Page last updated: 2024-08-24

triazoles and isoxazoles

triazoles has been researched along with isoxazoles in 84 studies

Research

Studies (84)

TimeframeStudies, this research(%)All Research%
pre-19903 (3.57)18.7374
1990's4 (4.76)18.2507
2000's9 (10.71)29.6817
2010's55 (65.48)24.3611
2020's13 (15.48)2.80

Authors

AuthorsStudies
Fotsch, C; St Jean, DJ1
Cheng, CC; Daves, GD1
Hall, IH; Izydore, RA; Simlot, R; Wong, OT2
Allen, SD; Bennett, GA; Kinsolving, CR; Mitchell, JT; Mullen, GB; St Georgiev, V; Swift, PA1
Iwagami, H; Sasaki, Y; Yasuda, N1
Sussman, N1
Hussar, DA2
Dalvie, DK; Kalgutkar, AS; Khojasteh-Bakht, SC; O'Donnell, JP; Obach, RS1
Asami, T; Bajguz, A1
Atack, JR; Bromidge, FA; Carling, RW; Castro, JL; Cook, S; Dawson, GR; Jelley, RA; MacLeod, AM; Marshall, G; McKernan, RM; Moore, KW; Pike, A; Pillai, GV; Reeve, AJ; Seabrook, GR; Sohal, B; Sternfeld, F; Street, LJ; Thompson, SA; Wafford, KA1
Vervaeren, J1
Fokin, VV; Hilgraf, R; Himo, F; Lovell, T; Noodleman, L; Rostovtsev, VV; Sharpless, KB1
Srinivasan, R; Uttamchandani, M; Yao, SQ1
Bellefleur, MA; Giguère, D; Patnam, R; Roy, R; Sato, S; St-Pierre, C1
Jung, M; Schemies, J; Sippl, W1
Albani, F; Baruzzi, A; Candela, C; Contin, M; Mohamed, S; Riva, R1
Nothnick, WB1
Caldas, SS; Costa, FP; Primel, EG1
Atack, JR1
Caffrey, M; Rong, LL; Wang, J; Wardrop, DJ; Yermolina, MV1
Greenhaw, J; Salminen, WF; Shi, Q; Yang, X1
Abe, S; Asada, M; Hata, K; Horii, T; Inoue, S; Matsukura, M; Miyazaki, M; Murai, N; Nakamoto, K; Shirotori, S; Tanaka, K; Watanabe, NA; Yoshimatsu, K1
Castanheira, M; Duncanson, F; Jones, RN; Messer, SA; Moet, GJ; Pfaller, MA1
Asad, N; Brzozowski, M; Hanson, PR; Hur, MY; Jeon, KO; Klimberg, SV; Lushington, GH; Neuenswander, B; Painter, TO; Porubsky, P; Rolfe, A; Santini, C1
Dechantsreiter, MA; Grob, JE; Hamann, LG; Nunez, J1
Castanheira, M; Diekema, DJ; Duncanson, FP; Guarro, J; Jones, RN; Pfaller, MA1
Docsa, T; Gergely, P; Kónya, B; Somsák, L1
Astrand, M; Boeckxstaens, GE; Hansen, MB; Hirsch, DP; Lei, A; Ny, L; Rohof, WO1
Dadmal, TL; Janaki Ramaiah, M; Kosurkar, UB; Kumbhare, RM; Pal-Bhadra, M; Pushpavalli, SN1
Cai, C; Lv, MF; Niu, TF; wang, L; Yi, WB1
Cselényi, Z; Halldin, C; Hooker, AC; Kågedal, M; Karlsson, MO; Nyberg, S; Raboisson, P; Ståhle, L; Stenkrona, P; Varnäs, K1
Bianchini, A; de Martinez Gaspar Martins, C; Gilberto Primel, E; Jaime de Menezes, E; Laura Venquiaruti Escarrone, A; Marian Bolzan, C; Souza Caldas, S1
Chrysikos, D; Dimopoulos, MA; Papadimitriou, CA; Psaltopoulou, T; Sergentanis, TN; Zagouri, F1
Andersson, A; Baranczewski, P; Nordmark, A; Ståhle, L; Wanag, E1
Bandini, L; Campisi, A; Carnovale, C; Chiacchio, MA; Giofrè, SV; Parenti, R; Romeo, R1
Pillai, RN; Ramalingam, SS1
Baum, L; Chan, PS; Kwan, P; Zhang, C; Zuo, Z1
Alloatti, D; Armaroli, S; Barbarino, M; Cabri, W; Carollo, V; Castorina, M; Cervoni, ML; Corsi, M; Ferrini, S; Foderà, R; Giannini, G; Giannotti, L; Guglielmi, MB; Manetti, F; Milazzo, FM; Pisano, C; Taddei, M; Vesci, L1
Ganesh Kumar, C; Jitender Dev, G; Narsaiah, B; Poornachandra, Y; Ratnakar Reddy, K; Sambasiva Rao, P; Shanthan Rao, P1
Corbin, JG; Huntsman, MM; Martin, BS1
Raboisson, P; Swedberg, MD1
Ara, T; Farooq, S; Kaul, A; Koul, S; Singh, J; Tripathi, VK1
Iwamura, T; Kainoh, M; Kawai, K; Kumagai, H; Nakaki, J; Nitta, A; Okazaki, S; Sakami, S; Sato, M; Sekiya, Y; Takahashi, T; Yagi, M1
Herring, WJ; Lines, C; Ma, J; Roth, T; Snyder, E; Svetnik, V1
Avanzo, RE; Carabelos, MN; D'Accorso, NB; Fascio, ML; Gueron, G; Schuster, F; Vazquez, E1
Bujak, A; Dymek, B; Dzwonek, K; Grygielewicz, P; Gunerka, P; Lamparska-Przybysz, M; Stanczak, A; Wieczorek, M; Zdzalik, D1
Al-Mossawi, MH; Bowness, P; Brennan, PE; de Wit, J; Fedorov, O; Hammitzsch, A; Hay, DA; Knapp, S; Martinez, FO; Müller, S; O'Mahony, A; Tallant, C; Vecellio, M; Wells, C; Wordsworth, P1
Anusha, S; Ashwini, N; Bender, A; Fuchs, JE; Garg, M; Kanojia, D; Koeffler, HP; Madan, V; Mohan, CD; Rakesh, KS; Rangappa, KS; Rangappa, S; Swaroop, TR1
Chong, Y; Lee, H; Lee, K1
Furukawa, S; Handa, H; Hashimoto, A; Hashimoto, S; Mikami, S; Oikawa, T; Okada, Y; Onodera, Y; Oya, M; Sabe, H; Sugino, H; Yoshikawa, A1
Ciamala, K; Gati, W; Knorr, M; Kubicki, MM; Mtiraoui, H; Rammah, Mel B; Rammah, MM; Rousselin, Y1
Alfonsi, R; Brunetti, M; Colaceci, F; Di Marcotullio, L; Filocamo, G; Lahm, A; Mancuso, M; Pasquali, E; Pazzaglia, S; Saran, A; Sasso, R; Steinkühler, C; Tanori, M1
Ang, D; De Santis, A; Pauwels, A; Scarpellini, E; Tack, J; Vanuytsel, T1
Bharath, G; Debanjan, B; Gangagni Rao, A; Jitender Dev, G; Krishna Swaroop, D; Naresh Kumar, R; Narsaiah, B; Nishant Jain, S; Ravikumar, N1
Brennan, PE; Burbano, R; Ceroni, A; Clark, PG; Dixon, D; Ebner, D; Fedorov, O; Gamble, V; Howarth, A; Knapp, S; Monteiro, O; Montenegro, RC; Müller, S; Nunez-Alonso, GA; O'Neill, E; Rogers, C; Siejka, P; Tallant, C; Wan, X1
Agarwal, PK; Hammerich, KH; Hao, JJ; Krane, LS; Li, QQ; Neckers, L; Sanford, T; Trepel, JB; Zhang, Z1
Aparicio, VC; Costa, JL; De Gerónimo, E; Menone, ML; Okada, E; Pérez, DJ1
Grose, C; Jadhav, A; Meier, JL; Shrimp, JH; Thorpe, AL; Widmeyer, SRT1
Kotapalli, SS; Murthy, NYS; Rao, YJ; Sowjanya, T; Thirupathi, G1
Acelas, M; Kouznetsov, VV; Romero Bohórquez, AR1
Bernardes, LSC; da Rosa, R; de Melo, EB; de Moraes, MH; Paula, FR; Schenkel, EP; Steindel, M; Zimmermann, LA1
Bristow, CC; Cristillo, AD; Dillon, JA; Dong, H; Grad, YH; Kirkcaldy, RD; Klausner, JD; Lawrence, K; Morris, SR; Nicholas, RA; Oldach, D; Rice, PA; Shafer, WM; Torrone, E; Wi, TE; Zhou, P1
Chernysheva, NB; Demchuk, DV; Kiselyov, AS; Kislyi, VP; Konyushkin, LD; Maksimenko, AS; Raihstat, MM; Samet, AV; Semenov, VV; Semenova, MN; Silyanova, EA; Tsyganov, DV; Varakutin, AE1
Covel, J; Fierer, J; Kapoor, M; Okamoto, S; Shaw, KJ; Soltow, QA; Trzoss, M; Viriyakosol, S1
Barrero, MJ; Garcia-Carpizo, V; González-Corpas, A; Ruiz-Llorente, S; Sarmentero, J1
Brown, LE; Chatterjee, S; Collins, C; Cowen, LE; Huang, DS; Hui, R; Hutchinson, A; Krysan, DJ; LeBlanc, EV; Lindquist, S; McLellan, CA; Nation, CS; Pizarro, J; Porco, JA; Robbins, N; Shekhar-Guturja, T; Tatu, U; Trilles, R; Whitesell, L; Xie, JL1
Lewis, DA1
Arruda, CCP; Barbosa, NV; Baroni, ACM; Carvalho, DB; das Neves, AR; Honorato, AM; Kadri, MCT; Kato, MJ; Moslaves, IS; Trefzger, OS; Yoshida, NC1
Harmon, SK; Jong, YI; O'Malley, KL1
Herring, WJ; Lines, C; Roth, T; Snyder, ES; Svetnik, V; Tao, P1
Borini Etichetti, CM; Cicetti, S; Girardini, JE; Sarotti, AM; Spanevello, RA; Suárez, AG; Tsai, YH1
Distel, L; Dobler, C; Fietkau, R; Hecht, M; Jost, T1
Eshleman, JR; Gulla, A; Kazlauskas, E; Liang, H; Matulis, D; Petrauskas, V; Strupas, K1
Al-Lazikani, B; Antolin, AA; Clarke, PA; Collins, I; Workman, P1
Abdelkafi-Koubaa, Z; Aissa, I; Assel, A; Ben Jannet, H; Chouaïb, K; Harrath, AH; Jalouli, M; Marrakchi, N; Romdhane, A1
Bürkel, F; Distel, LV; Faulhaber, EM; Fietkau, R; Hecht, M; Jost, T; Scheper, J; Symank, J1
Aparna, P; Bhavani, AKD; Gautier, F; Grée, R; Juin, P; Le Guevel, R; Levoin, N; Mosset, P; Murthy, AVR; Narendar, V; Reddy, CR; Roul, J; Sampath Kumar, N; Solhi, H1
Järvenpää, J; Küblbeck, J; Lahtela-Kakkonen, M; Rahnasto-Rilla, M1
Bahn, YS; Cheong, E; Choi, JW; Hwang, H; Kim, B; Kim, HJ; Kim, J; Kim, JW; Kim, R; Kim, S; Kim, Y; Lee, EH; Lee, HY; Lee, J; Park, JH; Park, KD; Park, SJ; Seo, SH; Yeon, SK1
Muzalevskiy, VM; Nechaev, MS; Nenajdenko, VG; Sizova, ZA1
Chi, X; Hao, Y; Jiang, Y; Li, L; Li, X; Ni, T; Wu, H; Xia, G; Xie, F; Yan, L; Zhang, D1
Basappa, B; Basappa, S; Gaonkar, SL; Krishnamurthy, NP; Lobie, PE; Mohan, A; Pandey, V; Ravish, A; Vishwanath, D; Xi, Z1

Reviews

12 review(s) available for triazoles and isoxazoles

ArticleYear
Mitigating heterocycle metabolism in drug discovery.
    Journal of medicinal chemistry, 2012, Jul-12, Volume: 55, Issue:13

    Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats

2012
The chemistry and biochemistry of C-nucleosides.
    Progress in medicinal chemistry, 1976, Volume: 13

    Topics: Animals; Anti-Bacterial Agents; Benzimidazoles; Chemical Phenomena; Chemistry; Formycins; Imidazoles; Isoxazoles; Nucleosides; Oxadiazoles; Pseudouridine; Purine Nucleosides; Pyrazoles; Showdomycin; Thiazoles; Triazoles; Uridine

1976
The potential benefits of serotonin receptor-specific agents.
    The Journal of clinical psychiatry, 1994, Volume: 55 Suppl

    Topics: Antidepressive Agents; Buspirone; Depressive Disorder; Humans; Isoxazoles; Ondansetron; Piperazines; Piperidines; Receptors, Serotonin; Risperidone; Selective Serotonin Reuptake Inhibitors; Serotonin; Sumatriptan; Triazoles

1994
Biotransformation reactions of five-membered aromatic heterocyclic rings.
    Chemical research in toxicology, 2002, Volume: 15, Issue:3

    Topics: Animals; Cytochrome P-450 Enzyme System; Furans; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Indoles; Isoxazoles; Models, Chemical; Molecular Structure; Oxadiazoles; Oxazoles; Pyrazoles; Pyrroles; Tetrazoles; Thiadiazoles; Thiazoles; Thiophenes; Triazoles; Xenobiotics

2002
Histone deacetylase inhibitors that target tubulin.
    Cancer letters, 2009, Aug-08, Volume: 280, Issue:2

    Topics: Acetylation; Binding Sites; Epigenesis, Genetic; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Isoxazoles; Models, Molecular; Naphthalenes; Protein Binding; Pyrones; Sirtuin 2; Sirtuins; Triazoles; Tubulin; Tubulin Modulators

2009
Endometriosis: in search of optimal treatment.
    Minerva ginecologica, 2010, Volume: 62, Issue:1

    Topics: Adalimumab; Anastrozole; Angiogenesis Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Aromatase Inhibitors; Endometriosis; Estrogen Receptor Modulators; Etanercept; Female; Gonadotropin-Releasing Hormone; Hormone Antagonists; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Letrozole; Nitriles; Pentoxifylline; Progesterone; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Triazoles; Tumor Necrosis Factor Decoy Receptors; Tumor Necrosis Factor-alpha

2010
GABAA receptor subtype-selective modulators. II. α5-selective inverse agonists for cognition enhancement.
    Current topics in medicinal chemistry, 2011, Volume: 11, Issue:9

    Topics: Animals; Benzodiazepines; Cognition; Diazepam; Female; Fluorobenzenes; GABA-A Receptor Agonists; Hippocampus; Humans; Isoxazoles; Male; Maze Learning; Memory; Mice; Nootropic Agents; Protein Isoforms; Pyridazines; Pyridines; Rats; Receptors, GABA-A; Structure-Activity Relationship; Substrate Specificity; Triazines; Triazoles

2011
Hsp90 inhibitors in breast cancer: a systematic review.
    Breast (Edinburgh, Scotland), 2013, Volume: 22, Issue:5

    Topics: Adenine; Antineoplastic Agents; Benzamides; Benzoquinones; Biomarkers, Tumor; Female; Glycine; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Indazoles; Isoxazoles; Lactams, Macrocyclic; Pyridines; Resorcinols; Triazoles; Triple Negative Breast Neoplasms

2013
Heat shock protein 90 inhibitors in non-small-cell lung cancer.
    Current opinion in oncology, 2014, Volume: 26, Issue:2

    Topics: Benzamides; Benzoquinones; Carcinoma, Non-Small-Cell Lung; HSP90 Heat-Shock Proteins; Humans; Isoindoles; Isoxazoles; Lactams, Macrocyclic; Lung Neoplasms; Molecular Targeted Therapy; Resorcinols; Treatment Outcome; Triazoles

2014
New treatment options for infections caused by increasingly antimicrobial-resistant Neisseria gonorrhoeae.
    Expert review of anti-infective therapy, 2016, Volume: 14, Issue:2

    Topics: Anti-Bacterial Agents; Azithromycin; Barbiturates; Ceftriaxone; Drug Resistance, Bacterial; Drug Therapy, Combination; Gonorrhea; Humans; Isoxazoles; Macrolides; Morpholines; Neisseria gonorrhoeae; Neisseriaceae Infections; Oxazolidinones; Pharyngitis; Spectinomycin; Spiro Compounds; Triazoles

2016
Management of refractory typical GERD symptoms.
    Nature reviews. Gastroenterology & hepatology, 2016, Volume: 13, Issue:5

    Topics: Alginates; Algorithms; Antacids; Baclofen; Chronic Disease; Esophagoscopy; Gastroesophageal Reflux; Gastrointestinal Agents; Gastroscopy; Humans; Isoxazoles; Muscle Relaxants, Central; Neurotransmitter Agents; Phosphinic Acids; Propylamines; Triazoles

2016
New treatment options for Neisseria gonorrhoeae in the era of emerging antimicrobial resistance.
    Sexual health, 2019, Volume: 16, Issue:5

    Topics: Acenaphthenes; Anti-Bacterial Agents; Barbiturates; Drug Development; Drug Resistance, Multiple, Bacterial; Gonorrhea; Heterocyclic Compounds, 3-Ring; Humans; Isoxazoles; Macrolides; Morpholines; Neisseria gonorrhoeae; Oxazolidinones; Spiro Compounds; Triazoles

2019

Trials

5 trial(s) available for triazoles and isoxazoles

ArticleYear
The effects of a novel metabotropic glutamate receptor 5 antagonist (AZD2066) on transient lower oesophageal sphincter relaxations and reflux episodes in healthy volunteers.
    Alimentary pharmacology & therapeutics, 2012, Volume: 35, Issue:10

    Topics: Adult; Analysis of Variance; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Esophageal Sphincter, Lower; Gastroesophageal Reflux; Gastrointestinal Agents; Humans; Hydrogen-Ion Concentration; Isoxazoles; Male; Postprandial Period; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Triazoles; Young Adult

2012
A positron emission tomography study in healthy volunteers to estimate mGluR5 receptor occupancy of AZD2066 - estimating occupancy in the absence of a reference region.
    NeuroImage, 2013, Nov-15, Volume: 82

    Topics: Adult; Analgesics; Anti-Anxiety Agents; Brain; Carbon Radioisotopes; Healthy Volunteers; Humans; Isoxazoles; Male; Middle Aged; Oximes; Positron-Emission Tomography; Pyridines; Radiopharmaceuticals; Receptor, Metabotropic Glutamate 5; Triazoles; Young Adult

2013
Assessment of interaction potential of AZD2066 using in vitro metabolism tools, physiologically based pharmacokinetic modelling and in vivo cocktail data.
    European journal of clinical pharmacology, 2014, Volume: 70, Issue:2

    Topics: Adult; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Isoxazoles; Male; Microsomes, Liver; Middle Aged; Models, Biological; Receptor, Metabotropic Glutamate 5; Triazoles; Young Adult

2014
Electroencephalographic power spectral density profile of the orexin receptor antagonist suvorexant in patients with primary insomnia and healthy subjects.
    Sleep, 2014, Oct-01, Volume: 37, Issue:10

    Topics: Adult; Aged; Azepines; Cross-Over Studies; Double-Blind Method; Electroencephalography; Female; Healthy Volunteers; Humans; Isoxazoles; Male; Middle Aged; Orexin Receptor Antagonists; Polysomnography; Pyridines; Sleep; Sleep Initiation and Maintenance Disorders; Triazoles; Young Adult; Zolpidem

2014
Antimicrobial Resistance in Neisseria gonorrhoeae: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting.
    Sexually transmitted diseases, 2019, Volume: 46, Issue:3

    Topics: Anti-Bacterial Agents; Antimicrobial Stewardship; Bacterial Vaccines; Barbiturates; Drug Resistance, Multiple, Bacterial; Epidemiological Monitoring; Gonorrhea; Group Processes; Humans; Isoxazoles; Macrolides; Microbial Sensitivity Tests; Morpholines; Mutation; Neisseria gonorrhoeae; Oxazolidinones; Public Health; Sexually Transmitted Diseases; Spiro Compounds; Topoisomerase Inhibitors; Triazoles; World Health Organization

2019

Other Studies

67 other study(ies) available for triazoles and isoxazoles

ArticleYear
Effects of isoxazolidine or triazolidine on rat serum lipids in vivo and LDL and HDL binding and degradation in human and rodent cultured cells in vitro.
    Research communications in chemical pathology and pharmacology, 1992, Volume: 77, Issue:3

    Topics: Animals; Aorta; Carrier Proteins; Cell Line; Cells, Cultured; Cholesterol; Cholesterol, HDL; Cholesterol, VLDL; Humans; Isoxazoles; Lipids; Lipoproteins, HDL; Lipoproteins, LDL; Liver; Macrophages; Male; Mice; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, LDL; Receptors, Lipoprotein; RNA-Binding Proteins; Triazoles; Triglycerides

1992
Potential aldose reductase inhibitors: 1,2,4-triazolidine-3,5-diones and 2-(3,4,5-trimethoxybenzoyl)-4,4-diethyl-3,5-isoxazolidinedione .
    Experientia, 1992, Apr-15, Volume: 48, Issue:4

    Topics: Aldehyde Reductase; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Erythrocytes; Isoxazoles; Lens, Crystalline; Male; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Structure-Activity Relationship; Triazoles

1992
In vitro antifungal activity of novel substituted 3,5-diphenyl-3-(1H-1,2,4-triazol-1-ylmethyl)-2- methylisoxazolidine derivatives.
    Annals of the New York Academy of Sciences, 1988, Volume: 544

    Topics: Antifungal Agents; Fungi; Isoxazoles; Microbial Sensitivity Tests; Molecular Structure; Oxazoles; Structure-Activity Relationship; Triazoles

1988
Synthesis and antibacterial activity of triazole and isoxazole derivatives of ampicillin.
    The Journal of antibiotics, 1983, Volume: 36, Issue:11

    Topics: Ampicillin; Anti-Bacterial Agents; Bacteria; Indicators and Reagents; Isoxazoles; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Oxazoles; Pseudomonas aeruginosa; Spectrophotometry, Infrared; Structure-Activity Relationship; Triazoles

1983
New drugs 99, Part IV.
    Nursing, 1999, Volume: 29, Issue:7

    Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Second-Generation; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Cefdinir; Cephalosporins; Citalopram; Drug Therapy; Etanercept; Humans; Immunoglobulin G; Isoxazoles; Leflunomide; Receptors, Tumor Necrosis Factor; Serotonin Receptor Agonists; Telmisartan; Tetrazoles; Triazoles; Tryptamines; United States; United States Food and Drug Administration

1999
Effects of brassinazole, an inhibitor of brassinosteroid biosynthesis, on light- and dark-grown Chlorella vulgaris.
    Planta, 2004, Volume: 218, Issue:5

    Topics: Brassinosteroids; Chlorella; Cholestanols; Darkness; Hemiterpenes; Isoxazoles; Light; Lovastatin; Organophosphorus Compounds; Oxazolidinones; Steroids, Heterocyclic; Triazoles

2004
Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site.
    Journal of medicinal chemistry, 2004, Jul-01, Volume: 47, Issue:14

    Topics: Administration, Oral; Animals; Binding Sites; Biological Availability; Cell Line; Female; GABA-A Receptor Agonists; Humans; Isoxazoles; Male; Maze Learning; Oocytes; Patch-Clamp Techniques; Phthalazines; Protein Subunits; Radioligand Assay; Rats; Structure-Activity Relationship; Triazoles; Xenopus laevis

2004
[Some new drugs: valdecoxib (Betra), voriconazole (Vfend), ezetimide (Ezetrol), teriparatide (Forsteo)].
    Journal de pharmacie de Belgique, 2004, Volume: 59, Issue:3

    Topics: Antifungal Agents; Azetidines; Cyclooxygenase Inhibitors; Ezetimibe; Female; Humans; Hypolipidemic Agents; Isoxazoles; Osteoporosis, Postmenopausal; Pyrimidines; Sulfonamides; Teriparatide; Triazoles; Voriconazole

2004
Copper(I)-catalyzed synthesis of azoles. DFT study predicts unprecedented reactivity and intermediates.
    Journal of the American Chemical Society, 2005, Jan-12, Volume: 127, Issue:1

    Topics: Catalysis; Cations, Monovalent; Copper; Isoxazoles; Models, Molecular; Nitriles; Thermodynamics; Triazoles

2005
Rapid assembly and in situ screening of bidentate inhibitors of protein tyrosine phosphatases.
    Organic letters, 2006, Feb-16, Volume: 8, Issue:4

    Topics: Binding Sites; Combinatorial Chemistry Techniques; Inhibitory Concentration 50; Isoxazoles; Molecular Structure; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Triazoles

2006
Carbohydrate triazoles and isoxazoles as inhibitors of galectins-1 and -3.
    Chemical communications (Cambridge, England), 2006, Jun-14, Issue:22

    Topics: Carbohydrates; Galectin 1; Galectin 3; Hemagglutination; Isoxazoles; Molecular Structure; Stereoisomerism; Structure-Activity Relationship; Triazoles

2006
New drug update: 2007.
    The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 2008, Volume: 23, Issue:4

    Topics: Aged; Amides; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antihypertensive Agents; Antiparkinson Agents; Antipsychotic Agents; Drug Approval; Fumarates; Humans; Hypoglycemic Agents; Isoxazoles; Macular Degeneration; Paliperidone Palmitate; Pyrazines; Pyrimidines; Ranibizumab; Sitagliptin Phosphate; Tetrahydronaphthalenes; Thiophenes; Triazoles; United States

2008
Simultaneous HPLC-UV analysis of rufinamide, zonisamide, lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in deproteinized plasma of patients with epilepsy.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010, Feb-01, Volume: 878, Issue:3-4

    Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Felbamate; Humans; Isoxazoles; Lamotrigine; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Triazines; Triazoles; Ultraviolet Rays; Zonisamide

2010
Validation of method for determination of different classes of pesticides in aqueous samples by dispersive liquid-liquid microextraction with liquid chromatography-tandem mass spectrometric detection.
    Analytica chimica acta, 2010, Apr-14, Volume: 665, Issue:1

    Topics: Carbofuran; Chemical Fractionation; Chromatography, High Pressure Liquid; Isoxazoles; Oxazolidinones; Pesticides; Tandem Mass Spectrometry; Triazoles; Water; Water Pollutants, Chemical

2010
Discovery, synthesis, and biological evaluation of a novel group of selective inhibitors of filoviral entry.
    Journal of medicinal chemistry, 2011, Feb-10, Volume: 54, Issue:3

    Topics: Antiviral Agents; Cell Line; Click Chemistry; Ebolavirus; Humans; Isoxazoles; Marburgvirus; Small Molecule Libraries; Stereoisomerism; Structure-Activity Relationship; Triazoles; Viral Envelope Proteins; Virology; Virus Internalization

2011
Hepatic cytochrome P450s attenuate the cytotoxicity induced by leflunomide and its active metabolite A77 1726 in primary cultured rat hepatocytes.
    Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 122, Issue:2

    Topics: Aniline Compounds; Animals; Benzoflavones; Biomarkers; Cell Survival; Cells, Cultured; Crotonates; Cytochrome P-450 Enzyme System; Hepatocytes; Hydroxybutyrates; Inactivation, Metabolic; Isoxazoles; Ketoconazole; Leflunomide; Liver; Male; Nitriles; Primary Cell Culture; Proadifen; Rats; Rats, Sprague-Dawley; Ticlopidine; Toluidines; Triazoles

2011
In vitro activity of E1210, a novel antifungal, against clinically important yeasts and molds.
    Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:10

    Topics: Aminopyridines; Amphotericin B; Antifungal Agents; Aspergillus; Candida; Cell Line; Echinocandins; Fluconazole; Fungi; Fusarium; Humans; Isoxazoles; Itraconazole; Lipopeptides; Micafungin; Microbial Sensitivity Tests; Paecilomyces; Pseudallescheria; Pyrimidines; Scedosporium; Triazoles; Voriconazole; Yeasts

2011
In vitro activity of a novel broad-spectrum antifungal, E1210, tested against Aspergillus spp. determined by CLSI and EUCAST broth microdilution methods.
    Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:11

    Topics: Aminopyridines; Anidulafungin; Antifungal Agents; Aspergillus; Aspergillus flavus; Aspergillus fumigatus; Caspofungin; Echinocandins; Isoxazoles; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Voriconazole

2011
Triazole-containing isothiazolidine 1,1-dioxide library synthesis: one-pot, multi-component protocols for small molecular probe discovery.
    ACS combinatorial science, 2011, Sep-12, Volume: 13, Issue:5

    Topics: Chemistry Techniques, Synthetic; Cyclic S-Oxides; Isoxazoles; Molecular Probes; Molecular Structure; Small Molecule Libraries; Stereoisomerism; Triazoles

2011
Regioselective synthesis and slow-release Suzuki-Miyaura cross-coupling of MIDA boronate-functionalized isoxazoles and triazoles.
    The Journal of organic chemistry, 2011, Dec-16, Volume: 76, Issue:24

    Topics: Boronic Acids; Chemistry Techniques, Synthetic; Green Chemistry Technology; Imino Acids; Isoxazoles; Magnetic Resonance Spectroscopy; Molecular Structure; Stereoisomerism; Triazoles

2011
Activities of E1210 and comparator agents tested by CLSI and EUCAST broth microdilution methods against Fusarium and Scedosporium species identified using molecular methods.
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:1

    Topics: Acylation; Aminopyridines; Amphotericin B; Anidulafungin; Antifungal Agents; Caspofungin; Echinocandins; Fusarium; Glycosylphosphatidylinositols; Humans; Inositol; Isoxazoles; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Pyrimidines; Scedosporium; Triazoles; Voriconazole

2012
Synthesis of heterocyclic N-(β-D-glucopyranosyl)carboxamides for inhibition of glycogen phosphorylase.
    Carbohydrate research, 2012, Apr-01, Volume: 351

    Topics: Animals; Chemistry Techniques, Synthetic; Enzyme Inhibitors; Glycogen Phosphorylase; Heterocyclic Compounds; Isoxazoles; Rabbits; Triazoles

2012
Synthesis and biological evaluation of novel triazoles and isoxazoles linked 2-phenyl benzothiazole as potential anticancer agents.
    Bioorganic & medicinal chemistry letters, 2012, Sep-01, Volume: 22, Issue:17

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Isoxazoles; Neoplasms; Structure-Activity Relationship; Thiazoles; Triazoles

2012
Chemoselective preparation of 1,2,3-triazole-isoxazole bisfunctional derivatives and their application in peptidomimetic synthesis.
    Organic & biomolecular chemistry, 2013, Feb-14, Volume: 11, Issue:6

    Topics: Isoxazoles; Molecular Structure; Peptidomimetics; Triazoles

2013
A vortex-assisted MSPD method for the extraction of pesticide residues from fish liver and crab hepatopancreas with determination by GC-MS.
    Talanta, 2013, Aug-15, Volume: 112

    Topics: Animals; Atrazine; Brachyura; Dimethoate; Environmental Monitoring; Fenitrothion; Gas Chromatography-Mass Spectrometry; Hepatopancreas; Isoxazoles; Liver; Malathion; Oxazolidinones; Perciformes; Pesticide Residues; Pyrazoles; Reproducibility of Results; Triazoles

2013
Synthesis and biological evaluation of 3-hydroxymethyl-5-(1H-1,2,3-triazol) isoxazolidines.
    Bioorganic & medicinal chemistry, 2013, Dec-15, Volume: 21, Issue:24

    Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Cell Proliferation; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Isoxazoles; Molecular Structure; Structure-Activity Relationship; Triazoles; Tumor Cells, Cultured

2013
In vitro transport assays of rufinamide, pregabalin, and zonisamide by human P-glycoprotein.
    Epilepsy research, 2014, Volume: 108, Issue:3

    Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line, Transformed; Dogs; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Gene Expression; Humans; Isoxazoles; Pregabalin; Rhodamine 123; Swine; Transfection; Triazoles; Zonisamide

2014
Synthesis and evaluation of new Hsp90 inhibitors based on a 1,4,5-trisubstituted 1,2,3-triazole scaffold.
    Journal of medicinal chemistry, 2014, Mar-27, Volume: 57, Issue:6

    Topics: Animals; Antineoplastic Agents; Blotting, Western; Catalysis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Computational Biology; Flow Cytometry; HSP90 Heat-Shock Proteins; Humans; Indicators and Reagents; Isoxazoles; Mice; Models, Molecular; Protein Binding; Resorcinols; Ruthenium; Spectrometry, Fluorescence; Structure-Activity Relationship; Triazoles; X-Ray Diffraction; Xenograft Model Antitumor Assays

2014
Synthesis of novel 1,2,3-triazole/isoxazole functionalized 2H-Chromene derivatives and their cytotoxic activity.
    Bioorganic & medicinal chemistry letters, 2014, Apr-01, Volume: 24, Issue:7

    Topics: Antineoplastic Agents; Benzopyrans; Cell Line, Tumor; Cell Proliferation; Cytotoxins; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Isoxazoles; MCF-7 Cells; Molecular Structure; Structure-Activity Relationship; Triazoles

2014
Deficient tonic GABAergic conductance and synaptic balance in the fragile X syndrome amygdala.
    Journal of neurophysiology, 2014, Aug-15, Volume: 112, Issue:4

    Topics: Amygdala; Animals; Excitatory Postsynaptic Potentials; Feedback, Physiological; Fragile X Mental Retardation Protein; Fragile X Syndrome; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GABAergic Neurons; Inhibitory Postsynaptic Potentials; Isoxazoles; Mice; Phthalazines; Protein Subunits; Pyridazines; Receptors, GABA-A; Synapses; Triazoles

2014
AZD9272 and AZD2066: selective and highly central nervous system penetrant mGluR5 antagonists characterized by their discriminative effects.
    The Journal of pharmacology and experimental therapeutics, 2014, Volume: 350, Issue:2

    Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Isoxazoles; Male; Oxadiazoles; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Thiazoles; Triazoles

2014
Synthesis and biological evaluation of novel isoxazoles and triazoles linked 6-hydroxycoumarin as potent cytotoxic agents.
    Bioorganic & medicinal chemistry letters, 2014, Sep-01, Volume: 24, Issue:17

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Coumarins; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HCT116 Cells; HL-60 Cells; Humans; Isoxazoles; Molecular Structure; Structure-Activity Relationship; Triazoles

2014
HIS-388, a novel orally active and long-acting 11β-hydroxysteroid dehydrogenase type 1 inhibitor, ameliorates insulin sensitivity and glucose intolerance in diet-induced obesity and nongenetic type 2 diabetic murine models.
    The Journal of pharmacology and experimental therapeutics, 2014, Volume: 351, Issue:1

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adamantane; Administration, Oral; Animals; Azepines; Carbenoxolone; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Female; Glucose Intolerance; Humans; Hypoglycemic Agents; Insulin Resistance; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Obesity; Pioglitazone; Thiazolidinediones; Triazoles

2014
Differential effect of heterocyclic D-ribofuranoside derivatives on human prostate cancer cell viability and cell cycle progression.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2014, Volume: 68, Issue:7

    Topics: Alkenes; Antineoplastic Agents; Carbohydrates; Cell Line, Tumor; Cell Survival; G1 Phase Cell Cycle Checkpoints; Humans; Isoxazoles; Male; Prostatic Neoplasms; Resting Phase, Cell Cycle; Triazoles

2014
Epithelial-mesenchymal transition confers resistance to selective FGFR inhibitors in SNU-16 gastric cancer cells.
    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2016, Volume: 19, Issue:1

    Topics: Antineoplastic Agents; Benzamides; Cell Line, Tumor; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Humans; Isoxazoles; Molecular Targeted Therapy; Oxazoles; Phenylurea Compounds; Piperazines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Receptor, Fibroblast Growth Factor, Type 2; Receptors, Fibroblast Growth Factor; Resorcinols; Stomach Neoplasms; Transforming Growth Factor beta1; Triazoles

2016
CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, Aug-25, Volume: 112, Issue:34

    Topics: Adult; Aged; Arthritis, Psoriatic; Azepines; Benzimidazoles; Calorimetry; CD4-Positive T-Lymphocytes; Cells, Cultured; Crystallography, X-Ray; Drug Evaluation, Preclinical; Female; Gene Expression Regulation; Humans; Immunosuppressive Agents; Interleukin-17; Isoxazoles; Kinetics; Male; Middle Aged; Models, Molecular; Molecular Structure; p300-CBP Transcription Factors; Protein Conformation; Protein Structure, Tertiary; Recombinant Proteins; Spondylitis, Ankylosing; Structure-Activity Relationship; Th17 Cells; Triazoles

2015
Synthesis of 1,2-benzisoxazole tethered 1,2,3-triazoles that exhibit anticancer activity in acute myeloid leukemia cell lines by inhibiting histone deacetylases, and inducing p21 and tubulin acetylation.
    Bioorganic & medicinal chemistry, 2015, Sep-15, Volume: 23, Issue:18

    Topics: Acetylation; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclin D; Cyclin-Dependent Kinase Inhibitor p21; G1 Phase Cell Cycle Checkpoints; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Isoxazoles; Leukemia, Myeloid, Acute; Mice; Mice, Inbred C57BL; Triazoles; Tubulin

2015
Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer.
    Nature communications, 2016, Feb-08, Volume: 7

    Topics: ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Adult; Aged; Aged, 80 and over; Amides; Animals; Antineoplastic Agents; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Female; GTP-Binding Protein alpha Subunits, G12-G13; Guanine Nucleotide Exchange Factors; HEK293 Cells; Humans; Immunohistochemistry; Indoles; Isoxazoles; Kidney Neoplasms; Lysophospholipids; Male; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Nerve Tissue Proteins; Propionates; Pyridines; Pyrroles; Receptors, Lysophosphatidic Acid; Signal Transduction; Sirolimus; Sunitinib; Triazoles

2016
Synthesis of Isoxazole and 1,2,3-Triazole Isoindole Derivatives via Silver- and Copper-Catalyzed 1,3-Dipolar Cycloaddition Reaction.
    Molecules (Basel, Switzerland), 2016, Mar-04, Volume: 21, Issue:3

    Topics: Catalysis; Copper; Crystallography, X-Ray; Cycloaddition Reaction; Isoindoles; Isoxazoles; Magnetic Resonance Spectroscopy; Silver; Spectrophotometry, Infrared; Triazoles

2016
MK-4101, a Potent Inhibitor of the Hedgehog Pathway, Is Highly Active against Medulloblastoma and Basal Cell Carcinoma.
    Molecular cancer therapeutics, 2016, Volume: 15, Issue:6

    Topics: Animals; Antineoplastic Agents; Carcinoma, Basal Cell; Cell Cycle; Cell Proliferation; Cell Survival; Cerebellar Neoplasms; Hedgehog Proteins; Humans; Isoxazoles; Medulloblastoma; Mice; Neoplasm Transplantation; Random Allocation; Signal Transduction; Triazoles; Xenograft Model Antitumor Assays

2016
Synthesis of novel triazole/isoxazole functionalized 7-(trifluoromethyl)pyrido[2,3-d]pyrimidine derivatives as promising anticancer and antibacterial agents.
    Bioorganic & medicinal chemistry letters, 2016, 06-15, Volume: 26, Issue:12

    Topics: Anti-Bacterial Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Isoxazoles; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship; Triazoles

2016
BET inhibition as a new strategy for the treatment of gastric cancer.
    Oncotarget, 2016, Jul-12, Volume: 7, Issue:28

    Topics: Apoptosis; Asian People; Azepines; Brazil; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Gene Expression Profiling; HEK293 Cells; Humans; Isoxazoles; Molecular Structure; Nuclear Proteins; Proto-Oncogene Proteins c-myc; Spheroids, Cellular; Stomach Neoplasms; Transcription Factors; Triazoles

2016
Proteomic analysis of proteome and histone post-translational modifications in heat shock protein 90 inhibition-mediated bladder cancer therapeutics.
    Scientific reports, 2017, 03-15, Volume: 7, Issue:1

    Topics: Antineoplastic Agents; Benzamides; Benzodioxoles; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 4 or More Rings; Histones; HSP90 Heat-Shock Proteins; Humans; Imidazoles; Isoindoles; Isoxazoles; Protein Processing, Post-Translational; Proteomics; Resorcinols; Triazoles; Urinary Bladder Neoplasms

2017
Spatial and temporal trends and flow dynamics of glyphosate and other pesticides within an agricultural watershed in Argentina.
    Environmental toxicology and chemistry, 2017, Volume: 36, Issue:12

    Topics: Argentina; Atrazine; Crops, Agricultural; Environmental Monitoring; Geologic Sediments; Glycine; Glyphosate; Herbicides; Isoxazoles; Neonicotinoids; Nitro Compounds; Organophosphonates; Pesticides; Rain; Rivers; Tetrazoles; Triazoles; Water Movements; Water Pollutants, Chemical

2017
Chemical Control of a CRISPR-Cas9 Acetyltransferase.
    ACS chemical biology, 2018, 02-16, Volume: 13, Issue:2

    Topics: Acetylation; Azepines; Benzimidazoles; Capsid Proteins; CRISPR-Associated Protein 9; CRISPR-Associated Proteins; CRISPR-Cas Systems; Cytomegalovirus; E1A-Associated p300 Protein; Enzyme Inhibitors; HEK293 Cells; Humans; Hydantoins; Interleukin 1 Receptor Antagonist Protein; Isoxazoles; Protein Domains; Recombinant Fusion Proteins; RNA, Guide, Kinetoplastida; Spiro Compounds; Streptococcus pyogenes; Transcription, Genetic; Transcriptional Activation; Triazoles

2018
Synthesis and biological evaluation of novel flavone/triazole/benzimidazole hybrids and flavone/isoxazole-annulated heterocycles as antiproliferative and antimycobacterial agents.
    Molecular diversity, 2018, Volume: 22, Issue:4

    Topics: Anti-Bacterial Agents; Antineoplastic Agents; Benzimidazoles; Cell Proliferation; Chemistry Techniques, Synthetic; Flavones; Humans; Inhibitory Concentration 50; Isoxazoles; MCF-7 Cells; Microbial Sensitivity Tests; Triazoles

2018
Facile and highly diastereo and regioselective synthesis of novel octahydroacridine-isoxazole and octahydroacridine-1,2,3-triazole molecular hybrids from citronella essential oil.
    Molecular diversity, 2019, Volume: 23, Issue:1

    Topics: Acridines; Alkynes; Catalysis; Copper; Cycloaddition Reaction; Cymbopogon; Isoxazoles; Oils, Volatile; Triazoles

2019
Synthesis and SAR of new isoxazole-triazole bis-heterocyclic compounds as analogues of natural lignans with antiparasitic activity.
    Bioorganic & medicinal chemistry, 2018, 09-15, Volume: 26, Issue:17

    Topics: Antiprotozoal Agents; Carbon-13 Magnetic Resonance Spectroscopy; Drug Evaluation, Preclinical; Heterocyclic Compounds; Humans; Isoxazoles; Leishmania; Lignans; NADH, NADPH Oxidoreductases; Proton Magnetic Resonance Spectroscopy; Spectrophotometry, Infrared; Structure-Activity Relationship; THP-1 Cells; Triazoles; Trypanosoma cruzi

2018
Sea Urchin Embryo Model As a Reliable in Vivo Phenotypic Screen to Characterize Selective Antimitotic Molecules. Comparative evaluation of Combretapyrazoles, -isoxazoles, -1,2,3-triazoles, and -pyrroles as Tubulin-Binding Agents.
    ACS combinatorial science, 2018, 12-10, Volume: 20, Issue:12

    Topics: Animals; Antimitotic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Embryo, Nonmammalian; Humans; Isoxazoles; Pyrazoles; Pyrroles; Sea Urchins; Structure-Activity Relationship; Triazoles; Tubulin; Tubulin Modulators

2018
APX001 and Other Gwt1 Inhibitor Prodrugs Are Effective in Experimental
    Antimicrobial agents and chemotherapy, 2019, Volume: 63, Issue:2

    Topics: Aminopyridines; Amphotericin B; Animals; Antifungal Agents; Coccidioides; Disease Models, Animal; Female; Fluconazole; Isoxazoles; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Pneumonia; Prodrugs; Triazoles

2019
CREBBP/EP300 Bromodomain Inhibition Affects the Proliferation of AR-Positive Breast Cancer Cell Lines.
    Molecular cancer research : MCR, 2019, Volume: 17, Issue:3

    Topics: Androgens; Azepines; Benzimidazoles; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; CREB-Binding Protein; Down-Regulation; E1A-Associated p300 Protein; Female; Gene Expression Regulation, Neoplastic; Humans; Isoxazoles; Protein Domains; Receptors, Androgen; Triazoles

2019
Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.
    Nature communications, 2019, 01-24, Volume: 10, Issue:1

    Topics: Animals; Antifungal Agents; Candida albicans; Cell Line; Drug Resistance, Fungal; Fungal Proteins; Heterocyclic Compounds, 4 or More Rings; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Mice; Models, Molecular; Molecular Chaperones; Protein Binding; Protein Conformation; Protein Domains; Recombinant Proteins; Resorcinols; Signal Transduction; Triazoles; Virulence

2019
Effect of isoxazole derivatives of tetrahydrofuran neolignans on intracellular amastigotes of Leishmania (Leishmania) amazonensis: A structure-activity relationship comparative study with triazole-neolignan-based compounds.
    Chemical biology & drug design, 2019, Volume: 94, Issue:6

    Topics: Animals; Antiprotozoal Agents; Drug Design; Female; Furans; Inhibitory Concentration 50; Isoxazoles; Leishmania; Life Cycle Stages; Lignans; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Nitric Oxide; Structure-Activity Relationship; Triazoles

2019
Location and Cell-Type-Specific Bias of Metabotropic Glutamate Receptor, mGlu
    ACS chemical neuroscience, 2019, 11-20, Volume: 10, Issue:11

    Topics: Allosteric Regulation; Animals; Animals, Newborn; Brain; Cells, Cultured; HEK293 Cells; Humans; Indoles; Isoxazoles; Rats; Receptor, Metabotropic Glutamate 5; Triazoles

2019
How well can a large number of polysomnography sleep measures predict subjective sleep quality in insomnia patients?
    Sleep medicine, 2020, Volume: 67

    Topics: Age Factors; Analgesics; Azepines; Female; Humans; Isoxazoles; Male; Middle Aged; Polysomnography; Predictive Value of Tests; Sleep Aids, Pharmaceutical; Sleep Hygiene; Sleep Initiation and Maintenance Disorders; Time Factors; Triazoles

2020
Design, synthesis and evaluation of novel levoglucosenone derivatives as promising anticancer agents.
    Bioorganic & medicinal chemistry letters, 2020, 07-15, Volume: 30, Issue:14

    Topics: Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Glucose; Humans; Isoxazoles; Molecular Structure; Structure-Activity Relationship; Triazoles

2020
Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells.
    Cells, 2020, 09-01, Volume: 9, Issue:9

    Topics: Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Cycle; Cell Line, Tumor; Cellular Senescence; DNA Damage; Fibroblasts; Head and Neck Neoplasms; Humans; Isoxazoles; Male; Protein Kinase Inhibitors; Pyrazines; Pyridines; Quinolines; Radiation, Ionizing; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; TOR Serine-Threonine Kinases; Triazoles

2020
Heat Shock Protein 90 Inhibitor Effects on Pancreatic Cancer Cell Cultures.
    Pancreas, 2021, 04-01, Volume: 50, Issue:4

    Topics: Adenosine Triphosphatases; Antineoplastic Agents; Benzamides; Benzoquinones; Carcinoma, Pancreatic Ductal; Cell Culture Techniques, Three Dimensional; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; HSP90 Heat-Shock Proteins; Humans; Isoindoles; Isoxazoles; Lactams, Macrocyclic; Molecular Structure; Pancreatic Neoplasms; Resorcinols; Rifabutin; Triazoles

2021
Evolution of kinase polypharmacology across HSP90 drug discovery.
    Cell chemical biology, 2021, 10-21, Volume: 28, Issue:10

    Topics: Binding Sites; Discoidin Domain Receptor 1; Drug Discovery; Evolution, Molecular; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Molecular Docking Simulation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Resorcinols; Triazoles

2021
Glioblastoma-specific anticancer activity of newly synthetized 3,5-disubstituted isoxazole and 1,4-disubstituted triazole-linked tyrosol conjugates.
    Bioorganic chemistry, 2021, Volume: 114

    Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Glioblastoma; Humans; Isoxazoles; Molecular Structure; Phenylethyl Alcohol; Structure-Activity Relationship; Triazoles; Tumor Cells, Cultured

2021
Kinase Inhibitors of DNA-PK, ATM and ATR in Combination with Ionizing Radiation Can Increase Tumor Cell Death in HNSCC Cells While Sparing Normal Tissue Cells.
    Genes, 2021, 06-17, Volume: 12, Issue:6

    Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma, Squamous Cell; Cell Death; Cell Line, Tumor; Cells, Cultured; DNA Repair; DNA-Activated Protein Kinase; Head and Neck Neoplasms; Humans; Isoxazoles; Protein Kinase Inhibitors; Pyrazines; Pyridines; Quinolines; Triazoles; X-Rays

2021
Synthesis and biological studies of new piperidino-1,2,3-triazole hybrids with 3-aryl isoxazole side chains.
    Bioorganic & medicinal chemistry letters, 2021, 11-15, Volume: 52

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Isoxazoles; Models, Molecular; Molecular Structure; Piperidines; Structure-Activity Relationship; Triazoles

2021
Profiling the regulatory interplay of BET bromodomains and Sirtuins in cancer cell lines.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 147

    Topics: Azepines; Benzazepines; Benzodiazepines; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Humans; Isoxazoles; Proteins; Sirtuins; Transcription Factors; Triazoles

2022
Discovery of Novel Sphingosine-1-Phosphate-1 Receptor Agonists for the Treatment of Multiple Sclerosis.
    Journal of medicinal chemistry, 2022, 02-24, Volume: 65, Issue:4

    Topics: Animals; beta-Arrestins; Dogs; Drug Design; Encephalomyelitis, Autoimmune, Experimental; Heart Rate; Humans; Isoxazoles; Lymphocyte Count; Lymphocytes; Male; Mice; Multiple Sclerosis; Rats; Sphingosine-1-Phosphate Receptors; Structure-Activity Relationship; Triazoles

2022
Acid-Switchable Synthesis of Trifluoromethylated Triazoles and Isoxazoles via Reaction of CF
    International journal of molecular sciences, 2022, Nov-22, Volume: 23, Issue:23

    Topics: Acids; Catalysis; Isoxazoles; Triazoles

2022
Discovery of novel triazoles containing benzyloxy phenyl isoxazole side chain with potent and broad-spectrum antifungal activity.
    Bioorganic chemistry, 2023, Volume: 137

    Topics: Antifungal Agents; Candida albicans; Cryptococcus neoformans; Humans; Isoxazoles; Microbial Sensitivity Tests; Structure-Activity Relationship; Triazoles

2023
Electrochemical Synthesis of New Isoxazoles and Triazoles Tethered with Thiouracil Base as Inhibitors of Histone Deacetylases in Human Breast Cancer Cells.
    Molecules (Basel, Switzerland), 2023, Jul-06, Volume: 28, Issue:13

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Isoxazoles; Structure-Activity Relationship; Triazoles

2023