity and Specificity; Tamoxifen; Triazoles | 1999 |
Lessons from the use of aromatase inhibitors in the neoadjuvant setting.
Topics: Aged; Anastrozole; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Enzyme Inhibitors; Estrogen Antagonists; Female; Humans; Letrozole; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Receptors, Estrogen; Tamoxifen; Triazoles | 1999 |
Aromatase inhibitors: a dose-response effect?
Topics: Aminoglutethimide; Anastrozole; Animals; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrogens; Fadrozole; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Triazoles | 1999 |
Aromatase inhibitors and their use in the sequential setting.
Topics: Androstenedione; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Triazoles | 1999 |
Combination hormonal therapy involving aromatase inhibitors in the management of women with breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Estrogen Antagonists; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles | 1999 |
Use of aromatase inhibitors in breast carcinoma.
Topics: Adult; Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Drug Design; Drug Interactions; Drug Resistance, Neoplasm; Enzyme Inhibitors; Estrogens; Female; Humans; Letrozole; Middle Aged; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Premenopause; Tamoxifen; Triazoles | 1999 |
Steroidal aromatase inhibitors in elderly patients.
Topics: Aged; Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Triazoles | 2000 |
[Aromatase inhibitors for treatment of advanced breast cancers].
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Estrogen Antagonists; Fadrozole; Female; Humans; Letrozole; Nitriles; Treatment Outcome; Triazoles | 2000 |
New aromatase inhibitors in the treatment of advanced breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Double-Blind Method; Enzyme Inhibitors; Estrogens; Female; Humans; Letrozole; Multicenter Studies as Topic; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Triazoles | 2000 |
Survival in patients with metastatic breast cancer: analysis of randomized studies comparing oral aromatase inhibitors versus megestrol.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Megestrol; Neoplasm Metastasis; Nitriles; Proportional Hazards Models; Randomized Controlled Trials as Topic; Survival Analysis; Triazoles | 2000 |
[Preclinical evaluation of aromatase inhibitors antitumor activity].
Topics: Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Animals; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fadrozole; Female; Humans; Letrozole; Models, Animal; Nitriles; Rats; Structure-Activity Relationship; Triazoles | 2000 |
[Aromatase inhibitors: pharmacological aspects].
Topics: Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Enzyme Inhibitors; Fadrozole; Female; Humans; Letrozole; Nitriles; Triazoles | 2000 |
[Aromatase inhibitors: a review of clinical trials].
Topics: Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Randomized Controlled Trials as Topic; Triazoles | 2000 |
Aromatase regulation and breast cancer.
Topics: 2-Methoxyestradiol; Adult; Animals; Aromatase; Aromatase Inhibitors; Aryl Hydrocarbon Hydroxylases; Breast; Breast Neoplasms; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Cytokines; Dietary Fats; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Estradiol; Estrogens; Female; Fibroblasts; Humans; Letrozole; Middle Aged; Nitriles; Obesity; Pesticides; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Triazoles | 2001 |
[Developments of hormonal agents for breast cancer].
Topics: Adult; Aged; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Humans; Letrozole; Middle Aged; Nitriles; Tamoxifen; Triazoles | 2001 |
Nonsteroidal and steroidal aromatase inhibitors in breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Enzyme Inhibitors; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Triazoles | 2001 |
Advances in aromatase inhibition: clinical efficacy and tolerability in the treatment of breast cancer.
Topics: Anastrozole; Androstadienes; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Fadrozole; Female; Headache; Humans; Letrozole; Nausea; Nitriles; Treatment Outcome; Triazoles; Vomiting | 2001 |
Role of anti-aromatase agents in postmenopausal advanced breast cancer.
Topics: Aged; Anastrozole; Androstadienes; Antineoplastic Agents, Phytogenic; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Receptors, Estrogen; Tamoxifen; Triazoles | 2001 |
Third-generation aromatase inhibitors in the treatment of advanced breast cancer.
Topics: Adult; Aged; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Letrozole; Mastectomy; Middle Aged; Neoplasm Staging; Nitriles; Randomized Controlled Trials as Topic; Tamoxifen; Treatment Outcome; Triazoles | 2001 |
Aromatase and aromatase inhibitors.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase III as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Female; Follow-Up Studies; Humans; Letrozole; Nitriles; Survival Analysis; Treatment Outcome; Triazoles | 2001 |
A summary of second-line randomized studies of aromatase inhibitors.
Topics: Aminoglutethimide; Anastrozole; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Drug Tolerance; Enzyme Inhibitors; Estrogen Receptor Modulators; Fadrozole; Female; Humans; Letrozole; Megestrol Acetate; Neoplasms, Hormone-Dependent; Nitriles; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles | 2001 |
Are differences in the available aromatase inhibitors and inactivators significant?
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Triazoles | 2001 |
Preliminary data from ongoing adjuvant aromatase inhibitor trials.
Topics: Anastrozole; Androstadienes; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Estrogen Antagonists; Female; Humans; Letrozole; Neoadjuvant Therapy; Neoplasms, Hormone-Dependent; Nitriles; Tamoxifen; Triazoles | 2001 |
Letrozole in the treatment of breast cancer.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Biological Availability; Breast Neoplasms; Clinical Trials as Topic; Costs and Cost Analysis; Enzyme Inhibitors; Female; Humans; Letrozole; Metabolic Clearance Rate; Nitriles; Postmenopause; Triazoles | 2002 |
Antiaromatase agents: evolving role in adjuvant therapy.
Topics: Anastrozole; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles | 2002 |
[The role of aromatase inhibitors in the treatment of breast neoplasms. An evaluation of clinical efficacy and the tolerability profile].
Topics: Adult; Aminoglutethimide; Anastrozole; Androstadienes; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Enzyme Inhibitors; Female; Follow-Up Studies; Forecasting; Humans; Letrozole; Middle Aged; Nitriles; Randomized Controlled Trials as Topic; Selective Estrogen Receptor Modulators; Tamoxifen; Time Factors; Triazoles | 2002 |
[Antiestrogen therapy in the treatment of breast neoplasms].
Topics: Adult; Anastrozole; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Enzyme Inhibitors; Estrogen Antagonists; Female; Forecasting; Humans; Indoles; Letrozole; Middle Aged; Neoplasm Metastasis; Nitriles; Osteoporosis; Postmenopause; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Tamoxifen; Toremifene; Triazoles | 2002 |
Letrozole for the management of breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Drug Tolerance; Estrogen Receptor Modulators; Estrogens; Female; Humans; Letrozole; Neoadjuvant Therapy; Nitriles; Postmenopause; Progestins; Receptors, Estrogen; Treatment Outcome; Triazoles | 2002 |
Recent advances in aromatase inhibitor therapy for breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Premenopause; Triazoles | 2002 |
New generation aromatase inhibitors--from the advanced to the adjuvant setting.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Triazoles | 2002 |
The evolving role of aromatase inhibitors in breast cancer.
Topics: Anastrozole; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Humans; Letrozole; Nitriles; Triazoles | 2002 |
An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, letrozole, and exemestane.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Triazoles | 2002 |
Anti-tumor effects of letrozole.
Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Enzyme Inhibitors; Estrogen Receptor Modulators; Estrogens; Female; Humans; Letrozole; Mastectomy, Segmental; Neoadjuvant Therapy; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Salvage Therapy; Tamoxifen; Treatment Outcome; Triazoles | 2002 |
Pharmacology and pharmacokinetics of the newer generation aromatase inhibitors.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Female; Humans; Letrozole; Lipids; Nitriles; Postmenopause; Triazoles | 2003 |
[Present and future of adjuvant hormone therapy in breast cancer: clinical evidence and clinical trials].
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Female; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles | 2003 |
The dawning of the non-cancer uses of aromatase inhibitors in gynaecology.
Topics: Aromatase Inhibitors; Drug Approval; Enzyme Inhibitors; Female; Fertility Agents, Female; Follicle Stimulating Hormone, Human; Gonadotropin-Releasing Hormone; Gynecology; Humans; Letrozole; Luteinizing Hormone; Nitriles; Oocytes; Ovulation Induction; Pregnancy; Triazoles | 2003 |
The current status of aromatase inhibitors in the management of breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Triazoles | 2003 |
Development of aromatase inhibitors and their pharmacologic profile.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Estrogen Antagonists; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Triazoles | 2003 |
A comparison of the efficacy of aromatase inhibitors in second-line treatment of metastatic breast cancer.
Topics: Aminoglutethimide; Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Female; Humans; Letrozole; Megestrol Acetate; Neoplasm Metastasis; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Receptors, Estrogen; Tamoxifen; Triazoles | 2003 |
Applicability of the intratumor aromatase preclinical model to predict clinical trial results with endocrine therapy.
Topics: Anastrozole; Androstadienes; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Estrogen Antagonists; Humans; Letrozole; Neoplasm Metastasis; Nitriles; Tamoxifen; Triazoles; Xenograft Model Antitumor Assays | 2003 |
Emerging role of aromatase inhibitors in the adjuvant setting.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Bone Remodeling; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Enzyme Inhibitors; Humans; Letrozole; Neoadjuvant Therapy; Nitriles; Quality of Life; Tamoxifen; Triazoles | 2003 |
Safety issues surrounding the use of aromatase inhibitors in breast cancer.
Topics: Anastrozole; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Female; Humans; Letrozole; Metabolism; Nitriles; Patient Satisfaction; Quality of Life; Safety; Tamoxifen; Triazoles | 2003 |
Should aromatase inhibitors replace tamoxifen?
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles | 2003 |
[Perspectives for the hormonal therapy of breast cancer].
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Breast Neoplasms; Enzyme Inhibitors; Estradiol; Estrogen Receptor Modulators; Female; Fulvestrant; Humans; Letrozole; Nitriles; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Toremifene; Triazoles | 2003 |
Pharmacokinetics of third-generation aromatase inhibitors.
Topics: Anastrozole; Animals; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Drug Interactions; Enzyme Inhibitors; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Triazoles | 2003 |
The role of aromatase inhibitors in the treatment of metastatic breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Female; Humans; Letrozole; Neoplasm Metastasis; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Triazoles | 2003 |
Neoadjuvant tamoxifen and aromatase inhibitors: comparisons and clinical outcomes.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Ki-67 Antigen; Letrozole; Neoadjuvant Therapy; Nitriles; Randomized Controlled Trials as Topic; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles | 2003 |
Neoadjuvant comparisons of aromatase inhibitors and tamoxifen: pretreatment determinants of response and on-treatment effect.
Topics: Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Humans; Letrozole; Neoadjuvant Therapy; Neoplasms, Hormone-Dependent; Nitriles; Tamoxifen; Treatment Outcome; Triazoles | 2003 |
The pharmacology of letrozole.
Topics: Adrenocorticotropic Hormone; Animals; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Estradiol; Estrone; Humans; Letrozole; Nitriles; Triazoles | 2003 |
Challenges in the endocrine management of breast cancer.
Topics: Adult; Aged; Anastrozole; Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Letrozole; Mastectomy, Segmental; Mice; Middle Aged; Nitriles; Prognosis; Randomized Controlled Trials as Topic; Receptors, Estrogen; Risk Assessment; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles; United Kingdom | 2003 |
Aromatase inhibitors in breast cancer therapy.
Topics: Anastrozole; Androstadienes; Breast Neoplasms; Clinical Trials as Topic; Disease-Free Survival; Enzyme Inhibitors; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Triazoles | 2003 |
Synergistic effects of antiprogestins and iNOS or aromatase inhibitors on establishment and maintenance of pregnancy.
Topics: Animals; Aromatase Inhibitors; Embryo Implantation; Enzyme Inhibitors; Estrogens; Female; Hormone Antagonists; Humans; Immunohistochemistry; Letrozole; Mifepristone; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitriles; Pregnancy; Progestins; Rats; Time Factors; Triazoles | 2003 |
[Neoadjuvant endocrine therapy for breast cancer: an overview].
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Breast Neoplasms; Clinical Trials as Topic; Estrogen Antagonists; Female; Humans; Letrozole; Neoadjuvant Therapy; Nitriles; Tamoxifen; Triazoles | 2004 |
[Controversies in endocrine therapy for breast cancer].
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Enzyme Inhibitors; Estrogen Replacement Therapy; Female; Humans; Letrozole; Mastectomy, Segmental; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Receptors, Estrogen; Receptors, Progesterone; Risk Factors; Tamoxifen; Triazoles | 2004 |
Importance of correlative science in advancing hormonal therapy and a new clinical paradigm for neoadjuvant therapy.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Disease Progression; Female; Gene Expression Profiling; Humans; Letrozole; Nitriles; Oligonucleotide Array Sequence Analysis; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles | 2004 |
Aromatase inhibitors for breast cancer in postmenopausal women.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Enzyme Inhibitors; Female; Humans; Letrozole; Megestrol Acetate; Nitriles; Postmenopause; Receptors, Estrogen; Tamoxifen; Triazoles | 2004 |
Aromatase inhibitors: current indications and future prospects for treatment of postmenopausal breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Drug Approval; Drug Interactions; Economics, Pharmaceutical; Female; Forecasting; Geriatrics; Humans; Letrozole; Neoadjuvant Therapy; Nitriles; Patient Selection; Postmenopause; Practice Patterns, Physicians'; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Treatment Outcome; Triazoles; United States; United States Food and Drug Administration | 2004 |
Aromatase inhibitors in the adjuvant setting: bringing the gold to a standard?
Topics: Aged; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Enzyme Inhibitors; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles | 2004 |
Aromatase inhibition in the treatment of advanced breast cancer: is there a relationship between potency and clinical efficacy?
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Middle Aged; Nitriles; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles | 2004 |
Letrozole: a review of its use in postmenopausal women with breast cancer.
Topics: Antineoplastic Agents; Area Under Curve; Aromatase Inhibitors; Biological Availability; Breast Neoplasms; Cost-Benefit Analysis; Drug Tolerance; Economics, Pharmaceutical; Enzyme Inhibitors; Female; Half-Life; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Severity of Illness Index; Triazoles | 2004 |
Overcoming endocrine therapy resistance by signal transduction inhibition.
Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Drug Resistance, Neoplasm; Farnesyltranstransferase; Humans; Immunosuppressive Agents; Letrozole; Nitriles; Receptor, ErbB-2; Receptors, Estrogen; Sirolimus; Tamoxifen; Triazoles | 2004 |
[Aromatase inhibitors in the adjuvant therapy of breast carcinomas].
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Patient Care Management; Practice Guidelines as Topic; Practice Patterns, Physicians'; Tamoxifen; Treatment Outcome; Triazoles | 2004 |
Endocrine approaches for the treatment of early and advanced breast cancer in postmenopausal women.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase; Breast Neoplasms; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Humans; Letrozole; Nitriles; Postmenopause; Tamoxifen; Triazoles | 2004 |
Current developments in hormonal therapy of breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles | 2004 |
The role of aromatase inhibitors in the adjuvant treatment of breast carcinoma: the M. D. Anderson Cancer Center evidence-based approach.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Enzyme Inhibitors; Evidence-Based Medicine; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Prospective Studies; Tamoxifen; Triazoles | 2004 |
Role of aromatase inhibitors in the treatment of breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Triazoles | 2004 |
[Tamoxifen and aromatase inhibitors in the treatment of breast cancer in menopausal women: pharmacological and clinical aspects].
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Estrogen Antagonists; Female; Humans; Letrozole; Menopause; Neoplasms, Hormone-Dependent; Nitriles; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles | 2004 |
Advances in endocrine therapy for breast cancer: considering efficacy, safety, and quality of life.
Topics: Algorithms; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Decision Trees; Drug Administration Schedule; Drug Monitoring; Estradiol; Female; Fulvestrant; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Nurse's Role; Oncology Nursing; Patient Education as Topic; Patient Selection; Postmenopause; Quality of Life; Safety; Selective Estrogen Receptor Modulators; Social Support; Tamoxifen; Treatment Outcome; Triazoles | 2004 |
Aromatase inhibitors and breast cancer: time for a change?
Topics: Aged; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Cost-Benefit Analysis; Female; Humans; Letrozole; Multicenter Studies as Topic; Nitriles; Randomized Controlled Trials as Topic; Risk Factors; Tamoxifen; Treatment Outcome; Triazoles | 2004 |
Therapeutic observations in MCF-7 aromatase xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase; Aromatase Inhibitors; Disease Models, Animal; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Humans; Letrozole; Mammary Neoplasms, Experimental; Mice; Nitriles; Receptors, Estrogen; Triazoles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2005 |
Using aromatase inhibitors in the neoadjuvant setting: evolution or revolution?
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Evidence-Based Medicine; Female; Humans; Letrozole; Mastectomy, Segmental; Neoadjuvant Therapy; Nitriles; Randomized Controlled Trials as Topic; Receptors, Estrogen; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles | 2005 |
Aromatase inhibitors in advanced breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Neoplasm Metastasis; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Triazoles | 2004 |
Aromatase inhibitors in early breast cancer therapy.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Female; Humans; Letrozole; Neoadjuvant Therapy; Nitriles; Postmenopause; Triazoles | 2004 |
Changing clinical practice: extending the benefits of adjuvant endocrine therapy in breast cancer.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Drug Resistance, Neoplasm; Female; Humans; Letrozole; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles | 2004 |
Optimizing bisphosphonate therapy in patients with breast cancer on endocrine therapy.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Clinical Trials as Topic; Diphosphonates; Female; Humans; Ibandronic Acid; Imidazoles; Letrozole; Nitriles; Pamidronate; Postmenopause; Triazoles; Zoledronic Acid | 2004 |
Aromatase inhibitors in the management of early breast cancer: optimizing the clinical benefit.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Bone Resorption; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles | 2004 |
Innovations in antineoplastic therapy.
Topics: Adjuvants, Immunologic; Alemtuzumab; Aminoglycosides; Anastrozole; Androstadienes; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neoplasm; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Benzamides; Bile; Boronic Acids; Bortezomib; Capecitabine; Cetuximab; Decanoic Acids; Deoxycytidine; Docetaxel; Drug Approval; Estradiol; Fluorouracil; Fulvestrant; Gefitinib; Gemtuzumab; Humans; Imatinib Mesylate; Letrozole; Leuprolide; Nitriles; Oligopeptides; Organoplatinum Compounds; Oxaliplatin; Oxides; Piperazines; Polyesters; Pyrazines; Pyrimidines; Quinazolines; Taxoids; Thionucleotides; Tissue Extracts; Triazoles; United States; United States Food and Drug Administration; Vidarabine Phosphate | 2005 |
Successful use of letrozole in male breast cancer: a case report and review of hormonal therapy for male breast cancer.
Topics: Aged; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms, Male; Carcinoma, Ductal, Breast; Humans; Letrozole; Male; Nitriles; Triazoles | 2005 |
Cost-effectiveness of letrozole versus tamoxifen as first-line hormonal therapy in treating postmenopausal women with advanced breast cancer in Japan.
Topics: Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Cost-Benefit Analysis; Drug Administration Schedule; Female; Humans; Letrozole; Middle Aged; National Health Programs; Nitriles; Postmenopause; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles | 2005 |
Aromatase inhibition: translation into a successful therapeutic approach.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Estrogens; Female; Humans; Letrozole; Molecular Structure; Nitriles; Triazoles | 2005 |
[Aromatase inhibitors in adjuvant setting in breast cancer].
Topics: Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Menopause; Nitriles; Triazoles | 2004 |
A comparison of fulvestrant and the third-generation aromatase inhibitors in the second-line treatment of postmenopausal women with advanced breast cancer.
Topics: Aged; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase III as Topic; Drug Resistance, Neoplasm; Estradiol; Female; Fulvestrant; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Tamoxifen; Triazoles | 2005 |
Long-term risk of breast cancer recurrence: the need for extended adjuvant therapy.
Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Drug Resistance; Estrogen Receptor Modulators; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Receptors, Estrogen; Receptors, Progesterone; Risk Assessment; Tamoxifen; Time Factors; Triazoles | 2005 |
Aromatase inhibitors for therapy of advanced breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase III as Topic; Drug Evaluation; Female; Humans; Letrozole; Megestrol Acetate; Nitriles; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles | 2005 |
[Consensus Meeting of the 9th International Conference on Primary Therapy of Early Breast Cancer (St. Gall, January 26-29, 2005)].
Topics: Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Disease-Free Survival; Female; Humans; Letrozole; Neoplasm Staging; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Tamoxifen; Triazoles | 2005 |
The aromatase inhibitors in early breast cancer: who, when, and why?
Topics: Anastrozole; Aromatase Inhibitors; Breast Neoplasms; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Letrozole; Nitriles; Patient Selection; Selective Estrogen Receptor Modulators; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles | 2005 |
Clinical and biomarker endpoint analysis in neoadjuvant endocrine therapy trials.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Clinical Trials as Topic; Endpoint Determination; Female; Humans; Ki-67 Antigen; Letrozole; Neoadjuvant Therapy; Nitriles; Tamoxifen; Treatment Outcome; Triazoles | 2005 |
Letrozole in the treatment of breast cancer.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Binding Sites; Breast Neoplasms; Female; Humans; Letrozole; Models, Molecular; Nitriles; Triazoles | 2005 |
Safety considerations of adjuvant therapy in early breast cancer in postmenopausal women.
Topics: Aged; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Controlled Clinical Trials as Topic; Estrogen Receptor Modulators; Female; Humans; Letrozole; Middle Aged; Neoplasm Staging; Nitriles; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles | 2005 |
New aromatase inhibitors as second-line endocrine therapy in postmenopausal patients with metastatic breast carcinoma: a pooled analysis of the randomized trials.
Topics: Aged; Anastrozole; Androstenedione; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Carcinoma; Clinical Trials, Phase III as Topic; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Fadrozole; Female; Humans; Letrozole; Middle Aged; Neoplasm Staging; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Probability; Prognosis; Remission Induction; Risk Assessment; Survival Analysis; Triazoles | 2005 |
Recent advances in the use of aromatase inhibitors for women with postmenopausal breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Female; Humans; Letrozole; Nitriles; Postmenopause; Triazoles | 2005 |
Benefit with aromatase inhibitors in the adjuvant setting for postmenopausal women with breast cancer.
Topics: Anastrozole; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Female; Humans; Letrozole; Nitriles; Postmenopause; Triazoles | 2005 |
Letrozole as adjuvant endocrine therapy in postmenopausal women with breast cancer.
Topics: Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Disease-Free Survival; Female; Humans; Letrozole; Middle Aged; Neoadjuvant Therapy; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles | 2006 |
Use of aromatase inhibitors in children with short stature.
Topics: Adult; Aminoglutethimide; Androstenedione; Aromatase Inhibitors; Body Height; Child; Estrogens; Female; Growth Disorders; Humans; Letrozole; Male; Musculoskeletal System; Nitriles; Triazoles | 2004 |
Review of the development of letrozole and its use in advanced breast cancer and in the neoadjuvant setting.
Topics: Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Drug Administration Schedule; Female; Humans; Letrozole; Neoadjuvant Therapy; Neoplasm Metastasis; Nitriles; Salvage Therapy; Triazoles | 2006 |
The extended adjuvant NCIC CTG MA.17 trials: initial and rerandomization studies.
Topics: Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Letrozole; Nitriles; Ontario; Randomized Controlled Trials as Topic; Research Design; Triazoles | 2006 |
The evolving role of letrozole in the adjuvant setting: first results from the large, phase III, randomized trial BIG 1-98.
Topics: Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Female; Humans; Letrozole; Nitriles; Randomized Controlled Trials as Topic; Triazoles | 2006 |
Improving bone health in patients with early breast cancer by adding bisphosphonates to letrozole: the Z-ZO-E-ZO-FAST program.
Topics: Aromatase Inhibitors; Bone Density; Breast Neoplasms; Diphosphonates; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Imidazoles; Letrozole; Nitriles; Osteoporosis, Postmenopausal; Randomized Controlled Trials as Topic; Triazoles; Zoledronic Acid | 2006 |
[Interactions between radiation and hormonal therapy in breast cancer: simultaneous or sequential treatment].
Topics: Animals; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Disease Models, Animal; Drug Administration Schedule; Female; Humans; Letrozole; Nitriles; Radiation-Sensitizing Agents; Radiotherapy, Adjuvant; Randomized Controlled Trials as Topic; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles | 2006 |
Letrozole : in postmenopausal hormone-responsive early-stage breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Humans; Letrozole; Male; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Selective Estrogen Receptor Modulators; Tamoxifen; Thromboembolism; Triazoles; Venous Thrombosis | 2006 |
Emerging data on optimal adjuvant endocrine therapy: Breast International Group trial 1-98/MA.17.
Topics: Aged; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles | 2006 |
A new era in ovulation induction.
Topics: Aromatase Inhibitors; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Follicle Stimulating Hormone; Hormones; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation; Ovulation Induction; Pregnancy; Pregnancy Rate; Superovulation; Triazoles | 2006 |
Extended breast cancer treatment with an aromatase inhibitor (Letrozole) after tamoxifen: why, who and how long?
Topics: Aromatase Inhibitors; Breast Neoplasms; Drug Administration Schedule; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles | 2006 |
Adjuvant aromatase inhibitor therapy for early breast cancer: A review of the most recent data.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Female; Humans; Letrozole; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles | 2006 |
Letrozole: a pharmacoeconomic review of its use in postmenopausal women with breast cancer.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Cost-Benefit Analysis; Drug Costs; Female; Humans; Letrozole; Neoplasm Staging; Nitriles; Postmenopause; Quality-Adjusted Life Years; Tamoxifen; Treatment Outcome; Triazoles | 2006 |
Future directions in the treatment of hormone-sensitive advanced breast cancer: the RAD001 (Everolimus)-letrozole clinical program.
Topics: Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Everolimus; Female; Forecasting; Humans; Immunosuppressive Agents; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Receptors, Estrogen; Sirolimus; Triazoles | 2006 |
Extended adjuvant therapy with letrozole: reducing the risk of recurrence.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Letrozole; Lymphatic Metastasis; Neoplasm Recurrence, Local; Nitriles; Tamoxifen; Triazoles | 2006 |
[Introduction of new drug: letrozole, a new non-steroidal aromatase inhibitor for the treatment of postmenopausal women with breast cancer].
Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Female; Humans; Letrozole; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Survival Rate; Tamoxifen; Triazoles | 2006 |
Breast cancer (metastatic).
Topics: Antibodies, Monoclonal; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Bone Neoplasms; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Progestins; Tamoxifen; Taxoids; Triazoles | 2006 |
Survival with aromatase inhibitors and inactivators versus standard hormonal therapy in advanced breast cancer: meta-analysis.
Topics: Adult; Aged; Aminoglutethimide; Anastrozole; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Fadrozole; Female; Humans; Letrozole; Middle Aged; Neoplasm Staging; Neoplasms, Hormone-Dependent; Nitriles; Odds Ratio; Randomized Controlled Trials as Topic; Survival Analysis; Triazoles | 2006 |
Bone safety of aromatase inhibitors versus tamoxifen.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Bone Density; Breast Neoplasms; Female; Fractures, Bone; Humans; Letrozole; Nitriles; Postmenopause; Tamoxifen; Triazoles | 2006 |
Update on the use of aromatase inhibitors in breast cancer.
Topics: Anastrozole; Androstadienes; Animals; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Triazoles | 2006 |
Refining the postmenopausal breast cancer treatment paradigm: the FACE trial.
Topics: Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase III as Topic; Female; Humans; Letrozole; Multicenter Studies as Topic; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Triazoles | 2006 |
Neoadjuvant endocrine therapy in breast cancer.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Female; Goserelin; Humans; Letrozole; Neoadjuvant Therapy; Nitriles; Patient Selection; Tamoxifen; Triazoles | 2007 |
Continuing with letrozole offers greater benefits.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Quality of Life; Survival Analysis; Time Factors; Treatment Outcome; Triazoles | 2007 |
Economic evaluation of the prevention and treatment of breast cancer--present status and open issues.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Cost-Benefit Analysis; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Quality-Adjusted Life Years; Tamoxifen; Triazoles | 2007 |
[Optimal adjuvant hormone therapy in postmenopausal women with hormone-sensitive mammary carcinoma: tamoxifen and the aromatase inhibitors anastrozole, exemestane and letrozole].
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Carcinoma; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Letrozole; Nitriles; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles | 2006 |
[Advancement in endocrine therapy for breast cancer].
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles | 2007 |
The Breast International Group 1-98 trial: big results for women with hormone-sensitive early breast cancer.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Female; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles | 2007 |
New advances in ovulation induction.
Topics: Anastrozole; Aromatase Inhibitors; Clomiphene; Estrogen Antagonists; Female; Fertility Agents, Female; Gonadotropins; Humans; Infertility, Female; Letrozole; Nitriles; Ovary; Ovulation Induction; Pregnancy; Pregnancy Rate; Tamoxifen; Treatment Outcome; Triazoles | 2007 |
Prescribing extended adjuvant letrozole.
Topics: Aromatase Inhibitors; Breast Neoplasms; Canada; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Practice Guidelines as Topic; Practice Patterns, Physicians'; Randomized Controlled Trials as Topic; Triazoles | 2007 |
Hormonal therapies for early breast cancer: systematic review and economic evaluation.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Cost-Benefit Analysis; Drug Administration Schedule; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Quality-Adjusted Life Years; Survival Analysis; Tamoxifen; Time Factors; Triazoles | 2007 |
Letrozole: present and future role in the treatment of breast cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Postmenopause; Premenopause; Randomized Controlled Trials as Topic; Triazoles | 2007 |
[Antiestrogen treatment in postmenopausal patients with metastatic breast cancer].
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Humans; Letrozole; Nitriles; Postmenopause; Prognosis; Selective Estrogen Receptor Modulators; Tamoxifen; Treatment Outcome; Triazoles | 2007 |
Reducing the risk of late recurrence in hormone-responsive breast cancer.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Breast Neoplasms; Disease-Free Survival; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Nitriles; Receptors, Estrogen; Receptors, Progesterone; Risk Factors; Tamoxifen; Triazoles | 2007 |
The what, why and how of aromatase inhibitors: hormonal agents for treatment and prevention of breast cancer.
Topics: Anastrozole; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Cardiovascular Diseases; Chemotherapy, Adjuvant; Drug Resistance; Female; Humans; Letrozole; Musculoskeletal Diseases; Nitriles; Postmenopause; Premenopause; Tamoxifen; Thromboembolism; Triazoles | 2007 |
The early days of letrozole.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Drug Design; Drug Tolerance; Female; History, 20th Century; Humans; International Cooperation; Letrozole; Nitriles; Postmenopause; Triazoles | 2007 |
The discovery and mechanism of action of letrozole.
Topics: Aged; Animals; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Dose-Response Relationship, Drug; Female; Humans; Letrozole; Middle Aged; Molecular Structure; Neoadjuvant Therapy; Neoplasms, Hormone-Dependent; Nitriles; Receptors, Estrogen; Structure-Activity Relationship; Tamoxifen; Treatment Outcome; Triazoles | 2007 |
Safety of aromatase inhibitors in the adjuvant setting.
Topics: Anastrozole; Androstadienes; Animals; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Cardiovascular Diseases; Causality; Chemotherapy, Adjuvant; Comorbidity; Estrogen Receptor Modulators; Female; Hot Flashes; Humans; Incidence; Letrozole; Neoadjuvant Therapy; Neoplasms, Hormone-Dependent; Neoplasms, Second Primary; Nitriles; Osteoporosis; Rats; Survival Analysis; Tamoxifen; Triazoles | 2007 |
The patient experience.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Letrozole; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Nitriles; Patient Education as Topic; Postmenopause; Quality of Life; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles | 2007 |
Femara and the future: tailoring treatment and combination therapies with Femara.
Topics: Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Drug Resistance, Neoplasm; Female; Forecasting; Humans; Letrozole; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Nitriles; Receptors, Estrogen; Treatment Outcome; Triazoles | 2007 |
Reducing the risk for breast cancer recurrence after completion of tamoxifen treatment in postmenopausal women.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Letrozole; Nitriles; Postmenopause; Practice Guidelines as Topic; Quality of Life; Risk Assessment; Secondary Prevention; Tamoxifen; Treatment Outcome; Triazoles | 2007 |
Assisted reproduction and breast cancer.
Topics: Algorithms; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cryopreservation; Embryo Transfer; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Primary Ovarian Insufficiency; Quality of Life; Reproductive Techniques, Assisted; Tamoxifen; Triazoles | 2007 |
Update on the use of letrozole in breast cancer.
Topics: Animals; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Triazoles | 2007 |
Aromatase inhibitors: past, present and future in breast cancer therapy.
Topics: Aminoglutethimide; Androstadienes; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Fadrozole; Female; Humans; Letrozole; Nitriles; Triazoles | 2008 |
Beyond tamoxifen: extended and late extended endocrine therapy in postmenopausal early breast cancer.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Survival Analysis; Tamoxifen; Time Factors; Triazoles | 2008 |
Aromatase inhibitors in adjuvant therapy for hormone receptor positive breast cancer: a systematic review.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Survival Analysis; Tamoxifen; Time Factors; Treatment Outcome; Triazoles | 2008 |
Ovulation induction in polycystic ovary syndrome.
Topics: Adult; Anovulation; Aromatase Inhibitors; Body Mass Index; Clomiphene; Diathermy; Female; Fertility Agents, Female; Follicle Stimulating Hormone; Glucocorticoids; Humans; Hyperandrogenism; Hypoglycemic Agents; Insulin Resistance; Laparoscopy; Letrozole; Metformin; Nitriles; Ovulation Induction; Phenotype; Polycystic Ovary Syndrome; Pregnancy; Randomized Controlled Trials as Topic; Time Factors; Triazoles | 2008 |
The impact of adjuvant endocrine therapy on reducing the risk of distant metastases in hormone-responsive breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Disease-Free Survival; Evidence-Based Medicine; Letrozole; Neoplasm Metastasis; Neoplasm Staging; Nitriles; Quality of Life; Randomized Controlled Trials as Topic; Tamoxifen; Treatment Outcome; Triazoles | 2008 |
A review of the BIG results: the Breast International Group 1-98 trial analyses.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Disease-Free Survival; Female; Humans; Letrozole; Neoplasm Metastasis; Neoplasm Staging; Nitriles; Quality of Life; Tamoxifen; Treatment Outcome; Triazoles; United States | 2008 |
Choosing early adjuvant therapy for postmenopausal women with hormone-sensitive breast cancer: aromatase inhibitors versus tamoxifen.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Tamoxifen; Triazoles | 2008 |
Aromatase inhibitors in early breast-cancer treatment: The story so far.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Female; Humans; Letrozole; Nitriles; Triazoles | 2008 |
The role of endocrine therapies in reducing risk of recurrence in postmenopausal women with hormone receptor-positive breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Nurse Clinicians; Nurse Practitioners; Nurse's Role; Oncology Nursing; Patient Education as Topic; Patient Selection; Postmenopause; Receptors, Estrogen; Risk Factors; Tamoxifen; Time Factors; Treatment Outcome; Triazoles | 2008 |
Neoadjuvant endocrine therapy for breast cancer: past, present and future.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Female; Forecasting; Humans; Letrozole; Neoadjuvant Therapy; Neoplasms, Hormone-Dependent; Nitriles; Patient Selection; Postmenopause; Tamoxifen; Triazoles | 2008 |
Targeting breast cancer with hormonal treatment options.
Topics: Aftercare; Ambulatory Care; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Estrogen Receptor Modulators; Humans; Information Services; Internet; Letrozole; Nitriles; Nurse Practitioners; Patient Selection; Postmenopause; Practice Guidelines as Topic; Receptors, Estrogen; Tamoxifen; Treatment Outcome; Triazoles | 2008 |
The emerging role of aromatase inhibitors in the adjuvant management of breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Drug Therapy, Combination; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Randomized Controlled Trials as Topic; Tamoxifen; Treatment Outcome; Triazoles | 2006 |
Aromatase inhibitors for breast cancer: proven efficacy across the spectrum of disease.
Topics: Anastrozole; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Neoadjuvant Therapy; Neoplasm Staging; Nitriles; Tamoxifen; Treatment Outcome; Triazoles | 2008 |
[Adjuvant endocrine therapy in postmenopausal hormone-sensitive breast cancer: to start, to switch or to extend?].
Topics: Aged; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Drug Administration Schedule; Drug Resistance, Neoplasm; Estrogen Receptor Modulators; Female; Humans; Letrozole; Lymphatic Metastasis; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Quality of Life; Randomized Controlled Trials as Topic; Selective Estrogen Receptor Modulators; Tamoxifen; Treatment Outcome; Triazoles | 2008 |
HER-2-positive metastatic breast cancer: trastuzumab and beyond.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Capecitabine; Cisplatin; Deoxycytidine; Disease Progression; Doxorubicin; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Fluorouracil; Gemcitabine; Humans; Letrozole; Neoplasm Metastasis; Nitriles; Receptor, ErbB-2; Trastuzumab; Triazoles; Vinblastine; Vinorelbine | 2008 |
Never too late: reducing late breast cancer relapse risk.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Europe; Female; Humans; Letrozole; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Nitriles; Postmenopause; Risk Factors; Tamoxifen; Time Factors; Triazoles | 2008 |
Overcoming recurrence risk: extended adjuvant endocrine therapy.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Letrozole; Lymphatic Metastasis; Neoplasm Metastasis; Neoplasm Recurrence, Local; Nitriles; Postmenopause; Tamoxifen; Triazoles | 2008 |
Understanding the BIG results: Insights from the BIG 1-98 trial analyses.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Neoplasm Metastasis; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Receptors, Estrogen; Research Design; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles | 2008 |
[Problems and future direction of preoperative systemic therapy for patients with operable breast cancer].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Cyclophosphamide; Disease-Free Survival; Docetaxel; Doxorubicin; Female; Humans; Letrozole; Nitriles; Prednisone; Preoperative Care; Remission Induction; Survival Rate; Taxoids; Triazoles; Vincristine | 2008 |
[Ovulation induction by means of letrozole].
Topics: Aromatase Inhibitors; Clomiphene; Estrogen Antagonists; Female; Fertility Agents, Female; Humans; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Pregnancy, Multiple; Risk Factors; Treatment Outcome; Triazoles | 2009 |
Aromatase inhibitors and breast cancer.
Topics: Anastrozole; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Aromatase Inhibitors; Breast Neoplasms; Cell Division; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Humans; Letrozole; Nitriles; Receptor Cross-Talk; Transplantation, Heterologous; Trastuzumab; Triazoles | 2009 |
Future targets in endometriosis treatment: targeting the endometriotic implant.
Topics: Anastrozole; Angiogenesis Inhibitors; Animals; Aromatase Inhibitors; Clinical Trials as Topic; Endometriosis; Female; Humans; Letrozole; Molecular Structure; Nitriles; Triazoles | 2009 |
[Adjuvant breast cancer treatment with hormono-radiotherapy].
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles | 2009 |
Comparative review of anastrozole, letrozole and exemestane in the management of early breast cancer.
Topics: Anastrozole; Androstadienes; Animals; Breast Neoplasms; Disease Management; Early Detection of Cancer; Female; Humans; Letrozole; Nitriles; Randomized Controlled Trials as Topic; Triazoles | 2009 |
Letrozole: a review of its use in the treatment of postmenopausal women with hormone-responsive early breast cancer.
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Quality of Life; Randomized Controlled Trials as Topic; Survival Analysis; Triazoles | 2009 |
Clinical perspectives on the utility of aromatase inhibitors for the adjuvant treatment of breast cancer.
Topics: Adult; Aged; Anastrozole; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Female; Humans; Letrozole; Middle Aged; Neoplasm Staging; Nitriles; Postmenopause; Secondary Prevention; Survival Analysis; Tamoxifen; Triazoles; Women's Health | 2009 |
Exemestane as first-line therapy in postmenopausal women with recurrent or metastatic breast cancer.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Celecoxib; Estrogens; Female; Humans; Letrozole; Middle Aged; Multicenter Studies as Topic; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Pyrazoles; Randomized Controlled Trials as Topic; Recurrence; Salvage Therapy; Sulfonamides; Tamoxifen; Triazoles | 2010 |
Lapatinib plus letrozole for postmenopausal patients with advanced HER2(+)/HR(+) breast cancer.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Deoxycytidine; Drug Resistance, Neoplasm; ErbB Receptors; Female; Fluorouracil; Humans; Lapatinib; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Quinazolines; Receptor, ErbB-2; Trastuzumab; Triazoles | 2009 |
Aromatase inhibitors for female infertility: a systematic review of the literature.
Topics: Adult; Anastrozole; Aromatase Inhibitors; Clomiphene; Female; Fertilization in Vitro; Gonadotropins; Humans; Infant, Newborn; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Randomized Controlled Trials as Topic; Triazoles | 2009 |
Letrozole.
Topics: Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Neoadjuvant Therapy; Neoplasm Metastasis; Nitriles; Postmenopause; Triazoles | 2010 |
[Management of metastatic HER2-positive breast cancer: present and future].
Topics: Anastrozole; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Benzoquinones; Bevacizumab; Brain Neoplasms; Breast Neoplasms; Disease Progression; Female; Heart; Humans; Lactams, Macrocyclic; Lapatinib; Letrozole; Neoplasm Proteins; Nitriles; Quinazolines; Quinolines; Receptor, ErbB-2; Trastuzumab; Triazoles | 2010 |
Endometriosis: in search of optimal treatment.
Topics: Adalimumab; Anastrozole; Angiogenesis Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Aromatase Inhibitors; Endometriosis; Estrogen Receptor Modulators; Etanercept; Female; Gonadotropin-Releasing Hormone; Hormone Antagonists; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Letrozole; Nitriles; Pentoxifylline; Progesterone; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Triazoles; Tumor Necrosis Factor Decoy Receptors; Tumor Necrosis Factor-alpha | 2010 |
Systematic review of aromatase inhibitors in the first-line treatment for hormone sensitive advanced or metastatic breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Triazoles | 2010 |
Aromatase inhibitors in recurrent ovarian endometriomas: report of five cases with literature review.
Topics: Adult; Aromatase Inhibitors; Endometriosis; Female; Humans; Letrozole; Nitriles; Remission Induction; Triazoles | 2011 |
Letrozole for ovulation induction and controlled ovarian hyperstimulation.
Topics: Anovulation; Aromatase Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Letrozole; Nitriles; Ovulation Induction; Triazoles | 2010 |
Lapatinib: in postmenopausal women with hormone receptor-positive, HER2-positive metastatic breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; ErbB Receptors; Female; Humans; Lapatinib; Letrozole; Middle Aged; Neoplasm Metastasis; Nitriles; Postmenopause; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2; Triazoles | 2010 |
Recent advancement in nonsteroidal aromatase inhibitors for treatment of estrogen-dependent breast cancer.
Topics: Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Chromones; Coumarins; Female; Flavonoids; Humans; Letrozole; Nitriles; Receptors, Estrogen; Sulfonamides; Triazoles | 2010 |
Fertility preservation in women with breast cancer.
Topics: Aromatase Inhibitors; Breast Neoplasms; Counseling; Cryopreservation; Embryo, Mammalian; Female; Fertility; Gonadotropins; Heterozygote; Humans; Infertility, Female; Letrozole; Nitriles; Oocytes; Ovulation Induction; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles | 2010 |
Women and bone health: maximizing the benefits of aromatase inhibitor therapy.
Topics: Anastrozole; Androstadienes; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Bone Density; Bone Density Conservation Agents; Bone Remodeling; Breast Neoplasms; Colorectal Neoplasms; Denosumab; Diphosphonates; Female; Humans; Imidazoles; Letrozole; Nitriles; Osteoporosis; Osteoporosis, Postmenopausal; Randomized Controlled Trials as Topic; RANK Ligand; Secondary Prevention; Tamoxifen; Triazoles; Zoledronic Acid | 2010 |
The efficacy of HER2-targeted agents in metastatic breast cancer: a meta-analysis.
Topics: Anastrozole; Anthracyclines; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Clinical Trials as Topic; Deoxycytidine; Female; Fluorouracil; Humans; Lapatinib; Letrozole; Neoplasm Metastasis; Nitriles; Quinazolines; Receptor, ErbB-2; Taxoids; Trastuzumab; Treatment Outcome; Triazoles | 2011 |
Neoadjuvant endocrine therapy for postmenopausal patients with hormone receptor-positive early breast cancer: a new concept.
Topics: Aged; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase III as Topic; Female; Humans; Letrozole; Middle Aged; Neoadjuvant Therapy; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Receptor, ErbB-2; Receptors, Estrogen; Triazoles | 2011 |
When to start an aromatase inhibitor: now or later?
Topics: Anastrozole; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Cost-Benefit Analysis; Drug Administration Schedule; Female; Humans; Letrozole; Neoadjuvant Therapy; Neoplasm Metastasis; Neoplasm Recurrence, Local; Nitriles; Randomized Controlled Trials as Topic; Risk Assessment; Risk Factors; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles | 2011 |
Differences between the non-steroidal aromatase inhibitors anastrozole and letrozole--of clinical importance?
Topics: Anastrozole; Animals; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase III as Topic; Cytochrome P-450 CYP2D6; Female; Letrozole; Mice; Nitriles; Receptors, Estrogen; Receptors, Progesterone; Triazoles | 2011 |
Overview of adjuvant trials of aromatase inhibitors in early breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Receptors, Estrogen; Tamoxifen; Triazoles | 2011 |
Aromatase inhibition: a potential target for the management of recurrent or metastatic endometrial cancer by letrozole: more questions than answers?
Topics: Aromatase Inhibitors; Clinical Trials as Topic; Endometrial Neoplasms; Female; Humans; Letrozole; Neoplasm Metastasis; Neoplasm Recurrence, Local; Nitriles; Triazoles | 2011 |
Aromatase inhibitors for ovulation induction and ovarian stimulation.
Topics: Aromatase Inhibitors; Female; Humans; Letrozole; Nitriles; Ovarian Diseases; Ovulation Induction; Polycystic Ovary Syndrome; Triazoles | 2011 |
Effect of androgen supplementation or modulation on ovarian stimulation outcome in poor responders: a meta-analysis.
Topics: Androgens; Dehydroepiandrosterone; Female; Humans; Letrozole; Nitriles; Oocyte Retrieval; Ovulation Induction; Pregnancy; Pregnancy Rate; Randomized Controlled Trials as Topic; Testosterone; Triazoles | 2011 |
Meta-analysis of letrozole versus clomiphene citrate in polycystic ovary syndrome.
Topics: Clomiphene; Female; Fertility Agents, Female; Humans; Letrozole; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Randomized Controlled Trials as Topic; Treatment Outcome; Triazoles | 2011 |
[Neoadjuvant endocrine therapy for postmenopausal estrogen receptor-positive patients with breast cancer].
Topics: Anastrozole; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Neoadjuvant Therapy; Neoplasm Staging; Nitriles; Postmenopause; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Remission Induction; Triazoles | 2011 |
[Aromatase inhibitors and arthralgia].
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Arthralgia; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Female; Humans; Letrozole; Medication Adherence; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Quality of Life; Risk Factors; Triazoles | 2011 |
Interpreting Breast International Group (BIG) 1-98: a randomized, double-blind, phase III trial comparing letrozole and tamoxifen as adjuvant endocrine therapy for postmenopausal women with hormone receptor-positive, early breast cancer.
Topics: Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Double-Blind Method; Female; Humans; Letrozole; Nitriles; Randomized Controlled Trials as Topic; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles | 2011 |
Aromatase inhibitors in stimulated IVF cycles.
Topics: Aromatase Inhibitors; Clomiphene; Female; Fertilization in Vitro; Follicular Phase; Gonadotropins; Humans; Letrozole; Luteal Phase; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Triazoles | 2011 |
The emerging use of aromatase inhibitors for endometriosis treatment.
Topics: Anastrozole; Animals; Aromatase Inhibitors; Disease Models, Animal; Endometriosis; Endometrium; Estrogens; Female; Fertility; Humans; Letrozole; Mice; Nitriles; Ovary; Pelvic Pain; Rats; Triazoles | 2011 |
Use of aromatase inhibitors to treat endometriosis-related pain symptoms: a systematic review.
Topics: Anastrozole; Aromatase Inhibitors; Clinical Trials as Topic; Endometriosis; Female; Humans; Letrozole; Nitriles; Pain, Postoperative; Pelvic Pain; Triazoles | 2011 |
Treatment of recurrent endometrial stromal sarcoma with letrozole: a case report and literature review.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Endometrial Neoplasms; Female; Humans; Letrozole; Middle Aged; Nitriles; Recurrence; Sarcoma, Endometrial Stromal; Triazoles | 2010 |
Clinical and economic benefits of aromatase inhibitor therapy in early-stage breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Cost-Benefit Analysis; Female; Humans; Letrozole; Nitriles; Postmenopause; Survival Analysis; Triazoles | 2011 |
Management of patients with metastatic breast cancer.
Topics: Adult; Age Factors; Aged; Anastrozole; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Disease Management; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Delivery Systems; Estradiol; Female; Fulvestrant; Humans; Letrozole; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Nitriles; Prognosis; Randomized Controlled Trials as Topic; Risk Assessment; Survival Analysis; Treatment Outcome; Triazoles | 2011 |
Metaplastic breast carcinoma: a case report and systematic review of the literature.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Female; Humans; Letrozole; Metaplasia; Mixed Tumor, Malignant; Nitriles; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Triazoles | 2011 |
An overview of letrozole in postmenopausal women with hormone-responsive breast cancer.
Topics: Androgens; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Bone and Bones; Breast Neoplasms; Clinical Trials as Topic; Cytochrome P-450 Enzyme System; Estrogen Receptor Modulators; Female; Humans; Letrozole; Lipids; Nitriles; Postmenopause; Tamoxifen; Triazoles | 2011 |
Approval summary: letrozole (Femara® tablets) for adjuvant and extended adjuvant postmenopausal breast cancer treatment: conversion of accelerated to full approval.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Drug Approval; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles; United States; United States Food and Drug Administration | 2011 |
Estrogen-regulated synaptogenesis in the hippocampus: sexual dimorphism in vivo but not in vitro.
Topics: Animals; Aromatase; Aromatase Inhibitors; Cells, Cultured; Cerebral Cortex; Dendritic Spines; Estradiol; Estrus; Female; Hippocampus; Hypothalamus; Letrozole; Male; Nitriles; Rats; Receptors, Estrogen; Sex Factors; Synapses; Triazoles | 2012 |
Lapatinib and trastuzumab in combination with an aromatase inhibitor for the first-line treatment of metastatic hormone receptor-positive breast cancer which over-expresses human epidermal growth factor 2 (HER2): a systematic review and economic analysis.
Topics: Anastrozole; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Clinical Trials as Topic; Cost-Benefit Analysis; Disease-Free Survival; Female; Humans; Lapatinib; Letrozole; Nitriles; Quinazolines; Receptor, ErbB-2; Trastuzumab; Triazoles | 2011 |
Collision of three histologically distinct endometrial cancers of the uterus.
Topics: Aged; Aromatase Inhibitors; Carcinoma, Endometrioid; Chemotherapy, Adjuvant; Cystadenocarcinoma, Papillary; Endometrial Neoplasms; Female; Humans; Hysterectomy; Immunohistochemistry; Keratins; Letrozole; Lymphatic Metastasis; Mixed Tumor, Mullerian; Nitriles; Triazoles; Tumor Suppressor Protein p53 | 2012 |
Does hormonal therapy have a therapeutic role in metastatic primary small cell neuroendocrine breast carcinoma? Case report and literature review.
Topics: Aged, 80 and over; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Neuroendocrine; Carcinoma, Small Cell; Combined Modality Therapy; Female; Humans; Letrozole; Neoplasm Metastasis; Nitriles; Triazoles | 2012 |
[Progress in study of the structure, catalytic mechanism and inhibitors of aromatase].
Topics: Androstenedione; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Catalysis; Coumarins; Estrogens; Flavonoids; Humans; Inhibitory Concentration 50; Letrozole; Nitriles; Sesquiterpenes; Structure-Activity Relationship; Triazoles; Xanthones | 2012 |
Sorafenib in locally advanced or metastatic breast cancer.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Benzenesulfonates; Bevacizumab; Breast Neoplasms; Capecitabine; Clinical Trials as Topic; Deoxycytidine; Disease-Free Survival; Docetaxel; Double-Blind Method; Female; Fluorouracil; Gemcitabine; Humans; Letrozole; Niacinamide; Nitriles; Paclitaxel; Phenylurea Compounds; Pyridines; Randomized Controlled Trials as Topic; Receptor, ErbB-2; Sorafenib; Taxoids; Triazoles | 2012 |
[Progress of molecularly targeted therapy for breast cancer].
Topics: Ado-Trastuzumab Emtansine; Antibodies, Monoclonal, Humanized; Breast Neoplasms; Denosumab; Drug Design; Drug Therapy, Combination; Everolimus; Humans; Lapatinib; Letrozole; Maytansine; Molecular Targeted Therapy; Nitriles; Quinazolines; Receptor, ErbB-2; Sirolimus; Tamoxifen; Trastuzumab; Triazoles | 2012 |
AKT-aro and HER2-aro, models for de novo resistance to aromatase inhibitors; molecular characterization and inhibitor response studies.
Topics: Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Benzoquinones; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease-Free Survival; Drug Resistance, Neoplasm; Drug Synergism; Estradiol; Extracellular Signal-Regulated MAP Kinases; Female; Fulvestrant; Gene Expression Regulation, Neoplastic; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Letrozole; Nitriles; Proto-Oncogene Proteins c-akt; Receptor, ErbB-2; Receptors, Estrogen; Transcriptional Activation; Triazoles | 2012 |
Systematic review of lapatinib in combination with letrozole compared with other first-line treatments for hormone receptor positive(HR+) and HER2+ advanced or metastatic breast cancer(MBC).
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma; Disease Progression; Female; Humans; Lapatinib; Letrozole; Neoadjuvant Therapy; Neoplasm Metastasis; Nitriles; Quinazolines; Receptor, ErbB-2; Receptors, Cytoplasmic and Nuclear; Triazoles | 2012 |
Reproductive impact of polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Clomiphene; Female; Fertilization in Vitro; Humans; Infant, Newborn; Infertility, Female; Laparoscopy; Letrozole; Metformin; Nitriles; Obesity; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Outcome; Triazoles | 2012 |
Extended adjuvant endocrine therapy in hormone dependent breast cancer: the paradigm of the NCIC-CTG MA.17/BIG 1-97 trial.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles | 2013 |
Polycystic ovarian syndrome management options.
Topics: Clomiphene; Contraceptives, Oral, Hormonal; Estrogen Antagonists; Exercise; Female; Humans; Infertility, Female; Insulin Resistance; Letrozole; Menstruation Disturbances; Metformin; Nitriles; Obesity; Ovulation Induction; Polycystic Ovary Syndrome; Reproductive Techniques, Assisted; Risk Reduction Behavior; Triazoles; Weight Loss | 2012 |
Evaluation and treatment of anovulatory and unexplained infertility.
Topics: Anovulation; Clomiphene; Diet; Evidence-Based Medicine; Exercise; Female; Fertility Agents, Female; Glucocorticoids; Gonadotropins; Humans; Infertility, Female; Laparoscopy; Letrozole; Metformin; Nitriles; Obesity; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Risk Reduction Behavior; Triazoles; Weight Loss | 2012 |
Aromatase inhibitors in the treatment of elderly women with metastatic breast cancer.
Topics: Aged, 80 and over; Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Comorbidity; Disease Management; Disease Progression; Drug Therapy, Combination; Female; Geriatric Assessment; Health Status; Humans; Letrozole; Life Expectancy; Nitriles; Prognosis; Quality of Life; Treatment Outcome; Triazoles | 2013 |
Pharmacogenomics of endocrine therapy in breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Genome-Wide Association Study; Humans; Japan; Letrozole; Musculoskeletal Physiological Phenomena; Nitriles; Pharmacogenetics; Phenotype; Postmenopause; Raloxifene Hydrochloride; Randomized Controlled Trials as Topic; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles | 2013 |
Impact of metabolizing enzymes on drug response of endocrine therapy in breast cancer.
Topics: Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Pharmacological; Breast Neoplasms; Cytochrome P-450 CYP2D6; Female; Humans; Letrozole; Nitriles; Receptors, Estrogen; Tamoxifen; Triazoles | 2013 |
Big enough for an aromatase inhibitor? How adiposity affects male fertility.
Topics: Adiposity; Aromatase Inhibitors; Evidence-Based Medicine; Humans; Infertility, Male; Letrozole; Male; Nitriles; Obesity; Severity of Illness Index; Triazoles | 2013 |
Extended adjuvant endocrine therapy in hormone-receptor positive breast cancer.
Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Chemotherapy, Adjuvant; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Letrozole; Long-Term Care; Mastectomy, Segmental; Middle Aged; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Premenopause; Prognosis; Randomized Controlled Trials as Topic; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles | 2013 |
Postmenopausal women with hormone receptor-positive breast cancer: balancing benefit and toxicity from aromatase inhibitors.
Topics: Aged; Aged, 80 and over; Aromatase Inhibitors; Breast Neoplasms; Cardiovascular Diseases; Chemotherapy, Adjuvant; Drug-Related Side Effects and Adverse Reactions; Estrogen Antagonists; Female; Follow-Up Studies; Fractures, Bone; Humans; Letrozole; Mastectomy, Segmental; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Risk Assessment; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles | 2013 |
Personalized adjuvant therapies: lessons from the past: the opening address by the St. Gallen 2013 award recipient.
Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Awards and Prizes; Breast Neoplasms; Chemotherapy, Adjuvant; Consensus Development Conferences as Topic; Disease-Free Survival; Female; Genes, erbB-2; Humans; Letrozole; Mastectomy; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Postmenopause; Precision Medicine; Premenopause; Prognosis; Randomized Controlled Trials as Topic; Risk Assessment; Survival Analysis; Switzerland; Tamoxifen; Treatment Outcome; Triazoles | 2013 |
Obesity and endocrine therapy: host factors and breast cancer outcome.
Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Body Mass Index; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Kaplan-Meier Estimate; Letrozole; Middle Aged; Nitriles; Obesity; Postmenopause; Predictive Value of Tests; Premenopause; Prognosis; Proportional Hazards Models; Randomized Controlled Trials as Topic; Risk Assessment; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles | 2013 |
Aromatase inhibitors for uterine fibroids.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Female; Hot Flashes; Humans; Leiomyoma; Letrozole; Nitriles; Triazoles; Triptorelin Pamoate; Uterine Neoplasms | 2013 |
Co-targeting estrogen receptor and HER2 pathways in breast cancer.
Topics: Anastrozole; Androstadienes; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Estradiol; Everolimus; Female; Fulvestrant; Gefitinib; Humans; Lapatinib; Letrozole; Molecular Targeted Therapy; Nitriles; Quinazolines; Receptor, ErbB-2; Receptors, Estrogen; Signal Transduction; Sirolimus; Tamoxifen; Trastuzumab; Triazoles | 2014 |
Tamoxifen or letrozole versus standard methods for women with estrogen-receptor positive breast cancer undergoing oocyte or embryo cryopreservation in assisted reproduction.
Topics: Breast Neoplasms; Cryopreservation; Embryo, Mammalian; Female; Humans; Letrozole; Nitriles; Oocytes; Pregnancy; Receptors, Estrogen; Reproductive Techniques, Assisted; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles | 2013 |
Intermittent letrozole therapy for metastatic breast cancer: case reports and literature review.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase II as Topic; Female; Humans; Letrozole; Multicenter Studies as Topic; Neoplasm Staging; Neoplasms, Hormone-Dependent; Nitriles; Prognosis; Receptors, Estrogen; Review Literature as Topic; Triazoles | 2014 |
Effectiveness of the antagonist/letrozole protocol for treating poor responders undergoing in vitro fertilization/intracytoplasmic sperm injection: a systematic review and meta-analysis.
Topics: Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone; Humans; Letrozole; Male; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Systematic Reviews as Topic; Triazoles | 2014 |
Aromatase inhibitors for subfertile women with polycystic ovary syndrome.
Topics: Anastrozole; Aromatase Inhibitors; Birth Rate; Clomiphene; Coitus; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitriles; Ovary; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Outcome; Randomized Controlled Trials as Topic; Triazoles | 2014 |
The utility of metformin therapy in reproductive-aged women with polycystic ovary syndrome (PCOS).
Topics: Animals; Clomiphene; Female; Fertility Agents, Female; Humans; Hypoglycemic Agents; Letrozole; Metformin; Nitriles; Ovulation; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Complications; Triazoles | 2014 |
Letrozole versus clomiphene citrate for unexplained infertility: a systematic review and meta-analysis.
Topics: Abortion, Spontaneous; Bias; Clomiphene; Endometrium; Estradiol; Female; Follicle Stimulating Hormone; Humans; Infertility, Female; Letrozole; Nitriles; Pregnancy; Pregnancy Rate; Pregnancy, Multiple; Triazoles | 2014 |
Systemic therapy for patients with advanced human epidermal growth factor receptor 2-positive breast cancer: American Society of Clinical Oncology clinical practice guideline.
Topics: Ado-Trastuzumab Emtansine; Anastrozole; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Clinical Trials as Topic; Comorbidity; Docetaxel; Drug Administration Schedule; Evidence-Based Medicine; Female; Health Status Disparities; Healthcare Disparities; Humans; Lapatinib; Letrozole; Maytansine; Molecular Targeted Therapy; Nitriles; Quinazolines; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Societies, Medical; Taxoids; Trastuzumab; Treatment Outcome; Triazoles; United States | 2014 |
The optimal duration and selection of adjuvant endocrine therapy for breast cancer: how long is enough?
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Humans; Letrozole; Nitriles; Recurrence; Risk Factors; Tamoxifen; Time Factors; Triazoles | 2014 |
The evaluation of pre and post processing semen analysis parameters at the time of intrauterine insemination in couples diagnosed with male factor infertility and pregnancy rates based on stimulation agent. A retrospective cohort study.
Topics: Adult; Aromatase Inhibitors; Female; Humans; Infertility, Male; Insemination, Artificial, Homologous; Letrozole; Male; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Semen Analysis; Triazoles | 2014 |
Neoadjuvant chemotherapy in breast cancer: review of literature.
Topics: Anthracyclines; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Neoadjuvant Therapy; Nitriles; Patient Selection; Tamoxifen; Taxoids; Trastuzumab; Triazoles | 2013 |
Aromatase inhibitors in breast cancer prevention.
Topics: Anastrozole; Androstadienes; Anticarcinogenic Agents; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Neoplasm Invasiveness; Nitriles; Postmenopause; Risk; Triazoles | 2014 |
Random-start controlled ovarian hyperstimulation with letrozole for fertility preservation in cancer patients: case series and review of literature.
Topics: Aromatase Inhibitors; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Fertility Preservation; Humans; Letrozole; Lymphoma, Non-Hodgkin; Nitriles; Oocyte Retrieval; Ovarian Neoplasms; Ovulation Induction; Triazoles | 2014 |
Ovulation induction: once bitten, twice shy?
Topics: Aromatase Inhibitors; Female; Humans; Letrozole; Multiple Birth Offspring; Nitriles; Ovulation Induction; Pregnancy; Triazoles | 2015 |
Endocrine and reproductive effects of polycystic ovarian syndrome.
Topics: Adult; Clomiphene; Female; Fertility Agents, Female; Fertilization in Vitro; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Triazoles | 2015 |
Extended adjuvant endocrine therapy in hormone-receptor positive early breast cancer: current and future evidence.
Topics: Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles | 2015 |
The use of aromatase inhibitors for ovulation induction.
Topics: Adult; Aromatase Inhibitors; Birth Rate; Clomiphene; Coitus; Female; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Outcome; Randomized Controlled Trials as Topic; Treatment Outcome; Triazoles | 2015 |
Novel strategies in the management of polycystic ovary syndrome.
Topics: Adult; Clomiphene; Contraceptives, Oral, Combined; Female; Fertility Agents, Female; Fertilization in Vitro; Gonadotropins; Hirsutism; Humans; Infertility, Female; Letrozole; Life Style; Menstruation Disturbances; Metformin; Nitriles; Obesity; Ovulation Induction; Polycystic Ovary Syndrome; Precision Medicine; Pregnancy; Selective Estrogen Receptor Modulators; Triazoles; Weight Gain; Weight Loss | 2015 |
Palbociclib: first global approval.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Cyclin-Dependent Kinases; Drug Approval; Drug Interactions; Drugs, Investigational; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Neoplasm Staging; Nitriles; Piperazines; Protein Kinase Inhibitors; Pyridines; Triazoles; United States; United States Food and Drug Administration | 2015 |
Random-start ovarian stimulation in patients with cancer.
Topics: Adult; Aromatase Inhibitors; Chorionic Gonadotropin; Cryopreservation; Female; Fertility Preservation; Fertilization in Vitro; Follicle Stimulating Hormone; Humans; Infertility, Female; Letrozole; Luteal Phase; Neoplasms; Nitriles; Oocyte Retrieval; Oocytes; Ovulation Induction; Treatment Outcome; Triazoles | 2015 |
Enhancing Endocrine Therapy for Hormone Receptor-Positive Advanced Breast Cancer: Cotargeting Signaling Pathways.
Topics: Adult; Aged; Androstadienes; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Everolimus; Female; Humans; Letrozole; Middle Aged; Molecular Targeted Therapy; Nitriles; Piperazines; Protein Kinase Inhibitors; Pyridines; Receptors, Estrogen; Research Design; Signal Transduction; Triazoles | 2015 |
Palbociclib: A Novel Cyclin-Dependent Kinase Inhibitor for Hormone Receptor-Positive Advanced Breast Cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cyclin-Dependent Kinases; Disease-Free Survival; Estradiol; Female; Fulvestrant; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Piperazines; Pyridines; Randomized Controlled Trials as Topic; Receptor, ErbB-2; Triazoles; United States | 2015 |
Letrozole versus clomiphene citrate in polycystic ovary syndrome: systematic review and meta-analysis.
Topics: Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Live Birth; MEDLINE; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Prospective Studies; Randomized Controlled Trials as Topic; Triazoles | 2015 |
Development of cell-cycle checkpoint therapy for solid tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Aurora Kinase A; Biomarkers, Tumor; Breast Neoplasms; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Proliferation; Clinical Trials as Topic; Cyclin-Dependent Kinases; Disease-Free Survival; Estradiol; Estrogen Receptor Antagonists; Female; Fulvestrant; Humans; Letrozole; Molecular Targeted Therapy; Neoplasm Staging; Nitriles; Nuclear Proteins; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptor, ErbB-2; Receptors, Estrogen; Triazoles | 2015 |
Better Together: Targeted Combination Therapies in Breast Cancer.
Topics: Androstadienes; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Resistance, Neoplasm; Everolimus; Female; Humans; Lapatinib; Letrozole; Molecular Targeted Therapy; Nitriles; Piperazines; Protein Kinase Inhibitors; Pyridines; Quinazolines; Receptor, ErbB-2; Trastuzumab; Triazoles | 2015 |
Treatment strategies for the infertile polycystic ovary syndrome patient.
Topics: Anovulation; Antineoplastic Agents; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Fertilization in Vitro; Humans; Infertility, Female; Laparoscopy; Letrozole; Life Style; Metformin; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Triazoles | 2015 |
Network Meta-Analysis Comparing Overall Survival for Fulvestrant 500 mg Versus Alternative Therapies for Treatment of Postmenopausal, Estrogen Receptor-Positive Advanced Breast Cancer Following Failure on Prior Endocrine Therapy.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Disease-Free Survival; Dose-Response Relationship, Drug; Estradiol; Everolimus; Female; Fulvestrant; Humans; Letrozole; Megestrol Acetate; Network Meta-Analysis; Nitriles; Postmenopause; Receptors, Estrogen; Treatment Outcome; Triazoles | 2016 |
The benefits of other treatments than in vitro fertilization to aid conception in minimal and mild endometriosis.
Topics: Clomiphene; Endometriosis; Female; Fertility Agents, Female; Fertilization in Vitro; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Outcome; Pregnancy Rate; Reproductive Techniques, Assisted; Triazoles | 2016 |
Sex steroids in relation to cardiac structure and function in men.
Topics: Adult; Age Factors; Androgens; Animals; Aromatase Inhibitors; Echocardiography; Estradiol; Estrogens; Female; Heart; Hormone Replacement Therapy; Humans; Hypogonadism; Letrozole; Male; Myocardium; Nitriles; Sex Factors; Testosterone; Triazoles; Ultrasonography, Doppler; Ventricular Function | 2017 |
Mono-ovulation in women with polycystic ovary syndrome: a clinical review on ovulation induction.
Topics: Adult; Anovulation; Body Weight; Clomiphene; Female; Fertility Agents, Female; Gonadotropins; Humans; Infertility, Female; Letrozole; Life Style; Metformin; Nitriles; Overweight; Ovulation; Ovulation Induction; Patient Safety; Polycystic Ovary Syndrome; Randomized Controlled Trials as Topic; Reproductive Techniques, Assisted; Retrospective Studies; Triazoles | 2016 |
Endocrine therapy for hormone treatment-naïve advanced breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Breast Neoplasms; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Estradiol; Female; Fulvestrant; Humans; Letrozole; Nitriles; Piperazines; Pyridines; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles | 2016 |
The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance.
Topics: Anovulation; Aromatase Inhibitors; Clomiphene; Consensus; Female; Fertility Agents, Female; Fertilization in Vitro; Gonadotropins; Healthy Lifestyle; Humans; Infertility, Female; Letrozole; Metformin; Nitriles; Obesity; Ovarian Hyperstimulation Syndrome; Ovulation; Ovulation Induction; Polycystic Ovary Syndrome; Practice Guidelines as Topic; Pregnancy; Receptors, Gonadotropin; Triazoles | 2016 |
Extended adjuvant endocrine therapy in hormone-receptor-positive early breast cancer.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Letrozole; Nitriles; Randomized Controlled Trials as Topic; Receptors, Estrogen; Tamoxifen; Triazoles | 2016 |
Oocyte cryopreservation for fertility preservation in women with cancer.
Topics: Cryopreservation; Estradiol; Female; Fertility Preservation; Humans; Infertility, Female; Letrozole; Neoplasms; Nitriles; Oocyte Retrieval; Oocytes; Ovulation Induction; Pregnancy; Pregnancy Rate; Reproductive Techniques, Assisted; Triazoles | 2016 |
Mechanism of drug resistance in relation to site of metastasis: Meta-analyses of randomized controlled trials in advanced breast cancer according to anticancer strategy.
Topics: Anastrozole; Androstadienes; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma; Disease-Free Survival; Drug Resistance, Neoplasm; Estradiol; Everolimus; Female; Fulvestrant; Humans; Letrozole; Nitriles; Piperazines; Pyridines; Randomized Controlled Trials as Topic; Trastuzumab; Triazoles | 2016 |
Ovulation induction in polycystic ovary syndrome: Current options.
Topics: Anovulation; Anti-Obesity Agents; Aromatase Inhibitors; Bariatric Surgery; Clomiphene; Diet Therapy; Exercise Therapy; Female; Fertility Agents, Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Humans; Hypoglycemic Agents; Infertility, Female; Inositol; Insulin Resistance; Letrozole; Metformin; Nitriles; Obesity; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Selective Estrogen Receptor Modulators; Triazoles | 2016 |
Treatment strategies for women with WHO group II anovulation: systematic review and network meta-analysis
Topics: Anovulation; Clomiphene; Drug Therapy, Combination; Female; Humans; Infertility, Female; Letrozole; Metformin; Network Meta-Analysis; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Treatment Outcome; Triazoles | 2017 |
Identification of miRNAs as biomarkers for acquired endocrine resistance in breast cancer.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Exosomes; Female; Gene Expression Regulation, Neoplastic; Humans; Letrozole; MicroRNAs; Neoplasm Invasiveness; Neoplasm Metastasis; Nitriles; Signal Transduction; Tamoxifen; Triazoles | 2017 |
Clomiphene citrate and letrozole to reduce follicle-stimulating hormone consumption during ovarian stimulation: systematic review and meta-analysis.
Topics: Clomiphene; Embryo Transfer; Female; Fertilization in Vitro; Follicle Stimulating Hormone; Humans; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Outcome; Randomized Controlled Trials as Topic; Triazoles | 2017 |
ADJUVANT (HORMONAL) THERAPY AS A CAUSE OF BONE LOSS IN PATIENTS WITH BREAST CANCER (REVIEW OF LITERATURE).
Topics: Anastrozole; Androstadienes; Aromatase Inhibitors; Bone Density; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Estrogen Antagonists; Female; Humans; Letrozole; Nitriles; Osteoporosis; Postmenopause; Premenopause; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles | 2017 |
Effectiveness of co-treatment with traditional Chinese medicine and letrozole for polycystic ovary syndrome: a meta-analysis.
Topics: Female; Follicle Stimulating Hormone; Humans; Letrozole; Luteinizing Hormone; Medicine, Chinese Traditional; Nitriles; Polycystic Ovary Syndrome; Publication Bias; Randomized Controlled Trials as Topic; Triazoles | 2017 |
CDK4/6 inhibitors in HER2-positive breast cancer.
Topics: Breast Neoplasms; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Estradiol; Fulvestrant; Humans; Letrozole; Molecular Targeted Therapy; Nitriles; Protein Kinase Inhibitors; Receptor, ErbB-2; Triazoles | 2017 |
Comparison of palbociclib in combination with letrozole or fulvestrant with endocrine therapies for advanced/metastatic breast cancer: network meta-analysis.
Topics: Androstadienes; Antineoplastic Combined Chemotherapy Protocols; Bayes Theorem; Breast Neoplasms; Disease-Free Survival; Estradiol; Everolimus; Female; Fulvestrant; Humans; Letrozole; Network Meta-Analysis; Nitriles; Piperazines; Pyridines; Randomized Controlled Trials as Topic; Triazoles | 2017 |
Palbociclib: A Review in HR-Positive, HER2-Negative, Advanced or Metastatic Breast Cancer.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Clinical Trials as Topic; Estradiol; Female; Fulvestrant; Humans; Letrozole; Neoplasm Metastasis; Neoplasm Staging; Nitriles; Piperazines; Pyridines; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Survival Analysis; Triazoles | 2017 |
A current and comprehensive review of cyclin-dependent kinase inhibitors for the treatment of metastatic breast cancer.
Topics: Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Breast Neoplasms; Cyclin-Dependent Kinase 4; Disease-Free Survival; Estradiol; Female; Fulvestrant; Humans; Letrozole; Nitriles; Piperazines; Protein Kinase Inhibitors; Purines; Pyridines; Randomized Controlled Trials as Topic; Triazoles | 2017 |
Efficacy and safety of endocrine monotherapy as first-line treatment for hormone-sensitive advanced breast cancer: A network meta-analysis.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Breast Neoplasms; Disease-Free Survival; Estradiol; Female; Fulvestrant; Humans; Letrozole; Neoplasms, Hormone-Dependent; Network Meta-Analysis; Nitriles; Receptor, ErbB-2; Tamoxifen; Triazoles | 2017 |
Aromatase inhibitors: A new approach for controlling ovarian function in cattle.
Topics: Administration, Intravaginal; Animals; Aromatase Inhibitors; Breeding; Cattle; Estrous Cycle; Estrus Synchronization; Female; Insemination, Artificial; Letrozole; Nitriles; Ovarian Follicle; Ovary; Ovulation Induction; Reproduction; Triazoles | 2018 |
Risks and benefits from CDK inhibitors for advanced HR+ Her 2- breast cancer.
Topics: Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Breast Neoplasms; Cyclin-Dependent Kinases; Estradiol; Female; Fulvestrant; Humans; Letrozole; Nitriles; Piperazines; Protein Kinase Inhibitors; Purines; Pyridines; Randomized Controlled Trials as Topic; Receptor, ErbB-2; Receptors, Estrogen; Risk Assessment; Triazoles | 2017 |
In vitro fertilization treatments with the use of clomiphene citrate or letrozole.
Topics: Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Fertilization in Vitro; Gonadotropins; Humans; Infertility, Female; Letrozole; Nitriles; Ovarian Hyperstimulation Syndrome; Ovulation Induction; Pregnancy; Triazoles | 2017 |
Oral medications including clomiphene citrate or aromatase inhibitors with gonadotropins for controlled ovarian stimulation in women undergoing in vitro fertilisation.
Topics: Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone; Gonadotropins; Humans; Letrozole; Live Birth; Nitriles; Oocyte Retrieval; Ovarian Hyperstimulation Syndrome; Ovulation Induction; Pregnancy; Pregnancy Rate; Randomized Controlled Trials as Topic; Sperm Injections, Intracytoplasmic; Triazoles | 2017 |
Efficacy and safety in older patient subsets in studies of endocrine monotherapy versus combination therapy in patients with HR+/HER2- advanced breast cancer: a review.
Topics: Aged; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Disease-Free Survival; Estradiol; Female; Fulvestrant; Humans; Letrozole; Middle Aged; Neoplasm Staging; Nitriles; Piperazines; Pyridines; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Triazoles | 2018 |
Ovarian surgery for symptom relief in women with polycystic ovary syndrome.
Topics: Acne Vulgaris; Clomiphene; Female; Gonadotropins; Hirsutism; Humans; Laparoscopy; Letrozole; Menstruation Disturbances; Metformin; Nitriles; Ovary; Polycystic Ovary Syndrome; Punctures; Randomized Controlled Trials as Topic; Triazoles | 2017 |
The CDK4/6 inhibitor in HR-positive advanced breast cancer: A systematic review and meta-analysis.
Topics: Antineoplastic Agents; Breast Neoplasms; Cyclin-Dependent Kinases; Disease-Free Survival; Estradiol; Female; Fulvestrant; Humans; Letrozole; Neoplasm Staging; Nitriles; Receptor, ErbB-2; Receptors, Estrogen; Treatment Outcome; Triazoles | 2018 |
Aromatase inhibitors (letrozole) for subfertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anastrozole; Aromatase Inhibitors; Birth Rate; Clomiphene; Coitus; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Live Birth; Nitriles; Ovarian Hyperstimulation Syndrome; Ovary; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Outcome; Pregnancy, Multiple; Randomized Controlled Trials as Topic; Triazoles | 2018 |
Influence of the anti-oestrogens tamoxifen and letrozole on thyroid function in women with early and advanced breast cancer: A systematic review.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Estrogens; Female; Humans; Hypothyroidism; Letrozole; Neoplasm Recurrence, Local; Nitriles; Tamoxifen; Triazoles | 2023 |
Letrozole: Pharmacology, toxicity and potential therapeutic effects.
Topics: Aromatase Inhibitors; Breast Neoplasms; Estrogens; Female; Humans; Infertility, Female; Letrozole; Nitriles; Triazoles | 2022 |
440 trial(s) available for triazoles and letrozole
| Article | Year |
|---|---|
Use of ultrasensitive recombinant cell bioassay to measure estrogen levels in women with breast cancer receiving the aromatase inhibitor, letrozole.
Topics: Aromatase Inhibitors; Biological Assay; Breast Neoplasms; Estradiol; Female; Humans; Letrozole; Nitriles; Radioimmunoassay; Recombination, Genetic; Sensitivity and Specificity; Triazoles | 1995 |
Letrozole (CGS 20267). A phase I study of a new potent oral aromatase inhibitor of breast cancer.
Topics: Adult; Aged; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Estrogen Antagonists; Female; Humans; Letrozole; Middle Aged; Neoplasm Metastasis; Neoplasms, Hormone-Dependent; Nitriles; Remission Induction; Triazoles | 1995 |
Effects of Fadrozole (CGS 16949A) and Letrozole (CGS 20267) on the inhibition of aromatase activity in breast cancer patients.
Topics: Aromatase Inhibitors; Breast Neoplasms; Estradiol; Estrogens; Estrone; Fadrozole; Female; Humans; Letrozole; Middle Aged; Nitriles; Radioimmunoassay; Triazoles | 1994 |
Open dose-finding study of a new potent and selective nonsteroidal aromatase inhibitor, CGS 20 267, in healthy male subjects.
Topics: Administration, Oral; Adult; Aldosterone; Aromatase Inhibitors; Blood Pressure; Dose-Response Relationship, Drug; Estradiol; Estrone; Follicle Stimulating Hormone; Headache; Humans; Hydrocortisone; Letrozole; Luteinizing Hormone; Male; Middle Aged; Nitriles; Testosterone; Triazoles | 1993 |
Phase I study of the oral nonsteroidal aromatase inhibitor CGS 20267 in healthy postmenopausal women.
Topics: 17-alpha-Hydroxyprogesterone; Administration, Oral; Aged; Aldosterone; Androstenedione; Aromatase Inhibitors; Dose-Response Relationship, Drug; Estradiol; Estrone; Female; Follicle Stimulating Hormone; Humans; Hydrocortisone; Hydroxyprogesterones; Letrozole; Luteinizing Hormone; Male; Menopause; Middle Aged; Nitriles; Random Allocation; Testosterone; Thyrotropin; Time Factors; Triazoles | 1993 |
Phase I study of the oral nonsteroidal aromatase inhibitor CGS 20267 in postmenopausal patients with advanced breast cancer.
Topics: Aromatase Inhibitors; Breast Neoplasms; Estradiol; Estrone; Humans; Letrozole; Microsomes; Middle Aged; Nitriles; Triazoles | 1993 |
The efficacy of CGS 20267 in suppressing estrogen biosynthesis in patients with advanced stage breast cancer.
Topics: Aldosterone; Anti-Inflammatory Agents, Non-Steroidal; Aromatase Inhibitors; Breast Neoplasms; Cosyntropin; Estradiol; Estrogens; Estrone; Female; Humans; Hydrocortisone; Letrozole; Neoplasm Staging; Nitriles; Potassium; Sodium; Time Factors; Triazoles | 1993 |
Letrozole, a new oral non-steroidal aromastase inhibitor in treating postmenopausal patients with advanced breast cancer. A pilot study.
Topics: Adult; Aged; Aldosterone; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Estradiol; Estrone; Female; Humans; Hydrocortisone; Letrozole; Middle Aged; Nitriles; Pilot Projects; Triazoles | 1996 |
A randomized phase II trial of two dosage levels of letrozole as third-line hormonal therapy for women with metastatic breast carcinoma.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Drug Administration Schedule; Female; Humans; Letrozole; Neoplasm Metastasis; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Survival Rate; Triazoles | 1997 |
Comparative bioavailability of letrozole under fed and fasting conditions in 12 healthy subjects after a 2.5 mg single oral administration.
Topics: Absorption; Administration, Oral; Adult; Analysis of Variance; Area Under Curve; Aromatase Inhibitors; Biological Availability; Cross-Over Studies; Eating; Enzyme Inhibitors; Fasting; Food-Drug Interactions; Humans; Letrozole; Male; Nitriles; Reproducibility of Results; Tablets, Enteric-Coated; Triazoles | 1997 |
Absolute bioavailability of letrozole in healthy postmenopausal women.
Topics: Administration, Oral; Area Under Curve; Aromatase Inhibitors; Biological Availability; Biotransformation; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Female; Humans; Injections, Intravenous; Letrozole; Middle Aged; Nitriles; Postmenopause; Regression Analysis; Tissue Distribution; Triazoles | 1997 |
Letrozole, a new oral aromatase inhibitor for advanced breast cancer: double-blind randomized trial showing a dose effect and improved efficacy and tolerability compared with megestrol acetate.
Topics: Administration, Oral; Aged; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Disease Progression; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Letrozole; Megestrol Acetate; Middle Aged; Nitriles; Survival Rate; Triazoles | 1998 |
Letrozole, a new oral aromatase inhibitor: randomised trial comparing 2.5 mg daily, 0.5 mg daily and aminoglutethimide in postmenopausal women with advanced breast cancer. Letrozole International Trial Group (AR/BC3).
Topics: Administration, Oral; Aged; Aminoglutethimide; Antineoplastic Agents, Hormonal; Breast Neoplasms; Confidence Intervals; Disease Progression; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Letrozole; Middle Aged; Neoplasm Staging; Nitriles; Odds Ratio; Postmenopause; Prognosis; Survival Rate; Treatment Failure; Triazoles | 1998 |
In vivo measurement of aromatase inhibition by letrozole (CGS 20267) in postmenopausal patients with breast cancer.
Topics: Adult; Aged; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Estradiol; Estrone; Female; Humans; Letrozole; Middle Aged; Neoplasm Proteins; Nitriles; Postmenopause; Triazoles | 1995 |
Evaluation of tamoxifen plus letrozole with assessment of pharmacokinetic interaction in postmenopausal women with metastatic breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Interactions; Endocrinology; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles | 1999 |
Double-blind, randomised, multicentre endocrine trial comparing two letrozole doses, in postmenopausal breast cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Triazoles | 1999 |
Impact of tamoxifen on the pharmacokinetics and endocrine effects of the aromatase inhibitor letrozole in postmenopausal women with breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Tamoxifen; Triazoles | 1999 |
[Letrozole (Femara), a new aromatase inhibitor for advanced breast cancer].
Topics: Aged; Aminoglutethimide; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Disease-Free Survival; Enzyme Inhibitors; Female; Humans; Letrozole; Middle Aged; Nitriles; Survival Analysis; Treatment Failure; Treatment Outcome; Triazoles | 1999 |
Use of an aromatase inhibitor for induction of ovulation in patients with an inadequate response to clomiphene citrate.
Topics: Anovulation; Aromatase Inhibitors; Chorionic Gonadotropin; Endometrium; Enzyme Inhibitors; Estradiol; Female; Humans; Infertility, Female; Letrozole; Luteinizing Hormone; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Prospective Studies; Triazoles | 2001 |
Superior efficacy of letrozole versus tamoxifen as first-line therapy for postmenopausal women with advanced breast cancer: results of a phase III study of the International Letrozole Breast Cancer Group.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Double-Blind Method; Female; Humans; Letrozole; Logistic Models; Middle Aged; Nitriles; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles | 2001 |
A specific aromatase inhibitor and potential increase in adult height in boys with delayed puberty: a randomised controlled trial.
Topics: Adolescent; Aromatase Inhibitors; Body Height; Double-Blind Method; Drug Therapy, Combination; Humans; Letrozole; Male; Nitriles; Puberty, Delayed; Testosterone; Triazoles | 2001 |
Phase III, multicenter, double-blind, randomized study of letrozole, an aromatase inhibitor, for advanced breast cancer versus megestrol acetate.
Topics: Aged; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Letrozole; Megestrol Acetate; Middle Aged; Nitriles; Postmenopause; Proportional Hazards Models; Receptors, Estrogen; Receptors, Progesterone; Triazoles | 2001 |
Letrozole as primary medical therapy for locally advanced and large operable breast cancer.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Letrozole; Mastectomy, Segmental; Middle Aged; Neoadjuvant Therapy; Nitriles; Postmenopause; Receptors, Estrogen; Treatment Outcome; Triazoles | 2001 |
Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: evidence from a phase III randomized trial.
Topics: Antineoplastic Agents; Breast Neoplasms; Disease Progression; Double-Blind Method; ErbB Receptors; Estrogen Antagonists; Female; Humans; Letrozole; Logistic Models; Neoadjuvant Therapy; Nitriles; Odds Ratio; Postmenopause; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Prostaglandin; Tamoxifen; Treatment Outcome; Triazoles | 2001 |
Effect of age and single versus multiple dose pharmacokinetics of letrozole (Femara) in breast cancer patients.
Topics: Age Factors; Aged; Antineoplastic Agents; Area Under Curve; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Estrogens; Humans; Letrozole; Middle Aged; Nitriles; Triazoles | 2001 |
Role of low levels of endogenous estrogen in regulation of bone resorption in late postmenopausal women.
Topics: Aged; Aromatase Inhibitors; Bone Remodeling; Bone Resorption; Double-Blind Method; Enzyme Inhibitors; Estradiol; Estrogens; Estrone; Female; Humans; Letrozole; Menopause; Middle Aged; Nitriles; Osteoporosis, Postmenopausal; Prospective Studies; Triazoles | 2002 |
Influence of letrozole and anastrozole on total body aromatization and plasma estrogen levels in postmenopausal breast cancer patients evaluated in a randomized, cross-over study.
Topics: Aged; Anastrozole; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Chromatography, High Pressure Liquid; Cross-Over Studies; Enzyme Inhibitors; Estradiol; Estrogens; Estrone; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Radioimmunoassay; Triazoles | 2002 |
Preoperative treatment of postmenopausal breast cancer patients with letrozole: A randomized double-blind multicenter study.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Preoperative Care; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Treatment Outcome; Triazoles | 2001 |
Treatment of delayed male puberty: efficacy of aromatase inhibition.
Topics: Adolescent; Aromatase Inhibitors; Body Height; Bone Density; Bone Development; Double-Blind Method; Drug Therapy, Combination; Enzyme Inhibitors; Female; Forecasting; Gonadal Steroid Hormones; Growth; Hormones; Humans; Letrozole; Male; Nitriles; Puberty, Delayed; Testis; Testosterone; Triazoles | 2001 |
The role of sex steroids in the regulation of insulin sensitivity and serum lipid concentrations during male puberty: a prospective study with a P450-aromatase inhibitor.
Topics: Adolescent; Aromatase Inhibitors; Body Composition; Body Height; Body Weight; Double-Blind Method; Enzyme Inhibitors; Estradiol; Gonadal Steroid Hormones; Humans; Insulin; Insulin Resistance; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Letrozole; Lipids; Male; Nitriles; Prospective Studies; Puberty; Puberty, Delayed; Testosterone; Triazoles | 2002 |
Aromatase inhibition improves ovarian response to follicle-stimulating hormone in poor responders.
Topics: Aromatase Inhibitors; Chorionic Gonadotropin; Cohort Studies; Endometrium; Enzyme Inhibitors; Estradiol; Female; Follicle Stimulating Hormone; Humans; Insemination, Artificial; Letrozole; Menstrual Cycle; Nitriles; Ovarian Follicle; Ovulation Induction; Pregnancy; Prospective Studies; Triazoles | 2002 |
[Superiority of letrozole compared with tamoxifen as first line therapy of postmenopausal women with advanced breast cancer: results of a phase III study of the International Letrozole Breast Cancer Group].
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Nitriles; Palliative Care; Postmenopause; Survival Rate; Tamoxifen; Triazoles | 2002 |
[CGS 20267 (Letrozole), a new aromatase inhibitor: early phase II study for postmenopausal women with advanced breast cancer].
Topics: Adult; Aged; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Drug Administration Schedule; Enzyme Inhibitors; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Survival Rate; Triazoles | 2002 |
[CGS20267 (Letrozole), a new aromatase inhibitor: late phase II study for postmenopausal women with advanced or recurrent breast cancer (no. 1)--investigation of recommended clinical dose CGS20267 Study Group].
Topics: Adult; Aged; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Estrogens; Female; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Postmenopause; Survival Rate; Triazoles | 2002 |
[CGS20267 (Letrozole), a new aromatase inhibitor: late phase II study in postmenopausal women with advanced or recurrent breast cancer (no. 2)--evaluation of efficacy and safety at the recommended clinical dose CGS20267 Study Group].
Topics: Adult; Aged; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Drug Administration Schedule; Enzyme Inhibitors; Estrogens; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Survival Rate; Triazoles | 2002 |
Novel treatment of delayed male puberty with aromatase inhibitors.
Topics: Adolescent; Analysis of Variance; Aromatase Inhibitors; Biomarkers; Body Height; Bone Density; Bone Development; Double-Blind Method; Enzyme Inhibitors; Estradiol; Growth; Humans; Letrozole; Male; Nitriles; Predictive Value of Tests; Puberty, Delayed; Testosterone; Triazoles | 2002 |
Effects of the aromatase inhibitor letrozole on normal breast epithelial cell proliferation and metabolic indices in postmenopausal women: a pilot study for breast cancer prevention.
Topics: Administration, Oral; Aged; Biomarkers; Biopsy, Needle; Breast Diseases; Breast Neoplasms; Cell Division; Confidence Intervals; Drug Administration Schedule; Enzyme Inhibitors; Epithelial Cells; Female; Humans; Immunohistochemistry; Ki-67 Antigen; Letrozole; Middle Aged; Nitriles; Odds Ratio; Postmenopause; Primary Prevention; Probability; Receptors, Estrogen; Reference Values; Sensitivity and Specificity; Statistics, Nonparametric; Triazoles | 2002 |
CA125 response is associated with estrogen receptor expression in a phase II trial of letrozole in ovarian cancer: identification of an endocrine-sensitive subgroup.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Aromatase Inhibitors; CA-125 Antigen; Disease Progression; Enzyme Inhibitors; ErbB Receptors; Female; Humans; Immunoenzyme Techniques; Letrozole; Middle Aged; Nitriles; Ovarian Neoplasms; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Triazoles | 2002 |
A randomized double-blind comparison of the effects of clomiphene citrate and the aromatase inhibitor letrozole on ovulatory function in normal women.
Topics: Adolescent; Adult; Aromatase Inhibitors; Clomiphene; Double-Blind Method; Estrogen Antagonists; Fertility Agents, Female; Follicle Stimulating Hormone; Humans; Letrozole; Middle Aged; Nitriles; Ovulation; Pilot Projects; Triazoles | 2002 |
Selective aromatase inhibition for patients with androgen-independent prostate carcinoma.
Topics: Aged; Aged, 80 and over; Androgens; Antineoplastic Agents; Aromatase Inhibitors; Enzyme Inhibitors; Estradiol; Humans; Letrozole; Male; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Prostate-Specific Antigen; Prostatic Neoplasms; Sex Hormone-Binding Globulin; Testosterone; Triazoles | 2002 |
Double-blind randomised trial comparing the non-steroidal aromatase inhibitors letrozole and fadrozole in postmenopausal women with advanced breast cancer.
Topics: Administration, Oral; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Disease Progression; Double-Blind Method; Enzyme Inhibitors; Estradiol; Estrone; Fadrozole; Female; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Safety; Survival Rate; Triazoles | 2003 |
Serum HER-2/neu and response to the aromatase inhibitor letrozole versus tamoxifen.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Disease-Free Survival; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Estrogen Antagonists; Female; Humans; Letrozole; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasms, Hormone-Dependent; Nitriles; Receptor, ErbB-2; Switzerland; Tamoxifen; Treatment Outcome; Triazoles; United States | 2003 |
Phase III study of letrozole versus tamoxifen as first-line therapy of advanced breast cancer in postmenopausal women: analysis of survival and update of efficacy from the International Letrozole Breast Cancer Group.
Topics: Antineoplastic Agents; Breast Neoplasms; Cross-Over Studies; Disease-Free Survival; Double-Blind Method; Female; Humans; Letrozole; Nitriles; Postmenopause; Proportional Hazards Models; Survival Rate; Tamoxifen; Triazoles | 2003 |
Postmenopausal women who progress on fulvestrant ('Faslodex') remain sensitive to further endocrine therapy.
Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Disease Progression; Double-Blind Method; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Estradiol; Estrogen Receptor Modulators; Female; Follow-Up Studies; Fulvestrant; Humans; Letrozole; Megestrol Acetate; Middle Aged; Nitriles; Postmenopause; Retrospective Studies; Salvage Therapy; Treatment Outcome; Triazoles | 2003 |
Effects of suppression of estrogen action by the p450 aromatase inhibitor letrozole on bone mineral density and bone turnover in pubertal boys.
Topics: Adolescent; Aromatase Inhibitors; Biomarkers; Bone and Bones; Bone Density; Bone Development; Child; Collagen; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Femur Neck; Gonadal Steroid Hormones; Humans; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Letrozole; Male; Nitriles; Puberty; Spine; Testosterone; Triazoles | 2003 |
A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Letrozole; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Quality of Life; Survival Analysis; Tamoxifen; Triazoles | 2003 |
An open randomised trial of second-line endocrine therapy in advanced breast cancer. comparison of the aromatase inhibitors letrozole and anastrozole.
Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents, Hormonal; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Middle Aged; Nitriles; Triazoles | 2003 |
Letrozole inhibits tumor proliferation more effectively than tamoxifen independent of HER1/2 expression status.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Division; Double-Blind Method; ErbB Receptors; Female; Humans; Immunohistochemistry; Ki-67 Antigen; Letrozole; Neoadjuvant Therapy; Nitriles; Protein Biosynthesis; Proteins; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Trefoil Factor-1; Triazoles; Tumor Suppressor Proteins | 2003 |
A trial-based cost-effectiveness analysis of letrozole followed by tamoxifen versus tamoxifen followed by letrozole for postmenopausal advanced breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cost-Benefit Analysis; Cross-Over Studies; Drug Costs; Female; Humans; Letrozole; Life Tables; Nitriles; Postmenopause; Quality-Adjusted Life Years; Survival Analysis; Tamoxifen; Triazoles; United States | 2003 |
Letrozole versus tamoxifen in the treatment of advanced breast cancer and as neoadjuvant therapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Letrozole; Middle Aged; Neoadjuvant Therapy; Nitriles; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles | 2003 |
Novel treatment of short stature with aromatase inhibitors.
Topics: Adolescent; Aromatase Inhibitors; Body Height; Bone Density; Bone Development; Enzyme Inhibitors; Estradiol; Follicle Stimulating Hormone; Humans; Inhibins; Insulin; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Letrozole; Lipids; Luteinizing Hormone; Male; Nitriles; Prospective Studies; Puberty, Delayed; Testis; Testosterone; Triazoles | 2003 |
Celecoxib anti-aromatase neoadjuvant (CAAN) trial for locally advanced breast cancer: preliminary report.
Topics: Androstadienes; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Carcinoembryonic Antigen; Celecoxib; Enzyme Inhibitors; Female; Humans; Letrozole; Middle Aged; Neoadjuvant Therapy; Nitriles; Postmenopause; Pyrazoles; Sulfonamides; Treatment Outcome; Triazoles | 2003 |
Clomiphene citrate versus letrozole for ovarian stimulation: a pilot study.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Enzyme Inhibitors; Estradiol; Female; Fertility Agents, Female; Follicular Phase; Humans; Insemination, Artificial, Homologous; Letrozole; Luteal Phase; Luteinizing Hormone; Male; Nitriles; Ovarian Follicle; Ovulation Induction; Pilot Projects; Progesterone; Triazoles | 2003 |
Treatment of endometriosis and chronic pelvic pain with letrozole and norethindrone acetate: a pilot study.
Topics: Adult; Analysis of Variance; Aromatase Inhibitors; Bone Density; Contraceptives, Oral, Synthetic; Endometriosis; Enzyme Inhibitors; Female; Humans; Letrozole; Middle Aged; Nitriles; Norethindrone; Norethindrone Acetate; Pain Measurement; Parity; Pelvic Pain; Pilot Projects; Premenopause; Triazoles | 2004 |
Serum androgen bioactivity in adolescence: a longitudinal study of boys with constitutional delay of puberty.
Topics: Adolescent; Androgens; Drug Therapy, Combination; Enzyme Inhibitors; Humans; Letrozole; Longitudinal Studies; Male; Nitriles; Puberty, Delayed; Testosterone; Triazoles | 2004 |
Hormonal therapy with letrozole for relapsed epithelial ovarian cancer. Long-term results of a phase II study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Aromatase Inhibitors; Biomarkers, Tumor; CA-125 Antigen; Enzyme Inhibitors; Female; Humans; Immunohistochemistry; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Ovarian Neoplasms; Receptors, Estrogen; Receptors, Progesterone; Survival Analysis; Treatment Outcome; Triazoles | 2004 |
A randomized single-blind controlled trial of letrozole as a low-cost IVF protocol in women with poor ovarian response: a preliminary report.
Topics: Adult; Aromatase Inhibitors; Chorionic Gonadotropin; Cost Control; Dose-Response Relationship, Drug; Drug Resistance; Embryo Transfer; Estradiol; Female; Fertilization in Vitro; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Gonadotropins; Humans; Letrozole; Nitriles; Ovary; Pregnancy; Pregnancy Rate; Recombinant Proteins; Single-Blind Method; Treatment Outcome; Triazoles | 2004 |
Her2/neu expression predicts the response to antiaromatase neoadjuvant therapy in primary breast cancer: subgroup analysis from celecoxib antiaromatase neoadjuvant trial.
Topics: Aged; Aged, 80 and over; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Celecoxib; Cyclooxygenase Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Letrozole; Middle Aged; Neoadjuvant Therapy; Nitriles; Prognosis; Pyrazoles; Receptor, ErbB-2; Sulfonamides; Treatment Outcome; Triazoles | 2004 |
Phase III study of letrozole versus tamoxifen as first-line therapy of advanced breast cancer in postmenopausal women: analysis of survival and update of efficacy from the international letrozole breast cancer group.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cross-Over Studies; Female; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles | 2004 |
Aromatase inhibition reduces the dose of gonadotropin required for controlled ovarian hyperstimulation.
Topics: Adult; Aromatase Inhibitors; Female; Follicle Stimulating Hormone; Humans; Infertility, Female; Letrozole; Nitriles; Ovarian Follicle; Ovulation Induction; Polycystic Ovary Syndrome; Triazoles | 2004 |
The role of aromatase inhibitors in the adjuvant treatment of breast carcinoma: the M. D. Anderson Cancer Center evidence-based approach.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Enzyme Inhibitors; Evidence-Based Medicine; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Prospective Studies; Tamoxifen; Triazoles | 2004 |
Superiority of letrozole to tamoxifen in the first-line treatment of advanced breast cancer: evidence from metastatic subgroups and a test of functional ability.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Double-Blind Method; Female; Humans; Karnofsky Performance Status; Letrozole; Middle Aged; Neoplasm Metastasis; Nitriles; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles | 2004 |
Efficacy of first-line letrozole versus tamoxifen as a function of age in postmenopausal women with advanced breast cancer.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Disease Progression; Double-Blind Method; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Prognosis; Tamoxifen; Treatment Outcome; Triazoles | 2004 |
Giving patients a choice improves quality of life: a multi-centre, investigator-blind, randomised, crossover study comparing letrozole with anastrozole.
Topics: Administration, Oral; Aged; Aged, 80 and over; Anastrozole; Aromatase Inhibitors; Breast Neoplasms; Cross-Over Studies; Decision Making; Female; Humans; Letrozole; Middle Aged; Nitriles; Patient Participation; Postmenopause; Quality of Life; Single-Blind Method; Treatment Outcome; Triazoles | 2004 |
Acute effects of tamoxifen and third-generation aromatase inhibitors on menopausal symptoms of breast cancer patients.
Topics: Anastrozole; Aromatase Inhibitors; Belgium; Body Mass Index; Breast Neoplasms; Data Interpretation, Statistical; Demography; Dyspareunia; Female; Hot Flashes; Humans; Letrozole; Logistic Models; Memory Disorders; Menopause; Middle Aged; Musculoskeletal Diseases; Nitriles; Pain; Patient Selection; Prospective Studies; Randomized Controlled Trials as Topic; Surveys and Questionnaires; Tamoxifen; Time Factors; Triazoles; Urination Disorders; Vaginal Diseases; Withholding Treatment | 2004 |
A randomized trial of letrozole versus clomiphene citrate in women undergoing superovulation.
Topics: Abortion, Spontaneous; Adult; Aromatase Inhibitors; Clomiphene; Endometrium; Female; Fertility Agents, Female; Humans; Incidence; Infertility, Female; Insemination, Artificial; Letrozole; Nitriles; Ovarian Follicle; Pregnancy; Pregnancy Rate; Prospective Studies; Superovulation; Triazoles; Ultrasonography | 2004 |
Single-dose administration of an aromatase inhibitor for ovarian stimulation.
Topics: Aromatase Inhibitors; Female; Follicle Stimulating Hormone; Humans; Letrozole; Luteinizing Hormone; Nitriles; Ovulation Induction; Triazoles | 2005 |
Pubertal upregulation of erythropoiesis in boys is determined primarily by androgen.
Topics: Adolescent; Androgens; Aromatase Inhibitors; Child; Double-Blind Method; Drug Therapy, Combination; Erythrocytes; Erythropoiesis; Growth Hormone; Hemoglobins; Humans; Insulin-Like Growth Factor I; Letrozole; Male; Nitriles; Puberty; Puberty, Delayed; Testosterone; Treatment Outcome; Triazoles; Up-Regulation | 2005 |
Letrozole normalizes serum testosterone in severely obese men with hypogonadotropic hypogonadism.
Topics: Aromatase Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Estradiol; Gonadotropins, Pituitary; Humans; Hypogonadism; Letrozole; Male; Middle Aged; Nitriles; Obesity, Morbid; Pilot Projects; Sex Hormone-Binding Globulin; Testosterone; Triazoles | 2005 |
The effect of letrozole on bone age progression, predicted adult height, and adrenal gland function.
Topics: Adolescent; Adrenal Glands; Adrenocorticotropic Hormone; Aromatase Inhibitors; Body Height; Bone and Bones; Bone Development; Child; Child, Preschool; Growth Disorders; Humans; Letrozole; Male; Nitriles; Treatment Outcome; Triazoles | 2005 |
The influence of letrozole on serum lipid concentrations in postmenopausal women with primary breast cancer who have completed 5 years of adjuvant tamoxifen (NCIC CTG MA.17L).
Topics: Aged; Aromatase Inhibitors; Biological Availability; Breast Neoplasms; Chemotherapy, Adjuvant; Cholesterol, HDL; Cholesterol, LDL; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Letrozole; Middle Aged; Neoadjuvant Therapy; Nitriles; Postmenopause; Probability; Reference Values; Risk Assessment; Statistics, Nonparametric; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles | 2005 |
Fertility preservation in breast cancer patients: a prospective controlled comparison of ovarian stimulation with tamoxifen and letrozole for embryo cryopreservation.
Topics: Adult; Breast Neoplasms; Cryopreservation; Embryo, Mammalian; Female; Fertility; Humans; Letrozole; Nitriles; Ovulation Induction; Tamoxifen; Triazoles | 2005 |
Letrozole improves disease-free survival vs tamoxifen in adjuvant treatment of early breast cancer.
Topics: Aged; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Treatment Outcome; Triazoles | 2005 |
Efficacy of letrozole for advanced breast cancer in postmenopausal patients.
Topics: Administration, Oral; Antineoplastic Agents; Biomarkers; Breast Neoplasms; Disease Progression; Female; Follow-Up Studies; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Retrospective Studies; Treatment Outcome; Triazoles | 2005 |
Beta-interferon and interleukin-2 prolong more than three times the survival of 26 consecutive endocrine dependent breast cancer patients with distant metastases: an exploratory trial.
Topics: Breast Neoplasms; Combined Modality Therapy; Disease-Free Survival; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Immunotherapy; Interferon-beta; Interleukin-2; Letrozole; Multivariate Analysis; Neoplasm Metastasis; Nitriles; Selective Estrogen Receptor Modulators; Tamoxifen; Toremifene; Triazoles | 2005 |
Quality-adjusted survival in a crossover trial of letrozole versus tamoxifen in postmenopausal women with advanced breast cancer.
Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Cross-Over Studies; Double-Blind Method; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Quality of Life; Survival Analysis; Tamoxifen; Triazoles | 2005 |
Comparative assessment in young and elderly men of the gonadotropin response to aromatase inhibition.
Topics: Adult; Aged; Aged, 80 and over; Aging; Aromatase Inhibitors; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; Estradiol; Feedback, Physiological; Gonadotropins; Humans; Letrozole; Male; Nitriles; Triazoles | 2005 |
Randomized trial of letrozole following tamoxifen as extended adjuvant therapy in receptor-positive breast cancer: updated findings from NCIC CTG MA.17.
Topics: Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Incidence; Letrozole; Lymphatic Metastasis; Middle Aged; Nitriles; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles | 2005 |
Assessment of quality of life in MA.17: a randomized, placebo-controlled trial of letrozole after 5 years of tamoxifen in postmenopausal women.
Topics: Administration, Oral; Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Drug Administration Schedule; Female; Health Status; Humans; Letrozole; Middle Aged; Nitriles; Pain; Placebos; Postmenopause; Quality of Life; Tamoxifen; Treatment Outcome; Triazoles | 2005 |
Inhibition of estrogen biosynthesis with a potent aromatase inhibitor increases predicted adult height in boys with idiopathic short stature: a randomized controlled trial.
Topics: Absorptiometry, Photon; Adolescent; Aromatase Inhibitors; Body Height; Bone Density; Child; Double-Blind Method; Estrogen Antagonists; Femur Neck; Growth; Growth Disorders; Hormones; Humans; Letrozole; Lumbar Vertebrae; Male; Nitriles; Prognosis; Puberty; Triazoles | 2005 |
A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Female; Humans; Letrozole; Middle Aged; Neoplasms, Hormone-Dependent; Neoplasms, Second Primary; Nitriles; Postmenopause; Proportional Hazards Models; Receptors, Estrogen; Receptors, Progesterone; Secondary Prevention; Survival Rate; Tamoxifen; Triazoles | 2005 |
A randomized trial of superovulation with two different doses of letrozole.
Topics: Adult; Aromatase Inhibitors; Endometrium; Female; Humans; Insemination, Artificial; Letrozole; Nitriles; Ovarian Follicle; Ovulation Induction; Pregnancy; Pregnancy Rate; Prospective Studies; Triazoles | 2006 |
Efficacy of combined metformin-letrozole in comparison with metformin-clomiphene citrate in clomiphene-resistant infertile women with polycystic ovarian disease.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Resistance; Drug Therapy, Combination; Endometrium; Female; Fertility Agents, Female; Humans; Hypoglycemic Agents; Infertility, Female; Letrozole; Metformin; Nitriles; Polycystic Ovary Syndrome; Pregnancy; Single-Blind Method; Triazoles | 2006 |
Cost effectiveness of extended adjuvant letrozole in postmenopausal women after adjuvant tamoxifen therapy: the UK perspective.
Topics: Aged; Anticarcinogenic Agents; Antineoplastic Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Cohort Studies; Female; Humans; Letrozole; Markov Chains; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles | 2006 |
Proliferation, steroid receptors and clinical/pathological response in breast cancer treated with letrozole.
Topics: Aged; Aromatase Inhibitors; Breast Neoplasms; Cell Proliferation; Female; Humans; Ki-67 Antigen; Letrozole; Middle Aged; Neoadjuvant Therapy; Nitriles; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Treatment Outcome; Triazoles | 2006 |
Duration of letrozole treatment and outcomes in the placebo-controlled NCIC CTG MA.17 extended adjuvant therapy trial.
Topics: Aged; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Proportional Hazards Models; Receptors, Estrogen; Receptors, Progesterone; Selective Estrogen Receptor Modulators; Survival Analysis; Tamoxifen; Time Factors; Treatment Outcome; Triazoles | 2006 |
Letrozole vs. clomiphene citrate in patients with ovulatory infertility.
Topics: Administration, Oral; Adult; Anovulation; Clomiphene; Endometriosis; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Prospective Studies; Triazoles | 2006 |
Treatment with the aromatase inhibitor letrozole during adolescence increases near-final height in boys with constitutional delay of puberty.
Topics: Adolescent; Aromatase Inhibitors; Body Height; Estradiol; Follicle Stimulating Hormone; Humans; Letrozole; Luteinizing Hormone; Male; Nitriles; Prospective Studies; Puberty, Delayed; Testosterone; Time Factors; Triazoles | 2006 |
Use of letrozole versus clomiphene citrate combined with gonadotropins in intrauterine insemination cycles: a pilot study.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Combinations; Female; Fertility Agents, Female; Gonadotropins; Humans; Infertility; Insemination, Artificial, Homologous; Korea; Letrozole; Nitriles; Ovulation Induction; Pilot Projects; Pregnancy; Pregnancy Rate; Treatment Outcome; Triazoles | 2006 |
The use of early adjuvant aromatase inhibitor therapy: contributions from the BIG 1-98 letrozole trial.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Female; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Receptors, Estrogen; Receptors, Progesterone; Survival Rate; Tamoxifen; Treatment Outcome; Triazoles | 2006 |
Preventing relapse beyond 5 years: the MA.17 extended adjuvant trial.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Female; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Survival Rate; Tamoxifen; Treatment Outcome; Triazoles | 2006 |
Androgen priming using aromatase inhibitor and hCG during early-follicular-phase GnRH antagonist down-regulation in modified antagonist protocols.
Topics: Adult; Aromatase; Chorionic Gonadotropin; Enzyme Inhibitors; Female; Fertilization in Vitro; Follicular Phase; Gonadotropin-Releasing Hormone; Humans; Letrozole; Menstrual Cycle; Nitriles; Ovarian Follicle; Patient Selection; Sperm Injections, Intracytoplasmic; Triazoles | 2006 |
Effect of letrozole versus placebo on bone mineral density in women with primary breast cancer completing 5 or more years of adjuvant tamoxifen: a companion study to NCIC CTG MA.17.
Topics: Adult; Aged; Aged, 80 and over; Alkaline Phosphatase; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers; Bone Density; Breast Neoplasms; Canada; Chemotherapy, Adjuvant; Collagen Type I; Estrogen Receptor Modulators; Female; Humans; Letrozole; Middle Aged; Nitriles; Peptides; Tamoxifen; Treatment Outcome; Triazoles | 2006 |
Cost-effectiveness of aromatase inhibitor co-treatment for controlled ovarian stimulation.
Topics: Aromatase Inhibitors; Cost-Benefit Analysis; Costs and Cost Analysis; Endometrium; Female; Follicle Stimulating Hormone; Humans; Infertility, Male; Letrozole; Male; Menstrual Cycle; Nitriles; Ontario; Ovulation Induction; Pregnancy; Pregnancy Outcome; Triazoles | 2006 |
Randomized phase II trial of letrozole and letrozole plus low-dose metronomic oral cyclophosphamide as primary systemic treatment in elderly breast cancer patients.
Topics: Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Cyclophosphamide; Drug Administration Schedule; Female; Humans; Ki-67 Antigen; Letrozole; Middle Aged; Neoplasm Staging; Nitriles; Treatment Outcome; Triazoles; Vascular Endothelial Growth Factor A | 2006 |
Aromatase inhibitors in ovarian stimulation for IVF/ICSI: a pilot study.
Topics: Adult; Aromatase Inhibitors; Drug Therapy, Combination; Female; Fertilization in Vitro; Follicle Stimulating Hormone; Hormones; Humans; Infertility, Female; Infertility, Male; Letrozole; Male; Nitriles; Ovulation Induction; Pilot Projects; Recombinant Proteins; Sperm Injections, Intracytoplasmic; Triazoles | 2006 |
Letrozole versus human menopausal gonadotrophin in women undergoing intrauterine insemination.
Topics: Adult; Aromatase Inhibitors; Endometrium; Female; Follicular Phase; Humans; Infertility, Female; Insemination, Artificial, Homologous; Letrozole; Luteinization; Male; Menotropins; Nitriles; Ovarian Hyperstimulation Syndrome; Pilot Projects; Pregnancy; Pregnancy Rate; Triazoles | 2006 |
The combination of letrozole and trastuzumab as first or second-line biological therapy produces durable responses in a subset of HER2 positive and ER positive advanced breast cancers.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Letrozole; Middle Aged; Nitriles; Receptor, ErbB-2; Receptors, Estrogen; Trastuzumab; Triazoles | 2007 |
Blockade of oestrogen biosynthesis in peripubertal boys: effects on lipid metabolism, insulin sensitivity, and body composition.
Topics: Adolescent; Apolipoprotein A-I; Apolipoproteins B; Aromatase Inhibitors; Body Composition; Body Height; Body Mass Index; Carbohydrate Metabolism; Child; Cholesterol, HDL; Cohort Studies; Double-Blind Method; Estrogen Antagonists; Estrogens; Gonadotropins; Humans; Insulin Resistance; Letrozole; Lipid Metabolism; Male; Nitriles; Prospective Studies; Triazoles; Triglycerides | 2006 |
Serum insulin-like factor 3 levels during puberty in healthy boys and boys with Klinefelter syndrome.
Topics: Adolescent; Age Determination by Skeleton; Aromatase Inhibitors; Body Height; Child; Dwarfism; Health; Humans; Hyperandrogenism; Inhibins; Insulin; Klinefelter Syndrome; Letrozole; Luteinizing Hormone; Male; Nitriles; Organ Size; Placebos; Proteins; Puberty; Statistics as Topic; Testis; Testosterone; Triazoles | 2006 |
Preliminary experience with a low-cost stimulation protocol that includes letrozole and human menopausal gonadotropins in normal responders for assisted reproductive technologies.
Topics: Adult; Chemotherapy, Adjuvant; Drug Combinations; Female; Humans; Infertility; Letrozole; Menotropins; Nitriles; Ovulation Induction; Pilot Projects; Pregnancy; Pregnancy Outcome; Reproductive Techniques, Assisted; Treatment Outcome; Triazoles | 2006 |
Clinical outcomes of ethnic minority women in MA.17: a trial of letrozole after 5 years of tamoxifen in postmenopausal women with early stage breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Comorbidity; Disease-Free Survival; Ethnicity; Female; Humans; Letrozole; Mental Health; Middle Aged; Minority Groups; Nitriles; Pain; Patient Compliance; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles; White People | 2006 |
Comparison of the efficacy of the aromatase inhibitor letrozole and clomiphene citrate as adjuvants to recombinant follicle-stimulating hormone in controlled ovarian hyperstimulation: a prospective, randomized, blinded clinical trial.
Topics: Adult; Aromatase Inhibitors; Chemotherapy, Adjuvant; Clomiphene; Drug Combinations; Female; Fertility Agents, Female; Follicle Stimulating Hormone; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Recombinant Proteins; Single-Blind Method; Treatment Outcome; Triazoles | 2006 |
Role of aromatase inhibitor in ovulation induction in patients with poor response to clomiphene citrate.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Female; Humans; Infertility, Female; Letrozole; Nitriles; Ovarian Follicle; Ovulation Induction; Pregnancy; Prospective Studies; Triazoles | 2006 |
Serum epidermal growth factor receptor/HER-2 predicts poor survival in patients with metastatic breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Double-Blind Method; ErbB Receptors; Female; Humans; Letrozole; Middle Aged; Multivariate Analysis; Neoplasm Metastasis; Nitriles; Prognosis; Receptor, ErbB-2; Survival Analysis; Tamoxifen; Triazoles | 2006 |
Pilot study of the impact of letrozole vs. placebo on breast density in women completing 5 years of tamoxifen.
Topics: Adult; Aged; Aged, 80 and over; Aromatase Inhibitors; Breast Neoplasms; Drug Administration Schedule; Female; Humans; Letrozole; Mammography; Middle Aged; Nitriles; Pilot Projects; Selective Estrogen Receptor Modulators; Tamoxifen; Treatment Outcome; Triazoles | 2007 |
Zoledronic acid inhibits adjuvant letrozole-induced bone loss in postmenopausal women with early breast cancer.
Topics: Adult; Aged; Alkaline Phosphatase; Bone Density; Breast Neoplasms; Collagen Type I; Diphosphonates; Female; Humans; Imidazoles; Letrozole; Middle Aged; Nitriles; Osteoporosis, Postmenopausal; Peptides; Triazoles; Zoledronic Acid | 2007 |
Follicular phase dynamics with combined aromatase inhibitor and follicle stimulating hormone treatment.
Topics: Adult; Aromatase Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endometrium; Estradiol; Female; Follicle Stimulating Hormone; Follicular Phase; Humans; Infertility, Female; Letrozole; Luteinizing Hormone; Male; Nitriles; Ovulation Induction; Pregnancy; Progesterone; Treatment Outcome; Triazoles | 2007 |
Five years of letrozole compared with tamoxifen as initial adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer: update of study BIG 1-98.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Estrogen Antagonists; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Letrozole; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Proportional Hazards Models; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Time Factors; Treatment Outcome; Triazoles | 2007 |
Reduction in proliferation with six months of letrozole in women on hormone replacement therapy.
Topics: Adult; Aged; Anticarcinogenic Agents; Aromatase Inhibitors; Biomarkers; Biopsy, Fine-Needle; Breast Neoplasms; Cell Nucleus; Cell Proliferation; Down-Regulation; Estradiol; Estrogen Replacement Therapy; Female; Humans; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor Binding Proteins; Insulin-Like Growth Factor I; Ki-67 Antigen; Letrozole; Mammography; Middle Aged; Nitriles; Pilot Projects; Postmenopause; Receptors, Estrogen; Risk Assessment; Risk Factors; Testosterone; Time Factors; Treatment Outcome; Triazoles | 2007 |
NSABP B-42: a clinical trial to determine the efficacy of five years of letrozole compared with placebo in patients completing five years of hormonal therapy consisting of an aromatase inhibitor (AI) or tamoxifen followed by an AI in prolonging disease-fr
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Carcinoma; Chemotherapy, Adjuvant; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Letrozole; Neoplasm Staging; Nitriles; Patient Selection; Postmenopause; Tamoxifen; Triazoles | 2006 |
Predictors of early relapse in postmenopausal women with hormone receptor-positive breast cancer in the BIG 1-98 trial.
Topics: Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Follow-Up Studies; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Prognosis; Tamoxifen; Time Factors; Treatment Outcome; Triazoles | 2007 |
Letrozole and norethisterone acetate in rectovaginal endometriosis.
Topics: Administration, Oral; Aromatase Inhibitors; Contraceptives, Oral, Synthetic; Drug Therapy, Combination; Female; Humans; Letrozole; Nitriles; Norethindrone; Norethindrone Acetate; Prospective Studies; Rectal Diseases; Triazoles; Vaginal Diseases | 2007 |
Letrozole in advanced breast cancer: the PO25 trial.
Topics: Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Cost-Benefit Analysis; Cross-Over Studies; Disease Progression; Disease-Free Survival; Double-Blind Method; Female; Humans; Letrozole; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Nitriles; Postmenopause; Prognosis; Quality of Life; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles | 2007 |
Relative potencies of anastrozole and letrozole to suppress estradiol in breast cancer patients undergoing ovarian stimulation before in vitro fertilization.
Topics: Adult; Anastrozole; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cryopreservation; Estradiol; Female; Fertilization in Vitro; Follicle Stimulating Hormone; Humans; Letrozole; Luteinizing Hormone; Nitriles; Oocytes; Ovulation Induction; Prospective Studies; Triazoles | 2007 |
The FACE trial: letrozole or anastrozole as initial adjuvant therapy?
Topics: Anastrozole; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Lymphatic Metastasis; Nitriles; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Research Design; Triazoles | 2007 |
Letrozole versus testosterone. a single-center pilot study of HIV-infected men who have sex with men on highly active anti-retroviral therapy (HAART) with hypoactive sexual desire disorder and raised estradiol levels.
Topics: Aged; Antiretroviral Therapy, Highly Active; Aromatase Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Erectile Dysfunction; Estradiol; Homosexuality, Male; Humans; Letrozole; Male; Middle Aged; Nitriles; Pilot Projects; Statistics, Nonparametric; Testosterone; Treatment Outcome; Triazoles | 2007 |
Letrozole treatment of precocious puberty in girls with the McCune-Albright syndrome: a pilot study.
Topics: Antineoplastic Agents; Biomarkers; Bone and Bones; Child; Child, Preschool; Female; Fibrous Dysplasia, Polyostotic; Growth; Humans; Letrozole; Male; Menstruation; Nitriles; Ovarian Cysts; Pilot Projects; Puberty; Puberty, Precocious; Triazoles | 2007 |
Efficacy of letrozole extended adjuvant therapy according to estrogen receptor and progesterone receptor status of the primary tumor: National Cancer Institute of Canada Clinical Trials Group MA.17.
Topics: Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Canada; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Female; Humans; Letrozole; Middle Aged; Nitriles; Placebos; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Retrospective Studies; Survival Rate; Tamoxifen; Treatment Outcome; Triazoles | 2007 |
Management of poor responders: can outcomes be improved with a novel gonadotropin-releasing hormone antagonist/letrozole protocol?
Topics: Adult; Aromatase Inhibitors; Chorionic Gonadotropin; Dose-Response Relationship, Drug; Drug Administration Schedule; Embryo Culture Techniques; Embryo Implantation; Embryo Transfer; Female; Fertility Agents, Female; Fertilization; Fertilization in Vitro; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Humans; Infertility, Female; Letrozole; Leuprolide; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Prospective Studies; Time Factors; Treatment Failure; Treatment Outcome; Triazoles | 2008 |
Randomized controlled trial of three doses of letrozole for ovulation induction in patients with unexplained infertility.
Topics: Adult; Aromatase Inhibitors; Female; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Prospective Studies; Triazoles | 2007 |
Letrozole and desogestrel-only contraceptive pill for the treatment of stage IV endometriosis.
Topics: Adult; Aromatase Inhibitors; Contraceptives, Oral, Synthetic; Desogestrel; Drug Therapy, Combination; Endometriosis; Female; Humans; Letrozole; Nitriles; Ovarian Cysts; Pelvic Pain; Prospective Studies; Triazoles | 2007 |
Molecular response to aromatase inhibitor treatment in primary breast cancer.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Combined Modality Therapy; Female; Gene Expression Regulation, Neoplastic; Humans; Letrozole; Nitriles; Polymerase Chain Reaction; Postmenopause; Receptors, Estrogen; Triazoles; Up-Regulation | 2007 |
Antiestrogen therapy is active in selected ovarian cancer cases: the use of letrozole in estrogen receptor-positive patients.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; CA-125 Antigen; Estrogen Receptor Modulators; Female; Humans; Immunohistochemistry; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Ovarian Neoplasms; Receptors, Estrogen; Triazoles | 2007 |
RETRACTED: Clomiphene citrate or letrozole for ovulation induction in women with polycystic ovarian syndrome: a prospective randomized trial.
Topics: Abortion, Spontaneous; Adult; Aromatase Inhibitors; Clomiphene; Dose-Response Relationship, Drug; Endometrium; Estradiol; Female; Fertility Agents, Female; Humans; Letrozole; Nitriles; Ovarian Follicle; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Progesterone; Prospective Studies; Triazoles | 2009 |
Superiority of gas chromatography/tandem mass spectrometry assay (GC/MS/MS) for estradiol for monitoring of aromatase inhibitor therapy.
Topics: Androstenedione; Aromatase Inhibitors; Biological Assay; Breast Neoplasms; Estradiol; Female; Gas Chromatography-Mass Spectrometry; Humans; Letrozole; Nitriles; Placebos; Postmenopause; Radioimmunoassay; Sensitivity and Specificity; Tandem Mass Spectrometry; Triazoles | 2007 |
Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancer.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Estradiol; Estrogens; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Letrozole; Nitriles; Ovarian Neoplasms; Predictive Value of Tests; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triazoles | 2007 |
Histopathology of breast carcinoma following neoadjuvant systemic therapy: a common association between letrozole therapy and central scarring.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Cicatrix; Female; Humans; Letrozole; Middle Aged; Neoadjuvant Therapy; Nitriles; Receptors, Estrogen; Triazoles | 2007 |
Cost-effectiveness of letrozole versus tamoxifen as initial adjuvant therapy in postmenopausal women with hormone-receptor positive early breast cancer from a Canadian perspective.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Canada; Chemotherapy, Adjuvant; Cost-Benefit Analysis; Drug Costs; Female; Humans; Letrozole; Markov Chains; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Quality-Adjusted Life Years; Tamoxifen; Triazoles | 2008 |
Prognostic and predictive value of centrally reviewed expression of estrogen and progesterone receptors in a randomized trial comparing letrozole and tamoxifen adjuvant therapy for postmenopausal early breast cancer: BIG 1-98.
Topics: Adult; Breast Neoplasms; Disease-Free Survival; Double-Blind Method; Female; Humans; Immunohistochemistry; Letrozole; Nitriles; Postmenopause; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles | 2007 |
RETRACTED: Anastrozole or letrozole for ovulation induction in clomiphene-resistant women with polycystic ovarian syndrome: a prospective randomized trial.
Topics: Abortion, Spontaneous; Adult; Anastrozole; Aromatase Inhibitors; Clomiphene; Drug Resistance; Endometrium; Estradiol; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitriles; Ovarian Follicle; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Progesterone; Prospective Studies; Triazoles | 2008 |
Effects of steroidal and nonsteroidal aromatase inhibitors on markers of bone turnover in healthy postmenopausal women.
Topics: Aged; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers; Bone Density; Bone Remodeling; Bone Resorption; Breast Neoplasms; Estrogens; Female; Humans; Letrozole; Lipids; Menopause; Middle Aged; Nitriles; Peptide Fragments; Placebos; Procollagen; Single-Blind Method; Tamoxifen; Triazoles | 2007 |
Antitumour and biological effects of letrozole and GnRH analogue as primary therapy in premenopausal women with ER and PgR positive locally advanced operable breast cancer.
Topics: Adult; Aged; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Down-Regulation; ErbB Receptors; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Gene Expression Regulation, Neoplastic; Gonadotropin-Releasing Hormone; Humans; Letrozole; Middle Aged; Mitogen-Activated Protein Kinases; Neoplasm Staging; Nitriles; Premenopause; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Time Factors; Treatment Outcome; Triazoles | 2007 |
A phase II, randomized, blinded study of the farnesyltransferase inhibitor tipifarnib combined with letrozole in the treatment of advanced breast cancer after antiestrogen therapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Double-Blind Method; Estrogen Receptor Modulators; Farnesyltranstransferase; Female; Humans; Letrozole; Middle Aged; Nitriles; Quinolones; Time Factors; Treatment Outcome; Triazoles | 2008 |
Changes in breast cancer transcriptional profiles after treatment with the aromatase inhibitor, letrozole.
Topics: Aromatase Inhibitors; Breast Neoplasms; Cluster Analysis; Databases, Nucleic Acid; Female; Gene Expression Regulation, Neoplastic; Genes, Neoplasm; Humans; Letrozole; Nitriles; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Transcription, Genetic; Triazoles | 2007 |
Letrozole as primary therapy for endometrial hyperplasia in young women.
Topics: Adult; Aromatase Inhibitors; Endometrial Hyperplasia; Endometrium; Female; Humans; Letrozole; Nitriles; Pilot Projects; Treatment Outcome; Triazoles | 2008 |
Letrozole in the neoadjuvant setting: the P024 trial.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Double-Blind Method; Female; Humans; Immunohistochemistry; Letrozole; Mastectomy, Segmental; Middle Aged; Neoadjuvant Therapy; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Prognosis; Receptor, ErbB-2; Receptors, Estrogen; Survival Analysis; Tamoxifen; Triazoles | 2007 |
Letrozole in the extended adjuvant setting: MA.17.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Cross-Over Studies; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Nitriles; Quality of Life; Receptors, Estrogen; Tamoxifen; Treatment Outcome; Triazoles | 2007 |
Letrozole as upfront endocrine therapy for postmenopausal women with hormone-sensitive breast cancer: BIG 1-98.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Europe; Female; Humans; Letrozole; Middle Aged; Neoadjuvant Therapy; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles; United States | 2007 |
A decade of letrozole: FACE.
Topics: Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Disease-Free Survival; Estrogen Receptor Modulators; Female; Humans; Letrozole; Lymphatic Metastasis; Middle Aged; Neoadjuvant Therapy; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Receptors, Estrogen; Tamoxifen; Triazoles | 2007 |
Randomized controlled trial comparing superovulation with letrozole versus recombinant follicle-stimulating hormone combined with intrauterine insemination for couples with unexplained infertility who had failed clomiphene citrate stimulation and intraute
Topics: Adult; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Female; Follicle Stimulating Hormone; Humans; Infertility; Insemination, Artificial; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Outcome; Recombinant Proteins; Treatment Failure; Treatment Outcome; Triazoles | 2008 |
Phase III, double-blind, controlled trial of atamestane plus toremifene compared with letrozole in postmenopausal women with advanced receptor-positive breast cancer.
Topics: Aged; Androstenedione; Antineoplastic Agents; Breast Neoplasms; Disease Progression; Double-Blind Method; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Receptors, Steroid; Toremifene; Triazoles | 2007 |
Cardiovascular adverse events during adjuvant endocrine therapy for early breast cancer using letrozole or tamoxifen: safety analysis of BIG 1-98 trial.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cardiovascular Diseases; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Middle Aged; Nitriles; Tamoxifen; Triazoles | 2007 |
Effects of third generation aromatase inhibitors on bone health and other safety parameters: results of an open, randomised, multi-centre study of letrozole, exemestane and anastrozole in healthy postmenopausal women.
Topics: Adrenal Glands; Alkaline Phosphatase; Anastrozole; Androstadienes; Aromatase Inhibitors; Biomarkers; Body Mass Index; Bone and Bones; Bone Remodeling; Bone Resorption; Female; Humans; Letrozole; Lipids; Middle Aged; Nitriles; Postmenopause; Triazoles | 2007 |
The oral mTOR inhibitor RAD001 (everolimus) in combination with letrozole in patients with advanced breast cancer: results of a phase I study with pharmacokinetics.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cohort Studies; Drug Interactions; Everolimus; Feasibility Studies; Female; Humans; Immunosuppressive Agents; Letrozole; Male; Middle Aged; Nitriles; Sirolimus; Treatment Outcome; Triazoles | 2008 |
Effectiveness of cetrorelix for the prevention of premature luteinizing hormone surge during controlled ovarian stimulation using letrozole and gonadotropins: a randomized trial.
Topics: Adult; Aromatase Inhibitors; Chorionic Gonadotropin; Drug Therapy, Combination; Female; Fertility Agents, Female; Fertilization in Vitro; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Gonadotropins; Hormone Antagonists; Humans; Infertility; Letrozole; Luteinizing Hormone; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Prospective Studies; Recombinant Proteins; Taiwan; Treatment Outcome; Triazoles; Up-Regulation | 2008 |
A comparison of letrozole to gonadotropins for ovulation induction in subjects with advanced maternal age: a retrospective pilot study.
Topics: Adult; Aromatase Inhibitors; Female; Gonadotropins; Humans; Infertility, Female; Letrozole; Middle Aged; Nitriles; Ovulation Induction; Pilot Projects; Pregnancy; Pregnancy Rate; Retrospective Studies; Treatment Outcome; Triazoles | 2008 |
Adjuvant letrozole versus tamoxifen according to centrally-assessed ERBB2 status for postmenopausal women with endocrine-responsive early breast cancer: supplementary results from the BIG 1-98 randomised trial.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Female; Follow-Up Studies; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Letrozole; Nitriles; Postmenopause; Receptors, Estrogen; Tamoxifen; Triazoles | 2008 |
Endocrine effects of adjuvant letrozole + triptorelin compared with tamoxifen + triptorelin in premenopausal patients with early breast cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Gonadal Hormones; Humans; Letrozole; Middle Aged; Nitriles; Premenopause; Prospective Studies; Statistics, Nonparametric; Tamoxifen; Treatment Outcome; Triazoles; Triptorelin Pamoate | 2008 |
Comparison of efficacy of aromatase inhibitor and clomiphene citrate in induction of ovulation in polycystic ovarian syndrome.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Dose-Response Relationship, Drug; Endometrium; Female; Fertility Agents, Female; Humans; Letrozole; Nitriles; Ovulation; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Prospective Studies; Treatment Outcome; Triazoles | 2009 |
Effective inhibition of aromatase inhibitor-associated bone loss by zoledronic acid in postmenopausal women with early breast cancer receiving adjuvant letrozole: ZO-FAST Study results.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Bone Density; Bone Density Conservation Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Diphosphonates; Drug Administration Schedule; Female; Humans; Imidazoles; Letrozole; Lumbar Vertebrae; Middle Aged; Nitriles; Osteoporosis, Postmenopausal; Triazoles; Zoledronic Acid | 2008 |
Evaluation of neoadjuvant inhibition of aromatase activity and signal transduction in breast cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Benzamides; Breast Neoplasms; Carcinoma, Ductal, Breast; Chemotherapy, Adjuvant; Drug Evaluation; Female; Humans; Imatinib Mesylate; Letrozole; Middle Aged; Neoadjuvant Therapy; Neoplasms, Hormone-Dependent; Nitriles; Pilot Projects; Piperazines; Postmenopause; Pyrimidines; Signal Transduction; Triazoles | 2008 |
Increase in response rate by prolonged treatment with neoadjuvant letrozole.
Topics: Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Combined Modality Therapy; Disease Progression; Drug Administration Schedule; Female; Humans; Letrozole; Life Expectancy; Mastectomy; Mastectomy, Segmental; Neoadjuvant Therapy; Nitriles; Time Factors; Treatment Outcome; Triazoles | 2009 |
Competing causes of death from a randomized trial of extended adjuvant endocrine therapy for breast cancer.
Topics: Age Factors; Aged; Antineoplastic Agents, Hormonal; Breast Neoplasms; Canada; Cardiovascular Diseases; Cause of Death; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Female; Follow-Up Studies; Humans; Letrozole; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Osteoporosis, Postmenopausal; Prospective Studies; Receptors, Estrogen; Receptors, Progesterone; Research Design; Risk Factors; Triazoles | 2008 |
Neoadjuvant letrozole in postmenopausal estrogen and/or progesterone receptor positive breast cancer: a phase IIb/III trial to investigate optimal duration of preoperative endocrine therapy.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Ductal, Breast; Drug Administration Schedule; Female; Humans; Letrozole; Lymphatic Metastasis; Mammography; Mastectomy; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Nitriles; Postmenopause; Preoperative Care; Receptors, Estrogen; Receptors, Progesterone; Triazoles | 2008 |
Intent-to-treat analysis of the placebo-controlled trial of letrozole for extended adjuvant therapy in early breast cancer: NCIC CTG MA.17.
Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Estrogens; Humans; Kaplan-Meier Estimate; Letrozole; Lymphatic Metastasis; Neoplasms, Hormone-Dependent; Neoplasms, Second Primary; Nitriles; Patient Acceptance of Health Care; Placebos; Postmenopause; Progesterone; Proportional Hazards Models; Recurrence; Tamoxifen; Triazoles | 2008 |
Letrozole compared with tamoxifen for elderly patients with endocrine-responsive early breast cancer: the BIG 1-98 trial.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cardiovascular Diseases; Double-Blind Method; Female; Fractures, Bone; Humans; Letrozole; Middle Aged; Nitriles; Patient Compliance; Postmenopause; Tamoxifen; Triazoles | 2008 |
Efficacy, toxicity, and quality of life in older women with early-stage breast cancer treated with letrozole or placebo after 5 years of tamoxifen: NCIC CTG intergroup trial MA.17.
Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Female; Humans; Letrozole; Middle Aged; Neoplasm Staging; Neoplasms, Hormone-Dependent; Nitriles; Placebos; Quality of Life; Tamoxifen; Triazoles | 2008 |
Late extended adjuvant treatment with letrozole improves outcome in women with early-stage breast cancer who complete 5 years of tamoxifen.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Cohort Studies; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Female; Humans; Letrozole; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Placebos; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles | 2008 |
A comparison of the effects of clomiphene citrate and the aromatase inhibitor letrozole on superovulation in Asian women with normal ovulatory cycles.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Cross-Over Studies; Endometrium; Estradiol; Female; Humans; Letrozole; Nitriles; Ovarian Follicle; Progesterone; Superovulation; Thailand; Triazoles | 2008 |
Letrozole suppresses plasma estradiol and estrone sulphate more completely than anastrozole in postmenopausal women with breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Cross-Over Studies; Estradiol; Estrone; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Radioimmunoassay; Selective Estrogen Receptor Modulators; Tamoxifen; Treatment Outcome; Triazoles | 2008 |
Switching to letrozole or exemestane improves hot flushes, mood and quality of life in tamoxifen intolerant women.
Topics: Affect; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Arthralgia; Breast Neoplasms; Chemotherapy, Adjuvant; Cross-Over Studies; Estrogen Receptor Modulators; Female; Hot Flashes; Humans; Letrozole; Middle Aged; Nitriles; Patient Participation; Patient Selection; Postmenopause; Prospective Studies; Quality of Life; Research Design; Sample Size; Surveys and Questionnaires; Tamoxifen; Triazoles | 2008 |
Letrozole once a week normalizes serum testosterone in obesity-related male hypogonadism.
Topics: Adult; Aromatase Inhibitors; Estradiol; Humans; Hypogonadism; Letrozole; Male; Middle Aged; Nitriles; Obesity; Sex Hormone-Binding Globulin; Testosterone; Triazoles | 2008 |
Comparison of the efficacy of the aromatase inhibitor letrozole and clomiphen citrate gonadotropins in controlled ovarian hyperstimulation: a prospective, simply randomized, clinical trial.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Female; Gonadotropins; Humans; Letrozole; Nitriles; Ovary; Ovulation Induction; Pregnancy; Prospective Studies; Triazoles | 2008 |
A randomised study of the effects of letrozole and anastrozole on oestrogen receptor positive breast cancers in postmenopausal women.
Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; Ki-67 Antigen; Letrozole; Middle Aged; Nitriles; Postmenopause; Receptors, Progesterone; Treatment Outcome; Triazoles | 2009 |
Serum TIMP-1 and response to the aromatase inhibitor letrozole versus tamoxifen in metastatic breast cancer.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Enzyme-Linked Immunosorbent Assay; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Tamoxifen; Tissue Inhibitor of Metalloproteinase-1; Triazoles | 2008 |
Down-regulation of phosphatidylinositol 3'-kinase/AKT/molecular target of rapamycin metabolic pathway by primary letrozole-based therapy in human breast cancer.
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Cyclophosphamide; Down-Regulation; Female; Humans; Letrozole; Nitriles; Phosphatidylinositol 3-Kinases; Protein Kinases; Proto-Oncogene Proteins c-akt; Tissue Array Analysis; TOR Serine-Threonine Kinases; Triazoles | 2008 |
Efficacy of letrozole in the treatment of recurrent platinum- and taxane-resistant high-grade cancer of the ovary or peritoneum.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Cisplatin; Disease Progression; Drug Resistance, Neoplasm; Female; Humans; Letrozole; Middle Aged; Nitriles; Ovarian Neoplasms; Peritoneal Neoplasms; Recurrence; Taxoids; Treatment Outcome; Triazoles | 2008 |
Letrozole versus letrozole plus Lapatinib (GW572016) in hormone-sensitive, HER2-negative operable breast cancer: a double-blind, randomized, phase II study with biomarker evaluation (EGF109077-LAP107692/LETLOB).
Topics: Antineoplastic Agents; Breast Neoplasms; Double-Blind Method; Female; Genes, erbB-2; Humans; Lapatinib; Letrozole; Middle Aged; Neoplasm Staging; Nitriles; Postmenopause; Quinazolines; Treatment Outcome; Triazoles | 2008 |
Safety of fertility preservation by ovarian stimulation with letrozole and gonadotropins in patients with breast cancer: a prospective controlled study.
Topics: Adult; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Counseling; Cryopreservation; Disease-Free Survival; Female; Fertility; Fertilization in Vitro; Gonadotropins; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Ovulation Induction; Prospective Studies; Triazoles | 2008 |
Integrated analysis of zoledronic acid for prevention of aromatase inhibitor-associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole.
Topics: Adult; Aged; Aged, 80 and over; Aromatase Inhibitors; Bone Density; Bone Density Conservation Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Diphosphonates; Drug Administration Schedule; Female; Humans; Imidazoles; Letrozole; Lumbar Vertebrae; Middle Aged; Nitriles; Osteoporosis, Postmenopausal; Triazoles; Zoledronic Acid | 2008 |
Endometrial effects of letrozole and clomiphene citrate in women with polycystic ovary syndrome using spiral artery Doppler.
Topics: Adult; Clomiphene; Endometrium; Female; Fertility Agents, Female; Humans; Letrozole; Nitriles; Ovarian Follicle; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Prospective Studies; Triazoles; Ultrasonography, Doppler, Color | 2009 |
Effects of testosterone undecanoate administered alone or in combination with letrozole or dutasteride in female to male transsexuals.
Topics: Adolescent; Adult; Aromatase Inhibitors; Azasteroids; Dihydrotestosterone; Drug Therapy, Combination; Dutasteride; Enzyme Inhibitors; Estradiol; Female; Follicle Stimulating Hormone; Humans; Letrozole; Luteinizing Hormone; Male; Middle Aged; Nitriles; Sex Hormone-Binding Globulin; Testosterone; Transsexualism; Triazoles; Young Adult | 2008 |
A phase I and pharmacokinetic study of lapatinib in combination with letrozole in patients with advanced cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Breast Neoplasms; Female; Humans; Lapatinib; Letrozole; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Nitriles; Ovarian Neoplasms; Quinazolines; Triazoles | 2008 |
RETRACTED: Clomiphene citrate or aromatase inhibitors for superovulation in women with unexplained infertility undergoing intrauterine insemination: a prospective randomized trial.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Insemination, Artificial; Letrozole; Nitriles; Pregnancy; Pregnancy, Multiple; Superovulation; Treatment Outcome; Triazoles; Twins | 2009 |
Extended letrozole therapy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a novel protocol.
Topics: Adult; Anovulation; Aromatase Inhibitors; Clomiphene; Drug Resistance; Estrogen Antagonists; Female; Humans; Hyperandrogenism; Letrozole; Nitriles; Ovarian Follicle; Ovulation Induction; Parity; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Outcome; Prospective Studies; Treatment Failure; Treatment Outcome; Triazoles; Young Adult | 2009 |
Letrozole administration during the luteal phase after ovarian stimulation impacts corpus luteum function: a randomized, placebo-controlled trial.
Topics: Aromatase Inhibitors; Corpus Luteum; Estradiol; Female; Humans; Intrauterine Devices; Letrozole; Luteal Phase; Luteinizing Hormone; Nitriles; Oocyte Donation; Oocyte Retrieval; Placebos; Progesterone; Tissue Donors; Triazoles | 2009 |
Luteal phase oestradiol suppression by letrozole: a pilot study in oocyte donors.
Topics: Adult; Estradiol; Estrogen Antagonists; Female; Fertilization in Vitro; Humans; Letrozole; Luteal Phase; Luteinizing Hormone; Nitriles; Oocyte Donation; Pilot Projects; Progesterone; Triazoles | 2008 |
Bioequivalence study of two letrozole tablet formulations. Single dose, randomized, open-label, two-way crossover bioequivalence study of letrozole 2.5 mg tablets in healthy volunteers under fasting conditions.
Topics: Adult; Aged; Antineoplastic Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Chemistry, Pharmaceutical; Cross-Over Studies; Cytochrome P-450 CYP2A6; Double-Blind Method; Fasting; Female; Humans; Letrozole; Linear Models; Middle Aged; Nitriles; Tablets; Triazoles | 2008 |
Letrozole is superior to anastrozole in suppressing breast cancer tissue and plasma estrogen levels.
Topics: Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents; Breast Neoplasms; Chromatography, High Pressure Liquid; Estradiol; Estrogens; Estrone; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Radioimmunoassay; Triazoles | 2008 |
Treatment of symptomatic uterine leiomyoma with letrozole.
Topics: Adult; Antineoplastic Agents; Aromatase Inhibitors; Bone and Bones; Bone Density; Female; Follicle Stimulating Hormone; Humans; Leiomyoma; Letrozole; Luteinizing Hormone; Nitriles; Organ Size; Ovary; Pilot Projects; Triazoles; Tumor Burden; Uterine Neoplasms; Uterus | 2008 |
Aromatase expression and outcomes in the P024 neoadjuvant endocrine therapy trial.
Topics: Aged; Antineoplastic Agents, Hormonal; Aromatase; Biomarkers, Tumor; Breast Neoplasms; Disease-Free Survival; Double-Blind Method; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Ki-67 Antigen; Letrozole; Neoadjuvant Therapy; Nitriles; Prognosis; Receptors, Estrogen; Tamoxifen; Treatment Outcome; Triazoles | 2009 |
Aromatase inhibitors prevent the estrogen rise associated with the flare effect of gonadotropins in patients treated with GnRH agonists.
Topics: Adult; Aromatase Inhibitors; Endometriosis; Estrogens; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Humans; Leiomyoma; Letrozole; Leuprolide; Luteinizing Hormone; Nitriles; Progesterone; Triazoles | 2009 |
Prognostic and predictive value of centrally reviewed Ki-67 labeling index in postmenopausal women with endocrine-responsive breast cancer: results from Breast International Group Trial 1-98 comparing adjuvant tamoxifen with letrozole.
Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chemotherapy, Adjuvant; Cohort Studies; Endocrine System; Female; Humans; Ki-67 Antigen; Letrozole; Nitriles; Postmenopause; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Tamoxifen; Triazoles | 2008 |
Comparison of endocrine and ultrasound profiles during ovulation induction with clomiphene citrate and letrozole in ovulatory volunteer women.
Topics: Adult; Biomarkers; Clomiphene; Cross-Over Studies; Double-Blind Method; Endometrium; Estradiol; Female; Fertility Agents, Female; Follicular Phase; Hormones; Humans; Letrozole; Luteinizing Hormone; Nitriles; Oocyte Donation; Ovarian Follicle; Ovulation; Ovulation Induction; Prospective Studies; Testosterone; Time Factors; Triazoles; Ultrasonography; Young Adult | 2010 |
Short-term aromatase inhibition: effects on glucose metabolism and serum leptin levels in young and elderly men.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Aromatase; Aromatase Inhibitors; Blood Glucose; Cross-Over Studies; Estradiol; Humans; Insulin; Insulin-Like Growth Factor I; Leptin; Letrozole; Luteinizing Hormone; Male; Nitriles; Placebos; Testosterone; Triazoles; Young Adult | 2009 |
Phosphorylated ERalpha, HIF-1alpha, and MAPK signaling as predictors of primary endocrine treatment response and resistance in patients with breast cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Aromatase Inhibitors; Breast Neoplasms; Cell Growth Processes; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Cyclophosphamide; Drug Administration Schedule; Estrogen Receptor alpha; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Ki-67 Antigen; Letrozole; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Neoadjuvant Therapy; Nitriles; Phosphorylation; Triazoles | 2009 |
Pregnancy outcome after ovulation induction with aromatase inhibitors or clomiphene citrate in unexplained infertility.
Topics: Abortion, Spontaneous; Adult; Anastrozole; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Female; Humans; Infant, Newborn; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Outcome; Triazoles | 2009 |
Endometrial and follicular development following letrozole intervention in unexplained infertile patients failed to get pregnant with clomiphene citrate.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Endometrium; Estradiol; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Luteinizing Hormone; Nitriles; Ovarian Follicle; Prospective Studies; Triazoles | 2009 |
Digital image analysis of breast epithelial cells collected by random periareolar fine-needle aspirates (RPFNA) from women at high risk for breast cancer taking hormone replacement and the aromatase inhibitor, letrozole, for six months.
Topics: Aromatase Inhibitors; Biopsy, Fine-Needle; Breast Neoplasms; Cell Nucleus; Clinical Trials, Phase II as Topic; Epithelial Cells; Female; Follow-Up Studies; Humans; Image Processing, Computer-Assisted; Ki-67 Antigen; Letrozole; Mammography; Menopause; Nitriles; Pilot Projects; Predictive Value of Tests; Risk Factors; Treatment Outcome; Triazoles | 2009 |
Comparison of letrozole with continuous gonadotropins and clomiphene-gonadotropin combination for ovulation induction in 1387 PCOS women after clomiphene citrate failure: a randomized prospective clinical trial.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Therapy, Combination; Estradiol; Female; Fertility Agents, Female; Follicle Stimulating Hormone, Human; Humans; Infertility; Letrozole; Male; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Single-Blind Method; Triazoles | 2009 |
A randomized, controlled clinical trial comparing the effects of aromatase inhibitor (letrozole) and gonadotropin-releasing hormone agonist (triptorelin) on uterine leiomyoma volume and hormonal status.
Topics: Adult; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Estradiol; Female; Follicle Stimulating Hormone, Human; Germany; Gonadotropin-Releasing Hormone; Hormones; Hospitals, University; Hot Flashes; Humans; Iran; Leiomyoma; Letrozole; Luteinizing Hormone; Nitriles; Prospective Studies; Testosterone; Time Factors; Treatment Outcome; Triazoles; Triptorelin Pamoate; Tumor Burden; Uterine Neoplasms | 2010 |
Immediate versus delayed zoledronic acid for prevention of bone loss in postmenopausal women with breast cancer starting letrozole after tamoxifen-N03CC.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Bone Density; Bone Density Conservation Agents; Breast Neoplasms; Diphosphonates; Drug Administration Schedule; Female; Humans; Imidazoles; Letrozole; Middle Aged; Nitriles; Osteoporosis, Postmenopausal; Tamoxifen; Triazoles; Zoledronic Acid | 2009 |
Bone Quality Test (BQT) scores of fingernails in postmenopausal patients treated with adjuvant letrozole or tamoxifen for early breast cancer.
Topics: Aged; Antineoplastic Agents, Hormonal; Bone Density; Breast Neoplasms; Female; Humans; Letrozole; Middle Aged; Nails; Nitriles; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles | 2009 |
Impact of aromatase inhibitor therapy on bone turnover, cortical bone growth and vertebral morphology in pre- and peripubertal boys with idiopathic short stature.
Topics: Absorptiometry, Photon; Adolescent; Aromatase Inhibitors; Bone and Bones; Bone Density; Bone Development; Child; Collagen Type I; Estradiol; Fetal Proteins; Growth Disorders; Humans; Insulin-Like Growth Factor I; Letrozole; Male; Nitriles; Peptide Fragments; Peptides; Placebos; Procollagen; Testosterone; Triazoles | 2009 |
[Lipid metabolism disorders at the breast cancer patients receiving hormonotherapy].
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Cholesterol, LDL; Dyslipidemias; Estrogen Antagonists; Female; Humans; Letrozole; Lipid Metabolism Disorders; Nitriles; Tamoxifen; Time Factors; Toremifene; Triazoles; Triglycerides | 2009 |
Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Biomarkers, Tumor; Biopsy; Breast Neoplasms; Cell Proliferation; Chemotherapy, Adjuvant; Class I Phosphatidylinositol 3-Kinases; Cyclin D1; Double-Blind Method; Europe; Everolimus; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Ki-67 Antigen; Letrozole; Middle Aged; Mutation; Neoadjuvant Therapy; Nitriles; Palpation; Phosphatidylinositol 3-Kinases; Phosphorylation; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Ribosomal Protein S6 Kinases; Sirolimus; Time Factors; Treatment Outcome; Triazoles; United States | 2009 |
Endocrine effects of adjuvant letrozole compared with tamoxifen in hormone-responsive postmenopausal patients with early breast cancer: the HOBOE trial.
Topics: Aged; Antineoplastic Agents; Bone Density Conservation Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Dehydroepiandrosterone Sulfate; Diphosphonates; Estradiol; Female; Follicle Stimulating Hormone; Humans; Hydrocortisone; Imidazoles; Letrozole; Luteinizing Hormone; Middle Aged; Nitriles; Postmenopause; Progesterone; Receptors, Estrogen; Tamoxifen; Testosterone; Triazoles; Zoledronic Acid | 2009 |
Zoledronic acid effectively prevents aromatase inhibitor-associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole: Z-FAST study 36-month follow-up results.
Topics: Adult; Aged; Aged, 80 and over; Aromatase Inhibitors; Bone Density; Bone Density Conservation Agents; Breast Neoplasms; Diphosphonates; Female; Follow-Up Studies; Humans; Imidazoles; Letrozole; Middle Aged; Neoplasm Staging; Nitriles; Osteoporosis, Postmenopausal; Prognosis; Survival Rate; Treatment Outcome; Triazoles; Zoledronic Acid | 2009 |
Bone fractures among postmenopausal patients with endocrine-responsive early breast cancer treated with 5 years of letrozole or tamoxifen in the BIG 1-98 trial.
Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Double-Blind Method; Female; Fractures, Bone; Humans; Incidence; Letrozole; Middle Aged; Nitriles; Postmenopause; Risk Factors; Tamoxifen; Triazoles | 2009 |
Improved surgical outcomes for breast cancer patients receiving neoadjuvant aromatase inhibitor therapy: results from a multicenter phase II trial.
Topics: Aged; Aged, 80 and over; Aromatase Inhibitors; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Mastectomy, Segmental; Middle Aged; Multivariate Analysis; Neoadjuvant Therapy; Neoplasm Staging; Nitriles; Treatment Outcome; Triazoles | 2009 |
Design, conduct, and analyses of Breast International Group (BIG) 1-98: a randomized, double-blind, phase-III study comparing letrozole and tamoxifen as adjuvant endocrine therapy for postmenopausal women with receptor-positive, early breast cancer.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Chemotherapy, Adjuvant; Double-Blind Method; Drug Therapy, Combination; Estrogen Antagonists; Female; Humans; Letrozole; Nitriles; Postmenopause; Receptors, Estrogen; Research Design; Tamoxifen; Treatment Outcome; Triazoles | 2009 |
In situ aromatase expression in primary tumor is associated with estrogen receptor expression but is not predictive of response to endocrine therapy in advanced breast cancer.
Topics: Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Carcinoma in Situ; Cyclooxygenase 2; Female; Humans; Immunohistochemistry; Letrozole; Nitriles; Receptors, Estrogen; Receptors, Progesterone; Retrospective Studies; Tamoxifen; Tissue Array Analysis; Triazoles | 2009 |
Pathologic and biologic response to preoperative endocrine therapy in patients with ER-positive ductal carcinoma in situ.
Topics: Adult; Aged; Breast Neoplasms; Carcinoma, Ductal; Cohort Studies; Estrogen Antagonists; Female; Gene Expression Regulation, Neoplastic; Hormone Replacement Therapy; Humans; Letrozole; Middle Aged; Nitriles; Receptors, Estrogen; Tamoxifen; Triazoles | 2009 |
Letrozole therapy alone or in sequence with tamoxifen in women with breast cancer.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Fractures, Bone; Humans; Incidence; Kaplan-Meier Estimate; Letrozole; Neoplasm Recurrence, Local; Nitriles; Postmenopause; Proportional Hazards Models; Tamoxifen; Triazoles | 2009 |
Letrozole combined with norethisterone acetate compared with norethisterone acetate alone in the treatment of pain symptoms caused by endometriosis.
Topics: Adult; Analgesics, Non-Narcotic; Aromatase Inhibitors; Drug Therapy, Combination; Dysmenorrhea; Dyspareunia; Endometriosis; Female; Humans; Letrozole; Nitriles; Norethindrone; Norethindrone Acetate; Pain Measurement; Patient Satisfaction; Pelvic Pain; Prospective Studies; Time Factors; Treatment Outcome; Triazoles; Young Adult | 2009 |
RETRACTED: Letrozole versus combined metformin and clomiphene citrate for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized controlled trial.
Topics: Adult; Algorithms; Clomiphene; Drug Combinations; Drug Resistance; Female; Fertility Agents, Female; Humans; Hypoglycemic Agents; Infertility, Female; Letrozole; Metformin; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Treatment Outcome; Triazoles; Young Adult | 2010 |
Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Carcinoma; Disease-Free Survival; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Kaplan-Meier Estimate; Lapatinib; Letrozole; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Nitriles; Postmenopause; Prognosis; Proportional Hazards Models; Quinazolines; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Risk Assessment; Survival Analysis; Treatment Outcome; Triazoles | 2009 |
Use of aromatase inhibitors in poor-responder patients receiving GnRH antagonist protocols.
Topics: Adult; Aromatase Inhibitors; Chorionic Gonadotropin; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Sperm Injections, Intracytoplasmic; Treatment Outcome; Triazoles | 2009 |
Update of the BIG 1-98 Trial: where do we stand?
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Letrozole; Nitriles; Postmenopause; Proportional Hazards Models; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles | 2009 |
A study of the effects of the aromatase inhibitors anastrozole and letrozole on bone metabolism in postmenopausal women with estrogen receptor-positive breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Aromatase Inhibitors; Bone and Bones; Bone Resorption; Breast Neoplasms; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles | 2010 |
A randomized, placebo-controlled trial (NCIC CTG MAP1) examining the effects of letrozole on mammographic breast density and other end organs in postmenopausal women.
Topics: Antineoplastic Agents; Bone Density; Breast; Breast Neoplasms; Double-Blind Method; Female; Humans; Insulin-Like Growth Factor I; Letrozole; Lipids; Mammography; Middle Aged; Nitriles; Postmenopause; Triazoles | 2010 |
Effect of a switch of aromatase inhibitors on musculoskeletal symptoms in postmenopausal women with hormone-receptor-positive breast cancer: the ATOLL (articular tolerance of letrozole) study.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Middle Aged; Musculoskeletal Diseases; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Triazoles | 2010 |
Zoledronic acid for treatment of osteopenia and osteoporosis in women with primary breast cancer undergoing adjuvant aromatase inhibitor therapy.
Topics: Aromatase Inhibitors; Bone Density; Bone Density Conservation Agents; Bone Diseases, Metabolic; Breast Neoplasms; Chemotherapy, Adjuvant; Diphosphonates; Female; Humans; Imidazoles; Letrozole; Nitriles; Osteoporosis; Risk Factors; Treatment Outcome; Triazoles; Zoledronic Acid | 2010 |
Concurrent or sequential adjuvant letrozole and radiotherapy after conservative surgery for early-stage breast cancer (CO-HO-RT): a phase 2 randomised trial.
Topics: Aged; Aged, 80 and over; Aromatase Inhibitors; Breast Neoplasms; Combined Modality Therapy; Dermatitis; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Radiation-Sensitizing Agents; Survival Analysis; Triazoles | 2010 |
Lapatinib plus letrozole as first-line therapy for HER-2+ hormone receptor-positive metastatic breast cancer.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Disease-Free Survival; Double-Blind Method; Drug Synergism; Female; Humans; Lapatinib; Letrozole; Middle Aged; Nitriles; Placebos; Postmenopause; Quinazolines; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Treatment Outcome; Triazoles | 2010 |
Vertebral morphology in aromatase inhibitor-treated males with idiopathic short stature or constitutional delay of puberty.
Topics: Adolescent; Aromatase Inhibitors; Child; Growth Disorders; Humans; Letrozole; Magnetic Resonance Imaging; Male; Nitriles; Puberty; Puberty, Delayed; Spine; Testosterone; Triazoles | 2010 |
Cognitive function in postmenopausal women receiving adjuvant letrozole or tamoxifen for breast cancer in the BIG 1-98 randomized trial.
Topics: Aged; Analysis of Variance; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Cognition; Double-Blind Method; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Statistics, Nonparametric; Tamoxifen; Triazoles | 2010 |
Cognitive effects of aromatase inhibitor therapy in peripubertal boys.
Topics: Adolescent; Aromatase Inhibitors; Child; Cognition; Double-Blind Method; Growth Disorders; Humans; Letrozole; Male; Nitriles; Triazoles | 2010 |
Phase II parallel group study showing comparable efficacy between premenopausal metastatic breast cancer patients treated with letrozole plus goserelin and postmenopausal patients treated with letrozole alone as first-line hormone therapy.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Biopsy, Needle; Bone Density; Breast Neoplasms; Disease Progression; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Goserelin; Humans; Immunohistochemistry; Injections, Subcutaneous; Kaplan-Meier Estimate; Letrozole; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Staging; Nitriles; Postmenopause; Premenopause; Probability; Prognosis; Proportional Hazards Models; Risk Assessment; Statistics, Nonparametric; Survival Analysis; Treatment Outcome; Triazoles | 2010 |
Efficacy of zoledronic acid in postmenopausal women with early breast cancer receiving adjuvant letrozole: 36-month results of the ZO-FAST Study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Density Conservation Agents; Bone Resorption; Breast Neoplasms; Chemotherapy, Adjuvant; Diphosphonates; Drug Therapy, Combination; Female; Humans; Imidazoles; Letrozole; Neoplasm Recurrence, Local; Neoplasm Staging; Nitriles; Postmenopause; Survival Rate; Time Factors; Treatment Outcome; Triazoles; Zoledronic Acid | 2010 |
Effects of estrogen and testosterone on resting energy expenditure in older men.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Basal Metabolism; Calorimetry, Indirect; Carbon Dioxide; Estrogens; Humans; Letrozole; Leuprolide; Male; Middle Aged; Nitriles; Oxygen Consumption; Testosterone; Triazoles | 2010 |
The influence of high-normal testosterone levels on risk-taking in healthy males in a 1-week letrozole administration study.
Topics: Adult; Aromatase Inhibitors; Decision Making; Double-Blind Method; Drug Administration Schedule; Gambling; Health; Humans; Letrozole; Male; Nitriles; Risk-Taking; Task Performance and Analysis; Testosterone; Time Factors; Triazoles; Young Adult | 2010 |
Sex steroids affect triglyceride handling, glucose-dependent insulinotropic polypeptide, and insulin sensitivity: a 1-week randomized clinical trial in healthy young men.
Topics: Adult; Aromatase Inhibitors; Estradiol; Fasting; Gastric Inhibitory Polypeptide; Humans; Insulin Resistance; Letrozole; Lipid Metabolism; Male; Nitriles; Postprandial Period; Testosterone; Triazoles; Triglycerides; Young Adult | 2010 |
Letrozole versus laparoscopic ovarian diathermy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized controlled trial.
Topics: Adult; Aromatase Inhibitors; Diathermy; Female; Humans; Letrozole; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Prospective Studies; Triazoles | 2010 |
Early metabolic response to neoadjuvant letrozole, measured by FDG PET/CT, is correlated with a decrease in the Ki67 labeling index in patients with hormone receptor-positive primary breast cancer: a pilot study.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Drug Administration Schedule; Feasibility Studies; Female; Fluorodeoxyglucose F18; Humans; Ki-67 Antigen; Letrozole; Middle Aged; Multimodal Imaging; Neoadjuvant Therapy; Nitriles; Pilot Projects; Positron-Emission Tomography; Postmenopause; Prospective Studies; Radiopharmaceuticals; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Tomography, X-Ray Computed; Treatment Outcome; Triazoles | 2011 |
A double-blind, placebo-controlled comparison of letrozole to oxandrolone effects upon growth and puberty of children with constitutional delay of puberty and idiopathic short stature.
Topics: Adolescent; Androgens; Aromatase Inhibitors; Body Height; Bone Density; Cholesterol; Double-Blind Method; Female; Growth Disorders; Humans; Insulin-Like Growth Factor I; Letrozole; Male; Nitriles; Oxandrolone; Prospective Studies; Puberty, Delayed; Statistics, Nonparametric; Testosterone; Triazoles; Triglycerides | 2010 |
Aromatase inhibitors in women with clomiphene citrate resistance: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Double-Blind Method; Drug Resistance; Female; Fertility Agents, Female; Humans; Infant, Newborn; Infertility, Female; Letrozole; Nitriles; Ovulation; Pregnancy; Pregnancy Rate; Treatment Failure; Triazoles; Young Adult | 2010 |
Changes in expression of oestrogen regulated and proliferation genes with neoadjuvant treatment highlight heterogeneity of clinical resistance to the aromatase inhibitor, letrozole.
Topics: Aged; Aged, 80 and over; Aromatase Inhibitors; Breast Neoplasms; Cell Proliferation; Drug Resistance, Neoplasm; Estrogens; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic Heterogeneity; Humans; Letrozole; Middle Aged; Neoadjuvant Therapy; Nitriles; Oligonucleotide Array Sequence Analysis; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; Treatment Outcome; Triazoles | 2010 |
A comparison of the effect of short-term aromatase inhibitor (letrozole) and GnRH agonist (triptorelin) versus case control on pregnancy rate and symptom and sign recurrence after laparoscopic treatment of endometriosis.
Topics: Adult; Aromatase Inhibitors; Endometriosis; Female; Gonadotropin-Releasing Hormone; Humans; Infertility, Female; Laparoscopy; Letrozole; Nitriles; Postoperative Period; Pregnancy; Pregnancy Rate; Prospective Studies; Secondary Prevention; Triazoles; Triptorelin Pamoate | 2011 |
Clomiphene citrate or aromatase inhibitors combined with gonadotropins for superovulation in women undergoing intrauterine insemination: a prospective randomised trial.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Therapy, Combination; Female; Follicle Stimulating Hormone; Humans; Insemination, Artificial; Letrozole; Nitriles; Ovary; Pregnancy; Superovulation; Treatment Outcome; Triazoles | 2010 |
Pilot trial of preoperative (neoadjuvant) letrozole in combination with bevacizumab in postmenopausal women with newly diagnosed estrogen receptor- or progesterone receptor-positive breast cancer.
Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Breast Neoplasms; Female; Humans; Letrozole; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Nitriles; Pilot Projects; Positron-Emission Tomography; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Triazoles | 2010 |
Quality of life in hormone receptor-positive HER-2+ metastatic breast cancer patients during treatment with letrozole alone or in combination with lapatinib.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Disease-Free Survival; Double-Blind Method; Female; Humans; Lapatinib; Letrozole; Nitriles; Quality of Life; Quinazolines; Receptor, ErbB-2; Triazoles | 2010 |
Anastrozole and letrozole: an investigation and comparison of quality of life and tolerability.
Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cross-Over Studies; Endocrine System; Humans; Letrozole; Middle Aged; Nitriles; Quality of Life; Tamoxifen; Treatment Outcome; Triazoles | 2011 |
The effect of aromatase inhibitor letrozole on body mass index, serum hormones, and sperm parameters in infertile men.
Topics: Adult; Aromatase Inhibitors; Body Mass Index; Estradiol; Hormones; Humans; Infertility, Male; Letrozole; Male; Middle Aged; Nitriles; Semen Analysis; Spermatozoa; Testosterone; Triazoles | 2011 |
Cognitive function in postmenopausal breast cancer patients one year after completing adjuvant endocrine therapy with letrozole and/or tamoxifen in the BIG 1-98 trial.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cognition; Cross-Sectional Studies; Female; Humans; International Agencies; Letrozole; Longitudinal Studies; Menopause; Nitriles; Prognosis; Survival Rate; Tamoxifen; Triazoles | 2011 |
GnRH antagonist/letrozole versus microdose GnRH agonist flare protocol in poor responders undergoing in vitro fertilization.
Topics: Adult; Aromatase Inhibitors; Contraceptives, Oral; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone; Humans; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Prospective Studies; Triazoles | 2010 |
A pilot study on the use of letrozole with either misoprostol or mifepristone for termination of pregnancy up to 63 days.
Topics: Abortifacient Agents; Abortion, Induced; Adolescent; Adult; Estradiol; Female; Humans; Hydrocortisone; Letrozole; Mifepristone; Misoprostol; Nitriles; Pilot Projects; Pregnancy; Pregnancy Trimester, First; Progesterone; Triazoles; Young Adult | 2011 |
Misoprostol with or without letrozole pretreatment for termination of pregnancy: a randomized controlled trial.
Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Adult; Aromatase Inhibitors; Double-Blind Method; Female; Humans; Letrozole; Misoprostol; Nitriles; Pregnancy; Pregnancy Trimester, First; Treatment Outcome; Triazoles; Young Adult | 2011 |
Combination of trastuzumab and letrozole after resistance to sequential trastuzumab and aromatase inhibitor monotherapies in patients with estrogen receptor-positive, HER-2-positive advanced breast cancer: a proof-of-concept trial (SAKK 23/03).
Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Drug Combinations; Drug Resistance, Neoplasm; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Receptor, ErbB-2; Receptors, Estrogen; Trastuzumab; Treatment Outcome; Triazoles | 2011 |
Analyses adjusting for selective crossover show improved overall survival with adjuvant letrozole compared with tamoxifen in the BIG 1-98 study.
Topics: Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Cross-Over Studies; Double-Blind Method; Female; Follow-Up Studies; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Receptors, Estrogen; Receptors, Progesterone; Survival Rate; Tamoxifen; Treatment Outcome; Triazoles | 2011 |
Which patients benefit most from adjuvant aromatase inhibitors? Results using a composite measure of prognostic risk in the BIG 1-98 randomized trial.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Double-Blind Method; Drug Administration Schedule; ErbB Receptors; Female; Humans; Ki-67 Antigen; Letrozole; Middle Aged; Nitriles; Prognosis; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles | 2011 |
Aromatase inhibition causes increased amplitude, but not frequency, of hypothalamic-pituitary output in normal women.
Topics: Adolescent; Adult; Aromatase; Aromatase Inhibitors; Drug Administration Schedule; Estradiol; Female; Follicle Stimulating Hormone; Humans; Hypothalamus; Letrozole; Luteinizing Hormone; Nitriles; Pituitary Gland; Pulsatile Flow; Triazoles; Young Adult | 2011 |
Reproductive outcome after letrozole versus laparoscopic ovarian drilling for clomiphene-resistant polycystic ovary syndrome.
Topics: Adult; Anovulation; Aromatase Inhibitors; Clomiphene; Drug Administration Schedule; Drug Resistance; Female; Fertility Agents, Female; Humans; Infertility, Female; Laparoscopy; Letrozole; Nitriles; Polycystic Ovary Syndrome; Pregnancy; Reproduction; Treatment Outcome; Triazoles | 2011 |
Population pharmacokinetic analysis of letrozole in Japanese postmenopausal women.
Topics: Aged; Antineoplastic Agents; Aromatase Inhibitors; Aryl Hydrocarbon Hydroxylases; Asian People; Bilirubin; Body Weight; Creatinine; Cytochrome P-450 CYP2A6; Estradiol; Estrone; Female; Genotype; Humans; Letrozole; Nitriles; Polymorphism, Genetic; Postmenopause; Triazoles | 2011 |
Randomized phase II neoadjuvant comparison between letrozole, anastrozole, and exemestane for postmenopausal women with estrogen receptor-rich stage 2 to 3 breast cancer: clinical and biomarker outcomes and predictive value of the baseline PAM50-based int
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Female; Humans; Ki-67 Antigen; Letrozole; Neoadjuvant Therapy; Neoplasm Staging; Nitriles; Postmenopause; Prognosis; Receptors, Estrogen; Triazoles | 2011 |
Androgens and musculoskeletal symptoms among breast cancer patients on aromatase inhibitor therapy.
Topics: Aged; Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Dehydroepiandrosterone Sulfate; Female; Humans; Letrozole; Middle Aged; Musculoskeletal Pain; Nitriles; Testosterone; Triazoles | 2011 |
Extended letrozole regimen versus clomiphene citrate for superovulation in patients with unexplained infertility undergoing intrauterine insemination: a randomized controlled trial.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Female; Humans; Infertility, Female; Insemination; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Receptors, Estrogen; Superovulation; Triazoles | 2011 |
Letrozole and norethisterone acetate versus letrozole and triptorelin in the treatment of endometriosis related pain symptoms: a randomized controlled trial.
Topics: Adult; Aromatase Inhibitors; Drug Therapy, Combination; Dyspareunia; Endometriosis; Female; Humans; Letrozole; Nitriles; Norethindrone; Norethindrone Acetate; Patient Satisfaction; Pelvic Pain; Triazoles; Triptorelin Pamoate; Ultrasonography | 2011 |
Extended high dose letrozole regimen versus short low dose letrozole regimen as an adjuvant to gonadotropin releasing hormone antagonist protocol in poor responders undergoing IVF-ET.
Topics: Adjuvants, Pharmaceutic; Adult; Cost-Benefit Analysis; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance; Embryo Transfer; Female; Fertility Agents, Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone; Hormone Antagonists; Humans; Letrozole; Male; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Treatment Failure; Triazoles | 2011 |
A randomized trial of ovulation induction with two different doses of Letrozole in women with PCOS.
Topics: Adult; Coitus; Drug Administration Schedule; Female; Fertility Agents, Female; Humans; Letrozole; Menstrual Cycle; Nitriles; Ovarian Follicle; Ovulation Induction; Pregnancy; Pregnancy Rate; Prospective Studies; Treatment Outcome; Triazoles | 2011 |
Increased 5α-reductase type 2 expression in human breast carcinoma following aromatase inhibitor therapy: the correlation with decreased tumor cell proliferation.
Topics: 17-Hydroxysteroid Dehydrogenases; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androstadienes; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Carcinoma, Ductal, Breast; Celecoxib; Cell Proliferation; Female; Humans; Immunohistochemistry; Letrozole; Neoadjuvant Therapy; Nitriles; Pyrazoles; Receptors, Androgen; Sulfonamides; Treatment Outcome; Triazoles | 2011 |
Sequential use of letrozole and gonadotrophin in women with poor ovarian reserve: a randomized controlled trial.
Topics: Adult; Androstenedione; Anti-Mullerian Hormone; Aromatase Inhibitors; Estradiol; Female; Fertilization in Vitro; Follicle Stimulating Hormone; Follicular Fluid; Humans; Letrozole; Menotropins; Nitriles; Ovarian Follicle; Pregnancy; Pregnancy Rate; Triazoles | 2011 |
Estimating rates of multiple gestation pregnancies: sample size calculation from the assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trial.
Topics: Adolescent; Adult; Aromatase Inhibitors; Clomiphene; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fertility Agents, Female; Gonadotropins; Humans; Infant, Newborn; Infertility; Letrozole; Male; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Outcome; Pregnancy, Multiple; Prospective Studies; Treatment Outcome; Triazoles; Young Adult | 2011 |
Clomiphene citrate versus letrozole: molecular analysis of the endometrium in women with polycystic ovary syndrome.
Topics: Adult; Clomiphene; Endometrium; Female; Fertility Agents, Female; Gene Expression Regulation; Humans; Letrozole; Leukemia Inhibitory Factor; Nitriles; Polycystic Ovary Syndrome; Receptors, OSM-LIF; Triazoles | 2011 |
Higher efficacy of letrozole in combination with trastuzumab compared to letrozole monotherapy as first-line treatment in patients with HER2-positive, hormone-receptor-positive metastatic breast cancer - results of the eLEcTRA trial.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Drug Therapy, Combination; Female; Humans; Letrozole; Middle Aged; Nitriles; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Trastuzumab; Treatment Outcome; Triazoles | 2012 |
Invasive lobular carcinoma: response to neoadjuvant letrozole therapy.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Lobular; Female; Humans; Letrozole; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Nitriles; Postmenopause; Treatment Outcome; Triazoles | 2011 |
Randomized phase II trial of letrozole plus anti-MUC1 antibody AS1402 in hormone receptor-positive locally advanced or metastatic breast cancer.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Drug Administration Schedule; Female; Humans; Immunoglobulin Allotypes; Letrozole; Middle Aged; Mucin-1; Neoplasm Metastasis; Neoplasm Staging; Nitriles; Receptors, Estrogen; Receptors, IgG; Receptors, Progesterone; Triazoles | 2011 |
The advantage of letrozole over tamoxifen in the BIG 1-98 trial is consistent in younger postmenopausal women and in those with chemotherapy-induced menopause.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Disease-Free Survival; Double-Blind Method; Female; Humans; Letrozole; Menopause; Middle Aged; Nitriles; Postmenopause; Tamoxifen; Triazoles | 2012 |
[Letrozole vs. tamoxifen as neoadjuvant therapy for postmenopausal patients with hormone-dependent locally-advanced breast cancer].
Topics: Aged; Antineoplastic Agents, Hormonal; Breast Neoplasms; Carcinoma, Ductal, Breast; Combined Modality Therapy; Double-Blind Method; Estrogens; Female; Humans; Letrozole; Mastectomy, Radical; Middle Aged; Neoadjuvant Therapy; Neoplasms, Hormone-Dependent; Nitriles; Palliative Care; Postmenopause; Progesterone; Prospective Studies; Remission Induction; Selective Estrogen Receptor Modulators; Tamoxifen; Treatment Outcome; Triazoles; Ultrasonography | 2011 |
Plasma letrozole concentrations in postmenopausal women with breast cancer are associated with CYP2A6 genetic variants, body mass index, and age.
Topics: Administration, Oral; Adult; Age Factors; Aged; Aged, 80 and over; Androstadienes; Antineoplastic Agents; Aryl Hydrocarbon Hydroxylases; Body Mass Index; Breast Neoplasms; Cross-Over Studies; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP3A; Female; Genetic Variation; Genotype; Humans; Letrozole; Middle Aged; Nitriles; Pharmacogenetics; Postmenopause; Prospective Studies; Triazoles | 2011 |
Comparison of efficacy of letrozole and clomiphene citrate in ovulation induction in Indian women with polycystic ovarian syndrome.
Topics: Adult; Chorionic Gonadotropin; Clomiphene; Endometrium; Estradiol; Female; Fertility Agents, Female; Humans; India; Infertility, Female; Letrozole; Nitriles; Ovarian Follicle; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Treatment Outcome; Triazoles; Young Adult | 2012 |
Final 5-year results of Z-FAST trial: adjuvant zoledronic acid maintains bone mass in postmenopausal breast cancer patients receiving letrozole.
Topics: Adult; Aged; Aged, 80 and over; Algorithms; Antineoplastic Agents; Bone and Bones; Bone Density; Bone Density Conservation Agents; Breast Neoplasms; Carcinoma; Chemotherapy, Adjuvant; Diphosphonates; Female; Follow-Up Studies; Humans; Imidazoles; Letrozole; Middle Aged; Nitriles; Organ Size; Osteoporosis, Postmenopausal; Postmenopause; Triazoles; Zoledronic Acid | 2012 |
Quality-adjusted survival analysis of first-line treatment of hormone-receptor-positive HER2+ metastatic breast cancer with letrozole alone or in combination with lapatinib.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Disease-Free Survival; Double-Blind Method; Female; Humans; Lapatinib; Letrozole; Nitriles; Quinazolines; Receptor, ErbB-2; Survival Rate; Triazoles | 2011 |
The efficacy and safety of neoadjuvant chemotherapy +/- letrozole in postmenopausal women with locally advanced breast cancer: a randomized phase III clinical trial.
Topics: Aged; Aged, 80 and over; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Humans; Letrozole; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Neutropenia; Nitriles; Postmenopause; Statistics, Nonparametric; Treatment Outcome; Triazoles; Tumor Burden | 2012 |
Immediate Administration of Zoledronic Acid Reduces Aromatase Inhibitor-Associated Bone Loss in Postmenopausal Women With Early Breast Cancer: 12-month analysis of the E-ZO-FAST trial.
Topics: Adult; Aged; Aged, 80 and over; Aromatase Inhibitors; Bone Density; Bone Density Conservation Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Diphosphonates; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Imidazoles; Letrozole; Middle Aged; Nitriles; Osteoporosis, Postmenopausal; Receptors, Estrogen; Treatment Outcome; Triazoles; Zoledronic Acid | 2012 |
Assessment of letrozole and tamoxifen alone and in sequence for postmenopausal women with steroid hormone receptor-positive breast cancer: the BIG 1-98 randomised clinical trial at 8·1 years median follow-up.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Australia; Biomarkers, Tumor; Breast Neoplasms; Cross-Over Studies; Disease-Free Survival; Double-Blind Method; Europe; Female; Humans; Kaplan-Meier Estimate; Letrozole; Neoplasm Recurrence, Local; Neoplasms, Second Primary; New Zealand; Nitriles; North America; Postmenopause; Proportional Hazards Models; Receptors, Steroid; Risk Factors; Selective Estrogen Receptor Modulators; South Africa; South America; Tamoxifen; Time Factors; Treatment Outcome; Triazoles | 2011 |
Longer-term outcomes of letrozole versus placebo after 5 years of tamoxifen in the NCIC CTG MA.17 trial: analyses adjusting for treatment crossover.
Topics: Aromatase Inhibitors; Breast Neoplasms; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Female; Humans; Letrozole; Middle Aged; Nitriles; Placebos; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles | 2012 |
Uptake of a randomized breast cancer prevention trial comparing letrozole to placebo in BRCA1/2 mutations carriers: the LIBER trial.
Topics: Adult; Aged; Antineoplastic Agents; BRCA1 Protein; BRCA2 Protein; Breast Neoplasms; Double-Blind Method; Feasibility Studies; Female; Follow-Up Studies; Genetic Predisposition to Disease; Heterozygote; Humans; Letrozole; Middle Aged; Mutation; Nitriles; Ovariectomy; Postmenopause; Prognosis; Prospective Studies; Retrospective Studies; Triazoles | 2012 |
A prospective double-blinded, randomized, placebo-controlled trial on the use of letrozole pretreatment with misoprostol for second-trimester medical abortion.
Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Adult; Aromatase Inhibitors; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Hospitals, University; Humans; Letrozole; Misoprostol; Nitriles; Pilot Projects; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Second; Time Factors; Triazoles; Young Adult | 2011 |
The protective effect of zoledronic acid on bone loss in postmenopausal women with early breast cancer treated with sequential tamoxifen and letrozole: a prospective, randomized, phase II trial.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Bone Density; Bone Density Conservation Agents; Breast Neoplasms; Diphosphonates; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Imidazoles; Letrozole; Middle Aged; Neoplasm Staging; Nitriles; Osteoporosis, Postmenopausal; Prospective Studies; Tamoxifen; Triazoles; Zoledronic Acid | 2011 |
High non-compliance in the use of letrozole after 2.5 years of extended adjuvant endocrine therapy. Results from the IDEAL randomized trial.
Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chemotherapy, Adjuvant; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Letrozole; Long-Term Care; Mastectomy, Segmental; Maximum Tolerated Dose; Middle Aged; Neoplasm Staging; Nitriles; Patient Compliance; Prospective Studies; Risk Assessment; Statistics, Nonparametric; Survival Rate; Time Factors; Treatment Outcome; Triazoles | 2012 |
Comparison of changes in the lipid profile of postmenopausal women with early stage breast cancer treated with exemestane or letrozole.
Topics: Adult; Aged; Aged, 80 and over; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Lipids; Middle Aged; Nitriles; Postmenopause; Tamoxifen; Triazoles | 2012 |
Randomized comparison of superovulation with letrozole vs. clomiphene citrate in an IUI program for women with recently surgically treated minimal to mild endometriosis.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Administration Schedule; Endometriosis; Female; Fertility Agents, Female; Humans; Infertility, Female; Insemination, Artificial; Letrozole; Nitriles; Pregnancy; Pregnancy Outcome; Prospective Studies; Superovulation; Treatment Outcome; Triazoles | 2012 |
Aromatase inhibitors or gonadotropin-releasing hormone agonists for the management of uterine adenomyosis: a randomized controlled trial.
Topics: Administration, Oral; Adolescent; Adult; Aromatase Inhibitors; Drug Administration Schedule; Endometriosis; Female; Fertility Preservation; Gonadotropin-Releasing Hormone; Goserelin; Humans; Injections, Subcutaneous; Letrozole; Nitriles; Premenopause; Single-Blind Method; Treatment Outcome; Triazoles; Uterine Diseases; Young Adult | 2012 |
The Pregnancy in Polycystic Ovary Syndrome II (PPCOS II) trial: rationale and design of a double-blind randomized trial of clomiphene citrate and letrozole for the treatment of infertility in women with polycystic ovary syndrome.
Topics: Adolescent; Adult; Antineoplastic Agents; Chi-Square Distribution; Clomiphene; Double-Blind Method; Female; Fertility Agents, Female; Health Status Indicators; Hirsutism; Humans; Hyperandrogenism; Infertility, Female; Letrozole; Middle Aged; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Quality of Life; Research Design; Triazoles; Women's Health; Young Adult | 2012 |
Comparison of treatment outcomes of infertile women by clomiphene citrate and letrozole with gonadotropins underwent intrauterine insemination.
Topics: Adult; Clomiphene; Female; Fertility; Fertility Agents, Female; Gonadotropins; Humans; Infertility, Female; Insemination, Artificial; Iran; Letrozole; Male; Nitriles; Ovulation; Ovulation Induction; Pregnancy; Pregnancy Rate; Treatment Outcome; Triazoles; Young Adult | 2012 |
Phase II trial with letrozole to maximum response as primary systemic therapy in postmenopausal patients with ER/PgR[+] operable breast cancer.
Topics: Aged; Aged, 80 and over; Aromatase Inhibitors; Breast Neoplasms; Female; Follow-Up Studies; Humans; Letrozole; Neoadjuvant Therapy; Neoplasm Staging; Nitriles; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Survival Rate; Time Factors; Treatment Outcome; Triazoles | 2012 |
Effect of letrozole on uterine artery Doppler flow indices prior to first-trimester termination of pregnancy: a randomized controlled trial.
Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Adult; Chorionic Gonadotropin; Estradiol; Female; Hong Kong; Humans; Letrozole; Middle Aged; Nitriles; Pregnancy; Pregnancy Trimester, First; Preoperative Care; Progesterone; Pulsatile Flow; Treatment Outcome; Triazoles; Ultrasonography, Doppler; Uterine Artery; Uterine Hemorrhage | 2012 |
Efficacy of zoledronic acid in postmenopausal Japanese women with early breast cancer receiving adjuvant letrozole: 12-month results.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Asian People; Bone Density; Bone Density Conservation Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Diphosphonates; Female; Humans; Imidazoles; Japan; Letrozole; Middle Aged; Neoplasm Staging; Nitriles; Postmenopause; Treatment Outcome; Triazoles; Zoledronic Acid | 2012 |
Predictors of aromatase inhibitor discontinuation as a result of treatment-emergent symptoms in early-stage breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Comorbidity; Female; Follow-Up Studies; Humans; Letrozole; Medication Adherence; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Prognosis; Prospective Studies; Triazoles; Withholding Treatment | 2012 |
CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the breast international group 1-98 trial.
Topics: Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Cytochrome P-450 CYP2D6; Disease-Free Survival; Drug Administration Schedule; Female; Genotype; Humans; International Cooperation; Kaplan-Meier Estimate; Letrozole; Middle Aged; Nitriles; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles | 2012 |
Circulating antimüllerian hormone levels in boys decline during early puberty and correlate with inhibin B.
Topics: Adolescent; Anti-Mullerian Hormone; Aromatase Inhibitors; Biomarkers; Child; Cross-Sectional Studies; Double-Blind Method; Down-Regulation; Growth Disorders; Hospitals, University; Humans; Hypogonadism; Inhibins; Kallmann Syndrome; Letrozole; Male; Nitriles; Placebos; Puberty; Time Factors; Treatment Outcome; Triazoles; Up-Regulation | 2012 |
Bone effect of adjuvant tamoxifen, letrozole or letrozole plus zoledronic acid in early-stage breast cancer: the randomized phase 3 HOBOE study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bone Density; Bone Density Conservation Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Diphosphonates; Estradiol; Female; Humans; Imidazoles; Letrozole; Middle Aged; Neoplasm Staging; Nitriles; Tamoxifen; Triazoles; Zoledronic Acid | 2012 |
Effect of letrozole on uterine tonus and contractility: a randomized controlled trial.
Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Administration, Intravaginal; Administration, Oral; Adult; Aromatase Inhibitors; Drug Synergism; Female; Humans; Letrozole; Misoprostol; Myometrium; Nitriles; Oxytocics; Pregnancy; Pregnancy Trimester, First; Preoperative Care; Time Factors; Triazoles; Uterine Contraction; Young Adult | 2012 |
A prospective, multicenter, controlled, observational study to evaluate the efficacy of a patient support program in improving patients' persistence to adjuvant aromatase inhibitor medication for postmenopausal, early stage breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Patient Compliance; Physician-Patient Relations; Postmenopause; Practice Patterns, Physicians'; Prospective Studies; Surveys and Questionnaires; Triazoles | 2012 |
Subjective cognitive complaints one year after ceasing adjuvant endocrine treatment for early-stage breast cancer.
Topics: Aromatase Inhibitors; Breast Neoplasms; Cognition; Estrogen Antagonists; Female; Humans; Letrozole; Neoplasm Staging; Nitriles; Quality of Life; Tamoxifen; Triazoles | 2012 |
Effects of a non-steroidal aromatase inhibitor on ovarian function in cattle.
Topics: Animals; Aromatase; Aromatase Inhibitors; Cattle; Cells, Cultured; Crosses, Genetic; Dose-Response Relationship, Drug; Estradiol; Estrous Cycle; Estrus Synchronization; Female; Follicle Stimulating Hormone; Granulosa Cells; Half-Life; Injections, Intravenous; Letrozole; Luteinizing Hormone; Nitriles; Oogenesis; Ovarian Follicle; Ovulation; Triazoles; Ultrasonography | 2012 |
Changes in hormonal profile and seminal parameters with use of aromatase inhibitors in management of infertile men with low testosterone to estradiol ratios.
Topics: Adult; Anastrozole; Aromatase Inhibitors; Estradiol; Hormones; Humans; Infertility, Male; Letrozole; Male; Nitriles; Organ Size; Semen Analysis; Testis; Testosterone; Triazoles | 2012 |
Comparison of the effects of letrozole and clomiphene citrate for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Adult; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Triazoles | 2012 |
Short-term and low-dose prednisolone administration reduces aromatase inhibitor-induced arthralgia in patients with breast cancer.
Topics: Aged; Aged, 80 and over; Anastrozole; Anti-Inflammatory Agents; Aromatase Inhibitors; Arthralgia; Breast Neoplasms; Female; Humans; Letrozole; Middle Aged; Nitriles; Prednisolone; Triazoles | 2012 |
A pilot study on the use of a 7-day course of letrozole followed by misoprostol for the termination of early pregnancy up to 63 days.
Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Adult; Aromatase Inhibitors; Chorionic Gonadotropin, beta Subunit, Human; Drug Administration Schedule; Estradiol; Estrogen Antagonists; Estrogen Receptor Modulators; Female; Hong Kong; Humans; Letrozole; Misoprostol; Nitriles; Patient Satisfaction; Pilot Projects; Pregnancy; Pregnancy Trimester, First; Pregnancy, Unwanted; Triazoles; Young Adult | 2012 |
Reduced methadone clearance during aromatase inhibition.
Topics: Aged; Analgesics, Opioid; Area Under Curve; Aromatase Inhibitors; Drug Interactions; Female; Half-Life; Humans; Letrozole; Metabolic Clearance Rate; Methadone; Middle Aged; Nitriles; Triazoles | 2012 |
Letrozole versus clomiphene citrate for superovulation in Egyptian women with unexplained infertility: a randomized controlled trial.
Topics: Adult; Chi-Square Distribution; Chorionic Gonadotropin; Clomiphene; Egypt; Endometrium; Endosonography; Estradiol; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitriles; Ovarian Follicle; Ovulation Induction; Pregnancy; Pregnancy Rate; Regional Blood Flow; Reproductive Control Agents; Statistics, Nonparametric; Triazoles; Young Adult | 2012 |
A randomized controlled trial comparing primary tumour resection plus systemic therapy with systemic therapy alone in metastatic breast cancer (PRIM-BC): Japan Clinical Oncology Group Study JCOG1017.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Letrozole; Mastectomy; Middle Aged; Neoplasm Staging; Nitriles; Paclitaxel; Prognosis; Prospective Studies; Survival Rate; Tamoxifen; Trastuzumab; Triazoles; Young Adult | 2012 |
Activated HER-receptors in predicting outcome of ER-positive breast cancer patients treated with adjuvant endocrine therapy.
Topics: Aged; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; ErbB Receptors; Female; Follow-Up Studies; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Letrozole; Mastectomy; Middle Aged; Nitriles; Phosphorylation; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; Tamoxifen; Treatment Outcome; Triazoles | 2012 |
A new look at tamoxifen: co-administration with letrozole in intrauterine insemination cycles.
Topics: Adult; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; Infertility; Insemination, Artificial; Letrozole; Menotropins; Nitriles; Ovulation Induction; Pregnancy; Prospective Studies; Tamoxifen; Treatment Outcome; Triazoles | 2013 |
Impact of premenopausal status at breast cancer diagnosis in women entered on the placebo-controlled NCIC CTG MA17 trial of extended adjuvant letrozole.
Topics: Aged; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Female; Humans; Letrozole; Middle Aged; Nitriles; Placebos; Postmenopause; Premenopause; Quality of Life; Survival; Tamoxifen; Treatment Outcome; Triazoles | 2013 |
Obesity and risk of recurrence or death after adjuvant endocrine therapy with letrozole or tamoxifen in the breast international group 1-98 trial.
Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Body Mass Index; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Estrogen Receptor Modulators; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Obesity; Odds Ratio; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Risk Assessment; Risk Factors; Tamoxifen; Treatment Outcome; Triazoles | 2012 |
Zoledronic acid (zoledronate) for postmenopausal women with early breast cancer receiving adjuvant letrozole (ZO-FAST study): final 60-month results.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Aromatase Inhibitors; Bone Density; Bone Density Conservation Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Diphosphonates; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Imidazoles; Letrozole; Lumbar Vertebrae; Middle Aged; Nitriles; Postmenopause; Triazoles; Zoledronic Acid | 2013 |
Is letrozole superior to clomiphene for ovarian stimulation prior to intrauterine insemination?
Topics: Adult; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Insemination, Artificial; Letrozole; Nitriles; Ovulation Induction; Pilot Projects; Pregnancy; Prospective Studies; Treatment Outcome; Triazoles | 2013 |
Changes in the size of rectovaginal endometriotic nodules infiltrating the rectum during hormonal therapies.
Topics: Adult; Aromatase Inhibitors; Calcium; Cholecalciferol; Contraceptives, Oral, Sequential; Contraceptives, Oral, Synthetic; Desogestrel; Endometriosis; Estrogen Receptor Modulators; Female; Humans; Image Processing, Computer-Assisted; Letrozole; Nitriles; Norethindrone; Norethindrone Acetate; Norpregnenes; Prospective Studies; Rectal Diseases; Treatment Outcome; Triazoles; Triptorelin Pamoate; Ultrasonography; Vaginal Diseases; Vitamins | 2013 |
Lipid concentrations in postmenopausal women on letrozole after 5 years of tamoxifen: an NCIC CTG MA.17 sub-study.
Topics: Aged; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Cholesterol; Cholesterol, HDL; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Letrozole; Lipids; Lipoprotein(a); Middle Aged; Nitriles; Postmenopause; Tamoxifen; Time Factors; Triazoles | 2012 |
Minimal stimulation protocol using letrozole versus microdose flare up GnRH agonist protocol in women with poor ovarian response undergoing ICSI.
Topics: Adult; Aromatase Inhibitors; Drug Resistance; Egypt; Estradiol; Female; Fertility Agents, Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone; Hormone Antagonists; Humans; Infertility, Female; Letrozole; Leuprolide; Menotropins; Nitriles; Ovary; Ovulation Induction; Pregnancy; Pregnancy Rate; Sperm Injections, Intracytoplasmic; Triazoles | 2013 |
Randomized phase III placebo-controlled trial of letrozole plus oral temsirolimus as first-line endocrine therapy in postmenopausal women with locally advanced or metastatic breast cancer.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Disease-Free Survival; Double-Blind Method; Female; Humans; Letrozole; Middle Aged; Neoplasm Metastasis; Nitriles; Placebos; Postmenopause; Sirolimus; Treatment Outcome; Triazoles | 2013 |
PIK3CA genotype and a PIK3CA mutation-related gene signature and response to everolimus and letrozole in estrogen receptor positive breast cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Proliferation; Class I Phosphatidylinositol 3-Kinases; Everolimus; Female; Gene Expression Regulation, Neoplastic; Genotype; Humans; Letrozole; Middle Aged; Mutation; Nitriles; Phosphatidylinositol 3-Kinases; Receptors, Estrogen; Sirolimus; TOR Serine-Threonine Kinases; Triazoles | 2013 |
Efficacy of combined metformin-letrozole in comparison with bilateral ovarian drilling in clomiphene-resistant infertile women with polycystic ovarian syndrome.
Topics: Adult; Aromatase Inhibitors; Blood Glucose; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Follicle Stimulating Hormone; Humans; Infertility, Female; Insulin; Letrozole; Luteinizing Hormone; Metformin; Nitriles; Ovary; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Testosterone; Triazoles; Young Adult | 2013 |
Letrozole usage adjuvant to gonadotropins for ovulation induction for patients with clomiphene citrate failure.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Therapy, Combination; Endometrium; Estradiol; Female; Fertility Agents, Female; Follicle Stimulating Hormone; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Treatment Failure; Triazoles; Ultrasonography; Young Adult | 2013 |
Effects of aromatase inhibition and androgen activity on serotonin and behavior in male macaques.
Topics: 5-alpha Reductase Inhibitors; Aggression; Analysis of Variance; Androgens; Animals; Aromatase; Aromatase Inhibitors; Azasteroids; Drug Interactions; Dutasteride; Fenfluramine; Letrozole; Macaca fascicularis; Male; Nitriles; Orchiectomy; Prolactin; Regression Analysis; Serotonin; Serotonin Agents; Sexual Behavior, Animal; Testosterone; Triazoles; Tryptophan Hydroxylase | 2013 |
Genetic associations with toxicity-related discontinuation of aromatase inhibitor therapy for breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Estrogen Receptor alpha; Female; Humans; Introns; Letrozole; Middle Aged; Models, Genetic; Multivariate Analysis; Nitriles; Polymorphism, Single Nucleotide; Prospective Studies; Treatment Failure; Triazoles | 2013 |
Multicenter phase II study of neoadjuvant lapatinib and trastuzumab with hormonal therapy and without chemotherapy in patients with human epidermal growth factor receptor 2-overexpressing breast cancer: TBCRC 006.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Administration Schedule; Female; Humans; Lapatinib; Letrozole; Lymphatic Metastasis; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Nitriles; Quinazolines; Receptor, ErbB-2; Receptors, Estrogen; Trastuzumab; Treatment Outcome; Triazoles; Up-Regulation | 2013 |
Increased pathological complete response rate after a long-term neoadjuvant letrozole treatment in postmenopausal oestrogen and/or progesterone receptor-positive breast cancer.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Cohort Studies; Drug Administration Schedule; Female; Humans; Ki-67 Antigen; Letrozole; Neoadjuvant Therapy; Nitriles; Receptors, Estrogen; Receptors, Progesterone; Triazoles | 2013 |
Phase II study assessing lapatinib added to letrozole in patients with progressive disease under aromatase inhibitor in metastatic breast cancer-Study BES 06.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Cohort Studies; Drug Resistance, Neoplasm; ErbB Receptors; Female; Humans; Lapatinib; Letrozole; Middle Aged; Neoplasm Grading; Nitriles; Quinazolines; Receptor, ErbB-2; Treatment Outcome; Triazoles | 2013 |
Efficacy of combined therapy of goserelin and letrozole on very young women with advanced breast cancer as first-line endocrine therapy.
Topics: Adolescent; Adult; Age of Onset; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Disease Progression; Drug Therapy, Combination; Female; Goserelin; Humans; Letrozole; Neoadjuvant Therapy; Nitriles; Pregnancy; Survival Analysis; Treatment Outcome; Triazoles; Young Adult | 2013 |
Evaluation of low-dose letrozole addition to ovulation induction in IVF.
Topics: Adult; Aromatase Inhibitors; Female; Fertilization in Vitro; Gonadotropins; Humans; Letrozole; Male; Nitriles; Ovulation Induction; Pregnancy; Triazoles | 2013 |
Prevalence of menopausal symptoms and their influence on adherence in women with breast cancer.
Topics: Aged; Anastrozole; Antineoplastic Agents, Hormonal; Anxiety; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Hot Flashes; Humans; Letrozole; Medication Adherence; Middle Aged; Musculoskeletal Pain; Nitriles; Sleep Wake Disorders; Time Factors; Triazoles; Urinary Bladder Diseases; Vaginal Diseases | 2014 |
Somatic and psychological effects of low-dose aromatase inhibition in men with obesity-related hypogonadotropic hypotestosteronemia.
Topics: Adult; Androgens; Aromatase Inhibitors; Blood Glucose; Body Composition; Body Mass Index; Bone Density; Double-Blind Method; Energy Intake; Estradiol; Exercise Tolerance; Hormones; Humans; Hypogonadism; Letrozole; Lipid Metabolism; Luteinizing Hormone; Male; Middle Aged; Neuropsychological Tests; Nitriles; Obesity, Morbid; Psychometrics; Testosterone; Triazoles | 2013 |
The effect of letrozole with misoprostol for medical termination of pregnancy on the expression of steroid receptors in the placenta.
Topics: Abortifacient Agents; Abortion, Induced; Apoptosis; Estrogen Receptor alpha; Female; Gene Expression; Humans; Letrozole; Nitriles; Placenta; Pregnancy; Pregnancy Trimester, Second; Proliferating Cell Nuclear Antigen; Receptors, Progesterone; RNA, Messenger; Triazoles | 2013 |
Aromatase inhibitor-induced modulation of breast density: clinical and genetic effects.
Topics: Adult; Aged; Aged, 80 and over; Androstadienes; Aromatase; Aromatase Inhibitors; Breast; Breast Neoplasms; Chemotherapy, Adjuvant; Estrogens; Female; Humans; Letrozole; Mammography; Middle Aged; Nitriles; Polymorphism, Single Nucleotide; Postmenopause; Prospective Studies; Triazoles | 2013 |
Letrozole ovulation induction: an effective option in endometrial preparation for frozen-thawed embryo transfer.
Topics: Abortion, Spontaneous; Adult; Aromatase Inhibitors; Birth Rate; Case-Control Studies; China; Cryopreservation; Embryo Implantation; Embryo Transfer; Female; Hormone Replacement Therapy; Humans; Letrozole; Nitriles; Ovarian Follicle; Ovulation Induction; Pregnancy; Pregnancy Outcome; Pregnancy Rate; Pregnancy, Ectopic; Triazoles | 2014 |
Multivariate analysis to predict letrozole efficacy in improving sperm count of non-obstructive azoospermic and cryptozoospermic patients: a pilot study.
Topics: Adult; Azoospermia; Double-Blind Method; Humans; Letrozole; Male; Middle Aged; Multivariate Analysis; Nitriles; Pilot Projects; Sperm Count; Triazoles | 2013 |
Phase 2 trial of aromatase inhibition with letrozole in patients with uterine leiomyosarcomas expressing estrogen and/or progesterone receptors.
Topics: Adult; Aged; Antineoplastic Agents; Aromatase Inhibitors; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Kaplan-Meier Estimate; Leiomyosarcoma; Letrozole; Middle Aged; Nitriles; Proportional Hazards Models; Prospective Studies; Receptors, Estrogen; Receptors, Progesterone; Treatment Outcome; Triazoles; Uterine Neoplasms | 2014 |
Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitriles; Ovarian Follicle; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Treatment Outcome; Triazoles; Young Adult | 2013 |
Bone mineral density and circulating biomarkers in the BIG 1-98 trial comparing adjuvant letrozole, tamoxifen and their sequences.
Topics: Aged; Alkaline Phosphatase; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Bone Density; Breast Neoplasms; Chemotherapy, Adjuvant; Collagen Type I; Double-Blind Method; Drug Administration Schedule; Female; Humans; Letrozole; Middle Aged; Nitriles; Osteocalcin; Osteoporosis, Postmenopausal; Peptides; Postmenopause; Prospective Studies; Tamoxifen; Triazoles | 2014 |
FemZone trial: a randomized phase II trial comparing neoadjuvant letrozole and zoledronic acid with letrozole in primary breast cancer patients.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Diphosphonates; Female; Humans; Imidazoles; Letrozole; Middle Aged; Neoadjuvant Therapy; Nitriles; Prospective Studies; Triazoles; Zoledronic Acid | 2014 |
Optimum duration of neoadjuvant letrozole to permit breast conserving surgery.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Mastectomy, Segmental; Middle Aged; Neoadjuvant Therapy; Neoplasm Grading; Neoplasm Metastasis; Neoplasm Staging; Nitriles; Time Factors; Treatment Outcome; Triazoles | 2014 |
Double-blind, placebo-controlled, multicenter, randomized, phase IIb neoadjuvant study of letrozole-lapatinib in postmenopausal hormone receptor-positive, human epidermal growth factor receptor 2-negative, operable breast cancer.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Double-Blind Method; Female; Humans; Ki-67 Antigen; Lapatinib; Letrozole; Middle Aged; Mutation; Neoadjuvant Therapy; Nitriles; Phosphatidylinositol 3-Kinases; Phosphorylation; Postmenopause; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Triazoles | 2014 |
Comparing letrozole with medroxyprogesterone acetate (MPA) as hormonal therapy for simple endometrial hyperplasia without atypia in adult and middle-aged women.
Topics: Adult; Antineoplastic Agents, Hormonal; Biopsy; Curettage; Dizziness; Endometrial Hyperplasia; Estradiol; Female; Fertility Preservation; Headache; Humans; Letrozole; Medroxyprogesterone Acetate; Middle Aged; Nitriles; Triazoles; Young Adult | 2013 |
Phase II randomized trial of neoadjuvant metformin plus letrozole versus placebo plus letrozole for estrogen receptor positive postmenopausal breast cancer (METEOR).
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Clinical Protocols; Female; Humans; Letrozole; Metformin; Neoadjuvant Therapy; Nitriles; Postmenopause; Receptors, Estrogen; Research Design; Triazoles | 2014 |
Stand up to cancer phase Ib study of pan-phosphoinositide-3-kinase inhibitor buparlisib with letrozole in estrogen receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer.
Topics: Adult; Aged; Aminopyridines; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluorodeoxyglucose F18; Humans; Letrozole; Middle Aged; Morpholines; Multimodal Imaging; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Positron-Emission Tomography; Protein Kinase Inhibitors; Radiopharmaceuticals; Receptor, ErbB-2; Receptors, Estrogen; Tomography, X-Ray Computed; Triazoles | 2014 |
Bosutinib in combination with the aromatase inhibitor letrozole: a phase II trial in postmenopausal women evaluating first-line endocrine therapy in locally advanced or metastatic hormone receptor-positive/HER2-negative breast cancer.
Topics: Aniline Compounds; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Disease-Free Survival; Female; Humans; Letrozole; Nitriles; Postmenopause; Protein Kinase Inhibitors; Quinolines; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Triazoles | 2014 |
The impact of educational materials on compliance and persistence rates with adjuvant aromatase inhibitor treatment: first-year results from the compliance of aromatase inhibitors assessment in daily practice through educational approach (CARIATIDE) study
Topics: Aged; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Lymph Node Excision; Mastectomy; Medication Adherence; Middle Aged; Nitriles; Patient Education as Topic; Postmenopause; Triazoles | 2014 |
Health-related quality of life and psychological distress during neoadjuvant endocrine therapy with letrozole to determine endocrine responsiveness in postmenopausal breast cancer.
Topics: Aged; Antineoplastic Agents, Hormonal; Breast Neoplasms; Disease-Free Survival; Female; Humans; Letrozole; Middle Aged; Neoadjuvant Therapy; Nitriles; Postmenopause; Quality of Life; Stress, Psychological; Surveys and Questionnaires; Triazoles | 2014 |
[Clinical efficacy of letrozole in boys with idiopathic central precocious puberty].
Topics: Adolescent; Aromatase Inhibitors; Body Height; Bone Development; Gonadal Steroid Hormones; Humans; Letrozole; Male; Nitriles; Puberty, Precocious; Testis; Triazoles | 2014 |
Patient-reported symptoms and discontinuation of adjuvant aromatase inhibitor therapy.
Topics: Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Middle Aged; Nitriles; Prospective Studies; Surveys and Questionnaires; Survival Analysis; Treatment Outcome; Triazoles | 2014 |
Triggering final oocyte maturation with gonadotropin-releasing hormone agonist (GnRHa) versus human chorionic gonadotropin (hCG) in breast cancer patients undergoing fertility preservation: an extended experience.
Topics: Adult; Anti-Mullerian Hormone; Breast Neoplasms; Chorionic Gonadotropin; Female; Fertility Preservation; Gonadotropin-Releasing Hormone; Humans; In Vitro Oocyte Maturation Techniques; Letrozole; Nitriles; Ovarian Hyperstimulation Syndrome; Ovulation Induction; Triazoles | 2014 |
Evaluation of gingival inflammation in patients using ovulation induction drugs before and after scaling.
Topics: Adult; Aromatase Inhibitors; Case-Control Studies; Clomiphene; Dental Plaque Index; Dental Scaling; Educational Status; Estrogen Antagonists; Female; Fertility Agents, Female; Follow-Up Studies; Gingival Hemorrhage; Gingivitis; Humans; Income; Letrozole; Nitriles; Oral Hygiene; Ovulation Induction; Periodontal Index; Social Class; Toothbrushing; Triazoles | 2013 |
Randomized trial of a telephone-based weight loss intervention in postmenopausal women with breast cancer receiving letrozole: the LISA trial.
Topics: Antineoplastic Agents; Breast Neoplasms; Exercise; Female; Follow-Up Studies; Humans; Letrozole; Life Style; Middle Aged; Neoplasm Staging; Nitriles; Obesity; Postmenopause; Prognosis; Quality of Life; Surveys and Questionnaires; Telephone; Triazoles; Weight Loss | 2014 |
An effective alternative to only gonadotrophin for controlled ovarian stimulation in unexplained infertility patients undergoing intra-uterine insemination: a clinical trial.
Topics: Adult; Aromatase Inhibitors; Drug Therapy, Combination; Female; Follicle Stimulating Hormone; Humans; Infertility, Female; Insemination, Artificial; Letrozole; Male; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Triazoles | 2013 |
Extended therapy with letrozole and ovarian suppression in premenopausal patients with breast cancer after tamoxifen.
Topics: Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Feasibility Studies; Female; Follow-Up Studies; Gonadotropin-Releasing Hormone; Humans; Letrozole; Middle Aged; Neoplasm Grading; Neoplasm Staging; Nitriles; Ovariectomy; Premenopause; Prognosis; Survival Rate; Tamoxifen; Triazoles | 2014 |
Letrozole versus clomiphene for infertility in the polycystic ovary syndrome.
Topics: Adult; Clomiphene; Double-Blind Method; Female; Fertility Agents, Female; Humans; Infertility, Female; Kaplan-Meier Estimate; Letrozole; Live Birth; Luteal Phase; Male; Nitriles; Ovulation; Polycystic Ovary Syndrome; Pregnancy; Quality of Life; Triazoles | 2014 |
Electroacupuncture for fatigue, sleep, and psychological distress in breast cancer patients with aromatase inhibitor-related arthralgia: a randomized trial.
Topics: Aged; Anastrozole; Androstadienes; Anxiety; Aromatase Inhibitors; Arthralgia; Breast Neoplasms; Depression; Electroacupuncture; Fatigue; Female; Humans; Letrozole; Middle Aged; Nitriles; Quality of Life; Sleep Wake Disorders; Stress, Psychological; Treatment Outcome; Triazoles | 2014 |
Letrozole vs anastrozole for height augmentation in short pubertal males: first year data.
Topics: Adolescent; Anastrozole; Aromatase Inhibitors; Body Height; Child; Estradiol; Growth Disorders; Humans; Letrozole; Luteinizing Hormone; Male; Nitriles; Puberty; Testosterone; Treatment Outcome; Triazoles | 2014 |
Preoperative treatment with letrozole in patients undergoing laparoscopic myomectomy of large uterine myomas: a prospective non-randomized study.
Topics: Adult; Antineoplastic Agents; Blood Loss, Surgical; Chemotherapy, Adjuvant; Cicatrix; Contraceptives, Oral, Synthetic; Drug Therapy, Combination; Female; Humans; Laparoscopy; Leiomyoma; Letrozole; Neoadjuvant Therapy; Nitriles; Norethindrone; Norethindrone Acetate; Operative Time; Premenopause; Prospective Studies; Single-Blind Method; Triazoles; Tumor Burden; Ultrasonography; Uterine Neoplasms | 2014 |
Effects of different doses of letrozole on the incidence of early-onset ovarian hyperstimulation syndrome after oocyte retrieval.
Topics: Adult; Aromatase Inhibitors; Biomarkers; China; Dose-Response Relationship, Drug; Embryo Transfer; Estradiol; Female; Fertilization in Vitro; Humans; Incidence; Letrozole; Luteinizing Hormone; Nitriles; Oocyte Retrieval; Ovarian Hyperstimulation Syndrome; Ovulation Induction; Progesterone; Severity of Illness Index; Time Factors; Treatment Outcome; Triazoles; Vascular Endothelial Growth Factor A | 2014 |
Effects of combining low‑dose aspirin with a Chinese patent medicine on follicular blood flow and pregnancy outcome.
Topics: Adult; Aspirin; Drug Therapy, Combination; Drugs, Chinese Herbal; Endometrium; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitriles; Ovarian Follicle; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Triazoles; Ultrasonography; Young Adult | 2014 |
NEOCENT: a randomised feasibility and translational study comparing neoadjuvant endocrine therapy with chemotherapy in ER-rich postmenopausal primary breast cancer.
Topics: Adult; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Disease-Free Survival; Female; Humans; Letrozole; MicroRNAs; Middle Aged; Neoadjuvant Therapy; Nitriles; Postmenopause; Quality of Life; Receptors, Estrogen; Triazoles | 2014 |
Effects of zoledronic acid and the association between its efficacy and γδT cells in postmenopausal women with breast cancer treated with preoperative hormonal therapy: a study protocol.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Clinical Protocols; Diphosphonates; Female; Humans; Imidazoles; Letrozole; Nitriles; Postmenopause; Preoperative Care; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes; Triazoles; Zoledronic Acid | 2014 |
Phase II study evaluating efficacy and safety of everolimus with letrozole for management of advanced (unresectable or metastatic) non-small cell lung cancer after failure of platinum-based treatment: a preliminary analysis of toxicity.
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Carcinoma, Non-Small-Cell Lung; Everolimus; Female; Humans; Letrozole; Lung Diseases; Lung Neoplasms; Male; Middle Aged; Nitriles; Organoplatinum Compounds; Sirolimus; Smoking; Triazoles | 2015 |
The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study.
Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p16; Disease-Free Survival; Drug Administration Schedule; Europe; Female; Humans; Intention to Treat Analysis; Letrozole; Middle Aged; Molecular Targeted Therapy; Nitriles; North America; Piperazines; Postmenopause; Proportional Hazards Models; Protein Kinase Inhibitors; Pyridines; Receptor, ErbB-2; Receptors, Estrogen; Republic of Korea; South Africa; Time Factors; Treatment Outcome; Triazoles | 2015 |
Does patient education work in breast cancer? Final results from the global CARIATIDE study.
Topics: Aged; Anastrozole; Androstadienes; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Middle Aged; Nitriles; Patient Compliance; Patient Education as Topic; Tamoxifen; Triazoles | 2015 |
Electroretinographic and optical coherence tomography findings in breast cancer patients using aromatase inhibitors.
Topics: Anastrozole; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Electroretinography; Evoked Potentials, Visual; Female; Humans; Letrozole; Middle Aged; Nerve Fibers; Nitriles; Optic Nerve; Retina; Tomography, Optical Coherence; Triazoles; Visual Acuity | 2016 |
[Relationship between letrozole administration during the luteal phase after oocyte retrieval and the early-stage ovarian hyperstimulation syndrome oocurrence].
Topics: Aromatase Inhibitors; Estradiol; Female; Fertilization in Vitro; Humans; Infertility, Female; Letrozole; Luteal Phase; Nitriles; Oocyte Retrieval; Ovarian Hyperstimulation Syndrome; Progesterone; Triazoles; Vascular Endothelial Growth Factor A | 2014 |
Phase II study of everolimus and letrozole in patients with recurrent endometrial carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Bayes Theorem; beta Catenin; Biomarkers, Tumor; Cohort Studies; Disease-Free Survival; DNA Mutational Analysis; Endometrial Neoplasms; Endometriosis; Everolimus; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Immunosuppressive Agents; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Receptors, Estrogen; Receptors, Progesterone; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Treatment Outcome; Triazoles | 2015 |
Phase III trial evaluating the addition of bevacizumab to endocrine therapy as first-line treatment for advanced breast cancer: the letrozole/fulvestrant and avastin (LEA) study.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Breast Neoplasms; Disease-Free Survival; Drug Resistance, Neoplasm; Estradiol; Female; Fulvestrant; Germany; Hormones; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Spain; Treatment Outcome; Triazoles; Vascular Endothelial Growth Factor A | 2015 |
Assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trial: baseline characteristics.
Topics: Adult; Clomiphene; Female; Fertility Agents, Female; Gonadotropins; Humans; Infertility, Female; Letrozole; Male; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Outcome; Pregnancy, Multiple; Quality of Life; Triazoles | 2015 |
Impact of Male and Female Weight, Smoking, and Intercourse Frequency on Live Birth in Women With Polycystic Ovary Syndrome.
Topics: Adolescent; Adult; Body Mass Index; Body Weight; Clomiphene; Coitus; Female; Fertility Agents, Female; Humans; Infant, Newborn; Infertility, Male; Letrozole; Live Birth; Male; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Complications; Smoking; Triazoles; Young Adult | 2015 |
5-year follow-up of a randomized controlled trial of immediate versus delayed zoledronic acid for the prevention of bone loss in postmenopausal women with breast cancer starting letrozole after tamoxifen: N03CC (Alliance) trial.
Topics: Aged; Antineoplastic Agents; Bone Density; Bone Density Conservation Agents; Breast Neoplasms; Breast Neoplasms, Male; Chemotherapy, Adjuvant; Diphosphonates; Disease Progression; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Imidazoles; Letrozole; Male; Middle Aged; Nitriles; Osteoporosis, Postmenopausal; Postmenopause; Tamoxifen; Triazoles; Zoledronic Acid | 2015 |
Effect of Primary Letrozole Treatment on Tumor Expression of mTOR and HIF-1α and Relation to Clinical Response.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Drug Administration Schedule; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Letrozole; Middle Aged; Nitriles; Phosphorylation; Receptors, Estrogen; Signal Transduction; TOR Serine-Threonine Kinases; Treatment Outcome; Triazoles | 2015 |
A phase III randomized multicenter trial evaluating cognition in post-menopausal breast cancer patients receiving adjuvant hormonotherapy.
Topics: Aged; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Cognition Disorders; Female; Humans; Letrozole; Memory; Middle Aged; Nitriles; Postmenopause; Psychomotor Performance; Quality of Life; Tamoxifen; Triazoles | 2015 |
Relative Effectiveness of Letrozole Compared With Tamoxifen for Patients With Lobular Carcinoma in the BIG 1-98 Trial.
Topics: Adult; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Ki-67 Antigen; Letrozole; Middle Aged; Nitriles; Receptor, ErbB-2; Tamoxifen; Treatment Outcome; Triazoles | 2015 |
Reduction in Endometrioma Size with Three Months of Aromatase Inhibition and Progestin Add-Back.
Topics: Adult; Aromatase Inhibitors; Cohort Studies; Drug Therapy, Combination; Endometriosis; Female; Humans; Letrozole; Longitudinal Studies; Nitriles; Norethindrone; Norethindrone Acetate; Pain Measurement; Pelvic Pain; Progestins; Treatment Outcome; Triazoles; Young Adult | 2015 |
Outcomes of special histotypes of breast cancer after adjuvant endocrine therapy with letrozole or tamoxifen in the monotherapy cohort of the BIG 1-98 trial.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Breast Neoplasms; Carcinoma, Ductal, Breast; Chemotherapy, Adjuvant; Cohort Studies; Disease-Free Survival; Female; Follow-Up Studies; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Tamoxifen; Treatment Outcome; Triazoles | 2015 |
Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility.
Topics: Adolescent; Adult; Clomiphene; Female; Fertility Agents, Female; Gonadotropins; Humans; Infertility, Female; Letrozole; Live Birth; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Pregnancy, Multiple; Triazoles; Young Adult | 2015 |
Identifying treatment effect heterogeneity in clinical trials using subpopulations of events: STEPP.
Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Data Interpretation, Statistical; Double-Blind Method; Female; Humans; Letrozole; Nitriles; Outcome Assessment, Health Care; Research Design; Tamoxifen; Treatment Outcome; Triazoles | 2016 |
Phase I/II dose-escalation study of PI3K inhibitors pilaralisib or voxtalisib in combination with letrozole in patients with hormone-receptor-positive and HER2-negative metastatic breast cancer refractory to a non-steroidal aromatase inhibitor.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Drug Resistance, Neoplasm; Female; Humans; Letrozole; Maximum Tolerated Dose; Middle Aged; Mutation; Neoplasm Grading; Neoplasm Staging; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Retreatment; Sulfonamides; Treatment Outcome; Triazoles | 2015 |
Comparison of letrazole and clomiphene citrate in women with polycystic ovaries undergoing ovarian stimulation.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Prospective Studies; Triazoles; Young Adult | 2015 |
Effects of Letrozole-HMG and Clomiphene-HMG on Incidence of Luteinized Unruptured Follicle Syndrome in Infertile Women Undergoing Induction Ovulation and Intrauterine Insemination: A Randomised Trial.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Female; Follicular Phase; Humans; Infertility, Female; Insemination, Artificial; Letrozole; Luteinizing Hormone; Nitriles; Ovarian Follicle; Ovulation Induction; Pregnancy; Prospective Studies; Syndrome; Triazoles | 2015 |
Comparison of GnRh Agonist Microdose Flare Up and GnRh Antagonist/Letrozole in Treatment of Poor Responder Patients in Intra Cytoplaspic Sperm Injection: Randomized Clinical Trial.
Topics: Adult; Aromatase Inhibitors; Female; Gonadotropin-Releasing Hormone; Humans; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Sperm Injections, Intracytoplasmic; Triazoles | 2015 |
ESR1 and ESR2 polymorphisms in the BIG 1-98 trial comparing adjuvant letrozole versus tamoxifen or their sequence for early breast cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Double-Blind Method; Early Detection of Cancer; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Hot Flashes; Humans; Letrozole; Middle Aged; Nitriles; Polymorphism, Single Nucleotide; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles | 2015 |
A randomized controlled trial of clomifene citrate, metformin, and pioglitazone versus letrozole, metformin, and pioglitazone for clomifene-citrate-resistant polycystic ovary syndrome.
Topics: Adult; Clomiphene; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Egypt; Female; Fertility Agents, Female; Humans; Infertility, Female; Intention to Treat Analysis; Letrozole; Metformin; Nitriles; Ovulation; Ovulation Induction; Pioglitazone; Polycystic Ovary Syndrome; Prospective Studies; Thiazolidinediones; Triazoles | 2016 |
Use of letrozole and clomiphene citrate combined with gonadotropins in clomiphene-resistant infertile women with polycystic ovary syndrome: a prospective study.
Topics: Adult; Clomiphene; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Menotropins; Nitriles; Ovarian Hyperstimulation Syndrome; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Prospective Studies; Treatment Outcome; Triazoles; Young Adult | 2015 |
Double-Blind, Randomized Trial of Alternative Letrozole Dosing Regimens in Postmenopausal Women with Increased Breast Cancer Risk.
Topics: Antineoplastic Agents; Breast Neoplasms; Carcinoma in Situ; Carcinoma, Lobular; Double-Blind Method; Female; Follow-Up Studies; Humans; Letrozole; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Nitriles; Postmenopause; Prognosis; Triazoles | 2016 |
Concurrent or sequential letrozole with adjuvant breast radiotherapy: final results of the CO-HO-RT phase II randomized trial.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Combined Modality Therapy; Female; Fibrosis; Genome-Wide Association Study; Humans; Letrozole; Middle Aged; Nitriles; Nuclear Proteins; Polymorphism, Single Nucleotide; Radiotherapy, Adjuvant; Triazoles | 2016 |
Comparison of the effects of letrozole and cabergoline on vascular permeability, ovarian diameter, ovarian tissue VEGF levels, and blood PEDF levels, in a rat model of ovarian hyperstimulation syndrome.
Topics: Animals; Cabergoline; Capillary Permeability; Chorionic Gonadotropin; Ergolines; Eye Proteins; Female; Gonadotropins, Equine; Humans; Letrozole; Nerve Growth Factors; Nitriles; Ovarian Hyperstimulation Syndrome; Ovary; Pregnancy; Prospective Studies; Rats; Rats, Wistar; Serpins; Triazoles; Vascular Endothelial Growth Factor A | 2016 |
The effect of 7 days of letrozole pretreatment combined with misoprostol on the expression of progesterone receptor and apoptotic factors of placental and decidual tissues from first-trimester abortion: a randomized controlled trial.
Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Adult; Apoptosis; Biomarkers; Decidua; Double-Blind Method; Female; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Letrozole; Misoprostol; Nitriles; Placebos; Placenta; Pregnancy; Pregnancy Trimester, First; Receptors, Progesterone; Triazoles | 2016 |
Phase I Study of Panobinostat (LBH589) and Letrozole in Postmenopausal Metastatic Breast Cancer Patients.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Hydroxamic Acids; Immunoenzyme Techniques; Indoles; Letrozole; Lymphatic Metastasis; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Nitriles; Panobinostat; Postmenopause; Prognosis; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Survival Rate; Triazoles | 2016 |
Observation versus late reintroduction of letrozole as adjuvant endocrine therapy for hormone receptor-positive breast cancer (ANZ0501 LATER): an open-label randomised, controlled trial.
Topics: Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Australia; Breast Neoplasms; Combined Modality Therapy; Disease-Free Survival; Female; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Treatment Outcome; Triazoles | 2016 |
Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS).
Topics: Adult; Aged; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Arthralgia; Bone Density; Breast Neoplasms; Cholecalciferol; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Letrozole; Middle Aged; Musculoskeletal Diseases; Nitriles; Triazoles; Vitamin D | 2016 |
Incidence and Predictive Factors for Recovery of Ovarian Function in Amenorrheic Women in Their 40s Treated With Letrozole.
Topics: Adult; Amenorrhea; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Estradiol; Female; Follicle Stimulating Hormone; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Prospective Studies; Receptors, Estrogen; Triazoles | 2016 |
Impact of palbociclib plus letrozole on pain severity and pain interference with daily activities in patients with estrogen receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer as first-line treatment.
Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Cancer Pain; Disease-Free Survival; Drug Therapy, Combination; Female; Humans; Letrozole; Middle Aged; Nitriles; Pain Measurement; Piperazines; Pyridines; Receptor, ErbB-2; Receptors, Estrogen; Triazoles | 2016 |
Circulating makorin ring finger protein 3 levels decline in boys before the clinical onset of puberty.
Topics: Adolescent; Aromatase Inhibitors; Child; Double-Blind Method; Growth Disorders; Humans; Letrozole; Male; Nitriles; Puberty; Ribonucleoproteins; Treatment Outcome; Triazoles; Ubiquitin-Protein Ligases | 2016 |
New onset vasomotor symptoms but not musculoskeletal symptoms associate with clinical outcomes on extended adjuvant letrozole - Analyses from NCIC CTG MA.17.
Topics: Aged; Antineoplastic Agents; Autonomic Nervous System Diseases; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Letrozole; Middle Aged; Multivariate Analysis; Musculoskeletal Diseases; Nitriles; Proportional Hazards Models; Tamoxifen; Time Factors; Treatment Outcome; Triazoles; Vasomotor System | 2016 |
The effect of clomiphene citrate vs. letrozole on post-coital tests.
Topics: Adult; Aromatase Inhibitors; Cervix Mucus; Clomiphene; Coitus; Female; Fertility Agents, Female; Humans; Letrozole; Nitriles; Ovarian Follicle; Ovulation Induction; Pilot Projects; Triazoles | 2016 |
Phase III Trial Evaluating Letrozole As First-Line Endocrine Therapy With or Without Bevacizumab for the Treatment of Postmenopausal Women With Hormone Receptor-Positive Advanced-Stage Breast Cancer: CALGB 40503 (Alliance).
Topics: Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Breast Neoplasms; Disease-Free Survival; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Treatment Outcome; Triazoles | 2016 |
Treatment Adherence and Its Impact on Disease-Free Survival in the Breast International Group 1-98 Trial of Tamoxifen and Letrozole, Alone and in Sequence.
Topics: Aged; Breast Neoplasms; Disease-Free Survival; Double-Blind Method; Female; Humans; Letrozole; Medication Adherence; Middle Aged; Nitriles; Tamoxifen; Triazoles | 2016 |
Effects of vitamin D and calcium supplementation on side effects profile in patients of breast cancer treated with letrozole.
Topics: Arthralgia; Breast Neoplasms; Calcium; Cholecalciferol; Dietary Supplements; Female; Humans; Letrozole; Middle Aged; Nitriles; Triazoles; Vitamin D | 2016 |
A randomized, single-blind, prospective trial comparing three different gonadotropin doses with or without addition of letrozole during ovulation stimulation in patients with poor ovarian response.
Topics: Adolescent; Adult; Dose-Response Relationship, Drug; Drug Therapy, Combination; Embryo Transfer; Female; Fertility Agents, Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Humans; Infertility, Female; Letrozole; Menotropins; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Prospective Studies; Single-Blind Method; Treatment Outcome; Triazoles; Young Adult | 2016 |
Extending Aromatase-Inhibitor Adjuvant Therapy to 10 Years.
Topics: Aged; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Incidence; Kaplan-Meier Estimate; Letrozole; Middle Aged; Nitriles; Postmenopause; Quality of Life; Recurrence; Secondary Prevention; Triazoles | 2016 |
Randomized controlled trial of letrozole, berberine, or a combination for infertility in the polycystic ovary syndrome.
Topics: Administration, Oral; Adult; Berberine; China; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Fertility; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Live Birth; Nitriles; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Time Factors; Treatment Outcome; Triazoles | 2016 |
Ribociclib plus letrozole in early breast cancer: A presurgical, window-of-opportunity study.
Topics: Aged; Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclin D2; Cyclin D3; Cyclin E; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; DNA, Neoplasm; Female; Gene Expression; Humans; Ki-67 Antigen; Letrozole; Middle Aged; Neoadjuvant Therapy; Nitriles; Oncogene Proteins; Purines; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Retinoblastoma Protein; Signal Transduction; Triazoles | 2016 |
Efficacy and safety of palbociclib in combination with letrozole as first-line treatment of ER-positive, HER2-negative, advanced breast cancer: expanded analyses of subgroups from the randomized pivotal trial PALOMA-1/TRIO-18.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Female; Humans; Letrozole; Middle Aged; Neoplasm Staging; Neutropenia; Nitriles; Piperazines; Pyridines; Receptor, ErbB-2; Receptors, Estrogen; Retreatment; Survival Analysis; Treatment Outcome; Triazoles | 2016 |
A highly sensitive LC-MS/MS method for determination of ketoconazole in human plasma: Application to a clinical study of the exposure to ketoconazole in patients after topical administration.
Topics: Administration, Topical; Adult; Chromatography, High Pressure Liquid; Dermatitis, Seborrheic; Drug Stability; Humans; Ketoconazole; Letrozole; Liquid-Liquid Extraction; Nitriles; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Triazoles; Young Adult | 2016 |
Short-Term Estrogen Withdrawal Increases Adiposity in Healthy Men.
Topics: Adiposity; Adult; Androgens; Aromatase Inhibitors; Blood Glucose; Double-Blind Method; Estradiol; Gonadotropin-Releasing Hormone; Hormone Antagonists; Humans; Insulin Resistance; Letrozole; Male; Middle Aged; Nitriles; Testosterone; Triazoles; Young Adult | 2016 |
Phase II trial of neoadjuvant letrozole and lapatinib in Asian postmenopausal women with estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2)-positive breast cancer [Neo-ALL-IN]: Highlighting the TILs, ER expressional change after ne
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asian People; Biomarkers, Tumor; Breast Neoplasms; Combined Modality Therapy; Female; Humans; Lapatinib; Letrozole; Lymphocyte Count; Lymphocytes, Tumor-Infiltrating; Mastectomy; Middle Aged; Neoadjuvant Therapy; Nitriles; Positron-Emission Tomography; Postmenopause; Quinazolines; Receptor, ErbB-2; Receptors, Estrogen; Triazoles | 2016 |
Effect of letrozole on moderate and severe early-onset ovarian hyperstimulation syndrome in high-risk women: a prospective randomized trial.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aromatase Inhibitors; Ascites; Aspirin; Chorionic Gonadotropin; Estradiol; Female; Humans; Letrozole; Luteal Phase; Nitriles; Oocyte Retrieval; Ovarian Hyperstimulation Syndrome; Ovulation Induction; Primary Prevention; Reproductive Control Agents; Risk Assessment; Severity of Illness Index; Triazoles; Vascular Endothelial Growth Factor A | 2017 |
Randomized Trial of Aromatase Inhibitors, Growth Hormone, or Combination in Pubertal Boys with Idiopathic, Short Stature.
Topics: Adolescent; Anastrozole; Aromatase Inhibitors; Body Composition; Body Height; Drug Therapy, Combination; Dwarfism; Growth Hormone; Humans; Letrozole; Male; Nitriles; Outcome Assessment, Health Care; Puberty; Triazoles | 2016 |
Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer.
Topics: Adult; Aged; Aged, 80 and over; Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Female; Humans; Kaplan-Meier Estimate; Letrozole; Middle Aged; Neoplasm Staging; Nitriles; Purines; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Triazoles | 2016 |
Chemosensitivity and Endocrine Sensitivity in Clinical Luminal Breast Cancer Patients in the Prospective Neoadjuvant Breast Registry Symphony Trial (NBRST) Predicted by Molecular Subtyping.
Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Bridged-Ring Compounds; Chemotherapy, Adjuvant; Clinical Decision-Making; Cyclophosphamide; Docetaxel; Doxorubicin; Female; Gene Expression Profiling; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Letrozole; Mastectomy, Segmental; Middle Aged; Molecular Typing; Neoadjuvant Therapy; Nitriles; Prospective Studies; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Registries; Tamoxifen; Taxoids; Treatment Outcome; Triazoles; Young Adult | 2017 |
Cost effectiveness of letrozole and purified urinary FSH in treating women with clomiphene citrate-resistant polycystic ovarian syndrome: a randomized controlled trial.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Cost-Benefit Analysis; Drug Therapy, Combination; Female; Fertility Agents, Female; Follicle Stimulating Hormone; Hormones; Humans; Infertility; Letrozole; Nitriles; Polycystic Ovary Syndrome; Pregnancy; Triazoles; Young Adult | 2017 |
Comparison of acupuncture pretreatment followed by letrozole versus letrozole alone on live birth in anovulatory infertile women with polycystic ovary syndrome: a study protocol for a randomised controlled trial.
Topics: Acupuncture Therapy; Adult; Aromatase Inhibitors; Birth Rate; Clinical Protocols; Electroacupuncture; Female; Humans; Infertility, Female; Insulin Resistance; Letrozole; Live Birth; Nitriles; Ovulation; Ovulation Induction; Polycystic Ovary Syndrome; Research Design; Triazoles; Young Adult | 2016 |
Effects of exemestane and letrozole therapy on plasma concentrations of estrogens in a randomized trial of postmenopausal women with breast cancer.
Topics: Androstadienes; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Estrogens; Female; Humans; Letrozole; Nitriles; Postmenopause; Treatment Outcome; Triazoles | 2017 |
Palbociclib and Letrozole in Advanced Breast Cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclin-Dependent Kinases; Disease-Free Survival; Double-Blind Method; Female; Humans; Letrozole; Middle Aged; Neutropenia; Nitriles; Piperazines; Postmenopause; Protein Kinase Inhibitors; Pyridines; Receptors, Estrogen; Triazoles | 2016 |
Ki67 Proliferation Index as a Tool for Chemotherapy Decisions During and After Neoadjuvant Aromatase Inhibitor Treatment of Breast Cancer: Results From the American College of Surgeons Oncology Group Z1031 Trial (Alliance).
Topics: Aged; Anastrozole; Androstadienes; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Clinical Decision-Making; Female; Follow-Up Studies; Humans; Ki-67 Antigen; Letrozole; Middle Aged; Mitotic Index; Neoadjuvant Therapy; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasm Staging; Nitriles; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Receptors, Estrogen; Receptors, Progesterone; Survival Rate; Transcriptome; Triazoles | 2017 |
Comparing the effect of aromatase inhibitor (letrozole) + cabergoline (Dostinex) and letrozole alone on uterine myoma regression,a randomized clinical trial.
Topics: Adult; Antineoplastic Agents; Aromatase Inhibitors; Cabergoline; Drug Therapy, Combination; Ergolines; Female; Humans; Leiomyoma; Letrozole; Middle Aged; Nitriles; Triazoles; Uterine Neoplasms; Uterus | 2017 |
Effects of a single 20 mg dose of letrozole on ovarian function post dominant follicle selection: an exploratory randomized controlled trial.
Topics: Adolescent; Adult; Aromatase Inhibitors; Body Mass Index; Endometrium; Female; Healthy Volunteers; Hormones; Humans; Letrozole; Luteinization; Menstrual Cycle; Nitriles; Ovarian Follicle; Ovary; Ovulation; Pilot Projects; Triazoles; Young Adult | 2017 |
Comparative Efficacy and Safety of Adjuvant Letrozole Versus Anastrozole in Postmenopausal Patients With Hormone Receptor-Positive, Node-Positive Early Breast Cancer: Final Results of the Randomized Phase III Femara Versus Anastrozole Clinical Evaluation
Topics: Aged; Anastrozole; Antineoplastic Agents, Hormonal; Arthralgia; Breast Neoplasms; Chemotherapy, Adjuvant; Depression; Disease-Free Survival; Dyspnea; Female; Hot Flashes; Humans; Hypertension; Letrozole; Lymphatic Metastasis; Mastectomy; Middle Aged; Myalgia; Neoplasm Staging; Nitriles; Postmenopause; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Survival Rate; Triazoles | 2017 |
The effect of estradiol on granulosa cell responses to FSH in women with polycystic ovary syndrome.
Topics: Adult; Aromatase Inhibitors; Cohort Studies; Estradiol; Female; Follicle Stimulating Hormone; Granulosa Cells; Humans; Inhibins; Letrozole; Nitriles; Polycystic Ovary Syndrome; Time Factors; Triazoles | 2017 |
Endocrine changes, fetal growth, and uterine artery hemodynamics after chronic estrogen suppression during the last trimester of equine pregnancy.
Topics: Animals; Aromatase Inhibitors; Estrogens; Female; Fetal Development; Hemodynamics; Horses; Letrozole; Nitriles; Pregnancy; Pregnancy, Animal; Triazoles; Uterine Artery; Uterus | 2017 |
Comparing the Administration of Letrozole and Megestrol Acetate in the Treatment of Women with Simple Endometrial Hyperplasia without Atypia: A Randomized Clinical Trial.
Topics: Administration, Oral; Adult; Endometrial Hyperplasia; Female; Humans; Letrozole; Megestrol Acetate; Middle Aged; Nitriles; Pilot Projects; Triazoles | 2017 |
Cholesterol, Cholesterol-Lowering Medication Use, and Breast Cancer Outcome in the BIG 1-98 Study.
Topics: Aged; Anticholesteremic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cholesterol; Disease-Free Survival; Double-Blind Method; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Letrozole; Mastectomy, Segmental; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Proportional Hazards Models; Radiotherapy, Adjuvant; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles | 2017 |
Prospective assessment of patient-reported outcomes and estradiol and drug concentrations in patients experiencing toxicity from adjuvant aromatase inhibitors.
Topics: Adult; Aged; Aged, 80 and over; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Cross-Over Studies; Estradiol; Female; Humans; Letrozole; Middle Aged; Nitriles; Patient Reported Outcome Measures; Prospective Studies; Random Allocation; Treatment Outcome; Triazoles | 2017 |
Phase 2 trial of everolimus and letrozole in relapsed estrogen receptor-positive high-grade ovarian cancers.
Topics: Administration, Oral; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Disease-Free Survival; Everolimus; Female; Humans; Letrozole; Mice; Mice, SCID; Middle Aged; Neoplasm Grading; Nitriles; Ovarian Neoplasms; Receptors, Estrogen; Triazoles; Xenograft Model Antitumor Assays | 2017 |
Comparison of clomiphene citrate and letrozole for ovulation induction in women with polycystic ovary syndrome: a prospective randomized trial.
Topics: Adult; Clomiphene; Female; Hormone Antagonists; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Prospective Studies; Triazoles; Young Adult | 2017 |
[Optimal Ovulation Induction in Polycystic Ovary Syndrome Resistant to Clomiphene Citrate or Letrozole.]
Topics: Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Menotropins; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Triazoles | 2016 |
Impact of nonsteroidal aromatase inhibitors on steroid profile in a Chinese population.
Topics: Aminoglutethimide; Anastrozole; Aromatase Inhibitors; Biomarkers, Pharmacological; Doping in Sports; Female; Hormones; Humans; Letrozole; Male; Models, Biological; Nitriles; Single-Blind Method; Steroids; Substance-Related Disorders; Triazoles; Young Adult | 2017 |
Stimulation of the ovaries in women with breast cancer undergoing fertility preservation: Alternative versus standard stimulation protocols; the study protocol of the STIM-trial.
Topics: Adolescent; Adult; Age Factors; Antineoplastic Agents; Body Mass Index; Breast Neoplasms; Estrogens; Female; Fertility Preservation; Follicle Stimulating Hormone; Humans; Letrozole; Nitriles; Oocytes; Ovulation Induction; Research Design; Socioeconomic Factors; Tamoxifen; Triazoles; Young Adult | 2017 |
Prognostic and predictive importance of the estrogen receptor coactivator AIB1 in a randomized trial comparing adjuvant letrozole and tamoxifen therapy in postmenopausal breast cancer: the Danish cohort of BIG 1-98.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Double-Blind Method; Female; Gene Expression Regulation, Neoplastic; Humans; Letrozole; Neoplasm Grading; Nitriles; Nuclear Receptor Coactivator 3; Postmenopause; Prognosis; Tamoxifen; Tissue Array Analysis; Treatment Outcome; Triazoles; Up-Regulation | 2017 |
Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial.
Topics: Administration, Oral; Bone Density Conservation Agents; Breast Neoplasms; Calcium, Dietary; Chemotherapy, Adjuvant; Cholecalciferol; Female; Humans; Letrozole; Middle Aged; Musculoskeletal Pain; Neoplasm Staging; Nitriles; Treatment Outcome; Triazoles | 2017 |
Double-blind randomized controlled trial of letrozole versus clomiphene citrate in subfertile women with polycystic ovarian syndrome.
Topics: Adult; Clomiphene; Double-Blind Method; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Time-to-Pregnancy; Treatment Outcome; Triazoles; Young Adult | 2017 |
Optimal Duration of Extended Adjuvant Endocrine Therapy for Early Breast Cancer; Results of the IDEAL Trial (BOOG 2006-05).
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Intraductal, Noninfiltrating; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Follow-Up Studies; Humans; Letrozole; Mastectomy, Segmental; Middle Aged; Neoplasm Recurrence, Local; Neoplasms, Second Primary; Nitriles; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Survival Rate; Tamoxifen; Time Factors; Triazoles | 2018 |
MONARCH 3: Abemaciclib As Initial Therapy for Advanced Breast Cancer.
Topics: Adult; Aged; Aged, 80 and over; Aminopyridines; Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Benzimidazoles; Biomarkers, Tumor; Breast Neoplasms; Double-Blind Method; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Receptor, ErbB-2; Survival Rate; Treatment Outcome; Triazoles | 2017 |
Ribociclib with letrozole vs letrozole alone in elderly patients with hormone receptor-positive, HER2-negative breast cancer in the randomized MONALEESA-2 trial.
Topics: Aged; Aged, 80 and over; Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Disease-Free Survival; Female; Humans; Letrozole; Middle Aged; Nitriles; Purines; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Triazoles | 2018 |
Neoadjuvant everolimus plus letrozole versus fluorouracil, epirubicin and cyclophosphamide for ER-positive, HER2-negative breast cancer: study protocol for a randomized pilot trial.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Chemotherapy, Adjuvant; China; Clinical Protocols; Cyclophosphamide; Epirubicin; Everolimus; Feasibility Studies; Female; Fluorouracil; Humans; Letrozole; Lymphatic Metastasis; Neoadjuvant Therapy; Nitriles; Pilot Projects; Postmenopause; Receptor, ErbB-2; Receptors, Estrogen; Research Design; Treatment Outcome; Triazoles; Tumor Burden | 2017 |
Clomiphene citrate combined with metformin versus letrozole for induction of ovulation in clomiphene-resistant polycystic ovary syndrome: a randomized clinical trial.
Topics: Adult; Clomiphene; Female; Fertility Agents, Female; Humans; Letrozole; Metformin; Nitriles; Ovulation; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Treatment Outcome; Triazoles; Young Adult | 2018 |
Evaluation of effect of letrozole prior to misoprostol in comparison with misoprostol alone in success rate of induced abortion.
Topics: Abortifacient Agents, Nonsteroidal; Abortion, Therapeutic; Adult; Aromatase Inhibitors; Case-Control Studies; Drug Therapy, Combination; Female; Humans; Letrozole; Misoprostol; Nitriles; Outcome Assessment, Health Care; Pregnancy; Triazoles | 2018 |
Extended adjuvant intermittent letrozole versus continuous letrozole in postmenopausal women with breast cancer (SOLE): a multicentre, open-label, randomised, phase 3 trial.
Topics: Aged; Antineoplastic Agents; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Time Factors; Treatment Outcome; Triazoles | 2018 |
Neoadjuvant letrozole for postmenopausal estrogen receptor-positive, HER2-negative breast cancer patients, a study from the Danish Breast Cancer Cooperative Group (DBCG).
Topics: Aged; Aged, 80 and over; Aromatase Inhibitors; Breast Neoplasms; Carcinoma, Ductal, Breast; Denmark; Female; Humans; Letrozole; Lymph Node Excision; Mastectomy; Mastectomy, Segmental; Middle Aged; Neoadjuvant Therapy; Nitriles; Postmenopause; Receptors, Estrogen; Triazoles | 2018 |
Intrauterine insemination with ovarian stimulation versus expectant management for unexplained infertility (TUI): a pragmatic, open-label, randomised, controlled, two-centre trial.
Topics: Administration, Oral; Adult; Clomiphene; Drug Administration Schedule; Female; Fertility Agents, Female; Fertilization in Vitro; Humans; Infertility, Female; Insemination, Artificial; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Outcome; Treatment Outcome; Triazoles; Watchful Waiting; Young Adult | 2018 |
Aurora kinase A as a possible marker for endocrine resistance in early estrogen receptor positive breast cancer.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Aurora Kinase A; Biomarkers; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Denmark; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Humans; Immunohistochemistry; Letrozole; Nitriles; Prognosis; Receptor, ErbB-2; Receptors, Estrogen; Tamoxifen; Triazoles | 2018 |
Combined effects of neoadjuvant letrozole and zoledronic acid on γδT cells in postmenopausal women with early-stage breast cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Diphosphonates; Female; Humans; Imidazoles; Intraepithelial Lymphocytes; Letrozole; Middle Aged; Neoadjuvant Therapy; Nitriles; Postmenopause; Prospective Studies; Receptor, ErbB-2; Receptors, Estrogen; Treatment Outcome; Triazoles; Zoledronic Acid | 2018 |
Palbociclib in combination with letrozole as first-line treatment for advanced breast cancer: A Japanese phase II study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Administration Schedule; Female; Humans; Letrozole; Middle Aged; Nitriles; Piperazines; Postmenopause; Pyridines; Survival Analysis; Treatment Outcome; Triazoles | 2018 |
Palbociclib has no clinically relevant effect on the QTc interval in patients with advanced breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Double-Blind Method; Electrocardiography; Female; Heart Rate; Humans; Letrozole; Middle Aged; Nitriles; Piperazines; Pyridines; Triazoles | 2018 |
The VEGF and PEDF levels in the follicular fluid of patients co- treated with LETROZOLE and gonadotropins during the stimulation cycle.
Topics: Adult; Aromatase Inhibitors; Drug Therapy, Combination; Eye Proteins; Female; Follicular Fluid; Gonadotropins; Humans; Infertility, Female; Letrozole; Male; Nerve Growth Factors; Nitriles; Ovulation Induction; Pregnancy; Prospective Studies; Serpins; Triazoles; Vascular Endothelial Growth Factor A | 2018 |
Cumulative incidence of cardiovascular events under tamoxifen and letrozole alone and in sequence: a report from the BIG 1-98 trial.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Cardiovascular Diseases; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Incidence; Letrozole; Nitriles; Postmenopause; Tamoxifen; Triazoles | 2021 |
Continuous versus intermittent extended adjuvant letrozole for breast cancer: final results of randomized phase III SOLE (Study of Letrozole Extension) and SOLE Estrogen Substudy.
Topics: Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Estrogens; Female; Humans; Letrozole; Nitriles; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles | 2021 |
The efficiency of low-dose letrozole plus clomiphene citrate for ovulation induction in intrauterine insemination cycles: A randomized clinical trial.
Topics: Chorionic Gonadotropin; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Insemination; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Triazoles | 2022 |
The Effect of Clomiphene Citrate and Letrozole in Apoptotic Pathways and Cell Cycle in Human Primary Cumulus Cells and the Protective Effect of Estradiol.
Topics: bcl-2-Associated X Protein; Cell Cycle; Clomiphene; Cumulus Cells; Estradiol; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Prospective Studies; Superoxide Dismutase; Triazoles | 2022 |
Ten-year update: NRG Oncology/National Surgical Adjuvant Breast and Bowel Project B-42 randomized trial: extended letrozole therapy in early-stage breast cancer.
Topics: Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Tamoxifen; Treatment Outcome; Triazoles | 2023 |
Comparing efficacy and safety of stair step protocols for clomiphene citrate and letrozole in ovulation induction for women with polycystic ovary syndrome (PCOS): a randomized controlled clinical trial.
Topics: Child; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Triazoles | 2023 |
1014 other study(ies) available for triazoles and letrozole
| Article | Year |
|---|---|
Inhibition of estrogen biosynthesis and its consequences on gonadotrophin secretion in the male.
Topics: Animals; Aromatase Inhibitors; Estradiol; Estrogen Antagonists; Fadrozole; Follicle Stimulating Hormone; Humans; Imidazoles; Letrozole; Luteinizing Hormone; Male; Nitriles; Organ Size; Rats; Reference Values; Testosterone; Triazoles | 1992 |
Effect of aromatase inhibitors on growth of mammary tumors in a nude mouse model.
Topics: Androstenedione; Animals; Antineoplastic Agents; Aromatase Inhibitors; Cell Division; Fadrozole; Female; Letrozole; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Nitriles; Organ Size; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles; Uterus | 1995 |
An in vivo model of intratumoural aromatase using aromatase-transfected MCF7 human breast cancer cells.
Topics: Animals; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Estradiol; Female; Humans; Letrozole; Male; Mice; Mice, Nude; Neoplasm Transplantation; Nitriles; Transfection; Transplantation, Heterologous; Triazoles | 1995 |
Role of reductase and aromatase in sex determination in the red-eared slider (Trachemys scripta), a turtle with temperature-dependent sex determination.
Topics: Animals; Aromatase; Aromatase Inhibitors; Azasteroids; Dihydrotestosterone; Dose-Response Relationship, Drug; Fadrozole; Female; Finasteride; Letrozole; Male; Nitriles; Oxidoreductases; Sex Determination Analysis; Sex Ratio; Temperature; Testosterone; Triazoles; Turtles | 1994 |
Changes induced by treatment with aromatase inhibitors in testicular Leydig cells of rats and dogs.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Dogs; Genitalia, Male; Letrozole; Leydig Cells; Male; Nitriles; Rats; Species Specificity; Triazoles | 1994 |
Development, application and comparison of an enzyme immunoassay and a high-performance liquid chromatography method for the determination of the aromatase inhibitor CGS 20,267 in biological fluids.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibody Specificity; Aromatase Inhibitors; Breast Neoplasms; Chromatography, High Pressure Liquid; Female; Guinea Pigs; Humans; Immunoenzyme Techniques; Letrozole; Male; Nitriles; Triazoles | 1994 |
The role of estrogen in the feedback regulation of follicle-stimulating hormone secretion in the female rat.
Topics: Animals; Aromatase Inhibitors; Estradiol; Estrogens; Feedback; Female; Follicle Stimulating Hormone; Homeostasis; Letrozole; Luteinizing Hormone; Nitriles; Organ Size; Ovariectomy; Ovary; Rats; Triazoles; Uterus | 1993 |
Estrogen synthesis inhibitors: from "off the rack" to haute couture.
Topics: Aromatase; Aromatase Inhibitors; Estrogens; Humans; Letrozole; Nitriles; Triazoles | 1993 |
Structure-activity relationships and binding model of novel aromatase inhibitors.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aromatase Inhibitors; Fadrozole; Female; Humans; Letrozole; Microsomes; Models, Molecular; Molecular Structure; Nitriles; Placenta; Pregnancy; Structure-Activity Relationship; Tetrazoles; Triazoles | 1993 |
Anti-tumor and endocrine effects of non-steroidal aromatase inhibitors on estrogen-dependent rat mammary tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Aromatase Inhibitors; Estradiol; Female; Letrozole; Luteinizing Hormone; Mammary Neoplasms, Experimental; Molecular Structure; Nitriles; Organ Size; Rats; Rats, Sprague-Dawley; Tetrazoles; Triazoles; Uterus | 1993 |
Making males from females: the effects of aromatase inhibitors on a parthenogenetic species of whiptail lizard.
Topics: Animals; Aromatase Inhibitors; Enzyme Inhibitors; Fadrozole; Female; Letrozole; Lizards; Male; Nitriles; Parthenogenesis; Sex Determination Analysis; Sex Differentiation; Triazoles | 1995 |
The ovary retains male potential after the thermosensitive period for sex determination in the turtle Emys orbicularis.
Topics: Analysis of Variance; Animals; Aromatase; Aromatase Inhibitors; Enzyme Inhibitors; Estrogens; Female; Letrozole; Male; Nitriles; Ovary; Sex Determination Analysis; Temperature; Testis; Triazoles; Turtles | 1996 |
Endocrine sex reversal of gonads by the aromatase inhibitor Letrozole (CGS 20267) in Emys orbicularis, a turtle with temperature-dependent sex determination.
Topics: Analysis of Variance; Animals; Enzyme Inhibitors; Female; Gonads; Letrozole; Nitriles; Pregnancy; Sex Differentiation; Triazoles; Turtles | 1995 |
High-performance liquid chromatography of the aromatase inhibitor, letrozole, and its metabolite in biological fluids with automated liquid-solid extraction and fluorescence detection.
Topics: Aromatase; Aromatase Inhibitors; Calibration; Chromatography, High Pressure Liquid; Circadian Rhythm; Enzyme Inhibitors; Fasting; Humans; Letrozole; Nitriles; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Triazoles | 1996 |
Paradoxical effect of an aromatase inhibitor, CGS 20267, on aromatase activity in guinea pig brain.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Binding, Competitive; Brain; Enzyme Inhibitors; Estradiol; Estrone; Guinea Pigs; Kinetics; Letrozole; Male; Microsomes; Nitriles; Orchiectomy; Testosterone; Triazoles | 1996 |
Oestrogen formation in breast: clinical and biological importance.
Topics: Androstenedione; Animals; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast; Breast Neoplasms; Estrogens; Female; Humans; Letrozole; Mice; Mice, Nude; Nitriles; Signal Transduction; Transfection; Triazoles; Tumor Cells, Cultured | 1996 |
Aromatase inhibitors come of age.
Topics: Aminoglutethimide; Anastrozole; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase III as Topic; Female; Humans; Letrozole; Nitriles; Triazoles | 1997 |
Effect of estrogen deprivation on the reproductive physiology of male and female primates.
Topics: Animals; Aromatase; Aromatase Inhibitors; Enzyme Inhibitors; Estrogen Antagonists; Estrogens; Fadrozole; Female; Letrozole; Macaca radiata; Male; Nitriles; Pregnancy; Reproduction; Triazoles | 1997 |
Regulation of aromatase activity within the breast.
Topics: Adipose Tissue; Aromatase; Aromatase Inhibitors; Breast; Breast Neoplasms; Enzyme Inhibitors; Female; Fibroblasts; Humans; Letrozole; Nitriles; Triazoles | 1997 |
Tamoxifen-resistant fibroblast growth factor-transfected MCF-7 cells are cross-resistant in vivo to the antiestrogen ICI 182,780 and two aromatase inhibitors.
Topics: Androstenedione; Animals; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Cell Division; Cell Line; Chloramphenicol O-Acetyltransferase; Drug Resistance, Neoplasm; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Female; Fibroblast Growth Factors; Fulvestrant; Humans; Letrozole; Luciferases; Mice; Mice, Nude; Nitriles; Ovariectomy; Polymerase Chain Reaction; Receptors, Progesterone; Recombinant Fusion Proteins; RNA, Messenger; Tamoxifen; Transcription, Genetic; Transfection; Transplantation, Heterologous; Triazoles; Tumor Cells, Cultured | 1998 |
Effect of CGS 20267 on ovarian aromatase and gonadotropin levels in the rat.
Topics: Animals; Antineoplastic Agents; Aromatase Inhibitors; Enzyme Inhibitors; Female; Gonadotropins, Pituitary; Letrozole; Nitriles; Organ Size; Ovary; Rats; Rats, Sprague-Dawley; Triazoles | 1998 |
Preclinical studies using the intratumoral aromatase model for postmenopausal breast cancer.
Topics: Anastrozole; Animals; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Drug Screening Assays, Antitumor; Endometrial Neoplasms; Enzyme Inhibitors; Estrogens; Female; Humans; Letrozole; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Neoplasms, Hormone-Dependent; Nitriles; Organ Size; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles; Tumor Cells, Cultured; Uterus | 1998 |
Toremifene and letrozole for advanced breast cancer.
Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Drug Interactions; Enzyme Inhibitors; Estrogen Antagonists; Female; Hot Flashes; Humans; Letrozole; Middle Aged; Nausea; Nitriles; Postmenopause; Toremifene; Triazoles | 1998 |
Letrozole for advanced breast cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Triazoles | 1998 |
Plasma protein binding of letrozole, a new nonsteroidal aromatase enzyme inhibitor.
Topics: Animals; Aromatase Inhibitors; Blood Proteins; Dialysis; Dogs; Enzyme Inhibitors; Erythrocytes; Estrogen Antagonists; Humans; Indicators and Reagents; Letrozole; Mice; Nitriles; Plasma; Protein Binding; Rabbits; Rats; Tamoxifen; Triazoles; Ultrafiltration | 1998 |
Intratumoral aromatase model: the effects of letrozole (CGS 20267).
Topics: Animals; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Mice; Mice, Inbred BALB C; Neoplasms, Hormone-Dependent; Nitriles; Tamoxifen; Triazoles; Tumor Cells, Cultured | 1998 |
The effects of aromatase inhibitors and antiestrogens in the nude mouse model.
Topics: Anastrozole; Animals; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Humans; Letrozole; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Nitriles; Tamoxifen; Triazoles; Tumor Cells, Cultured | 1998 |
The steroidal antiestrogen ICI 182,780 is an inhibitor of cellular aromatase activity.
Topics: Anastrozole; Androstenedione; Aromatase; Aromatase Inhibitors; Base Sequence; Breast Neoplasms; Cell Division; Cells, Cultured; Choriocarcinoma; DNA Primers; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Female; Fibroblasts; Fulvestrant; Humans; Letrozole; Microsomes; Nitriles; Placenta; RNA, Messenger; Triazoles; Tumor Cells, Cultured | 1998 |
Macrophages, estrogen and the microenvironment of breast cancer.
Topics: Antineoplastic Agents; Aromatase; Breast; Breast Neoplasms; Carcinoma in Situ; Cell Division; Cell Line; Enzyme Inhibitors; Estradiol; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hyperplasia; Immunohistochemistry; Letrozole; Macrophages; Monocytes; Nitriles; Placenta; Pregnancy; Testosterone; Tetradecanoylphorbol Acetate; Transcription, Genetic; Triazoles | 1998 |
[Metabolism of the androgenic precursor androstenedione and effects of aromatase inhibitors in cultured blood lymphocytes].
Topics: Adolescent; Adult; Age Factors; Aged; Androstenedione; Aromatase Inhibitors; Bucladesine; Cells, Cultured; Dexamethasone; Enzyme Inhibitors; Fadrozole; Female; Humans; Letrozole; Lymphocytes; Middle Aged; Nitriles; Triazoles | 1998 |
Letrozole: updated duration of response.
Topics: Antineoplastic Agents; Breast Neoplasms; Female; Humans; Letrozole; Megestrol Acetate; Nitriles; Postmenopause; Survival Analysis; Triazoles | 1999 |
The effect of combining aromatase inhibitors with antiestrogens on tumor growth in a nude mouse model for breast cancer.
Topics: Analysis of Variance; Anastrozole; Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase; Aromatase Inhibitors; Disease Models, Animal; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Humans; Letrozole; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Nitriles; Tamoxifen; Time Factors; Triazoles; Tumor Cells, Cultured | 1999 |
Cost effectiveness of letrozole in the treatment of advanced breast cancer in postmenopausal women in the UK.
Topics: Antineoplastic Agents; Breast Neoplasms; Computer Simulation; Cost-Benefit Analysis; Female; Humans; Letrozole; Markov Chains; Models, Biological; Models, Economic; Nitriles; Postmenopause; Triazoles; United Kingdom | 1999 |
The role of estrogen in the maintenance of primate pregnancy.
Topics: Animals; Aromatase Inhibitors; Cesarean Section; Enzyme Inhibitors; Estradiol; Female; Letrozole; Luminescent Measurements; Male; Nitriles; Papio; Pregnancy; Pregnancy, Animal; Progesterone; Radioimmunoassay; Random Allocation; Triazoles | 2000 |
Biology of aromatase inhibitors: pharmacology/endocrinology within the breast.
Topics: Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast; Breast Neoplasms; Cells, Cultured; Enzyme Inhibitors; Estrogens; Female; Fibroblasts; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Triazoles; Tumor Cells, Cultured | 1999 |
Aromatase overexpression and breast hyperplasia, an in vivo model--continued overexpression of aromatase is sufficient to maintain hyperplasia without circulating estrogens, and aromatase inhibitors abrogate these preneoplastic changes in mammary glands.
Topics: Animals; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Estrogens; Female; Hyperplasia; Letrozole; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Neoplasms, Hormone-Dependent; Nitriles; Ovariectomy; Precancerous Conditions; Receptors, Estrogen; Triazoles | 1999 |
Letrozole: which dose to be used?
Topics: Antineoplastic Agents; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Postmenopause; Triazoles | 2000 |
Letrozole for the treatment of pretreated advanced breast cancer patients: preliminary report.
Topics: Administration, Oral; Adult; Antineoplastic Agents; Breast Neoplasms; Female; Humans; Letrozole; Middle Aged; Neoplasm Metastasis; Nitriles; Postmenopause; Premenopause; Salvage Therapy; Treatment Outcome; Triazoles | 2000 |
[Aromatase inhibitors in the treatment of breast cancer].
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Triazoles | 2000 |
Cost-utility analysis of second-line hormonal therapy in advanced breast cancer: a comparison of two aromatase inhibitors to megestrol acetate.
Topics: Anastrozole; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Canada; Costs and Cost Analysis; Decision Support Techniques; Female; Humans; Letrozole; Megestrol Acetate; Nitriles; Quality of Life; Randomized Controlled Trials as Topic; Triazoles | 2000 |
An overview of the use of non-steroidal aromatase inhibitors in the treatment of breast cancer.
Topics: Anastrozole; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Triazoles | 2000 |
FDA panel recommends two new cancer drugs for approval.
Topics: Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neoplasm; Antineoplastic Agents; Aromatase Inhibitors; Clinical Trials as Topic; Disease-Free Survival; Drug Approval; Enzyme Inhibitors; Humans; Letrozole; Nitriles; Triazoles; United States; United States Food and Drug Administration | 2001 |
From the Food and Drug Administration.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Colitis, Ulcerative; Dermatologic Agents; Humans; Information Services; Isotretinoin; Letrozole; Mesalamine; Nitriles; Risk; Suppositories; Triazoles; United States; United States Food and Drug Administration | 2001 |
The Twenty-third Annual San Antonio Breast Cancer Symposium.
Topics: Anastrozole; Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Capecitabine; Combined Modality Therapy; Deoxycytidine; Estradiol; Estrogen Antagonists; Female; Fluorouracil; Fulvestrant; Humans; Letrozole; Male; Mastectomy; Nitriles; Prognosis; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles | 2001 |
Developmental regulation of morphological differentiation of placental villous trophoblast in the baboon.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Bromodeoxyuridine; Cell Differentiation; Enzyme Inhibitors; Estradiol; Estrogens; Female; Ki-67 Antigen; Letrozole; Nitriles; Papio; Placenta; Pregnancy; Triazoles; Trophoblasts | 2001 |
Use of a specific aromatase inhibitor in delayed puberty.
Topics: Adolescent; Aromatase Inhibitors; Estradiol; Humans; Letrozole; Male; Nitriles; Puberty, Delayed; Testosterone; Triazoles | 2001 |
Gender difference in letrozole pharmacokinetics in rats.
Topics: Animals; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Enzyme Inhibitors; Female; Letrozole; Male; Nitriles; Rats; Rats, Sprague-Dawley; Sex Factors; Tissue Distribution; Triazoles | 2000 |
Effect of letrozole on the lipid profile in postmenopausal women with breast cancer.
Topics: Aged; Antineoplastic Agents; Apolipoprotein A-I; Apolipoproteins B; Apolipoproteins E; Breast Neoplasms; Cholesterol, HDL; Cholesterol, LDL; Enzyme Inhibitors; Female; Humans; Letrozole; Lipids; Lipoprotein(a); Middle Aged; Nitriles; Postmenopause; Risk Factors; Triazoles; Triglycerides | 2001 |
Endometrial stromal sarcoma: objective response to letrozole.
Topics: Abdominal Neoplasms; Antineoplastic Agents; Endometrial Neoplasms; Female; Humans; Letrozole; Liver Neoplasms; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Pelvic Neoplasms; Sarcoma, Endometrial Stromal; Triazoles | 2001 |
Sex reversal and aromatase in the European pond turtle: treatment with letrozole after the thermosensitive period for sex determination.
Topics: Animals; Aromatase; Aromatase Inhibitors; Disorders of Sex Development; Female; Letrozole; Male; Nitriles; Ovary; Sex Differentiation; Temperature; Testis; Triazoles; Turtles | 2001 |
Use of ErbB-1 and ErbB-2 to select endocrine therapy for breast cancer: will it play in Peoria?
Topics: Antineoplastic Agents; Breast Neoplasms; ErbB Receptors; Estrogen Antagonists; Female; Humans; Letrozole; Neoadjuvant Therapy; Nitriles; Predictive Value of Tests; Receptor, ErbB-2; Tamoxifen; Triazoles | 2001 |
Developmental maturation of primate placental trophoblast: placental cytosolic and secretory phospholipase A2 expression after estrogen suppression of baboons.
Topics: Animals; Enzyme Inhibitors; Estrogens; Female; Gene Expression Regulation, Enzymologic; Letrozole; Nitriles; Papio; Phospholipases A; Phospholipases A2; Pregnancy; RNA, Messenger; Triazoles; Trophoblasts | 2001 |
Aromatase inhibitors: treatment of advanced breast cancer.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Bone Density; Breast Neoplasms; Female; Humans; Letrozole; Middle Aged; Nitriles; Osteoporosis, Postmenopausal; Randomized Controlled Trials as Topic; Triazoles | 2001 |
Inhibition of P450 aromatase enhances gonadotropin secretion in early and midpubertal boys: evidence for a pituitary site of action of endogenous E.
Topics: Adolescent; Aromatase Inhibitors; Enzyme Inhibitors; Estradiol; Estrogens; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Humans; Inhibins; Letrozole; Luteinizing Hormone; Male; Nitriles; Pituitary Gland; Puberty; Testosterone; Triazoles | 2001 |
Aromatase inhibitors and inactivators in breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Estrogen Antagonists; Estrogens; Female; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles | 2001 |
Role of hormones in puberty.
Topics: Body Height; Child; Enzyme Inhibitors; Female; Gonadal Steroid Hormones; Growth; Humans; Letrozole; Male; Nitriles; Puberty, Delayed; Testosterone; Triazoles | 2001 |
Letrozole in second-line therapy of advanced breast cancer: more questions than answers.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Canada; Clinical Trials, Phase III as Topic; Drug Administration Schedule; Europe; Female; Humans; Letrozole; Megestrol Acetate; Neoplasm Metastasis; Nitriles; Palliative Care; Postmenopause; Treatment Outcome; Triazoles | 2001 |
False shortening of time to progression in letrozole 2.5-mg dose?
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Disease Progression; Dose-Response Relationship, Drug; Female; Humans; Letrozole; Nitriles; Triazoles | 2001 |
[Neoadjuvant use of the aromatase inhibitor letrozole in uterine cancer: endocrine and clinical effects].
Topics: Antineoplastic Agents; Aromatase Inhibitors; Blood Glucose; Chemotherapy, Adjuvant; Enzyme Inhibitors; Estradiol; Female; Follicle Stimulating Hormone; Humans; Letrozole; Luteinizing Hormone; Nitriles; Receptors, Progesterone; Treatment Outcome; Triazoles; Uterine Neoplasms | 2001 |
New breast cancer drug.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Estrogens; Female; Humans; Letrozole; Nitriles; Postmenopause; Recurrence; Triazoles; United States | 2001 |
Superior efficacy of letrozole versus tamoxifen as first-line therapy.
Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Postmenopause; Tamoxifen; Triazoles | 2002 |
Pre-operative endocrine therapy for postmenopausal women: when and why?
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Postmenopause; Preoperative Care; Randomized Controlled Trials as Topic; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Treatment Outcome; Triazoles | 2001 |
Formestane, a steroidal aromatase inhibitor after failure of non-steroidal aromatase inhibitors (anastrozole and letrozole): is a clinical benefit still achievable?
Topics: Adult; Aged; Anastrozole; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Disease Progression; Enzyme Inhibitors; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Receptors, Estrogen; Retrospective Studies; Treatment Failure; Triazoles | 2001 |
[Growth rate can be manipulated. Estrogen production in pubertal boys can be blocked by an aromatase inhibitor].
Topics: Age Determination by Skeleton; Aromatase Inhibitors; Body Height; Child; Controlled Clinical Trials as Topic; Enzyme Inhibitors; Estrogens; Gonadotropins; Growth; Humans; Letrozole; Male; Nitriles; Puberty, Delayed; Receptors, Estrogen; Reference Values; Testosterone; Triazoles | 2002 |
Aromatase overexpression transgenic mice model: cell type specific expression and use of letrozole to abrogate mammary hyperplasia without affecting normal physiology.
Topics: Animals; Aromatase; Aromatase Inhibitors; Enzyme Inhibitors; Epithelial Cells; Estradiol; Estrogens; Female; Follicle Stimulating Hormone; Gene Expression; Hyperplasia; Letrozole; Male; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Nitriles; RNA, Messenger; Stromal Cells; Tissue Distribution; Triazoles | 2001 |
Aromatase and COX-2 expression in human breast cancers.
Topics: Adipocytes; Adult; Aged; Aged, 80 and over; Animals; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Cyclooxygenase 2; Dinoprostone; Endothelium; Enzyme Inhibitors; Epithelial Cells; Estrogen Receptor Modulators; Estrogens; Female; Humans; Immunohistochemistry; Isoenzymes; Letrozole; Mammary Neoplasms, Experimental; Membrane Proteins; Mice; Mice, Inbred BALB C; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Prostaglandin-Endoperoxide Synthases; Stromal Cells; Tamoxifen; Triazoles | 2001 |
Local endocrine effects of aromatase inhibitors within the breast.
Topics: Anastrozole; Androstadienes; Aromatase; Aromatase Inhibitors; Breast; Breast Neoplasms; Cells, Cultured; Chemotherapy, Adjuvant; Enzyme Inhibitors; Estrogens; Estrone; Female; Fibroblasts; Humans; In Vitro Techniques; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Triazoles | 2001 |
Biological and clinical effects of aromatase inhibitors in neoadjuvant therapy.
Topics: Anastrozole; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Enzyme Inhibitors; Estrogen Receptor Modulators; Female; Humans; Immunohistochemistry; Ki-67 Antigen; Letrozole; Menopause; Neoplasms, Hormone-Dependent; Nitriles; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles | 2001 |
17alpha-methyl testosterone is a competitive inhibitor of aromatase activity in Jar choriocarcinoma cells and macrophage-like THP-1 cells in culture.
Topics: Aromatase; Aromatase Inhibitors; Binding, Competitive; Cell Line; Choriocarcinoma; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Kinetics; Letrozole; Macrophages; Methyltestosterone; Nitriles; Transcription, Genetic; Triazoles; Tumor Cells, Cultured; Uterine Neoplasms | 2001 |
[Aromatase inhibitors of the 3rd generation. What can the "pill against breast cancer" really do?].
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase III as Topic; Enzyme Inhibitors; Humans; Letrozole; Nitriles; Triazoles | 2002 |
Approval summary: letrozole in the treatment of postmenopausal women with advanced breast cancer.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Drug Approval; Enzyme Inhibitors; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Tamoxifen; Treatment Outcome; Triazoles; United States; United States Food and Drug Administration | 2002 |
Breast cancer studies challenge tamoxifen therapy.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles | 2000 |
New breast cancer drugs expand treatment options.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles | 2002 |
Short-term effects of anastrozole treatment on insulin-like growth factor system in postmenopausal advanced breast cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Letrozole; Middle Aged; Nitriles; Postmenopause; Time Factors; Triazoles | 2002 |
Endocrine effects of nonsteroidal aromatase inhibitors and their clinical impact.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Cross-Over Studies; Enzyme Inhibitors; Estrogens; Female; Humans; Letrozole; Nitriles; Postmenopause; Research Design; Triazoles | 2002 |
Estrogen as therapy for breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Breast Neoplasms; Clinical Trials, Phase II as Topic; Diethylstilbestrol; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Estrogens; Female; Humans; Letrozole; Megestrol Acetate; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Salvage Therapy; Tamoxifen; Treatment Outcome; Triazoles | 2002 |
Genetic or enzymatic disruption of aromatase inhibits the growth of ectopic uterine tissue.
Topics: Animals; Aromatase; Aromatase Inhibitors; Cell Division; Choristoma; Endometriosis; Enzyme Inhibitors; Estrogens; Female; Growth; Letrozole; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitriles; Triazoles; Uterus | 2002 |
Promising results for Arimidex and Femara.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Breast Neoplasms; Clinical Trials, Phase III as Topic; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles | 2001 |
The effect of second-line antiestrogen therapy on breast tumor growth after first-line treatment with the aromatase inhibitor letrozole: long-term studies using the intratumoral aromatase postmenopausal breast cancer model.
Topics: Animals; Aromatase; Aromatase Inhibitors; Disease Models, Animal; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Humans; In Vitro Techniques; Letrozole; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Hormone-Dependent; Nitriles; Receptors, Estrogen; Tamoxifen; Triazoles; Tumor Cells, Cultured | 2002 |
Reversible pancytopenia caused by oral letrozole assumption in a patient with recurrent breast cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Female; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Pancytopenia; Triazoles | 2002 |
Developmental regulation of baboon fetal ovarian maturation by estrogen.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Enzyme Inhibitors; Epithelium; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Female; Fetal Blood; Gestational Age; Letrozole; Mesoderm; Nitriles; Organ Size; Ovary; Papio; Pregnancy; Receptors, Estrogen; Testosterone; Triazoles | 2002 |
Neoadjuvant therapy of endometrial cancer with the aromatase inhibitor letrozole: endocrine and clinical effects.
Topics: Aged; Aromatase Inhibitors; Endometrial Neoplasms; Enzyme Inhibitors; Estradiol; Female; Follicle Stimulating Hormone; Humans; Letrozole; Luteinizing Hormone; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Nitriles; Postmenopause; Receptors, Progesterone; Treatment Outcome; Triazoles; Ultrasonography | 2002 |
Developmental, estrogen induced infravesical obstruction is reversible in adult male rodents.
Topics: Animals; Animals, Newborn; Aromatase; Aromatase Inhibitors; Electromyography; Estrogens; Letrozole; Male; Mice; Mice, Transgenic; Nitriles; Rats; Seminal Vesicles; Testosterone; Triazoles; Urethra; Urethral Obstruction; Urodynamics | 2002 |
Estrogens, but not androgens, regulate expression and functional activity of oxytocin receptor in rabbit epididymis.
Topics: Androgens; Animals; Aromatase Inhibitors; Blotting, Northern; Blotting, Western; Enzyme Inhibitors; Epididymis; Estradiol; Estrogen Antagonists; Estrogens; Gene Expression Regulation; Hypogonadism; Letrozole; Male; Nitriles; Oxytocin; Rabbits; Receptors, Oxytocin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tamoxifen; Testosterone; Triazoles; Triptorelin Pamoate | 2002 |
Letrozole's superiority over progestins and tamoxifen challenges standards of care in endocrine therapy for metastatic breast cancer.
Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Letrozole; Neoplasm Metastasis; Nitriles; Progestins; Randomized Controlled Trials as Topic; Tamoxifen; Treatment Outcome; Triazoles | 2002 |
Current role of endocrine therapy in the management of breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Estrogen Receptor Modulators; Female; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles | 2002 |
Fetal lung maturation in estrogen-deprived baboons.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Animals; Aromatase Inhibitors; Embryonic and Fetal Development; Enzyme Inhibitors; Estradiol; Estrogens; Female; Fetal Blood; Fetal Organ Maturity; Fetus; Hydrocortisone; Hydroxysteroid Dehydrogenases; Letrozole; Lung; Nitriles; Papio; Pregnancy; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Protein B; Triazoles | 2003 |
Letrozole as a potent inhibitor of cell proliferation and expression of metalloproteinases (MMP-2 and MMP-9) by human epithelial breast cancer cells.
Topics: Breast Neoplasms; Cell Division; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Hormones; Humans; Letrozole; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Nitriles; RNA, Messenger; Triazoles; Tumor Cells, Cultured | 2003 |
Expression of functional estrogen receptors in human fetal male external genitalia.
Topics: Aromatase Inhibitors; Blotting, Western; Cell Division; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptor beta; Genitalia, Male; Gestational Age; Humans; Immunohistochemistry; Letrozole; Male; Metribolone; Muscle, Smooth; Nitriles; Penis; Polymerase Chain Reaction; Receptors, Androgen; Receptors, Estrogen; Receptors, Progesterone; Reverse Transcriptase Polymerase Chain Reaction; Tamoxifen; Testosterone; Testosterone Congeners; Triazoles | 2003 |
A stochastic economic evaluation of letrozole versus tamoxifen as a first-line hormonal therapy: for advanced breast cancer in postmenopausal patients.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase III as Topic; Cost-Benefit Analysis; Female; Humans; Letrozole; Markov Chains; Models, Biological; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Stochastic Processes; Tamoxifen; Triazoles | 2003 |
Estrogen and antiestrogen effects on neonatal ovine uterine development.
Topics: Animals; Animals, Newborn; Aromatase Inhibitors; Benzopyrans; Cell Differentiation; Endometrium; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogens; Female; Immunohistochemistry; In Situ Hybridization; Letrozole; Nitriles; Pregnancy; Propionates; Radioimmunoassay; Receptors, Estrogen; RNA, Messenger; Sheep; Stromal Cells; Triazoles; Uterus | 2003 |
Pathological features of breast cancer response following neoadjuvant treatment with either letrozole or tamoxifen.
Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Apoptosis; Breast Neoplasms; Cell Division; Chemotherapy, Adjuvant; Female; Humans; Ki-67 Antigen; Letrozole; Nitriles; Postmenopause; Tamoxifen; Triazoles | 2003 |
New approaches to the understanding of tamoxifen action and resistance.
Topics: Animals; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Drug Resistance, Neoplasm; Estradiol; Farnesol; Female; Humans; Immunoenzyme Techniques; Letrozole; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Neoplasm Transplantation; Nitriles; Receptors, Estrogen; Salicylates; Tamoxifen; Triazoles; Tumor Cells, Cultured | 2003 |
Cost utility analysis of first-line hormonal therapy in advanced breast cancer: comparison of two aromatase inhibitors to tamoxifen.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Canada; Cost-Benefit Analysis; Decision Support Techniques; Enzyme Inhibitors; Humans; Letrozole; Meta-Analysis as Topic; Nitriles; Quality of Life; Tamoxifen; Triazoles | 2003 |
Durable remission of leptomeningeal metastasis of breast cancer with letrozole: a case report and implications of biomarkers on treatment selection.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Lobular; Chemotherapy, Adjuvant; Cranial Irradiation; Female; Humans; Letrozole; Lymphatic Metastasis; Meningeal Neoplasms; Middle Aged; Nitriles; Remission Induction; Survivors; Treatment Outcome; Triazoles | 2003 |
[Hormone therapy, chemotherapy and immunotherapy in breast carcinoma. The best strategy for your patient].
Topics: Adult; Age Factors; Aged; Anastrozole; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Enzyme Inhibitors; Estrogen Antagonists; Female; Humans; Immunotherapy; Letrozole; Meta-Analysis as Topic; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Nitriles; Premenopause; Prognosis; Quality of Health Care; Raloxifene Hydrochloride; Randomized Controlled Trials as Topic; Risk Factors; Selective Estrogen Receptor Modulators; Tamoxifen; Time Factors; Toremifene; Trastuzumab; Triazoles | 2003 |
Aromatase inhibition reduces gonadotrophin dose required for controlled ovarian stimulation in women with unexplained infertility.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Enzyme Inhibitors; Estradiol; Female; Fertility Agents, Female; Follicle Stimulating Hormone, Human; Humans; Infertility, Female; Letrozole; Luteinizing Hormone; Nitriles; Ovarian Follicle; Ovulation Induction; Pilot Projects; Pregnancy; Prospective Studies; Triazoles; Ultrasonography | 2003 |
Economic evaluation of antiaromatase agents in the second-line treatment of metastatic breast cancer.
Topics: Aged; Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Canada; Clinical Trials, Phase III as Topic; Cost-Benefit Analysis; Enzyme Inhibitors; Female; Humans; Letrozole; Megestrol; Middle Aged; Nitriles; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Survival Analysis; Triazoles | 2003 |
Role of biologic markers in patient selection and application to disease prevention.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Biomarkers; Bone Density; Breast Neoplasms; Enzyme Inhibitors; ErbB Receptors; Estradiol; Female; Humans; Letrozole; Nitriles; Patient Selection; Postmenopause; Prognosis; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Risk Factors; Tamoxifen; Triazoles | 2003 |
Examining quality of life issues in relation to endocrine therapy for breast cancer.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Decision Making; Enzyme Inhibitors; Estrogen Antagonists; Female; Humans; Letrozole; Nitriles; Quality of Life; Tamoxifen; Triazoles | 2003 |
Doctors in India prescribe unapproved fertility drug.
Topics: Drug Approval; Drug Labeling; Female; Fertility Agents, Female; Humans; India; Infertility, Female; Letrozole; Nitriles; Triazoles | 2003 |
Letrozole after tamoxifen for breast cancer--what is the price of success?
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles | 2003 |
Beyond tamoxifen--extending endocrine treatment for early-stage breast cancer.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles | 2003 |
Indian firm caught marketing anticancer drug for fertility.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Drug Approval; Drug Industry; Enzyme Inhibitors; Female; Government Regulation; Humans; India; Infertility, Female; Letrozole; Nitriles; Triazoles | 2003 |
Estrogen-induced neurochemical and electrophysiological changes in the parabrachial nucleus of the male rat.
Topics: Animals; Autonomic Nervous System; Electrophysiology; Enzyme Inhibitors; Estradiol; Estrogens; Excitatory Amino Acids; Hemodynamics; Letrozole; Male; Microdialysis; Microinjections; Neurons; Neurotransmitter Agents; Nitriles; Pons; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Testosterone; Triazoles | 2003 |
Alopecia in a premenopausal breast cancer woman treated with letrozole and triptorelin.
Topics: Adult; Alopecia; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Hormones; Humans; Letrozole; Nitriles; Premenopause; Triazoles; Triptorelin Pamoate | 2003 |
Searching for the next tamoxifen.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Research; Tamoxifen; Triazoles; United States | 2003 |
Response of estrogen receptor-positive intraabdominal fibromatosis to aromatase inhibitor therapy.
Topics: Aromatase Inhibitors; Female; Fibromatosis, Abdominal; Humans; Letrozole; Middle Aged; Nitriles; Receptors, Estrogen; Receptors, Progesterone; Tomography, X-Ray Computed; Triazoles | 2003 |
Indian drug firm accused of illegal marketing of letrozole.
Topics: Drug Approval; Female; Fertility Agents, Female; Humans; India; Infertility, Female; Legislation, Drug; Letrozole; Nitriles; Triazoles | 2003 |
The intratumoral aromatase model: studies with aromatase inhibitors and antiestrogens.
Topics: Androstadienes; Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Cell Line, Tumor; Disease Models, Animal; Drug Administration Schedule; Enzyme Inhibitors; Estrogen Antagonists; Female; Humans; Letrozole; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Neoplasms, Hormone-Dependent; Nitriles; Tamoxifen; Treatment Outcome; Triazoles | 2003 |
Use of letrozole as a chemopreventive agent in aromatase overexpressing transgenic mice.
Topics: Animals; Anticarcinogenic Agents; Aromatase; Aromatase Inhibitors; Birth Weight; Female; Hyperplasia; Lactation; Letrozole; Male; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Nitriles; Pregnancy; Receptors, Estrogen; RNA, Messenger; Tamoxifen; Triazoles | 2003 |
Dehydroepiandrosterone increases hippocampal spine synapse density in ovariectomized female rats.
Topics: Adjuvants, Immunologic; Animals; Dehydroepiandrosterone; Dendrites; Enzyme Inhibitors; Estrogens; Female; Hippocampus; Letrozole; Nitriles; Ovariectomy; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Synapses; Triazoles | 2004 |
Critics question price of success in halted clinical trial of aromatase inhibitor letrozole.
Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Controlled Clinical Trials as Topic; Disease-Free Survival; Enzyme Inhibitors; Estrogen Receptor Modulators; Ethics, Research; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Single-Blind Method; Survival Analysis; Tamoxifen; Time Factors; Treatment Outcome; Triazoles; United States | 2003 |
Hormonal therapy: introduction.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chemotherapy, Adjuvant; Controlled Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Letrozole; Nitriles; Prognosis; Risk Assessment; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles; United Kingdom | 2003 |
Effects of letrozole on superovulation with gonadotropins in women undergoing intrauterine insemination.
Topics: Adult; Aromatase Inhibitors; Chorionic Gonadotropin; Enzyme Inhibitors; Female; Hospitals, Teaching; Humans; Insemination, Artificial; Letrozole; Nitriles; Pregnancy; Pregnancy Outcome; Retrospective Studies; Superovulation; Triazoles | 2003 |
Comparison of the effects of letrozole and clomiphene citrate on ovarian follicles, endometrium, and hormone levels in the rat.
Topics: Animals; Cell Count; Clomiphene; Endometrium; Estradiol; Female; Fertility Agents, Female; Follicle Stimulating Hormone; Letrozole; Luteinizing Hormone; Nitriles; Ovarian Follicle; Rats; Rats, Wistar; Reference Values; Testosterone; Triazoles | 2003 |
Letrozole: ovulation or superovulation?
Topics: Aromatase; Enzyme Inhibitors; Female; Humans; Letrozole; Models, Biological; Nitriles; Ovulation; Superovulation; Triazoles | 2003 |
Breast-cancer drug letrozole picks up where tamoxifen leaves off. But we don't know who stands to benefit the most from this follow-up approach.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Triazoles | 2003 |
Top 10 health stories of 2003.
Topics: Aging; Angioplasty, Balloon, Coronary; Antineoplastic Agents; Breast Neoplasms; Dietary Carbohydrates; Disease Outbreaks; Genome, Human; Guideline Adherence; Hormone Replacement Therapy; Humans; Hypertension; Letrozole; Myocardial Infarction; Nitriles; Obesity; Public Health; Severe Acute Respiratory Syndrome; Triazoles | 2003 |
Oxytocin receptor is expressed in the penis and mediates an estrogen-dependent smooth muscle contractility.
Topics: Animals; Aromatase Inhibitors; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrogens; Gonadotropin-Releasing Hormone; Humans; Hypogonadism; In Vitro Techniques; Letrozole; Male; Muscle Contraction; Muscle, Smooth; Nitriles; Osmolar Concentration; Oxytocin; Penis; Rabbits; Receptors, Oxytocin; Tamoxifen; Triazoles; Triptorelin Pamoate | 2004 |
Benefit of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Combined Modality Therapy; Female; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Tamoxifen; Treatment Outcome; Triazoles | 2003 |
Treatment of severe recurrent endometriosis with an aromatase inhibitor in a young ovariectomised woman.
Topics: Administration, Oral; Adult; Aromatase Inhibitors; Dyspareunia; Endometriosis; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Ovarian Diseases; Ovariectomy; Pelvic Pain; Peritoneal Diseases; Secondary Prevention; Triazoles | 2004 |
Androgens increase spine synapse density in the CA1 hippocampal subfield of ovariectomized female rats.
Topics: Animals; Aromatase Inhibitors; Dendrites; Dihydrotestosterone; Enzyme Inhibitors; Female; Hippocampus; Letrozole; Nitriles; Ovariectomy; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Synapses; Testosterone; Testosterone Propionate; Triazoles | 2004 |
Letrozole in breast cancer.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Disease-Free Survival; Female; Humans; Letrozole; Nitriles; Postmenopause; Tamoxifen; Triazoles | 2004 |
Letrozole in breast cancer.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Triazoles | 2004 |
Letrozole in breast cancer.
Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Enzyme Inhibitors; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Research Design; Tamoxifen; Time Factors; Triazoles | 2004 |
Letrozole in breast cancer.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Tamoxifen; Triazoles | 2004 |
Letrozole in breast cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles | 2004 |
Drugs may improve long-term outcomes after breast cancer.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles | 2004 |
New treatment boosts outlook for breast cancer survivors.
Topics: Antineoplastic Agents; Breast Neoplasms; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Tamoxifen; Triazoles | 2004 |
Role of endocrine therapy in the neoadjuvant surgical setting.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Nitriles; Patient Selection; Tamoxifen; Treatment Outcome; Triazoles | 2004 |
Therapeutic strategies using the aromatase inhibitor letrozole and tamoxifen in a breast cancer model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Disease Models, Animal; Disease Progression; Drug Administration Schedule; Enzyme Inhibitors; Estrogen Receptor Modulators; Female; Humans; Letrozole; Linear Models; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Hormone-Dependent; Nitriles; Organ Size; Ovariectomy; Tamoxifen; Transplantation, Heterologous; Triazoles; Uterus | 2004 |
[Complete remission obtained with letrozole in a man with metastatic breast cancer].
Topics: Aged; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms, Male; Humans; Letrozole; Male; Neoplasm Metastasis; Nitriles; Remission Induction; Treatment Outcome; Triazoles | 2004 |
Changes in vascular endothelial growth factor (VEGF) after chemoendocrine therapy in breast cancer.
Topics: Androstadienes; Angiopoietin-1; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; DNA Primers; Docetaxel; Dose-Response Relationship, Drug; Doxorubicin; Female; Gene Expression Regulation, Neoplastic; Humans; Letrozole; Neovascularization, Pathologic; Nitriles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Tamoxifen; Taxoids; Triazoles; Vascular Endothelial Growth Factor A | 2004 |
Does letrozole have any place in adjuvant setting in breast cancer patients with documented hypercoagulability?
Topics: Aged; Anticoagulants; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Contraindications; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Pulmonary Embolism; Risk; Tamoxifen; Triazoles; Venous Thrombosis; Warfarin | 2004 |
Aromatase inhibitors and teratogenesis.
Topics: Animals; Aromatase Inhibitors; Enzyme Inhibitors; Female; Letrozole; Nitriles; Ovulation Induction; Teratogens; Triazoles | 2004 |
Long-term insurance for breast cancer survivors.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Insurance, Long-Term Care; Letrozole; Nitriles; Tamoxifen; Triazoles | 2004 |
Comment on "Anastrozole (Arimidex) versus tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women: survival analysis and updated safety results" by J.-M. Nabholtz et al.
Topics: Anastrozole; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Letrozole; Nitriles; Postmenopause; Survival Analysis; Tamoxifen; Triazoles | 2004 |
Aromatase inhibition, testosterone, and seizures.
Topics: Anticonvulsants; Aromatase Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephalography; Epilepsy, Temporal Lobe; Erectile Dysfunction; Estradiol; Follicle Stimulating Hormone; Humans; Letrozole; Levetiracetam; Libido; Luteinizing Hormone; Male; Middle Aged; Nitriles; Piracetam; Quality of Life; Sex Hormone-Binding Globulin; Testosterone; Triazoles | 2004 |
Comparison of two aromatase inhibitors in women with clomiphene-resistant polycystic ovary syndrome.
Topics: Adult; Anastrozole; Aromatase Inhibitors; Clomiphene; Estrogen Antagonists; Female; Humans; Letrozole; Nitriles; Ovulation; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Triazoles | 2004 |
Dynamic contrast enhanced magnetic resonance imaging in monitoring bone metastases in breast cancer patients receiving bisphosphonates and endocrine therapy.
Topics: Adult; Aged; Anastrozole; Bone Neoplasms; Breast Neoplasms; Diphosphonates; Female; Goserelin; Humans; Imidazoles; Letrozole; Magnetic Resonance Imaging; Middle Aged; Nitriles; Pamidronate; Pilot Projects; Prospective Studies; Tamoxifen; Triazoles; Zoledronic Acid | 2004 |
Characterization of stable human aromatase expressed in E. coli.
Topics: Amino Acid Sequence; Androstenedione; Arginine; Aromatase; Aromatase Inhibitors; Cell Membrane; Chaperonin 10; Chaperonin 60; Chloramphenicol; Cysteine; Electron Spin Resonance Spectroscopy; Enzyme Stability; Escherichia coli; Estradiol; Estrone; Fadrozole; Gene Expression; Humans; Letrozole; Molecular Sequence Data; Nitriles; Polymorphism, Genetic; Protein Structure, Secondary; Protein Synthesis Inhibitors; Recombinant Proteins; Solubility; Testosterone; Triazoles | 2004 |
Letrozole (Femara).
Topics: Administration, Oral; Aged; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Letrozole; Middle Aged; Nitriles; Oncology Nursing; Randomized Controlled Trials as Topic; Risk Assessment; Triazoles | 2004 |
Estrogen suppression induces papillary gingival overgrowth in pregnant baboons.
Topics: Animals; Aromatase Inhibitors; Biopsy; Cell Differentiation; Cell Division; Cesarean Section; Enzyme Inhibitors; Epithelial Cells; Estradiol; Estrogen Antagonists; Female; Gingival Hemorrhage; Gingival Hyperplasia; Gingival Overgrowth; Letrozole; Models, Animal; Nitriles; Papio; Pregnancy; Pregnancy Complications; Remission, Spontaneous; Time Factors; Triazoles | 2004 |
The aromatase inhibitor letrozole increases epiphyseal growth plate height and tibial length in peripubertal male mice.
Topics: Animals; Aromatase; Aromatase Inhibitors; Body Weight; Collagen; Collagen Type II; Collagen Type X; Growth Plate; Immunohistochemistry; Letrozole; Male; Mice; Mice, Inbred ICR; Nitriles; Receptor, IGF Type 1; Sexual Maturation; Tail; Tibia; Triazoles | 2004 |
Hippocampal synapses depend on hippocampal estrogen synthesis.
Topics: Animals; Animals, Newborn; Animals, Suckling; Aromatase Inhibitors; Dendritic Spines; Estradiol; Estrogens; Female; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Letrozole; Male; Microfilament Proteins; Nerve Endings; Nerve Tissue Proteins; Neuronal Plasticity; Nitriles; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Estrogen; Synapses; Synaptophysin; Triazoles | 2004 |
Clinical trials without ethical review under the spotlight.
Topics: Antineoplastic Agents; Clinical Trials as Topic; Developing Countries; Drug Industry; Drug Labeling; Ethics Committees, Research; Female; Fertility; Human Experimentation; Humans; India; Letrozole; Nitriles; Triazoles | 2004 |
An open randomised trial of second-line endocrine therapy in advanced breast cancer: comparison of the Aromatase inhibitors letrozole and anastrozole.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Randomized Controlled Trials as Topic; Triazoles | 2004 |
Effects of the antiestrogen tamoxifen and the aromatase inhibitor letrozole on serum hormones and bone characteristics in a preclinical tumor model for breast cancer.
Topics: Animals; Antineoplastic Agents; Aromatase; Body Composition; Breast Neoplasms; Cell Division; Cell Line, Tumor; Disease Models, Animal; Female; Humans; Letrozole; Mice; Mice, Nude; Mice, Transgenic; Nitriles; Ovariectomy; Tamoxifen; Transplantation, Heterologous; Triazoles | 2004 |
Effects of the steroidal aromatase inhibitor exemestane and the nonsteroidal aromatase inhibitor letrozole on bone and lipid metabolism in ovariectomized rats.
Topics: Amino Acids; Androstadienes; Animals; Aromatase Inhibitors; Bone and Bones; Cholesterol; Cholesterol, LDL; Female; Femur; Injections, Intramuscular; Letrozole; Lipid Metabolism; Lumbar Vertebrae; Nitriles; Osteocalcin; Ovariectomy; Rats; Rats, Sprague-Dawley; Steroids; Triazoles | 2004 |
Cellular mechanisms of sex determination in the red-eared slider turtle, Trachemys scripta.
Topics: Animals; Cell Movement; Embryo, Nonmammalian; Female; Letrozole; Male; Nitriles; Organogenesis; Sertoli Cells; Sex Determination Processes; Sex Differentiation; Testis; Triazoles; Turtles | 2004 |
Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3alpha-androstanediol and 17beta-estradiol.
Topics: Androstane-3,17-diol; Animals; Aromatase Inhibitors; Chromatography; Convulsants; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estradiol; Finasteride; Hippocampus; Letrozole; Male; Mass Spectrometry; Mice; Nitriles; Organ Culture Techniques; Patch-Clamp Techniques; Pentylenetetrazole; Rats; Receptors, GABA-A; Seizures; Testosterone; Triazoles | 2004 |
A method for making estimates of the benefit of the late use of letrozole in patients completing 5 years of tamoxifen.
Topics: Aged; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chemotherapy, Adjuvant; Cost-Benefit Analysis; Female; Humans; Letrozole; Lymph Nodes; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Prognosis; Receptors, Estrogen; Tamoxifen; Time Factors; Triazoles | 2004 |
Cost utility and budget impact of third-generation aromatase inhibitors for advanced breast cancer: a literature-based model analysis of costs in the Italian National Health Service.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Budgets; Cost-Benefit Analysis; Decision Support Techniques; Drug Costs; Female; Humans; Italy; Letrozole; Markov Chains; Megestrol; Models, Economic; National Health Programs; Nitriles; Postmenopause; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles | 2004 |
Regulation of placental vascular endothelial growth/permeability factor expression and angiogenesis by estrogen during early baboon pregnancy.
Topics: Animals; Estradiol; Female; Fetal Weight; Gene Expression Regulation, Developmental; Letrozole; Neovascularization, Physiologic; Nitriles; Papio; Placenta; Pregnancy; Pregnancy, Animal; RNA, Messenger; Triazoles; Vascular Endothelial Growth Factor A | 2004 |
Effects of exemestane and tamoxifen in a postmenopausal breast cancer model.
Topics: Androstadienes; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Disease Progression; Dose-Response Relationship, Drug; Female; Humans; Letrozole; Mammary Neoplasms, Animal; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Random Allocation; Tamoxifen; Time Factors; Triazoles | 2004 |
The responsiveness of a tumour to any kind of therapy is reflected by the objective response rate.
Topics: Anastrozole; Antineoplastic Agents; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Triazoles | 2004 |
Low-grade endometrial stromal sarcoma treated with the aromatase inhibitor letrozole.
Topics: Aged; Antineoplastic Agents; Aromatase Inhibitors; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Sarcoma, Endometrial Stromal; Triazoles | 2004 |
New drugs reduce risk of death from breast cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Triazoles | 2004 |
Estrogen elicits cortical zone-specific effects on development of the primate fetal adrenal gland.
Topics: Adrenal Cortex; Animals; Dehydroepiandrosterone Sulfate; Estradiol; Estrogens; Estrone; Female; Fetal Development; Letrozole; Nitriles; Organ Size; Papio; Pituitary Gland; Pro-Opiomelanocortin; RNA, Messenger; Triazoles | 2005 |
Letrozole sensitizes breast cancer cells to ionizing radiation.
Topics: Antineoplastic Agents; Aromatase; Breast Neoplasms; Cell Cycle; Cell Survival; Female; Flow Cytometry; Humans; Letrozole; Nitriles; Radiation-Sensitizing Agents; Radiotherapy, Adjuvant; Transfection; Triazoles | 2005 |
Hormonal profile and endometrial morphology in letrozole-controlled ovarian hyperstimulation in ovulatory infertile patients.
Topics: Adult; Aromatase Inhibitors; Endometrium; Estradiol; Female; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Progesterone; Prospective Studies; Triazoles | 2005 |
Letrozole significantly improves growth potential in a pubertal boy with growth hormone deficiency.
Topics: Adolescent; Aromatase Inhibitors; Biomarkers; Bone Density; Drug Therapy, Combination; Growth Disorders; Human Growth Hormone; Humans; Insulin-Like Growth Factor I; Letrozole; Lipids; Male; Nitriles; Testosterone; Triazoles | 2005 |
Pregnancy outcome after the use of an aromatase inhibitor for ovarian stimulation.
Topics: Abortion, Spontaneous; Aromatase Inhibitors; Cohort Studies; Female; Humans; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Outcome; Pregnancy Rate; Pregnancy, Multiple; Triazoles | 2005 |
Aromatase expression in ovarian epithelial cancers.
Topics: Androstadienes; Aromatase; Aromatase Inhibitors; Cell Proliferation; Cysts; Epithelial Cells; Estrogen Receptor alpha; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Lasers; Letrozole; Microdissection; Middle Aged; Neoplasms, Glandular and Epithelial; Nitriles; Ovarian Neoplasms; Ovary; Polymerase Chain Reaction; RNA, Messenger; Triazoles; Tumor Cells, Cultured | 2005 |
Endogenous aromatization of testosterone results in growth stimulation of the human MCF-7 breast cancer cell line.
Topics: Androgens; Androstenedione; Aromatase; Aromatase Inhibitors; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Culture Media; Dose-Response Relationship, Drug; Estrogen Antagonists; Estrogens; Estrone; Female; Humans; Letrozole; Nitriles; Receptors, Estrogen; Testosterone; Triazoles; Tumor Cells, Cultured | 2005 |
Letrozole better than tamoxifen in postmenopausal women.
Topics: Antineoplastic Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Nitriles; Postmenopause; Tamoxifen; Triazoles | 2005 |
[Efforts in the individualization of the adjuvant systemic therapy in breast cancer--ASCO, 2004].
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Gene Expression Regulation, Neoplastic; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Patient Care Planning; Patient Satisfaction; Patient Selection; Predictive Value of Tests; Quality of Life; Receptor, ErbB-2; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; Tamoxifen; Triazoles | 2004 |
Stimulating effects of androgen on proliferation of cultured ovarian germ cells through androgenic and estrogenic actions in embryonic chickens.
Topics: Animals; Chick Embryo; Coculture Techniques; Female; Flutamide; Hormone Antagonists; Immunohistochemistry; Letrozole; Microscopy, Phase-Contrast; Nitriles; Ovary; Ovum; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-kit; Tamoxifen; Testosterone; Triazoles | 2005 |
Letrozole-, anastrozole-, and tamoxifen-responsive genes in MCF-7aro cells: a microarray approach.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Cell Division; Cell Line, Tumor; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Letrozole; Nitriles; Oligonucleotide Array Sequence Analysis; Tamoxifen; Triazoles; Up-Regulation | 2005 |
Serum soluble epidermal growth factor receptor concentrations decrease in postmenopausal metastatic breast cancer patients treated with letrozole.
Topics: Antineoplastic Agents; Breast Neoplasms; Case-Control Studies; ErbB Receptors; Female; Humans; Letrozole; Nitriles; Postmenopause; Solubility; Triazoles | 2005 |
Oxytocin mediates the estrogen-dependent contractile activity of endothelin-1 in human and rabbit epididymis.
Topics: Animals; Endothelin-1; Epididymis; Estradiol; Hypogonadism; Letrozole; Male; Muscle Contraction; Nitriles; Oxytocin; Rabbits; Rats; Triazoles; Triptorelin Pamoate | 2005 |
A letrozole-based dual aromatase-sulphatase inhibitor with in vivo activity.
Topics: Aromatase Inhibitors; Enzyme Inhibitors; Indicators and Reagents; Letrozole; Nitriles; Sulfatases; Triazoles | 2005 |
[Comparison of letrozole and exemestane used in non-adjuvant therapy of endometrial carcinoma].
Topics: Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Endometrial Neoplasms; Female; Follicle Stimulating Hormone; Humans; Letrozole; Luteinizing Hormone; Nitriles; Receptors, Estrogen; Receptors, Progesterone; Triazoles | 2005 |
Further evidence on the safety and success of ovarian stimulation with letrozole and tamoxifen in breast cancer patients undergoing in vitro fertilization to cryopreserve their embryos for fertility preservation.
Topics: Aromatase Inhibitors; Breast Neoplasms; Cryopreservation; Embryo, Mammalian; Estrogen Antagonists; Female; Fertility; Fertilization in Vitro; Humans; Letrozole; Nitriles; Oocytes; Ovulation Induction; Tamoxifen; Triazoles | 2005 |
Diabetes insipidus caused by isolated intracranial metatstases in patient with breast cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Deamino Arginine Vasopressin; Diabetes Insipidus; Fatal Outcome; Female; Humans; Letrozole; Magnetic Resonance Imaging; Meningeal Neoplasms; Middle Aged; Nitriles; Pituitary Neoplasms; Renal Agents; Triazoles | 2005 |
Serum HER-2/neu conversion to positive at the time of disease progression in patients with breast carcinoma on hormone therapy.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Carcinoma; Disease Progression; Estrogen Antagonists; Female; Humans; Letrozole; Nitriles; Prognosis; Receptor, ErbB-2; Survival Analysis; Tamoxifen; Triazoles | 2005 |
Activation of mitogen-activated protein kinase in xenografts and cells during prolonged treatment with aromatase inhibitor letrozole.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Drug Administration Schedule; Enzyme Activation; Estrogen Receptor alpha; Female; Humans; Letrozole; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Nude; Mitogen-Activated Protein Kinases; Nitriles; Tamoxifen; Triazoles; Xenograft Model Antitumor Assays | 2005 |
Additive antitumor effect of aromatase inhibitor letrozole and antiestrogen fulvestrant in a postmenopausal breast cancer model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Estradiol; Estrogen Receptor Modulators; Female; Fulvestrant; Humans; Letrozole; Mice; Mice, Inbred BALB C; Mice, Nude; Nitriles; Postmenopause; Tamoxifen; Triazoles; Xenograft Model Antitumor Assays | 2005 |
Hormonal treatment with aromatase inhibitors for patients with endometrial stromal sarcoma.
Topics: Aged; Aromatase Inhibitors; Endometrial Neoplasms; Female; Humans; Letrozole; Nitriles; Sarcoma, Endometrial Stromal; Triazoles | 2005 |
Model systems: mechanisms involved in the loss of sensitivity to letrozole.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Drug Resistance, Neoplasm; Estradiol; Female; Fulvestrant; GRB2 Adaptor Protein; Humans; Letrozole; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Models, Biological; Nitriles; Receptors, Estrogen; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tamoxifen; Triazoles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2005 |
Aromatase inhibitors: cellular and molecular effects.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Cell Proliferation; Drug Resistance, Neoplasm; Female; Gene Expression; Humans; Ki-67 Antigen; Letrozole; Neoadjuvant Therapy; Nitriles; Oligonucleotide Array Sequence Analysis; Receptors, Progesterone; Tamoxifen; Triazoles | 2005 |
The aromatase inhibitor letrozole increases the concentration of intraovarian androgens and improves in vitro fertilization outcome in low responder patients: a pilot study.
Topics: Adult; Androgens; Aromatase Inhibitors; Chi-Square Distribution; Female; Fertilization in Vitro; Humans; Letrozole; Nitriles; Ovary; Ovulation Induction; Pilot Projects; Pregnancy; Prospective Studies; Triazoles | 2005 |
Maintenance hormone therapy with letrozole after first-line chemotherapy for advanced breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Disease Progression; Female; Humans; Letrozole; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Quality of Life; Receptors, Estrogen; Receptors, Progesterone; Time Factors; Treatment Outcome; Triazoles | 2005 |
Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma; Cell Proliferation; Cell Survival; Drug Interactions; Estrogens; Everolimus; Female; Humans; Immunosuppressive Agents; Letrozole; Nitriles; Protein Kinases; Receptors, Estrogen; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Triazoles; Tumor Cells, Cultured | 2005 |
Letrozole in the extended adjuvant treatment of postmenopausal women with history of early-stage breast cancer who have completed 5 years of adjuvant tamoxifen.
Topics: Aged; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Bone Density; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Dizziness; Double-Blind Method; Drug Approval; Female; Follow-Up Studies; Headache; Humans; Letrozole; Middle Aged; Multicenter Studies as Topic; Neoplasm Staging; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Skin Diseases; Tamoxifen; Time Factors; Treatment Outcome; Triazoles; United States; United States Food and Drug Administration | 2005 |
Breast cancer's 'new era'.
Topics: Antineoplastic Agents; Breast Neoplasms; Double-Blind Method; Female; Humans; Letrozole; Nitriles; Secondary Prevention; Treatment Outcome; Triazoles; United States | 2003 |
Estrogen synthesis in the central nucleus of the amygdala following middle cerebral artery occlusion: role in modulating neurotransmission.
Topics: Amygdala; Animals; Aromatase Inhibitors; Autonomic Nervous System; Blood Pressure; Brain Chemistry; Estradiol; Estrogen Antagonists; Estrogens; Excitatory Amino Acid Antagonists; Fulvestrant; Heart Rate; Infarction, Middle Cerebral Artery; Injections, Intraventricular; Letrozole; Male; Microdialysis; Nitriles; Piperazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Testosterone; Triazoles | 2005 |
Letrozole for brain and scalp metastases from breast cancer--a case report.
Topics: Aromatase Inhibitors; Brain Neoplasms; Breast Neoplasms; Female; Head and Neck Neoplasms; Humans; Letrozole; Middle Aged; Nitriles; Scalp; Skin Neoplasms; Tomography, X-Ray Computed; Triazoles | 2006 |
[Aromatase inhibitors in the treatment of breast cancer: current status and some problems].
Topics: Adult; Anastrozole; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Middle Aged; Nitriles; Triazoles | 2005 |
Options for preservation of fertility in women.
Topics: Algorithms; Antineoplastic Agents; Breast Neoplasms; Cryopreservation; Drug Therapy, Combination; Embryo, Mammalian; Female; Fertility; Gonadotropins; Humans; Letrozole; Neoplasms; Nitriles; Ovary; Tamoxifen; Transplantation, Heterotopic; Triazoles | 2005 |
Antiestrogens upregulate estrogen receptor beta expression and inhibit adrenocortical H295R cell proliferation.
Topics: Adrenal Cortex; Adrenal Cortex Neoplasms; Androgens; Apoptosis; Aromatase; Aromatase Inhibitors; Autocrine Communication; Caspases; Cell Line, Tumor; Cell Proliferation; Colforsin; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogen Receptor Modulators; Fas Ligand Protein; fas Receptor; Humans; Letrozole; Membrane Glycoproteins; Nitriles; Promoter Regions, Genetic; RNA, Messenger; Triazoles; Tumor Necrosis Factors | 2005 |
Comparative bioavailability study of two preparations of letrozole in healthy subjects.
Topics: Adolescent; Adult; Antineoplastic Agents; Area Under Curve; Biological Availability; Calibration; Chemistry, Pharmaceutical; Half-Life; Humans; Letrozole; Male; Nitriles; Reproducibility of Results; Triazoles | 2005 |
Growth inhibition of estrogen receptor-positive and aromatase-positive human breast cancer cells in monolayer and spheroid cultures by letrozole, anastrozole, and tamoxifen.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Estrogen Antagonists; Humans; Inhibitory Concentration 50; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Receptors, Estrogen; Tamoxifen; Time Factors; Triazoles | 2005 |
Successful treatment of an aggressive recurrent post-menopausal endometriosis with an aromatase inhibitor.
Topics: Aromatase Inhibitors; Colon, Sigmoid; Endometriosis; Female; Humans; Hysterectomy; Letrozole; Middle Aged; Nitriles; Postmenopause; Recurrence; Sciatica; Time Factors; Treatment Outcome; Triazoles | 2005 |
Identification of the aromatase inhibitor letrozole in urine by gas chromatography/mass spectrometry.
Topics: Aromatase Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Humans; Letrozole; Molecular Structure; Nitriles; Reproducibility of Results; Sensitivity and Specificity; Triazoles | 2005 |
Neurosteroid synthesis in the hippocampus: role in synaptic plasticity.
Topics: Animals; Animals, Newborn; Aromatase Inhibitors; Cell Count; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Estradiol; GAP-43 Protein; Gene Expression Regulation; Hippocampus; Immunohistochemistry; In Situ Hybridization; In Vitro Techniques; Letrozole; Microfilament Proteins; Microscopy, Immunoelectron; Nerve Tissue Proteins; Neuronal Plasticity; Neurons; Nitriles; Presynaptic Terminals; Rats; Rats, Wistar; RNA, Messenger; Synapses; Synaptophysin; Triazoles | 2005 |
Harm or benefit of hormonal treatment in metastatic low-grade endometrial stromal sarcoma: single center experience with 10 cases and review of the literature.
Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Endometrial Stromal Tumors; Estrogen Replacement Therapy; Female; Humans; Letrozole; Medroxyprogesterone Acetate; Middle Aged; Nitriles; Pelvic Neoplasms; Peritoneal Neoplasms; Retrospective Studies; Tamoxifen; Triazoles; Uterine Neoplasms | 2006 |
Aromatase inhibitors--a triumph of translational oncology.
Topics: Animals; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease Models, Animal; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles | 2005 |
Sequential treatment with exemestane and non-steroidal aromatase inhibitors in advanced breast cancer.
Topics: Aged; Aged, 80 and over; Anastrozole; Androstadienes; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Confidence Intervals; Disease Progression; Drug Administration Schedule; Female; Humans; Letrozole; Lymphatic Metastasis; Middle Aged; Neoplasm Staging; Nitriles; Postmenopause; Treatment Outcome; Triazoles | 2005 |
Latest studies hint at survival advantage with aromatase inhibitors in early breast cancer.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Europe; Female; Humans; Letrozole; Meta-Analysis as Topic; Neoplasm Recurrence, Local; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Survival Analysis; Survival Rate; Treatment Outcome; Triazoles | 2006 |
Oral ovulation induction agents combined with low-dose gonadotropin injections and intrauterine insemination: cost- and clinical effectiveness.
Topics: Administration, Oral; Adult; Analysis of Variance; Clomiphene; Cost-Benefit Analysis; Female; Fertility Agents, Female; Humans; Infertility; Injections; Insemination, Artificial; Letrozole; Menotropins; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Retrospective Studies; Tamoxifen; Triazoles | 2005 |
Toxic epidermal necrolysis in patient with breast cancer receiving letrozole.
Topics: Antineoplastic Agents; Breast Neoplasms; Carcinoma, Ductal, Breast; Fatal Outcome; Female; Humans; Letrozole; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Nitriles; Stevens-Johnson Syndrome; Triazoles | 2006 |
Paternal responsiveness in biparental dwarf hamsters (Phodopus campbelli) does not require estradiol.
Topics: Aggression; Animals; Aromatase; Aromatase Inhibitors; Cricetinae; Drug Implants; Estradiol; Female; Letrozole; Male; Nitriles; Paternal Behavior; Phodopus; Statistics, Nonparametric; Testosterone; Triazoles | 2006 |
Locally produced estrogen promotes fetal rat metatarsal bone growth; an effect mediated through increased chondrocyte proliferation and decreased apoptosis.
Topics: Animals; Apoptosis; Aromatase Inhibitors; Cell Division; Cell Line; Chondrocytes; Estradiol; Estrogen Antagonists; Estrogens; Fulvestrant; Humans; Immunohistochemistry; Insulin-Like Growth Factor I; Letrozole; Metatarsal Bones; Nitriles; Rats; Triazoles | 2006 |
ErbB receptor signaling and therapeutic resistance to aromatase inhibitors.
Topics: Acetyltransferases; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Carrier Proteins; Cell Line, Tumor; Corticosterone; Drug Resistance, Neoplasm; Female; Histone Acetyltransferases; Humans; Letrozole; Nitriles; Nuclear Receptor Coactivator 3; Oncogene Proteins; Promoter Regions, Genetic; Receptor, ErbB-2; Receptors, Estrogen; Signal Transduction; Trans-Activators; Transcriptional Activation; Triazoles | 2006 |
Effectiveness of letrozole in the breast cancer treatment continuum.
Topics: Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Treatment Outcome; Triazoles | 2006 |
Inhibition of hippocampal estrogen synthesis causes region-specific downregulation of synaptic protein expression in hippocampal neurons.
Topics: Animals; Aromatase; Aromatase Inhibitors; Cells, Cultured; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Estrogens; Hippocampus; Image Processing, Computer-Assisted; Immunohistochemistry; Letrozole; Microfilament Proteins; Nerve Tissue Proteins; Neurons; Nitriles; Phosphoproteins; Pyramidal Cells; Rats; Rats, Wistar; Synapses; Synaptophysin; Triazoles | 2006 |
Changing the gold standard in adjuvant therapy for breast cancer:from tamoxifen to aromatase inhibition.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles | 2005 |
The effects of testosterone and oestrogen on gonadectomised and intact male rat anterior pituitary mitotic and apoptotic activity.
Topics: Animals; Apoptosis; Aromatase Inhibitors; Dihydrotestosterone; Dose-Response Relationship, Drug; Estradiol; Gonadal Steroid Hormones; Image Processing, Computer-Assisted; Injections; Letrozole; Male; Mitosis; Nitriles; Orchiectomy; Pituitary Gland, Anterior; Rats; Rats, Wistar; Staining and Labeling; Testosterone; Time Factors; Triazoles | 2006 |
Letrozole in postmenopausal hormone-responsive early-stage breast cancer : a viewpoint by Laura B. Michaud.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Cardiovascular Diseases; Chemotherapy, Adjuvant; Clinical Trials as Topic; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Osteoporosis, Postmenopausal; Postmenopause; Triazoles | 2006 |
Letrozole in postmenopausal hormone-responsive early-stage breast cancer: a viewpoint by Gerald M. Higa.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Disease-Free Survival; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Osteoporosis, Postmenopausal; Postmenopause; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles | 2006 |
Resumption of menses with initiation of letrozole after five years of amenorrhea on tamoxifen: caution needed when using tamoxifen followed by aromatase inhibitors.
Topics: Adult; Amenorrhea; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Menstruation; Neoplasm Recurrence, Local; Nitriles; Postmenopause; Premenopause; Tamoxifen; Triazoles | 2006 |
Does survival increase in metastatic breast cancer with recently available anticancer drugs?
Topics: Aged; Anastrozole; Androstadienes; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Female; Humans; Letrozole; Middle Aged; Neoplasm Metastasis; Nitriles; Retrospective Studies; Survival Analysis; Tamoxifen; Triazoles | 2006 |
Proliferation and apoptosis of hippocampal granule cells require local oestrogen synthesis.
Topics: Animals; Animals, Newborn; Apoptosis; Aromatase Inhibitors; Cell Proliferation; Cells, Cultured; Culture Media, Serum-Free; Dentate Gyrus; Dose-Response Relationship, Drug; Down-Regulation; Estrogens; Letrozole; Necrosis; Neuronal Plasticity; Neurons; Nitriles; Paracrine Communication; Phosphoproteins; Rats; Rats, Wistar; RNA, Small Interfering; Triazoles | 2006 |
Letrozole induction of ovulation in women with clomiphene citrate-resistant polycystic ovary syndrome may not depend on the period of infertility, the body mass index, or the luteinizing hormone/follicle-stimulating hormone ratio.
Topics: Adult; Aromatase Inhibitors; Body Mass Index; Clomiphene; Drug Resistance; Female; Fertility Agents, Female; Follicle Stimulating Hormone; Humans; Infertility, Female; Letrozole; Luteinizing Hormone; Nitriles; Ovulation; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Retreatment; Triazoles | 2006 |
Letrozole or tamoxifen in early breast cancer.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Data Interpretation, Statistical; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles | 2006 |
Letrozole or tamoxifen in early breast cancer.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cardiovascular Diseases; Chemotherapy, Adjuvant; Humans; Letrozole; Lymphatic Metastasis; Nitriles; Secondary Prevention; Tamoxifen; Triazoles | 2006 |
Letrozole or tamoxifen in early breast cancer.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cardiovascular Diseases; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles | 2006 |
Serum endostatin and bFGF as predictive factors in advanced breast cancer patients treated with letrozole.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Breast Neoplasms, Male; Disease Progression; Endostatins; Female; Fibroblast Growth Factor 2; Humans; Letrozole; Male; Middle Aged; Nitriles; Predictive Value of Tests; Prospective Studies; Triazoles | 2006 |
Congenital malformations among 911 newborns conceived after infertility treatment with letrozole or clomiphene citrate.
Topics: Adult; Aromatase Inhibitors; Canada; Clomiphene; Comorbidity; Congenital Abnormalities; Female; Fertility Agents, Female; Humans; Incidence; Infant, Newborn; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Outcome; Retrospective Studies; Risk Assessment; Risk Factors; Treatment Outcome; Triazoles | 2006 |
Lack of aromatisation of the 3-keto-4-ene metabolite of tibolone to an estrogenic derivative.
Topics: Aromatase; Aromatase Inhibitors; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Estradiol; Estrogen Replacement Therapy; Estrogens; Ethinyl Estradiol; Letrozole; Nitriles; Norethindrone; Norpregnenes; Triazoles; Tumor Cells, Cultured | 2006 |
Adjuvant aromatase inhibitors for early breast cancer after chemotherapy-induced amenorrhoea: caution and suggested guidelines.
Topics: Adult; Amenorrhea; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Estrogen Receptor Modulators; Female; Follicle Stimulating Hormone; Humans; Letrozole; Luteinizing Hormone; Middle Aged; Neoplasm Staging; Nitriles; Ovariectomy; Practice Guidelines as Topic; Tamoxifen; Triazoles | 2006 |
Estrogen-independent proliferation is present in estrogen-receptor HER2-positive primary breast cancer after neoadjuvant letrozole.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Cell Proliferation; Female; Gene Amplification; Genes, erbB-1; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Letrozole; Middle Aged; Neoadjuvant Therapy; Nitriles; Receptor, ErbB-2; Receptors, Estrogen; Treatment Outcome; Triazoles | 2006 |
Pharmacoeconomic analysis of adjuvant therapy with exemestane, anastrozole, letrozole or tamoxifen in postmenopausal women with operable and estrogen receptor-positive breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Cohort Studies; Computer Simulation; Cost-Benefit Analysis; Estrogen Antagonists; Estrogens; Fees, Pharmaceutical; Female; Follow-Up Studies; Humans; Letrozole; Markov Chains; Middle Aged; Models, Theoretical; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Receptors, Estrogen; Tamoxifen; Triazoles | 2006 |
Primary hormone treatment in postmenopausal women with breast cancer.
Topics: Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Carcinoma, Ductal, Breast; Contraindications; Estrogens; Female; Humans; Letrozole; Mastectomy; Neoadjuvant Therapy; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Radiography; Receptors, Estrogen; Triazoles | 2006 |
Estrogen receptors: role in breast cancer.
Topics: Anastrozole; Aromatase Inhibitors; Breast Neoplasms; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Female; Gene Expression Regulation, Neoplastic; Gonadotropin-Releasing Hormone; Hormone Replacement Therapy; Humans; Letrozole; Models, Biological; Nitriles; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles | 2006 |
In men, peripheral estradiol levels directly reflect the action of estrogens at the hypothalamo-pituitary level to inhibit gonadotropin secretion.
Topics: Adult; Aromatase Inhibitors; Estradiol; Follicle Stimulating Hormone; Gonadotropins; Humans; Hypothalamo-Hypophyseal System; Letrozole; Linear Models; Luteinizing Hormone; Male; Nitriles; Pituitary-Adrenal System; Sex Hormone-Binding Globulin; Testosterone; Triazoles | 2006 |
Management of choroidal metastases from breast carcinomas using aromatase inhibitors.
Topics: Aged; Aged, 80 and over; Anastrozole; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Choroid Neoplasms; Combined Modality Therapy; Female; Humans; Letrozole; Mastectomy, Radical; Mastectomy, Segmental; Mastectomy, Simple; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Treatment Outcome; Triazoles | 2006 |
Cost-effectiveness of letrozole in the extended adjuvant treatment of women with early breast cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Cost-Benefit Analysis; Female; Humans; Letrozole; Middle Aged; Nitriles; Quality-Adjusted Life Years; Tamoxifen; Treatment Outcome; Triazoles | 2007 |
Cost-effectiveness of extended adjuvant letrozole therapy after 5 years of adjuvant tamoxifen therapy in postmenopausal women with early-stage breast cancer.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Cohort Studies; Cost-Benefit Analysis; Decision Support Techniques; Disease Progression; Female; Humans; Letrozole; Markov Chains; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasm Staging; Nitriles; Postmenopause; Quality-Adjusted Life Years; Tamoxifen; Time Factors; Triazoles; United States | 2006 |
A single intravenous administration of zoledronic acid prevents the bone loss and mechanical compromise induced by aromatase inhibition in rats.
Topics: Animals; Aromatase Inhibitors; Biomechanical Phenomena; Body Weight; Bone and Bones; Bone Density; Bone Density Conservation Agents; Diphosphonates; Estrogens; Female; Imidazoles; Injections, Intravenous; Letrozole; Nitriles; Organ Size; Osteocalcin; Osteoporosis; Ovariectomy; RANK Ligand; Rats; Rats, Wistar; Triazoles; Uterus; Zoledronic Acid | 2006 |
Leuprolide acetate plus aromatase inhibition for male breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Bone Neoplasms; Breast Neoplasms, Male; Carcinoma, Ductal, Breast; Chemotherapy, Adjuvant; Humans; Letrozole; Leuprolide; Lung Neoplasms; Lymphatic Metastasis; Male; Mastectomy, Modified Radical; Middle Aged; Nitriles; Receptors, Estrogen; Receptors, Progesterone; Treatment Outcome; Triazoles | 2006 |
Letrozole reduces estrogen and gonadotropin exposure in women with breast cancer undergoing ovarian stimulation before chemotherapy.
Topics: Adult; Breast Neoplasms; Chorionic Gonadotropin; Cost-Benefit Analysis; Cryopreservation; Embryo Transfer; Estradiol; Female; Fertilization in Vitro; Follicle Stimulating Hormone; Humans; Letrozole; Nitriles; Oocytes; Ovulation Induction; Retrospective Studies; Triazoles | 2006 |
Role of androgens on MCF-7 breast cancer cell growth and on the inhibitory effect of letrozole.
Topics: Androgen Receptor Antagonists; Androgens; Androstenedione; Aromatase; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Dihydrotestosterone; Estradiol; Estrogen Receptor alpha; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Proto-Oncogene Proteins c-bcl-2; Receptors, Androgen; RNA, Small Interfering; Transfection; Triazoles | 2006 |
Re: Randomized trial of letrozole following tamoxifen as extended adjuvant therapy in receptor-positive breast cancer: updated findings from NCIC CTG MA.17.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Estrogen Receptor Modulators; Female; Humans; Letrozole; Nitriles; Patient Selection; Progesterone; Randomized Controlled Trials as Topic; Receptors, Estrogen; Tamoxifen; Treatment Outcome; Triazoles | 2006 |
The effect of tamoxifen on the pharmacokinetics of letrozole in female rats.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Dose-Response Relationship, Drug; Drug Interactions; Estrogen Antagonists; Female; Half-Life; Letrozole; Molecular Structure; Nitriles; Rats; Rats, Sprague-Dawley; Tamoxifen; Triazoles | 2006 |
Quality of life in a randomized control trial? Comments concerning MA 17.
Topics: Antineoplastic Agents, Hormonal; Bias; Breast Neoplasms; Chemotherapy, Adjuvant; Confounding Factors, Epidemiologic; Data Interpretation, Statistical; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Patient Compliance; Patient Dropouts; Postmenopause; Quality of Life; Randomized Controlled Trials as Topic; Research Design; Surveys and Questionnaires; Survival Analysis; Triazoles | 2006 |
Fertility preservation strategies for breast cancer patients.
Topics: Antineoplastic Agents; Breast Neoplasms; Evidence-Based Medicine; Female; Fertility; Humans; Letrozole; Nitriles; Triazoles | 2006 |
Microscopic characterization of follicular structures in letrozole-induced polycystic ovarian syndrome in the rat.
Topics: Animals; Cadherins; Desmin; Female; Hormones; Immunohistochemistry; Keratins; Letrozole; Nitriles; Ovarian Follicle; Polycystic Ovary Syndrome; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; Triazoles; Vimentin | 2006 |
Neuroprotection by estradiol: a role of aromatase against spine synapse loss after blockade of GABA(A) receptors.
Topics: Animals; Aromatase; Cells, Cultured; Dendritic Spines; Down-Regulation; Enzyme Inhibitors; Epilepsy; Estradiol; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Letrozole; Nerve Degeneration; Neural Inhibition; Neuroprotective Agents; Nitriles; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, GABA-A; Synaptic Transmission; Triazoles | 2007 |
Oestrogen synthesis in the hippocampus: role in axon outgrowth.
Topics: Animals; Aromatase; Aromatase Inhibitors; Cells, Cultured; Down-Regulation; Estradiol; GAP-43 Protein; Hippocampus; Letrozole; Neurites; Neuronal Plasticity; Nitriles; Phosphoproteins; Rats; RNA, Small Interfering; Tissue Distribution; Triazoles | 2006 |
Late risk of relapse and mortality among postmenopausal women with estrogen responsive early breast cancer after 5 years of tamoxifen.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; British Columbia; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Prognosis; Risk Factors; Survival Rate; Tamoxifen; Triazoles | 2007 |
Aromatase inhibitors and bipolar mood disorder: a case report.
Topics: Aggression; Anastrozole; Aromatase Inhibitors; Bipolar Disorder; Breast Neoplasms; Carcinoma, Lobular; Chemotherapy, Adjuvant; Combined Modality Therapy; Depressive Disorder, Major; Female; Humans; Irritable Mood; Letrozole; Middle Aged; Nitriles; Substance Withdrawal Syndrome; Triazoles | 2006 |
Biotransformation of letrozole in rat liver microsomes: effects of gender and tamoxifen.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Biotransformation; Calibration; Chromatography, High Pressure Liquid; Drug Interactions; Female; In Vitro Techniques; Letrozole; Male; Mass Spectrometry; Microsomes, Liver; Nitriles; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sex Characteristics; Spectrophotometry, Ultraviolet; Tamoxifen; Triazoles | 2007 |
Debilitating musculoskeletal pain and stiffness with letrozole and exemestane: associated tenosynovial changes on magnetic resonance imaging.
Topics: Aged; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Carpal Tunnel Syndrome; Female; Humans; Letrozole; Magnetic Resonance Imaging; Middle Aged; Musculoskeletal Diseases; Nitriles; Pain; Severity of Illness Index; Triazoles; Ultrasonography; Wrist Joint | 2007 |
The effects of atamestane and toremifene alone and in combination compared with letrozole on bone, serum lipids and the uterus in an ovariectomized rat model.
Topics: Androstenedione; Animals; Antineoplastic Combined Chemotherapy Protocols; Disease Models, Animal; Female; Humans; Letrozole; Lipids; Models, Chemical; Nitriles; Organ Size; Ovariectomy; Rats; Rats, Sprague-Dawley; Toremifene; Triazoles; Uterus | 2007 |
Mammalian target of rapamycin inhibitors in combination with letrozole in breast cancer.
Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Drug Resistance, Neoplasm; Everolimus; Female; Humans; Letrozole; Nitriles; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Kinases; Sirolimus; TOR Serine-Threonine Kinases; Treatment Outcome; Triazoles | 2006 |
Clinically occult cutaneous metastases.
Topics: Aged; Aged, 80 and over; Anastrozole; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Breast Neoplasms; Capecitabine; Carcinoma; Carcinoma, Basal Cell; Carcinoma, Lobular; Carcinoma, Signet Ring Cell; Deoxycytidine; Estradiol; Facial Neoplasms; Female; Fluorouracil; Fulvestrant; Humans; Incidental Findings; Letrozole; Mastectomy, Radical; Megestrol Acetate; Melanoma; Neoplasms, Second Primary; Neoplastic Cells, Circulating; Nitriles; Selective Estrogen Receptor Modulators; Skin Neoplasms; Tamoxifen; Triazoles; Wound Healing | 2006 |
Aromatase and breast cancer.
Topics: Animals; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Drug Resistance, Neoplasm; Drug Therapy, Combination; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Humans; Letrozole; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Nude; Nitriles; Ovariectomy; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptor, ErbB-2; Receptors, Estrogen; Signal Transduction; Tamoxifen; Triazoles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2006 |
Effects of novel retinoic acid metabolism blocking agent (VN/14-1) on letrozole-insensitive breast cancer cells.
Topics: Animals; Apoptosis Regulatory Proteins; Aromatase; Aromatase Inhibitors; Blotting, Western; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Histone Acetyltransferases; Hormones; Humans; Imidazoles; Letrozole; Mice; Mice, Nude; Microsomes; Mitogen-Activated Protein Kinases; Nitriles; Nuclear Receptor Coactivator 3; Ovariectomy; Placenta; Pregnancy; Trans-Activators; Tretinoin; Triazoles; Xenograft Model Antitumor Assays | 2006 |
Ontogeny of androgen and estrogen receptor expression in porcine testis: effect of reducing testicular estrogen synthesis.
Topics: Aging; Animals; Aromatase Inhibitors; Blotting, Western; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Immunohistochemistry; Letrozole; Male; Nitriles; Receptors, Androgen; Sertoli Cells; Swine; Testis; Triazoles | 2007 |
Fas ligand expression in TM4 Sertoli cells is enhanced by estradiol "in situ" production.
Topics: Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Bucladesine; Chromatin Immunoprecipitation; DNA; Electrophoretic Mobility Shift Assay; Estradiol; Estrogen Receptor alpha; Fas Ligand Protein; Follicle Stimulating Hormone; Genes, Reporter; HeLa Cells; Humans; Immune Tolerance; Letrozole; Luciferases; Male; Mice; Mice, Inbred BALB C; Mutation; Nitriles; Promoter Regions, Genetic; RNA, Messenger; Sertoli Cells; Sp1 Transcription Factor; Transcription, Genetic; Transfection; Triazoles; Up-Regulation | 2007 |
Aromatase inhibitors in ovarian stimulation.
Topics: Aromatase Inhibitors; Female; Humans; Infant, Newborn; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Triazoles | 2006 |
[Correlation of hormone-metabolic status in breast cancer and effectiveness of adjuvant hormone therapy].
Topics: Aged; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; C-Peptide; Chemotherapy, Adjuvant; Estradiol; Female; Humans; Insulin; Insulin Resistance; Letrozole; Middle Aged; Nitriles; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Time Factors; Triazoles | 2006 |
Placental expression and molecular characterization of aromatase cytochrome P450 in the spotted hyena (Crocuta crocuta).
Topics: Animals; Aromatase; Aromatase Inhibitors; Clitoris; Female; Humans; Hyaenidae; Letrozole; Nitriles; Phylogeny; Placenta; Pregnancy; Triazoles; Virilism | 2007 |
Cost-utility of adjuvant hormone therapies with aromatase inhibitors in post-menopausal women with breast cancer: upfront anastrozole, sequential tamoxifen-exemestane and extended tamoxifen-letrozole.
Topics: Aged; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Belgium; Breast Neoplasms; Canada; Chemotherapy, Adjuvant; Cost-Benefit Analysis; Drug Costs; Female; Humans; Letrozole; Markov Chains; Middle Aged; Nitriles; Postmenopause; Proportional Hazards Models; Quality-Adjusted Life Years; Tamoxifen; Triazoles | 2007 |
Beta2-agonists and paresthesias in multiple sclerosis.
Topics: Adrenergic beta-Agonists; Albuterol; Amantadine; Analgesics, Non-Narcotic; Androstadienes; Aromatase Inhibitors; Asthma; Bronchodilator Agents; Donepezil; Drug Therapy, Combination; Female; Fluticasone; Food Hypersensitivity; Humans; Indans; Interferons; Latex Hypersensitivity; Letrozole; Mandelic Acids; Middle Aged; Multiple Sclerosis; Nebulizers and Vaporizers; Nitriles; Nootropic Agents; Parasympatholytics; Paresthesia; Piperidines; Respiratory Function Tests; Salmeterol Xinafoate; Thyroxine; Triazoles | 2007 |
[Pulmonary metastases from endometrial stromal sarcoma may benefit from hormone therapy].
Topics: Aromatase Inhibitors; Endometrial Neoplasms; Female; Humans; Letrozole; Lung Neoplasms; Middle Aged; Nitriles; Sarcoma, Endometrial Stromal; Triazoles; Uterine Neoplasms | 2007 |
Reducing endogenous estrogen during development alters hormone production by porcine Leydig cells and seminiferous tubules.
Topics: Age Factors; Animals; Aromatase Inhibitors; Estradiol; Follicle Stimulating Hormone; Inhibins; Letrozole; Leydig Cells; Luteinizing Hormone; Male; Nitriles; Seminiferous Tubules; Swine; Testosterone; Triazoles | 2008 |
Expression of lactoferrin in the boar epididymis: effects of reduced estrogen.
Topics: Animals; Aromatase Inhibitors; Blotting, Western; Epididymis; Estradiol; Gene Expression Regulation; Immunohistochemistry; Lactoferrin; Letrozole; Linear Models; Male; Nitriles; Swine; Testis; Triazoles | 2008 |
Insulin-like growth factor binding proteins IGFBP3, IGFBP4, and IGFBP5 predict endocrine responsiveness in patients with ovarian cancer.
Topics: Antineoplastic Agents; CA-125 Antigen; Cell Line, Tumor; Drug Resistance, Neoplasm; Estradiol; Female; Humans; Immunohistochemistry; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor Binding Protein 4; Insulin-Like Growth Factor Binding Protein 5; Insulin-Like Growth Factor Binding Proteins; Letrozole; Nitriles; Ovarian Neoplasms; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triazoles | 2007 |
Experimental endocrine therapies promote epithelial cytodifferentiation and ciliogenesis in the gerbil female prostate.
Topics: Animals; Body Weight; Cell Differentiation; Cilia; Epithelial Cells; Female; Gerbillinae; Gonadal Steroid Hormones; Hormone Replacement Therapy; Letrozole; Male; Nitriles; Organ Size; Prostate; Testosterone; Triazoles | 2007 |
Cancer research. Budget pressure puts high-profile study in doubt.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Budgets; Controlled Clinical Trials as Topic; Female; Humans; Letrozole; National Institutes of Health (U.S.); Nitriles; Postmenopause; Triazoles; United States | 2007 |
Toxicity of the aromatase inhibitor letrozole to Japanese medaka (Oryzias latipes) eggs, larvae and breeding adults.
Topics: Animals; Aromatase Inhibitors; Dose-Response Relationship, Drug; Endocrine Disruptors; Female; Gonads; Larva; Letrozole; Male; Nitriles; Oryzias; Ovum; Reproduction; Triazoles; Vitellogenins | 2007 |
Progesterone, but not luteal estrogen, is required for the establishment of pregnancy in the new world monkey Cebus apella.
Topics: Animals; Aromatase Inhibitors; Cebus; Embryo Implantation; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Letrozole; Luteal Phase; Male; Mifepristone; Nitriles; Pregnancy; Pregnancy Rate; Pregnancy, Animal; Progesterone; Triazoles | 2007 |
Quantification of carvedilol in human plasma by liquid chromatography using fluorescence detection: application in pharmacokinetic studies.
Topics: Acetonitriles; Administration, Oral; Adrenergic beta-Antagonists; Area Under Curve; Buffers; Calibration; Carbazoles; Carvedilol; Chromatography, Liquid; Drug Stability; Fasting; Freezing; Half-Life; Humans; Hydrogen-Ion Concentration; Letrozole; Male; Metabolic Clearance Rate; Nitriles; Phosphates; Propanolamines; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Temperature; Time Factors; Triazoles | 2007 |
Aromatase inhibitors and male breast cancer.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms, Male; Carcinoma, Ductal, Breast; Combined Modality Therapy; Cyproterone Acetate; Estradiol; Estrogens; Estrogens, Conjugated (USP); Humans; Letrozole; Lymphatic Metastasis; Male; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Phobic Disorders; Progesterone; Receptors, Estrogen; Receptors, Progesterone; Spinal Neoplasms; Testosterone; Treatment Outcome; Triazoles | 2007 |
Focal adhesion kinase and paxillin: novel regulators of brain sexual differentiation?
Topics: Animals; Animals, Newborn; Aromatase; Blotting, Western; Brain; Cells, Cultured; Estradiol; Female; Focal Adhesion Protein-Tyrosine Kinases; Hypothalamus; Immunohistochemistry; Letrozole; Male; Neurites; Nitriles; Paxillin; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Sex Differentiation; Sex Factors; Tamoxifen; Testosterone; Triazoles | 2007 |
Changes in bone mineral density after adjuvant aromatase inhibitors and fracture risk in breast cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Alkaline Phosphatase; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers; Bone Density; Breast Neoplasms; Canada; Chemotherapy, Adjuvant; Collagen Type I; Estrogen Receptor Modulators; Female; Fractures, Bone; Humans; Letrozole; Middle Aged; Nitriles; Peptides; Tamoxifen; Treatment Outcome; Triazoles | 2007 |
Letrozole for ovulation induction and fertility preservation by embryo cryopreservation in young women with endometrial carcinoma.
Topics: Antineoplastic Agents; Cryopreservation; Endometrial Neoplasms; Female; Fertility; Fertilization in Vitro; Humans; Letrozole; Nitriles; Organ Preservation; Ovulation Induction; Pregnancy; Pregnancy Outcome; Prospective Studies; Triazoles | 2007 |
Patients' knowledge and experience of adjuvant endocrine therapy for early breast cancer: a European study.
Topics: Aged; Anastrozole; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Communication Barriers; Decision Making; Europe; Female; Health Knowledge, Attitudes, Practice; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Selective Estrogen Receptor Modulators; Surveys and Questionnaires; Tamoxifen; Triazoles | 2007 |
Clinical evaluation of the use of exemestane as further hormonal therapy after nonsteroidal aromatase inhibitors in postmenopausal metastatic breast cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Treatment Outcome; Triazoles | 2007 |
Limiting access to letrozole--is it justified?
Topics: Aromatase Inhibitors; Female; Heart Defects, Congenital; Humans; Infant, Newborn; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Triazoles | 2007 |
Administration of an inhibitor of estrogen biosynthesis facilitates working memory acquisition in male rats.
Topics: Analysis of Variance; Animals; Aromatase Inhibitors; Behavior, Animal; Choice Behavior; Letrozole; Male; Maze Learning; Memory, Short-Term; Nitriles; Rats; Rats, Sprague-Dawley; Triazoles | 2007 |
Inhibition of the phosphatidylinositol 3-kinase/Akt pathway improves response of long-term estrogen-deprived breast cancer xenografts to antiestrogens.
Topics: Androstadienes; Androstenedione; Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Estrogen Receptor alpha; Estrogen Receptor Modulators; Humans; Letrozole; Mice; Mice, Nude; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Tamoxifen; Triazoles; Wortmannin | 2007 |
Decision making in adjuvant trials in breast cancer: the NCIC CTG MA.17 trial as an example.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Controlled Clinical Trials as Topic; Data Interpretation, Statistical; Disease-Free Survival; Female; Humans; Letrozole; Nitriles; Patient Selection; Research Design; Sample Size; Treatment Outcome; Triazoles | 2008 |
A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome.
Topics: Adipocytes; Androgens; Animals; Aromatase Inhibitors; Body Composition; Body Weight; Dihydrotestosterone; Disease Models, Animal; Estrous Cycle; Female; Letrozole; Magnetic Resonance Imaging; Mesentery; Muscle, Skeletal; Nitriles; Organ Size; Ovary; Polycystic Ovary Syndrome; Rats; Rats, Wistar; Testosterone; Triazoles | 2007 |
[The role of the ovarian steroid aromatase in pathogenesis of reproductive cycles disorders].
Topics: Administration, Oral; Anestrus; Animals; Aromatase; Aromatase Inhibitors; Body Weight; Estrous Cycle; Female; Infertility, Female; Letrozole; Nitriles; Organ Size; Ovary; Rats; Rats, Wistar; Triazoles | 2007 |
Letrozole compared with tamoxifen as initial adjuvant therapy for breast cancer.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Nitriles; Tamoxifen; Treatment Outcome; Triazoles | 2007 |
A novel tocolytic agent: effects of letrozole on gestational length and parturition time.
Topics: Administration, Oral; Animals; Aromatase Inhibitors; Estradiol; Female; Gestational Age; Injections; Labor, Obstetric; Letrozole; Nitriles; Pregnancy; Pregnancy, Prolonged; Rats; Rats, Wistar; Stillbirth; Triazoles | 2007 |
In vitro maturation of germinal vesicle oocytes recovered after premature luteinizing hormone surge: description of a novel approach to fertility preservation.
Topics: Adult; Antineoplastic Agents; Breast Neoplasms; Cell Culture Techniques; Cryopreservation; Drug Administration Schedule; Embryo Culture Techniques; Female; Fertility; Fertility Agents, Female; Fertilization in Vitro; Follicle Stimulating Hormone; Humans; Infertility, Female; Letrozole; Luteinizing Hormone; Nitriles; Oocyte Retrieval; Ovulation; Ovulation Induction; Sperm Injections, Intracytoplasmic; Time Factors; Treatment Outcome; Triazoles | 2008 |
Aromatase inhibitors in the treatment of severe endometriosis.
Topics: Androstadienes; Aromatase Inhibitors; Chronic Disease; Endometriosis; Estrogen Replacement Therapy; Female; Hot Flashes; Humans; Hysterectomy; Letrozole; Middle Aged; Nitriles; Pelvic Pain; Postmenopause; Treatment Outcome; Triazoles | 2007 |
Developmental changes in testicular sensitivity to estrogens throughout fetal and neonatal life.
Topics: Animals; Animals, Newborn; Aromatase Inhibitors; Cell Count; Cells, Cultured; Diethylstilbestrol; Dose-Response Relationship, Drug; Estradiol; Fetal Development; Gestational Age; Letrozole; Leydig Cells; Male; Nitriles; Organ Culture Techniques; Organogenesis; Rats; Rats, Wistar; Spermatozoa; Testis; Triazoles | 2007 |
Letrozole versus clomiphene citrate: which is better for ovulation induction?
Topics: Adult; Aromatase Inhibitors; Clomiphene; Dose-Response Relationship, Drug; Female; Fertility Agents, Female; Humans; Letrozole; Nitriles; Ovulation; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Treatment Outcome; Triazoles | 2009 |
Clinical research. No lifeline for proposed breast cancer prevention trial.
Topics: Antineoplastic Agents; Biomedical Research; Breast Neoplasms; Budgets; Clinical Trials as Topic; Female; Humans; Letrozole; National Institutes of Health (U.S.); Nitriles; Triazoles; United States | 2007 |
Cost-effectiveness of letrozole versus tamoxifen as initial adjuvant therapy in hormone receptor-positive postmenopausal women with early-stage breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Cost-Benefit Analysis; Drug Costs; Female; Humans; Letrozole; Markov Chains; Middle Aged; Models, Econometric; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles | 2007 |
Cost utility analysis of early adjuvant letrozole or anastrozole versus tamoxifen in postmenopausal women with early invasive breast cancer: the UK perspective.
Topics: Anastrozole; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cost-Benefit Analysis; Female; Humans; Letrozole; Markov Chains; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Quality of Life; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles; United Kingdom | 2008 |
NCI and the STELLAR trial.
Topics: Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Female; Humans; Letrozole; National Institutes of Health (U.S.); Nitriles; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Triazoles; United States | 2007 |
Pharmacokinetics of letrozole in male and female rats: influence of complexation with hydroxybutenyl-beta cyclodextrin.
Topics: Administration, Oral; Animals; Antineoplastic Agents; beta-Cyclodextrins; Biological Availability; Capsules; Chemistry, Pharmaceutical; Female; Humans; Injections, Intravenous; Letrozole; Male; Nitriles; Rats; Rats, Sprague-Dawley; Sex Factors; Solubility; Triazoles | 2007 |
Pre-clinical validation of early molecular markers of sensitivity to aromatase inhibitors in a mouse model of post-menopausal hormone-sensitive breast cancer.
Topics: Animals; Aromatase Inhibitors; Biomarkers, Tumor; Biopsy, Needle; Breast Neoplasms; Cyclin D; Cyclins; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Ki-67 Antigen; Letrozole; Mice; Nitriles; Peptides; Postmenopause; Receptors, Estrogen; Trefoil Factor-1; Triazoles | 2008 |
Regression of choroidal metastasis from breast carcinoma following Letrozole therapy.
Topics: Adult; Antineoplastic Agents; Breast Neoplasms; Choroid Neoplasms; Estrogen Receptor Modulators; Female; Fluorescein Angiography; Humans; Letrozole; Nitriles; Remission Induction; Tomography, Optical Coherence; Triazoles | 2007 |
Akt-induced endocrine therapy resistance is reversed by inhibition of mTOR signaling.
Topics: Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Aromatase Inhibitors; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Estradiol; Everolimus; Female; Flow Cytometry; Fulvestrant; Humans; Letrozole; Nitriles; Protein Kinases; Proto-Oncogene Proteins c-akt; Sirolimus; TOR Serine-Threonine Kinases; Triazoles | 2007 |
Role of gonadotropin-releasing hormone analog in the management of male metastatic breast cancer is uncertain.
Topics: Androgens; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms, Male; Goserelin; Humans; Letrozole; Lung Neoplasms; Male; Middle Aged; Nitriles; Triazoles | 2007 |
Hope for axed cancer-prevention trial.
Topics: Breast Neoplasms; Clinical Trials as Topic; Female; Humans; Letrozole; National Institutes of Health (U.S.); Nitriles; Preventive Medicine; Raloxifene Hydrochloride; Triazoles; United States | 2007 |
Clomiphene citrate: an old favourite lives on.
Topics: Anovulation; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitriles; Polycystic Ovary Syndrome; Triazoles | 2007 |
Fetal safety of letrozole and clomiphene citrate for ovulation induction.
Topics: Abnormalities, Drug-Induced; Adult; Aromatase Inhibitors; Birth Weight; Clomiphene; Female; Fertility Agents, Female; Fetus; Gestational Age; Humans; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Outcome; Retrospective Studies; Triazoles | 2007 |
Oestrogen receptors and linear bone growth.
Topics: Animals; Anthropometry; Aromatase Inhibitors; Bone Development; Child; Estrogen Receptor beta; Estrogens; Female; Femur; Growth Disorders; Humans; Letrozole; Male; Mice; Mice, Knockout; Nitriles; Phenotype; Puberty; Testosterone; Triazoles | 2007 |
Letrozole effective in ovarian cancer.
Topics: Antineoplastic Agents; Female; Humans; Letrozole; Nitriles; Ovarian Neoplasms; Triazoles | 2007 |
Role of aromatase inhibitor in patients with poor response to clomiphene citrate needs further evaluation.
Topics: Aromatase Inhibitors; Clomiphene; Female; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Triazoles | 2007 |
Effect of letrozole on urinary bladder function in the female rabbit.
Topics: Animals; Aromatase Inhibitors; Estrogens; Female; Letrozole; Muscle Contraction; Muscle, Smooth; Nitriles; Rabbits; Testosterone; Triazoles; Urinary Bladder | 2007 |
Development and validation of a spectrophotometric method for estimation of letrozole in bulk and pharmaceutical formulation.
Topics: Antineoplastic Agents; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Gas Chromatography-Mass Spectrometry; Letrozole; Nitriles; Reference Standards; Reproducibility of Results; Spectrophotometry, Ultraviolet; Tablets; Triazoles | 2007 |
Sex-specific effects of androgen and estrogen on proliferation of the embryonic chicken hypothalamic neurons.
Topics: Androgens; Animals; Aromatase Inhibitors; Cell Proliferation; Cells, Cultured; Chick Embryo; Estrogens; Female; Flutamide; Hormone Antagonists; Hypothalamus; Letrozole; Male; Neurons; Nitriles; Sex Characteristics; Tamoxifen; Triazoles | 2007 |
Reduced endogenous estrogen delays epididymal development but has no effect on efferent duct morphology in boars.
Topics: Animals; Aromatase Inhibitors; Blotting, Western; Ejaculatory Ducts; Epididymis; Epithelial Cells; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Letrozole; Male; Nitriles; Receptors, Androgen; RNA, Messenger; Swine; Triazoles | 2007 |
Placental villous vascular endothelial growth factor expression and vascularization after estrogen suppression during the last two-thirds of baboon pregnancy.
Topics: Animals; Aromatase Inhibitors; Chorionic Villi; Estradiol; Estrogens; Female; Gene Expression Regulation, Developmental; Letrozole; Neovascularization, Physiologic; Nitriles; Papio anubis; Placental Circulation; Pregnancy; Pregnancy, Animal; RNA, Messenger; Stromal Cells; Triazoles; Trophoblasts; Vascular Endothelial Growth Factor A | 2007 |
A comparison of letrozole to gonadotropins for ovulation induction, in subjects who failed to conceive with clomiphene citrate.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Cohort Studies; Female; Follicle Stimulating Hormone; Humans; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Outcome; Pregnancy Rate; Retrospective Studies; Triazoles | 2007 |
High circulating HER2 extracellular domain levels correlate with reduced efficacy of an aromatase inhibitor in hormone receptor-positive metastatic breast cancer: a confirmatory prospective study.
Topics: Aromatase Inhibitors; Breast Neoplasms; Cohort Studies; Female; Humans; Letrozole; Neoplasm Metastasis; Nitriles; Prospective Studies; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Treatment Outcome; Triazoles | 2007 |
Effects of aromatase inhibitors letrozole and anastrazole on bone metabolism and steroid hormone levels in intact female rats.
Topics: Amino Acids; Anastrozole; Animals; Aromatase Inhibitors; Bone Density; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Female; Letrozole; Nitriles; Osteocalcin; Rats; Testosterone; Triazoles | 2007 |
Gonadal steroid hormones maintain the stress-induced acetylcholine release in the hippocampus: simultaneous measurements of the extracellular acetylcholine and serum corticosterone levels in the same subjects.
Topics: Acetylcholine; Androgen Antagonists; Androgens; Animals; Antineoplastic Agents; Cholinergic Fibers; Corticosterone; Estradiol; Extracellular Space; Female; Flutamide; Gonadal Steroid Hormones; Hippocampus; Letrozole; Male; Nitriles; Orchiectomy; Ovariectomy; Rats; Rats, Wistar; Sex Characteristics; Stress, Physiological; Testosterone; Triazoles | 2008 |
Reducing endogenous estrogens during the neonatal and juvenile periods affects reproductive tract development and sperm production in postpuberal boars.
Topics: Animals; Animals, Newborn; Aromatase Inhibitors; Cell Division; Epididymis; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Letrozole; Male; Mice; Mice, Knockout; Nitriles; Organ Size; Sertoli Cells; Sexual Maturation; Spermatozoa; Swine; Testis; Testosterone; Triazoles | 2008 |
New 7,8-benzoflavanones as potent aromatase inhibitors: synthesis and biological evaluation.
Topics: Anastrozole; Aromatase Inhibitors; Benzene; Cyclization; Flavanones; Humans; Hydrogen Bonding; Letrozole; Microsomes; Molecular Structure; Nitriles; Structure-Activity Relationship; Triazoles | 2008 |
Effects of letrozole on hippocampal and cortical catecholaminergic neurotransmitter levels, neural cell adhesion molecule expression and spatial learning and memory in female rats.
Topics: Animals; Aromatase Inhibitors; Blotting, Western; Catecholamines; Cerebral Cortex; Chromatography, High Pressure Liquid; Densitometry; Dopamine; Electrochemistry; Estradiol; Female; Hippocampus; Learning; Letrozole; Maze Learning; Memory; Neural Cell Adhesion Molecules; Neurotransmitter Agents; Nitriles; Norepinephrine; Organ Size; Ovariectomy; Ovary; Parasympathetic Nervous System; Rats; Space Perception; Triazoles; Uterus; Weight Gain | 2008 |
Predicting response and resistance to endocrine therapy: profiling patients on aromatase inhibitors.
Topics: Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Humans; Letrozole; Nitriles; Oligonucleotide Array Sequence Analysis; Postmenopause; Receptors, Estrogen; Triazoles | 2008 |
Effect of letrozole at 2.5 mg or 5.0 mg/day on ovarian stimulation with gonadotropins in women undergoing intrauterine insemination.
Topics: Abortion, Spontaneous; Adult; Aromatase Inhibitors; Chorionic Gonadotropin; Cost-Benefit Analysis; Drug Administration Schedule; Drug Costs; Drug Therapy, Combination; Endometrium; Female; Fertility Agents, Female; Follicle Stimulating Hormone; Humans; Infertility; Insemination, Artificial; Letrozole; Live Birth; Nitriles; Ovulation; Ovulation Induction; Pregnancy; Pregnancy Rate; Pregnancy, Multiple; Recombinant Proteins; Retrospective Studies; Treatment Outcome; Triazoles; Ultrasonography | 2008 |
Letrozole as adjuvant therapy for postmenopausal women with early breast cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Nitriles; Postmenopause; Triazoles; United States | 2007 |
Effects of letrozole on proliferation and apoptosis in cultured leiomyoma cells treated with prostaglandin E(2).
Topics: Apoptosis; Aromatase Inhibitors; Cell Proliferation; Cells, Cultured; Dinoprostone; Enzyme Activators; Female; Humans; Hysterectomy; Leiomyoma; Letrozole; Nitriles; Triazoles | 2008 |
San Antonio Breast Cancer Symposium.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Deoxycytidine; Docetaxel; Epothilones; Everolimus; Female; Fluorouracil; Humans; Letrozole; Nitriles; Sirolimus; Tamoxifen; Taxoids; Trastuzumab; Triazoles | 2008 |
Preventive effects of letrozole in the model of premenopausal mammary carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Drug Screening Assays, Antitumor; Female; Letrozole; Mammary Neoplasms, Experimental; Menopause; Methylnitrosourea; Nitriles; Rats; Rats, Sprague-Dawley; Triazoles | 2008 |
Selective regulation of neurosteroid biosynthesis in human neuroblastoma cells under hydrogen peroxide-induced oxidative stress condition.
Topics: Aromatase; Aromatase Inhibitors; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Estradiol; Gene Expression Regulation, Neoplastic; Humans; Hydrogen Peroxide; Letrozole; Neuroblastoma; Nitriles; Oxidative Stress; Serum; Steroids; Tetrazolium Salts; Thiazoles; Time Factors; Triazoles | 2008 |
Micellar electrokinetic chromatographic screening of letrozole and its metabolite in human urine: validation and robustness/ruggedness evaluation.
Topics: Aromatase Inhibitors; Benzhydryl Compounds; Chromatography, Micellar Electrokinetic Capillary; Female; Humans; Letrozole; Methanol; Middle Aged; Nitriles; Reproducibility of Results; Triazoles | 2008 |
Joint effects of body size, energy intake, and physical activity on breast cancer risk.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Aromatase Inhibitors; Body Size; Breast Neoplasms; Energy Intake; Energy Metabolism; Female; Humans; Letrozole; Mastectomy, Segmental; Middle Aged; Motor Activity; Neoadjuvant Therapy; Nitriles; Postmenopause; Receptors, Estrogen; Time Factors; Treatment Outcome; Triazoles | 2009 |
A single-nucleotide polymorphism in the aromatase gene is associated with the efficacy of the aromatase inhibitor letrozole in advanced breast carcinoma.
Topics: 3' Untranslated Regions; Aromatase; Aromatase Inhibitors; Breast Neoplasms; DNA, Neoplasm; Female; Humans; Letrozole; Nitriles; Patient Selection; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Postmenopause; Prospective Studies; Triazoles | 2008 |
Effects of letrozole and clomiphene citrate on the expression of HOXA10 and integrin alpha v beta 3 in uterine epithelium of rats.
Topics: Animals; Clomiphene; Epithelial Cells; Female; Gene Expression Regulation; Homeobox A10 Proteins; Homeodomain Proteins; Hysterectomy; Integrin alphaVbeta3; Letrozole; Nitriles; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA; Triazoles; Uterus | 2009 |
Time to remove the subspecialty blinders: breast cancer does not exist in isolation.
Topics: Age Factors; Aged; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cardiovascular Diseases; Cause of Death; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Life Expectancy; Middle Aged; Nitriles; Randomized Controlled Trials as Topic; Risk Factors; Triazoles | 2008 |
Intravenous leiomyomatosis treated with aromatase inhibitor therapy.
Topics: Adult; Angiography; Aromatase Inhibitors; Female; Humans; Leiomyomatosis; Letrozole; Nitriles; Treatment Outcome; Triazoles; Uterine Neoplasms | 2008 |
Micellar electrokinetic chromatographic method for the determination of letrozole, citalopram and their metabolites in human urine.
Topics: Antidepressive Agents, Second-Generation; Antineoplastic Agents; Chromatography, Micellar Electrokinetic Capillary; Citalopram; Humans; Letrozole; Nitriles; Sensitivity and Specificity; Triazoles | 2008 |
Anticancer therapy in patients with porphyrias: evidence today.
Topics: Anastrozole; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Docetaxel; Epoetin Alfa; Erythropoietin; Female; Granulocyte Colony-Stimulating Factor; Hematinics; Humans; Letrozole; Middle Aged; Nitriles; Porphyria, Acute Intermittent; Porphyria, Variegate; Recombinant Proteins; Risk Assessment; Taxoids; Triazoles; Uterine Neoplasms | 2008 |
Joint one-sided and two-sided simultaneous confidence intervals.
Topics: Aromatase Inhibitors; Clinical Trials as Topic; Confidence Intervals; Drug Therapy, Combination; Humans; Letrozole; Models, Statistical; Nitriles; Research Design; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles | 2008 |
Is the use of letrozole to induce ovulation teratogenic?
Topics: Abnormalities, Drug-Induced; Animals; Aromatase Inhibitors; Female; Fertility Agents, Female; Humans; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Outcome; Risk; Triazoles | 2008 |
Controversies in endocrine treatment: effective utilization of steroidal and nonsteroidal aromatase inhibitors: now and in the future. Forward.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Drug Resistance, Neoplasm; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Tamoxifen; Triazoles | 2008 |
Alteration of glyoxalase genes expression in response to testosterone in LNCaP and PC3 human prostate cancer cells.
Topics: Adenocarcinoma; Androgens; Aromatase Inhibitors; Base Sequence; Cell Line, Tumor; Enzyme Induction; Estradiol; Gene Expression Regulation, Neoplastic; Humans; Lactoylglutathione Lyase; Letrozole; Male; Molecular Sequence Data; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Nitriles; Prostatic Neoplasms; Pyruvaldehyde; Response Elements; RNA, Messenger; RNA, Neoplasm; Testosterone; Thiolester Hydrolases; Triazoles | 2007 |
Impact of estrogen deprivation on gene expression profiles of normal postmenopausal breast tissue in vivo.
Topics: Aromatase Inhibitors; Biomarkers, Tumor; Biopsy, Needle; Breast; Breast Neoplasms; Estrogens; Female; Gene Expression Profiling; Genetic Markers; Humans; Letrozole; Middle Aged; Nitriles; Oligonucleotide Array Sequence Analysis; Postmenopause; Triazoles | 2008 |
Letrozole stimulates the growth of human endometrial explants cultured in three-dimensional fibrin matrix.
Topics: Aromatase Inhibitors; Cell Culture Techniques; Cell Division; Dose-Response Relationship, Drug; Endometriosis; Endometrium; Female; Fibrin; Humans; Hysterectomy; Letrozole; Nitriles; Premenopause; Triazoles | 2009 |
[A case of elderly breast cancer achieving partial response by letrozole with stable disease to anastrozole as neoadjuvant endocrine therapy].
Topics: Aged, 80 and over; Anastrozole; Breast Neoplasms; Endocrine System; Female; Humans; Letrozole; Neoadjuvant Therapy; Nitriles; Postmenopause; Tomography, X-Ray Computed; Triazoles; Ultrasonography | 2008 |
Tolerance of adjuvant letrozole outside of clinical trials.
Topics: Aged; Antineoplastic Agents; Aromatase Inhibitors; Arthralgia; Breast Neoplasms; Chemotherapy, Adjuvant; Cohort Studies; Drug Therapy, Combination; Female; Humans; Letrozole; Mastectomy; Middle Aged; Nitriles; Postmenopause; Retrospective Studies; Triazoles | 2008 |
Excellent response to letrozole in brain metastases from breast cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Carcinoma, Ductal; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Letrozole; Lymphatic Metastasis; Middle Aged; Neoplasm Staging; Neoplasms, Hormone-Dependent; Neurologic Examination; Nitriles; Palliative Care; Radiotherapy, Adjuvant; Tomography, X-Ray Computed; Triazoles | 2008 |
Controlling for the EFFECTS related to the underlying pathology of infertility.
Topics: Aromatase Inhibitors; Brain; Clomiphene; Estrogen Antagonists; Estrogens; Female; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Triazoles | 2008 |
Effects of the aromatase inhibitor letrozole on in utero development in rats.
Topics: Animals; Aromatase Inhibitors; Female; Fetal Resorption; Fetal Weight; Letrozole; Maternal Exposure; Nitriles; Organogenesis; Pregnancy; Rats; Rats, Sprague-Dawley; Spine; Triazoles | 2008 |
Letrozole co-treatment in infertile women 40 years old and older receiving controlled ovarian stimulation and intrauterine insemination.
Topics: Adult; Aromatase Inhibitors; Case-Control Studies; Drug Therapy, Combination; Endometriosis; Female; Follicle Stimulating Hormone; Humans; Infertility, Female; Infertility, Male; Insemination, Artificial; Letrozole; Male; Menstrual Cycle; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Outcome; Retrospective Studies; Triazoles | 2009 |
Fertility preservation: a vital survivorship issue for young women with breast cancer.
Topics: Adult; Breast Neoplasms; Chemotherapy, Adjuvant; Enzyme Inhibitors; Female; Follicle Stimulating Hormone; Hormones; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Triazoles | 2008 |
Estrogen receptor (ER) and epidermal growth factor receptor (EGFR) as targets for dual lung cancer therapy: not just a case?
Topics: Adenocarcinoma; Antineoplastic Agents; Diagnosis, Differential; Drug Therapy, Combination; ErbB Receptors; Female; Follow-Up Studies; Gefitinib; Humans; Letrozole; Lung Neoplasms; Middle Aged; Nitriles; Protein Kinase Inhibitors; Quinazolines; Receptors, Estrogen; Skin Neoplasms; Triazoles | 2008 |
MCF-7aro/ERE, a novel cell line for rapid screening of aromatase inhibitors, ERalpha ligands and ERRalpha ligands.
Topics: Anastrozole; Aromatase Inhibitors; Biological Assay; Cell Line, Tumor; Coumarins; ERRalpha Estrogen-Related Receptor; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogens; Fulvestrant; Genes, Reporter; Genistein; Humans; Letrozole; Ligands; Luciferases; Nitriles; Receptors, Estrogen; Response Elements; Tamoxifen; Thiazoles; Transfection; Triazoles | 2008 |
Development, physical characterization, micromeritics and in vitro release kinetics of letrozole loaded biodegradable nanoparticles.
Topics: Antineoplastic Agents; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Excipients; Lactic Acid; Letrozole; Microscopy, Electron, Scanning; Models, Statistical; Nanoparticles; Nitriles; Particle Size; Poloxamer; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Solubility; Triazoles | 2008 |
Stopping treatment can reverse acquired resistance to letrozole.
Topics: Animals; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Cell Proliferation; Drug Resistance, Neoplasm; Estradiol; Estrogen Receptor alpha; Estrogen Receptor Modulators; Female; Humans; Letrozole; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Neoplasms, Hormone-Dependent; Nitriles; Ovariectomy; Phosphorylation; Receptor, ErbB-2; Triazoles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2008 |
Effects of maternal exposure to an aromatase inhibitor on sexual behaviour and neurochemical and endocrine aspects of adult male rat.
Topics: Animals; Aromatase Inhibitors; Biogenic Monoamines; Body Weight; Brain Chemistry; Endocrine System; Female; Letrozole; Male; Maternal Exposure; Nitriles; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Sexual Behavior, Animal; Testosterone; Triazoles | 2008 |
Regression of chronic lymphocytic leukemia with aromatase inhibitor-letrozole?
Topics: Aged; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Leukemia, Lymphocytic, Chronic, B-Cell; Mastectomy, Segmental; Neoplasms, Multiple Primary; Nitriles; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles | 2009 |
Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity.
Topics: Aromatase; Aromatase Inhibitors; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Humans; Letrozole; Molecular Structure; Nitriles; Stereoisomerism; Steryl-Sulfatase; Structure-Activity Relationship; Triazoles | 2008 |
Method to test whether late extended letrozole, rather than self- selection, improves the outcome in patients with breast cancer who have completed 5 years of tamoxifen.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Letrozole; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Placebos; Postmenopause; Survival Rate; Tamoxifen; Treatment Outcome; Triazoles | 2008 |
Preoperative concurrent chemo- and endocrine therapies for women with large operable breast cancer expressing steroid hormone receptors.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Drug Therapy, Combination; Female; Humans; Letrozole; Mastectomy; Middle Aged; Nitriles; Treatment Outcome; Triazoles; Young Adult | 2008 |
The aromatase inhibitor letrozole and inhibitors of insulin-like growth factor I receptor synergistically induce apoptosis in in vitro models of estrogen-dependent breast cancer.
Topics: Apoptosis; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Estrogens; Flow Cytometry; Humans; Letrozole; Neoplasm Metastasis; Nitriles; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Signal Transduction; Triazoles | 2008 |
Dietary genistein negates the inhibitory effect of letrozole on the growth of aromatase-expressing estrogen-dependent human breast cancer cells (MCF-7Ca) in vivo.
Topics: Animals; Aromatase; Aromatase Inhibitors; Base Sequence; Breast Neoplasms; Cell Division; Cell Line, Tumor; Cell Proliferation; Dietary Supplements; DNA Primers; Estradiol; Female; Genistein; Humans; Letrozole; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Hormone-Dependent; Nitriles; Triazoles | 2008 |
Antagonist/letrozole protocol in poor ovarian responders for intracytoplasmic sperm injection: a comparative study with the microdose flare-up protocol.
Topics: Adult; Aromatase Inhibitors; Case-Control Studies; Dose-Response Relationship, Drug; Estradiol; Estriol; Female; Follicle Stimulating Hormone; Humans; Letrozole; Nitriles; Ovarian Follicle; Ovulation Induction; Pregnancy; Pregnancy Outcome; Recombinant Proteins; Retrospective Studies; Sperm Injections, Intracytoplasmic; Triazoles | 2009 |
Screening and management of osteoporosis in breast cancer patients on aromatase inhibitors.
Topics: Absorptiometry, Photon; Adult; Aged; Aged, 80 and over; Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Bone Density Conservation Agents; Bone Diseases, Metabolic; Breast Neoplasms; Female; Humans; Letrozole; Middle Aged; Nitriles; Osteoporosis; Retrospective Studies; Triazoles | 2008 |
Aromatase inhibition during adolescence reduces adult sexual and paternal behavior in the biparental dwarf hamster Phodopus campbelli.
Topics: Age Factors; Algorithms; Animals; Aromatase; Aromatase Inhibitors; Cricetinae; Estradiol; Female; Letrozole; Litter Size; Male; Nesting Behavior; Nitriles; Paternal Behavior; Phodopus; Pregnancy; Reproduction; Sexual Behavior, Animal; Sexual Maturation; Triazoles | 2008 |
Abnormal cervical smear: a sign of disseminated breast cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Carcinoma, Lobular; Female; Humans; Letrozole; Middle Aged; Nitriles; Triazoles; Uterine Cervical Neoplasms; Vaginal Smears | 2008 |
Extending the benefits of adjuvant therapy in early HR+ breast cancer.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Combined Modality Therapy; Female; Humans; Letrozole; Nitriles; Receptors, Estrogen; Receptors, Progesterone; Time Factors; Triazoles | 2008 |
Outcome prediction for estrogen receptor-positive breast cancer based on postneoadjuvant endocrine therapy tumor characteristics.
Topics: Aged; Analysis of Variance; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Disease-Free Survival; Female; Humans; Kaplan-Meier Estimate; Ki-67 Antigen; Letrozole; Lymphatic Metastasis; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Nitriles; Postmenopause; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Receptors, Estrogen; Reproducibility of Results; Risk Assessment; Risk Factors; Tamoxifen; Treatment Outcome; Triazoles | 2008 |
A new therapeutic strategy against hormone-dependent breast cancer: the preclinical development of a dual aromatase and sulfatase inhibitor.
Topics: Administration, Oral; Animals; Aromatase Inhibitors; Azasteroids; Breast Neoplasms; Cell Proliferation; Estrogens; Female; Humans; Letrozole; Mice; Mice, Nude; Neoplasms, Hormone-Dependent; Nitriles; Ovariectomy; Rats; Rats, Wistar; Steryl-Sulfatase; Treatment Outcome; Triazoles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2008 |
Preoperative bevacizumab combined with letrozole and chemotherapy in locally advanced ER- and/or PgR-positive breast cancer: clinical and biological activity.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Breast Neoplasms; Combined Modality Therapy; Female; Humans; Letrozole; Middle Aged; Neoplasm Staging; Nitriles; Preoperative Care; Receptors, Estrogen; Receptors, Progesterone; Triazoles | 2008 |
Sonographic evaluation of endothelial function in letrozole and tamoxifen users.
Topics: Aged; Aromatase Inhibitors; Brachial Artery; Breast Neoplasms; Carotid Artery, External; Case-Control Studies; Endothelium, Vascular; Female; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Tamoxifen; Triazoles; Tunica Intima; Tunica Media; Ultrasonography; Vasodilation | 2008 |
Breast cancer survivors.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Randomized Controlled Trials as Topic; Risk; Time Factors; Triazoles | 2008 |
[Effect of two different doses of letrozole in promoting ovulation in infertile women with polycystic ovarian syndrome].
Topics: Adult; Aromatase Inhibitors; Female; Fertility Agents, Female; Humans; Infertility, Female; Insemination, Artificial; Letrozole; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Triazoles | 2008 |
A case of prolonged disease-free survival in a patient with choroidal metastasis from breast cancer.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Choroid Neoplasms; Disease-Free Survival; Female; Follow-Up Studies; Humans; Letrozole; Middle Aged; Nitriles; Radiotherapy, Adjuvant; Time Factors; Treatment Outcome; Triazoles | 2009 |
Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors.
Topics: Aromatase Inhibitors; Combinatorial Chemistry Techniques; Drug Evaluation, Preclinical; Humans; Imaging, Three-Dimensional; Letrozole; Microsomes; Models, Molecular; Molecular Structure; Nitriles; Steroids; Structure-Activity Relationship; Time Factors; Triazoles | 2009 |
[Clinical analysis of assistant treatment proposals for infertile women with polycystic ovary syndrome].
Topics: Adult; Clomiphene; Embryo Transfer; Female; Fertilization in Vitro; Humans; Infertility, Female; Letrozole; Nitriles; Oocytes; Ovarian Hyperstimulation Syndrome; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Punctures; Reproductive Techniques, Assisted; Retrospective Studies; Treatment Outcome; Triazoles | 2008 |
San Antonio Breast Cancer Symposium.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Breast Neoplasms; Diphosphonates; Everolimus; Female; Humans; Imidazoles; Lapatinib; Letrozole; Nitriles; Quinazolines; Sirolimus; Tamoxifen; Trastuzumab; Triazoles; Zoledronic Acid | 2009 |
Developmental regulation of the expression of the transferrin receptor and Ki67 in oocytes of the baboon fetal ovary by estrogen.
Topics: Animals; Aromatase Inhibitors; Estradiol; Estrogens; Female; Gene Expression Regulation, Developmental; Gestational Age; Immunohistochemistry; Ki-67 Antigen; Letrozole; Nitriles; Oocytes; Ovary; Papio; Pregnancy; Receptors, Transferrin; Triazoles | 2009 |
Cholesterol-promoted synaptogenesis requires the conversion of cholesterol to estradiol in the hippocampus.
Topics: Animals; Animals, Newborn; Aromatase Inhibitors; Cells, Cultured; Cholesterol; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Female; Fulvestrant; Hippocampus; In Vitro Techniques; Letrozole; Male; Microfilament Proteins; Nerve Tissue Proteins; Neurons; Nitriles; Phosphoproteins; Rats; Rats, Wistar; Synapses; Synaptophysin; Triazoles | 2009 |
Determination of the absolute configuration of aromatase and dual aromatase-sulfatase inhibitors by vibrational and electronic circular dichroism spectra analysis.
Topics: Aromatase Inhibitors; Circular Dichroism; Electrons; Halogenation; Letrozole; Models, Molecular; Molecular Conformation; Nitriles; Optical Rotation; Stereoisomerism; Sulfatases; Triazoles; Vibration | 2009 |
A case of Meigs syndrome mimicking metastatic breast carcinoma.
Topics: Antineoplastic Agents; Breast Neoplasms; CA-125 Antigen; Carcinoma, Ductal, Breast; Diagnosis, Differential; Female; Fibroma; Gynecologic Surgical Procedures; Humans; Letrozole; Mastectomy; Meigs Syndrome; Middle Aged; Nitriles; Ovarian Neoplasms; Pleural Effusion; Triazoles | 2009 |
An ER activity profile including ER, PR, Bcl-2 and IGF-IR may have potential as selection criterion for letrozole or tamoxifen treatment of patients with advanced breast cancer.
Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Disease Progression; Disease-Free Survival; Female; Humans; Immunohistochemistry; Letrozole; Microarray Analysis; Middle Aged; Nitriles; Patient Selection; Pilot Projects; Predictive Value of Tests; Proto-Oncogene Proteins c-bcl-2; Receptor, IGF Type 1; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Treatment Outcome; Triazoles | 2009 |
Rapid quantitative analysis of letrozole, fluoxetine and their metabolites in biological and environmental samples by MEKC.
Topics: Chromatography, Micellar Electrokinetic Capillary; Female; Fluoxetine; Humans; Hydrogen-Ion Concentration; Letrozole; Methanol; Nitriles; Reproducibility of Results; Saliva; Sensitivity and Specificity; Solid Phase Extraction; Temperature; Triazoles; Water Pollutants, Chemical; Water Supply | 2009 |
Infusional fluorouracil, epirubicin, and cisplatin followed by weekly paclitaxel plus bevacizumab in locally advanced breast cancer with unfavorable prognostic features.
Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Breast Neoplasms; Carcinoma; Cisplatin; Combined Modality Therapy; Disease-Free Survival; Drug Administration Schedule; Epirubicin; Female; Fluorouracil; Hematologic Diseases; Humans; Hypertension; Infusions, Intravenous; Letrozole; Mastectomy; Middle Aged; Nitriles; Paclitaxel; Prognosis; Proteinuria; Radiotherapy, Adjuvant; Triazoles | 2009 |
Immunomodulation of FOXP3+ regulatory T cells by the aromatase inhibitor letrozole in breast cancer patients.
Topics: Aged; Aged, 80 and over; Aromatase Inhibitors; Breast Neoplasms; Cell Count; Forkhead Transcription Factors; Humans; Letrozole; Middle Aged; Nitriles; Predictive Value of Tests; Prognosis; T-Lymphocytes, Regulatory; Treatment Outcome; Triazoles | 2009 |
Trastuzumab reverses letrozole resistance and amplifies the sensitivity of breast cancer cells to estrogen.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Cell Division; Drug Resistance, Neoplasm; Estrogens; Female; Genes, erbB-2; Humans; Letrozole; Mice; Mice, Nude; Nitriles; Ovariectomy; Transfection; Trastuzumab; Triazoles; Tumor Cells, Cultured | 2009 |
Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4'-methanol-bisbenzonitrile in vitro.
Topics: Antineoplastic Agents; Area Under Curve; Aromatase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Humans; Kinetics; Letrozole; Microsomes, Liver; NADP; Nitriles; Triazoles | 2009 |
Synthesis and PET studies of [(11)C-cyano]letrozole (Femara), an aromatase inhibitor drug.
Topics: Animals; Aromatase; Aromatase Inhibitors; Brain; Carbon Radioisotopes; Female; Isotope Labeling; Letrozole; Nitriles; Papio; Positron-Emission Tomography; Radiopharmaceuticals; Triazoles | 2009 |
Gene expression profiles differentiating between breast cancers clinically responsive or resistant to letrozole.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Biopsy; Breast Neoplasms; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Humans; Letrozole; Neoadjuvant Therapy; Neoplasms, Hormone-Dependent; Nitriles; Oligonucleotide Array Sequence Analysis; Postmenopause; Prospective Studies; Receptors, Estrogen; RNA, Neoplasm; Triazoles | 2009 |
Successful treatment of refractory endometriosis-related chronic pelvic pain with aromatase inhibitors in premenopausal patients.
Topics: Adult; Anastrozole; Aromatase Inhibitors; Chronic Disease; Dose-Response Relationship, Drug; Endometriosis; Estradiol; Female; Follicle Stimulating Hormone; Humans; Letrozole; Luteinizing Hormone; Nitriles; Pelvic Pain; Premenopause; Treatment Outcome; Triazoles; Uterine Diseases | 2009 |
Effectiveness of a letter notification program for women with early-stage breast cancer eligible for extended adjuvant letrozole.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Cohort Studies; Correspondence as Topic; Female; Humans; Letrozole; Middle Aged; Neoplasm Staging; Nitriles; Patient Acceptance of Health Care; Triazoles | 2009 |
The efficacy of hormonal treatment for residual or recurrent low-grade endometrial stromal sarcoma. A retrospective study.
Topics: Adult; Aged, 80 and over; Aromatase Inhibitors; Combined Modality Therapy; Dose-Response Relationship, Drug; Endometrial Neoplasms; Female; Humans; Hysterectomy; Letrozole; Megestrol Acetate; Middle Aged; Nitriles; Progestins; Retrospective Studies; Sarcoma, Endometrial Stromal; Secondary Prevention; Treatment Outcome; Triazoles | 2009 |
Sustained effect of the aromatase inhibitors anastrozole and letrozole on endometrial thickness in patients with endometrial hyperplasia and endometrial carcinoma.
Topics: Aged; Anastrozole; Antineoplastic Agents; Aromatase Inhibitors; Carcinoma; Disease Progression; Endometrial Hyperplasia; Endometrial Neoplasms; Endometrium; Female; Humans; Letrozole; Middle Aged; Neoplasm Metastasis; Nitriles; Organ Size; Retrospective Studies; Time Factors; Triazoles | 2009 |
Porcine hypothalamic aromatase cytochrome P450: isoform characterization, sex-dependent activity, regional expression, and regulation by enzyme inhibition in neonatal boars.
Topics: Analysis of Variance; Animals; Aromatase; Aromatase Inhibitors; Base Sequence; Estradiol; Etomidate; Female; Gene Expression Regulation, Enzymologic; Gonads; Hypothalamus; Isoenzymes; Letrozole; Male; Microsomes; Molecular Sequence Data; Nitriles; Pituitary Gland; Placenta; Recombinant Fusion Proteins; Sequence Alignment; Sex Characteristics; Statistics, Nonparametric; Sus scrofa; Testis; Testosterone; Triazoles | 2009 |
Estrogen promotes germ cell and seminiferous tubule development in the baboon fetal testis.
Topics: Analysis of Variance; Animals; Aromatase Inhibitors; Basement Membrane; Caspase 3; Cell Cycle; Cell Cycle Proteins; Embryonic Stem Cells; Estradiol; Estrogens; Female; Fetal Weight; Follicle Stimulating Hormone; Letrozole; Luteinizing Hormone; Male; Nitriles; Organ Size; Papio anubis; Pregnancy; Random Allocation; Seminiferous Tubules; Sertoli Cells; Spermatogenesis; Spermatozoa; Statistics, Nonparametric; Testis; Testosterone; Triazoles | 2009 |
Effects of binary mixtures of estrogen and antiestrogens on Japanese medaka (Oryzias latipes).
Topics: Animals; Drug Interactions; Endocrine Disruptors; Estradiol; Female; Letrozole; Male; Nitriles; Oryzias; Random Allocation; Reproduction; Statistics, Nonparametric; Tamoxifen; Triazoles; Vitellogenins; Water Pollutants, Chemical | 2009 |
Alfacalcidol prevents aromatase inhibitor (Letrozole)-induced bone mineral loss in young growing female rats.
Topics: Animals; Aromatase Inhibitors; Bone Density; Bone Density Conservation Agents; Bone Development; Bone Resorption; Drug Synergism; Female; Femur; Hydroxycholecalciferols; Letrozole; Nitriles; Rats; Rats, Sprague-Dawley; Triazoles | 2009 |
Accelerated cutaneous nodulosis associated with aromatase inhibitor therapy in a patient with rheumatoid arthritis.
Topics: Aged; Antineoplastic Agents; Aromatase Inhibitors; Arthritis, Rheumatoid; Breast Neoplasms; Female; Hand; Humans; Letrozole; Nitriles; Rheumatoid Nodule; Triazoles | 2009 |
Androgen- and estrogen-independent regulation of copulatory behavior following castration in male B6D2F1 mice.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Animals; Aromatase; Aromatase Inhibitors; Copulation; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogens; Female; Flutamide; Fulvestrant; Letrozole; Male; Mating Preference, Animal; Mice; Nitriles; Orchiectomy; Preoptic Area; Receptors, Androgen; RNA, Messenger; Septal Nuclei; Triazoles | 2009 |
Estrogens regulate humans and rabbit epididymal contractility through the RhoA/Rho-kinase pathway.
Topics: Animals; Endocrine System; Endothelin-1; Epididymis; Estrogen Receptor beta; Estrogens; Genital Diseases, Male; Humans; Hypogonadism; Letrozole; Male; Nitriles; Rabbits; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Testosterone; Triazoles | 2009 |
Reassurance of safety of letrozole and suggested approaches in controlled ovarian hyperstimulation.
Topics: Aromatase Inhibitors; Female; Fertilization in Vitro; Humans; Letrozole; Nitriles; Ovarian Hyperstimulation Syndrome; Ovulation Induction; Reproductive Techniques, Assisted; Safety; Triazoles | 2009 |
Increased androgen receptor and remodeling in the prostatic stroma after the inhibition of 5-alpha reductase and aromatase in gerbil ventral prostate.
Topics: Animals; Aromatase; Cholestenone 5 alpha-Reductase; Enzyme Inhibitors; Estradiol; Finasteride; Gerbillinae; Histocytochemistry; Immunohistochemistry; Letrozole; Male; Nitriles; Prostate; Receptors, Androgen; Testosterone; Triazoles | 2009 |
Luteal support with intravaginal progesterone increases clinical pregnancy rates in women with polycystic ovary syndrome using letrozole for ovulation induction.
Topics: Administration, Intravaginal; Adult; Aromatase Inhibitors; Clomiphene; Female; Humans; Infertility, Female; Insemination, Artificial; Letrozole; Luteal Phase; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Progesterone; Progestins; Retrospective Studies; Triazoles; Young Adult | 2010 |
Use of the aromatase inhibitor letrozole to treat male infertility.
Topics: Adult; Aromatase Inhibitors; Azoospermia; Humans; Letrozole; Male; Nitriles; Spermatogenesis; Treatment Outcome; Triazoles | 2009 |
Differential effects of aromatase inhibitors and antiestrogens on estrogen receptor expression in breast cancer cells.
Topics: Anastrozole; Aromatase Inhibitors; Blotting, Western; Breast Neoplasms; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Fulvestrant; Humans; Letrozole; Neoplasm Staging; Neoplasms, Hormone-Dependent; Nitriles; Prognosis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tamoxifen; Triazoles; Tumor Cells, Cultured | 2009 |
Preservation of fertility in patients with cancer.
Topics: Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Fertility; Humans; Letrozole; Neoplasms; Nitriles; Ovary; Ovulation Induction; Recurrence; Time Factors; Triazoles | 2009 |
Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Anemia, Aplastic; Aromatase Inhibitors; Dyskeratosis Congenita; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogens; Female; Flutamide; Gene Expression Regulation, Enzymologic; Hematopoietic Stem Cells; Heterozygote; Humans; Letrozole; Lymphocytes; Male; Mutation; Nitriles; Receptors, Androgen; Tamoxifen; Telomerase; Triazoles | 2009 |
Sciatic nerve injury induces apoptosis of dorsal root ganglion satellite glial cells and selectively modifies neurosteroidogenesis in sensory neurons.
Topics: Animals; Apoptosis; Aromatase; Aromatase Inhibitors; Cell Survival; Estradiol; Ganglia, Spinal; Letrozole; Male; Neuroglia; Neurotransmitter Agents; Nitriles; Pain; Pain Measurement; Pregnenolone; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sensory Receptor Cells; Time Factors; Triazoles | 2010 |
Promising effect of aromatase inhibitors on recurrent granulosa cell tumors.
Topics: Adult; Aged; Anastrozole; Aromatase Inhibitors; Female; Granulosa Cell Tumor; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Ovarian Neoplasms; Ovariectomy; Prognosis; Treatment Outcome; Triazoles | 2009 |
Aromatase inhibitor for treatment of a recurrent abdominal wall endometrioma in a postmenopausal woman.
Topics: Abdominal Wall; Aromatase Inhibitors; Endometriosis; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Recurrence; Thoracic Diseases; Treatment Outcome; Triazoles | 2009 |
Subdural collections arising from calvarial metastases following discontinuation of anti-angiogenic therapy.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Bone Neoplasms; Breast Neoplasms; Capecitabine; Deoxycytidine; Female; Fluorouracil; Goserelin; Hematoma, Subdural, Intracranial; Humans; Indoles; Letrozole; Leukopenia; Nitriles; Pyrroles; Skull; Sunitinib; Triazoles | 2009 |
Knowledge discovery processing and data mining in karyometry.
Topics: Algorithms; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Papillary; Cell Nucleus; Colonic Neoplasms; Computational Biology; Female; Humans; Karyometry; Letrozole; Neoplasm Recurrence, Local; Nitriles; Precancerous Conditions; Triazoles; Urinary Bladder Neoplasms | 2009 |
Impact of estrogen replacement on letrozole-induced embryopathic effects.
Topics: Abnormalities, Drug-Induced; Animals; Aromatase Inhibitors; Embryo, Mammalian; Estradiol; Estrogen Replacement Therapy; Estrogens; Female; Fetal Development; Fetal Diseases; Letrozole; Male; Maternal Exposure; Nitriles; Rats; Rats, Sprague-Dawley; Triazoles | 2009 |
Letrozole as a booster therapy in growth hormone deficiency.
Topics: Adolescent; Aromatase Inhibitors; Growth Disorders; Growth Hormone; Humans; Letrozole; Male; Nitriles; Triazoles | 2009 |
Analysis of spindle characteristics and embryo quality in mice stimulated with letrozole using Polscope imaging.
Topics: Animals; Blastocyst; Embryo Culture Techniques; Female; Fertility Agents, Female; Fertilization in Vitro; Follicle Stimulating Hormone; Letrozole; Male; Mice; Microscopy, Polarization; Nitriles; Oocytes; Ovulation; Ovulation Induction; Recombinant Proteins; Spindle Apparatus; Time Factors; Triazoles | 2010 |
Effect of vitamin D supplementation on serum 25-hydroxy vitamin D levels, joint pain, and fatigue in women starting adjuvant letrozole treatment for breast cancer.
Topics: Aged; Antineoplastic Agents; Aromatase Inhibitors; Arthralgia; Breast Neoplasms; Chemotherapy, Adjuvant; Cohort Studies; Dietary Supplements; Fatigue; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Treatment Outcome; Triazoles; Vitamin D; Vitamin D Deficiency | 2010 |
[Criteria for evaluating the effectiveness of aromatase inhibitors in the neoadjuvant treatment of patients with endometrial carcinoma].
Topics: Adult; Aged; Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Biomarkers, Tumor; Chemotherapy, Adjuvant; Endometrial Neoplasms; Estradiol; Female; Humans; Ki-67 Antigen; Letrozole; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Nitriles; Receptors, Progesterone; Time Factors; Treatment Outcome; Triazoles | 2009 |
Disruption in the expression and immunolocalisation of steroid receptors and steroidogenic enzymes in letrozole-induced polycystic ovaries in rat.
Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Aromatase; Blotting, Western; Diestrus; Disease Models, Animal; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Follicle Stimulating Hormone; Immunohistochemistry; Letrozole; Luteinizing Hormone; Nitriles; Ovary; Phosphoproteins; Polycystic Ovary Syndrome; Proestrus; Progesterone; Rats; Rats, Wistar; Receptors, Androgen; Receptors, Progesterone; Receptors, Steroid; Testosterone; Triazoles | 2009 |
Long-term potentiation in the rat medial vestibular nuclei depends on locally synthesized 17beta-estradiol.
Topics: Animals; Animals, Newborn; Aromatase Inhibitors; Bicuculline; Biophysics; Drug Interactions; Electric Stimulation; Estradiol; Estrogen Antagonists; Excitatory Amino Acid Antagonists; Fulvestrant; GABA Antagonists; In Vitro Techniques; Letrozole; Long-Term Potentiation; Male; Nitriles; Quinoxalines; Rats; Rats, Wistar; Triazoles; Valine; Vestibular Nuclei | 2009 |
A novel variant of ER-alpha, ER-alpha36 mediates testosterone-stimulated ERK and Akt activation in endometrial cancer Hec1A cells.
Topics: Aromatase Inhibitors; Carcinoma; Cell Membrane; Endometrial Neoplasms; Enzyme Activation; Estrogen Receptor alpha; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Letrozole; Nitriles; Phosphorylation; Protein Isoforms; Proto-Oncogene Proteins c-akt; Signal Transduction; Testosterone; Triazoles; Tumor Cells, Cultured | 2009 |
NCCN Guideline update: Breast Cancer Version 1.2004.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Combined Modality Therapy; Female; Humans; Letrozole; Lymph Nodes; Lymphatic Metastasis; Mastectomy; Neoplasms, Hormone-Dependent; Nitriles; Receptors, Estrogen; Tamoxifen; Triazoles | 2004 |
Evaluation of plasma and tissue estrogen suppression with third-generation aromatase inhibitors: of relevance to clinical understanding?
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Estrogens; Female; Humans; Letrozole; Nitriles; Postmenopause; Triazoles | 2010 |
Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis.
Topics: Anastrozole; Animals; Apoptosis; Aromatase; Aromatase Inhibitors; Ascitic Fluid; Cell Proliferation; Disease Models, Animal; Endometriosis; Endometrium; Female; Letrozole; Mice; Nitriles; Prostaglandins E; Triazoles; Vascular Endothelial Growth Factor A | 2010 |
Potential role of UGT pharmacogenetics in cancer treatment and prevention: focus on tamoxifen and aromatase inhibitors.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Letrozole; Nitriles; Pharmacogenetics; Receptors, Estrogen; Tamoxifen; Triazoles | 2010 |
Hormonal therapy with letrozole prior to surgical management of recurrent metastatic low-grade endometrial stromal sarcoma (LGESS).
Topics: Antineoplastic Agents; Endometrial Neoplasms; Female; Humans; Letrozole; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Nitriles; Sarcoma, Endometrial Stromal; Treatment Outcome; Triazoles | 2009 |
Aromatase inhibitor letrozole in synergy with curcumin in the inhibition of xenografted endometrial carcinoma growth.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Carcinoma; Cell Line, Tumor; Cell Proliferation; Curcumin; Down-Regulation; Drug Synergism; Endometrial Neoplasms; Female; Humans; Letrozole; Mice; Mice, Inbred BALB C; Mice, Nude; Nitriles; Triazoles; Xenograft Model Antitumor Assays | 2009 |
Impact of aromatase inhibitors on bone health in breast cancer patients.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Breast Neoplasms; Calcium; Diphosphonates; Female; Humans; Letrozole; Nitriles; Triazoles; Vitamin D | 2010 |
Feasibility trial of letrozole in combination with bevacizumab in patients with metastatic breast cancer.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Breast Neoplasms; Feasibility Studies; Female; Follow-Up Studies; Humans; Letrozole; Lung Neoplasms; Lymphatic Metastasis; Middle Aged; Neoplasm Staging; Nitriles; Prognosis; Soft Tissue Neoplasms; Survival Rate; Treatment Outcome; Triazoles | 2010 |
Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes.
Topics: Antineoplastic Agents; Aryl Hydrocarbon Hydroxylases; Cross-Linking Reagents; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Genotype; Humans; Ketoconazole; Letrozole; Methoxsalen; Microsomes, Liver; Nitriles; Oxidoreductases; Steroid Hydroxylases; Triazoles | 2009 |
Aromatase inhibition in male breast cancer patients: biological and clinical implications.
Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast Neoplasms, Male; Carcinoma; Estradiol; Humans; Letrozole; Male; Middle Aged; Neoplasm Metastasis; Nitriles; Retrospective Studies; Survival Analysis; Testosterone; Treatment Outcome; Triazoles | 2010 |
The effects of letrozole and melatonin on surgically induced endometriosis in a rat model: a preliminary study.
Topics: Algorithms; Animals; Antineoplastic Agents; Antioxidants; Drug Evaluation, Preclinical; Endometriosis; Female; Gynecologic Surgical Procedures; Letrozole; Melatonin; Nitriles; Pilot Projects; Random Allocation; Rats; Rats, Wistar; Triazoles; Uterine Diseases | 2010 |
Molecular characterization of aromatase inhibitor-resistant, tamoxifen-resistant and LTEDaro cell lines.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles | 2010 |
Musculoskeletal manifestations in patients with malignant disease.
Topics: Adult; Aged; Analysis of Variance; Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Humans; Joint Diseases; Letrozole; Male; Middle Aged; Muscular Diseases; Neoplasms; Nitriles; Osteoporosis; Statistics, Nonparametric; Triazoles | 2010 |
Economic evaluation of zoledronic acid for the prevention of osteoporotic fractures in postmenopausal women with early-stage breast cancer receiving aromatase inhibitors in the UK.
Topics: Aged; Aged, 80 and over; Aromatase Inhibitors; Bone Density; Bone Density Conservation Agents; Breast Neoplasms; Cohort Studies; Cost-Benefit Analysis; Diphosphonates; Female; Humans; Imidazoles; Letrozole; Markov Chains; Middle Aged; Neoplasm Staging; Nitriles; Osteoporosis, Postmenopausal; Quality-Adjusted Life Years; Salvage Therapy; Survival Rate; Treatment Outcome; Triazoles; Zoledronic Acid | 2010 |
Association of BRCA1 mutations with occult primary ovarian insufficiency: a possible explanation for the link between infertility and breast/ovarian cancer risks.
Topics: Adult; Breast Neoplasms; Female; Genes, BRCA1; Humans; Infertility; Letrozole; Mutation; Nitriles; Ovarian Neoplasms; Ovary; Ovulation Induction; Risk; Triazoles | 2010 |
[A case of recurrent breast cancer with extensive liver metastasis successfully treated with endocrine therapy].
Topics: Androstadienes; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Female; Humans; Letrozole; Liver Neoplasms; Medroxyprogesterone; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Tamoxifen; Toremifene; Triazoles | 2009 |
Uterine and fetal blood flow indexes and fetal growth assessment after chronic estrogen suppression in the second half of baboon pregnancy.
Topics: Animals; Aromatase Inhibitors; Blood Pressure; Body Weight; Estradiol; Estrogens; Female; Fetal Development; Fetus; Letrozole; Models, Animal; Nitriles; Papio anubis; Placental Circulation; Pregnancy; Pregnancy, Animal; Regional Blood Flow; Triazoles; Umbilical Arteries; Uterus | 2010 |
Introduction to sessions on guidelines and endocrine therapy, the influence of breast screening on number of mastectomies and the challenge between molecular science and traditional dogma in the treatment of breast cancer. Introduction to Session 6.
Topics: Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast; Breast Neoplasms; Diphosphonates; Female; Humans; Imidazoles; Letrozole; Mass Screening; Mastectomy; Nitriles; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Tamoxifen; Treatment Outcome; Triazoles; Zoledronic Acid | 2009 |
Do BIG1-98 and ZOFAST demand a change in guidelines for endocrine therapy?
Topics: Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Diphosphonates; Female; Humans; Imidazoles; Letrozole; Nitriles; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Tamoxifen; Treatment Outcome; Triazoles; Zoledronic Acid | 2009 |
Retrospective analysis of concurrent vs. sequential administration of radiotherapy and hormone therapy using aromatase inhibitor for hormone receptor-positive postmenopausal breast cancer.
Topics: Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Radiotherapy, Adjuvant; Retrospective Studies; Triazoles | 2009 |
[Inhibiting effect of letrozole combined with curcumin on xenografted endometrial carcinoma growth in nude mice].
Topics: Adenocarcinoma; Animals; Apoptosis; Cell Cycle; Cell Line, Tumor; Curcumin; Drug Synergism; Endometrial Neoplasms; Female; Humans; Letrozole; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Nitriles; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Receptors, Estrogen; RNA, Messenger; Triazoles; Tumor Burden; Xenograft Model Antitumor Assays | 2010 |
Screening of chemicals with anti-estrogenic activity using in vitro and in vivo vitellogenin induction responses in zebrafish (Danio rerio).
Topics: Animals; Cells, Cultured; Endocrine Disruptors; Estrogen Antagonists; Female; Hepatocytes; Letrozole; Male; Nitriles; Tamoxifen; Toxicity Tests; Triazoles; Vitellogenins; Water Pollutants, Chemical; Zebrafish | 2010 |
Sensitivity to the aromatase inhibitor letrozole is prolonged after a "break" in treatment.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Aromatase Inhibitors; Blotting, Western; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Half-Life; Humans; Letrozole; Mice; Mice, Nude; Neoplasm Proteins; Nitriles; Organ Size; Receptor, ErbB-2; Trastuzumab; Triazoles; Tumor Burden; Uterus; Xenograft Model Antitumor Assays | 2010 |
The role of microRNA-128a in regulating TGFbeta signaling in letrozole-resistant breast cancer cells.
Topics: 3' Untranslated Regions; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Estradiol; Female; Gene Expression Profiling; Humans; Letrozole; MicroRNAs; Molecular Sequence Data; Nitriles; Oligonucleotide Array Sequence Analysis; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Testosterone; Transfection; Transforming Growth Factor beta1; Triazoles | 2010 |
Synergistic activity of letrozole and sorafenib on breast cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Inducing Factor; Aromatase; Aromatase Inhibitors; Benzenesulfonates; Breast Neoplasms; Caspase 7; Caspase 9; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Cytochromes c; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Estradiol; Female; Humans; Letrozole; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Niacinamide; Nitriles; Phenylurea Compounds; Phosphoproteins; Phosphorylation; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Proteins; Proto-Oncogene Proteins c-myc; Pyridines; Retinoblastoma Protein; Ribosomal Protein S6 Kinases, 70-kDa; Sorafenib; Testosterone; Time Factors; TOR Serine-Threonine Kinases; Transfection; Triazoles | 2010 |
Aromatase inhibitors induce spine synapse loss in the hippocampus of ovariectomized mice.
Topics: Animals; Aromatase Inhibitors; Down-Regulation; Estrous Cycle; Female; Hippocampus; Letrozole; Mice; Mice, Inbred C57BL; Microfilament Proteins; Nerve Tissue Proteins; Nitriles; Ovariectomy; Synapses; Synaptophysin; Triazoles | 2010 |
Effects of estrogen on breast cancer development: Role of estrogen receptor independent mechanisms.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Female; Fulvestrant; Humans; Letrozole; Mammary Neoplasms, Experimental; Mice; Mice, Knockout; Mice, Transgenic; Nitriles; Ovariectomy; Triazoles; Wnt1 Protein | 2010 |
Effects of letrozole on bone biomarkers and femur fracture in female rats.
Topics: Alkaline Phosphatase; Animals; Aromatase Inhibitors; Biomarkers; Biomechanical Phenomena; Bone and Bones; Calcium; Estradiol; Female; Femoral Fractures; Letrozole; Nitriles; Ovariectomy; Phosphates; Rats; Rats, Sprague-Dawley; Triazoles | 2009 |
Understanding resistance to endocrine agents: molecular mechanisms and potential for intervention.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Hormonal; Aromatase; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Humans; Letrozole; Mice; Mice, Nude; Neoplasms, Hormone-Dependent; Nitriles; Ovariectomy; Receptor, ErbB-2; Signal Transduction; Transfection; Trastuzumab; Triazoles; Xenograft Model Antitumor Assays | 2010 |
The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model.
Topics: Animals; Aromatase Inhibitors; Disease Models, Animal; Endometriosis; Female; Hypoglycemic Agents; Letrozole; Metformin; Nitriles; Omentum; Peritoneal Diseases; Rats; Rats, Wistar; Tissue Adhesions; Triazoles | 2010 |
Radiotherapy, antihormonal therapy, and personalised medicine.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Combined Modality Therapy; Female; Humans; Letrozole; Nitriles; Precision Medicine; Radiation Injuries; Tamoxifen; Triazoles | 2010 |
Formulation and biopharmaceutical evaluation of a transdermal patch containing letrozole.
Topics: Administration, Cutaneous; Analgesics, Opioid; Animals; Chemistry, Pharmaceutical; Drug Compounding; Female; Humans; Letrozole; Male; Mice; Mice, Hairless; Nitriles; Rats; Rats, Wistar; Skin; Skin Absorption; Triazoles | 2010 |
A polymorphism at the 3'-UTR region of the aromatase gene defines a subgroup of postmenopausal breast cancer patients with poor response to neoadjuvant letrozole.
Topics: 3' Untranslated Regions; Aged; Aged, 80 and over; Antineoplastic Agents; Aromatase; Breast Neoplasms; Disease Progression; Female; Humans; Immunohistochemistry; Letrozole; Middle Aged; Neoadjuvant Therapy; Nitriles; Polymorphism, Genetic; Postmenopause; Treatment Outcome; Triazoles | 2010 |
Low-molecular-weight cyclin E can bypass letrozole-induced G1 arrest in human breast cancer cells and tumors.
Topics: Aromatase Inhibitors; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cyclin E; Drug Resistance, Neoplasm; Female; G1 Phase; Humans; Letrozole; Molecular Weight; Nitriles; Postmenopause; Prognosis; Purines; Roscovitine; Triazoles | 2010 |
Combined effects of the bisphosphonate, zoledronic acid and the aromatase inhibitor letrozole on breast cancer cells in vitro: evidence of synergistic interaction.
Topics: Algorithms; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Aromatase Inhibitors; Bone Density Conservation Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Diphosphonates; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Female; Humans; Imidazoles; Letrozole; Nitriles; Triazoles; Zoledronic Acid | 2010 |
Breast cancer drug approved for new indication.
Topics: Antineoplastic Agents; Breast Neoplasms; Drug Administration Schedule; Drug Approval; Drug Therapy, Combination; Female; Humans; Lapatinib; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Quinazolines; Triazoles; United States; United States Food and Drug Administration; Women's Health | 2010 |
Letrozole and norethisterone acetate in colorectal endometriosis.
Topics: Abdominal Pain; Aromatase Inhibitors; Colonic Diseases; Diarrhea; Drug Therapy, Combination; Dyspareunia; Endometriosis; Female; Humans; Letrozole; Nitriles; Norethindrone; Norethindrone Acetate; Pain Measurement; Patient Satisfaction; Pelvic Pain; Pilot Projects; Prospective Studies; Rectal Diseases; Severity of Illness Index; Statistics, Nonparametric; Treatment Outcome; Triazoles | 2010 |
[A case of postoperative liver metastasis of mucinous carcinoma of the breast with complete response to sequential administration of FEC75, tamoxifen citrate, and letrozole].
Topics: Adenocarcinoma, Mucinous; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Epirubicin; Female; Fluorouracil; Humans; Letrozole; Liver Neoplasms; Mastectomy; Middle Aged; Nitriles; Tamoxifen; Triazoles | 2010 |
Cyclin D1 regulates hepatic estrogen and androgen metabolism.
Topics: Androgens; Animals; Aromatase Inhibitors; Cell Line, Tumor; Cyclin D1; Estrogens; Gene Expression Profiling; Gene Expression Regulation; Humans; Letrozole; Liver; Liver Regeneration; Male; Mice; Mice, Inbred BALB C; Nitriles; Triazoles | 2010 |
Letrozole monotherapy in the treatment of uterine myomas.
Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follicular Phase; Humans; Leiomyoma; Letrozole; Multicenter Studies as Topic; Nitriles; Randomized Controlled Trials as Topic; Rats; Triazoles; Uterine Neoplasms | 2010 |
Letrozole inhibits the osteogenesis of medullary bone in prelay pullets.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Aromatase Inhibitors; Bone and Bones; Calcium; Chickens; Estradiol; Female; Isoenzymes; Letrozole; Nitriles; Osteogenesis; Oviposition; Periosteum; Phosphorus; Radiography; Tartrate-Resistant Acid Phosphatase; Testosterone; Triazoles | 2010 |
GnRH agonist trigger for women with breast cancer undergoing fertility preservation by aromatase inhibitor/FSH stimulation.
Topics: Adult; Aromatase Inhibitors; Breast Neoplasms; Female; Fertility; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Humans; Letrozole; Nitriles; Recombinant Proteins; Triazoles | 2010 |
Control of mammary stem cell function by steroid hormone signalling.
Topics: Animals; Aromatase; Aromatase Inhibitors; CD24 Antigen; Cell Count; ErbB Receptors; Estrogens; Female; Humans; Integrin beta1; Integrin beta3; Letrozole; Mammary Glands, Animal; Mice; Nitriles; Ovariectomy; Paracrine Communication; Pregnancy; Pregnancy, Animal; Progesterone; RANK Ligand; Receptors, Estrogen; Receptors, Progesterone; Signal Transduction; Stem Cells; Triazoles | 2010 |
EGFR/HER2 inhibitor AEE788 increases ER-mediated transcription in HER2/ER-positive breast cancer cells but functions synergistically with endocrine therapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase; Breast Neoplasms; Cell Line, Tumor; Cytoprotection; Drug Screening Assays, Antitumor; Drug Synergism; ErbB Receptors; Female; Humans; Letrozole; Mice; Mice, Nude; Neoplasms, Hormone-Dependent; Nitriles; Purines; Receptor, ErbB-2; Receptors, Estrogen; Tamoxifen; Transcription, Genetic; Transfection; Triazoles; Xenograft Model Antitumor Assays | 2010 |
Synthesis and structure-activity relationship studies of pyrazole-based heterocycles as antitumor agents.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Estrogen Receptor Modulators; Female; Heterocyclic Compounds; Humans; Lethal Dose 50; Letrozole; Male; Mice; Nitriles; Pyrazoles; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Triazoles | 2010 |
46,XX/SRY-negative true hermaphrodite.
Topics: Aromatase Inhibitors; Castration; Chromosomes, Human; Gene Deletion; Humans; Letrozole; Male; Nitriles; Ovotesticular Disorders of Sex Development; Sex-Determining Region Y Protein; Triazoles; Young Adult | 2010 |
Erythrocyte alpha-tocopherol in breast cancer patients treated with letrozol.
Topics: Adult; Aged; Aged, 80 and over; alpha-Tocopherol; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cholesterol; Chromatography, High Pressure Liquid; Cohort Studies; Erythrocytes; Female; Follow-Up Studies; Humans; Letrozole; Middle Aged; Nitriles; Tamoxifen; Triazoles | 2010 |
Predictors of non-adherence to aromatase inhibitors among commercially insured women with breast cancer.
Topics: Adult; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Databases as Topic; Delivery of Health Care; Drug Costs; Female; Health Knowledge, Attitudes, Practice; Humans; Insurance, Health; Letrozole; Logistic Models; Medication Adherence; Middle Aged; Nitriles; Odds Ratio; Postmenopause; Retrospective Studies; Risk Assessment; Risk Factors; Treatment Outcome; Triazoles; United States | 2011 |
Letrozole induces hepatotoxicity without causing oxidative stress: the protective effect of melatonin.
Topics: Animals; Antioxidants; Aromatase Inhibitors; Chemical and Drug Induced Liver Injury; Female; Letrozole; Liver; Melatonin; Nitriles; Oxidative Stress; Rats; Rats, Sprague-Dawley; Triazoles | 2011 |
The HDAC inhibitor LBH589 (panobinostat) is an inhibitory modulator of aromatase gene expression.
Topics: Aromatase; Aromatase Inhibitors; Base Sequence; Breast Neoplasms; CCAAT-Enhancer-Binding Protein-delta; Cell Line, Tumor; Cell Proliferation; Coculture Techniques; DNA Primers; Down-Regulation; Drug Synergism; Epigenesis, Genetic; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Indoles; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Panobinostat; Promoter Regions, Genetic; Triazoles | 2010 |
Prolonged survival of neoplastic meningitis from breast cancer with letrozole and intrathecal methotrexate: a case report.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Humans; Injections, Spinal; Letrozole; Meningitis; Methotrexate; Middle Aged; Nitriles; Prognosis; Survival Rate; Triazoles | 2011 |
The transdermal patches for site-specific delivery of letrozole: a new option for breast cancer therapy.
Topics: Administration, Cutaneous; Animals; Antineoplastic Agents; Breast Neoplasms; Female; Letrozole; Mice; Nitriles; Tissue Distribution; Transdermal Patch; Triazoles | 2010 |
Preparation, characterization, and biodistribution of letrozole loaded PLGA nanoparticles in Ehrlich Ascites tumor bearing mice.
Topics: Animals; Aromatase Inhibitors; Carcinoma, Ehrlich Tumor; Drug Carriers; Drug Delivery Systems; Drug Stability; Freeze Drying; Lactic Acid; Letrozole; Mice; Nanoparticles; Nitriles; Particle Size; Pentetic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Technetium; Tissue Distribution; Triazoles | 2010 |
Rheumatoid arthritis and aromatase inhibitors.
Topics: Adenocarcinoma; Aged; Anastrozole; Androstadienes; Aromatase Inhibitors; Arthritis, Rheumatoid; Breast Neoplasms; Carcinoma, Ductal; Combined Modality Therapy; Female; Humans; Letrozole; Middle Aged; Nitriles; Triazoles | 2011 |
Aromatase inhibitors in the treatment of bladder endometriosis.
Topics: Adult; Aromatase Inhibitors; Calcium; Cholecalciferol; Cystectomy; Drug Therapy, Combination; Endometriosis; Female; Humans; Letrozole; Nitriles; Norethindrone; Pain; Treatment Outcome; Triazoles; Urinary Bladder Diseases | 2011 |
Neoadjuvant pegylated liposomal doxorubicin in combination with cisplatin and infusional fluoruracil (CCF) with and without endocrine therapy in locally advanced primary or recurrent breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Doxorubicin; Female; Fluorouracil; Humans; Letrozole; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Neoplasm Staging; Nitriles; Polyethylene Glycols; Receptors, Estrogen; Receptors, Progesterone; Treatment Outcome; Triazoles; Tumor Burden | 2011 |
The differences in outcome between ATAC and BIG 1-98 suggest efficacy differences between these two nonsteroidal AIs.
Topics: Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Female; Humans; Letrozole; Nitriles; Research Design; Tamoxifen; Treatment Outcome; Triazoles | 2010 |
Peripubertal aromatase inhibition in male rats has adverse long-term effects on bone strength and growth and induces prostatic hyperplasia.
Topics: Animals; Aromatase Inhibitors; Bone and Bones; Bone Density; Bone Development; Child; Growth Disorders; Humans; Letrozole; Luteinizing Hormone; Male; Nitriles; Prostate; Prostatic Hyperplasia; Rats; Rats, Wistar; Sexual Maturation; Testis; Triazoles | 2010 |
Biological evidence for dual antiangiogenic-antiaromatase activity of the VEGFR inhibitor PTK787/ZK222584 in vivo.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Aromatase; Aromatase Inhibitors; Cell Line, Tumor; Cell Proliferation; Female; Humans; Immunohistochemistry; Letrozole; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neovascularization, Pathologic; Nitriles; Phthalazines; Pyridines; Receptors, Estrogen; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Triazoles; Xenograft Model Antitumor Assays | 2010 |
Cognitive changes associated with endocrine therapy for breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Case-Control Studies; Chemotherapy, Adjuvant; Cognition; Cognition Disorders; Female; Humans; Letrozole; Memory; Neoplasms, Hormone-Dependent; Nitriles; Prospective Studies; Randomized Controlled Trials as Topic; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles; United States; Women's Health | 2010 |
Sequential changes in gene expression profiles in breast cancers during treatment with the aromatase inhibitor, letrozole.
Topics: Aromatase Inhibitors; Breast Neoplasms; Cluster Analysis; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Letrozole; Nitriles; Prospective Studies; Time Factors; Transcriptome; Treatment Outcome; Triazoles | 2012 |
Bicalutamide and third-generation aromatase inhibitors in testotoxicosis.
Topics: Anastrozole; Androgen Antagonists; Anilides; Aromatase Inhibitors; Child, Preschool; Humans; Letrozole; Male; Nitriles; Puberty, Precocious; Testosterone; Tosyl Compounds; Triazoles | 2010 |
Development and validation of a liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of tamoxifen, anastrozole, and letrozole in human plasma and its application to a clinical study.
Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Breast Neoplasms; Chromatography, Liquid; Female; Humans; Letrozole; Middle Aged; Nitriles; Selective Estrogen Receptor Modulators; Tamoxifen; Tandem Mass Spectrometry; Triazoles | 2010 |
Cost effectiveness of letrozole versus anastrozole in postmenopausal women with HR+ early-stage breast cancer.
Topics: Aged; Anastrozole; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Ductal, Breast; Cost-Benefit Analysis; Drug Substitution; Female; Humans; Letrozole; Middle Aged; Neoplasm Staging; Nitriles; Postmenopause; Receptors, Estrogen; Triazoles; United Kingdom; United States | 2010 |
Evaluation of treatment-effect heterogeneity using biomarkers measured on a continuous scale: subpopulation treatment effect pattern plot.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Female; Humans; Ki-67 Antigen; Letrozole; Models, Statistical; Neoplasms; Nitriles; Outcome Assessment, Health Care; Predictive Value of Tests; Prognosis; Reproducibility of Results; Tamoxifen; Triazoles | 2010 |
The pregnancy outcome of retrieved excess eggs collected during selective follicular reduction from patients with three or more preovulatory follicles undergoing controlled ovarian stimulation and IUI.
Topics: Adult; Embryo Transfer; Female; Humans; Letrozole; Menotropins; Nitriles; Oocyte Retrieval; Ovulation Induction; Pregnancy; Pregnancy Outcome; Pregnancy, Multiple; Sperm Injections, Intracytoplasmic; Triazoles; Vitrification | 2010 |
Down-regulation of heat-shock protein 70 (HSP-70) correlated with responsiveness to neoadjuvant aromatase inhibitor therapy in breast cancer patients.
Topics: Aged; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Down-Regulation; Drug Resistance, Neoplasm; Female; HSP70 Heat-Shock Proteins; Humans; Immunohistochemistry; Ki-67 Antigen; Letrozole; Neoadjuvant Therapy; Nitriles; Randomized Controlled Trials as Topic; Triazoles | 2010 |
Effect of letrozole on plasma lipids, triglycerides, and estradiol in postmenopausal women with metastatic breast cancer.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Estradiol; Estrogens; Female; Humans; Letrozole; Lipids; Middle Aged; Neoplasm Metastasis; Nitriles; Postmenopause; Prospective Studies; Triazoles; Triglycerides | 2010 |
Comparison of aromatase inhibitor (letrozole) and immunomodulators (infliximab and etanercept) on the regression of endometriotic implants in a rat model.
Topics: Animals; Antibodies, Monoclonal; Aromatase Inhibitors; Ascitic Fluid; Disease Models, Animal; Endometriosis; Etanercept; Female; Immunoglobulin G; Immunologic Factors; Infliximab; Letrozole; Nitriles; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Tumor Necrosis Factor; Triazoles; Vascular Endothelial Growth Factor A | 2011 |
Optimal sequence of implied modalities in the adjuvant setting of breast cancer treatment: an update on issues to consider.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Female; Humans; Letrozole; Nitriles; Quality of Life; Radiotherapy; Trastuzumab; Triazoles | 2010 |
Expression of P-450 aromatase, estrogen receptor α and β, and α-inhibin in the fetal baboon testis after estrogen suppression during the second half of gestation.
Topics: Animals; Aromatase; Aromatase Inhibitors; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Female; Gene Expression; Gestational Age; Inhibins; Letrozole; Male; Nitriles; Papio; Pregnancy; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sertoli Cells; Spermatogenesis; Testis; Testosterone; Triazoles | 2011 |
McCune-Albright syndrome (MAS): early and extensive bone fibrous dysplasia involvement and "mistaken identity" oophorectomy.
Topics: Aromatase Inhibitors; Child, Preschool; Female; Fibrous Dysplasia, Polyostotic; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Humans; Letrozole; Luteinizing Hormone; Nitriles; Ovarian Cysts; Ovariectomy; Puberty, Precocious; Triazoles; Ultrasonography; Uterine Hemorrhage | 2010 |
Off-label use of aromatase inhibitors to promote taller stature: is it safe.
Topics: Adolescent; Aromatase Inhibitors; Body Height; Growth Disorders; Humans; Letrozole; Male; Nitriles; Off-Label Use; Triazoles | 2010 |
[Advanced breast cancer in a patient achieving long-term SD after letrozole administration for liver metastasis developing during anastrozole therapy].
Topics: Aged; Anastrozole; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Humans; Letrozole; Liver Neoplasms; Nitriles; Triazoles | 2010 |
Tetra-methoxystilbene modulates ductal growth of the developing murine mammary gland.
Topics: Animals; Aromatase; Aryl Hydrocarbon Hydroxylases; Cell Proliferation; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Estrogens; Female; Letrozole; Mammary Glands, Animal; Mice; Nitriles; Ovariectomy; Stilbenes; Triazoles | 2011 |
Significance of ER-Src axis in hormonal therapy resistance.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Co-Repressor Proteins; Dasatinib; Drug Resistance, Neoplasm; Drug Synergism; Estrogen Receptor alpha; Female; Gene Knockdown Techniques; Humans; Letrozole; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Pyrimidines; Receptor, ErbB-2; RNA Interference; src-Family Kinases; Tamoxifen; Thiazoles; Transcription Factors; Triazoles; Tumor Burden; Xenograft Model Antitumor Assays | 2011 |
Increase in formalin-induced tonic pain by 5alpha-reductase and aromatase inhibition in female rats.
Topics: 5-alpha Reductase Inhibitors; Analgesics, Opioid; Animals; Aromatase Inhibitors; Drug Synergism; Female; Finasteride; Formaldehyde; Letrozole; Morphine; Nitriles; Ovariectomy; Pain; Pain Measurement; Rats; Rats, Wistar; Triazoles | 2011 |
Cyclic estrogenic fluctuation influences synaptic transmission of the medial vestibular nuclei in female rats.
Topics: 5-alpha Reductase Inhibitors; Animals; Aromatase Inhibitors; Diestrus; Electric Stimulation; Estradiol; Female; Finasteride; In Vitro Techniques; Letrozole; Nitriles; Proestrus; Rats; Rats, Wistar; Synaptic Transmission; Triazoles; Vestibular Nuclei | 2011 |
Letrozole plus GnRH analogue as preoperative and adjuvant therapy in premenopausal women with ER positive locally advanced breast cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Chemotherapy, Adjuvant; Disease-Free Survival; Estradiol; Female; Gonadotropin-Releasing Hormone; Humans; Ki-67 Antigen; Letrozole; Middle Aged; Neoadjuvant Therapy; Nitriles; Premenopause; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Retrospective Studies; Treatment Outcome; Triazoles | 2011 |
[Indoleamine 2,3-dioxygenase activity during chemotherapy or hormone therapy in patients with breast cancer].
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Chromatography, High Pressure Liquid; Cyclophosphamide; Epirubicin; Female; Fluorouracil; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Letrozole; Middle Aged; Nitriles; Paclitaxel; Triazoles; Tryptophan | 2010 |
Functional activation of the estrogen receptor-α and aromatase by the HDAC inhibitor entinostat sensitizes ER-negative tumors to letrozole.
Topics: Animals; Antineoplastic Agents; Aromatase; Benzamides; Blotting, Western; Estrogen Receptor alpha; Female; Humans; Immunohistochemistry; Letrozole; Mice; Mice, Nude; Nitriles; Oligonucleotide Array Sequence Analysis; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Triazoles; Up-Regulation; Xenograft Model Antitumor Assays | 2011 |
Aromatase inhibitor-induced loss of grip strength is body mass index dependent: hypothesis-generating findings for its pathogenesis.
Topics: Aged; Anastrozole; Androstadienes; Aromatase Inhibitors; Arthralgia; Body Mass Index; Breast Neoplasms; Cohort Studies; Female; Hand Strength; Humans; Letrozole; Middle Aged; Musculoskeletal Diseases; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Syndrome; Tamoxifen; Triazoles | 2011 |
Transcriptional responses in the brain, liver and gonad of Japanese ricefish (Oryzias latipes) exposed to two anti-estrogens.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Endocrine Disruptors; Estrogen Receptor Modulators; Female; Fish Proteins; Gene Expression Profiling; Gonads; Hypothalamo-Hypophyseal System; Letrozole; Liver; Male; Nitriles; Organ Specificity; Oryzias; RNA, Messenger; Sex Characteristics; Tamoxifen; Toxicity Tests; Transcription, Genetic; Triazoles; Vitellogenins; Water Pollutants, Chemical | 2011 |
Random-start controlled ovarian hyperstimulation for emergency fertility preservation in letrozole cycles.
Topics: Adult; Aromatase Inhibitors; Breast Neoplasms; Carcinoma; Cryopreservation; Drug Administration Schedule; Emergency Medical Services; Female; Fertility; Humans; Infertility, Female; Letrozole; Menstrual Cycle; Nitriles; Oocyte Retrieval; Oocytes; Ovulation Induction; Preservation, Biological; Time Factors; Triazoles | 2011 |
[Eosinophilic colitis associated with letrozole].
Topics: Aged, 80 and over; Antineoplastic Agents; Colitis; Eosinophilia; Female; Humans; Letrozole; Nitriles; Triazoles | 2011 |
A gene expression signature from human breast cancer cells with acquired hormone independence identifies MYC as a mediator of antiestrogen resistance.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chemotherapy, Adjuvant; Disease-Free Survival; Drug Resistance, Neoplasm; Estrogen Receptor Modulators; Female; Gene Expression Profiling; Genetic Association Studies; Humans; Kaplan-Meier Estimate; Ki-67 Antigen; Letrozole; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Nitriles; Oligonucleotide Array Sequence Analysis; Proportional Hazards Models; Proto-Oncogene Proteins c-myc; RNA Interference; Tamoxifen; Treatment Outcome; Triazoles | 2011 |
Synthesis and in vitro studies of biodegradable thiolated chitosan hydrogels for breast cancer therapy.
Topics: Antineoplastic Agents; Breast Neoplasms; Chemistry, Pharmaceutical; Chitosan; Drug Carriers; Drug Stability; Hydrogels; Letrozole; Nanoparticles; Nitriles; Sulfhydryl Compounds; Tensile Strength; Triazoles | 2011 |
[A case of secondary inflammatory breast cancer with multiple metastases in which operation was possible through letrozole monotherapy].
Topics: Antineoplastic Agents; Biopsy, Needle; Carcinoma, Ductal, Breast; Catheter Ablation; Combined Modality Therapy; Female; Humans; Inflammatory Breast Neoplasms; Letrozole; Middle Aged; Neoplasm Metastasis; Nitriles; Positron-Emission Tomography; Triazoles | 2011 |
Binding features of steroidal and nonsteroidal inhibitors.
Topics: Amino Acids; Androgens; Androstadienes; Androstenedione; Aromatase; Aromatase Inhibitors; Binding Sites; Breast Neoplasms; Catalytic Domain; Estrogens; Estrone; Female; Humans; Letrozole; Mutagenesis, Site-Directed; NADPH-Ferrihemoprotein Reductase; Neoplasms, Hormone-Dependent; Nitriles; Protein Conformation; Structure-Activity Relationship; Triazoles | 2011 |
Aromatase inhibitors and xenograft studies.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Aromatase; Aromatase Inhibitors; Benzamides; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Letrozole; Mice; Mice, Nude; Mitogen-Activated Protein Kinase Kinases; Nitriles; Phosphorylation; Pyridines; Receptor, ErbB-2; Receptors, Estrogen; Trastuzumab; Triazoles; Xenograft Model Antitumor Assays | 2011 |
[Significance of HER2 testing in breast cancer].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Ductal, Breast; Drug Delivery Systems; Female; Humans; Letrozole; Nitriles; Receptor, ErbB-2; Survival Rate; Tamoxifen; Trastuzumab; Triazoles | 2011 |
Single nucleotide polymorphisms of CYP19A1 predict clinical outcomes and adverse events associated with letrozole in patients with metastatic breast cancer.
Topics: Adult; Aged; Antineoplastic Agents; Aromatase; Breast Neoplasms; Disease Progression; Female; Humans; Letrozole; Middle Aged; Neoplasm Metastasis; Nitriles; Polymorphism, Single Nucleotide; Triazoles | 2011 |
Estrogen receptor-β activation in combination with letrozole blocks the growth of breast cancer tumors resistant to letrozole therapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Cell Cycle Proteins; Drug Resistance, Neoplasm; Estrogen Receptor beta; Female; Humans; Letrozole; Mice; Mice, Nude; Nitriles; Triazoles; Xenograft Model Antitumor Assays | 2011 |
Use of letrozole challenge test to adjust gonadotropin dose in non-down-regulated cycles.
Topics: Aromatase Inhibitors; Biomarkers; Drug Administration Schedule; Estradiol; Female; Fertility Agents, Female; Follicle Stimulating Hormone, Human; Gonadotropins; Humans; Letrozole; Luteinizing Hormone; Nitriles; Ontario; Ovarian Function Tests; Ovulation; Ovulation Induction; Predictive Value of Tests; Pregnancy; Retrospective Studies; Time Factors; Treatment Outcome; Triazoles | 2011 |
Letrozole and gonadotropins versus luteal estradiol and gonadotropin-releasing hormone antagonist protocol in women with a prior low response to ovarian stimulation.
Topics: Adult; Aromatase Inhibitors; Chi-Square Distribution; Connecticut; Drug Administration Schedule; Estradiol; Female; Fertility Agents, Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone; Gonadotropins; Hormone Antagonists; Humans; Letrozole; Luteal Phase; Nitriles; Oocyte Retrieval; Ovulation; Ovulation Induction; Pregnancy; Pregnancy Rate; Retrospective Studies; Time Factors; Treatment Outcome; Triazoles | 2011 |
Goserelin plus letrozole as first- or second-line hormonal treatment in premenopausal patients with advanced breast cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Disease-Free Survival; Female; Goserelin; Humans; Letrozole; Middle Aged; Nitriles; Premenopause; Treatment Outcome; Triazoles | 2011 |
Letrozole withdrawal response in locally advanced breast cancer.
Topics: Aged; Aromatase Inhibitors; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Hepacivirus; Humans; Letrozole; Liver; Liver Cirrhosis; Nitriles; Triazoles; Withholding Treatment | 2011 |
Anti-Mullerian hormone and antral follicle count as predictors for embryo/oocyte cryopreservation cycle outcomes in breast cancer patients stimulated with letrozole and follicle stimulating hormone.
Topics: Adult; Age Factors; Anti-Mullerian Hormone; Breast Neoplasms; Cryopreservation; Embryonic Development; Female; Fertility Preservation; Follicle Stimulating Hormone; Follicular Fluid; Follow-Up Studies; Humans; Inhibins; Letrozole; Nitriles; Oocytes; Treatment Outcome; Triazoles | 2011 |
Estrogenic regulation of dopaminergic neurons in the opportunistically breeding zebra finch.
Topics: Animals; Aromatase Inhibitors; Dopaminergic Neurons; Estradiol; Female; Finches; Immunohistochemistry; Letrozole; Male; Nitriles; Triazoles; Tyrosine 3-Monooxygenase | 2011 |
Letrozole and gonadotropins versus luteal estradiol and GnRH-antagonist protocol: additional concerns.
Topics: Aromatase Inhibitors; Cost-Benefit Analysis; Drug Administration Schedule; Drug Costs; Estradiol; Female; Fertility Agents, Female; Gonadotropin-Releasing Hormone; Gonadotropins; Hormone Antagonists; Humans; Letrozole; Luteal Phase; Nitriles; Ovulation; Ovulation Induction; Triazoles | 2011 |
Discussion on letrozole-Gn-antagonist group needing an early start of antagonist.
Topics: Aromatase Inhibitors; Drug Administration Schedule; Female; Fertility Agents, Female; Follicle Stimulating Hormone, Human; Gonadotropin-Releasing Hormone; Hormone Antagonists; Humans; Letrozole; Luteinizing Hormone; Nitriles; Ovulation; Ovulation Induction; Time Factors; Triazoles | 2011 |
Aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole and vorozole templates.
Topics: Aromatase; Aromatase Inhibitors; Binding Sites; Catalytic Domain; Cell Line, Tumor; Computer Simulation; Crystallography, X-Ray; Enzyme Activation; Humans; Letrozole; Nitriles; Stereoisomerism; Steryl-Sulfatase; Structure-Activity Relationship; Sulfonic Acids; Triazoles | 2011 |
GP88 (PC-Cell Derived Growth Factor, progranulin) stimulates proliferation and confers letrozole resistance to aromatase overexpressing breast cancer cells.
Topics: Aromatase; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Down-Regulation; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Intercellular Signaling Peptides and Proteins; Letrozole; Nitriles; Progranulins; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Triazoles | 2011 |
Insight into the binding interactions of CYP450 aromatase inhibitors with their target enzyme: a combined molecular docking and molecular dynamics study.
Topics: Aromatase; Aromatase Inhibitors; Catalytic Domain; Computer Simulation; Heterocyclic Compounds; Hydrocarbons, Aromatic; Letrozole; Molecular Dynamics Simulation; Nitriles; Protein Binding; Structure-Activity Relationship; Triazoles | 2012 |
Inhibitory effects of calcitriol on the growth of MCF-7 breast cancer xenografts in nude mice: selective modulation of aromatase expression in vivo.
Topics: Anastrozole; Animals; Aromatase; Aromatase Inhibitors; Calcitriol; Cell Line, Tumor; Cell Proliferation; Estrogens; Female; Humans; Immunohistochemistry; Letrozole; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Nitriles; Real-Time Polymerase Chain Reaction; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Triazoles; Vitamins; Xenograft Model Antitumor Assays | 2011 |
Hormonal, follicular and endometrial dynamics in letrozole-treated versus natural cycles in patients undergoing controlled ovarian stimulation.
Topics: Adult; Aromatase Inhibitors; Endometrium; Female; Fertilization in Vitro; Hormones; Humans; Kinetics; Letrozole; Menstrual Cycle; Nitriles; Ovarian Follicle; Ovulation Induction; Pregnancy; Pregnancy Rate; Retrospective Studies; Triazoles | 2011 |
Letrozole or clomiphene citrate as first line for anovulatory infertility: a debate.
Topics: Anovulation; Aromatase Inhibitors; Clomiphene; Drug Resistance; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Randomized Controlled Trials as Topic; Triazoles | 2011 |
A bovine model for examining the effects of an aromatase inhibitor on ovarian function in women.
Topics: Animals; Aromatase; Aromatase Inhibitors; Biomarkers; Cattle; Corpus Luteum; Drug Administration Schedule; Estradiol; Estrous Cycle; Female; Follicle Stimulating Hormone; Humans; Letrozole; Luteinizing Hormone; Models, Animal; Nitriles; Ovarian Follicle; Ovary; Progesterone; Time Factors; Triazoles; Ultrasonography | 2011 |
Synthesis and structure-activity relationship of 1- and 2-substituted-1,2,3-triazole letrozole-based analogues as aromatase inhibitors.
Topics: Aromatase Inhibitors; Cell Line, Tumor; Cell Proliferation; Computer Simulation; Humans; Inhibitory Concentration 50; Letrozole; Magnetic Resonance Spectroscopy; Mass Spectrometry; Nitriles; Structure-Activity Relationship; Triazoles | 2011 |
Preliminary study of letrozole use for improving spermatogenesis in non-obstructive azoospermia patients with normal serum FSH.
Topics: Aromatase Inhibitors; Azoospermia; Estradiol; Follicle Stimulating Hormone; Humans; Letrozole; Male; Nitriles; Sperm Count; Spermatogenesis; Testosterone; Triazoles | 2011 |
Effective role of hormonal therapy in metastatic primary neuroendocrine breast carcinoma.
Topics: Aromatase Inhibitors; Breast Neoplasms; Carcinoma, Neuroendocrine; Diagnosis, Differential; Female; Humans; Letrozole; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Nitriles; Pancreatic Neoplasms; Receptors, Estrogen; Receptors, Progesterone; Triazoles | 2011 |
The effects of metformin and letrozole on endometrium and ovary in a rat model.
Topics: Animals; Aromatase Inhibitors; Cell Count; Dose-Response Relationship, Drug; Drug Combinations; Drug Evaluation, Preclinical; Endometrium; Female; Fertility Agents, Female; Hypoglycemic Agents; Letrozole; Metformin; Models, Animal; Nitriles; Organ Size; Ovary; Rats; Rats, Wistar; Triazoles | 2011 |
Hyaluronic acid-bound letrozole nanoparticles restore sensitivity to letrozole-resistant xenograft tumors in mice.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Drug Resistance, Neoplasm; Flow Cytometry; Hyaluronic Acid; Letrozole; Mice; Microscopy, Electron, Scanning; Nanoparticles; Nitriles; RNA Interference; Triazoles; Xenograft Model Antitumor Assays | 2011 |
Inhibition of oestrogen biosynthesis induces mild anxiety in C57BL/6J ovariectomized female mice.
Topics: Animals; Anxiety; Aromatase Inhibitors; Depression; Disease Models, Animal; Estradiol; Female; Hippocampus; Humans; Immobility Response, Tonic; Learning; Letrozole; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Motor Activity; Nitriles; Ovariectomy; Triazoles | 2011 |
The tamoxifen metabolite norendoxifen is a potent and selective inhibitor of aromatase (CYP19) and a potential lead compound for novel therapeutic agents.
Topics: Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Binding Sites; Breast Neoplasms; Catalytic Domain; Computer Simulation; Drug Discovery; Female; Humans; Isoenzymes; Kinetics; Letrozole; Microsomes; Models, Molecular; Nitriles; Tamoxifen; Testosterone; Thermodynamics; Triazoles | 2012 |
Body mass index-associated differences in response to ovulation induction with letrozole.
Topics: Adult; Alabama; Aromatase Inhibitors; Body Mass Index; Chi-Square Distribution; Female; Fertility Agents, Female; Humans; Infertility, Female; Insemination, Artificial; Letrozole; Logistic Models; Nitriles; Obesity; Odds Ratio; Ovary; Ovulation; Ovulation Induction; Pregnancy; Pregnancy Rate; Retrospective Studies; Treatment Outcome; Triazoles | 2011 |
[Lymphangioleiomyomatosis: new therapeutic approaches].
Topics: Adult; Aromatase Inhibitors; Clinical Trials, Phase II as Topic; Doxycycline; Estrogen Receptor Modulators; Female; Humans; Letrozole; Lung Neoplasms; Lung Transplantation; Lymphangioleiomyomatosis; Matrix Metalloproteinase Inhibitors; Multicenter Studies as Topic; Nitriles; Randomized Controlled Trials as Topic; Registries; Sirolimus; Spain; Therapies, Investigational; Triazoles | 2011 |
Is primary endocrine therapy effective in treating the elderly, unfit patient with breast cancer?
Topics: Aged; Aged, 80 and over; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Breast Neoplasms; Disease Progression; Female; Humans; Letrozole; Middle Aged; Nitriles; Receptors, Estrogen; Retrospective Studies; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles | 2011 |
Transcriptional responses in Japanese medaka (Oryzias latipes) exposed to binary mixtures of an estrogen and anti-estrogens.
Topics: Animals; Biomarkers; Complex Mixtures; Dose-Response Relationship, Drug; Endocrine Disruptors; Endocrine System; Estrogen Receptor Modulators; Estrogens; Ethinyl Estradiol; Female; Gene Expression Profiling; Hypothalamo-Hypophyseal System; Letrozole; Male; Nitriles; Oryzias; Random Allocation; Sex Factors; Tamoxifen; Transcription, Genetic; Triazoles; Water Pollutants, Chemical | 2011 |
Low residual proliferation after short-term letrozole therapy is an early predictive marker of response in high proliferative ER-positive breast cancer.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Biomarkers, Pharmacological; Biomarkers, Tumor; Breast Neoplasms; Carcinoma; Cell Proliferation; Cell Survival; Early Detection of Cancer; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Letrozole; Microarray Analysis; Middle Aged; Neoplasm, Residual; Nitriles; Prognosis; Receptors, Estrogen; Time Factors; Triazoles | 2011 |
Does the addition of clomiphene citrate or letrazole to gonadotropin treatment enhance the oocyte yield in poor responders undergoing IVF?
Topics: Adult; Birth Rate; Clomiphene; Embryo Transfer; Estradiol; Estrogen Antagonists; Female; Fertilization in Vitro; Follicle Stimulating Hormone; Gonadotropins; Hormone Antagonists; Humans; Letrozole; Nitriles; Oocytes; Ovarian Follicle; Ovulation Induction; Pregnancy; Pregnancy Rate; Retrospective Studies; Triazoles | 2011 |
Bone mineral density in breast cancer patients treated with adjuvant letrozole, tamoxifen, or sequences of letrozole and tamoxifen in the BIG 1-98 study (SAKK 21/07).
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bone Density; Breast Neoplasms; Female; Hip; Humans; Letrozole; Lumbar Vertebrae; Middle Aged; Multivariate Analysis; Nitriles; Osteoporosis; Postmenopause; Radiography; Randomized Controlled Trials as Topic; Retrospective Studies; Tamoxifen; Triazoles | 2012 |
Choroidal and optic disc metastases from breast cancer and their response to combination pharmacotherapy with tamoxifen, cyclophosphamide hydrate, letrozole, and bevacizumab.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Breast Neoplasms; Choroid Neoplasms; Cyclophosphamide; Female; Humans; Letrozole; Middle Aged; Nitriles; Optic Disk; Optic Nerve Neoplasms; Retinal Detachment; Tamoxifen; Treatment Outcome; Triazoles | 2012 |
Hormone treatment without surgery for patients aged 75 years or older with operable breast cancer.
Topics: Aged; Aged, 80 and over; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Disease Progression; Female; Follow-Up Studies; Humans; Letrozole; Nitriles; Receptor, ErbB-2; Survival Rate; Tamoxifen; Treatment Outcome; Triazoles | 2012 |
Use of the aromatase inhibitor letrozole for ovulation induction in women with polycystic ovarian syndrome.
Topics: Anovulation; Aromatase Inhibitors; Clomiphene; Congenital Abnormalities; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Outcome; Triazoles | 2011 |
Drugs for ovulation induction.
Topics: Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Insemination, Artificial; Letrozole; Male; Nitriles; Ovulation; Ovulation Induction; Triazoles | 2011 |
Dual IGF-1R/InsR inhibitor BMS-754807 synergizes with hormonal agents in treatment of estrogen-dependent breast cancer.
Topics: Animals; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Estradiol; Estrogens; Female; Fulvestrant; Gene Expression Profiling; Humans; Letrozole; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Nitriles; Oligonucleotide Array Sequence Analysis; Pyrazoles; Receptor, IGF Type 1; Receptor, Insulin; Tamoxifen; Triazines; Triazoles; Xenograft Model Antitumor Assays | 2011 |
Neoadjuvant chemotherapy and targeted therapies: a promising strategy.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; DNA Repair; Drug Discovery; Everolimus; Female; Genetic Predisposition to Disease; Humans; Lapatinib; Letrozole; Molecular Targeted Therapy; Neoadjuvant Therapy; Nitriles; Quinazolines; Randomized Controlled Trials as Topic; Receptor, ErbB-2; Receptors, Estrogen; Sirolimus; Trastuzumab; Triazoles | 2011 |
Diagnosis and management of precocious puberty in atypical presentations of McCune-Albright syndrome: a case series review.
Topics: Aromatase Inhibitors; Child, Preschool; Diagnosis, Differential; Female; Fibrous Dysplasia, Polyostotic; Gonadotropin-Releasing Hormone; Humans; Letrozole; Nitriles; Puberty, Precocious; Triazoles | 2012 |
Lobular carcinoma of the breast metastasizing to leiomyoma in a patient under letrozole treatment.
Topics: Aromatase Inhibitors; Breast Neoplasms; Carcinoma, Lobular; Female; Humans; Leiomyoma; Letrozole; Middle Aged; Neoplasms, Multiple Primary; Nitriles; Triazoles; Uterine Neoplasms | 2011 |
Early operable breast cancer in elderly women treated with an aromatase inhibitor letrozole as sole therapy.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Female; Fractures, Bone; Humans; Letrozole; Middle Aged; Nitriles; Survival Analysis; Triazoles | 2011 |
Antitumor activity of chemoendocrine therapy in premenopausal and postmenopausal models with human breast cancer xenografts.
Topics: Animals; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase; Breast Neoplasms; Capecitabine; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Female; Fluorouracil; Genes, Reporter; Humans; Letrozole; Mice; Mice, Inbred BALB C; Mice, Nude; Nitriles; Postmenopause; Premenopause; Tamoxifen; Thymidine Phosphorylase; Triazoles; Xenograft Model Antitumor Assays | 2012 |
Mechanistic links between oxidative/nitrosative stress and tumor necrosis factor alpha in letrozole-induced murine polycystic ovary: biochemical and pathological evidences for beneficial effect of pioglitazone.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Aromatase Inhibitors; Estradiol; Female; Hypoglycemic Agents; Letrozole; Lipid Peroxidation; Nitriles; Oxidative Stress; Pioglitazone; Polycystic Ovary Syndrome; PPAR gamma; Progesterone; Prostaglandins E; Rats; Rats, Wistar; Testosterone; Thiazolidinediones; Triazoles; Tumor Necrosis Factor-alpha | 2012 |
Severe ovarian hyperstimulation syndrome after letrozole-gonadotropin stimulation: a case report.
Topics: Adult; Breast Neoplasms; Female; Fertilization in Vitro; Gonadotropins; Humans; Letrozole; Male; Nitriles; Oocytes; Ovarian Hyperstimulation Syndrome; Ovulation Induction; Sperm Injections, Intracytoplasmic; Triazoles | 2012 |
Controlled ovarian hyperstimulation in women with polycystic ovarian syndrome with or without intrauterine insemination.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Cohort Studies; Female; Fertility Agents, Female; Gonadotropins; Humans; Infertility, Female; Insemination, Artificial; Letrozole; Nitriles; Ovarian Hyperstimulation Syndrome; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Quebec; Retrospective Studies; Selective Estrogen Receptor Modulators; Sexual Behavior; Triazoles | 2012 |
Opposing effects of Runx2 and estradiol on breast cancer cell proliferation: in vitro identification of reciprocally regulated gene signature related to clinical letrozole responsiveness.
Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Clinical Trials, Phase II as Topic; Core Binding Factor Alpha 1 Subunit; Drug Resistance, Neoplasm; Estradiol; Female; Fluorescent Antibody Technique; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; High-Throughput Nucleotide Sequencing; Humans; Letrozole; Nitriles; Real-Time Polymerase Chain Reaction; Signal Transduction; Triazoles | 2012 |
17β-Estradiol regulates cyclin A1 and cyclin B1 gene expression in adult rat seminiferous tubules.
Topics: Animals; Aromatase Inhibitors; Cyclin A1; Cyclin B1; Estradiol; Estrogen Antagonists; Fulvestrant; Gene Expression; Letrozole; Male; Nitriles; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Seminiferous Tubules; Spermatogenesis; Triazoles | 2012 |
[A case of an elderly breast cancer patient achieving partial response with toremifene without efficacy of letrozole as a preoperative primary endocrine therapy].
Topics: Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Biopsy; Breast Neoplasms; Female; Humans; Letrozole; Neoadjuvant Therapy; Nitriles; Salvage Therapy; Toremifene; Triazoles | 2011 |
[Long-term follow-up study: indolemamine 2,3-dioxygenase activity during chemotherapy or hormone therapy in patients with breast cancer].
Topics: Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy; Cyclophosphamide; Epirubicin; Female; Fluorouracil; Follow-Up Studies; Hormone Replacement Therapy; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Letrozole; Middle Aged; Nitriles; Paclitaxel; Time Factors; Triazoles | 2011 |
[A case of scalp metastases from breast cancer successfully treated with letrozole].
Topics: Antineoplastic Agents; Biopsy; Breast Neoplasms; Female; Head and Neck Neoplasms; Humans; Letrozole; Magnetic Resonance Imaging; Middle Aged; Neoplasm Staging; Nitriles; Scalp; Skin Neoplasms; Triazoles | 2011 |
Primary breast cancer of the vulva: a case report.
Topics: Adenocarcinoma; Aged, 80 and over; Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Female; Histocytochemistry; Humans; Immunohistochemistry; Letrozole; Nitriles; Radiotherapy; Triazoles; Vulva; Vulvar Neoplasms | 2012 |
Myocardial infarction due to coronary thrombus formation in a postmenopausal woman with breast cancer after initiation of letrozol therapy.
Topics: Aromatase Inhibitors; Breast Neoplasms; Coronary Thrombosis; Electrocardiography; Female; Humans; Letrozole; Middle Aged; Myocardial Infarction; Nitriles; Postmenopause; Radiography; Triazoles | 2012 |
Endometrial receptivity defects during IVF cycles with and without letrozole.
Topics: Adult; Aromatase Inhibitors; Birth Rate; Embryo Implantation; Endometrium; Female; Fertilization in Vitro; Humans; Infertility, Female; Integrin alphaVbeta3; Letrozole; Nitriles; Pregnancy; Pregnancy Rate; Retrospective Studies; Triazoles | 2012 |
Testis morphology in rats chronically treated with letrozole, an aromatase inhibitor.
Topics: Animals; Aromatase; Aromatase Inhibitors; Letrozole; Leydig Cells; Male; Nitriles; Rats; Rats, Wistar; Seminiferous Epithelium; Testis; Triazoles | 2011 |
Deep time: the long and the short of adjuvant endocrine therapy for breast cancer.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles | 2012 |
Aromatase activity after a short-course of letrozole administration in adult men at sea level and at high altitude (with or without excessive erythrocytosis).
Topics: Adult; Altitude; Androstenedione; Aromatase; Aromatase Inhibitors; Cohort Studies; Dehydroepiandrosterone Sulfate; Estradiol; Hemoglobins; Humans; Letrozole; Male; Middle Aged; Nitriles; Oximetry; Peru; Polycythemia; Prospective Studies; Statistics, Nonparametric; Testosterone; Triazoles | 2012 |
Outcome of metformin treatment in polycystic ovary syndrome.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Therapy, Combination; Estrogen Antagonists; Female; Humans; Hypoglycemic Agents; Letrozole; Menstrual Cycle; Metformin; Nitriles; Polycystic Ovary Syndrome; Treatment Outcome; Triazoles; Young Adult | 2012 |
High yield of oocytes without an increase in circulating estradiol levels in breast cancer patients treated with follicle-stimulating hormone and aromatase inhibitor in standard gonadotropin-releasing hormone analogue protocols.
Topics: Adult; Aromatase Inhibitors; Breast Neoplasms; Clinical Protocols; Embryo Implantation, Delayed; Estradiol; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Humans; Letrozole; Neoadjuvant Therapy; Nitriles; Oocytes; Ovary; Reproductive Techniques, Assisted; Retrospective Studies; Treatment Outcome; Triazoles | 2011 |
[A case of liver metastasis of breast cancer responding to letrozole].
Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Humans; Letrozole; Liver Neoplasms; Nitriles; Tomography, X-Ray Computed; Triazoles | 2012 |
Simultaneous quantitative analysis of letrozole, its carbinol metabolite, and carbinol glucuronide in human plasma by LC-MS/MS.
Topics: Antineoplastic Agents; Calibration; Chromatography, Liquid; Humans; Letrozole; Limit of Detection; Nitriles; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Triazoles | 2012 |
Stimulation of Sertoli cell proliferation: defining the response interval to an inhibitor of estrogen synthesis in the boar.
Topics: Animals; Aromatase Inhibitors; Cell Proliferation; Estrogens; Letrozole; Male; Nitriles; Sertoli Cells; Sexual Maturation; Sus scrofa; Triazoles | 2012 |
CYP2D6 genotype as a marker for benefit of adjuvant tamoxifen in postmenopausal women: lessons learned.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cytochrome P-450 CYP2D6; Female; Glucuronosyltransferase; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Polymorphism, Single Nucleotide; Postmenopause; Tamoxifen; Triazoles | 2012 |
[Effectiveness of aromatase inhibitors in comparison with metformin for neoadjuvant treatment in patients with endometrial cancer].
Topics: Adult; Aged; Anastrozole; Androstadienes; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Endometrial Neoplasms; Female; Glucose; Humans; Hypoglycemic Agents; Ki-67 Antigen; Letrozole; Metformin; Middle Aged; Neoadjuvant Therapy; Neoplasm Grading; Nitriles; Treatment Outcome; Triazoles | 2011 |
L-BLP25 vaccine plus letrozole induces a TH1 immune response and has additive antitumor activity in MUC1-expressing mammary tumors in mice.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Cancer Vaccines; Cyclophosphamide; Estradiol; Estrogen Antagonists; Female; Interferon-gamma; Interleukin-12; Letrozole; Mammary Neoplasms, Animal; Membrane Glycoproteins; Mice; Mucin-1; Neoplasms, Hormone-Dependent; Nitriles; Random Allocation; Tamoxifen; Th1 Cells; Triazoles | 2012 |
What is the optimal follicular size before triggering ovulation in intrauterine insemination cycles with clomiphene citrate or letrozole? An analysis of 988 cycles.
Topics: Adult; Chi-Square Distribution; Chorionic Gonadotropin; Clomiphene; Drug Administration Schedule; Drug Therapy, Combination; Endometrium; Female; Fertility Agents, Female; Humans; Infertility; Insemination, Artificial; Letrozole; Logistic Models; Male; Multivariate Analysis; Nitriles; Ovarian Follicle; Ovulation; Ovulation Induction; Pregnancy; Pregnancy Rate; Retrospective Studies; Time Factors; Treatment Outcome; Triazoles; Ultrasonography; Wisconsin | 2012 |
Overcoming acquired resistance to letrozole by targeting the PI3K/AKT/mTOR pathway in breast cancer cell clones.
Topics: Aged; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Everolimus; Female; Humans; Imidazoles; Immunosuppressive Agents; Letrozole; Neoadjuvant Therapy; Nitriles; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinolines; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Triazoles | 2012 |
A pilot study of letrozole for one year in women at enhanced risk of developing breast cancer: effects on mammographic density.
Topics: Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Mammography; Nitriles; Pilot Projects; Risk Factors; Triazoles | 2012 |
The effects of letrozole on ovarian stimulation for fertility preservation in cancer-affected women.
Topics: Adult; Antineoplastic Agents; Breast Neoplasms; Cryopreservation; Estradiol; Female; Fertility Preservation; Gonadotropin-Releasing Hormone; Humans; Letrozole; Menstrual Cycle; Nitriles; Oocyte Retrieval; Ovary; Ovulation Induction; Prospective Studies; Retrospective Studies; Triazoles | 2012 |
Evaluation of anticancer drug-loaded nanoparticle characteristics by nondestructive methodologies.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Calibration; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Drug Carriers; Emulsifying Agents; Lactic Acid; Least-Squares Analysis; Letrozole; Linear Models; Models, Chemical; Models, Statistical; Nanoparticles; Nanotechnology; Nitriles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Principal Component Analysis; Quality Control; Spectroscopy, Near-Infrared; Technology, Pharmaceutical; Triazoles | 2012 |
Molecular mechanisms of a novel selenium-based complementary medicine which confers protection against hyperandrogenism-induced polycystic ovary.
Topics: Animals; Antioxidants; Biomarkers; Estradiol; Female; Hyperandrogenism; Letrozole; Lipid Peroxidation; Nitriles; Ovary; Oxidative Stress; Plant Extracts; Polycystic Ovary Syndrome; Progesterone; Prostaglandins E; Rats; Rats, Wistar; Selenium; Testosterone; Triazoles; Tumor Necrosis Factor-alpha | 2012 |
AIB1:ERα transcriptional activity is selectively enhanced in aromatase inhibitor-resistant breast cancer cells.
Topics: Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Disease-Free Survival; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; JNK Mitogen-Activated Protein Kinases; Letrozole; MAP Kinase Signaling System; Neoplasm Recurrence, Local; Nitriles; Nuclear Receptor Coactivator 3; Promoter Regions, Genetic; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-myc; Transcription, Genetic; Trefoil Factor-1; Triazoles; Tumor Suppressor Proteins; Up-Regulation | 2012 |
Effect of letrozole on estradiol production and P450 aromatase messenger RNA expression of cultured luteinized granulosa cells from women with and without endometriosis.
Topics: Aromatase; Aromatase Inhibitors; Case-Control Studies; Cells, Cultured; Endometriosis; Estradiol; Female; Gene Expression Regulation, Enzymologic; Granulosa Cells; Humans; Letrozole; Luteinization; Nitriles; Ovarian Diseases; Primary Cell Culture; RNA, Messenger; Triazoles | 2012 |
Combination of acupuncture and chinese medicinal herbs in treating model rats with polycystic ovary syndrome.
Topics: Acupuncture Therapy; Administration, Oral; Animals; Benzofurans; Chromatography, High Pressure Liquid; Disease Models, Animal; Drugs, Chinese Herbal; Enzyme-Linked Immunosorbent Assay; Female; Follicle Stimulating Hormone; Letrozole; Luteinizing Hormone; Nitriles; Polycystic Ovary Syndrome; Rats; Rats, Sprague-Dawley; Testosterone; Treatment Outcome; Triazoles | 2011 |
Zoledronic acid inhibits aromatase activity and phosphorylation: potential mechanism for additive zoledronic acid and letrozole drug interaction.
Topics: Aromatase; Aromatase Inhibitors; Cell Survival; Diphosphonates; Drug Synergism; Estradiol; Female; Humans; Imidazoles; Letrozole; MCF-7 Cells; Microsomes; Nitriles; Phosphorylation; Pregnancy; RNA Stability; Serine; Triazoles; Zoledronic Acid | 2012 |
Rare case of ER positive colorectal stricture demonstrating improvement with letrozole.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Colorectal Neoplasms; Constriction, Pathologic; Female; Humans; Letrozole; Nitriles; Receptors, Estrogen; Triazoles | 2011 |
Breast cancer associated with an accessory nipple.
Topics: Aged, 80 and over; Aromatase Inhibitors; Biopsy, Large-Core Needle; Breast Neoplasms; Choristoma; Female; Humans; Letrozole; Nipples; Nitriles; Triazoles; Ultrasonography, Interventional; Ultrasonography, Mammary | 2011 |
Aromatase inhibition abolishes LTP generation in female but not in male mice.
Topics: Animals; Aromatase; Aromatase Inhibitors; Cells, Cultured; Cofilin 1; Dendritic Spines; Estradiol; Excitatory Postsynaptic Potentials; Female; Hippocampus; Letrozole; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Nitriles; Rats; Rats, Wistar; Sex Characteristics; Synapses; Triazoles | 2012 |
[A case of elderly locally-advanced breast cancer with skin ulcer responding to letrozole].
Topics: Aged, 80 and over; Antineoplastic Agents; Biopsy; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Humans; Letrozole; Neoplasm Grading; Neoplasm Staging; Nitriles; Skin Ulcer; Triazoles | 2012 |
Whole-genome analysis informs breast cancer response to aromatase inhibition.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast Neoplasms; DNA Repair; Exome; Exons; Female; Genetic Variation; Genome, Human; Humans; Letrozole; MAP Kinase Kinase 4; MAP Kinase Kinase Kinase 1; Mutation; Nitriles; Receptors, Estrogen; Treatment Outcome; Triazoles | 2012 |
Long-term survival in an untreated patient with leptomeningeal carcinomatosis from breast primary.
Topics: Antineoplastic Agents; Breast Neoplasms; Chronic Disease; Female; Humans; Hypesthesia; Immunohistochemistry; Letrozole; Magnetic Resonance Imaging; Meningeal Carcinomatosis; Middle Aged; Neural Conduction; Nitriles; Spinal Neoplasms; Survival; Triazoles | 2013 |
The pharmacokinetics of letrozole: association with key body mass metrics.
Topics: Adult; Aromatase Inhibitors; Aryl Hydrocarbon Hydroxylases; Body Composition; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP3A; Genotype; Humans; Letrozole; Male; Models, Biological; Nitriles; Polymorphism, Genetic; Triazoles | 2012 |
Safe chemotherapy and hormone therapy for treating early breast cancer in a glucose 6-phosphate dehydrogenase-deficient patient: case report.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Cyclophosphamide; Docetaxel; Drug Administration Schedule; Female; Glucosephosphate Dehydrogenase Deficiency; Humans; Letrozole; Middle Aged; Nitriles; Taxoids; Triazoles | 2012 |
Positron emission tomography with computed tomography (PET-CT) to evaluate the response of bone metastases to non-surgical treatment.
Topics: Aromatase Inhibitors; Bone Density Conservation Agents; Breast Neoplasms; Diphosphonates; Disease Progression; Female; Fluorodeoxyglucose F18; Humans; Ibandronic Acid; Letrozole; Magnetic Resonance Imaging; Middle Aged; Multimodal Imaging; Nitriles; Positron-Emission Tomography; Radiopharmaceuticals; Spinal Neoplasms; Tomography, X-Ray Computed; Triazoles | 2010 |
Synthesis and biological evaluation of two agents for imaging estrogen receptor β by positron emission tomography: challenges in PET imaging of a low abundance target.
Topics: Animals; Chemistry Techniques, Synthetic; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Letrozole; Ligands; Mice; Nitriles; Positron-Emission Tomography; Rats; Substrate Specificity; Triazoles | 2012 |
Does higher starting dose of FSH stimulation with letrozole improve fertility preservation outcomes in women with breast cancer?
Topics: Adult; Aromatase Inhibitors; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Therapy, Combination; Embryo Transfer; Female; Fertility Preservation; Follicle Stimulating Hormone, Human; Humans; Letrozole; Nitriles; Oocyte Retrieval; Pregnancy; Pregnancy Rate; Retrospective Studies; Triazoles | 2012 |
Effect of aromatase inhibitors on background parenchymal enhancement and amount of fibroglandular tissue at breast MR imaging.
Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Contrast Media; Female; Gadolinium DTPA; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Letrozole; Magnetic Resonance Imaging; Middle Aged; Neoplasm Staging; Nitriles; Postmenopause; Retrospective Studies; Subtraction Technique; Triazoles | 2012 |
Suppression of plasma estrogen levels by letrozole and anastrozole is related to body mass index in patients with breast cancer.
Topics: Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Body Mass Index; Breast Neoplasms; Estrogens; Estrone; Female; Humans; Letrozole; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Triazoles | 2012 |
Aromatase inhibition in obese women: how much is enough?
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Body Mass Index; Breast Neoplasms; Estrogens; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Triazoles | 2012 |
Successful combination: existing drugs boost cancer vaccine responses.
Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Cancer Vaccines; Daclizumab; Disease Models, Animal; Female; Humans; Immunoglobulin G; Letrozole; Lung Neoplasms; Membrane Glycoproteins; Mice; Nitriles; Treatment Outcome; Triazoles | 2012 |
Marked increase of final height by long-term aromatase inhibition in a boy with idiopathic short stature.
Topics: Adolescent; Aromatase; Aromatase Inhibitors; Body Height; Bone and Bones; Growth Disorders; Humans; Letrozole; Male; Nitriles; Radiography; Triazoles | 2012 |
The importance of HER2 signaling in the tumor-initiating cell population in aromatase inhibitor-resistant breast cancer.
Topics: Animals; Aromatase Inhibitors; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; ErbB Receptors; Female; Humans; Letrozole; MCF-7 Cells; Mice; Mice, Nude; Neoplasm Proteins; Neoplastic Stem Cells; Nitriles; Receptor, ErbB-2; Signal Transduction; Triazoles; Xenograft Model Antitumor Assays | 2012 |
Discordant cellular response to presurgical letrozole in bilateral synchronous ER+ breast cancers with a KRAS mutation or FGFR1 gene amplification.
Topics: Aromatase Inhibitors; Base Sequence; Breast Neoplasms; Drug Resistance, Neoplasm; Female; Gene Amplification; Humans; Letrozole; Middle Aged; Molecular Sequence Data; Mutation; Nitriles; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Estrogen; Triazoles | 2012 |
Macular oedema due to letrozole: a first case report.
Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Diagnosis, Differential; Female; Fluorescein Angiography; Fundus Oculi; Humans; Letrozole; Macular Edema; Nitriles; Tomography, Optical Coherence; Triazoles | 2012 |
[Endobronchial metastases from breast cancer: a clinicopathological and survival analysis].
Topics: Adult; Antineoplastic Agents; Breast Neoplasms; Bronchial Neoplasms; Carcinoma, Ductal, Breast; Chemotherapy, Adjuvant; Female; Follow-Up Studies; Humans; Letrozole; Lymphatic Metastasis; Mastectomy, Modified Radical; Middle Aged; Nitriles; Radiotherapy, Adjuvant; Retrospective Studies; Survival Analysis; Triazoles | 2012 |
Efficacy and mechanism of action of Proellex, an antiprogestin in aromatase overexpressing and Letrozole resistant T47D breast cancer cells.
Topics: Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Base Sequence; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Female; Gene Expression; Genes, erbB-1; Humans; Letrozole; Nitriles; Norpregnadienes; Progestins; Promegestone; Receptors, Progesterone; RNA, Messenger; RNA, Neoplasm; Tamoxifen; Testosterone; Triazoles; Tumor Stem Cell Assay | 2013 |
Comparison of the effects of aromatase inhibitors and tamoxifen on radiation-induced lung toxicity: results of an experimental study.
Topics: Anastrozole; Animals; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Combined Modality Therapy; Female; Letrozole; Nitriles; Pulmonary Fibrosis; Radiation Injuries, Experimental; Rats; Rats, Wistar; Statistics, Nonparametric; Tamoxifen; Triazoles | 2013 |
Dry eye syndrome in aromatase inhibitor users.
Topics: Aged; Aged, 80 and over; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Blepharitis; Breast Neoplasms; Conjunctival Diseases; Dry Eye Syndromes; Female; Humans; Keratitis; Letrozole; Middle Aged; Nitriles; Ovarian Neoplasms; Retrospective Studies; Triazoles; Vision Disorders | 2013 |
Co-expression of estrogen receptor beta and aromatase in Japanese lung cancer patients: gender-dependent clinical outcome.
Topics: Aged; Androgens; Aromatase; Aromatase Inhibitors; Asian People; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Estrogen Receptor beta; Estrogens; Female; Gene Expression Regulation, Neoplastic; Humans; Letrozole; Lung; Lung Neoplasms; Male; Middle Aged; Nitriles; Sex Factors; Testosterone; Treatment Outcome; Triazoles | 2012 |
New ruthenium(II)-letrozole complexes as anticancer therapeutics.
Topics: Adenine; Adenocarcinoma; Antineoplastic Agents; Aromatase Inhibitors; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Coordination Complexes; Crystallography, X-Ray; Curcumin; Drug Interactions; Drug Screening Assays, Antitumor; Female; Glioblastoma; Humans; Letrozole; Nitriles; Ruthenium; Stereoisomerism; Structure-Activity Relationship; Triazoles | 2012 |
Re: Effect of letrozole on uterine artery Doppler flow indices prior to first-trimester termination of pregnancy: a randomized controlled trial. V. C. Y. Lee, T. W. Y. Yeung, O. S. Tang, E. H. Y. Ng, W. S. B. Yeung and P. C. Ho. Ultrasound Obstet Gynecol
Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Female; Humans; Letrozole; Nitriles; Pregnancy; Pulsatile Flow; Triazoles; Ultrasonography; Uterine Artery; Uterine Hemorrhage | 2012 |
Role for endogenous estrogen in prepubertal Sertoli cell maturation.
Topics: Animals; Anti-Mullerian Hormone; Aromatase; Aromatase Inhibitors; Blotting, Western; Cyclin-Dependent Kinase Inhibitor p27; Estrogens; Immunohistochemistry; Letrozole; Male; Nitriles; Sertoli Cells; Swine; Testis; Triazoles | 2012 |
Testosterone/estradiol ratio regulates NO-induced bladder relaxation and responsiveness to PDE5 inhibitors.
Topics: Androgens; Animals; Aromatase Inhibitors; Cyclic Nucleotide Phosphodiesterases, Type 5; Estradiol; Estrogens; Female; Gene Expression; Imidazoles; Letrozole; Male; Muscle Relaxation; Muscle, Smooth; Nitric Oxide Donors; Nitriles; Nitroprusside; Ovariectomy; Phosphodiesterase 5 Inhibitors; Piperazines; Progesterone; Progestins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sex Factors; Sulfones; Testosterone; Triazines; Triazoles; Urinary Bladder; Vardenafil Dihydrochloride | 2012 |
Introduction of modern endocrine techniques for the production of monosex population of fishes.
Topics: Animals; Aromatase Inhibitors; Estradiol; Female; Fishes; Letrozole; Male; Methyltestosterone; Nitriles; Sex Differentiation; Tamoxifen; Tilapia; Triazoles | 2013 |
Effectiveness and molecular interactions of the clinically active mTORC1 inhibitor everolimus in combination with tamoxifen or letrozole in vitro and in vivo.
Topics: Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Nucleolus; Cell Proliferation; Disease Models, Animal; Drug Resistance, Neoplasm; Everolimus; Female; Humans; Letrozole; Mechanistic Target of Rapamycin Complex 1; Mice; Multiprotein Complexes; Nitriles; Phosphorylation; Protein Kinase Inhibitors; Protein Transport; Proto-Oncogene Proteins c-akt; Receptor, ErbB-3; Receptors, Estrogen; Signal Transduction; Sirolimus; Tamoxifen; TOR Serine-Threonine Kinases; Triazoles; Xenograft Model Antitumor Assays | 2012 |
The chondroprotective effects of dehydroepiandrosterone probably exerted by its conversion to estradiol.
Topics: Adjuvants, Immunologic; Animals; Aromatase Inhibitors; Cartilage; Cells, Cultured; Chondrocytes; Dehydroepiandrosterone; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Gene Expression Regulation; Letrozole; Matrix Metalloproteinase 13; Matrix Metalloproteinase 3; Nitriles; Osteoarthritis; Rabbits; Tissue Inhibitor of Metalloproteinase-1; Triazoles | 2013 |
Efficacy of adjuvant aromatase inhibitor in hormone receptor-positive postmenopausal breast cancer patients according to the body mass index.
Topics: Aged; Anastrozole; Aromatase Inhibitors; Body Mass Index; Breast Neoplasms; Disease-Free Survival; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Retrospective Studies; Triazoles | 2012 |
Plasma estrone sulfate concentrations and genetic variation at the CYP19A1 locus in postmenopausal women with early breast cancer treated with letrozole.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Estrone; Female; Genetic Association Studies; Genotype; Humans; Letrozole; Middle Aged; Nitriles; Polymorphism, Single Nucleotide; Postmenopause; Prospective Studies; Triazoles | 2013 |
Aromatase inhibitors associated with knee subchondral bone expansion without cartilage loss.
Topics: Anastrozole; Aromatase Inhibitors; Breast Neoplasms; Case-Control Studies; Female; Humans; Letrozole; Magnetic Resonance Imaging; Menisci, Tibial; Middle Aged; Nitriles; Postmenopause; Prospective Studies; Tibia; Triazoles | 2013 |
Budget impact analysis of everolimus for the treatment of hormone receptor positive, human epidermal growth factor receptor-2 negative (HER2-) advanced breast cancer in the United States.
Topics: Anastrozole; Antineoplastic Agents; Breast Neoplasms; Budgets; Cost-Benefit Analysis; Drug Costs; ErbB Receptors; Everolimus; Female; Health Care Costs; Humans; Letrozole; Middle Aged; Nitriles; Receptor, ErbB-2; Severity of Illness Index; Sirolimus; Treatment Failure; Triazoles; United States | 2013 |
Inhibition of the proliferation of acquired aromatase inhibitor-resistant breast cancer cells by histone deacetylase inhibitor LBH589 (panobinostat).
Topics: Aged; Androstadienes; Animals; Antineoplastic Agents; Apoptosis; Aromatase Inhibitors; Breast Neoplasms; Cell Cycle Checkpoints; Cell Proliferation; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Gene Expression; Gene Knockdown Techniques; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Indoles; Letrozole; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; NF-kappa B p50 Subunit; Nitriles; Panobinostat; Triazoles; Tumor Burden; Xenograft Model Antitumor Assays | 2013 |
Increased testicular Sertoli cell population induced by an estrogen receptor antagonist.
Topics: Animals; Aromatase; Cell Count; Estradiol; Estrogen Antagonists; Fulvestrant; Letrozole; Male; Nitriles; Pituitary Hormones; Receptors, Estrogen; Sertoli Cells; Steroids; Sus scrofa; Triazoles | 2013 |
Aromatase overexpression induces malignant changes in estrogen receptor α negative MCF-10A cells.
Topics: Androstenedione; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; CD24 Antigen; Cell Line; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Estradiol; Estrogen Receptor alpha; Female; Gene Expression; Humans; Hyaluronan Receptors; Letrozole; Neoplastic Stem Cells; Nitriles; RNA, Messenger; Spheroids, Cellular; Triazoles | 2013 |
Letrozole: advancing hormone therapy in breast cancer.
Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Female; Humans; Letrozole; Neoplasm Staging; Nitriles; Postmenopause; Quality of Life; Tamoxifen; Triazoles | 2012 |
Continuous administration of a P450 aromatase inhibitor induces polycystic ovary syndrome with a metabolic and endocrine phenotype in female rats at adult age.
Topics: Animals; Aromatase Inhibitors; Female; Letrozole; Nitriles; Polycystic Ovary Syndrome; Rats; Rats, Wistar; Triazoles | 2013 |
Letrozole increases ovarian growth and Cyp17a1 gene expression in the rat ovary.
Topics: Animals; Aromatase Inhibitors; Bacterial Proteins; Body Weight; Cell Proliferation; Cells, Cultured; Coculture Techniques; Estrous Cycle; Female; Gene Expression; Granulosa Cells; Hormones; Letrozole; Nitriles; Organ Size; Ovary; Rats; Repressor Proteins; RNA, Messenger; Steroid 17-alpha-Hydroxylase; Theca Cells; Triazoles | 2013 |
The citrus flavonone hesperetin prevents letrozole-induced bone loss in a mouse model of breast cancer.
Topics: Animals; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Citrus; Estradiol; Female; Hesperidin; Humans; Letrozole; MCF-7 Cells; Mice; Mice, Nude; Nitriles; Osteoporosis; Selective Estrogen Receptor Modulators; Triazoles; Xenograft Model Antitumor Assays | 2013 |
Aromatase inhibitor treatment limits progression of peritoneal endometriosis in baboons.
Topics: Animals; Aromatase; Aromatase Inhibitors; Disease Models, Animal; Disease Progression; Endometriosis; Female; Laparoscopy; Letrozole; Menstruation; Nitriles; Organ Size; Ovary; Papio anubis; Peritoneum; RNA, Messenger; Treatment Outcome; Triazoles | 2013 |
Uterine metastasis of lobular breast cancer during adjuvant letrozole therapy.
Topics: Antigens, Tumor-Associated, Carbohydrate; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Lobular; Carrier Proteins; Chemotherapy, Adjuvant; Fatal Outcome; Female; Glycoproteins; Humans; Letrozole; Membrane Transport Proteins; Middle Aged; Nitriles; Triazoles; Uterine Neoplasms | 2013 |
Rapid determination of letrozole, citalopram and their metabolites by high performance liquid chromatography-fluorescence detection in urine: Method validation and application to real samples.
Topics: Antidepressive Agents, Second-Generation; Antineoplastic Agents; Breast Neoplasms; Chromatography, High Pressure Liquid; Citalopram; Depression; Drug Monitoring; Female; Humans; Letrozole; Limit of Detection; Middle Aged; Nitriles; Reproducibility of Results; Spectrometry, Fluorescence; Triazoles | 2013 |
[A case of advanced breast carcinoma treated with topical S-1 plus letrozole].
Topics: Antineoplastic Combined Chemotherapy Protocols; Biopsy; Breast Neoplasms; Drug Combinations; Female; Humans; Letrozole; Middle Aged; Neoplasm Staging; Nitriles; Oxonic Acid; Tegafur; Treatment Outcome; Triazoles | 2012 |
[Clinical effect of letrozole on the ovulation induction in endometrial preparation for frozen-thawed embryo transfer].
Topics: Case-Control Studies; Cryopreservation; Embryo Transfer; Endometrium; Female; Fertility Agents, Female; Fertilization in Vitro; Humans; Letrozole; Nitriles; Ovulation Induction; Triazoles | 2012 |
Acute cerebrovascular accident after cisplatin treatment in a patient taking letrozole.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Female; Hemianopsia; Humans; Letrozole; Lung Neoplasms; Middle Aged; Nitriles; Stroke; Triazoles | 2012 |
Frozen embryo transfer: the present practice and beyond.
Topics: Adult; Cryopreservation; Embryo Implantation; Embryo Transfer; Endometrium; Enzyme Inhibitors; Female; Fertilization in Vitro; Freezing; Hormone Replacement Therapy; Hormones; Humans; Letrozole; Menstrual Cycle; Nitriles; Ovarian Hyperstimulation Syndrome; Ovulation; Ovulation Induction; Pregnancy; Pregnancy Rate; Triazoles | 2013 |
What is the optimal endocrine therapy for postmenopausal women with hormone receptor-positive early breast cancer?
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Practice Guidelines as Topic; Receptors, Estrogen; Tamoxifen; Time Factors; Triazoles | 2013 |
Therapeutic mammaplasty--extending indications and achieving low incomplete excision rates.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Female; Humans; Letrozole; Mammaplasty; Mastectomy, Segmental; Middle Aged; Neoadjuvant Therapy; Neoplasm, Residual; Nitriles; Patient Satisfaction; Retrospective Studies; Treatment Outcome; Triazoles | 2013 |
The aromatase inhibitor letrozole reduces adhesion formation after intraperitoneal surgery in a rat uterine horn model.
Topics: Animals; Aromatase Inhibitors; Female; Foreign-Body Reaction; Letrozole; Nitriles; Peritoneal Cavity; Peritoneum; Postoperative Period; Preoperative Period; Random Allocation; Rats; Rats, Wistar; Selective Estrogen Receptor Modulators; Tamoxifen; Tissue Adhesions; Triazoles; Uterus | 2013 |
18F-fluoromisonidazole PET/CT: a potential tool for predicting primary endocrine therapy resistance in breast cancer.
Topics: Aged; Aged, 80 and over; Aromatase Inhibitors; Breast Neoplasms; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Ki-67 Antigen; Letrozole; Middle Aged; Misonidazole; Multimodal Imaging; Neoplasms, Hormone-Dependent; Nitriles; Positron-Emission Tomography; Radiopharmaceuticals; Tomography, X-Ray Computed; Triazoles | 2013 |
[Effect of letrozole on endometrosis and apoptosis of ectopic endometrial cells in rats].
Topics: Animals; Apoptosis; Aromatase; Aromatase Inhibitors; bcl-2-Associated X Protein; Cyclooxygenase 2; Endometriosis; Endometrium; Female; Letrozole; Nitriles; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Triazoles | 2013 |
Response to ovarian stimulation in patients facing gonadotoxic therapy.
Topics: Adult; Antineoplastic Agents; Female; Fertility Preservation; Fertilization in Vitro; Gonadotropins; Humans; Letrozole; Neoplasms; Nitriles; Oocyte Retrieval; Ovary; Ovulation Induction; Triazoles | 2013 |
Should all postmenopausal patients with hormone receptor-positive breast cancer receive initial therapy with aromatase inhibitors?
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Letrozole; Nitriles; Postmenopause; Receptors, Estrogen; Tamoxifen; Time Factors; Treatment Outcome; Triazoles | 2013 |
Does zoledronic acid have additive effect on suppression of plasma estrogen levels?
Topics: Aromatase Inhibitors; Bone Density Conservation Agents; Breast Neoplasms; Diphosphonates; Drug Synergism; Estrogens; Female; Humans; Imidazoles; Letrozole; Nitriles; Triazoles; Zoledronic Acid | 2013 |
Effect of aromatase inhibitors on bone mineral density in a Japanese breast cancer population.
Topics: Aged; Aged, 80 and over; Anastrozole; Androstadienes; Aromatase Inhibitors; Asian People; Bone Density; Breast Neoplasms; Diphosphonates; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Retrospective Studies; Triazoles | 2013 |
GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors.
Topics: Aromatase Inhibitors; Blotting, Western; Breast Neoplasms; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Cohort Studies; Drug Resistance, Neoplasm; Estradiol; Estrogen Receptor alpha; Female; Fulvestrant; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glial Cell Line-Derived Neurotrophic Factor; Humans; Kaplan-Meier Estimate; Letrozole; MCF-7 Cells; Middle Aged; Nitriles; Oligonucleotide Array Sequence Analysis; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-ret; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Triazoles | 2013 |
Evaluation of the possible protective role of quercetin on letrozole-induced testicular injury in male albino rats.
Topics: Animals; Aromatase Inhibitors; Biomarkers; Cytoprotection; Dose-Response Relationship, Drug; Estradiol; Follicle Stimulating Hormone; Letrozole; Luteinizing Hormone; Male; Nitriles; Protective Agents; Quercetin; Rats; Rats, Wistar; Sertoli Cells; Spermatozoa; Testis; Testosterone; Time Factors; Triazoles | 2013 |
Optimal combination of radiotherapy and endocrine drugs in breast cancer treatment.
Topics: Antineoplastic Agents, Hormonal; Apoptosis; Aromatase Inhibitors; bcl-2-Associated X Protein; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Down-Regulation; Female; Humans; Letrozole; Nitriles; Proto-Oncogene Proteins c-bcl-2; Radiotherapy Dosage; Tamoxifen; Triazoles; Up-Regulation | 2013 |
Effects of methyltestosterone, letrozole, triphenyltin and fenarimol on histology of reproductive organs of the copepod Acartia tonsa.
Topics: Androgens; Animals; Copepoda; Endocrine Disruptors; Female; Gonads; Letrozole; Male; Methyltestosterone; Nitriles; Organotin Compounds; Pyrimidines; Triazoles | 2013 |
Anti-Ri antibody-associated paraneoplastic brainstem encephalitis successfully treated after treating the underlying malignancy with letrozole.
Topics: Aged, 80 and over; Antibodies, Anti-Idiotypic; Antineoplastic Agents; Brain Stem Neoplasms; Breast Neoplasms; Encephalitis; Female; Humans; Letrozole; Nitriles; Treatment Outcome; Triazoles | 2013 |
5α-reductase inhibition suppresses testosterone-induced initial regrowth of regressed xenograft prostate tumors in animal models.
Topics: 5-alpha Reductase Inhibitors; Animals; Azasteroids; Cell Line, Tumor; Cell Proliferation; Dutasteride; Finasteride; Humans; Immunohistochemistry; Letrozole; Male; Mice; Mice, Nude; Mice, SCID; Nitriles; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Testosterone; Triazoles | 2013 |
Cutaneous leukocytoclastic vasculitis associated with letrozole.
Topics: Aged; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Triazoles; Vasculitis, Leukocytoclastic, Cutaneous | 2014 |
Proteomic signatures of acquired letrozole resistance in breast cancer: suppressed estrogen signaling and increased cell motility and invasiveness.
Topics: Actin Cytoskeleton; Amides; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Shape; Drug Resistance, Neoplasm; Estrogens; Female; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Letrozole; Mesoderm; Neoplasm Invasiveness; Neoplasm Proteins; Nitriles; Protein Kinase Inhibitors; Proteomics; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Triazoles; Vimentin | 2013 |
Investigation of the effect of active efflux at the blood-brain barrier on the distribution of nonsteroidal aromatase inhibitors in the central nervous system.
Topics: Anastrozole; Animals; Aromatase; Aromatase Inhibitors; ATP Binding Cassette Transporter, Subfamily B; Blood-Brain Barrier; Brain; Cell Line; Humans; Letrozole; Male; Mice; Nitriles; Triazoles | 2013 |
The pharmacokinetics of letrozole in brain and brain tumor in rats with orthotopically implanted C6 glioma, assessed using intracerebral microdialysis.
Topics: Algorithms; Animals; Antineoplastic Agents; Area Under Curve; Brain; Brain Neoplasms; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Extracellular Fluid; Female; Glioma; Humans; Letrozole; Microdialysis; Neoplasm Transplantation; Nitriles; Protein Binding; Rats; Rats, Sprague-Dawley; Triazoles | 2013 |
Intratumoral concentration of estrogens and clinicopathological changes in ductal carcinoma in situ following aromatase inhibitor letrozole treatment.
Topics: Aged; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Estrogens; Female; Humans; Ki-67 Antigen; Letrozole; Middle Aged; Nitriles; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Triazoles | 2013 |
Tamoxifen therapy for patients with breast cancer.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Disease-Free Survival; Female; Humans; Letrozole; Nitriles; Postmenopause; Premenopause; Risk Factors; Tamoxifen; Time Factors; Treatment Outcome; Triazoles | 2013 |
Tamoxifen therapy for patients with breast cancer - Authors' reply.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles | 2013 |
Androgen metabolite-dependent growth of hormone receptor-positive breast cancer as a possible aromatase inhibitor-resistance mechanism.
Topics: Androgens; Androstane-3,17-diol; Aromatase Inhibitors; Breast Neoplasms; Dihydrotestosterone; Drug Resistance, Neoplasm; Female; Green Fluorescent Proteins; Humans; Letrozole; MCF-7 Cells; Multienzyme Complexes; Nitriles; Progesterone Reductase; Receptors, Androgen; Receptors, Estrogen; Response Elements; Signal Transduction; Steroid Isomerases; Testosterone; Triazoles | 2013 |
Effects of femara and tamoxifen on proliferation of FM3A cells in culture.
Topics: Animals; Antineoplastic Agents; Apoptosis; Aromatase Inhibitors; Cell Line, Tumor; Cell Proliferation; Estrogen Antagonists; Female; Letrozole; Mammary Neoplasms, Animal; Mice; Mice, Inbred C3H; Mitotic Index; Nitriles; Receptors, Estrogen; Tamoxifen; Triazoles | 2013 |
Successful use of aromatase inhibitor letrozole in NOA with an elevated FSH level: a case report.
Topics: Adult; Aromatase Inhibitors; Follicle Stimulating Hormone; Humans; Infertility, Male; Letrozole; Male; Nitriles; Oligospermia; Spermatogenesis; Triazoles | 2014 |
Letrozole stimulation in endometrial preparation for cryopreserved-thawed embryo transfer in women with polycystic ovarian syndrome: a pilot study.
Topics: Adult; Aromatase Inhibitors; Cryopreservation; Embryo Transfer; Endometrium; Female; Fertilization in Vitro; Humans; Letrozole; Male; Nitriles; Pilot Projects; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Retrospective Studies; Triazoles | 2014 |
Prediction of late disease recurrence and extended adjuvant letrozole benefit by the HOXB13/IL17BR biomarker.
Topics: Adult; Aged; Antineoplastic Agents; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Case-Control Studies; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Homeodomain Proteins; Humans; Incidence; Letrozole; Logistic Models; Middle Aged; Multivariate Analysis; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasm Staging; Nitriles; Predictive Value of Tests; Prognosis; Prospective Studies; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Interleukin; Receptors, Interleukin-17; Receptors, Progesterone; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; Triazoles | 2013 |
Key genes for modulating information flow play a temporal role as breast tumor coexpression networks are dynamically rewired by letrozole.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Computational Biology; Female; Gene Expression Profiling; Gene Regulatory Networks; Humans; Letrozole; Nitriles; Oligonucleotide Array Sequence Analysis; Time Factors; Triazoles | 2013 |
A UK national survey of breast surgeons on primary endocrine therapy of early operable breast cancer.
Topics: Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Female; General Surgery; Health Surveys; Humans; Letrozole; Nitriles; Practice Patterns, Physicians'; Tamoxifen; Triazoles | 2013 |
Predictive factors for pregnancy during the first four intrauterine insemination cycles using gonadotropin.
Topics: Adult; Clomiphene; Female; Fertility Agents, Female; Gonadotropins; Humans; Infertility, Female; Insemination, Artificial; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Prognosis; Retrospective Studies; Triazoles | 2013 |
The case for aromatase inhibitors use in oncofertility patients. Should aromatase inhibitors be combined with gonadotropin treatment in breast cancer patients undergoing ovarian stimulation for fertility preservation prior to chemotherapy? A debate.
Topics: Animals; Aromatase Inhibitors; Breast Neoplasms; Cryopreservation; Estradiol; Female; Fertility Preservation; Fertilization in Vitro; Follicle Stimulating Hormone; Humans; Letrozole; Mice; Nitriles; Oocytes; Ovulation Induction; Tissue and Organ Harvesting; Triazoles | 2013 |
The letrozole phase 1 metabolite carbinol as a novel probe drug for UGT2B7.
Topics: Glucuronosyltransferase; Humans; Kinetics; Letrozole; Liver; Metabolic Detoxication, Phase I; Methanol; Microsomes, Liver; Nitriles; Polymorphism, Genetic; Recombinant Proteins; Triazoles | 2013 |
Letrozole combined with gonadotropin-releasing hormone analog for metastatic male breast cancer.
Topics: Aged; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms, Male; Carcinoma, Ductal, Breast; Carcinoma, Papillary; Chemotherapy, Adjuvant; Combined Modality Therapy; Cyclophosphamide; Disease-Free Survival; Docetaxel; Epirubicin; Estrogen Receptor Modulators; Estrogens; Fluorouracil; Gonadotropin-Releasing Hormone; Goserelin; Humans; Kaplan-Meier Estimate; Letrozole; Male; Mastectomy, Modified Radical; Methotrexate; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Progesterone; Radiotherapy, Adjuvant; Tamoxifen; Taxoids; Triazoles | 2013 |
Is letrozole needed for controlled ovarian stimulation in patients with estrogen receptor-positive breast cancer?
Topics: Adult; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Cohort Studies; Cryopreservation; Estradiol; Female; Fertility Preservation; Gonadotropins; Humans; Italy; Letrozole; Neoplasm Proteins; Nitriles; Oocyte Retrieval; Oocytes; Oogenesis; Ovulation Induction; Receptors, Estrogen; Retrospective Studies; Triazoles; Up-Regulation | 2013 |
Impact of body mass index on estradiol depletion by aromatase inhibitors in postmenopausal women with early breast cancer.
Topics: Aged; Aged, 80 and over; Anastrozole; Aromatase Inhibitors; Body Mass Index; Breast Neoplasms; Estradiol; Female; Humans; Letrozole; Middle Aged; Nitriles; Obesity; Postmenopause; Prospective Studies; Receptors, Estrogen; Survival Analysis; Triazoles | 2013 |
QSAR modeling of aromatase inhibitory activity of 1-substituted 1,2,3-triazole analogs of letrozole.
Topics: Aromatase; Aromatase Inhibitors; Dose-Response Relationship, Drug; Humans; Letrozole; Linear Models; Models, Molecular; Molecular Structure; Neural Networks, Computer; Nitriles; Quantitative Structure-Activity Relationship; Structure-Activity Relationship; Triazoles | 2013 |
Everolimus in combination with letrozole inhibit human breast cancer MCF-7/Aro stem cells via PI3K/mTOR pathway: an experimental study.
Topics: Animals; Apoptosis; Aromatase; Breast Neoplasms; Cell Proliferation; Drug Synergism; Elafin; Everolimus; Female; Gene Expression Regulation, Neoplastic; Humans; Letrozole; MCF-7 Cells; Mice; Nitriles; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Triazoles; Xenograft Model Antitumor Assays | 2014 |
Letrozole efficacy in the treatment of granulosa cell tumor of the ovary: a case report.
Topics: Antineoplastic Agents; Female; Granulosa Cell Tumor; Humans; Letrozole; Middle Aged; Nitriles; Ovarian Neoplasms; Radiography; Treatment Outcome; Triazoles | 2013 |
Safety and feasibility of performing two consecutive ovarian stimulation cycles with the use of letrozole-gonadotropin protocol for fertility preservation in breast cancer patients.
Topics: Adult; Breast Neoplasms; Cohort Studies; Comorbidity; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Feasibility Studies; Female; Fertility Agents; Fertility Preservation; Gonadotropins; Humans; Infertility, Female; Letrozole; New York; Nitriles; Ovulation Induction; Prevalence; Retrospective Studies; Risk Factors; Treatment Outcome; Triazoles | 2013 |
Inhibition of ubiquitin conjugating enzyme UBE2C reduces proliferation and sensitizes breast cancer cells to radiation, doxorubicin, tamoxifen and letrozole.
Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Doxorubicin; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; HEK293 Cells; Humans; Letrozole; MCF-7 Cells; Nitriles; Reverse Transcriptase Polymerase Chain Reaction; Tamoxifen; Triazoles; Ubiquitin-Conjugating Enzymes | 2013 |
Estradiol responsiveness of synaptopodin in hippocampal neurons is mediated by estrogen receptor β.
Topics: Animals; Aromatase; Cells, Cultured; Estradiol; Estrogen Receptor beta; Hippocampus; Immunohistochemistry; Letrozole; Mice; Mice, Knockout; Microfilament Proteins; Neurons; Nitriles; Rats; Triazoles | 2013 |
Effects of non-steroidal aromatase inhibitor letrozole on sex inversion and spermatogenesis in yellow catfish Pelteobagrus fulvidraco.
Topics: Animals; Aromatase Inhibitors; Catfishes; Female; Gonads; Letrozole; Male; Nitriles; Phenotype; Sex Characteristics; Sex Determination Processes; Sex Ratio; Triazoles | 2013 |
Aromatase inhibitor treatment with an intravaginal device and its effect on pre-ovulatory ovarian follicles in a bovine model.
Topics: Administration, Intravaginal; Animals; Aromatase Inhibitors; Cattle; Corpus Luteum; Estradiol; Estrus Synchronization; Female; Letrozole; Nitriles; Ovarian Follicle; Ovulation Inhibition; Progesterone; Time Factors; Triazoles | 2013 |
HDAC inhibitor entinostat restores responsiveness of letrozole-resistant MCF-7Ca xenografts to aromatase inhibitors through modulation of Her-2.
Topics: Animals; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Benzamides; Disease Models, Animal; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; HSP90 Heat-Shock Proteins; Humans; Letrozole; MAP Kinase Signaling System; MCF-7 Cells; Mice; Nitriles; Pyridines; Receptor, ErbB-2; RNA Stability; Triazoles; Tumor Burden; Xenograft Model Antitumor Assays | 2013 |
Role of the aromatase inhibitor letrozole in the management of uterine leiomyomas in premenopausal women.
Topics: Adult; Aromatase Inhibitors; Female; Humans; Leiomyoma; Letrozole; Middle Aged; Nitriles; Premenopause; Prospective Studies; Triazoles; Uterine Neoplasms | 2013 |
An assessment of current clinical attitudes toward letrozole use in reproductive endocrinology practices.
Topics: Aromatase Inhibitors; Attitude of Health Personnel; Attitude to Health; Comorbidity; Drug-Related Side Effects and Adverse Reactions; Endocrinology; Female; Health Care Surveys; Health Knowledge, Attitudes, Practice; Humans; Infertility, Female; Letrozole; Nitriles; Off-Label Use; Ovulation Induction; Physicians; Practice Patterns, Physicians'; Prevalence; Reproductive Medicine; Risk Assessment; Triazoles; United States | 2013 |
[Establishment of an aromatase inhibitor letrozole-resistant breast cancer cell model].
Topics: Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Cell Proliferation; Drug Resistance, Neoplasm; Humans; Letrozole; MCF-7 Cells; Models, Biological; Nitriles; Triazoles | 2013 |
Regulation of baboon fetal ovarian development by placental estrogen: onset of puberty is delayed in offspring deprived of estrogen in utero.
Topics: Animals; Estradiol; Estrogens; Female; Fetal Development; Fetus; Letrozole; Models, Animal; Nitriles; Ovary; Papio; Placenta; Pregnancy; Prenatal Exposure Delayed Effects; Puberty; Sexual Maturation; Triazoles | 2013 |
A pilot study on the combined use of letrozole, mifepristone and misoprostol in termination of first trimester pregnancy up to 9 weeks' gestation.
Topics: Abortifacient Agents, Nonsteroidal; Abortifacient Agents, Steroidal; Abortion, Induced; Adult; Aromatase Inhibitors; Female; Humans; Letrozole; Mifepristone; Misoprostol; Nitriles; Pilot Projects; Pregnancy; Triazoles | 2013 |
Extra virgin olive oil potentiates the effects of aromatase inhibitors via glutathione depletion in estrogen receptor-positive human breast cancer (MCF-7) cells.
Topics: Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Aromatase Inhibitors; Cytochromes c; Female; Glutathione; Humans; Letrozole; MCF-7 Cells; Nitriles; Oleic Acid; Olive Oil; Plant Oils; Reactive Oxygen Species; Receptors, Estrogen; Triazoles | 2013 |
Effect of vehicle and route of administration of letrozole on ovarian function in a bovine model.
Topics: Animals; Benzyl Alcohol; Biomarkers; Cattle; Chemistry, Pharmaceutical; Corpus Luteum; Estradiol; Estrus Synchronization; Feasibility Studies; Female; Fertility Agents, Female; Injections, Intramuscular; Injections, Intravenous; Letrozole; Luteinizing Hormone; Models, Animal; Nitriles; Ovarian Follicle; Ovary; Pharmaceutical Vehicles; Progesterone; Sesame Oil; Time Factors; Triazoles; Ultrasonography | 2014 |
Quantitative ER and PgR assessment as predictors of benefit from lapatinib in postmenopausal women with hormone receptor-positive, HER2-negative metastatic breast cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Disease-Free Survival; Female; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Kaplan-Meier Estimate; Lapatinib; Letrozole; Middle Aged; Neoplasm Metastasis; Nitriles; Postmenopause; Quinazolines; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Retrospective Studies; Triazoles | 2014 |
Synthesis and characterization of poly[1-(N,N-bis-carboxymethyl)amino-3-allylglycerol-co-dimethylacrylamide] grafted to magnetic nano-particles for extraction and determination of letrozole in biological and pharmaceutical samples.
Topics: Acrylic Resins; Adsorption; Antineoplastic Agents; Binding Sites; Drug Carriers; Female; Humans; Hydrogen-Ion Concentration; Kinetics; Letrozole; Magnetite Nanoparticles; Microscopy, Electron, Scanning; Nitriles; Organosilicon Compounds; Porosity; Silanes; Solid Phase Extraction; Spectroscopy, Fourier Transform Infrared; Thermogravimetry; Triazoles | 2013 |
Expression of estrogen-related gene markers in breast cancer tissue predicts aromatase inhibitor responsiveness.
Topics: 3-Hydroxysteroid Dehydrogenases; Aldo-Keto Reductase Family 1 Member C3; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Biomarkers, Tumor; BRCA1 Protein; Breast Neoplasms; Chemotherapy, Adjuvant; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Estrogens; Female; Gene Expression Regulation, Neoplastic; Genetic Markers; Humans; Hydroxyprostaglandin Dehydrogenases; Letrozole; Middle Aged; Nitriles; Receptors, Progesterone; ROC Curve; Tamoxifen; Treatment Outcome; Triazoles | 2013 |
Fertility preservation with ovarian stimulation protocols prior to cancer treatment.
Topics: Aromatase Inhibitors; Estrogen Antagonists; Female; Fertility Preservation; Gonadotropins; Humans; Letrozole; Neoplasms; Neoplasms, Hormone-Dependent; Nitriles; Ovulation Induction; Precision Medicine; Tamoxifen; Time-to-Treatment; Triazoles | 2014 |
Effects of electro-acupuncture on ovarian P450arom, P450c17α and mRNA expression induced by letrozole in PCOS rats.
Topics: Acupuncture Therapy; Animals; Aromatase; Female; Immunohistochemistry; Letrozole; Microscopy, Electron, Transmission; Nitriles; Ovary; Polycystic Ovary Syndrome; Rats; Rats, Sprague-Dawley; RNA, Messenger; Steroid 17-alpha-Hydroxylase; Triazoles | 2013 |
Expression of the c-Kit receptor in germ cells of the seminiferous epithelium in rats with hormonal imbalance.
Topics: Animals; Body Weights and Measures; Germ Cells; Immunohistochemistry; Isoflavones; Letrozole; Male; Nitriles; Proto-Oncogene Proteins c-kit; Rats; Rats, Wistar; Seminiferous Epithelium; Statistics, Nonparametric; Testis; Testosterone; Triazoles | 2013 |
Ejaculatory sperm production in non-obstructive azoospermic patients with a history of negative testicular biopsy after the administration of an aromatase inhibitor: report of two cases.
Topics: Adult; Aromatase Inhibitors; Azoospermia; Ejaculation; Humans; Letrozole; Male; Nitriles; Sperm Motility; Spermatogenesis; Treatment Outcome; Triazoles | 2014 |
Endometrial receptivity markers in infertile women stimulated with letrozole compared with clomiphene citrate and natural cycles.
Topics: Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Infertility, Male; Letrozole; Male; Nitriles; Triazoles | 2014 |
Neuroestradiol in the hypothalamus contributes to the regulation of gonadotropin releasing hormone release.
Topics: Animals; Aromatase Inhibitors; Chromatography, High Pressure Liquid; Electric Stimulation; Electrodes, Implanted; Estradiol; Female; Gonadotropin-Releasing Hormone; Hypothalamus; Hypothalamus, Middle; Letrozole; Macaca mulatta; Mass Spectrometry; Median Eminence; Microdialysis; Nitriles; Ovariectomy; Radioimmunoassay; Triazoles | 2013 |
Symptoms of endocrine treatment and outcome in the BIG 1-98 study.
Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Breast Neoplasms; Drug-Related Side Effects and Adverse Reactions; Female; Follow-Up Studies; Humans; Incidence; Letrozole; Middle Aged; Neoplasm Grading; Neoplasm Metastasis; Nitriles; Proportional Hazards Models; Retrospective Studies; Risk Factors; Tamoxifen; Time Factors; Treatment Outcome; Triazoles; Tumor Burden | 2014 |
Computational studies on the anastrozole and letrozole, effective chemotherapy drugs against breast cancer.
Topics: Anastrozole; Antineoplastic Agents; Breast Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; Computer Simulation; Female; Humans; Letrozole; Models, Molecular; Molecular Conformation; Nitriles; Proton Magnetic Resonance Spectroscopy; Static Electricity; Triazoles; Vibration | 2014 |
Assessment of a nonsteroidal aromatase inhibitor, letrozole, in juvenile rats.
Topics: Animals; Aromatase Inhibitors; Behavior, Animal; Body Weight; Bone Development; Dose-Response Relationship, Drug; Eating; Female; Letrozole; Male; Motor Activity; Nitriles; Rats; Rats, Sprague-Dawley; Reproduction; Spermatozoa; Triazoles | 2013 |
[An elderly patient with advanced breast cancer who responded to treatment with letrozole-a case report].
Topics: Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Humans; Letrozole; Neoplasm Invasiveness; Neoplasm Metastasis; Nitriles; Triazoles | 2013 |
[Luteal letrozole administration decreases serum estrogen level but not the risk of ovarian hyperstimulation syndrome].
Topics: Adult; Aromatase Inhibitors; Embryo Transfer; Estrogens; Female; Fertilization in Vitro; Humans; Infertility, Female; Letrozole; Luteal Phase; Luteinizing Hormone; Nitriles; Oocyte Retrieval; Ovarian Hyperstimulation Syndrome; Ovulation Induction; Progesterone; Triazoles | 2013 |
Norethisterone acetate versus norethisterone acetate combined with letrozole for the treatment of ovarian endometriotic cysts: a patient preference study.
Topics: Adult; Aromatase Inhibitors; Drug Therapy, Combination; Dysmenorrhea; Dyspareunia; Endometriosis; Female; Humans; Letrozole; Nitriles; Norethindrone; Norethindrone Acetate; Ovarian Cysts; Treatment Outcome; Triazoles | 2014 |
Women commencing anastrozole, letrozole or tamoxifen for early breast cancer: the impact of comorbidity and demographics on initial choice.
Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Australia; Breast Neoplasms; Cohort Studies; Comorbidity; Female; Humans; Letrozole; Middle Aged; Neoplasm Staging; Nitriles; Postmenopause; Practice Guidelines as Topic; Premenopause; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles; Tumor Burden | 2014 |
[A case of advanced breast carcinoma effectively treated postoperatively with tegafur-uracil].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Middle Aged; Neoplasm Staging; Nitriles; Tegafur; Triazoles | 2013 |
Inhibitory effects of aromatase inhibitor on estrogen receptor-alpha positive ovarian cancer in mice.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Hormonal; Apoptosis; Aromatase; Aromatase Inhibitors; Ascites; Cell Line, Tumor; Estrogen Receptor alpha; Female; Forkhead Transcription Factors; Humans; Letrozole; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Nitriles; Ovarian Neoplasms; Ovariectomy; Peritoneal Neoplasms; Repressor Proteins; Signal Transduction; Time Factors; Triazoles; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2014 |
Effect of dietary administration of letrozole and tamoxifen on gonadal development, sex differentiation and biochemical changes in common carp (Cyprinus carpio L.).
Topics: Animals; Aromatase Inhibitors; Carps; Estradiol; Estrogen Antagonists; Female; Gonads; Letrozole; Male; Nitriles; Sex Differentiation; Spermatogenesis; Tamoxifen; Triazoles | 2015 |
Tumour grade on core biopsy and evidence of axillary involvement on ultrasound predicts response in elderly co-morbid patients treated with primary hormone therapy for oestrogen receptor positive breast carcinoma.
Topics: Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents, Hormonal; Axilla; Biopsy, Large-Core Needle; Breast Neoplasms; Female; Humans; Letrozole; Lymph Nodes; Lymphatic Metastasis; Middle Aged; Nitriles; Receptors, Estrogen; Retrospective Studies; Tamoxifen; Triazoles | 2015 |
aP2-Cre-mediated inactivation of estrogen receptor alpha causes hydrometra.
Topics: Animals; Estradiol; Estrogen Receptor alpha; Estrous Cycle; Fatty Acid-Binding Proteins; Female; Gene Deletion; Infertility, Female; Integrases; Letrozole; Mice; Mice, Knockout; Nitriles; Triazoles; Up-Regulation; Uterus | 2014 |
Aromatase inhibitor letrozole downregulates steroid receptor coactivator-1 in specific brain regions that primarily related to memory, neuroendocrine and integration.
Topics: Animals; Aromatase Inhibitors; Brain Stem; Cerebellum; Diencephalon; Down-Regulation; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Hippocampus; Letrozole; Male; Memory; Mice; Mice, Inbred C57BL; Motor Cortex; Neurosecretory Systems; Nitriles; Nuclear Receptor Coactivator 1; Organ Specificity; Receptors, Androgen; Telencephalon; Triazoles | 2014 |
Body mass index and circulating oestrone sulphate in women treated with adjuvant letrozole.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Aromatase Inhibitors; Body Mass Index; Breast Neoplasms; Chemotherapy, Adjuvant; Estrone; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Triazoles | 2014 |
Efficacy and safety of Trastuzumab added to standard treatments for HER2-positive metastatic breast cancer patients.
Topics: Anastrozole; Anthracyclines; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Docetaxel; Female; Humans; Letrozole; Meta-Analysis as Topic; Nitriles; Paclitaxel; Prognosis; Randomized Controlled Trials as Topic; Receptor, ErbB-2; Taxoids; Trastuzumab; Triazoles | 2013 |
Letrozole dispersed on poly (vinyl alcohol) anchored maleic anhydride grafted low density polyethylene: a controlled drug delivery system for treatment of breast cancer.
Topics: Animals; Breast Neoplasms; Cell Adhesion; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Screening Assays, Antitumor; Female; Humans; Letrozole; Maleic Anhydrides; Mice; Molecular Structure; NIH 3T3 Cells; Nitriles; Polyethylene; Polyvinyl Alcohol; Structure-Activity Relationship; Triazoles | 2014 |
Nonhypoxic regulation and role of hypoxia-inducible factor 1 in aromatase inhibitor resistant breast cancer.
Topics: Antineoplastic Agents; Aromatase Inhibitors; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Cell Hypoxia; Drug Resistance, Neoplasm; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Letrozole; MCF-7 Cells; Neoplasm Proteins; Nitriles; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Receptor, ErbB-2; Receptors, Estrogen; RNA, Messenger; Spheroids, Cellular; TOR Serine-Threonine Kinases; Triazoles; Tumor Cells, Cultured | 2014 |
Clinical and laboratory patterns during immune stimulation in hormone responsive metastatic breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoembryonic Antigen; Cytokines; Disease Progression; Disease-Free Survival; Female; Humans; Immunity, Cellular; Immunotherapy; Interferon-beta; Interleukin-2; Letrozole; Middle Aged; Mucin-1; Neoplasm Metastasis; Neoplasms, Hormone-Dependent; Nitriles; Proportional Hazards Models; Selective Estrogen Receptor Modulators; T-Lymphocytes; Tamoxifen; Tissue Polypeptide Antigen; Toremifene; Triazoles | 2014 |
Influence networks based on coexpression improve drug target discovery for the development of novel cancer therapeutics.
Topics: Antineoplastic Agents; Breast Neoplasms; Computational Biology; Drug Discovery; Gene Expression Profiling; Humans; Letrozole; Molecular Targeted Therapy; Nitriles; Receptors, Estrogen; RNA, Messenger; Triazoles | 2014 |
A joint test for progression and survival with interval-censored data from a cancer clinical trial.
Topics: Antineoplastic Agents; Bias; Breast Neoplasms; Clinical Trials as Topic; Data Interpretation, Statistical; Disease Progression; Disease-Free Survival; Female; Humans; Letrozole; Models, Statistical; Nitriles; Triazoles | 2014 |
Dasatinib-letrozole gets split verdict.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Dasatinib; Female; Humans; Letrozole; Nitriles; Protein Kinase Inhibitors; Pyrimidines; Receptor, ErbB-2; Receptors, Estrogen; Thiazoles; Treatment Outcome; Triazoles | 2014 |
[Long-term results of personalized treatment in 72 breast cancer patients who failed chemotherapy].
Topics: Adult; Aged; Aromatase Inhibitors; Bone Density Conservation Agents; Bone Neoplasms; Brain Neoplasms; Breast Neoplasms; Carcinoma, Ductal, Breast; Chemotherapy, Adjuvant; Diphosphonates; Drugs, Chinese Herbal; Female; Follow-Up Studies; Humans; Imidazoles; Letrozole; Lung Neoplasms; Medicine, Chinese Traditional; Middle Aged; Neoplasm Staging; Nitriles; Radiotherapy, Adjuvant; Radiotherapy, Conformal; Remission Induction; Retrospective Studies; Survival Rate; Treatment Failure; Triazoles; Zoledronic Acid | 2013 |
Relationship of body mass index with aromatisation and plasma and tissue oestrogen levels in postmenopausal breast cancer patients treated with aromatase inhibitors.
Topics: Aged; Anastrozole; Androgens; Aromatase; Aromatase Inhibitors; Body Mass Index; Breast Neoplasms; Estradiol; Estrogens; Estrone; Female; Humans; Letrozole; Middle Aged; Nitriles; Outcome Assessment, Health Care; Postmenopause; Triazoles | 2014 |
Radiation recall reaction with letrozole therapy in breast cancer.
Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Humans; Letrozole; Nitriles; Radiodermatitis; Radiotherapy; Triazoles | 2014 |
The effects of exogenous melatonin and melatonin receptor blockade on aggression and estrogen-dependent gene expression in male California mice (Peromyscus californicus).
Topics: Aggression; Animals; Estrogen Receptor alpha; Estrogens; Gene Expression Regulation; Letrozole; Male; Melatonin; Nitriles; Peromyscus; Proto-Oncogene Proteins c-fos; Receptors, Melatonin; Receptors, Oxytocin; Triazoles; Tryptamines | 2014 |
Long-term outcome of neoadjuvant endocrine therapy with aromatase inhibitors in elderly women with hormone receptor-positive breast cancer.
Topics: Aged; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Chemotherapy, Adjuvant; Female; Follow-Up Studies; Humans; Letrozole; Neoadjuvant Therapy; Neoplasm Grading; Neoplasm Staging; Nitriles; Postmenopause; Prognosis; Receptor, ErbB-2; Retrospective Studies; Survival Rate; Tamoxifen; Time Factors; Triazoles | 2014 |
Biomarker changes associated with the development of resistance to aromatase inhibitors (AIs) in estrogen receptor-positive breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Androstadienes; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Drug Resistance, Neoplasm; Female; Humans; Insulin Receptor Substrate Proteins; Ki-67 Antigen; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Nitriles; PTEN Phosphohydrolase; Receptor, ErbB-2; Receptor, IGF Type 1; Receptors, Estrogen; Receptors, Progesterone; Retrospective Studies; Stathmin; Tamoxifen; Triazoles | 2014 |
The comparision of effect of microdose GnRH-a flare-up, GnRH antagonist/aromatase inhibitor letrozole and GnRH antagonist/clomiphene citrate protocols on IVF outcomes in poor responder patients.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Estradiol; Female; Gonadotropin-Releasing Hormone; Humans; Infertility, Female; Letrozole; Nitriles; Oocyte Retrieval; Ovarian Follicle; Ovulation Induction; Pregnancy; Retrospective Studies; Sperm Injections, Intracytoplasmic; Statistics, Nonparametric; Triazoles; Ultrasonography | 2014 |
Dysregulated estrogen receptor signaling in the hypothalamic-pituitary-ovarian axis leads to ovarian epithelial tumorigenesis in mice.
Topics: Animals; Carcinogenesis; Carcinoma, Ovarian Epithelial; Estrogen Receptor alpha; Estrogens; Female; Gene Expression Regulation, Neoplastic; Gonadotropin-Releasing Hormone; Humans; Hypothalamus; Letrozole; Mice; Neoplasms, Glandular and Epithelial; Nitriles; Ovarian Neoplasms; Ovary; Pituitary Gland; Signal Transduction; Triazoles | 2014 |
Persistent endocrine disruption effects in medaka fish with early life-stage exposure to a triazole-containing aromatase inhibitor (letrozole).
Topics: Animals; Aromatase Inhibitors; Embryo, Nonmammalian; Endocrine Disruptors; Larva; Letrozole; Nitriles; Oryzias; Sexual Maturation; Triazoles; Water Pollutants, Chemical | 2014 |
Acute but not sustained aromatase inhibition displays antidepressant properties.
Topics: Animals; Antidepressive Agents; Aromatase Inhibitors; Drug Administration Schedule; Estradiol; Female; Fluoxetine; Immobility Response, Tonic; Letrozole; Nitriles; Progesterone; Rats; Testosterone; Triazoles | 2014 |
Hormone dependency in metastatic low-grade leiomyosarcoma following uterine smooth muscle tumour of uncertain malignant potential.
Topics: Adult; Aromatase Inhibitors; Estrogen Replacement Therapy; Estrogens; Female; Humans; Hysterectomy; Leiomyosarcoma; Letrozole; Lung Neoplasms; Menopause; Neoplasms, Hormone-Dependent; Nitriles; Ovariectomy; Pleural Neoplasms; Radiography; Retroperitoneal Neoplasms; Salpingectomy; Triazoles; Uterine Neoplasms | 2014 |
Morphological and immunohistochemical analysis in ovaries and fallopian tubes of tamoxifen, letrozole and clomiphene-treated rats.
Topics: Animals; Cell Nucleus; Chromatin; Clomiphene; Epithelium; Fallopian Tubes; Female; Fertility Agents, Female; Immunohistochemistry; Letrozole; Nitriles; Ovary; Ovulation Induction; Rats; Rats, Wistar; Tamoxifen; Triazoles | 2014 |
Reduced endogenous estrogen and hemicastration interact synergistically to increase porcine sertoli cell proliferation.
Topics: Animals; Aromatase Inhibitors; Cell Count; Cell Proliferation; Estrogens; Follicle Stimulating Hormone; Inhibins; Letrozole; Luteinizing Hormone; Male; Nitriles; Random Allocation; Sertoli Cells; Swine; Testis; Testosterone; Triazoles | 2014 |
The effects of hormonotherapy administered concurrent radiotherapy and trastuzumab on cardiac toxicity in rats.
Topics: Anastrozole; Androstadienes; Animals; Antibodies, Monoclonal; Aromatase Inhibitors; Combined Modality Therapy; Drug Administration Schedule; Female; Heart; Humans; Letrozole; Nitriles; Radiotherapy; Rats; Rats, Wistar; Trastuzumab; Triazoles; Tumor Protein, Translationally-Controlled 1 | 2014 |
Kinetic analysis of [11C]vorozole binding in the human brain with positron emission tomography.
Topics: Adult; Aged; Aromatase Inhibitors; Carbon Radioisotopes; Cerebellum; Female; Humans; Letrozole; Male; Middle Aged; Nitriles; Positron-Emission Tomography; Thalamus; Tissue Distribution; Triazoles; Young Adult | 2014 |
Possible interaction between letrozole and long-acting injectable zuclopenthixol.
Topics: Aged; Antineoplastic Agents; Antipsychotic Agents; Basal Ganglia Diseases; Clopenthixol; Dibenzothiazepines; Drug Interactions; Female; Humans; Letrozole; Nitriles; Quetiapine Fumarate; Schizophrenia; Triazoles | 2015 |
Comparison of estradiol and progesterone priming/antagonist/letrozole and microdose flare-up protocols for poor responders undergoing intracytoplasmic sperm injection.
Topics: Adult; Estradiol; Female; Gonadotropin-Releasing Hormone; Humans; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Progesterone; Retrospective Studies; Sperm Injections, Intracytoplasmic; Triazoles | 2014 |
VAV3 mediates resistance to breast cancer endocrine therapy.
Topics: Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Breast; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Enzyme Activators; ErbB Receptors; Erlotinib Hydrochloride; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Genetic Association Studies; Genetic Variation; Humans; Indazoles; Letrozole; MCF-7 Cells; Nitriles; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-vav; Quinazolines; RNA Interference; RNA, Small Interfering; Tamoxifen; Toremifene; Triazoles | 2014 |
Palbociclib ups PFS in HER2-/ER+ breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Disease-Free Survival; Female; Humans; Letrozole; Nitriles; Piperazines; Protein Kinase Inhibitors; Pyridines; Receptor, ErbB-2; Receptors, Estrogen; Triazoles | 2014 |
Is there any cumulative dose for trastuzumab?
Topics: Adult; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Docetaxel; Echocardiography; Female; Heart Diseases; Humans; Letrozole; Nitriles; Receptor, ErbB-2; Taxoids; Trastuzumab; Triazoles | 2015 |
Low adherence to upfront and extended adjuvant letrozole therapy among early breast cancer patients in a clinical practice setting.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Middle Aged; Nitriles; Patient Compliance; Proportional Hazards Models; Treatment Refusal; Triazoles | 2014 |
A hard pill to swallow: a qualitative study of women's experiences of adjuvant endocrine therapy for breast cancer.
Topics: Aged; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Attitude to Health; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Medication Adherence; Middle Aged; Nitriles; Qualitative Research; Quality of Life; Tamoxifen; Triazoles | 2014 |
Anti-aromatase effect of resveratrol and melatonin on hormonal positive breast cancer cells co-cultured with breast adipose fibroblasts.
Topics: Adipose Tissue; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Cells, Cultured; Coculture Techniques; Estradiol; Female; Fibroblasts; Gene Expression Regulation; Humans; Ki-67 Antigen; Letrozole; Melatonin; Nitriles; Resveratrol; Stilbenes; Testosterone; Trefoil Factor-1; Triazoles; Tumor Suppressor Proteins | 2014 |
Weight loss interventions and breast cancer survival: the time is now.
Topics: Antineoplastic Agents; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Postmenopause; Telephone; Triazoles; Weight Loss | 2014 |
Is there a role for hormonal therapy in neuroendocrine carcinoma of the breast? A Paradigmatic case report.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Neuroendocrine; Cytodiagnosis; Diagnostic Errors; Female; Humans; Letrozole; Lymphatic Metastasis; Mastectomy; Middle Aged; Nitriles; Tamoxifen; Triazoles | 2014 |
Complex effects of two presumably antagonistic endocrine disrupting compounds on the goldfish Carassius aumtus: a comprehensive study with multiple toxicological endpoints.
Topics: Animals; Aromatase; Endocrine Disruptors; Estradiol; Goldfish; Letrozole; Liver; Male; Nitriles; Phenols; Receptors, Estrogen; Testis; Triazoles; Vitellogenins; Water Pollutants, Chemical | 2014 |
Reducing endogenous estrogen during prepuberal life does not affect boar libido or sperm fertilizing potential.
Topics: Animals; Aromatase Inhibitors; Breeding; Estrogens; Female; Fertilization; Letrozole; Male; Nitriles; Sertoli Cells; Sexual Behavior, Animal; Sexual Maturation; Spermatozoa; Swine; Testis; Triazoles | 2014 |
Clinical response to primary letrozole therapy in elderly patients with early breast cancer: possible role for p53 as a biomarker.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Disease-Free Survival; ErbB Receptors; Female; Humans; Letrozole; Nitriles; Pilot Projects; Proto-Oncogene Proteins c-bcl-2; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Retrospective Studies; Tamoxifen; Triazoles; Tumor Suppressor Protein p53 | 2014 |
[The use of letrozole in ovarian cancer].
Topics: Antineoplastic Agents; Aromatase Inhibitors; Female; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Ovarian Neoplasms; Treatment Outcome; Triazoles | 2014 |
Protective effects of testosterone on presynaptic terminals against oligomeric β-amyloid peptide in primary culture of hippocampal neurons.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Hippocampus; Humans; Letrozole; Neurons; Nitriles; Presynaptic Terminals; Primary Cell Culture; Protective Agents; Rats; Testosterone; Triazoles | 2014 |
Molecular changes in lobular breast cancers in response to endocrine therapy.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Carcinoma, Lobular; Cohort Studies; Female; Humans; Letrozole; Nitriles; Postmenopause; Triazoles | 2014 |
Coadministrating luteolin minimizes the side effects of the aromatase inhibitor letrozole.
Topics: Animals; Apoptosis Regulatory Proteins; Aromatase Inhibitors; Cell Cycle; Cell Line, Tumor; Estradiol; Female; Letrozole; Lipoproteins, HDL; Luteolin; MCF-7 Cells; Mice; Mice, Nude; Nitriles; Triazoles | 2014 |
Investigation of aromatase inhibitory activity of metal complexes of 8-hydroxyquinoline and uracil derivatives.
Topics: Aromatase Inhibitors; Cell Line; Coordination Complexes; Copper; Humans; Inhibitory Concentration 50; Ketoconazole; Letrozole; Lung; Manganese; Nickel; Nitriles; Oxyquinoline; Triazoles; Uracil | 2014 |
Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome.
Topics: Animals; Anti-Mullerian Hormone; Aromatase Inhibitors; Disease Models, Animal; Female; Letrozole; Nitriles; Ovarian Follicle; Ovary; Polycystic Ovary Syndrome; Rats; Rats, Sprague-Dawley; Receptors, Peptide; Receptors, Transforming Growth Factor beta; Testosterone; Triazoles | 2014 |
Reproductive endocrinology: revisiting ovulation induction in PCOS.
Topics: Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Treatment Outcome; Triazoles | 2014 |
Synergistic in vitro anti-tumor effect of letrozole and everolimus on human endometrial carcinoma Ishikawa cells.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Synergism; Endometrial Neoplasms; Everolimus; Female; Humans; Letrozole; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoproteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Sirolimus; TOR Serine-Threonine Kinases; Triazoles | 2014 |
Use of aromatase inhibitors in large cell calcifying sertoli cell tumors: effects on gynecomastia, growth velocity, and bone age.
Topics: AMP-Activated Protein Kinase Kinases; Anastrozole; Antineoplastic Agents; Aromatase Inhibitors; Bone Development; Calcinosis; Carney Complex; Child; Child, Preschool; Growth; Gynecomastia; Humans; Infant; Letrozole; Male; Nitriles; Peutz-Jeghers Syndrome; Protein Serine-Threonine Kinases; Sertoli Cell Tumor; Treatment Outcome; Triazoles | 2014 |
Placental estrogen suppresses cyclin D1 expression in the nonhuman primate fetal adrenal cortex.
Topics: Adrenal Cortex; Animals; Aromatase Inhibitors; Carrier Proteins; Cyclin D1; Cyclin-Dependent Kinases; Dehydroepiandrosterone Sulfate; Estradiol; Estrogens; Female; Fetal Development; Fetal Weight; Hydrocortisone; Ki-67 Antigen; Letrozole; Male; Nitriles; Papio anubis; Placenta; Pregnancy; Triazoles | 2014 |
GC-MS analysis of Cocus nucifera flower extract and its effects on heterogeneous symptoms of polycystic ovarian disease in female Wistar rats.
Topics: Animals; Antioxidants; Blood Glucose; Cocos; Estrus; Female; Flowers; Gas Chromatography-Mass Spectrometry; Hypoglycemic Agents; Letrozole; Lipids; Nitriles; Oils, Volatile; Ovary; Phytoestrogens; Phytotherapy; Plant Extracts; Polycystic Ovary Syndrome; Rats, Wistar; Triazoles; Uterus | 2014 |
Congenital malformations among babies born following letrozole or clomiphene for infertility treatment.
Topics: Birth Weight; Child; Child, Preschool; Clomiphene; Congenital Abnormalities; Female; Fertility Agents, Female; Humans; Incidence; Infant; Infant, Newborn; Infertility, Female; Letrozole; Male; Nitriles; Pregnancy; Retrospective Studies; Triazoles | 2014 |
Arthralgia induced by endocrine treatment for breast cancer: A prospective study of serum levels of insulin like growth factor-I, its binding protein and oestrogens.
Topics: Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Arthralgia; Breast Neoplasms; Chemotherapy, Adjuvant; Estrogens; Female; Humans; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Letrozole; Middle Aged; Musculoskeletal Pain; Nitriles; Prospective Studies; Tamoxifen; Triazoles | 2014 |
The immunoexpression of androgen receptor, estrogen receptors alpha and beta, vanilloid type 1 receptor and cytochrome p450 aromatase in rats testis chronically treated with letrozole, an aromatase inhibitor.
Topics: Animals; Aromatase Inhibitors; Cytochrome P-450 Enzyme System; Estrogen Receptor alpha; Estrogen Receptor beta; Immunohistochemistry; Letrozole; Male; Nitriles; Rats; Rats, Wistar; Receptors, Androgen; Testis; Triazoles; TRPV Cation Channels | 2014 |
Longitudinal trends in utilization of endocrine therapies for breast cancer: an international comparison.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Australia; Breast Neoplasms; Developed Countries; Drug Utilization Review; England; Female; France; Humans; Internationality; Letrozole; Longitudinal Studies; Netherlands; Nitriles; Scandinavian and Nordic Countries; Tamoxifen; Triazoles | 2015 |
Functional investigation on aromatase in endometrial hyperplasia in polycystic ovary syndrome cases.
Topics: Androgens; Aromatase; Aromatase Inhibitors; Blotting, Western; Case-Control Studies; Cells, Cultured; Endometrial Hyperplasia; Endometrium; Estradiol; Female; Gene Expression Regulation, Enzymologic; Humans; Immunoenzyme Techniques; Letrozole; Nitriles; Polycystic Ovary Syndrome; Prognosis; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Testosterone; Triazoles | 2014 |
Primary Hormonal Therapy for Elderly Breast Cancer Patients: Single Institution Experience.
Topics: Aged; Aged, 80 and over; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Breast Neoplasms; Estradiol; Female; Fulvestrant; Humans; Letrozole; Nitriles; Receptors, Estrogen; Retrospective Studies; Spain; Tamoxifen; Treatment Outcome; Triazoles | 2015 |
Budget impact analysis of everolimus for the treatment of hormone receptor positive, human epidermal growth factor receptor-2 negative (HER2-) advanced breast cancer in Kazakhstan.
Topics: Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cost-Benefit Analysis; Disease Progression; Everolimus; Female; Humans; Kazakhstan; Letrozole; Nitriles; Postmenopause; Receptor, ErbB-2; Triazoles | 2015 |
Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance.
Topics: Animals; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Biomarkers, Tumor; BRCA1 Protein; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Flow Cytometry; Gene Expression Profiling; Gene Regulatory Networks; Humans; Immune System Phenomena; Immunoenzyme Techniques; Letrozole; Mammary Neoplasms, Animal; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Nitriles; Oligonucleotide Array Sequence Analysis; Precancerous Conditions; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tamoxifen; Triazoles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2015 |
Chronology, magnitude and duration of expression of putative sex-determining/differentiation genes in a turtle with temperature-dependent sex determination.
Topics: Adrenal Glands; Animals; Embryo, Nonmammalian; Estradiol; Female; Gene Expression Regulation, Developmental; Gonads; Kidney; Letrozole; Male; Nitriles; Real-Time Polymerase Chain Reaction; Sex Determination Processes; Sex Differentiation; Temperature; Time Factors; Triazoles; Turtles | 2014 |
A comparison of the efficacy of two doses of letrozole alone or with continuous recombinant follicle-stimulating hormone for ovulation induction in anovulatory women.
Topics: Adult; Anovulation; Aromatase Inhibitors; Drug Therapy, Combination; Female; Follicle Stimulating Hormone; Humans; Insemination, Artificial; Letrozole; Nitriles; Ovulation Induction; Treatment Outcome; Triazoles | 2015 |
Morphea following radiation therapy in a patient with breast cancer.
Topics: Antineoplastic Agents, Hormonal; Breast Diseases; Breast Neoplasms; Carcinoma, Ductal, Breast; Combined Modality Therapy; Female; Humans; Letrozole; Mastectomy, Segmental; Middle Aged; Nitriles; Radiation Injuries; Radiotherapy, High-Energy; Scleroderma, Localized; Triazoles | 2015 |
17α-estradiol is generated locally in the male rat brain and can regulate GAD65 expression and anxiety.
Topics: Animals; Anxiety; Brain; Cells, Cultured; Central Nervous System Agents; Estradiol; Estrogens; Glutamate Decarboxylase; Immunohistochemistry; Letrozole; Male; Microscopy, Fluorescence; Motor Activity; Nitriles; Rats, Wistar; Triazoles | 2015 |
Prenatal hyperandrogenic environment induced autistic-like behavior in rat offspring.
Topics: Androgens; Animals; Arginine Vasopressin; Child Development Disorders, Pervasive; Disease Models, Animal; Estrous Cycle; Female; Letrozole; Male; Nitriles; Oxytocin; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Receptors, Vasopressin; RNA, Messenger; Sex Characteristics; Social Behavior; Sound; Testosterone; Triazoles; Vocalization, Animal | 2015 |
Combination of letrozole, metronomic cyclophosphamide and sorafenib is well-tolerated and shows activity in patients with primary breast cancer.
Topics: Administration, Metronomic; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Cyclophosphamide; Female; Humans; Letrozole; Middle Aged; Niacinamide; Nitriles; Phenylurea Compounds; Randomized Controlled Trials as Topic; Sorafenib; Triazoles | 2015 |
Prenatal letrozole produces a subpopulation of male rats with same-sex preference and arousal as well as female sexual behavior.
Topics: Animals; Aromatase Inhibitors; Dose-Response Relationship, Drug; Estradiol; Female; Follicle Stimulating Hormone; Letrozole; Luteinizing Hormone; Male; Nitriles; Penile Erection; Posture; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Wistar; Sexual Behavior, Animal; Testosterone; Triazoles | 2015 |
Steroidal and non-steroidal third-generation aromatase inhibitors induce pain-like symptoms via TRPA1.
Topics: Anastrozole; Androstadienes; Animals; Aromatase Inhibitors; Behavior, Animal; Calcium; Calcium Channels; Cysteine; HEK293 Cells; Humans; Inflammation; Letrozole; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neuropeptides; Nitriles; Pain; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Steroids; Transient Receptor Potential Channels; Triazoles; TRPA1 Cation Channel; TRPC Cation Channels | 2014 |
First reported case of sextuplets conceived via letrozole for ovulation induction.
Topics: Adult; Aromatase Inhibitors; Female; Humans; Infertility, Female; Letrozole; Multiple Birth Offspring; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Triazoles | 2015 |
[Effect of sex inversion in embryos of domestic chicken (Gallu gallus domesticus) by influence of letrozole and tamoxifen].
Topics: Animals; Aromatase Inhibitors; Chick Embryo; Chickens; Chromosome Mapping; Estrogen Antagonists; Estrogen Receptor alpha; Female; Gene Expression; Genetic Loci; Gonadal Dysgenesis; Humans; Letrozole; Male; Nitriles; Ovary; Prophase; Protein Interaction Mapping; Sex Chromosomes; Sex Differentiation; Tamoxifen; Testis; Triazoles | 2014 |
Design, synthesis, docking study and cytotoxic activity evaluation of some novel letrozole analogs.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Cell Proliferation; Cell Survival; Computer-Aided Design; Dose-Response Relationship, Drug; Drug Design; Female; Humans; Inhibitory Concentration 50; Letrozole; MCF-7 Cells; Molecular Docking Simulation; Molecular Structure; Nitriles; Structure-Activity Relationship; Triazoles | 2014 |
Hydrolysis of Letrozole catalyzed by macrocyclic Rhodium (I) Schiff-base complexes.
Topics: Carbon-13 Magnetic Resonance Spectroscopy; Catalysis; Electric Conductivity; Electrons; Hydrolysis; Letrozole; Macrocyclic Compounds; Magnetic Phenomena; Mass Spectrometry; Nitriles; Proton Magnetic Resonance Spectroscopy; Rhodium; Schiff Bases; Spectrophotometry, Infrared; Triazoles | 2015 |
Cellular and molecular mechanisms of pentoxifylline's beneficial effects in experimental polycystic ovary.
Topics: Animals; Aromatase Inhibitors; Biomarkers; Female; Letrozole; Nitriles; Oxidative Stress; Pentoxifylline; Polycystic Ovary Syndrome; Rats; Rats, Wistar; Reactive Oxygen Species; Triazoles; Vasodilator Agents | 2015 |
Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis.
Topics: Animals; Anti-Inflammatory Agents; Cell Survival; Cells, Cultured; Disease Models, Animal; Disease Progression; Drug Therapy, Combination; Embryonic Stem Cells; Endometriosis; Estrogens; Female; Fertility; Humans; Indazoles; Inflammation; Letrozole; Ligands; Macrophages; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Nitriles; Receptors, Estrogen; Stromal Cells; Treatment Outcome; Triazoles | 2015 |
Inhibition of Testosterone Aromatization by the Indole-3-carbinol Derivative CTet in CYP19A1-overexpressing MCF-7 Breast Cancer Cells.
Topics: Active Transport, Cell Nucleus; Anticarcinogenic Agents; Aromatase; Aromatase Inhibitors; Cell Nucleus; Cell Proliferation; Cycloparaffins; Drug Synergism; Endoplasmic Reticulum Stress; Estradiol; Estrogen Receptor alpha; Humans; Indoles; Letrozole; MCF-7 Cells; Nitriles; Phosphorylation; Response Elements; Testosterone; Triazoles | 2015 |
New cell culture model for aromatase inhibitor-resistant breast cancer shows sensitivity to fulvestrant treatment and cross-resistance between letrozole and exemestane.
Topics: Androstadienes; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Cell Culture Techniques; Cell Proliferation; Drug Resistance, Neoplasm; Estradiol; Female; Fulvestrant; Gene Expression Regulation, Neoplastic; Humans; Letrozole; MCF-7 Cells; Models, Biological; Nitriles; Tamoxifen; Triazoles | 2015 |
MicroRNA-125b upregulation confers aromatase inhibitor resistance and is a novel marker of poor prognosis in breast cancer.
Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Cluster Analysis; Cohort Studies; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Letrozole; MCF-7 Cells; MicroRNAs; Neoplasm Recurrence, Local; Nitriles; Phosphatidylinositol 3-Kinases; Prognosis; Proto-Oncogene Proteins c-akt; Receptors, Estrogen; Signal Transduction; TOR Serine-Threonine Kinases; Triazoles; Tumor Cells, Cultured; Up-Regulation | 2015 |
Minimal stimulation using gonadotropin combined with clomiphene citrate or letrozole for intrauterine insemination.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Administration Schedule; Drug Combinations; Female; Fertility Agents, Female; Fertilization in Vitro; Gonadotropins; Humans; Infertility, Female; Insemination, Artificial; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Treatment Outcome; Triazoles | 2015 |
Preclinical pharmacological evaluation of letrozole as a novel treatment for gliomas.
Topics: Animals; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Activation; Female; Gene Expression; Glioma; Humans; Letrozole; Nitriles; Positron-Emission Tomography; Rats; Triazoles; X-Ray Microtomography; Xenograft Model Antitumor Assays | 2015 |
Aromatase imaging with [N-methyl-11C]vorozole PET in healthy men and women.
Topics: Adult; Age Factors; Aged; Aromatase; Aromatase Inhibitors; Diagnostic Imaging; Female; Healthy Volunteers; Humans; Letrozole; Liver; Male; Middle Aged; Nitriles; Positron-Emission Tomography; Radiometry; Radiopharmaceuticals; Reproducibility of Results; Sex Factors; Software; Triazoles; Whole-Body Irradiation; Young Adult | 2015 |
In defense of publishing baseline data from clinical trials.
Topics: Clomiphene; Female; Fertility Agents, Female; Gonadotropins; Humans; Infertility, Female; Letrozole; Male; Nitriles; Ovulation Induction; Pregnancy; Pregnancy, Multiple; Triazoles | 2015 |
A Case of Metastatic Low-Grade Endometrial Stromal Sarcoma Treated with Letrozole after Ovarian Ablation by Radiotherapy.
Topics: Ablation Techniques; Antineoplastic Agents; Chemotherapy, Adjuvant; Endometrial Neoplasms; Female; Humans; Letrozole; Middle Aged; Nitriles; Radiotherapy; Sarcoma, Endometrial Stromal; Triazoles | 2015 |
Surgical resection of a liver metastasis from breast cancer.
Topics: Aged; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Liver Neoplasms; Lymph Node Excision; Mastectomy; Nitriles; Triazoles | 2015 |
Efficacy of random-start controlled ovarian stimulation in cancer patients.
Topics: Cryopreservation; Estradiol; Female; Fertility Preservation; Fertilization in Vitro; Humans; Infertility, Female; Letrozole; Neoplasms; Nitriles; Oocyte Retrieval; Ovulation Induction; Retrospective Studies; Triazoles | 2015 |
Serotonin 2C receptor contributes to gender differences in stress-induced hypophagia in aged mice.
Topics: Age Factors; Aminopyridines; Animals; Anorexia; Aromatase Inhibitors; Brain; Corticosterone; ERRalpha Estrogen-Related Receptor; Feeding Behavior; Female; Ghrelin; Indoles; Letrozole; Male; Mice; Nitriles; Paraventricular Hypothalamic Nucleus; Phenols; Piperazines; Pyrazines; Pyrazoles; Receptor, Serotonin, 5-HT2C; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Sex Factors; Stress, Psychological; Triazoles | 2015 |
Management of Premenopausal Women with Neoadjuvant Endocrine Therapy: A Single-Institution Experience.
Topics: Adult; Anastrozole; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Chemotherapy, Adjuvant; Female; Gonadotropin-Releasing Hormone; Humans; Letrozole; Middle Aged; Neoadjuvant Therapy; Nitriles; Premenopause; Receptors, Estrogen; Response Evaluation Criteria in Solid Tumors; Tamoxifen; Triazoles | 2015 |
Thuja occidentalis L. and its active compound, α-thujone: Promising effects in the treatment of polycystic ovary syndrome without inducing osteoporosis.
Topics: Animals; Bicyclic Monoterpenes; Blood Glucose; Catalase; Estradiol; Female; Glutathione Peroxidase; Leptin; Letrozole; Lipids; Luteinizing Hormone; Malondialdehyde; Monoterpenes; Nitriles; Oils, Volatile; Osteoporosis; Phytotherapy; Polycystic Ovary Syndrome; Progesterone; Rats, Sprague-Dawley; Superoxide Dismutase; Testosterone; Thuja; Triazoles | 2015 |
Aromatase expression increases the survival and malignancy of estrogen receptor positive breast cancer cells.
Topics: Animals; Anoikis; Aromatase; Aromatase Inhibitors; Bone Neoplasms; Breast Neoplasms; Carcinoma, Ductal; Cell Line, Tumor; Estrogen Receptor alpha; Estrogens; Female; Gene Expression Regulation, Neoplastic; Humans; Letrozole; Mice; Mice, Nude; Neoplasm Transplantation; Nitriles; Signal Transduction; Testosterone; Triazoles; Tumor Cells, Cultured | 2015 |
The effect of estrogen synthesis inhibition on hippocampal memory.
Topics: Aged; Anastrozole; Estradiol; Female; Gyrus Cinguli; Hippocampus; Humans; Letrozole; Long-Term Potentiation; Longitudinal Studies; Magnetic Resonance Imaging; Memory; Memory, Short-Term; Middle Aged; Nitriles; Postmenopause; Prefrontal Cortex; Psychomotor Performance; Steroid Synthesis Inhibitors; Surveys and Questionnaires; Triazoles; Verbal Learning; Word Association Tests | 2015 |
Steroid regulation of early postnatal development in the corpus epididymidis of pigs.
Topics: Androgen Receptor Antagonists; Animals; Aromatase; Aromatase Inhibitors; Blood-Testis Barrier; Epididymis; Estradiol; Estrogen Receptor Antagonists; Flutamide; Fulvestrant; Letrozole; Male; Microscopy, Electron, Transmission; Nitriles; Protein Isoforms; Receptors, Androgen; Receptors, Estrogen; Receptors, G-Protein-Coupled; Sexual Development; Signal Transduction; Sus scrofa; Tight Junctions; Triazoles | 2015 |
Effects of 17α-Methyltestosterone and Aromatase Inhibitor Letrozole on Sex Reversal, Gonadal Structure, and Growth in Yellow Catfish Pelteobagrus fulvidraco.
Topics: Anabolic Agents; Animals; Aromatase Inhibitors; Catfishes; Disorders of Sex Development; Female; Gonads; Growth; Letrozole; Male; Methyltestosterone; Nitriles; Sex Ratio; Spermatogenesis; Triazoles | 2015 |
[Study on the oxidative stress in the ovaries of a rat model of polycystic ovary].
Topics: Animals; Antioxidants; Disease Models, Animal; Estrogens; Female; Follicle Stimulating Hormone; Letrozole; Luteinizing Hormone; Malondialdehyde; Nitriles; Ovary; Oxidative Stress; Polycystic Ovary Syndrome; Progesterone; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Testosterone; Triazoles | 2015 |
Basal and therapy-driven hypoxia-inducible factor-1α confers resistance to endocrine therapy in estrogen receptor-positive breast cancer.
Topics: Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Diphosphonates; Drug Resistance, Neoplasm; Estradiol; Estrogens; Female; Fulvestrant; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Letrozole; MAP Kinase Signaling System; Mice; Mice, Nude; Neoadjuvant Therapy; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Neovascularization, Pathologic; Nitriles; Postmenopause; Receptors, Estrogen; RNA Interference; RNA, Small Interfering; Transcription, Genetic; Treatment Outcome; Triazoles; Xenograft Model Antitumor Assays; Zoledronic Acid | 2015 |
Dual targeting of TNF-α and free radical toxic stress as a promising strategy to manage experimental polycystic ovary.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Disease Models, Animal; Drug Therapy, Combination; Female; Gonadal Steroid Hormones; Hyperandrogenism; Inflammation Mediators; Letrozole; Lipid Peroxidation; Nitriles; Ovary; Oxidative Stress; Plant Extracts; Polycystic Ovary Syndrome; Rats, Wistar; Reactive Oxygen Species; Triazoles; Tumor Necrosis Factor-alpha | 2016 |
[Long-term survival of a breast cancer patient with carcinomatous pleuritis and carcinomatous cardiac tamponade successfully treated by multimodality therapy].
Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Cardiac Tamponade; Combined Modality Therapy; Female; Humans; Letrozole; Nitriles; Paclitaxel; Pleurisy; Triazoles | 2015 |
The introduction of generic aromatase inhibitors and treatment adherence among Medicare D enrollees.
Topics: Aged; Aged, 80 and over; Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Cohort Studies; Drug Costs; Drugs, Generic; Evaluation Studies as Topic; Female; Humans; Letrozole; Medicare; Medication Adherence; Nitriles; Non-Randomized Controlled Trials as Topic; Poverty; Triazoles; United States | 2015 |
Adjuvant treatments of breast cancer increase the risk of depressive disorders: A population-based study.
Topics: Adult; Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Depressive Disorder; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Letrozole; Middle Aged; Nitriles; Population Surveillance; Proportional Hazards Models; Retrospective Studies; Risk; Taiwan; Tamoxifen; Trastuzumab; Triazoles | 2015 |
Aromatase Inhibitor-Mediated Downregulation of INrf2 (Keap1) Leads to Increased Nrf2 and Resistance in Breast Cancer.
Topics: Anastrozole; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Down-Regulation; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; Letrozole; MCF-7 Cells; Molecular Structure; NF-E2-Related Factor 2; Nitriles; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Triazoles; Ubiquitination | 2015 |
Structure-function-behavior relationship in estrogen-induced synaptic plasticity.
Topics: Animals; Aromatase; Aromatase Inhibitors; Behavior, Animal; Cognition; Dendritic Spines; Estradiol; Female; Hippocampus; Humans; Letrozole; Long-Term Potentiation; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Neurons; Nitriles; Rats; Synapses; Triazoles | 2015 |
Accurate Prediction and Validation of Response to Endocrine Therapy in Breast Cancer.
Topics: Antineoplastic Agents, Hormonal; Apoptosis Regulatory Proteins; Aromatase Inhibitors; Biomarkers, Tumor; Biopsy; Breast Neoplasms; Chemotherapy, Adjuvant; Cytokine Receptor gp130; Disease-Free Survival; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Letrozole; Minichromosome Maintenance Complex Component 4; Neoadjuvant Therapy; Nerve Tissue Proteins; Nitriles; Oligonucleotide Array Sequence Analysis; Precision Medicine; Predictive Value of Tests; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Treatment Outcome; Triazoles; Ultrasonography | 2015 |
Male rats with same sex preference show high experimental anxiety and lack of anxiogenic-like effect of fluoxetine in the plus maze test.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Enzyme Inhibitors; Exploratory Behavior; Female; Fluoxetine; Homosexuality, Male; Letrozole; Male; Motor Activity; Nitriles; Rats; Rats, Wistar; Sex Characteristics; Triazoles | 2015 |
Colocalization of aromatase in spinal cord astrocytes: differences in expression and relationship to mechanical and thermal hyperalgesia in murine models of a painful and a non-painful bone tumor.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Aromatase; Bone Neoplasms; Cell Line, Tumor; Disease Models, Animal; Fibrosarcoma; Gene Expression Regulation, Neoplastic; Glial Fibrillary Acidic Protein; Hyperalgesia; Letrozole; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Microglia; Nerve Tissue Proteins; Nitriles; Pain; Pain Threshold; Spinal Cord; Triazoles | 2015 |
Palbociclib for the Treatment of Estrogen Receptor-Positive, HER2-Negative Metastatic Breast Cancer.
Topics: Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Cyclin-Dependent Kinase 4; Disease-Free Survival; Drug Approval; Estrogen Receptor alpha; Female; Humans; Letrozole; Molecular Targeted Therapy; Neoplasm Metastasis; Nitriles; Piperazines; Pyridines; Randomized Controlled Trials as Topic; Receptor, ErbB-2; Triazoles | 2015 |
Fertility Preservation Success Subsequent to Concurrent Aromatase Inhibitor Treatment and Ovarian Stimulation in Women With Breast Cancer.
Topics: Adult; Aromatase Inhibitors; Breast Neoplasms; Cryopreservation; Embryo, Mammalian; Female; Fertility Preservation; Follicle Stimulating Hormone; Follow-Up Studies; Humans; Infertility, Female; Letrozole; Neoplasm Staging; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Outcome; Treatment Outcome; Triazoles; United States | 2015 |
Adjuvant regimens with trastuzumab administered for small HER2-positive breast cancer in routine clinical practice.
Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carboplatin; Chemoradiotherapy; Chemotherapy, Adjuvant; Cross-Sectional Studies; Cyclophosphamide; Docetaxel; Doxorubicin; Female; Humans; Letrozole; Middle Aged; Nitriles; Paclitaxel; Receptor, ErbB-2; Tamoxifen; Taxoids; Trastuzumab; Triazoles | 2015 |
Healthcare professionals' preferences for surgery or primary endocrine therapy to treat older women with operable breast cancer.
Topics: Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents, Hormonal; Attitude of Health Personnel; Breast Neoplasms; Female; Geriatrics; Humans; Letrozole; Mastectomy; Nitriles; Oncology Nursing; Patient Preference; Receptors, Estrogen; Surgeons; Surveys and Questionnaires; Tamoxifen; Triazoles; United Kingdom | 2015 |
Progesterone levels in letrozole associated controlled ovarian stimulation for fertility preservation in breast cancer patients.
Topics: Adult; Aromatase Inhibitors; Breast Neoplasms; Estradiol; Female; Fertility Preservation; Fertilization in Vitro; Gonadotropin-Releasing Hormone; Humans; Infertility, Female; Letrozole; Luteal Phase; Nitriles; Ovulation Induction; Progesterone; Sperm Injections, Intracytoplasmic; Triazoles | 2015 |
A nude mouse model of obesity to study the mechanisms of resistance to aromatase inhibitors.
Topics: Adipose Tissue; Animals; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Blood Glucose; Cell Line, Tumor; Cyclooxygenase 2; Diet; Disease Models, Animal; Drug Resistance, Neoplasm; Estrogens; Humans; Insulin; Letrozole; Mice, Nude; Neoplasms; Nitriles; Obesity; Ovariectomy; Triazoles; Tumor Burden | 2015 |
A comparison of endometrial thickness following augmentation of ovulation with clomifene citrate or letrozole in women with ovulatory infertility.
Topics: Adult; Clomiphene; Endometrium; Female; Fertility Agents, Female; Follicle Stimulating Hormone; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation; Random Allocation; Sri Lanka; Triazoles | 2015 |
Histone deacetylase inhibitor entinostat in combination with a retinoid downregulates HER2 and reduces the tumor initiating cell population in aromatase inhibitor-resistant breast cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Benzamides; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Histone Deacetylase Inhibitors; Humans; Letrozole; Mice, Nude; Nitriles; Pyridines; Receptor, ErbB-2; Tretinoin; Triazoles; Xenograft Model Antitumor Assays | 2015 |
Three-month treatment with triptorelin, letrozole and ulipristal acetate before hysteroscopic resection of uterine myomas: prospective comparative pilot study.
Topics: Adult; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Attitude of Health Personnel; Contraceptive Agents; Female; Humans; Hysteroscopy; Leiomyoma; Letrozole; Nitriles; Norpregnadienes; Operative Time; Pain, Postoperative; Patient Satisfaction; Pilot Projects; Prospective Studies; Triazoles; Triptorelin Pamoate; Tumor Burden; Uterine Neoplasms | 2015 |
Hypogonadism Associated with Cyp19a1 (Aromatase) Posttranscriptional Upregulation in Celf1 Knockout Mice.
Topics: Animals; Aromatase; Aromatase Inhibitors; CELF1 Protein; Cytochrome P-450 CYP1A1; Down-Regulation; Estradiol; Hypogonadism; Letrozole; Mice; Mice, Knockout; Myotonic Dystrophy; Nitriles; Protein Binding; Protein Biosynthesis; Spermatogenesis; Testosterone; Triazoles; Up-Regulation | 2015 |
[Clinical Efficacy of Alternate-Day S-1/Letrozole Combination Therapy for Advanced Breast Cancer with Gastric Metastasis--A Case Report].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Lobular; Drug Combinations; Female; Humans; Letrozole; Middle Aged; Nitriles; Oxonic Acid; Stomach Neoplasms; Tegafur; Treatment Outcome; Triazoles | 2015 |
A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice.
Topics: Animals; Corpus Luteum; Diestrus; Enzyme Inhibitors; Estrous Cycle; Female; Hyperandrogenism; Hypothalamus; Kisspeptins; Letrozole; Mice; Mice, Inbred C57BL; Nitriles; Phenotype; Pituitary Gland; Polycystic Ovary Syndrome; Pregnancy; Reproduction; Testosterone; Triazoles | 2015 |
Steroid receptor coactivator-1 mediates letrozole induced downregulation of postsynaptic protein PSD-95 in the hippocampus of adult female rats.
Topics: Animals; Aromatase Inhibitors; Cells, Cultured; Disks Large Homolog 4 Protein; Down-Regulation; Female; Gene Knockdown Techniques; Hippocampus; Intracellular Signaling Peptides and Proteins; Letrozole; Membrane Proteins; Nitriles; Nuclear Receptor Coactivator 1; Rats; Rats, Wistar; RNA Interference; Triazoles | 2015 |
Evaluation of response to hormone therapy in patients with measurable adult granulosa cell tumors of the ovary.
Topics: Adult; Aged; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Chemotherapy, Adjuvant; Disease Progression; Disease-Free Survival; Female; Goserelin; Granulosa Cell Tumor; Humans; Letrozole; Megestrol Acetate; Middle Aged; Nitriles; Ovarian Neoplasms; Ovariectomy; Radiotherapy, Adjuvant; Receptors, Estrogen; Receptors, Progesterone; Retrospective Studies; Salpingectomy; Tamoxifen; Triazoles | 2015 |
Picking the optimal endocrine adjuvant treatment for pre-menopausal women.
Topics: Age Factors; Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Goserelin; Humans; Letrozole; Nitriles; Ovary; Premenopause; Tamoxifen; Triazoles | 2015 |
Neoadjuvant endocrine therapy: Patient selection, treatment duration and surrogate endpoints.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Ki-67 Antigen; Letrozole; Neoadjuvant Therapy; Neoplasm Staging; Nitriles; Patient Selection; Prognosis; Tamoxifen; Time Factors; Triazoles | 2015 |
Zoledronic acid for treatment of osteopenia and osteoporosis in women with primary breast cancer undergoing adjuvant aromatase inhibitor therapy: a 5-year follow-up.
Topics: Adjuvants, Pharmaceutic; Aged; Aged, 80 and over; Aromatase Inhibitors; Bone Density; Bone Density Conservation Agents; Bone Diseases, Metabolic; Breast Neoplasms; Chemotherapy, Adjuvant; Diphosphonates; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Imidazoles; Letrozole; Lumbar Vertebrae; Middle Aged; Nitriles; Osteoporosis; Triazoles; Zoledronic Acid | 2016 |
Seribantumab, an Anti-ERBB3 Antibody, Delays the Onset of Resistance and Restores Sensitivity to Letrozole in an Estrogen Receptor-Positive Breast Cancer Model.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Drug Resistance, Neoplasm; Female; Humans; Immunoblotting; Letrozole; Mice, Inbred BALB C; Mice, Nude; Neuregulin-1; Nitriles; Ovariectomy; Phosphatidylinositol 3-Kinases; Phosphorylation; Receptor, ErbB-3; Receptors, Estrogen; Signal Transduction; TOR Serine-Threonine Kinases; Triazoles; Xenograft Model Antitumor Assays | 2015 |
Development and validation of a rapid LC-MS/MS method to quantify letrozole in human plasma and its application to therapeutic drug monitoring.
Topics: Anastrozole; Antineoplastic Agents; Chromatography, Liquid; Drug Monitoring; Humans; Letrozole; Limit of Detection; Nitriles; Tandem Mass Spectrometry; Triazoles | 2016 |
Drug Use Evaluation of Letrozole in Breast Cancer Patients at Regional Cancer Hospitals in Thailand.
Topics: Antineoplastic Agents; Breast Neoplasms; Cancer Care Facilities; Drug Utilization; Female; Follow-Up Studies; Humans; Letrozole; Middle Aged; Nitriles; Prognosis; Receptors, Estrogen; Retrospective Studies; Thailand; Triazoles | 2015 |
Insights into biology of luminal HER2 vs. enriched HER2 subtypes: Therapeutic implications.
Topics: Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Drug Resistance, Neoplasm; Female; Humans; Lapatinib; Letrozole; Molecular Imaging; Neoadjuvant Therapy; Nitriles; Precision Medicine; Quinazolines; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Trastuzumab; Triazoles | 2015 |
[Multiple smooth colon stenosis in 76-year-old female patient].
Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Diagnosis, Differential; Female; Humans; Intestinal Obstruction; Letrozole; Neoplasm Invasiveness; Nitriles; Treatment Outcome; Triazoles | 2015 |
Estrogen or anti-estrogen for Bologna poor responders?
Topics: Adult; Aromatase Inhibitors; Chorionic Gonadotropin; Embryo Transfer; Estradiol; Estrogens; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone; Humans; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Retrospective Studies; Treatment Outcome; Triazoles | 2015 |
Intermittent Letrozole Administration as Adjuvant Endocrine Therapy for Postmenopausal Women With Hormone Receptor-Positive Early Breast Cancer: A Biologic Study.
Topics: Aged; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Receptors, Estrogen; Triazoles | 2015 |
Endogenous oestrogens do not regulate endothelial nitric oxide production in early postnatal rats.
Topics: Animals; Animals, Newborn; Dose-Response Relationship, Drug; Endothelium, Vascular; Estrogens; Letrozole; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Nitriles; Organ Culture Techniques; Rats; Rats, Wistar; Triazoles | 2015 |
Ovarian granulosa cell tumour and letrozole: A case report.
Topics: Antineoplastic Agents; Fatal Outcome; Female; Granulosa Cell Tumor; Humans; Letrozole; Liver Neoplasms; Middle Aged; Nitriles; Ovarian Neoplasms; Peritoneal Neoplasms; Retreatment; Triazoles | 2016 |
Aromatase Inhibition and Capecitabine Combination as 1st or 2nd Line Treatment for Metastatic Breast Cancer - a Retrospective Analysis.
Topics: Adult; Aged; Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Capecitabine; Diarrhea; Disease Progression; Disease-Free Survival; Fatigue; Female; Follow-Up Studies; Hand-Foot Syndrome; Humans; Letrozole; Middle Aged; Nitriles; Receptors, Estrogen; Receptors, Progesterone; Retreatment; Retrospective Studies; Survival Rate; Triazoles | 2015 |
Reduced estradiol synthesis by letrozole, an aromatase inhibitor, is protective against development of pentylenetetrazole-induced kindling in mice.
Topics: Animals; Anticonvulsants; Aromatase Inhibitors; Convulsants; Dose-Response Relationship, Drug; Estradiol; Kindling, Neurologic; Letrozole; Male; Mice; Neurotransmitter Agents; Nitriles; Pentylenetetrazole; Triazoles | 2015 |
Everolimus in Metastatic Breast Cancer: Clinical Experience as a Late Treatment Line.
Topics: Adult; Aged; Aged, 80 and over; Androstadienes; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Case-Control Studies; Estradiol; Everolimus; Female; Follow-Up Studies; Fulvestrant; Humans; Letrozole; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Nitriles; Prognosis; Retrospective Studies; Survival Rate; Tamoxifen; Triazoles | 2015 |
Controlled ovarian hyperstimulation with sequential letrozole co-treatment in normo/high responders.
Topics: Adult; Aromatase Inhibitors; Chorionic Gonadotropin; Female; Gonadotropin-Releasing Hormone; Humans; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Reproductive Control Agents; Retrospective Studies; Sperm Injections, Intracytoplasmic; Triazoles | 2016 |
Long-Term Outcome of Aromatase Inhibitor Therapy With Letrozole in Patients With Advanced Low-Grade Endometrial Stromal Sarcoma.
Topics: Adult; Aromatase; Aromatase Inhibitors; Bone Density; Endometrial Neoplasms; Endometrial Stromal Tumors; Estradiol; Female; Humans; Letrozole; Middle Aged; Neoplasm, Residual; Nitriles; Receptors, Estrogen; Retreatment; Retrospective Studies; Treatment Outcome; Triazoles; Young Adult | 2015 |
Cloning, expression of, and evidence of positive selection for, the prolactin receptor gene in Chinese giant salamander (Andrias davidianus).
Topics: Animals; Evolution, Molecular; Female; Gene Expression Regulation, Developmental; Letrozole; Male; Methyltestosterone; Nitriles; Ovary; Phylogeny; Receptors, Prolactin; Testis; Triazoles; Urodela | 2015 |
Associations between genetic variants and the effect of letrozole and exemestane on bone mass and bone turnover.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers; Bone and Bones; Bone Density; Bone Remodeling; Breast Neoplasms; Female; Genetic Association Studies; Genetic Variation; Genotype; Humans; Letrozole; Middle Aged; Nitriles; Polymorphism, Single Nucleotide; Postmenopause; Triazoles | 2015 |
The Effects of Adjuvant Endocrine Treatment on Serum Leptin, Serum Adiponectin and Body Composition in Patients with Breast Cancer: The Izmir Oncology Group (IZOG) Study.
Topics: Adiponectin; Adult; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Body Composition; Body Mass Index; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Follow-Up Studies; Humans; Leptin; Letrozole; Middle Aged; Nitriles; Tamoxifen; Triazoles | 2016 |
Gene expression alterations associated with outcome in aromatase inhibitor-treated ER+ early-stage breast cancer patients.
Topics: Aged; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Chemotherapy, Adjuvant; Drug Resistance, Neoplasm; Eye Proteins; Female; Gene Expression Regulation, Neoplastic; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Peptides; Receptors, Estrogen; Retrospective Studies; RGS Proteins; Transcription Factors; Treatment Outcome; Trefoil Factor-3; Triazoles | 2015 |
Characterization and expression of cyp19a gene in the Chinese giant salamander Andrias davidianus.
Topics: Animals; Aromatase; Base Sequence; Cloning, Molecular; CpG Islands; DNA Methylation; Escherichia coli; Female; Gene Expression Regulation, Developmental; Insect Proteins; Letrozole; Male; Methyltestosterone; Molecular Sequence Data; Nitriles; Open Reading Frames; Organ Specificity; Ovary; Phylogeny; Promoter Regions, Genetic; Protein Sorting Signals; Recombinant Proteins; Sex Differentiation; Testis; Triazoles; Urodela | 2016 |
The impact of Anastrazole and Letrozole on the metabolic profile in an experimental animal model.
Topics: Anastrozole; Animals; Female; Letrozole; Lipid Metabolism; Liver; Nitriles; Rats; Rats, Wistar; Triazoles | 2015 |
Preparation and characterization of two new forced degradation products of letrozole and development of a stability-indicating RP-LC method for its determination.
Topics: Aromatase Inhibitors; Calibration; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Drug Contamination; Drug Stability; Hot Temperature; Humans; Hydrogen-Ion Concentration; Hydrolysis; Letrozole; Linear Models; Mass Spectrometry; Nitriles; Oxidation-Reduction; Photolysis; Reference Standards; Reproducibility of Results; Technology, Pharmaceutical; Triazoles | 2015 |
[Research of λ-cyhalothrin affect synaptic development in hippocampus by interfering with estrogen action].
Topics: Animals; Estradiol; Estrogens; Female; Hippocampus; Humans; Letrozole; Mice; Mice, Inbred ICR; Nitriles; Ovariectomy; Pyrethrins; Random Allocation; Synapses; Triazoles | 2015 |
Investigation on the interaction of letrozole with herring sperm DNA through spectroscopic and modeling methods.
Topics: Animals; Binding Sites; Circular Dichroism; DNA; Fishes; Letrozole; Male; Models, Molecular; Nitriles; Spectroscopy, Fourier Transform Infrared; Spermatozoa; Thermodynamics; Triazoles; Viscosity | 2016 |
A computational method for drug repositioning using publicly available gene expression data.
Topics: Antineoplastic Agents; Breast Neoplasms; Computational Biology; Databases, Genetic; Drug Repositioning; Female; Gene Expression Regulation, Neoplastic; Hepatitis C; Humans; Letrozole; Lung Neoplasms; Nitriles; Triazoles | 2015 |
Glyceollin I Reverses Epithelial to Mesenchymal Transition in Letrozole Resistant Breast Cancer through ZEB1.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Female; Humans; Letrozole; Mice; Mice, Nude; Nitriles; Pterocarpans; Transcription Factors; Triazoles | 2015 |
[Efficacies of aromatase inhibitors in the treatment of hormone dependent metastatic breast cancer in postmenopausal women: a report of 148 cases].
Topics: Anastrozole; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Disease-Free Survival; Female; Hormones; Humans; Letrozole; Neoplasm Metastasis; Nitriles; Postmenopause; Triazoles | 2015 |
The Gut Microbiome Is Altered in a Letrozole-Induced Mouse Model of Polycystic Ovary Syndrome.
Topics: Animals; Diet; Disease Models, Animal; Female; Gastrointestinal Microbiome; Letrozole; Mice; Nitriles; Polycystic Ovary Syndrome; Triazoles | 2016 |
Differential Expression of microRNAs in the Ovaries from Letrozole-Induced Rat Model of Polycystic Ovary Syndrome.
Topics: Animals; Biomarkers; Female; Gene Expression; Letrozole; MicroRNAs; Nitriles; Ovary; Polycystic Ovary Syndrome; Rats, Wistar; RNA Interference; Triazoles | 2016 |
Long-Term Safety of Letrozole and Gonadotropin Stimulation for Fertility Preservation in Women With Breast Cancer.
Topics: Adult; Aromatase Inhibitors; Breast Neoplasms; Case-Control Studies; Drug Therapy, Combination; Female; Fertility; Fertility Preservation; Gonadotropins; Humans; Letrozole; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Nitriles; Ovulation Induction; Prospective Studies; Survival Rate; Treatment Outcome; Triazoles | 2016 |
Letrozole vs estradiol valerate induced PCOS in rats: glycemic, oxidative and inflammatory status assessment.
Topics: Animals; Antioxidants; Blood Glucose; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Estradiol; Female; Glycemic Index; Inflammation; Letrozole; Nitriles; Oxidative Stress; Polycystic Ovary Syndrome; Rats; Rats, Wistar; Triazoles | 2016 |
miR-155 Drives Metabolic Reprogramming of ER+ Breast Cancer Cells Following Long-Term Estrogen Deprivation and Predicts Clinical Response to Aromatase Inhibitors.
Topics: Anastrozole; Animals; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Estrogens; Female; Glycolysis; Hexokinase; Humans; Letrozole; MCF-7 Cells; Mice; Mice, Nude; MicroRNAs; Neoadjuvant Therapy; Nitriles; Phosphorylation; Receptors, Estrogen; Triazoles | 2016 |
Invasive papillary carcinoma treated with neoadjuvant endocrine therapy in which pathological complete response was achieved.
Topics: Aged, 80 and over; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Carcinoma, Papillary; Female; Gene Expression; Humans; Letrozole; Neoadjuvant Therapy; Nitriles; Postmenopause; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Treatment Outcome; Triazoles | 2016 |
Tubal cytokine changes accompany the epithelial atypia of letrozole-stimulated ovaries.
Topics: Animals; Aromatase Inhibitors; Chemokine CCL2; Epithelium; Fallopian Tubes; Female; Interleukins; Letrozole; Nitriles; Ovary; Rats; Rats, Sprague-Dawley; Triazoles; Tumor Necrosis Factor-alpha | 2016 |
A global economic model to assess the cost-effectiveness of new treatments for advanced breast cancer in Canada.
Topics: Anastrozole; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Canada; Cost-Benefit Analysis; Disease Progression; Female; Health Services; Humans; Lapatinib; Letrozole; Markov Chains; Models, Econometric; Neoplasm Metastasis; Nitriles; Quality-Adjusted Life Years; Quinazolines; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Terminal Care; Trastuzumab; Triazoles | 2016 |
Inactivation of CYP2A6 by the Dietary Phenylpropanoid trans-Cinnamic Aldehyde (Cinnamaldehyde) and Estimation of Interactions with Nicotine and Letrozole.
Topics: Acrolein; Cytochrome P-450 CYP2A6; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; Letrozole; Microsomes, Liver; Nicotine; Nitriles; Triazoles | 2016 |
Self-renewal of CD133(hi) cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer.
Topics: AC133 Antigen; Anastrozole; Androstadienes; Animals; Antigens, CD; Antineoplastic Agents, Hormonal; Bone Neoplasms; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Cell Line, Tumor; Cell Self Renewal; Drug Resistance, Neoplasm; Estradiol; Female; Flow Cytometry; Fulvestrant; Gene Expression Regulation, Neoplastic; Glycoproteins; Humans; In Vitro Techniques; Interleukin-6; Letrozole; Leuprolide; MCF-7 Cells; Mice, Inbred NOD; Mice, SCID; Neoplasm Metastasis; Neoplasm Transplantation; Neoplastic Stem Cells; Nitriles; Oxidative Phosphorylation; Peptides; Real-Time Polymerase Chain Reaction; Receptor, Notch3; Receptors, Estrogen; Receptors, Notch; Signal Transduction; Tamoxifen; Triazoles | 2016 |
Synchronization of ovulation in cattle with an aromatase inhibitor-based protocol.
Topics: Administration, Intravaginal; Animals; Aromatase Inhibitors; Cattle; Cloprostenol; Corpus Luteum; Estradiol; Estrus Synchronization; Female; Gonadotropin-Releasing Hormone; Letrozole; Nitriles; Ovulation; Ovulation Detection; Progesterone; Random Allocation; Triazoles | 2016 |
Unilateral Internal Carotid Artery Occlusion After Letrozole Treatment in a Postmenopausal Woman with Breast Cancer.
Topics: Antineoplastic Agents; Arterial Occlusive Diseases; Breast Neoplasms; Carotid Artery Diseases; Carotid Artery, Internal; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Triazoles | 2016 |
Profile of Steroid Receptors and Increased Aromatase Immunoexpression in Canine Inflammatory Mammary Cancer as a Potential Therapeutic Target.
Topics: Animals; Antineoplastic Agents; Aromatase; Cell Line, Tumor; Cell Survival; Dog Diseases; Dogs; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Letrozole; Mammary Neoplasms, Animal; Nitriles; Receptors, Steroid; Triazoles | 2016 |
Assessing survival benefit when treatment delays disease progression.
Topics: Aromatase Inhibitors; Bayes Theorem; Breast Neoplasms; Chemotherapy, Adjuvant; Disease Progression; Disease-Free Survival; Female; Humans; Letrozole; Mastectomy; Neoplasm Staging; Nitriles; Proportional Hazards Models; Randomized Controlled Trials as Topic; Survival Rate; Triazoles | 2016 |
MicroRNA-206, let-7a and microRNA-21 pathways involved in the anti-angiogenesis effects of the interval exercise training and hormone therapy in breast cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Combined Modality Therapy; Exercise Therapy; Female; Letrozole; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; MicroRNAs; Muscle, Skeletal; Neovascularization, Pathologic; Nitriles; Signal Transduction; Tamoxifen; Triazoles | 2016 |
Luteal-phase ovarian stimulation is a feasible method for poor ovarian responders undergoing in vitro fertilization/intracytoplasmic sperm injection-embryo transfer treatment compared to a GnRH antagonist protocol: A retrospective study.
Topics: Adult; Clomiphene; Embryo Transfer; Feasibility Studies; Female; Fertility Agents, Female; Gonadotropin-Releasing Hormone; Hormone Antagonists; Humans; Letrozole; Luteal Phase; Menotropins; Nitriles; Oocyte Retrieval; Ovarian Follicle; Ovulation Induction; Pregnancy; Pregnancy Rate; Retrospective Studies; Sperm Injections, Intracytoplasmic; Triazoles | 2016 |
Comparison of Success of Clomiphene citrate and Letrozole in Ovulation Induction.
Topics: Adult; Bangladesh; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Prospective Studies; Triazoles; Young Adult | 2016 |
[Effects of compound malt pills on expressions of ERα and ERβ in ovaries of rats with letrozole-induced polycystic ovarian syndrome].
Topics: Animals; Corpus Luteum; Disease Models, Animal; Drugs, Chinese Herbal; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Granulosa Cells; Letrozole; Nitriles; Ovarian Follicle; Polycystic Ovary Syndrome; Rats; Rats, Sprague-Dawley; Triazoles | 2016 |
Role of oxidative stress and low-grade inflammation in letrozole-induced polycystic ovary syndrome in the rat.
Topics: Animals; Aromatase Inhibitors; C-Reactive Protein; Female; Gene Expression Regulation; Inflammation; Letrozole; Lipid Peroxidation; Nitriles; Ovarian Follicle; Oxidative Stress; Polycystic Ovary Syndrome; Rats; Receptor, Insulin; Superoxide Dismutase; Testosterone; Triazoles | 2016 |
Effect of Letrozole, a selective aromatase inhibitor, on testicular activities in adult mice: Both in vivo and in vitro study.
Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Aromatase Inhibitors; Cells, Cultured; Estradiol; Letrozole; Male; Mice; Nitriles; Reproduction; Spermatogenesis; Testis; Testosterone; Triazoles | 2017 |
Prognostic and predictive effects of diabetes, hypertension, and coronary artery disease among women on extended adjuvant letrozole: NCIC CTG MA.17.
Topics: Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Comorbidity; Coronary Artery Disease; Diabetes Mellitus; Disease Progression; Disease-Free Survival; Female; Humans; Hypertension; Letrozole; Lymphatic Metastasis; Middle Aged; Nitriles; Proportional Hazards Models; Randomized Controlled Trials as Topic; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Triazoles | 2016 |
Estrogen Regulation of Fetal Adrenal Cortical Zone-Specific Development in the Nonhuman Primate Impacts Adrenal Production of Androgen and Cortisol and Response to ACTH in Females in Adulthood.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Androgens; Animals; Aromatase Inhibitors; Dehydroepiandrosterone Sulfate; Estradiol; Female; Fetus; Hydrocortisone; Letrozole; Nitriles; Papio; Prolactin; Triazoles | 2016 |
The relationship of bone-tumor-induced spinal cord astrocyte activation and aromatase expression to mechanical hyperalgesia and cold hypersensitivity in intact female and ovariectomized mice.
Topics: Animals; Aromatase; Aromatase Inhibitors; Astrocytes; Bone Neoplasms; Cancer Pain; Cold Temperature; Estradiol; Estrogens; Female; Fibrosarcoma; Hyperalgesia; Letrozole; Mice, Inbred C3H; Neoplasm Transplantation; Nitriles; Nociception; Ovariectomy; Spinal Cord; Touch; Triazoles | 2016 |
Hyperuricemia in 2 Patients Receiving Palbociclib for Breast Cancer.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Disease-Free Survival; Female; Humans; Hyperuricemia; Letrozole; Nitriles; Piperazines; Protein Kinase Inhibitors; Pyridines; Receptor, ErbB-2; Receptors, Estrogen; Retrospective Studies; Triazoles | 2016 |
Aromatase inhibitors augment nociceptive behaviors in rats and enhance the excitability of sensory neurons.
Topics: Adenosine Triphosphate; Androstadienes; Animals; Aromatase Inhibitors; Calcitonin Gene-Related Peptide; Cells, Cultured; Disease Models, Animal; Female; Ganglia, Spinal; Hyperalgesia; Hypesthesia; Letrozole; Male; Membrane Potentials; Nitriles; Nociception; Ovariectomy; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Spinal Cord; Triazoles | 2016 |
Association between Polycystic Ovary Syndrome and Gut Microbiota.
Topics: Animals; Aromatase Inhibitors; Estrous Cycle; Female; Gastrointestinal Microbiome; Letrozole; Microbiota; Nitriles; Ovary; Polycystic Ovary Syndrome; Rats; Rats, Sprague-Dawley; Triazoles | 2016 |
CYR61 Confers the Sensitivity to Aromatase Inhibitor Letrozole in ER Positive Breast Carcinoma.
Topics: Aged; Aged, 80 and over; Aromatase Inhibitors; Breast Neoplasms; Cysteine-Rich Protein 61; Drug Resistance, Neoplasm; Female; Humans; Ki-67 Antigen; Letrozole; Middle Aged; Neoadjuvant Therapy; Nitriles; Receptors, Estrogen; Treatment Outcome; Triazoles | 2017 |
Comparison of ovarian stimulation response in patients with breast cancer undergoing ovarian stimulation with letrozole and gonadotropins to patients undergoing ovarian stimulation with gonadotropins alone for elective cryopreservation of oocytes†.
Topics: Adult; Antineoplastic Agents; Breast Neoplasms; Cryopreservation; Drug Therapy, Combination; Female; Fertility Preservation; Gonadotropins; Humans; Letrozole; Nitriles; Oocytes; Ovulation Induction; Treatment Outcome; Triazoles | 2016 |
Clinical Features of Male Breast Cancer: Experiences from Seven Institutions Over 20 Years.
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms, Male; Chemotherapy, Adjuvant; Female; Hormone Replacement Therapy; Humans; Letrozole; Male; Mastectomy; Middle Aged; Neoplasms, Second Primary; Nitriles; Prognosis; Receptor, ErbB-2; Republic of Korea; Tamoxifen; Trastuzumab; Treatment Outcome; Triazoles | 2016 |
Effect of letrozole in carcinogen-plus-estrogen-induced endometrial hyperplasia in mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Carcinogenesis; Endometrial Hyperplasia; Endometrial Neoplasms; Endometrium; Estradiol; Ethylnitrosourea; Female; Letrozole; Medroxyprogesterone Acetate; Mice, Inbred BALB C; Nitriles; Progesterone; Reproducibility of Results; Time Factors; Treatment Outcome; Triazoles | 2016 |
Twin delivery after IVF-ET with variable dose letrozole-FSH protocol of lower estradiol in a patient previously treated for breast cancer: a case report.
Topics: Adenocarcinoma, Mucinous; Adult; Aromatase Inhibitors; Breast Neoplasms; Embryo Transfer; Estradiol; Female; Fertility Agents, Female; Fertilization in Vitro; Follicle Stimulating Hormone; Humans; Infertility, Female; Letrozole; Menotropins; Nitriles; Ovulation Induction; Pregnancy; Pregnancy, Twin; Triazoles | 2016 |
Inhibition of local estrogen synthesis in the hippocampus impairs hippocampal memory consolidation in ovariectomized female mice.
Topics: Animals; Aromatase Inhibitors; Estradiol; Female; Hippocampus; Letrozole; Memory; Memory Consolidation; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Nitriles; Ovariectomy; Recognition, Psychology; Triazoles | 2016 |
Evaluating Markers for Guiding Treatment.
Topics: Age Factors; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Body Mass Index; Breast Neoplasms; Clinical Decision-Making; Decision Support Techniques; Disease-Free Survival; Female; Humans; Ki-67 Antigen; Letrozole; Logistic Models; Lymphatic Metastasis; Nitriles; Predictive Value of Tests; Randomized Controlled Trials as Topic; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles; Tumor Burden | 2016 |
Estrogen deprivation in primate pregnancy leads to insulin resistance in offspring.
Topics: Animals; Blood Glucose; Estradiol; Female; Fetal Development; Insulin; Insulin Resistance; Insulin Secretion; Letrozole; Nitriles; Papio anubis; Pregnancy; Prenatal Exposure Delayed Effects; Random Allocation; Receptor, Insulin; Triazoles | 2016 |
Effects of letrozole on breast cancer micro-metastatic tumor growth in bone and lung in mice inoculated with murine 4T1 cells.
Topics: Animals; Aromatase Inhibitors; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Letrozole; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Neoplasm Micrometastasis; Nitriles; Triazoles | 2016 |
Central leptin resistance and hypothalamic inflammation are involved in letrozole-induced polycystic ovary syndrome rats.
Topics: Animals; Body Weight; Eating; Female; Hypothalamus; Inflammation; Leptin; Letrozole; Nitriles; Ovary; Polycystic Ovary Syndrome; Rats, Sprague-Dawley; Suppressor of Cytokine Signaling 3 Protein; Triazoles | 2016 |
Letrozole-induced functional changes in carcinoma-associated fibroblasts and their influence on breast cancer cell biology.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Cells, Cultured; Coculture Techniques; Female; Fibroblasts; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Letrozole; MCF-7 Cells; Nitriles; Real-Time Polymerase Chain Reaction; Transcriptome; Triazoles | 2016 |
Complete response and long-term survival of leptomeningeal carcinomatosis from breast cancer with maintenance endocrine therapy.
Topics: Aged; Androstadienes; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Humans; Letrozole; Meningeal Carcinomatosis; Methotrexate; Nitriles; Spinal Neoplasms; Triazoles | 2016 |
The individual or combinational effects of Hesperetin and Letrozole on the activity and expression of aromatase in MCF-7 cells.
Topics: Aromatase; Cell Survival; Enzyme Assays; Estradiol; Hesperidin; Humans; Letrozole; MCF-7 Cells; Nitriles; Real-Time Polymerase Chain Reaction; Triazoles | 2016 |
Palbociclib as a first-line treatment in oestrogen receptor-positive, HER2-negative, advanced breast cancer not cost-effective with current pricing: a health economic analysis of the Swiss Group for Clinical Cancer Research (SAKK).
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Clinical Trials as Topic; Cost-Benefit Analysis; Disease-Free Survival; Female; Humans; Letrozole; Markov Chains; Nitriles; Piperazines; Pyridines; Quality-Adjusted Life Years; Receptor, ErbB-2; Receptors, Estrogen; Switzerland; Treatment Outcome; Triazoles | 2016 |
Differential profile of letrozole and exemestane on bone turnover markers in vinylcyclohexene diepoxide treated ovotoxic female mice.
Topics: Androstadienes; Animals; Aromatase Inhibitors; Biomarkers; Bone Density; Bone Remodeling; Carcinogens; Cyclohexenes; Estradiol; Female; Letrozole; Mice; Nitriles; Ovary; Triazoles; Vinyl Compounds | 2016 |
Prognostic Value of Intrinsic Subtypes in Hormone Receptor-Positive Metastatic Breast Cancer Treated With Letrozole With or Without Lapatinib.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bone Neoplasms; Breast Neoplasms; Disease-Free Survival; Female; Humans; Kaplan-Meier Estimate; Lapatinib; Letrozole; Middle Aged; Nitriles; Prognosis; Proportional Hazards Models; Quinazolines; Receptor, ErbB-2; Retrospective Studies; Treatment Outcome; Triazoles | 2016 |
Aromatase inhibitor regulates let-7 expression and let-7f-induced cell migration in endometrial cells from women with endometriosis.
Topics: Aromatase; Aromatase Inhibitors; Cell Line; Cell Movement; Dose-Response Relationship, Drug; Endometriosis; Endometrium; Estradiol; Female; Humans; Laparoscopy; Letrozole; MicroRNAs; Nitriles; Signal Transduction; Stromal Cells; Time Factors; Transfection; Triazoles | 2016 |
Aromatase inhibitors decrease radiation-induced lung fibrosis: Results of an experimental study.
Topics: Anastrozole; Androstadienes; Animals; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Chemotherapy, Adjuvant; Female; Letrozole; Nitriles; Pulmonary Fibrosis; Radiation Injuries, Experimental; Radiotherapy; Rats; Rats, Wistar; Tamoxifen; Triazoles | 2016 |
Treatment with aromatase inhibitors stimulates the expression of epidermal growth factor receptor-1 and neuregulin 1 in ER positive/HER-2/neu non-amplified primary breast cancers.
Topics: Anastrozole; Aromatase Inhibitors; Breast Neoplasms; DNA Mutational Analysis; Drug Administration Schedule; ErbB Receptors; Estrogen Receptor alpha; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Letrozole; Mutation; Neuregulin-1; Nitriles; Receptor, ErbB-2; RNA, Messenger; Treatment Outcome; Triazoles | 2017 |
Circulating oxysterol metabolites as potential new surrogate markers in patients with hormone receptor-positive breast cancer: Results of the OXYTAM study.
Topics: Adult; Aged; Androstadienes; Aromatase; Aromatase Inhibitors; Biomarkers; Body Mass Index; Breast Neoplasms; Cholestanes; Cholesterol; Feasibility Studies; Female; Gas Chromatography-Mass Spectrometry; Hormones; Humans; Letrozole; Middle Aged; Neoplasm Metastasis; Nitriles; Oxidative Stress; Oxysterols; Pilot Projects; Prognosis; Prospective Studies; Reproducibility of Results; Signal Transduction; Tamoxifen; Triazoles | 2017 |
Effects of Exercise Intervention on Preventing Letrozole-Exposed Rats From Polycystic Ovary Syndrome.
Topics: Animals; Aromatase Inhibitors; Body Weight; Disease Models, Animal; Female; Follicle Stimulating Hormone; Insulin; Leptin; Letrozole; Nitriles; Obesity; Physical Conditioning, Animal; Polycystic Ovary Syndrome; Progesterone; Rats; Testosterone; Triazoles | 2017 |
Diagnosis and Treatment of Polycystic Ovary Syndrome.
Topics: Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Female; Humans; Hyperandrogenism; Hypoglycemic Agents; Infertility, Female; Letrozole; Metformin; Nitriles; Overweight; Polycystic Ovary Syndrome; Triazoles; Weight Loss | 2016 |
Effects of cisplatin and letrozole on surgically induced endometriosis and comparison of the two medications in a rat model.
Topics: Animals; Cisplatin; Disease Models, Animal; Endometriosis; Female; Letrozole; Nitriles; Rats; Triazoles | 2016 |
A comparison among different methods of letrozole combined with gonadotropin in an antagonist protocol and high-dose gonadotropin ovarian stimulation antagonist protocol in poor ovarian responders undergoing in vitro fertilization.
Topics: Adult; Antineoplastic Agents; Birth Rate; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone; Humans; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Outcome; Triazoles; Young Adult | 2016 |
Clinical and endocrine characteristics and genetic analysis of Korean children with McCune-Albright syndrome: a retrospective cohort study.
Topics: Acromegaly; Adolescent; Cafe-au-Lait Spots; Child; Child, Preschool; Chromogranins; Female; Fibrous Dysplasia, Polyostotic; Genetic Testing; GTP-Binding Protein alpha Subunits, Gs; Humans; Infant; Letrozole; Male; Mutation; Nitriles; Pituitary Neoplasms; Polymerase Chain Reaction; Puberty, Precocious; Republic of Korea; Retrospective Studies; Triazoles | 2016 |
Sexually Dimorphic Expression of Foxl2 and Ftz-F1 in Chinese Giant Salamander Andrias Davidianus.
Topics: Amino Acid Sequence; Animals; Female; Gene Expression Regulation, Developmental; Letrozole; Male; Methyltestosterone; Nitriles; Organ Specificity; Ovary; Receptors, Cytoplasmic and Nuclear; Sequence Homology, Amino Acid; Sex Differentiation; Testis; Transcription Factors; Triazoles; Urodela | 2016 |
Fluorometric Investigation on the Binding of Letrozole and Resveratrol with Serum Albumin.
Topics: Aromatase Inhibitors; Fluorometry; Humans; Letrozole; Nitriles; Protein Binding; Resveratrol; Serum Albumin; Spectrometry, Fluorescence; Stilbenes; Triazoles | 2016 |
Efficacy of Letrozole as First-Line Treatment of Postmenopausal Women with Hormone Receptor-Positive Metastatic Breast Cancer in Korea.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Letrozole; Middle Aged; Neoplasm Metastasis; Nitriles; Postmenopause; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Republic of Korea; Survival Analysis; Treatment Outcome; Triazoles | 2017 |
Long-term outcomes of letrozole treatment for precocious puberty in girls with McCune-Albright syndrome.
Topics: Aromatase Inhibitors; Body Height; Child; Child, Preschool; Cohort Studies; Drug Administration Schedule; Female; Fibrous Dysplasia, Polyostotic; Humans; Infant; Letrozole; Nitriles; Pilot Projects; Puberty, Precocious; Retrospective Studies; Time Factors; Treatment Outcome; Triazoles | 2016 |
Reversal of tubo-ovarian atypical epithelial patterns after cessation of ovarian stimulation by letrozole.
Topics: Animals; Aromatase Inhibitors; Cell Proliferation; Chemokine CCL2; Cytokines; Epithelial Cells; Epithelium; Fallopian Tubes; Female; Letrozole; Nitriles; Ovary; Ovulation Induction; Rats, Sprague-Dawley; Triazoles; Withholding Treatment | 2016 |
Targeting the receptor tyrosine kinase RET in combination with aromatase inhibitors in ER positive breast cancer xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Carbanilides; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Humans; Letrozole; MCF-7 Cells; Mice, Nude; Molecular Targeted Therapy; Neoplasm Invasiveness; Nitriles; Ovariectomy; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-ret; Receptors, Estrogen; Signal Transduction; Spheroids, Cellular; Time Factors; Transfection; Triazoles; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
The impact of ovarian stimulation on the outcome of intrauterine insemination treatment: an analysis of 8893 cycles.
Topics: China; Clomiphene; Female; Fertilization in Vitro; Humans; Insemination, Artificial; Letrozole; Live Birth; Luteal Phase; Nitriles; Ovarian Hyperstimulation Syndrome; Ovulation Induction; Pregnancy; Pregnancy Rate; Pregnancy, Twin; Reproductive Medicine; Retrospective Studies; Treatment Outcome; Triazoles | 2016 |
Interest in Integrative Medicine Among Postmenopausal Hormone Receptor-Positive Breast Cancer Patients in the EvAluate-TM Study.
Topics: Aged; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Female; Germany; Humans; Integrative Medicine; Letrozole; Middle Aged; Nitriles; Postmenopause; Prospective Studies; Triazoles | 2017 |
Kisspeptin mRNA expression is increased in the posterior hypothalamus in the rat model of polycystic ovary syndrome.
Topics: Animals; Disease Models, Animal; Female; Gene Expression Regulation; Humans; Hypothalamus, Posterior; Kisspeptins; Letrozole; Nitriles; Polycystic Ovary Syndrome; Rats; Rats, Wistar; RNA, Messenger; Triazoles; Up-Regulation | 2017 |
Insulin resistance elicited in postpubertal primate offspring deprived of estrogen in utero.
Topics: Animals; Aromatase Inhibitors; Estradiol; Female; Glucose Tolerance Test; Insulin Resistance; Letrozole; Nitriles; Papio anubis; Pregnancy; Prenatal Exposure Delayed Effects; Sexual Maturation; Triazoles | 2016 |
Altered expression of miRNAs in the uterus from a letrozole-induced rat PCOS model.
Topics: Animals; Disease Models, Animal; Estrus; Female; Gene Expression; Humans; Letrozole; MicroRNAs; Nitriles; Ovary; Polycystic Ovary Syndrome; Pregnancy; Rats; Rats, Wistar; Signal Transduction; Triazoles; Uterus | 2017 |
Estrogen Suppresses Interaction of Melanocortin 2 Receptor and Its Accessory Protein in the Primate Fetal Adrenal Cortex.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Aromatase Inhibitors; Estradiol; Female; Letrozole; Nitriles; Papio; Pituitary Gland; Pro-Opiomelanocortin; Receptor, Melanocortin, Type 2; Triazoles | 2016 |
Acupuncture does not ameliorate metabolic disturbances in the P450 aromatase inhibitor-induced rat model of polycystic ovary syndrome.
Topics: Acupuncture Therapy; Adipose Tissue; Animals; Aromatase; Aromatase Inhibitors; Cytochrome P-450 Enzyme System; Disease Models, Animal; Down-Regulation; Electroacupuncture; Female; Insulin Resistance; Letrozole; Lipoproteins, LDL; Locomotion; Nitriles; Polycystic Ovary Syndrome; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Triazoles; Up-Regulation | 2017 |
Different synaptic stimulation patterns influence the local androgenic and estrogenic neurosteroid availability triggering hippocampal synaptic plasticity in the male rat.
Topics: 5-alpha Reductase Inhibitors; Animals; Aromatase Inhibitors; Estradiol; Finasteride; Hippocampus; Letrozole; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Nitriles; Rats; Rats, Wistar; Synaptic Potentials; Testosterone; Triazoles | 2017 |
Ribociclib Lengthens Breast Cancer Survival.
Topics: Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Clinical Trials as Topic; Disease-Free Survival; Female; Humans; Letrozole; Nitriles; Purines; Treatment Outcome; Triazoles | 2016 |
No increased risk of major congenital anomalies or adverse pregnancy or neonatal outcomes following letrozole use in assisted reproductive technology.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Aromatase Inhibitors; Female; Fertilization in Vitro; Humans; Infant, Newborn; Letrozole; Maternal Age; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Outcome; Retrospective Studies; Risk; Triazoles | 2017 |
Effects of raloxifene against letrozole-induced bone loss in chemically-induced model of menopause in mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Biomarkers; Bone Remodeling; Bone Resorption; Cyclohexenes; Female; Femur; Glycoproteins; Intercellular Signaling Peptides and Proteins; Letrozole; Lumbar Vertebrae; Menopause; Mice; Nitriles; Raloxifene Hydrochloride; Triazoles; Vinyl Compounds | 2017 |
Clomiphene Citrate versus Letrozole for Ovarian Stimulation in Therapeutic Donor Sperm Insemination.
Topics: Adult; Aromatase Inhibitors; Canada; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Male; Insemination, Artificial, Heterologous; Letrozole; Live Birth; Male; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Outcome; Pregnancy Rate; Retrospective Studies; Tissue Donors; Triazoles | 2017 |
Synaptopodin is regulated by aromatase activity.
Topics: Animals; Aromatase; Aromatase Inhibitors; Calcium Signaling; Cells, Cultured; Enzyme Activation; Female; Hippocampus; Letrozole; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Nitriles; Rats; Rats, Wistar; Triazoles | 2017 |
Enhancing Endocrine Therapy Combination Strategies for the Treatment of Postmenopausal HR+/HER2- Advanced Breast Cancer.
Topics: Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Circulating Tumor DNA; Disease-Free Survival; Estradiol; Female; Fulvestrant; Humans; Letrozole; Mutation; Neoplastic Cells, Circulating; Nitriles; Nuclear Proteins; Piperazines; Postmenopause; Pyridines; Receptor, ErbB-2; Receptors, Estrogen; Transcription Factors; Triazoles | 2017 |
Palbociclib improves survival in advanced breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase III as Topic; Disease Progression; Disease-Free Survival; Female; Humans; Letrozole; Nitriles; Piperazines; Protein Kinase Inhibitors; Pyridines; Randomized Controlled Trials as Topic; Risk Factors; Time Factors; Treatment Outcome; Triazoles | 2017 |
Differential Effects of Testosterone and Estradiol on Clitoral Function: An Experimental Study in Rats.
Topics: Amides; Animals; Clitoris; Cyclic GMP; Estradiol; Female; Letrozole; Muscle, Smooth; Nitric Oxide; Nitriles; Ovariectomy; Pyridines; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Testosterone; Triazoles | 2016 |
Ameliorative effects of rutin against metabolic, biochemical and hormonal disturbances in polycystic ovary syndrome in rats.
Topics: Animals; Antioxidants; Aromatase Inhibitors; Biomarkers; Blood Glucose; Body Weights and Measures; C-Reactive Protein; Disease Models, Animal; Estrous Cycle; Female; Gonadal Hormones; Letrozole; Lipids; Metformin; Nitriles; Ovary; Oxidative Stress; Polycystic Ovary Syndrome; Rats; Reactive Oxygen Species; Rutin; Triazoles | 2016 |
Soy isoflavones exert beneficial effects on letrozole-induced rat polycystic ovary syndrome (PCOS) model through anti-androgenic mechanism.
Topics: 17-Hydroxysteroid Dehydrogenases; 3-Hydroxysteroid Dehydrogenases; Androgen Antagonists; Animals; Antioxidants; Biomarkers; Blood Glucose; Cholesterol; Disease Models, Animal; Dose-Response Relationship, Drug; Estradiol; Estrous Cycle; Female; Glycine max; Isoflavones; Letrozole; Nitriles; Ovary; Oxidative Stress; Phytoestrogens; Phytotherapy; Plants, Medicinal; Polycystic Ovary Syndrome; Rats, Sprague-Dawley; Testosterone; Time Factors; Triazoles; Uterus; Weight Gain | 2017 |
The Effect of Undaria pinnatifida Fucoidan on the Pharmacokinetics of Letrozole and Tamoxifen in Patients With Breast Cancer.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Female; Herb-Drug Interactions; Humans; Letrozole; Middle Aged; Nitriles; Phytotherapy; Polysaccharides; Tamoxifen; Triazoles; Undaria | 2018 |
Sex-Dependent Regulation of Aromatase-Mediated Synaptic Plasticity in the Basolateral Amygdala.
Topics: Animals; Aromatase; Aromatase Inhibitors; Basolateral Nuclear Complex; Excitatory Postsynaptic Potentials; Female; Letrozole; Male; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Nitriles; Organ Culture Techniques; Rats; Sex Characteristics; Triazoles | 2017 |
Aromatase inhibitor-induced bone loss increases the progression of estrogen receptor-negative breast cancer in bone and exacerbates muscle weakness in vivo.
Topics: Animals; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Bone Density; Bone Density Conservation Agents; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Diphosphonates; Disease Progression; Estradiol; Female; Humans; Imidazoles; Letrozole; Mice, Inbred BALB C; Mice, Nude; Muscle Strength; Muscle Weakness; Muscle, Skeletal; Nitriles; Osteolysis; Ovariectomy; Receptors, Estrogen; Time Factors; Triazoles; Tumor Burden; Tumor Microenvironment; Xenograft Model Antitumor Assays; Zoledronic Acid | 2017 |
18F-FDG PET/CT in the Staging and Management of Breast Cancer: Value in Disease Outcome and Planning Therapy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Axilla; Bone Density Conservation Agents; Bone Neoplasms; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Diphosphonates; Docetaxel; Epirubicin; Female; Fluorodeoxyglucose F18; Fluorouracil; Gonadotropin-Releasing Hormone; Humans; Imidazoles; Letrozole; Lymph Node Excision; Lymph Nodes; Mastectomy; Multimodal Imaging; Neoadjuvant Therapy; Neoplasm Staging; Nitriles; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals; Radiotherapy; Ribs; Taxoids; Triazoles; Zoledronic Acid | 2017 |
Magnetic iron oxide nanoparticles grafted N-isopropylacrylamide/chitosan copolymer for the extraction and determination of letrozole in human biological samples.
Topics: Acrylamides; Chitosan; Ferric Compounds; Humans; Hydrogen-Ion Concentration; Letrozole; Magnetite Nanoparticles; Nitriles; Solid Phase Extraction; Spectroscopy, Fourier Transform Infrared; Triazoles | 2017 |
Novel amphiphilic chitosan nanocarriers for sustained oral delivery of hydrophobic drugs.
Topics: Administration, Oral; Biological Availability; Cell Line, Tumor; Chitosan; Delayed-Action Preparations; Drug Carriers; Drug Liberation; Emulsions; Gels; Humans; Hydrophobic and Hydrophilic Interactions; Letrozole; MCF-7 Cells; Nanoparticles; Nitriles; Particle Size; Polyphosphates; Spectroscopy, Fourier Transform Infrared; Triazoles; X-Ray Diffraction | 2017 |
Prenatal administration of letrozole reduces SDN and SCN volume and cell number independent of partner preference in the male rat.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Cell Count; Female; Letrozole; Male; Mating Preference, Animal; Nitriles; Pregnancy; Prenatal Exposure Delayed Effects; Preoptic Area; Rats; Sex Differentiation; Sexual Partners; Suprachiasmatic Nucleus; Triazoles; Vasopressins | 2017 |
[A Case of Interstitial Pneumonitis Induced by Lapatinib plus Letrozole].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Ductal, Breast; ErbB Receptors; Female; Humans; Lapatinib; Letrozole; Lung Diseases, Interstitial; Nitriles; Quinazolines; Triazoles | 2016 |
[Two Cases of Lung Metastasis from Breast Cancer Successfully Treated with Endocrine Therapy].
Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Estradiol; Estrogen Receptor Antagonists; Female; Fulvestrant; Humans; Letrozole; Lung Neoplasms; Nitriles; Treatment Outcome; Triazoles | 2016 |
Letrozole not superior to anastrozole for early breast cancer.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Prognosis; Triazoles | 2017 |
GnRH antagonist and letrozole co-treatment in diminished ovarian reserve patients: a proof-of-concept study.
Topics: Adult; Aromatase Inhibitors; Drug Therapy, Combination; Estradiol; Female; Fertility Agents, Female; Fertilization in Vitro; Follicle Stimulating Hormone, Human; Gonadotropin-Releasing Hormone; Humans; Infertility, Female; Letrozole; Luteal Phase; Nitriles; Oogenesis; Ovarian Follicle; Ovarian Reserve; Ovulation Induction; Pregnancy; Pregnancy Rate; Primary Ovarian Insufficiency; Recombinant Proteins; Retrospective Studies; Triazoles; Turkey | 2017 |
Comparison of the effects of nobiletin and letrozole on the activity and expression of aromatase in the MCF-7 breast cancer cell line.
Topics: Aromatase; Breast Neoplasms; Cell Survival; Dose-Response Relationship, Drug; Flavones; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Letrozole; MCF-7 Cells; Nitriles; Structure-Activity Relationship; Triazoles | 2017 |
Anti-GD2-ch14.18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patient-derived GBM tumor cells.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Aromatase Inhibitors; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gangliosides; Glioblastoma; HeLa Cells; Humans; Immunotoxins; Lactic Acid; Letrozole; Nanoparticles; Nitriles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Transfection; Triazoles | 2017 |
Fabrication of letrozole formulation using chitosan nanoparticles through ionic gelation method.
Topics: Biocompatible Materials; Chitosan; Drug Carriers; Drug Compounding; Drug Liberation; Drug Stability; Humans; Hydrogen Bonding; Ions; Kinetics; Letrozole; Materials Testing; Molecular Structure; Nanoparticles; Nitriles; Spectroscopy, Fourier Transform Infrared; Thermogravimetry; Triazoles; X-Ray Diffraction | 2017 |
A retrospective analysis of ovarian stimulation with letrozole in women undergoing artificial insemination by donor.
Topics: Aromatase Inhibitors; Estradiol; Female; Gonadotropins; Humans; Insemination, Artificial, Heterologous; Letrozole; Logistic Models; Nitriles; Ovarian Follicle; Ovulation Induction; Pregnancy; Pregnancy Rate; Retrospective Studies; Triazoles | 2017 |
Subcutaneous testosterone-letrozole therapy before and concurrent with neoadjuvant breast chemotherapy: clinical response and therapeutic implications.
Topics: Androgens; Antineoplastic Combined Chemotherapy Protocols; Breast Implants; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Humans; Letrozole; Middle Aged; Neoadjuvant Therapy; Nitriles; Testosterone; Treatment Outcome; Triazoles; Tumor Burden | 2017 |
Alleviation of ischaemia-reperfusion injury by endogenous estrogen involves maintaining Bcl-2 expression via the ERα signalling pathway.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Estradiol; Estrogen Receptor alpha; Estrogens; Estrous Cycle; Female; Genes, bcl-2; Infarction, Middle Cerebral Artery; Letrozole; Neurons; Neuroprotective Agents; Nitriles; Ovariectomy; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Triazoles | 2017 |
Hormonal Maintenance Therapy for Women With Low-Grade Serous Cancer of the Ovary or Peritoneum.
Topics: Adult; Aged; Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Cytoreduction Surgical Procedures; Disease Progression; Disease-Free Survival; Female; Follow-Up Studies; Humans; Letrozole; Leuprolide; Maintenance Chemotherapy; Medroxyprogesterone Acetate; Middle Aged; Neoplasm Grading; Neoplasm Staging; Neoplasms, Cystic, Mucinous, and Serous; Nitriles; Ovarian Neoplasms; Peritoneal Neoplasms; Platinum Compounds; Survival Rate; Tamoxifen; Triazoles; Watchful Waiting; Young Adult | 2017 |
Redox and pH Responsive Poly (Amidoamine) Dendrimer-Heparin Conjugates via Disulfide Linkages for Letrozole Delivery.
Topics: Dendrimers; Disulfides; Drug Delivery Systems; Drug Liberation; Dynamic Light Scattering; Heparin; Hydrogen-Ion Concentration; Letrozole; Microscopy, Electron, Transmission; Nitriles; Oxidation-Reduction; Particle Size; Polyamines; Proton Magnetic Resonance Spectroscopy; Static Electricity; Triazoles | 2017 |
Cognition in female rats after blocking conversion of androgens to estrogens.
Topics: Androgens; Animals; Aromatase Inhibitors; Cognition; Estradiol; Estrogens; Female; Letrozole; Maze Learning; Nitriles; Rats; Rats, Long-Evans; Testosterone; Triazoles; Uterus | 2017 |
Liver Resection for Breast Cancer Liver Metastases: A Cost-utility Analysis.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cost-Benefit Analysis; Disease-Free Survival; Docetaxel; Female; Hepatectomy; Humans; Letrozole; Liver Neoplasms; Male; Markov Chains; Neoplasm Invasiveness; Neoplasm Staging; Nitriles; Piperazines; Pyridines; Quality-Adjusted Life Years; Survival Rate; Taxoids; Triazoles | 2017 |
Mild versus conventional antagonist ovarian stimulation protocols in expected normal responders undergoing IVF/ICSI: a case-control study.
Topics: Adult; Case-Control Studies; Clomiphene; Female; Fertility Agents, Female; Fertilization in Vitro; Humans; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Sperm Injections, Intracytoplasmic; Treatment Outcome; Triazoles; Young Adult | 2017 |
Letrozole combined with low dose highly purified HMG for ovulation induction in clomiphene citrate-resistant infertile Chinese women with polycystic ovary syndrome: a prospective study.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Female; Humans; Letrozole; Menotropins; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Prospective Studies; Triazoles | 2017 |
The role of nesfatin-1 expression in letrozole-induced polycystic ovaries in the rat.
Topics: Animals; Calcium-Binding Proteins; Disease Models, Animal; DNA-Binding Proteins; Female; Letrozole; Nerve Tissue Proteins; Nitriles; Nucleobindins; Ovary; Polycystic Ovary Syndrome; Random Allocation; Rats, Sprague-Dawley; Triazoles | 2017 |
Tumor-infiltrating lymphocytes and molecular response after neoadjuvant therapy for HR+/HER2- breast cancer: results from two prospective trials.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Lapatinib; Letrozole; Lymphocytes, Tumor-Infiltrating; Middle Aged; Neoadjuvant Therapy; Nitriles; Prospective Studies; Quinazolines; Receptor, ErbB-2; Receptors, Cell Surface; Treatment Outcome; Triazoles | 2017 |
Estimating efficacy in trials with selective crossover.
Topics: Antineoplastic Agents; Binomial Distribution; Biostatistics; Breast Neoplasms; Clinical Trials as Topic; Computer Simulation; Cross-Over Studies; Disease-Free Survival; Female; Humans; Letrozole; Likelihood Functions; Models, Statistical; Nitriles; Proportional Hazards Models; Randomized Controlled Trials as Topic; Tamoxifen; Treatment Outcome; Triazoles | 2017 |
Cost-effectiveness of palbociclib plus letrozole versus letrozole alone as a first-line treatment in women with oestrogen receptor-positive, HER2-negative, advanced breast cancer. Revised results for the Swiss health care setting.
Topics: Breast Neoplasms; Cost-Benefit Analysis; Female; Humans; Letrozole; Nitriles; Piperazines; Pyridines; Receptors, Estrogen; Triazoles | 2017 |
Gonadotropin-Inhibitory Hormone, the Piscine Ortholog of LPXRFa, Participates in 17β-Estradiol Feedback in Female Goldfish Reproduction.
Topics: Animals; Aromatase Inhibitors; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Feedback, Physiological; Female; Goldfish; Hypothalamic Hormones; Hypothalamus; Letrozole; Neurons; Nitriles; Ovariectomy; Reproduction; Triazoles | 2017 |
Exercise differentially affects metabolic functions and white adipose tissue in female letrozole- and dihydrotestosterone-induced mouse models of polycystic ovary syndrome.
Topics: Adipocytes; Adipogenesis; Adipose Tissue, White; Animals; Body Composition; Body Weight; Cell Size; Dihydrotestosterone; Disease Models, Animal; Feeding Behavior; Female; Gene Expression Regulation; Glucose Tolerance Test; Insulin Resistance; Letrozole; Lipid Metabolism; Liver; Mice, Inbred C57BL; Nitriles; Organ Size; Phenotype; Physical Conditioning, Animal; Polycystic Ovary Syndrome; Signal Transduction; Triazoles; Triglycerides | 2017 |
Melasma treatment: A novel approach using a topical agent that contains an anti-estrogen and a vascular endothelial growth factor inhibitor.
Topics: Administration, Topical; Anastrozole; Androstadienes; Aromatase Inhibitors; Estrogens; Female; Genetic Predisposition to Disease; Humans; Hyperpigmentation; Letrozole; Male; Melanosis; Neovascularization, Pathologic; Nitriles; Pregnancy; Raloxifene Hydrochloride; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles; Ultraviolet Rays; Vascular Endothelial Growth Factor A | 2017 |
The effects of Nobiletin, Hesperetin, and Letrozole in a combination on the activity and expression of aromatase in breast cancer cells.
Topics: Aromatase; Aromatase Inhibitors; Estradiol; Flavones; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Hesperidin; Humans; Immunoassay; Letrozole; MCF-7 Cells; Nitriles; Reverse Transcriptase Polymerase Chain Reaction; Triazoles | 2017 |
Pregnancy and neonatal outcomes following letrozole use in frozen-thawed single embryo transfer cycles.
Topics: Abortion, Spontaneous; Aromatase Inhibitors; Blastocyst; Cohort Studies; Cryopreservation; Female; Fertility Agents, Female; Hormone Replacement Therapy; Humans; Infant, Newborn; Infertility, Female; Japan; Letrozole; Live Birth; Male; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Registries; Retrospective Studies; Risk; Single Embryo Transfer; Triazoles | 2017 |
Durable complete remission with aromatase inhibitor therapy in a patient with metastatic uterine carcinosarcoma with poor performance status and coagulation disorders: a case report.
Topics: Aromatase Inhibitors; Blood Coagulation Disorders; Bone Neoplasms; Carcinosarcoma; Female; Humans; Letrozole; Lymphatic Metastasis; Middle Aged; Nitriles; Remission Induction; Shock; Triazoles; Uterine Hemorrhage; Uterine Neoplasms | 2017 |
The prognostic significance of Cdc6 and Cdt1 in breast cancer.
Topics: Animals; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; DNA Replication; Female; Gene Expression Regulation, Neoplastic; Humans; Letrozole; MCF-7 Cells; Mice; Nitriles; Nuclear Proteins; Prognosis; RAW 264.7 Cells; Receptors, Estrogen; Survival Analysis; Tamoxifen; Triazoles; Up-Regulation | 2017 |
Evaluation of Active Hexose Correlated Compound (AHCC) in Combination With Anticancer Hormones in Orthotopic Breast Cancer Models.
Topics: Animals; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Estradiol; Estrogen Antagonists; Female; Humans; Letrozole; MCF-7 Cells; Mice; Nitriles; Polysaccharides; Tamoxifen; Triazoles | 2017 |
Fulvestrant plus LHRH analogues in male with synchronous breast and prostate cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms, Male; Estradiol; Fulvestrant; Gonadotropin-Releasing Hormone; Humans; Letrozole; Male; Neoplasms, Multiple Primary; Nitriles; Prostatic Neoplasms; Tamoxifen; Triazoles | 2017 |
Micturition dysfunction in four-month old ovariectomized rats: Effects of testosterone replacement.
Topics: Acetanilides; Androgens; Angiotensin II; Animals; Carbachol; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Injections, Intramuscular; Letrozole; Muscle, Smooth; Nitriles; Ovariectomy; Postmenopause; Rats; Rats, Sprague-Dawley; Testosterone; Thiazoles; Triazoles; Urethra; Urination Disorders | 2017 |
Gonadotropin-Releasing Hormone Agonist Combined With a Levonorgestrel-Releasing Intrauterine System or Letrozole for Fertility-Preserving Treatment of Endometrial Carcinoma and Complex Atypical Hyperplasia in Young Women.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Carcinoma, Endometrioid; Endometrial Hyperplasia; Endometrial Neoplasms; Female; Fertility Preservation; Gonadotropin-Releasing Hormone; Humans; Intrauterine Devices, Medicated; Letrozole; Levonorgestrel; Nitriles; Retrospective Studies; Triazoles; Young Adult | 2017 |
Letrozole, an aromatase inhibitor, reduces post-peak age-related regression of rooster reproductive performance.
Topics: Aging; Animals; Chickens; Infertility, Male; Insemination, Artificial; Letrozole; Lipid Peroxidation; Male; Nitriles; Triazoles | 2017 |
The promising effect of linagliptin and/or indole-3-carbinol on experimentally-induced polycystic ovarian syndrome.
Topics: Administration, Oral; Animals; Female; Indoles; Letrozole; Linagliptin; Nitriles; Polycystic Ovary Syndrome; Rats; Rats, Wistar; Triazoles | 2017 |
Multi-Reservoir Phospholipid Shell Encapsulating Protamine Nanocapsules for Co-Delivery of Letrozole and Celecoxib in Breast Cancer Therapy.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Celecoxib; Drug Carriers; Drug Combinations; Female; Humans; Letrozole; MCF-7 Cells; Mice, Inbred BALB C; Nanocapsules; Nitriles; Phospholipids; Protamines; Rats, Sprague-Dawley; Triazoles | 2017 |
Inhibition of 17beta-hydroxysteroid dehydrogenase type 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78.
Topics: 17-Hydroxysteroid Dehydrogenases; Antineoplastic Agents; Apoptosis; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Drug Synergism; Endoplasmic Reticulum Chaperone BiP; Enzyme Inhibitors; Epithelial Cells; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Heat-Shock Proteins; Humans; Letrozole; Molecular Sequence Annotation; Nitriles; Organ Specificity; Postmenopause; Protein Interaction Mapping; Proto-Oncogene Proteins c-bcl-2; Receptors, G-Protein-Coupled; RNA, Small Interfering; Signal Transduction; Triazoles | 2017 |
A successful live birth with in vitro fertilization and thawed embryo transfer after conservative treatment of recurrent endometrial cancer.
Topics: Adult; Antineoplastic Agents, Hormonal; Conservative Treatment; Cryopreservation; Embryo Transfer; Endometrial Neoplasms; Female; Fertility Preservation; Fertilization in Vitro; Humans; Letrozole; Levonorgestrel; Live Birth; Megestrol Acetate; Neoplasm Recurrence, Local; Nitriles; Pregnancy; Pregnancy Outcome; Triazoles | 2018 |
Different patterns in the risk of newly developed fatty liver and lipid changes with tamoxifen versus aromatase inhibitors in postmenopausal women with early breast cancer: A propensity score-matched cohort study.
Topics: Adult; Aged; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers; Breast Neoplasms; Chemotherapy, Adjuvant; Fatty Liver; Female; Humans; Incidence; Letrozole; Lipids; Middle Aged; Nitriles; Propensity Score; Retrospective Studies; Tamoxifen; Triazoles | 2017 |
Molecular mechanism and functional role of macrophage colony‑stimulating factor in follicular granulosa cells.
Topics: Adult; Cell Line; Cell Proliferation; Cells, Cultured; Estradiol; Female; Follicle Stimulating Hormone; Gonadotropins; Humans; Letrozole; Luteal Cells; Macrophage Colony-Stimulating Factor; Nitriles; Triazoles | 2017 |
The role of hormonal therapy in patients with relapsed high-grade ovarian carcinoma: a retrospective series of tamoxifen and letrozole.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Carcinoma; Female; Humans; Letrozole; Middle Aged; Neoplasm Grading; Neoplasm Staging; Nitriles; Ovarian Neoplasms; Receptors, Estrogen; Recurrence; Retreatment; Retrospective Studies; Tamoxifen; Treatment Outcome; Triazoles; Young Adult | 2017 |
Long-term efficacy and safety of aromatase inhibitor use for leiomyomatosis peritonealis disseminata.
Topics: Adult; Aromatase Inhibitors; Female; Humans; Leiomyomatosis; Letrozole; Neoplasm Recurrence, Local; Nitriles; Pelvic Neoplasms; Peritoneal Cavity; Triazoles | 2017 |
High progesterone levels during the luteal phase related to the use of an aromatase inhibitor in breast cancer patients.
Topics: Adult; Aromatase Inhibitors; Breast Neoplasms; Chorionic Gonadotropin; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Humans; Letrozole; Luteal Phase; Nitriles; Ovulation Induction; Progesterone; Recombinant Proteins; Triazoles | 2017 |
Primary cytoreductive surgery and adjuvant hormonal monotherapy in women with advanced low-grade serous ovarian carcinoma: Reducing overtreatment without compromising survival?
Topics: Adult; Aged; Anastrozole; Antineoplastic Agents; Chemotherapy, Adjuvant; Combined Modality Therapy; Cystadenocarcinoma, Serous; Cytoreduction Surgical Procedures; Female; Humans; Letrozole; Medical Overuse; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Ovarian Neoplasms; Retrospective Studies; Survival Analysis; Tamoxifen; Triazoles | 2017 |
Does long-term androgen deficiency lead to metabolic syndrome in middle-aged rats?
Topics: Age Factors; Andropause; Animals; Aromatase Inhibitors; Biomarkers; Blood Glucose; Blood Pressure; Cholesterol; Disease Models, Animal; Estradiol; Female; Hormone Replacement Therapy; Hypogonadism; Letrozole; Liver; Liver Diseases; Male; Metabolic Syndrome; Nitriles; Orchiectomy; Ovariectomy; Rats, Inbred Lew; Sex Factors; Sexual Development; Testosterone; Triazoles; Uric Acid | 2017 |
Response of an ovarian granulosa cell tumor with everolimus and exemestane after initial response to letrozole.
Topics: Androstadienes; Antineoplastic Combined Chemotherapy Protocols; Everolimus; Female; Granulosa Cell Tumor; Humans; Letrozole; Middle Aged; Nitriles; Ovarian Neoplasms; Triazoles | 2017 |
Repression of ESR1 transcription by MYOD potentiates letrozole-resistance in ERα-positive breast cancer cells.
Topics: Breast Neoplasms; Cells, Cultured; Down-Regulation; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; Letrozole; MyoD Protein; Nitriles; Transcription, Genetic; Triazoles | 2017 |
Does daily co-administration of letrozole and gonadotropins during ovarian stimulation improve IVF outcome?
Topics: Adult; Case-Control Studies; Drug Administration Schedule; Drug Therapy, Combination; Female; Fertility Agents, Female; Fertilization in Vitro; Gonadotropins; Humans; Letrozole; Nitriles; Oocyte Retrieval; Ovulation Induction; Pregnancy; Pregnancy Rate; Retrospective Studies; Treatment Outcome; Triazoles | 2017 |
Ovarian Stimulation in Patients With Cancer: Impact of Letrozole and BRCA Mutations on Fertility Preservation Cycle Outcomes.
Topics: Adult; Aromatase Inhibitors; BRCA1 Protein; Cryopreservation; Female; Fertility Preservation; Fertilization in Vitro; Follicle Stimulating Hormone; Humans; Letrozole; Mutation; Neoplasms; Nitriles; Oocytes; Ovulation Induction; Triazoles; Young Adult | 2018 |
Kisspeptin expression features in the arcuate and anteroventral periventricular nuclei of hypothalamus of letrozole-induced polycystic ovarian syndrome in rats.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Female; Gonadal Steroid Hormones; Humans; Hypothalamus; Hypothalamus, Anterior; Kisspeptins; Letrozole; Luteinizing Hormone; Neurons; Nitriles; Pituitary Gland; Polycystic Ovary Syndrome; Rats; Rats, Wistar; Testosterone; Triazoles | 2017 |
Appendix 2: Advanced breast cancer: MCBS eUpdate published online 25 April 2017 (www.esmo.org/Guidelines/Breast-Cancer).
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Estradiol; Female; Fulvestrant; Humans; Letrozole; Medical Oncology; Nitriles; Piperazines; Pyridines; Triazoles | 2017 |
Hyperandrogenemia Induced by Letrozole Treatment of Pubertal Female Mice Results in Hyperinsulinemia Prior to Weight Gain and Insulin Resistance.
Topics: Animals; Eating; Energy Metabolism; Female; Glucose; Hyperandrogenism; Hyperinsulinism; Insulin Resistance; Letrozole; Mice; Mice, Inbred C57BL; Nitriles; Obesity; Sexual Maturation; Triazoles; Weight Gain | 2017 |
Protective effects of GABA against metabolic and reproductive disturbances in letrozole induced polycystic ovarian syndrome in rats.
Topics: Androgen Antagonists; Animals; Blood Glucose; Body Weight; Catalase; Estradiol; Female; gamma-Aminobutyric Acid; Insulin Resistance; Letrozole; Nitriles; Ovary; Peroxidase; Polycystic Ovary Syndrome; Protective Agents; Rats; Reproduction; Superoxide Dismutase; Testosterone; Triazoles | 2017 |
Surgery versus monitoring and endocrine therapy for low-risk DCIS: The COMET Trial.
Topics: Adult; Aged; Aromatase Inhibitors; Breast Neoplasms; Carcinoma in Situ; Carcinoma, Ductal, Breast; Combined Modality Therapy; Female; Guideline Adherence; Humans; Letrozole; Middle Aged; Nitriles; Outcome and Process Assessment, Health Care; Prospective Studies; Randomized Controlled Trials as Topic; Triazoles | 2017 |
Palbociclib in hormone receptor positive advanced breast cancer: A cost-utility analysis.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Computer Simulation; Cost-Benefit Analysis; Decision Support Techniques; Decision Trees; Drug Costs; Female; Humans; Letrozole; Models, Economic; Nitriles; Ontario; Piperazines; Protein Kinase Inhibitors; Pyridines; Quality of Life; Stochastic Processes; Time Factors; Treatment Outcome; Triazoles | 2017 |
Re: Clomiphene citrate and letrozole to reduce follicle-stimulating hormone consumption during ovarian stimulation: systematic review and meta-analysis. T. N. Bechtejew, M. N. Nadai, C. O. Nastri and W. P. Martins. Ultrasound Obstet Gynecol 2017; 50: 315-
Topics: Clomiphene; Follicle Stimulating Hormone; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Triazoles | 2017 |
Cardiac metastatic endometrial stromal sarcoma 17 years after hysterectomy.
Topics: Antineoplastic Agents; Cardiac Surgical Procedures; Chemotherapy, Adjuvant; Endometrial Neoplasms; Female; Heart Neoplasms; Heart Ventricles; Humans; Hysterectomy; Letrozole; Middle Aged; Nitriles; Sarcoma, Endometrial Stromal; Time Factors; Treatment Outcome; Triazoles | 2017 |
Ovulation induction and controlled ovarian stimulation using letrozole gonadotropin combination: A single center retrospective cohort study.
Topics: Adult; Drug Therapy, Combination; Endometriosis; Female; Fertility Agents, Female; Follicle Stimulating Hormone; Gonadotropins; Humans; Infertility, Female; Letrozole; Male; Nitriles; Ovarian Follicle; Ovulation; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Retrospective Studies; Triazoles | 2017 |
Increased sperm cell production in ageing roosters by an oral treatment with an aromatase inhibitor and a natural herbal extract designed for improving fertility.
Topics: Administration, Oral; Aging; Animals; Aromatase Inhibitors; Chickens; Epididymis; Infertility, Male; Letrozole; Male; Nitriles; Organ Size; Phytotherapy; Plant Extracts; Seminiferous Tubules; Spermatids; Spermatogenesis; Testis; Triazoles | 2017 |
Sex differences in behavioral and neurochemical effects of gonadectomy and aromatase inhibition in rats.
Topics: Animals; Antidepressive Agents; Aromatase; Aromatase Inhibitors; Behavior, Animal; Brain; Castration; Corticosterone; Depression; Female; Hippocampus; Letrozole; Male; Nitriles; Orchiectomy; Ovariectomy; Prefrontal Cortex; Rats; Rats, Wistar; Serotonin; Sex Characteristics; Testosterone; Triazoles | 2018 |
[Indoleamine 2,3-Dioxygenase Activity during Letrozol Therapy for an Elderly Breast Cancer Patient].
Topics: Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Letrozole; Mammography; Nitriles; Tomography, X-Ray Computed; Triazoles | 2017 |
Orbital fat regeneration following hormonal treatment of metastatic breast carcinoma.
Topics: Adipose Tissue; Aged; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Carcinoma, Lobular; Enophthalmos; Female; Humans; Letrozole; Nitriles; Orbit; Orbital Neoplasms; Regeneration; Tomography, X-Ray Computed; Triazoles | 2018 |
Folate Conjugated Hybrid Nanocarrier for Targeted Letrozole Delivery in Breast Cancer Treatment.
Topics: Animals; Antineoplastic Agents; Biological Availability; Breast Neoplasms; Cell Survival; Drug Carriers; Drug Delivery Systems; Drug Liberation; Female; Folic Acid; Humans; Letrozole; Male; MCF-7 Cells; Nanoparticles; Nitriles; Rats, Wistar; Triazoles | 2017 |
Effect of aromatase inhibitors on learning and memory and modulation of hippocampal dickkopf-1 and sclerostin in female mice.
Topics: Adaptor Proteins, Signal Transducing; Anastrozole; Androstadienes; Animals; Aromatase Inhibitors; Cognition; Female; Glycoproteins; Hippocampus; Intercellular Signaling Peptides and Proteins; Letrozole; Maze Learning; Memory; Mice; Nitriles; Triazoles; Wnt Signaling Pathway | 2017 |
Letrozole may be a valuable maintenance treatment in high-grade serous ovarian cancer patients.
Topics: Adult; Aged; Antineoplastic Agents; Cohort Studies; Cystadenocarcinoma, Serous; Datasets as Topic; Disease-Free Survival; Estrogen Receptor alpha; Female; Humans; Immunohistochemistry; Letrozole; Maintenance Chemotherapy; Middle Aged; Nitriles; Ovarian Neoplasms; Triazoles; Young Adult | 2018 |
Complexity of intermittent letrozole adjuvant therapy.
Topics: Breast Neoplasms; Chemotherapy, Adjuvant; Letrozole; Nitriles; Triazoles | 2018 |
Oxidative stress burden inhibits spermatogenesis in adult male rats: testosterone protective effect.
Topics: Aging; Animals; Biomarkers; Body Weight; Estradiol; Follicle Stimulating Hormone; Grape Seed Extract; Inflammation; Letrozole; Male; Methotrexate; Nitriles; Organ Size; Oxidative Stress; Protective Agents; Rats, Sprague-Dawley; Seminiferous Tubules; Sperm Count; Sperm Motility; Spermatogenesis; Testosterone; Triazoles | 2018 |
High-fat diet exposure from pre-pubertal age induces polycystic ovary syndrome (PCOS) in rats.
Topics: Animals; Aromatase Inhibitors; Biomarkers; Diet, High-Fat; Female; Gene Expression Profiling; Letrozole; Nitriles; Polycystic Ovary Syndrome; Rats; Rats, Sprague-Dawley; Sexual Maturation; Triazoles | 2018 |
Spinal Sigma-1 Receptor-mediated Dephosphorylation of Astrocytic Aromatase Plays a Key Role in Formalin-induced Inflammatory Nociception.
Topics: Animals; Aromatase; Aromatase Inhibitors; Astrocytes; Calcineurin; Formaldehyde; Glial Fibrillary Acidic Protein; Inflammation; Letrozole; Male; Mice, Inbred ICR; Nitriles; Nociceptive Pain; Oncogene Proteins v-fos; Phosphorylation; Receptors, sigma; Sigma-1 Receptor; Spinal Cord; Triazoles | 2018 |
Sister Mary Joseph nodule: a diagnostic challenge.
Topics: Abdomen; Aged; Antineoplastic Agents; Endometrial Neoplasms; Female; Humans; Hysterectomy; Letrozole; Nitriles; Salpingo-oophorectomy; Sister Mary Joseph's Nodule; Treatment Outcome; Triazoles | 2018 |
Antiandrogen Treatment Ameliorates Reproductive and Metabolic Phenotypes in the Letrozole-Induced Mouse Model of PCOS.
Topics: Adipocytes; Androgen Antagonists; Animals; Aromatase Inhibitors; Body Weight; Disease Models, Animal; Estrous Cycle; Female; Flutamide; Follicle Stimulating Hormone; Letrozole; Luteinizing Hormone; Mice; Nitriles; Ovary; Phenotype; Pituitary Gland; Polycystic Ovary Syndrome; Receptors, LHRH; Reproduction; Steroid 17-alpha-Hydroxylase; Testosterone; Triazoles | 2018 |
[A Case of Advanced Breast Cancer Effectively Treated with Bevacizumab and Letrozole].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Breast Neoplasms; Carcinoma, Ductal, Breast; Combined Modality Therapy; Female; Humans; Letrozole; Nitriles; Treatment Outcome; Triazoles | 2018 |
Expression profiles of mRNA and long noncoding RNA in the ovaries of letrozole-induced polycystic ovary syndrome rat model through deep sequencing.
Topics: Animals; Disease Models, Animal; Female; Gene Expression Profiling; Gene Expression Regulation; Gene Ontology; Gene Regulatory Networks; High-Throughput Nucleotide Sequencing; Humans; Letrozole; Nitriles; Ovary; Polycystic Ovary Syndrome; Rats; RNA, Long Noncoding; RNA, Messenger; Sequence Analysis, RNA; Triazoles | 2018 |
Therapeutic potentials of Quercetin in management of polycystic ovarian syndrome using Letrozole induced rat model: a histological and a biochemical study.
Topics: Animals; Antioxidants; Biomarkers; Biopsy; Body Weight; Disease Management; Disease Models, Animal; Estrous Cycle; Female; Humans; Letrozole; Lipid Metabolism; Lipids; Nitriles; Ovarian Follicle; Ovary; Polycystic Ovary Syndrome; Quercetin; Rats; Triazoles | 2018 |
GnRH dysregulation in polycystic ovarian syndrome (PCOS) is a manifestation of an altered neurotransmitter profile.
Topics: Acetylcholine; Animals; Dopamine; Female; Frontal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Gonadotropin-Releasing Hormone; Hippocampus; Hypothalamus; Letrozole; Neurotransmitter Agents; Nitriles; Pituitary Gland; Polycystic Ovary Syndrome; Rats; Rats, Inbred Strains; Serotonin; Triazoles | 2018 |
Influence of the conclusion of a recent large cooperative study in changing standard protocol of inducing menses in anovulatory women with oligomenorrhea prior to initiating ovulation induction with anti-estrogens and outcome.
Topics: Adult; Anovulation; Clomiphene; Endometrium; Estrogen Antagonists; Estrogens; Female; Fertility Agents, Female; Humans; Letrozole; Nitriles; Oligomenorrhea; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Triazoles | 2017 |
Tetragonia tetragonioides (Pall.) Kuntze Regulates Androgen Production in a Letrozole-Induced Polycystic Ovary Syndrome Model.
Topics: Aizoaceae; Androgens; Animals; Cell Line; Cell Survival; Cyclic AMP Response Element-Binding Protein; Dehydroepiandrosterone; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Female; Letrozole; Nitriles; Ovarian Follicle; Phytochemicals; Plant Extracts; Polycystic Ovary Syndrome; Rats; Signal Transduction; Testosterone; Triazoles | 2018 |
Late distant recurrence of breast carcinoma and metastasis to the main bronchus and choroid: A case report.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Biopsy; Breast Neoplasms; Bronchi; Bronchial Neoplasms; Bronchoscopy; Choroid; Choroid Neoplasms; Female; Fluorescein Angiography; Humans; Letrozole; Long Term Adverse Effects; Lymphatic Metastasis; Mastectomy; Middle Aged; Nitriles; Receptors, Estrogen; Treatment Outcome; Triazoles | 2018 |
Cost-Effectiveness of Ribociclib plus Letrozole Versus Palbociclib plus Letrozole and Letrozole Monotherapy in the First-Line Treatment of Postmenopausal Women with HR+/HER2- Advanced or Metastatic Breast Cancer: A U.S. Payer Perspective.
Topics: Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cost-Benefit Analysis; Disease-Free Survival; Female; Humans; Letrozole; Models, Biological; Models, Economic; Nitriles; Piperazines; Postmenopause; Protein Kinase Inhibitors; Purines; Pyridines; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Survival Analysis; Treatment Outcome; Triazoles; United States | 2018 |
Aromatase/Seladin-1 Interactions in Human Neuronal Cell Culture, the Hippocampus of Healthy Rats and Transgenic Alzheimer's Disease Mice.
Topics: Alzheimer Disease; Androstenes; Animals; Aromatase; Aromatase Inhibitors; Cells, Cultured; Dentate Gyrus; Female; Hippocampus; Humans; Infusions, Intraventricular; Letrozole; Male; Mice; Mice, Knockout; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Nitriles; Oxidoreductases Acting on CH-CH Group Donors; Rats; Triazoles | 2018 |
Comparison of the pregnancy outcomes and the incidence of fetal congenital abnormalities in infertile women treated with letrozole and clomiphene citrate.
Topics: Abnormalities, Drug-Induced; Adult; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Iran; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Outcome; Triazoles | 2018 |
A Retrospective Study of Letrozole Treatment Prior to Human Chorionic Gonadotropin in Women with Polycystic Ovary Syndrome Undergoing In Vitro Fertilization at Risk of Ovarian Hyperstimulation Syndrome.
Topics: Adult; China; Chorionic Gonadotropin; Embryo Transfer; Female; Fertilization in Vitro; Humans; Infertility, Female; Letrozole; Nitriles; Ovarian Hyperstimulation Syndrome; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Retrospective Studies; Triazoles | 2018 |
MicroRNA-16 Promotes Ovarian Granulosa Cell Proliferation and Suppresses Apoptosis Through Targeting PDCD4 in Polycystic Ovarian Syndrome.
Topics: 3' Untranslated Regions; Adult; Animals; Antagomirs; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Case-Control Studies; Cell Cycle Checkpoints; Cell Proliferation; Cells, Cultured; Estradiol; Female; Granulosa Cells; Humans; Letrozole; MicroRNAs; Nitriles; Polycystic Ovary Syndrome; Rats; Rats, Wistar; RNA-Binding Proteins; Triazoles | 2018 |
Mild ovarian stimulation with letrozole plus fixed dose human menopausal gonadotropin prior to IVF/ICSI for infertile non-obese women with polycystic ovarian syndrome being pre-treated with metformin: a pilot study.
Topics: Adult; Female; Gonadotropins; Humans; Infertility, Female; Letrozole; Metformin; Nitriles; Oocyte Retrieval; Ovarian Hyperstimulation Syndrome; Ovulation Induction; Pilot Projects; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Retrospective Studies; Sperm Injections, Intracytoplasmic; Triazoles | 2018 |
Letrozole for patients with polycystic ovary syndrome: A retrospective study.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitriles; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Outcome; Pregnancy Rate; Retrospective Studies; Treatment Outcome; Triazoles | 2018 |
New Potent 5α- Reductase and Aromatase Inhibitors Derived from 1,2,3-Triazole Derivative.
Topics: 5-alpha Reductase Inhibitors; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Antiviral Agents; Aromatase; Aromatase Inhibitors; Cholestenone 5 alpha-Reductase; Dihydrotestosterone; Letrozole; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Testosterone; Triazoles | 2020 |
Morphology and serum and bone tissue calcium and magnesium concentrations in the bones of male rats chronically treated with letrozole, a nonsteroidal cytochrome P450 aromatase inhibitor.
Topics: Animals; Aromatase; Aromatase Inhibitors; Bone and Bones; Calcium; Collagen; Estradiol; Estrogens; Letrozole; Magnesium; Male; Nitriles; Rats; Serum; Triazoles | 2021 |
Glyceollins Trigger Anti-Proliferative Effects in Hormone-Dependent Aromatase-Inhibitor-Resistant Breast Cancer Cells through the Induction of Apoptosis.
Topics: Apoptosis; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Estrogens; Female; Humans; Lapatinib; Letrozole; Neoplasm Recurrence, Local; Nitriles; Pterocarpans; Triazoles | 2022 |
Estrogen Promotes Microvascularization in the Fetus and Thus Vascular Function and Insulin Sensitivity in Offspring.
Topics: Animals; Estradiol; Estrogens; Female; Fetus; Glucose; Insulin; Insulin Resistance; Letrozole; Nitriles; Papio; Placenta; Pregnancy; Triazoles | 2022 |
Interaction of letrozole and its degradation products with aromatase: chemometric assessment of kinetics and structure-based binding validation.
Topics: Aromatase; Aromatase Inhibitors; Chemometrics; Female; Humans; Kinetics; Letrozole; Molecular Docking Simulation; Nitriles; Triazoles | 2022 |
Estrogen promotes fetal skeletal muscle myofiber development important for insulin sensitivity in offspring.
Topics: Animals; Aromatase Inhibitors; Estrogens; Fetal Development; Fetus; Insulin; Insulin Resistance; Letrozole; Muscle Development; Muscle, Skeletal; Nitriles; Papio; Triazoles | 2022 |
Letrozole treatment alters hippocampal gene expression in common marmosets (Callithrix jacchus).
Topics: Animals; Aromatase Inhibitors; Callithrix; Estrone; Female; Gene Expression; Hippocampus; Letrozole; Male; Nitriles; Triazoles | 2023 |
Effect of different timing of letrozole initiation on pregnancy outcome in polycystic ovary syndrome.
Topics: Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitriles; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Outcome; Retrospective Studies; Triazoles | 2022 |
Macrophages in juvenile pig testis: Link with increase in Sertoli cells induced by oestradiol suppression.
Topics: Animals; Aromatase Inhibitors; Estradiol; Estrogens; Letrozole; Male; Nitriles; Sertoli Cells; Swine; Testis; Triazoles | 2023 |
Ovarian Response can be Predicted in Women with PCOS who have Ovulation Induction with Letrozole.
Topics: Cohort Studies; Female; Fertility Agents, Female; Follicle Stimulating Hormone; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Testosterone; Triazoles | 2023 |
Novel Therapeutic Combination Targets the Growth of Letrozole-Resistant Breast Cancer through Decreased Cyclin B1.
Topics: Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Cyclin B1; Drug Resistance, Neoplasm; Estrogens; Female; Humans; Lapatinib; Letrozole; Mitogen-Activated Protein Kinases; Nitriles; Triazoles | 2023 |
Ovulation induction with letrozole and dexamethasone in infertile patients with letrozole-resistant polycystic ovary syndrome.
Topics: Clomiphene; Dexamethasone; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Retrospective Studies; Triazoles | 2023 |
Ferrozoles: Ferrocenyl derivatives of letrozole with dual effects as potent aromatase inhibitors and cytostatic agents.
Topics: Aromatase; Aromatase Inhibitors; Breast Neoplasms; Cytostatic Agents; Female; Humans; Letrozole; MCF-7 Cells; Metallocenes; Molecular Docking Simulation; Nitriles; Triazoles | 2023 |
Association between follicle size, endometrial thickness, and types of ovarian stimulation (Clomiphene citrate and Letrozole) with biochemical pregnancy rate in women undergone intrauterine insemination.
Topics: Case-Control Studies; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Insemination, Artificial; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Triazoles | 2023 |