| Condition | Indicated | Relationship Strength | Studies | Trials |
|---|
Chronic Lung Injury
[description not available] | 0 | 2.15 | 1 | 0 |
Disease Exacerbation
[description not available] | 0 | 7.28 | 4 | 4 |
Arteriosclerosis, Coronary
[description not available] | 0 | 5.36 | 2 | 2 |
Diabetes Mellitus, Adult-Onset
[description not available] | 0 | 7.74 | 8 | 5 |
Diabetic Glomerulosclerosis
[description not available] | 0 | 4.8 | 2 | 1 |
Blood Pressure, High
[description not available] | 0 | 6.65 | 5 | 4 |
Albuminuria
The presence of albumin in the urine, an indicator of KIDNEY DISEASES. | 0 | 9.8 | 2 | 1 |
Coronary Artery Disease
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause. | 0 | 5.36 | 2 | 2 |
Diabetes Mellitus, Type 2
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY. | 1 | 9.74 | 8 | 5 |
Diabetic Nephropathies
KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE. | 0 | 4.8 | 2 | 1 |
Hypertension
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. | 1 | 8.65 | 5 | 4 |
Hypertriglyceridemia
A condition of elevated levels of TRIGLYCERIDES in the blood. | 1 | 14.7 | 29 | 8 |
Cardiometabolic Syndrome
A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components not only include metabolic dysfunctions of METABOLIC SYNDROME but also HYPERTENSION, and ABDOMINAL OBESITY. | 0 | 5.5 | 5 | 1 |
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. | 0 | 3.9 | 2 | 1 |
Cancer of Prostate
[description not available] | 0 | 2.17 | 1 | 0 |
Prostatic Neoplasms
Tumors or cancer of the PROSTATE. | 0 | 2.17 | 1 | 0 |
Metabolic Syndrome
A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome include ABDOMINAL OBESITY; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. | 1 | 7.5 | 5 | 1 |
Acute Edematous Pancreatitis
[description not available] | 0 | 2.21 | 1 | 0 |
Complications, Pregnancy
[description not available] | 0 | 2.48 | 2 | 0 |
Carbohydrate Inducible Hyperlipemia
[description not available] | 0 | 2.48 | 2 | 0 |
Hyperlipoproteinemia Type IV
A hypertriglyceridemia disorder, often with autosomal dominant inheritance. It is characterized by the persistent elevations of plasma TRIGLYCERIDES, endogenously synthesized and contained predominantly in VERY-LOW-DENSITY LIPOPROTEINS (pre-beta lipoproteins). In contrast, the plasma CHOLESTEROL and PHOSPHOLIPIDS usually remain within normal limits. | 0 | 2.48 | 2 | 0 |
Pancreatitis
INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis. | 0 | 2.21 | 1 | 0 |
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. | 0 | 2.48 | 2 | 0 |
Breast Cancer
[description not available] | 0 | 7.06 | 6 | 5 |
Breast Neoplasms
Tumors or cancer of the human BREAST. | 1 | 9.06 | 6 | 5 |
Obesity
A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY). | 0 | 7.17 | 5 | 4 |
Insulin Sensitivity
[description not available] | 0 | 7.62 | 4 | 3 |
Weight Reduction
[description not available] | 0 | 3 | 1 | 0 |
Insulin Resistance
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS. | 1 | 9.62 | 4 | 3 |
Weight Loss
Decrease in existing BODY WEIGHT. | 0 | 3 | 1 | 0 |
Anxiety
Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS. | 0 | 4.39 | 1 | 1 |
Depression
Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders. | 0 | 5.79 | 2 | 2 |
Arterial Diseases, Carotid
[description not available] | 0 | 6.32 | 4 | 2 |
Innate Inflammatory Response
[description not available] | 0 | 5.85 | 4 | 2 |
Carotid Artery Diseases
Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology. | 0 | 6.32 | 4 | 2 |
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. | 1 | 7.85 | 4 | 2 |
Endotoxemia
A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators. | 0 | 3.48 | 1 | 1 |
Dyslipidemia
[description not available] | 0 | 5.47 | 5 | 3 |
Dyslipidemias
Abnormalities in the serum levels of LIPIDS, including overproduction or deficiency. Abnormal serum lipid profiles may include high total CHOLESTEROL, high TRIGLYCERIDES, low HIGH DENSITY LIPOPROTEIN CHOLESTEROL, and elevated LOW DENSITY LIPOPROTEIN CHOLESTEROL. | 0 | 5.47 | 5 | 3 |
Angina Pectoris, Stable
[description not available] | 0 | 3.47 | 1 | 1 |
Angina, Stable
Persistent and reproducible chest discomfort usually precipitated by a physical exertion that dissipates upon cessation of such an activity. The symptoms are manifestations of MYOCARDIAL ISCHEMIA. | 0 | 3.47 | 1 | 1 |
Fatty Liver, Nonalcoholic
[description not available] | 0 | 7.54 | 4 | 4 |
Cirrhosis, Liver
[description not available] | 0 | 4.4 | 1 | 1 |
Liver Cirrhosis
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules. | 0 | 4.4 | 1 | 1 |
Non-alcoholic Fatty Liver Disease
Fatty liver finding without excessive ALCOHOL CONSUMPTION. | 1 | 9.54 | 4 | 4 |
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. | 0 | 2.51 | 2 | 0 |
Chronic Kidney Failure
[description not available] | 0 | 5.94 | 5 | 5 |
Kidney Failure, Chronic
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION. | 0 | 5.94 | 5 | 5 |
Benign Neoplasms
[description not available] | 0 | 8.14 | 5 | 5 |
Cardiovascular Diseases
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM. | 1 | 14.5 | 21 | 17 |
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. | 0 | 8.14 | 5 | 5 |
Chronic Kidney Diseases
[description not available] | 0 | 5.12 | 3 | 3 |
Complication, Postoperative
[description not available] | 0 | 3.5 | 1 | 1 |
Blood Clot
[description not available] | 0 | 5.55 | 4 | 4 |
Postoperative Complications
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery. | 0 | 3.5 | 1 | 1 |
Thrombosis
Formation and development of a thrombus or blood clot in the blood vessel. | 0 | 5.55 | 4 | 4 |
Renal Insufficiency, Chronic
Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002) | 1 | 7.12 | 3 | 3 |
Graft Occlusion, Vascular
Obstruction of flow in biological or prosthetic vascular grafts. | 0 | 3.51 | 1 | 1 |
Berger Disease
[description not available] | 0 | 6.05 | 6 | 5 |
Glomerulonephritis, IGA
A chronic form of glomerulonephritis characterized by deposits of predominantly IMMUNOGLOBULIN A in the mesangial area (GLOMERULAR MESANGIUM). Deposits of COMPLEMENT C3 and IMMUNOGLOBULIN G are also often found. Clinical features may progress from asymptomatic HEMATURIA to END-STAGE KIDNEY DISEASE. | 1 | 8.05 | 6 | 5 |
Proteinuria
The presence of proteins in the urine, an indicator of KIDNEY DISEASES. | 0 | 5.53 | 4 | 4 |
Behavior Disorders
[description not available] | 0 | 2.11 | 1 | 0 |
Elevated Cholesterol
[description not available] | 0 | 7.69 | 7 | 2 |
Mental Disorders
Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function. | 0 | 2.11 | 1 | 0 |
Hypercholesterolemia
A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population. | 1 | 9.69 | 7 | 2 |
Condition, Preneoplastic
[description not available] | 0 | 4.46 | 2 | 2 |
Hyperplasia
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells. | 0 | 4.46 | 2 | 2 |
Precancerous Conditions
Pathological conditions that tend eventually to become malignant. | 0 | 4.46 | 2 | 2 |
Alloxan Diabetes
[description not available] | 0 | 2.11 | 1 | 0 |
Central Hypothyroidism
[description not available] | 0 | 2.11 | 1 | 0 |
Hypothyroidism
A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction. | 1 | 4.11 | 1 | 0 |
Airflow Obstruction, Chronic
[description not available] | 0 | 4.43 | 1 | 1 |
Asthma, Bronchial
[description not available] | 0 | 4.43 | 1 | 1 |
Experimental Lung Inflammation
Inflammation of any part, segment or lobe, of the lung parenchyma. | 0 | 4.43 | 1 | 1 |
Acute Disease
Disease having a short and relatively severe course. | 0 | 4.43 | 1 | 1 |
Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL). | 0 | 4.43 | 1 | 1 |
Pneumonia
Infection of the lung often accompanied by inflammation. | 0 | 4.43 | 1 | 1 |
Pulmonary Disease, Chronic Obstructive
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA. | 0 | 4.43 | 1 | 1 |
Liver Steatosis
[description not available] | 0 | 4.43 | 1 | 1 |
Fatty Liver
Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS. | 1 | 11.43 | 1 | 1 |
Coronary Heart Disease
[description not available] | 0 | 4.9 | 4 | 2 |
Coronary Disease
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels. | 0 | 4.9 | 4 | 2 |
Apolipoprotein B-100, Familial Defective
[description not available] | 0 | 4.43 | 1 | 1 |
Hyperlipoproteinemia Type II
A group of familial disorders characterized by elevated circulating cholesterol contained in either LOW-DENSITY LIPOPROTEINS alone or also in VERY-LOW-DENSITY LIPOPROTEINS (pre-beta lipoproteins). | 1 | 6.43 | 1 | 1 |
Familial Combined Hyperlipidemia
[description not available] | 0 | 9.37 | 2 | 2 |
Hyperlipidemia, Familial Combined
A type of familial lipid metabolism disorder characterized by a variable pattern of elevated plasma CHOLESTEROL and/or TRIGLYCERIDES. Multiple genes on different chromosomes may be involved, such as the major late transcription factor (UPSTREAM STIMULATORY FACTORS) on CHROMOSOME 1. | 1 | 6.37 | 2 | 2 |
Cardiovascular Stroke
[description not available] | 0 | 8.92 | 10 | 4 |
Myocardial Infarction
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION). | 1 | 15.92 | 10 | 4 |
Recrudescence
[description not available] | 0 | 4.35 | 1 | 1 |
Auricular Fibrillation
[description not available] | 0 | 5.33 | 2 | 2 |
Atrial Fibrillation
Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation. | 1 | 7.33 | 2 | 2 |
Arrhythmia
[description not available] | 0 | 3.85 | 2 | 0 |
Cardiac Failure
[description not available] | 0 | 4.77 | 2 | 1 |
Arrhythmias, Cardiac
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction. | 0 | 3.85 | 2 | 0 |
Heart Failure
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION. | 1 | 6.77 | 2 | 1 |
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. | 0 | 4.13 | 3 | 1 |
HIV Coinfection
[description not available] | 0 | 3.43 | 1 | 1 |
HIV Infections
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS). | 1 | 5.43 | 1 | 1 |
Rupture, Spontaneous
Tear or break of an organ, vessel or other soft part of the body, occurring in the absence of external force. | 0 | 4.76 | 2 | 1 |
Electrocardiogram QT Prolonged
[description not available] | 0 | 3.46 | 1 | 1 |
Cardiac Arrest, Sudden
[description not available] | 0 | 5.99 | 5 | 2 |
Long QT Syndrome
A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME. | 0 | 3.46 | 1 | 1 |
Death, Sudden, Cardiac
Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005) | 0 | 5.99 | 5 | 2 |
Peripheral Arterial Diseases
[description not available] | 0 | 3.46 | 1 | 1 |
Intermittent Claudication
A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE. | 1 | 5.46 | 1 | 1 |
Peripheral Arterial Disease
Lack of perfusion in the EXTREMITIES resulting from atherosclerosis. It is characterized by INTERMITTENT CLAUDICATION, and an ANKLE BRACHIAL INDEX of 0.9 or less. | 1 | 5.46 | 1 | 1 |
Atherogenesis
[description not available] | 0 | 3.46 | 1 | 1 |
Nephrosis
Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secondary complication of other diseases. It is characterized by the NEPHROTIC SYNDROME indicating the presence of PROTEINURIA and HYPOALBUMINEMIA with accompanying EDEMA. | 0 | 3.46 | 1 | 1 |
Atherosclerosis
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA. | 0 | 3.46 | 1 | 1 |
Vascular Calcification
Deposition of calcium into the blood vessel structures. Excessive calcification of the vessels are associated with ATHEROSCLEROTIC PLAQUES formation particularly after MYOCARDIAL INFARCTION (see MONCKEBERG MEDIAL CALCIFIC SCLEROSIS) and chronic kidney diseases which in turn increase VASCULAR STIFFNESS. | 0 | 9.69 | 9 | 9 |
Hyperlipemia
[description not available] | 0 | 2.92 | 1 | 0 |
Hyperlipidemias
Conditions with excess LIPIDS in the blood. | 0 | 2.92 | 1 | 0 |
Carditis
[description not available] | 0 | 3.41 | 1 | 1 |
Myocarditis
Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCYTES, CARDIAC). Manifestations range from subclinical to sudden death (DEATH, SUDDEN). Myocarditis in association with cardiac dysfunction is classified as inflammatory CARDIOMYOPATHY usually caused by INFECTION, autoimmune diseases, or responses to toxic substances. Myocarditis is also a common cause of DILATED CARDIOMYOPATHY and other cardiomyopathies. | 0 | 3.41 | 1 | 1 |
Indigestion
[description not available] | 0 | 2.02 | 1 | 0 |
Dyspepsia
Impaired digestion, especially after eating. | 0 | 2.02 | 1 | 0 |
Adverse Drug Event
[description not available] | 0 | 2.03 | 1 | 0 |
Drug-Related Side Effects and Adverse Reactions
Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals. | 0 | 2.03 | 1 | 0 |
Acute Confusional Senile Dementia
[description not available] | 0 | 2.06 | 1 | 0 |
Cognition Disorders
Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment. | 0 | 2.06 | 1 | 0 |
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57) | 1 | 4.06 | 1 | 0 |