triazoles has been researched along with isoxazoles in 84 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (3.57) | 18.7374 |
| 1990's | 4 (4.76) | 18.2507 |
| 2000's | 9 (10.71) | 29.6817 |
| 2010's | 55 (65.48) | 24.3611 |
| 2020's | 13 (15.48) | 2.80 |
| Authors | Studies |
|---|---|
| Fotsch, C; St Jean, DJ | 1 |
| Cheng, CC; Daves, GD | 1 |
| Hall, IH; Izydore, RA; Simlot, R; Wong, OT | 2 |
| Allen, SD; Bennett, GA; Kinsolving, CR; Mitchell, JT; Mullen, GB; St Georgiev, V; Swift, PA | 1 |
| Iwagami, H; Sasaki, Y; Yasuda, N | 1 |
| Sussman, N | 1 |
| Hussar, DA | 2 |
| Dalvie, DK; Kalgutkar, AS; Khojasteh-Bakht, SC; O'Donnell, JP; Obach, RS | 1 |
| Asami, T; Bajguz, A | 1 |
| Atack, JR; Bromidge, FA; Carling, RW; Castro, JL; Cook, S; Dawson, GR; Jelley, RA; MacLeod, AM; Marshall, G; McKernan, RM; Moore, KW; Pike, A; Pillai, GV; Reeve, AJ; Seabrook, GR; Sohal, B; Sternfeld, F; Street, LJ; Thompson, SA; Wafford, KA | 1 |
| Vervaeren, J | 1 |
| Fokin, VV; Hilgraf, R; Himo, F; Lovell, T; Noodleman, L; Rostovtsev, VV; Sharpless, KB | 1 |
| Srinivasan, R; Uttamchandani, M; Yao, SQ | 1 |
| Bellefleur, MA; Giguère, D; Patnam, R; Roy, R; Sato, S; St-Pierre, C | 1 |
| Jung, M; Schemies, J; Sippl, W | 1 |
| Albani, F; Baruzzi, A; Candela, C; Contin, M; Mohamed, S; Riva, R | 1 |
| Nothnick, WB | 1 |
| Caldas, SS; Costa, FP; Primel, EG | 1 |
| Atack, JR | 1 |
| Caffrey, M; Rong, LL; Wang, J; Wardrop, DJ; Yermolina, MV | 1 |
| Greenhaw, J; Salminen, WF; Shi, Q; Yang, X | 1 |
| Abe, S; Asada, M; Hata, K; Horii, T; Inoue, S; Matsukura, M; Miyazaki, M; Murai, N; Nakamoto, K; Shirotori, S; Tanaka, K; Watanabe, NA; Yoshimatsu, K | 1 |
| Castanheira, M; Duncanson, F; Jones, RN; Messer, SA; Moet, GJ; Pfaller, MA | 1 |
| Asad, N; Brzozowski, M; Hanson, PR; Hur, MY; Jeon, KO; Klimberg, SV; Lushington, GH; Neuenswander, B; Painter, TO; Porubsky, P; Rolfe, A; Santini, C | 1 |
| Dechantsreiter, MA; Grob, JE; Hamann, LG; Nunez, J | 1 |
| Castanheira, M; Diekema, DJ; Duncanson, FP; Guarro, J; Jones, RN; Pfaller, MA | 1 |
| Docsa, T; Gergely, P; Kónya, B; Somsák, L | 1 |
| Astrand, M; Boeckxstaens, GE; Hansen, MB; Hirsch, DP; Lei, A; Ny, L; Rohof, WO | 1 |
| Dadmal, TL; Janaki Ramaiah, M; Kosurkar, UB; Kumbhare, RM; Pal-Bhadra, M; Pushpavalli, SN | 1 |
| Cai, C; Lv, MF; Niu, TF; wang, L; Yi, WB | 1 |
| Cselényi, Z; Halldin, C; Hooker, AC; Kågedal, M; Karlsson, MO; Nyberg, S; Raboisson, P; Ståhle, L; Stenkrona, P; Varnäs, K | 1 |
| Bianchini, A; de Martinez Gaspar Martins, C; Gilberto Primel, E; Jaime de Menezes, E; Laura Venquiaruti Escarrone, A; Marian Bolzan, C; Souza Caldas, S | 1 |
| Chrysikos, D; Dimopoulos, MA; Papadimitriou, CA; Psaltopoulou, T; Sergentanis, TN; Zagouri, F | 1 |
| Andersson, A; Baranczewski, P; Nordmark, A; Ståhle, L; Wanag, E | 1 |
| Bandini, L; Campisi, A; Carnovale, C; Chiacchio, MA; Giofrè, SV; Parenti, R; Romeo, R | 1 |
| Pillai, RN; Ramalingam, SS | 1 |
| Baum, L; Chan, PS; Kwan, P; Zhang, C; Zuo, Z | 1 |
| Alloatti, D; Armaroli, S; Barbarino, M; Cabri, W; Carollo, V; Castorina, M; Cervoni, ML; Corsi, M; Ferrini, S; Foderà, R; Giannini, G; Giannotti, L; Guglielmi, MB; Manetti, F; Milazzo, FM; Pisano, C; Taddei, M; Vesci, L | 1 |
| Ganesh Kumar, C; Jitender Dev, G; Narsaiah, B; Poornachandra, Y; Ratnakar Reddy, K; Sambasiva Rao, P; Shanthan Rao, P | 1 |
| Corbin, JG; Huntsman, MM; Martin, BS | 1 |
| Raboisson, P; Swedberg, MD | 1 |
| Ara, T; Farooq, S; Kaul, A; Koul, S; Singh, J; Tripathi, VK | 1 |
| Iwamura, T; Kainoh, M; Kawai, K; Kumagai, H; Nakaki, J; Nitta, A; Okazaki, S; Sakami, S; Sato, M; Sekiya, Y; Takahashi, T; Yagi, M | 1 |
| Herring, WJ; Lines, C; Ma, J; Roth, T; Snyder, E; Svetnik, V | 1 |
| Avanzo, RE; Carabelos, MN; D'Accorso, NB; Fascio, ML; Gueron, G; Schuster, F; Vazquez, E | 1 |
| Bujak, A; Dymek, B; Dzwonek, K; Grygielewicz, P; Gunerka, P; Lamparska-Przybysz, M; Stanczak, A; Wieczorek, M; Zdzalik, D | 1 |
| Al-Mossawi, MH; Bowness, P; Brennan, PE; de Wit, J; Fedorov, O; Hammitzsch, A; Hay, DA; Knapp, S; Martinez, FO; Müller, S; O'Mahony, A; Tallant, C; Vecellio, M; Wells, C; Wordsworth, P | 1 |
| Anusha, S; Ashwini, N; Bender, A; Fuchs, JE; Garg, M; Kanojia, D; Koeffler, HP; Madan, V; Mohan, CD; Rakesh, KS; Rangappa, KS; Rangappa, S; Swaroop, TR | 1 |
| Chong, Y; Lee, H; Lee, K | 1 |
| Furukawa, S; Handa, H; Hashimoto, A; Hashimoto, S; Mikami, S; Oikawa, T; Okada, Y; Onodera, Y; Oya, M; Sabe, H; Sugino, H; Yoshikawa, A | 1 |
| Ciamala, K; Gati, W; Knorr, M; Kubicki, MM; Mtiraoui, H; Rammah, Mel B; Rammah, MM; Rousselin, Y | 1 |
| Alfonsi, R; Brunetti, M; Colaceci, F; Di Marcotullio, L; Filocamo, G; Lahm, A; Mancuso, M; Pasquali, E; Pazzaglia, S; Saran, A; Sasso, R; Steinkühler, C; Tanori, M | 1 |
| Ang, D; De Santis, A; Pauwels, A; Scarpellini, E; Tack, J; Vanuytsel, T | 1 |
| Bharath, G; Debanjan, B; Gangagni Rao, A; Jitender Dev, G; Krishna Swaroop, D; Naresh Kumar, R; Narsaiah, B; Nishant Jain, S; Ravikumar, N | 1 |
| Brennan, PE; Burbano, R; Ceroni, A; Clark, PG; Dixon, D; Ebner, D; Fedorov, O; Gamble, V; Howarth, A; Knapp, S; Monteiro, O; Montenegro, RC; Müller, S; Nunez-Alonso, GA; O'Neill, E; Rogers, C; Siejka, P; Tallant, C; Wan, X | 1 |
| Agarwal, PK; Hammerich, KH; Hao, JJ; Krane, LS; Li, QQ; Neckers, L; Sanford, T; Trepel, JB; Zhang, Z | 1 |
| Aparicio, VC; Costa, JL; De Gerónimo, E; Menone, ML; Okada, E; Pérez, DJ | 1 |
| Grose, C; Jadhav, A; Meier, JL; Shrimp, JH; Thorpe, AL; Widmeyer, SRT | 1 |
| Kotapalli, SS; Murthy, NYS; Rao, YJ; Sowjanya, T; Thirupathi, G | 1 |
| Acelas, M; Kouznetsov, VV; Romero Bohórquez, AR | 1 |
| Bernardes, LSC; da Rosa, R; de Melo, EB; de Moraes, MH; Paula, FR; Schenkel, EP; Steindel, M; Zimmermann, LA | 1 |
| Bristow, CC; Cristillo, AD; Dillon, JA; Dong, H; Grad, YH; Kirkcaldy, RD; Klausner, JD; Lawrence, K; Morris, SR; Nicholas, RA; Oldach, D; Rice, PA; Shafer, WM; Torrone, E; Wi, TE; Zhou, P | 1 |
| Chernysheva, NB; Demchuk, DV; Kiselyov, AS; Kislyi, VP; Konyushkin, LD; Maksimenko, AS; Raihstat, MM; Samet, AV; Semenov, VV; Semenova, MN; Silyanova, EA; Tsyganov, DV; Varakutin, AE | 1 |
| Covel, J; Fierer, J; Kapoor, M; Okamoto, S; Shaw, KJ; Soltow, QA; Trzoss, M; Viriyakosol, S | 1 |
| Barrero, MJ; Garcia-Carpizo, V; González-Corpas, A; Ruiz-Llorente, S; Sarmentero, J | 1 |
| Brown, LE; Chatterjee, S; Collins, C; Cowen, LE; Huang, DS; Hui, R; Hutchinson, A; Krysan, DJ; LeBlanc, EV; Lindquist, S; McLellan, CA; Nation, CS; Pizarro, J; Porco, JA; Robbins, N; Shekhar-Guturja, T; Tatu, U; Trilles, R; Whitesell, L; Xie, JL | 1 |
| Lewis, DA | 1 |
| Arruda, CCP; Barbosa, NV; Baroni, ACM; Carvalho, DB; das Neves, AR; Honorato, AM; Kadri, MCT; Kato, MJ; Moslaves, IS; Trefzger, OS; Yoshida, NC | 1 |
| Harmon, SK; Jong, YI; O'Malley, KL | 1 |
| Herring, WJ; Lines, C; Roth, T; Snyder, ES; Svetnik, V; Tao, P | 1 |
| Borini Etichetti, CM; Cicetti, S; Girardini, JE; Sarotti, AM; Spanevello, RA; Suárez, AG; Tsai, YH | 1 |
| Distel, L; Dobler, C; Fietkau, R; Hecht, M; Jost, T | 1 |
| Eshleman, JR; Gulla, A; Kazlauskas, E; Liang, H; Matulis, D; Petrauskas, V; Strupas, K | 1 |
| Al-Lazikani, B; Antolin, AA; Clarke, PA; Collins, I; Workman, P | 1 |
| Abdelkafi-Koubaa, Z; Aissa, I; Assel, A; Ben Jannet, H; Chouaïb, K; Harrath, AH; Jalouli, M; Marrakchi, N; Romdhane, A | 1 |
| Bürkel, F; Distel, LV; Faulhaber, EM; Fietkau, R; Hecht, M; Jost, T; Scheper, J; Symank, J | 1 |
| Aparna, P; Bhavani, AKD; Gautier, F; Grée, R; Juin, P; Le Guevel, R; Levoin, N; Mosset, P; Murthy, AVR; Narendar, V; Reddy, CR; Roul, J; Sampath Kumar, N; Solhi, H | 1 |
| Järvenpää, J; Küblbeck, J; Lahtela-Kakkonen, M; Rahnasto-Rilla, M | 1 |
| Bahn, YS; Cheong, E; Choi, JW; Hwang, H; Kim, B; Kim, HJ; Kim, J; Kim, JW; Kim, R; Kim, S; Kim, Y; Lee, EH; Lee, HY; Lee, J; Park, JH; Park, KD; Park, SJ; Seo, SH; Yeon, SK | 1 |
| Muzalevskiy, VM; Nechaev, MS; Nenajdenko, VG; Sizova, ZA | 1 |
| Chi, X; Hao, Y; Jiang, Y; Li, L; Li, X; Ni, T; Wu, H; Xia, G; Xie, F; Yan, L; Zhang, D | 1 |
| Basappa, B; Basappa, S; Gaonkar, SL; Krishnamurthy, NP; Lobie, PE; Mohan, A; Pandey, V; Ravish, A; Vishwanath, D; Xi, Z | 1 |
12 review(s) available for triazoles and isoxazoles
| Article | Year |
|---|---|
Mitigating heterocycle metabolism in drug discovery.
Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats | 2012 |
The chemistry and biochemistry of C-nucleosides.
Topics: Animals; Anti-Bacterial Agents; Benzimidazoles; Chemical Phenomena; Chemistry; Formycins; Imidazoles; Isoxazoles; Nucleosides; Oxadiazoles; Pseudouridine; Purine Nucleosides; Pyrazoles; Showdomycin; Thiazoles; Triazoles; Uridine | 1976 |
The potential benefits of serotonin receptor-specific agents.
Topics: Antidepressive Agents; Buspirone; Depressive Disorder; Humans; Isoxazoles; Ondansetron; Piperazines; Piperidines; Receptors, Serotonin; Risperidone; Selective Serotonin Reuptake Inhibitors; Serotonin; Sumatriptan; Triazoles | 1994 |
Biotransformation reactions of five-membered aromatic heterocyclic rings.
Topics: Animals; Cytochrome P-450 Enzyme System; Furans; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Indoles; Isoxazoles; Models, Chemical; Molecular Structure; Oxadiazoles; Oxazoles; Pyrazoles; Pyrroles; Tetrazoles; Thiadiazoles; Thiazoles; Thiophenes; Triazoles; Xenobiotics | 2002 |
Histone deacetylase inhibitors that target tubulin.
Topics: Acetylation; Binding Sites; Epigenesis, Genetic; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Isoxazoles; Models, Molecular; Naphthalenes; Protein Binding; Pyrones; Sirtuin 2; Sirtuins; Triazoles; Tubulin; Tubulin Modulators | 2009 |
Endometriosis: in search of optimal treatment.
Topics: Adalimumab; Anastrozole; Angiogenesis Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Aromatase Inhibitors; Endometriosis; Estrogen Receptor Modulators; Etanercept; Female; Gonadotropin-Releasing Hormone; Hormone Antagonists; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Letrozole; Nitriles; Pentoxifylline; Progesterone; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Triazoles; Tumor Necrosis Factor Decoy Receptors; Tumor Necrosis Factor-alpha | 2010 |
GABAA receptor subtype-selective modulators. II. α5-selective inverse agonists for cognition enhancement.
Topics: Animals; Benzodiazepines; Cognition; Diazepam; Female; Fluorobenzenes; GABA-A Receptor Agonists; Hippocampus; Humans; Isoxazoles; Male; Maze Learning; Memory; Mice; Nootropic Agents; Protein Isoforms; Pyridazines; Pyridines; Rats; Receptors, GABA-A; Structure-Activity Relationship; Substrate Specificity; Triazines; Triazoles | 2011 |
Hsp90 inhibitors in breast cancer: a systematic review.
Topics: Adenine; Antineoplastic Agents; Benzamides; Benzoquinones; Biomarkers, Tumor; Female; Glycine; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Indazoles; Isoxazoles; Lactams, Macrocyclic; Pyridines; Resorcinols; Triazoles; Triple Negative Breast Neoplasms | 2013 |
Heat shock protein 90 inhibitors in non-small-cell lung cancer.
Topics: Benzamides; Benzoquinones; Carcinoma, Non-Small-Cell Lung; HSP90 Heat-Shock Proteins; Humans; Isoindoles; Isoxazoles; Lactams, Macrocyclic; Lung Neoplasms; Molecular Targeted Therapy; Resorcinols; Treatment Outcome; Triazoles | 2014 |
New treatment options for infections caused by increasingly antimicrobial-resistant Neisseria gonorrhoeae.
Topics: Anti-Bacterial Agents; Azithromycin; Barbiturates; Ceftriaxone; Drug Resistance, Bacterial; Drug Therapy, Combination; Gonorrhea; Humans; Isoxazoles; Macrolides; Morpholines; Neisseria gonorrhoeae; Neisseriaceae Infections; Oxazolidinones; Pharyngitis; Spectinomycin; Spiro Compounds; Triazoles | 2016 |
Management of refractory typical GERD symptoms.
Topics: Alginates; Algorithms; Antacids; Baclofen; Chronic Disease; Esophagoscopy; Gastroesophageal Reflux; Gastrointestinal Agents; Gastroscopy; Humans; Isoxazoles; Muscle Relaxants, Central; Neurotransmitter Agents; Phosphinic Acids; Propylamines; Triazoles | 2016 |
New treatment options for Neisseria gonorrhoeae in the era of emerging antimicrobial resistance.
Topics: Acenaphthenes; Anti-Bacterial Agents; Barbiturates; Drug Development; Drug Resistance, Multiple, Bacterial; Gonorrhea; Heterocyclic Compounds, 3-Ring; Humans; Isoxazoles; Macrolides; Morpholines; Neisseria gonorrhoeae; Oxazolidinones; Spiro Compounds; Triazoles | 2019 |
5 trial(s) available for triazoles and isoxazoles
| Article | Year |
|---|---|
The effects of a novel metabotropic glutamate receptor 5 antagonist (AZD2066) on transient lower oesophageal sphincter relaxations and reflux episodes in healthy volunteers.
Topics: Adult; Analysis of Variance; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Esophageal Sphincter, Lower; Gastroesophageal Reflux; Gastrointestinal Agents; Humans; Hydrogen-Ion Concentration; Isoxazoles; Male; Postprandial Period; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Triazoles; Young Adult | 2012 |
A positron emission tomography study in healthy volunteers to estimate mGluR5 receptor occupancy of AZD2066 - estimating occupancy in the absence of a reference region.
Topics: Adult; Analgesics; Anti-Anxiety Agents; Brain; Carbon Radioisotopes; Healthy Volunteers; Humans; Isoxazoles; Male; Middle Aged; Oximes; Positron-Emission Tomography; Pyridines; Radiopharmaceuticals; Receptor, Metabotropic Glutamate 5; Triazoles; Young Adult | 2013 |
Assessment of interaction potential of AZD2066 using in vitro metabolism tools, physiologically based pharmacokinetic modelling and in vivo cocktail data.
Topics: Adult; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Isoxazoles; Male; Microsomes, Liver; Middle Aged; Models, Biological; Receptor, Metabotropic Glutamate 5; Triazoles; Young Adult | 2014 |
Electroencephalographic power spectral density profile of the orexin receptor antagonist suvorexant in patients with primary insomnia and healthy subjects.
Topics: Adult; Aged; Azepines; Cross-Over Studies; Double-Blind Method; Electroencephalography; Female; Healthy Volunteers; Humans; Isoxazoles; Male; Middle Aged; Orexin Receptor Antagonists; Polysomnography; Pyridines; Sleep; Sleep Initiation and Maintenance Disorders; Triazoles; Young Adult; Zolpidem | 2014 |
Antimicrobial Resistance in Neisseria gonorrhoeae: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting.
Topics: Anti-Bacterial Agents; Antimicrobial Stewardship; Bacterial Vaccines; Barbiturates; Drug Resistance, Multiple, Bacterial; Epidemiological Monitoring; Gonorrhea; Group Processes; Humans; Isoxazoles; Macrolides; Microbial Sensitivity Tests; Morpholines; Mutation; Neisseria gonorrhoeae; Oxazolidinones; Public Health; Sexually Transmitted Diseases; Spiro Compounds; Topoisomerase Inhibitors; Triazoles; World Health Organization | 2019 |
67 other study(ies) available for triazoles and isoxazoles
| Article | Year |
|---|---|
Effects of isoxazolidine or triazolidine on rat serum lipids in vivo and LDL and HDL binding and degradation in human and rodent cultured cells in vitro.
Topics: Animals; Aorta; Carrier Proteins; Cell Line; Cells, Cultured; Cholesterol; Cholesterol, HDL; Cholesterol, VLDL; Humans; Isoxazoles; Lipids; Lipoproteins, HDL; Lipoproteins, LDL; Liver; Macrophages; Male; Mice; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, LDL; Receptors, Lipoprotein; RNA-Binding Proteins; Triazoles; Triglycerides | 1992 |
Potential aldose reductase inhibitors: 1,2,4-triazolidine-3,5-diones and 2-(3,4,5-trimethoxybenzoyl)-4,4-diethyl-3,5-isoxazolidinedione .
Topics: Aldehyde Reductase; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Erythrocytes; Isoxazoles; Lens, Crystalline; Male; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Structure-Activity Relationship; Triazoles | 1992 |
In vitro antifungal activity of novel substituted 3,5-diphenyl-3-(1H-1,2,4-triazol-1-ylmethyl)-2- methylisoxazolidine derivatives.
Topics: Antifungal Agents; Fungi; Isoxazoles; Microbial Sensitivity Tests; Molecular Structure; Oxazoles; Structure-Activity Relationship; Triazoles | 1988 |
Synthesis and antibacterial activity of triazole and isoxazole derivatives of ampicillin.
Topics: Ampicillin; Anti-Bacterial Agents; Bacteria; Indicators and Reagents; Isoxazoles; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Oxazoles; Pseudomonas aeruginosa; Spectrophotometry, Infrared; Structure-Activity Relationship; Triazoles | 1983 |
New drugs 99, Part IV.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Second-Generation; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Cefdinir; Cephalosporins; Citalopram; Drug Therapy; Etanercept; Humans; Immunoglobulin G; Isoxazoles; Leflunomide; Receptors, Tumor Necrosis Factor; Serotonin Receptor Agonists; Telmisartan; Tetrazoles; Triazoles; Tryptamines; United States; United States Food and Drug Administration | 1999 |
Effects of brassinazole, an inhibitor of brassinosteroid biosynthesis, on light- and dark-grown Chlorella vulgaris.
Topics: Brassinosteroids; Chlorella; Cholestanols; Darkness; Hemiterpenes; Isoxazoles; Light; Lovastatin; Organophosphorus Compounds; Oxazolidinones; Steroids, Heterocyclic; Triazoles | 2004 |
Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site.
Topics: Administration, Oral; Animals; Binding Sites; Biological Availability; Cell Line; Female; GABA-A Receptor Agonists; Humans; Isoxazoles; Male; Maze Learning; Oocytes; Patch-Clamp Techniques; Phthalazines; Protein Subunits; Radioligand Assay; Rats; Structure-Activity Relationship; Triazoles; Xenopus laevis | 2004 |
[Some new drugs: valdecoxib (Betra), voriconazole (Vfend), ezetimide (Ezetrol), teriparatide (Forsteo)].
Topics: Antifungal Agents; Azetidines; Cyclooxygenase Inhibitors; Ezetimibe; Female; Humans; Hypolipidemic Agents; Isoxazoles; Osteoporosis, Postmenopausal; Pyrimidines; Sulfonamides; Teriparatide; Triazoles; Voriconazole | 2004 |
Copper(I)-catalyzed synthesis of azoles. DFT study predicts unprecedented reactivity and intermediates.
Topics: Catalysis; Cations, Monovalent; Copper; Isoxazoles; Models, Molecular; Nitriles; Thermodynamics; Triazoles | 2005 |
Rapid assembly and in situ screening of bidentate inhibitors of protein tyrosine phosphatases.
Topics: Binding Sites; Combinatorial Chemistry Techniques; Inhibitory Concentration 50; Isoxazoles; Molecular Structure; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Triazoles | 2006 |
Carbohydrate triazoles and isoxazoles as inhibitors of galectins-1 and -3.
Topics: Carbohydrates; Galectin 1; Galectin 3; Hemagglutination; Isoxazoles; Molecular Structure; Stereoisomerism; Structure-Activity Relationship; Triazoles | 2006 |
New drug update: 2007.
Topics: Aged; Amides; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antihypertensive Agents; Antiparkinson Agents; Antipsychotic Agents; Drug Approval; Fumarates; Humans; Hypoglycemic Agents; Isoxazoles; Macular Degeneration; Paliperidone Palmitate; Pyrazines; Pyrimidines; Ranibizumab; Sitagliptin Phosphate; Tetrahydronaphthalenes; Thiophenes; Triazoles; United States | 2008 |
Simultaneous HPLC-UV analysis of rufinamide, zonisamide, lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in deproteinized plasma of patients with epilepsy.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Felbamate; Humans; Isoxazoles; Lamotrigine; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Triazines; Triazoles; Ultraviolet Rays; Zonisamide | 2010 |
Validation of method for determination of different classes of pesticides in aqueous samples by dispersive liquid-liquid microextraction with liquid chromatography-tandem mass spectrometric detection.
Topics: Carbofuran; Chemical Fractionation; Chromatography, High Pressure Liquid; Isoxazoles; Oxazolidinones; Pesticides; Tandem Mass Spectrometry; Triazoles; Water; Water Pollutants, Chemical | 2010 |
Discovery, synthesis, and biological evaluation of a novel group of selective inhibitors of filoviral entry.
Topics: Antiviral Agents; Cell Line; Click Chemistry; Ebolavirus; Humans; Isoxazoles; Marburgvirus; Small Molecule Libraries; Stereoisomerism; Structure-Activity Relationship; Triazoles; Viral Envelope Proteins; Virology; Virus Internalization | 2011 |
Hepatic cytochrome P450s attenuate the cytotoxicity induced by leflunomide and its active metabolite A77 1726 in primary cultured rat hepatocytes.
Topics: Aniline Compounds; Animals; Benzoflavones; Biomarkers; Cell Survival; Cells, Cultured; Crotonates; Cytochrome P-450 Enzyme System; Hepatocytes; Hydroxybutyrates; Inactivation, Metabolic; Isoxazoles; Ketoconazole; Leflunomide; Liver; Male; Nitriles; Primary Cell Culture; Proadifen; Rats; Rats, Sprague-Dawley; Ticlopidine; Toluidines; Triazoles | 2011 |
In vitro activity of E1210, a novel antifungal, against clinically important yeasts and molds.
Topics: Aminopyridines; Amphotericin B; Antifungal Agents; Aspergillus; Candida; Cell Line; Echinocandins; Fluconazole; Fungi; Fusarium; Humans; Isoxazoles; Itraconazole; Lipopeptides; Micafungin; Microbial Sensitivity Tests; Paecilomyces; Pseudallescheria; Pyrimidines; Scedosporium; Triazoles; Voriconazole; Yeasts | 2011 |
In vitro activity of a novel broad-spectrum antifungal, E1210, tested against Aspergillus spp. determined by CLSI and EUCAST broth microdilution methods.
Topics: Aminopyridines; Anidulafungin; Antifungal Agents; Aspergillus; Aspergillus flavus; Aspergillus fumigatus; Caspofungin; Echinocandins; Isoxazoles; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Voriconazole | 2011 |
Triazole-containing isothiazolidine 1,1-dioxide library synthesis: one-pot, multi-component protocols for small molecular probe discovery.
Topics: Chemistry Techniques, Synthetic; Cyclic S-Oxides; Isoxazoles; Molecular Probes; Molecular Structure; Small Molecule Libraries; Stereoisomerism; Triazoles | 2011 |
Regioselective synthesis and slow-release Suzuki-Miyaura cross-coupling of MIDA boronate-functionalized isoxazoles and triazoles.
Topics: Boronic Acids; Chemistry Techniques, Synthetic; Green Chemistry Technology; Imino Acids; Isoxazoles; Magnetic Resonance Spectroscopy; Molecular Structure; Stereoisomerism; Triazoles | 2011 |
Activities of E1210 and comparator agents tested by CLSI and EUCAST broth microdilution methods against Fusarium and Scedosporium species identified using molecular methods.
Topics: Acylation; Aminopyridines; Amphotericin B; Anidulafungin; Antifungal Agents; Caspofungin; Echinocandins; Fusarium; Glycosylphosphatidylinositols; Humans; Inositol; Isoxazoles; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Pyrimidines; Scedosporium; Triazoles; Voriconazole | 2012 |
Synthesis of heterocyclic N-(β-D-glucopyranosyl)carboxamides for inhibition of glycogen phosphorylase.
Topics: Animals; Chemistry Techniques, Synthetic; Enzyme Inhibitors; Glycogen Phosphorylase; Heterocyclic Compounds; Isoxazoles; Rabbits; Triazoles | 2012 |
Synthesis and biological evaluation of novel triazoles and isoxazoles linked 2-phenyl benzothiazole as potential anticancer agents.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Isoxazoles; Neoplasms; Structure-Activity Relationship; Thiazoles; Triazoles | 2012 |
Chemoselective preparation of 1,2,3-triazole-isoxazole bisfunctional derivatives and their application in peptidomimetic synthesis.
Topics: Isoxazoles; Molecular Structure; Peptidomimetics; Triazoles | 2013 |
A vortex-assisted MSPD method for the extraction of pesticide residues from fish liver and crab hepatopancreas with determination by GC-MS.
Topics: Animals; Atrazine; Brachyura; Dimethoate; Environmental Monitoring; Fenitrothion; Gas Chromatography-Mass Spectrometry; Hepatopancreas; Isoxazoles; Liver; Malathion; Oxazolidinones; Perciformes; Pesticide Residues; Pyrazoles; Reproducibility of Results; Triazoles | 2013 |
Synthesis and biological evaluation of 3-hydroxymethyl-5-(1H-1,2,3-triazol) isoxazolidines.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Cell Proliferation; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Isoxazoles; Molecular Structure; Structure-Activity Relationship; Triazoles; Tumor Cells, Cultured | 2013 |
In vitro transport assays of rufinamide, pregabalin, and zonisamide by human P-glycoprotein.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line, Transformed; Dogs; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Gene Expression; Humans; Isoxazoles; Pregabalin; Rhodamine 123; Swine; Transfection; Triazoles; Zonisamide | 2014 |
Synthesis and evaluation of new Hsp90 inhibitors based on a 1,4,5-trisubstituted 1,2,3-triazole scaffold.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Catalysis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Computational Biology; Flow Cytometry; HSP90 Heat-Shock Proteins; Humans; Indicators and Reagents; Isoxazoles; Mice; Models, Molecular; Protein Binding; Resorcinols; Ruthenium; Spectrometry, Fluorescence; Structure-Activity Relationship; Triazoles; X-Ray Diffraction; Xenograft Model Antitumor Assays | 2014 |
Synthesis of novel 1,2,3-triazole/isoxazole functionalized 2H-Chromene derivatives and their cytotoxic activity.
Topics: Antineoplastic Agents; Benzopyrans; Cell Line, Tumor; Cell Proliferation; Cytotoxins; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Isoxazoles; MCF-7 Cells; Molecular Structure; Structure-Activity Relationship; Triazoles | 2014 |
Deficient tonic GABAergic conductance and synaptic balance in the fragile X syndrome amygdala.
Topics: Amygdala; Animals; Excitatory Postsynaptic Potentials; Feedback, Physiological; Fragile X Mental Retardation Protein; Fragile X Syndrome; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GABAergic Neurons; Inhibitory Postsynaptic Potentials; Isoxazoles; Mice; Phthalazines; Protein Subunits; Pyridazines; Receptors, GABA-A; Synapses; Triazoles | 2014 |
AZD9272 and AZD2066: selective and highly central nervous system penetrant mGluR5 antagonists characterized by their discriminative effects.
Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Isoxazoles; Male; Oxadiazoles; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Thiazoles; Triazoles | 2014 |
Synthesis and biological evaluation of novel isoxazoles and triazoles linked 6-hydroxycoumarin as potent cytotoxic agents.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Coumarins; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HCT116 Cells; HL-60 Cells; Humans; Isoxazoles; Molecular Structure; Structure-Activity Relationship; Triazoles | 2014 |
HIS-388, a novel orally active and long-acting 11β-hydroxysteroid dehydrogenase type 1 inhibitor, ameliorates insulin sensitivity and glucose intolerance in diet-induced obesity and nongenetic type 2 diabetic murine models.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adamantane; Administration, Oral; Animals; Azepines; Carbenoxolone; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Female; Glucose Intolerance; Humans; Hypoglycemic Agents; Insulin Resistance; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Obesity; Pioglitazone; Thiazolidinediones; Triazoles | 2014 |
Differential effect of heterocyclic D-ribofuranoside derivatives on human prostate cancer cell viability and cell cycle progression.
Topics: Alkenes; Antineoplastic Agents; Carbohydrates; Cell Line, Tumor; Cell Survival; G1 Phase Cell Cycle Checkpoints; Humans; Isoxazoles; Male; Prostatic Neoplasms; Resting Phase, Cell Cycle; Triazoles | 2014 |
Epithelial-mesenchymal transition confers resistance to selective FGFR inhibitors in SNU-16 gastric cancer cells.
Topics: Antineoplastic Agents; Benzamides; Cell Line, Tumor; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Humans; Isoxazoles; Molecular Targeted Therapy; Oxazoles; Phenylurea Compounds; Piperazines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Receptor, Fibroblast Growth Factor, Type 2; Receptors, Fibroblast Growth Factor; Resorcinols; Stomach Neoplasms; Transforming Growth Factor beta1; Triazoles | 2016 |
CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses.
Topics: Adult; Aged; Arthritis, Psoriatic; Azepines; Benzimidazoles; Calorimetry; CD4-Positive T-Lymphocytes; Cells, Cultured; Crystallography, X-Ray; Drug Evaluation, Preclinical; Female; Gene Expression Regulation; Humans; Immunosuppressive Agents; Interleukin-17; Isoxazoles; Kinetics; Male; Middle Aged; Models, Molecular; Molecular Structure; p300-CBP Transcription Factors; Protein Conformation; Protein Structure, Tertiary; Recombinant Proteins; Spondylitis, Ankylosing; Structure-Activity Relationship; Th17 Cells; Triazoles | 2015 |
Synthesis of 1,2-benzisoxazole tethered 1,2,3-triazoles that exhibit anticancer activity in acute myeloid leukemia cell lines by inhibiting histone deacetylases, and inducing p21 and tubulin acetylation.
Topics: Acetylation; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclin D; Cyclin-Dependent Kinase Inhibitor p21; G1 Phase Cell Cycle Checkpoints; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Isoxazoles; Leukemia, Myeloid, Acute; Mice; Mice, Inbred C57BL; Triazoles; Tubulin | 2015 |
Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer.
Topics: ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Adult; Aged; Aged, 80 and over; Amides; Animals; Antineoplastic Agents; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Female; GTP-Binding Protein alpha Subunits, G12-G13; Guanine Nucleotide Exchange Factors; HEK293 Cells; Humans; Immunohistochemistry; Indoles; Isoxazoles; Kidney Neoplasms; Lysophospholipids; Male; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Nerve Tissue Proteins; Propionates; Pyridines; Pyrroles; Receptors, Lysophosphatidic Acid; Signal Transduction; Sirolimus; Sunitinib; Triazoles | 2016 |
Synthesis of Isoxazole and 1,2,3-Triazole Isoindole Derivatives via Silver- and Copper-Catalyzed 1,3-Dipolar Cycloaddition Reaction.
Topics: Catalysis; Copper; Crystallography, X-Ray; Cycloaddition Reaction; Isoindoles; Isoxazoles; Magnetic Resonance Spectroscopy; Silver; Spectrophotometry, Infrared; Triazoles | 2016 |
MK-4101, a Potent Inhibitor of the Hedgehog Pathway, Is Highly Active against Medulloblastoma and Basal Cell Carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Basal Cell; Cell Cycle; Cell Proliferation; Cell Survival; Cerebellar Neoplasms; Hedgehog Proteins; Humans; Isoxazoles; Medulloblastoma; Mice; Neoplasm Transplantation; Random Allocation; Signal Transduction; Triazoles; Xenograft Model Antitumor Assays | 2016 |
Synthesis of novel triazole/isoxazole functionalized 7-(trifluoromethyl)pyrido[2,3-d]pyrimidine derivatives as promising anticancer and antibacterial agents.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Isoxazoles; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship; Triazoles | 2016 |
BET inhibition as a new strategy for the treatment of gastric cancer.
Topics: Apoptosis; Asian People; Azepines; Brazil; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Gene Expression Profiling; HEK293 Cells; Humans; Isoxazoles; Molecular Structure; Nuclear Proteins; Proto-Oncogene Proteins c-myc; Spheroids, Cellular; Stomach Neoplasms; Transcription Factors; Triazoles | 2016 |
Proteomic analysis of proteome and histone post-translational modifications in heat shock protein 90 inhibition-mediated bladder cancer therapeutics.
Topics: Antineoplastic Agents; Benzamides; Benzodioxoles; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 4 or More Rings; Histones; HSP90 Heat-Shock Proteins; Humans; Imidazoles; Isoindoles; Isoxazoles; Protein Processing, Post-Translational; Proteomics; Resorcinols; Triazoles; Urinary Bladder Neoplasms | 2017 |
Spatial and temporal trends and flow dynamics of glyphosate and other pesticides within an agricultural watershed in Argentina.
Topics: Argentina; Atrazine; Crops, Agricultural; Environmental Monitoring; Geologic Sediments; Glycine; Glyphosate; Herbicides; Isoxazoles; Neonicotinoids; Nitro Compounds; Organophosphonates; Pesticides; Rain; Rivers; Tetrazoles; Triazoles; Water Movements; Water Pollutants, Chemical | 2017 |
Chemical Control of a CRISPR-Cas9 Acetyltransferase.
Topics: Acetylation; Azepines; Benzimidazoles; Capsid Proteins; CRISPR-Associated Protein 9; CRISPR-Associated Proteins; CRISPR-Cas Systems; Cytomegalovirus; E1A-Associated p300 Protein; Enzyme Inhibitors; HEK293 Cells; Humans; Hydantoins; Interleukin 1 Receptor Antagonist Protein; Isoxazoles; Protein Domains; Recombinant Fusion Proteins; RNA, Guide, Kinetoplastida; Spiro Compounds; Streptococcus pyogenes; Transcription, Genetic; Transcriptional Activation; Triazoles | 2018 |
Synthesis and biological evaluation of novel flavone/triazole/benzimidazole hybrids and flavone/isoxazole-annulated heterocycles as antiproliferative and antimycobacterial agents.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Benzimidazoles; Cell Proliferation; Chemistry Techniques, Synthetic; Flavones; Humans; Inhibitory Concentration 50; Isoxazoles; MCF-7 Cells; Microbial Sensitivity Tests; Triazoles | 2018 |
Facile and highly diastereo and regioselective synthesis of novel octahydroacridine-isoxazole and octahydroacridine-1,2,3-triazole molecular hybrids from citronella essential oil.
Topics: Acridines; Alkynes; Catalysis; Copper; Cycloaddition Reaction; Cymbopogon; Isoxazoles; Oils, Volatile; Triazoles | 2019 |
Synthesis and SAR of new isoxazole-triazole bis-heterocyclic compounds as analogues of natural lignans with antiparasitic activity.
Topics: Antiprotozoal Agents; Carbon-13 Magnetic Resonance Spectroscopy; Drug Evaluation, Preclinical; Heterocyclic Compounds; Humans; Isoxazoles; Leishmania; Lignans; NADH, NADPH Oxidoreductases; Proton Magnetic Resonance Spectroscopy; Spectrophotometry, Infrared; Structure-Activity Relationship; THP-1 Cells; Triazoles; Trypanosoma cruzi | 2018 |
Sea Urchin Embryo Model As a Reliable in Vivo Phenotypic Screen to Characterize Selective Antimitotic Molecules. Comparative evaluation of Combretapyrazoles, -isoxazoles, -1,2,3-triazoles, and -pyrroles as Tubulin-Binding Agents.
Topics: Animals; Antimitotic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Embryo, Nonmammalian; Humans; Isoxazoles; Pyrazoles; Pyrroles; Sea Urchins; Structure-Activity Relationship; Triazoles; Tubulin; Tubulin Modulators | 2018 |
APX001 and Other Gwt1 Inhibitor Prodrugs Are Effective in Experimental
Topics: Aminopyridines; Amphotericin B; Animals; Antifungal Agents; Coccidioides; Disease Models, Animal; Female; Fluconazole; Isoxazoles; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Pneumonia; Prodrugs; Triazoles | 2019 |
CREBBP/EP300 Bromodomain Inhibition Affects the Proliferation of AR-Positive Breast Cancer Cell Lines.
Topics: Androgens; Azepines; Benzimidazoles; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; CREB-Binding Protein; Down-Regulation; E1A-Associated p300 Protein; Female; Gene Expression Regulation, Neoplastic; Humans; Isoxazoles; Protein Domains; Receptors, Androgen; Triazoles | 2019 |
Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.
Topics: Animals; Antifungal Agents; Candida albicans; Cell Line; Drug Resistance, Fungal; Fungal Proteins; Heterocyclic Compounds, 4 or More Rings; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Mice; Models, Molecular; Molecular Chaperones; Protein Binding; Protein Conformation; Protein Domains; Recombinant Proteins; Resorcinols; Signal Transduction; Triazoles; Virulence | 2019 |
Effect of isoxazole derivatives of tetrahydrofuran neolignans on intracellular amastigotes of Leishmania (Leishmania) amazonensis: A structure-activity relationship comparative study with triazole-neolignan-based compounds.
Topics: Animals; Antiprotozoal Agents; Drug Design; Female; Furans; Inhibitory Concentration 50; Isoxazoles; Leishmania; Life Cycle Stages; Lignans; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Nitric Oxide; Structure-Activity Relationship; Triazoles | 2019 |
Location and Cell-Type-Specific Bias of Metabotropic Glutamate Receptor, mGlu
Topics: Allosteric Regulation; Animals; Animals, Newborn; Brain; Cells, Cultured; HEK293 Cells; Humans; Indoles; Isoxazoles; Rats; Receptor, Metabotropic Glutamate 5; Triazoles | 2019 |
How well can a large number of polysomnography sleep measures predict subjective sleep quality in insomnia patients?
Topics: Age Factors; Analgesics; Azepines; Female; Humans; Isoxazoles; Male; Middle Aged; Polysomnography; Predictive Value of Tests; Sleep Aids, Pharmaceutical; Sleep Hygiene; Sleep Initiation and Maintenance Disorders; Time Factors; Triazoles | 2020 |
Design, synthesis and evaluation of novel levoglucosenone derivatives as promising anticancer agents.
Topics: Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Glucose; Humans; Isoxazoles; Molecular Structure; Structure-Activity Relationship; Triazoles | 2020 |
Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells.
Topics: Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Cycle; Cell Line, Tumor; Cellular Senescence; DNA Damage; Fibroblasts; Head and Neck Neoplasms; Humans; Isoxazoles; Male; Protein Kinase Inhibitors; Pyrazines; Pyridines; Quinolines; Radiation, Ionizing; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; TOR Serine-Threonine Kinases; Triazoles | 2020 |
Heat Shock Protein 90 Inhibitor Effects on Pancreatic Cancer Cell Cultures.
Topics: Adenosine Triphosphatases; Antineoplastic Agents; Benzamides; Benzoquinones; Carcinoma, Pancreatic Ductal; Cell Culture Techniques, Three Dimensional; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; HSP90 Heat-Shock Proteins; Humans; Isoindoles; Isoxazoles; Lactams, Macrocyclic; Molecular Structure; Pancreatic Neoplasms; Resorcinols; Rifabutin; Triazoles | 2021 |
Evolution of kinase polypharmacology across HSP90 drug discovery.
Topics: Binding Sites; Discoidin Domain Receptor 1; Drug Discovery; Evolution, Molecular; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Molecular Docking Simulation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Resorcinols; Triazoles | 2021 |
Glioblastoma-specific anticancer activity of newly synthetized 3,5-disubstituted isoxazole and 1,4-disubstituted triazole-linked tyrosol conjugates.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Glioblastoma; Humans; Isoxazoles; Molecular Structure; Phenylethyl Alcohol; Structure-Activity Relationship; Triazoles; Tumor Cells, Cultured | 2021 |
Kinase Inhibitors of DNA-PK, ATM and ATR in Combination with Ionizing Radiation Can Increase Tumor Cell Death in HNSCC Cells While Sparing Normal Tissue Cells.
Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma, Squamous Cell; Cell Death; Cell Line, Tumor; Cells, Cultured; DNA Repair; DNA-Activated Protein Kinase; Head and Neck Neoplasms; Humans; Isoxazoles; Protein Kinase Inhibitors; Pyrazines; Pyridines; Quinolines; Triazoles; X-Rays | 2021 |
Synthesis and biological studies of new piperidino-1,2,3-triazole hybrids with 3-aryl isoxazole side chains.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Isoxazoles; Models, Molecular; Molecular Structure; Piperidines; Structure-Activity Relationship; Triazoles | 2021 |
Profiling the regulatory interplay of BET bromodomains and Sirtuins in cancer cell lines.
Topics: Azepines; Benzazepines; Benzodiazepines; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Humans; Isoxazoles; Proteins; Sirtuins; Transcription Factors; Triazoles | 2022 |
Discovery of Novel Sphingosine-1-Phosphate-1 Receptor Agonists for the Treatment of Multiple Sclerosis.
Topics: Animals; beta-Arrestins; Dogs; Drug Design; Encephalomyelitis, Autoimmune, Experimental; Heart Rate; Humans; Isoxazoles; Lymphocyte Count; Lymphocytes; Male; Mice; Multiple Sclerosis; Rats; Sphingosine-1-Phosphate Receptors; Structure-Activity Relationship; Triazoles | 2022 |
Acid-Switchable Synthesis of Trifluoromethylated Triazoles and Isoxazoles via Reaction of CF
Topics: Acids; Catalysis; Isoxazoles; Triazoles | 2022 |
Discovery of novel triazoles containing benzyloxy phenyl isoxazole side chain with potent and broad-spectrum antifungal activity.
Topics: Antifungal Agents; Candida albicans; Cryptococcus neoformans; Humans; Isoxazoles; Microbial Sensitivity Tests; Structure-Activity Relationship; Triazoles | 2023 |
Electrochemical Synthesis of New Isoxazoles and Triazoles Tethered with Thiouracil Base as Inhibitors of Histone Deacetylases in Human Breast Cancer Cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Isoxazoles; Structure-Activity Relationship; Triazoles | 2023 |