Tourette Syndrome

A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)

Synonym
Tourette Syndrome

Excerpt	Reference
"Gilles de la Tourette Syndrome is a condition combining organic and psychogenic features existing in the interface between two etiologies."	( Pinta, ER, 1977)
"Gilles de la Tourette syndrome is a neuropsychiatric disease with a childhood onset below age 16, characterized by chronic involuntary movements, obsessions, compulsions, utterances, echolalia, coprolalia and aggressive behavior symptoms."	( Yaryura-Tobias, JA, 1979)
"Tourette syndrome is a neuropsychiatric disorder of motor and vocal tics, with associated symptoms of obsessive-compulsive behaviors and attention deficit disorder with hyperactivity."	( Minderaa, RB, 1987)
"The Gilles de la Tourette syndrome is a disorder whose etiology and pathogenesis are little understood."	( Evans, K; Lascelles, P; Robertson, M; Robinson, A; Trimble, M, 1987)
"Gilles de la Tourette syndrome is frequently associated with symptoms characteristic of hyperactivity and often goes unrecognized for long periods of time."	( Sleator, EK, 1980)
"Gilles de la Tourette syndrome is characterized by (a) onset usually in childhood and adolescence between 2 and 15 years of age, (b) violent facial tics and coprolalia, (c) increased excitability and apathy, (d) progressive increase in the intensity of symptoms, and (e) a chronic course."	( Johnson, FY, 1995)
"Tourette Syndrome is a familial neurobehavioral disorder characterized by fluctuating involuntary motor and/or vocal tics."	( Awaad, Y, 1999)
"Tourette syndrome is defined and characterized mainly by the presence of motor and phonic tics."	( Kessler, AR, 2004)
"Tardive Tourette syndrome is an extrapyramidal symptom which appears after long-term neuroleptic use."	( Ohmori, T; Yamauchi, K, 2006)
"Tourette syndrome is a neurodevelopmental disorder characterized by motor and vocal tics--rapid, repetitive, stereotyped movements or vocalizations."	( Bloch, MH; King, RA; Leckman, JF; Scahill, L, 2006)
"Tourette syndrome is a neuropsychiatric disorder characterized by motor and vocal tics, attentional deficit, poor control of impulses and obsessive compulsive disorder."	( Castiglioni T, C; Miranda C, M, 2007)
"Gilles de la Tourette syndrome is a clinically heterogeneous disorder with poor known pathophysiology."	( Benali, H; Hartmann, A; Lehéricy, S; Malherbe, C; Messé, A; Pélégrini-Issac, M; Vidailhet, M; Worbe, Y, 2012)
"Tourette syndrome is characterized by co-occurring neurobehavioral and other health conditions, and poorer health, education, and family relationships."	( Bitsko, RH; Blumberg, SJ; Ghandour, RM; Holbrook, JR; Mink, JW; Visser, SN; Zinner, SH, 2014)
"Tourette syndrome is a neuropsychiatric disorder characterized by tics."	( Bäumer, T; Feldheim, J; Ganos, C; Gerloff, C; Haggard, P; Kahl, U; Kühn, S; Münchau, A; Roessner, V; Schunke, O; Thomalla, G, 2014)
"Tourette syndrome is a heritable neurodevelopmental disorder whose pathophysiology remains unknown."	( de Leeuw, C; Goudriaan, A; Mathews, CA; Posthuma, D; Scharf, JM; Smit, AB; Verheijen, MH; Yu, D, 2015)
"Gilles de la Tourette syndrome is a hereditary, neuropsychiatric movement disorder with reported abnormalities in the neurotransmission of dopamine and γ-aminobutyric acid (GABA)."	( Anwander, A; García-García, I; Gerasch, S; Kanaan, AS; Lampe, L; Möller, HE; Müller-Vahl, K; Near, J; Pampel, A, 2017)
"Tourette syndrome is a neurodevelopmental disorder, characterized by motor and phonic tics."	( Bouyagoub, S; Critchley, HD; Garfinkel, SN; Gould van Praag, CD; Harrison, NA; Nagai, Y; Parkinson, J; Polyanska, L; Rae, CL; Seth, AK, 2018)
"Tourette syndrome is a neurodevelopmental disorder putatively associated with a hyperdopaminergic state."	( Baldermann, JC; Fischer, AG; Gruendler, TOJ; Huys, D; Kuhn, J; Schüller, T; Ullsperger, M, 2020)
"Gilles de la Tourette syndrome is a multifaceted neurodevelopmental disorder characterized by multiple motor and vocal tics."	( Bäumer, T; Beste, C; Conte, G; Kleimaker, M; Münchau, A; Onken, R; Takacs, A; Verrel, J, 2020)
"Tourette syndrome is a neurodevelopmental disorder characterized by childhood onset of motor and phonic tics; treatments for tics are associated with safety concerns."	( Alexander, J; Barkay, H; Claassen, DO; Coffey, B; Garofalo, EA; Gertz, BJ; Gordon, MF; Harary, E; Jankovic, J; Jimenez-Shahed, J; Savola, JM; Stamler, DA; Wieman, M, 2021)
"Tourette syndrome is a neurodevelopmental disorder characterized by childhood onset of motor and phonic tics, often accompanied by behavioral and psychiatric comorbidities."	( Alexander, JK; Barkay, H; Claassen, DO; Coffey, B; Garofalo, EA; Gertz, BJ; Gordon, MF; Harary, E; Jankovic, J; Jimenez-Shahed, J; Savola, JM; Stamler, DA; Wieman, M, 2021)
"Tourette syndrome is a childhood-onset neuropsychiatric disorder characterized by intrusive motor and vocal tics that can lead to self-injury and deleterious mental health complications."	( Bennet, KE; Blaha, CD; Goyal, A; Jang, DP; Lee, KH; Oh, Y; Rojas-Cabrera, J; Rusheen, AE; Shin, H; Yuen, J, 2023)

Excerpt	Reference
"Tourette syndrome has recently been brought to public attention through popular media."	( Bauer, AM; Shea, TM, 1984)
"Previous studies in Tourette syndrome have reported lateralized abnormalities of neurotransmitters and microstructure of the cortico-striato-thalamo-cortical circuit."	( Behen, ME; Chugani, HT; Juhász, C; Makki, MI; Muzik, O; Saporta, AS; Wilson, BJ, 2010)
"Research in Tourette syndrome has traditionally focused on the motor system."	( Bäumer, T; Beste, C; Conte, G; Kleimaker, M; Münchau, A; Onken, R; Takacs, A; Verrel, J, 2020)

Excerpt	Reference
"This paper describes an attempt to treat Gilles de la Tourette syndrome (GTS) in a severely mentally handicapped girl, using a cue-controlled relaxation technique."	( Crawley, B; Locke, J; Zarkowska, E, 1989)
"Alternate medications for the treatment of Tourette syndrome are required because haloperidol in some patients either may be ineffective or may cause disturbing side effects."	( Camp, JA; Cohen, S; Sverd, J, 1983)
"Emerging behavioral treatments of Tourette syndrome are based in part on an understanding of the moment-to-moment experience of somatosensory urges and motor response."	( Bloch, MH; King, RA; Leckman, JF; Scahill, L, 2006)
"Food and Drug Administration for treatment of Tourette syndrome (TS), but their potential side effects, which include tardive dyskinesia (TD), limit their use."	( Jankovic, J; Wijemanne, S; Wu, LJ, 2014)
"Current pharmacological treatments for Tourette Syndrome (TS), such as antipsychotic agents and α-2 agonists, are moderately effective in the treatment of tics, but have substantial side effects that limit their use."	( Alvarenga, PG; Bloch, MH; Jakubovski, E; Landeros-Weisenberger, A; Leckman, JF; Mulqueen, JM; Panza, KE; Yaffa, A, 2016)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	469 (36.78)	23.3326
1990's	266 (20.86)	12.5806
2000's	276 (21.65)	18.1394
2010's	207 (16.24)	28.8240
2020's	57 (4.47)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	medium	31	1
5-hydroxytryptophan	low	4	0
adenine	low	1	0
choline	low	11	0
chlorine	low	1	0
salicylic acid	medium	3	1
bupropion	low	2	0
3,4-dihydroxyphenylacetic acid	low	3	0
creatine	low	2	0
glycine	low	1	0
histamine	low	11	0
hydrogen	low	1	0
indoleacetic acid	low	1	0
iodine	low	1	0
dihydroxyphenylalanine	low	3	0
kynurenine	low	3	0
inositol	low	1	0
melatonin	medium	3	1
phenylacetic acid	low	1	0
phenethylamine	low	4	0
pteridines	low	1	0
pyridoxine	low	2	0
tryptamine	low	2	0
uric acid	low	2	0
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid	low	1	0
sk&f 82958	low	1	0
4-iodo-2,5-dimethoxyphenylisopropylamine	low	6	0
normetanephrine	low	3	0
sk&f-38393	medium	2	1
vanilmandelic acid	low	1	0
pk 11195	low	1	0
1-(3-chlorophenyl)piperazine	medium	1	1
3-methoxytyramine	low	1	0
homovanillic acid	medium	32	1
phenytoin	low	1	0
hydroxyindoleacetic acid	medium	19	1
amantadine	medium	5	2
dan 2163	low	5	0
amitriptyline	low	2	0
amobarbital	low	1	0
aspirin	low	1	0
baclofen	medium	2	2
benserazide	low	1	0
berberine	medium	1	1
biperiden	low	2	0
buspirone	low	1	0
caffeine	low	1	0
verapamil	low	2	0
carbamazepine	low	6	0
celecoxib	low	1	0
chlordiazepoxide	low	1	0
chlorpromazine	medium	19	1
ciprofloxacin	low	1	0
citalopram	medium	4	1
clomipramine	medium	27	1
clonazepam	low	12	0
clonidine	medium	113	19
cyproheptadine	low	1	0
debrisoquin	low	4	0
desipramine	medium	10	2
amphetamine	medium	15	2
diazepam	medium	4	1
valproic acid	low	5	0
p-chloroamphetamine	low	1	0
donepezil	low	4	0
doxepin	low	1	0
droperidol	low	1	0
fenfluramine	low	1	0
fluphenazine	medium	11	4
flumazenil	low	1	0
fluoxetine	medium	25	6
flutamide	medium	2	2
imipramine	low	10	0
isocarboxazid	low	1	0
ketanserin	medium	3	1
lamotrigine	low	5	0
lansoprazole	low	1	0
lorazepam	low	2	0
loxapine	low	2	0
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one	low	1	0
mecamylamine	medium	8	3
mesoridazine	low	1	0
metformin	low	1	0
methadone	low	3	0
methylphenidate	medium	46	8
metoclopramide	medium	6	3
mitoxantrone	low	1	0
nefazodone	low	1	0
nifedipine	medium	4	1
nortriptyline	low	2	0
ofloxacin	low	1	0
ondansetron	medium	3	2
orphenadrine	medium	1	1
oxidopamine	low	1	0
oxybutynin	medium	1	1
pemoline	low	10	0
perphenazine	low	3	0
phenindione	low	1	0
phenobarbital	low	2	0
piracetam	medium	6	4
pirenzepine	medium	10	4
piribedil	medium	3	1
primidone	low	1	0
probenecid	low	2	0
procyclidine	low	1	0
promethazine	low	2	0
propranolol	medium	7	1
riluzole	medium	2	1
ropinirole	medium	1	1
spiperone	low	1	0
sulpiride	low	15	0
talipexole	medium	1	1
thiethylperazine	low	1	0
thioridazine	low	9	0
thiothixene	low	1	0
trifluoperazine	medium	7	2
trifluperidol	low	1	0
triflupromazine	low	1	0
trihexyphenidyl	low	5	0
trimipramine	low	1	0
corticosterone	low	1	0
prednisolone	low	2	0
lysergic acid diethylamide	low	1	0
reserpine	low	3	0
thyroxine	low	3	0
dextroamphetamine	medium	22	3
prednisone	low	1	0
pentylenetetrazole	low	1	0
triiodothyronine	low	1	0
serine	medium	1	1
aspartic acid	low	1	0
glutamine	low	6	0
physostigmine	medium	6	1
apomorphine	medium	9	1
carbostyril	medium	38	7
tyrosine	low	3	0
methionine	low	2	0
phenylalanine	low	2	0
histidine	low	1	0
valine	low	6	0
tryptophan	medium	17	1
propane	low	1	0
methylprednisolone	low	2	0
quinoxalines	low	1	0
pyrrolidonecarboxylic acid	medium	1	1
propionitrile	low	1	0
deanol	medium	3	1
3,3'-iminodipropionitrile	low	6	0
ergotamine	low	1	0
1-naphthylamine	medium	4	1
yohimbine	low	1	0
isoxazoles	low	7	0
thiazoles	medium	12	4
citrulline	low	1	0
cyproterone acetate	low	1	0
dextropropoxyphene	medium	1	1
bicuculline	low	2	0
indophenol	low	3	0
methoxyhydroxyphenylglycol	medium	18	1
malondialdehyde	low	1	0
lithium carbonate	medium	6	1
erythromycin	low	2	0
4-amino-3-phenylbutyric acid	low	1	0
pyrithioxin	low	1	0
s,n,n'-tripropylthiocarbamate	medium	13	3
methionine sulfoximine	low	1	0
benperidol	low	1	0
flupenthixol	medium	1	1
fluorine	low	1	0
calcium pyrophosphate	low	1	0
trolamine salicylate	low	1	0
selegiline	medium	6	1
pregnanolone	low	3	0
4-methoxyamphetamine	low	1	0
glutamic acid	low	13	0
torpedo	low	1	0
penfluridol	low	1	0
tramadol	low	2	0
substance p	low	2	0
diltiazem	low	1	0
paroxetine	medium	4	1
progabide	low	1	0
pergolide	medium	5	3
fomesafen	medium	5	2
quinpirole	low	1	0
atomoxetine hydrochloride	medium	12	2
spiradoline	medium	2	1
finasteride	medium	4	1
naxagolide	low	2	0
ziprasidone	medium	12	4
glucose, (beta-d)-isomer	low	7	0
n-acetylaspartic acid	low	1	0
cephalosporin c	low	1	0
triazoles	low	1	0
fluorodeoxyglucose f18	low	8	0
sertraline	medium	11	1
tianeptine	low	1	0
clarithromycin	low	2	0
nicotine	medium	30	5
phenylacetylglutamine	low	1	0
vitamin b 6	medium	4	3
(3h)2-carbomethoxy-3-(4-fluorophenyl)tropane	low	1	0
3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide	low	3	0
dynorphin (1-8)	low	2	0
deoxyglucose	low	5	0
gastrodin	low	6	0
3-n-methylspiperone	low	1	0
ro 22-1319	medium	3	2
tryptophan methyl ester	low	1	0
ro 8-0576	low	1	0
dihydrotetrabenazine	low	3	0
blonanserin	low	1	0
dexmethylphenidate hydrochloride	medium	1	1
rhodioloside	low	1	0
6-hydroxytryptamine	low	1	0
asenapine	low	1	0
atropine	low	2	0
1-testosterone	low	1	0
benzofurans	low	1	0
ritonavir	low	1	0
oxytocin	low	2	0
theanine	medium	1	1
inositol 1,4,5-trisphosphate	low	1	0
inositol 3-phosphate	low	3	0
pentazocine	low	1	0
diprenorphine	low	1	0
tretinoin	low	1	0
cocaine	low	11	0
zithromax	low	1	0
aphidicolin	low	2	0
enkephalin, leucine	low	1	0
riboflavin	low	1	0
buprenorphine	low	1	0
arginine vasopressin	low	1	0
leuprolide	low	1	0
alpha-methyltryptophan, (l)-isomer	low	1	0
cotinine	medium	1	1
flunarizine	medium	1	1
benztropine	medium	9	4
enclomiphene	low	3	0
D-fructopyranose	medium	5	1
digoxin	low	1	0
rhyncophylline	low	3	0
lithium	medium	17	3
altanserin	low	1	0
raclopride	medium	6	1
sch 23390	low	1	0
2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline	low	1	0
6-cyano-7-nitroquinoxaline-2,3-dione	low	1	0
17-ketosteroids	low	1	0
am 281	low	1	0
myelin basic protein	low	2	0
humulene	low	6	0
anandamide	low	1	0
codeine	low	4	0
levetiracetam	medium	6	4
naloxone	medium	14	1
oxycodone	low	3	0
morphine	low	2	0
deamino arginine vasopressin	low	1	0
mdl 100907	low	1	0
fluvoxamine	medium	11	3
levorphanol	low	1	0
naltrexone	medium	7	1
indinavir sulfate	low	1	0
methylazoxymethanol acetate	low	1	0
cysteine	low	2	0
heroin	low	1	0
pregabalin	low	1	0
tiapridex	medium	2	1
dizocilpine maleate	low	1	0
antimycin a	low	1	0
dolichols	low	1	0
tiapamil hydrochloride	medium	9	3
stepholidine	medium	1	1
delta9-tetrahydrocannabinol hemisuccinate	low	1	0
paliperidone palmitate	low	3	0
flb 457	low	1	0
pitolisant	low	1	0
g(m1) ganglioside	low	1	0
n-((1-allyl-2-pyrrolidinyl)methyl)-5-(3-fluoropropyl)-2,3-dimethoxybenzamide	low	1	0
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane	low	1	0
technetium tc 99m exametazime	medium	7	1
scopolamine hydrobromide	medium	3	1
acid phosphatase	low	1	0
jaw	low	1	0
dynorphins	medium	6	1
beta-endorphin	low	1	0
phosphatidylcholines	low	8	0
ro13-9904	low	1	0
quetiapine fumarate	medium	15	2
neurotensin	low	1	0
gw 1000	medium	4	1
piperidines	low	12	0
interleukin-8	low	1	0
minocycline	low	1	0
warfarin	low	1	0
phenprocoumon	low	1	0
daptomycin	low	1	0
exudates	low	1	0
acyclovir	low	1	0
guanine	low	2	0
inosine	medium	1	1
neopterin	low	2	0
clozapine	medium	13	1
olanzapine	medium	17	6
eye	low	1	0
carbidopa	medium	3	1
ego	low	4	0
technetium tc 99m bicisate	low	2	0

Protein Targets (1,712)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Sodium-dependent serotonin transporter	0	66	8	75
Sodium-dependent dopamine transporter	0	51	6	57
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	27	0	0	27
5-hydroxytryptamine receptor 3E	0	8	2	11
acetylcholinesterase	35	0	0	35
TDP1 protein	95	0	0	95
cytochrome P450 2D6	64	0	0	64
v-jun sarcoma virus 17 oncogene homolog (avian)	38	0	0	38
cytochrome P450 2D6 isoform 1	43	0	0	43
cellular tumor antigen p53 isoform a	20	0	0	20
cytochrome P450 2C19 precursor	26	0	0	26
cytochrome P450 2C9 precursor	24	0	0	24
thyroid hormone receptor beta isoform a	22	0	0	22
thyroid hormone receptor beta isoform 2	68	0	0	68
huntingtin isoform 2	13	0	0	13
peripheral myelin protein 22	46	0	0	46
cytochrome P450 3A4 isoform 1	46	0	0	46
muscarinic acetylcholine receptor M1	47	0	0	47
Gamma-aminobutyric acid receptor subunit pi	46	20	4	70
Polyunsaturated fatty acid lipoxygenase ALOX15B	26	0	0	26
ATP-binding cassette sub-family C member 3	0	73	0	73
Multidrug resistance-associated protein 4	0	73	0	73
5-hydroxytryptamine receptor 3B	0	8	2	11
Bile salt export pump	0	109	0	109
Beta-1 adrenergic receptor	0	6	1	7
5-hydroxytryptamine receptor 1A	0	27	14	41
5-hydroxytryptamine receptor 2C	0	45	8	53
D(2) dopamine receptor	0	83	13	106
5-hydroxytryptamine receptor 2A	0	52	11	63
Gamma-aminobutyric acid receptor subunit beta-1	46	20	4	70
Alpha-1B adrenergic receptor	0	49	5	54
Gamma-aminobutyric acid receptor subunit delta	46	20	4	70
Gamma-aminobutyric acid receptor subunit gamma-2	46	20	6	72
D	0	39	0	42
5-hydroxytryptamine receptor 1A	0	70	8	79
Gamma-aminobutyric acid receptor subunit alpha-5	46	20	4	70
Gamma-aminobutyric acid receptor subunit alpha-3	46	20	4	70
Gamma-aminobutyric acid receptor subunit gamma-1	46	20	4	70
Gamma-aminobutyric acid receptor subunit alpha-2	46	20	4	70
Alpha-1D adrenergic receptor	0	38	5	43
5-hydroxytryptamine receptor 2A	0	84	10	99
5-hydroxytryptamine receptor 2C	0	79	5	85
Gamma-aminobutyric acid receptor subunit alpha-4	46	20	4	70
Gamma-aminobutyric acid receptor subunit gamma-3	46	20	4	70
5-hydroxytryptamine receptor 1B	0	55	5	60
5-hydroxytryptamine receptor 1D	0	21	5	26
Gamma-aminobutyric acid receptor subunit alpha-6	46	20	4	70
5-hydroxytryptamine receptor 1F	0	21	5	26
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 2B	0	43	9	52
5-hydroxytryptamine receptor 7	0	24	6	30
5-hydroxytryptamine receptor 7	0	23	1	24
Alpha-1B adrenergic receptor	0	12	2	15
Glutamate receptor ionotropic, NMDA 1	0	18	3	27
5-hydroxytryptamine receptor 2B	0	75	3	79
Alpha-1A adrenergic receptor	0	60	6	66
5-hydroxytryptamine receptor 3A	0	11	2	14
Histamine H2 receptor	42	6	1	58
5-hydroxytryptamine receptor 6	0	55	1	58
Beta-2 adrenergic receptor	0	2	0	2
D(2) dopamine receptor	0	70	11	86
Gamma-aminobutyric acid receptor subunit alpha-1	46	22	6	74
Gamma-aminobutyric acid receptor subunit beta-3	46	20	4	70
Gamma-aminobutyric acid receptor subunit beta-2	46	20	6	72
Glutamate receptor ionotropic, NMDA 2A	0	18	3	27
Glutamate receptor ionotropic, NMDA 2B	0	19	3	28
Glutamate receptor ionotropic, NMDA 2C	0	19	3	28
Glutamate receptor ionotropic, NMDA 2D	0	18	3	27
5-hydroxytryptamine receptor 3D	0	8	2	11
Glutamate receptor ionotropic, NMDA 3B	0	18	3	27
5-hydroxytryptamine receptor 3C	0	8	2	11
GABA theta subunit	46	20	4	70
Canalicular multispecific organic anion transporter 1	0	74	0	74
Gamma-aminobutyric acid receptor subunit epsilon	46	20	4	70
Glutamate receptor ionotropic, NMDA 3A	0	18	3	27
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	35	0	0	35
Chain A, HADH2 protein	29	0	0	29
Chain B, HADH2 protein	29	0	0	29
RAR-related orphan receptor gamma	59	0	0	59
GLI family zinc finger 3	62	0	0	62
AR protein	82	0	0	82
aldehyde dehydrogenase 1 family, member A1	43	0	0	43
thyroid stimulating hormone receptor	43	0	0	43
estrogen receptor 2 (ER beta)	31	0	0	31
nuclear receptor subfamily 1, group I, member 3	52	0	0	52
progesterone receptor	42	0	0	42
glucocorticoid receptor [Homo sapiens]	62	0	0	62
retinoic acid nuclear receptor alpha variant 1	54	0	0	54
estrogen-related nuclear receptor alpha	67	0	0	67
pregnane X nuclear receptor	56	0	0	56
estrogen nuclear receptor alpha	88	0	0	88
aryl hydrocarbon receptor	31	0	0	31
thyroid stimulating hormone receptor	38	0	0	38
activating transcription factor 6	22	0	0	22
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	28	0	0	28
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	17	0	0	17
nuclear factor erythroid 2-related factor 2 isoform 1	55	0	0	55
Voltage-dependent calcium channel gamma-2 subunit	31	0	0	31
Glutamate receptor 2	33	6	4	45
Kelch-like ECH-associated protein 1	0	0	1	1
Histone acetyltransferase KAT8	0	1	0	1
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-1	0	1	0	1
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-1	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	28	0	0	28
Chain A, Cruzipain	9	0	0	9
Chain A, Methyltransferase Wbdd	0	1	0	1
thioredoxin reductase	60	0	0	60
15-lipoxygenase, partial	20	0	0	20
ATAD5 protein, partial	39	0	0	39
NFKB1 protein, partial	23	0	0	23
Thrombopoietin	18	0	0	18
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	21	0	0	21
regulator of G-protein signaling 4	56	0	0	56
EWS/FLI fusion protein	42	0	0	42
67.9K protein	19	0	0	19
Parkin	8	0	0	8
euchromatic histone-lysine N-methyltransferase 2	106	0	0	106
chromobox protein homolog 1	60	0	0	60
flap endonuclease 1	28	0	0	28
serine/threonine-protein kinase mTOR isoform 1	27	0	0	27
survival motor neuron protein isoform d	25	0	0	25
M-phase phosphoprotein 8	26	0	0	26
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	1	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	0	1	0	1
Serine/threonine-protein kinase PLK4	0	1	0	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	1	0	1
Bromodomain-containing protein 4	0	1	0	1
5-hydroxytryptamine receptor 4	0	62	0	62
cGMP-specific 3',5'-cyclic phosphodiesterase	0	3	0	3
Integrin beta-3	16	3	1	20
Cytochrome P450 1A2	0	12	2	15
Integrin alpha-IIb	16	3	1	20
Neuronal acetylcholine receptor subunit alpha-4	3	12	5	21
Serine/threonine-protein kinase pim-1	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	3	11	5	20
Casein kinase II subunit alpha'	0	2	0	2
Proteinase-activated receptor 1	0	1	1	3
Bromodomain-containing protein 2	0	1	0	1
Phosphatidylinositol 3-kinase regulatory subunit alpha	0	1	0	2
Sodium-dependent serotonin transporter	0	21	4	26
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	2	0	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	1	0	3
Serine/threonine-protein kinase mTOR	0	2	0	2
Serine/threonine-protein kinase mTOR	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	2	0	3
Glycogen synthase kinase-3 beta	0	2	0	2
D(1A) dopamine receptor	19	4	0	23
Serine/threonine-protein kinase PLK1	0	2	0	2
Casein kinase II subunit beta	0	2	0	2
Casein kinase II subunit alpha	0	2	0	2
DNA-dependent protein kinase catalytic subunit	0	4	0	4
Mu-type opioid receptor	0	19	4	24
Serine-protein kinase ATM	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
Serine/threonine-protein kinase ATR	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Bromodomain-containing protein 3	0	1	0	1
Serine/threonine-protein kinase pim-3	0	1	0	1
Phosphoinositide 3-kinase regulatory subunit 5	0	1	0	1
Serine/threonine-protein kinase PLK3	0	2	0	2
Serine/threonine-protein kinase PLK2	0	1	0	1
ATP-dependent phosphofructokinase	50	0	0	50
Chain A, Putative fructose-1,6-bisphosphate aldolase	15	0	0	15
Chain A, ATP-DEPENDENT DNA HELICASE Q1	13	0	0	13
phosphopantetheinyl transferase	37	0	0	37
USP1 protein, partial	39	0	0	39
Microtubule-associated protein tau	38	0	0	38
alpha-galactosidase	7	0	0	7
vitamin D3 receptor isoform VDRA	26	0	0	26
DNA polymerase kappa isoform 1	22	0	0	22
histone acetyltransferase KAT2A isoform 1	27	0	0	27
Metabotropic glutamate receptor 6	0	2	2	5
Glutamate receptor 1	2	6	4	14
Glutamate receptor 3	2	6	4	14
Glutamate receptor 4	2	6	4	14
Glutamate receptor ionotropic, kainate 1	0	6	2	8
Adenosine receptor A1	0	11	0	17
Glutamate receptor ionotropic, kainate 1	0	5	1	6
Glutamate receptor ionotropic, kainate 2	0	6	1	7
Glutamate receptor 1	0	7	2	10
Glutamate receptor 2	0	7	2	10
Glutamate receptor 3	0	6	1	7
Glutamate receptor ionotropic, kainate 3	0	5	0	5
Glutamate receptor 4	0	7	1	9
Glutamate receptor ionotropic, kainate 4	0	5	0	5
Glutamate receptor ionotropic, kainate 2	0	5	1	6
Glutamate receptor ionotropic, kainate 3	0	4	0	4
Glutamate receptor ionotropic, kainate 5	0	5	1	6
D(4) dopamine receptor	0	35	5	47
D(3) dopamine receptor	0	71	9	89
mitogen-activated protein kinase 1	33	0	0	33
Trace amine-associated receptor 1	0	0	5	5
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	17	0	0	17
Chain A, Protocatechuate 3,4-dioxygenase	0	0	1	1
Chain M, Protocatechuate 3,4-dioxygenase	0	0	1	1
Olfactory receptor class A-like protein 1	0	0	2	2
Luciferase	17	0	0	17
endonuclease IV	12	0	0	12
RGS12	1	0	0	1
GLS protein	57	0	0	57
alkaline phosphatase, intestinal	0	0	1	1
thioredoxin glutathione reductase	8	0	0	8
apical membrane antigen 1, AMA1	10	0	0	10
hypothetical protein, conserved	6	0	0	6
Bloom syndrome protein isoform 1	33	0	0	33
lysosomal alpha-glucosidase preproprotein	7	0	0	7
peripheral myelin protein 22 isoform 1	18	0	0	18
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	1	0	1
intestinal alkaline phosphatase precursor	0	1	0	1
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
DNA polymerase beta	8	0	0	8
DNA polymerase iota isoform a (long)	17	0	0	17
geminin	70	0	0	70
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
POsterior Segregation	0	0	3	3
lamin isoform A-delta10	65	0	0	65
Prolyl 4-hydroxylase subunit alpha-1	0	3	0	3
Sodium-dependent noradrenaline transporter	0	65	8	73
Zinc finger protein mex-5	0	0	2	2
Gamma-aminobutyric acid type B receptor subunit 2	0	4	2	6
Gamma-aminobutyric acid type B receptor subunit 1	0	4	2	6
atrial natriuretic peptide receptor 1 precursor	13	0	0	13
5-hydroxytryptamine receptor 6	0	11	5	16
5-hydroxytryptamine receptor 2C	0	5	0	6
5-hydroxytryptamine receptor 2A	0	3	0	4
5-hydroxytryptamine receptor 5A	0	11	5	16
5-hydroxytryptamine receptor 5B	0	11	5	16
5-hydroxytryptamine receptor 3A	0	16	6	22
5-hydroxytryptamine receptor 5A	0	8	0	8
5-hydroxytryptamine receptor 4	0	13	5	19
Ataxin-2	53	0	0	53
5-hydroxytryptamine receptor 3B	0	16	6	22
glucocerebrosidase	11	0	0	11
lethal factor (plasmid)	27	0	0	27
Inositol monophosphatase 1	20	0	0	20
dopamine D1 receptor	14	0	0	14
pregnane X receptor	11	0	0	11
retinoid X nuclear receptor alpha	41	0	0	41
farnesoid X nuclear receptor	32	0	0	32
vitamin D (1,25- dihydroxyvitamin D3) receptor	33	0	0	33
arylsulfatase A	48	0	0	48
D(1A) dopamine receptor	51	0	0	51
heat shock protein beta-1	19	0	0	19
Histone deacetylase 3	0	5	0	5
Solute carrier family 22 member 6	0	4	0	5
Histone deacetylase 4	0	5	0	5
Guanine nucleotide-binding protein G	4	0	0	4
Histone deacetylase 1	0	5	0	5
Histone deacetylase 7	0	5	0	5
Histone deacetylase 2	0	5	0	5
Polyamine deacetylase HDAC10	0	5	0	5
Histone deacetylase 11	0	5	0	5
Histone deacetylase 8	0	5	0	5
Histone deacetylase 6	0	5	0	5
Histone deacetylase 9	0	5	0	5
Histone deacetylase 5	0	5	0	5
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, Ferritin light chain	17	0	0	17
Thymidine kinase	0	1	0	1
Smad3	20	0	0	20
Histone H2A.x	14	0	0	14
hemoglobin subunit beta	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	11	0	0	11
Solute carrier family 22 member 1	0	35	0	41
Bile salt export pump	0	19	0	19
Purine nucleoside phosphorylase	0	3	0	4
Thymidine kinase, cytosolic	0	0	0	1
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2C9	0	31	1	33
Cytochrome P450 2J2	0	23	0	24
Disintegrin and metalloproteinase domain-containing protein 17	9	0	0	9
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	3	0	5
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	4	0	5
Thymidine kinase	0	1	0	1
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
cytochrome P450 family 3 subfamily A polypeptide 4	56	0	0	56
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	39	0	0	39
nuclear factor erythroid 2-related factor 2 isoform 2	23	0	0	23
importin subunit beta-1 isoform 1	8	0	0	8
snurportin-1	8	0	0	8
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	4	0	0	4
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
TAR DNA-binding protein 43	11	1	0	12
Protein mono-ADP-ribosyltransferase PARP15	0	2	0	2
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	24	0	0	24
Glutamate receptor ionotropic, NMDA 2D	0	7	0	7
Glutamate receptor ionotropic, NMDA 3B	0	7	0	7
Glutamate receptor 1	0	1	1	2
Glutamate receptor 2	0	1	0	1
Excitatory amino acid transporter 1	0	4	0	5
Excitatory amino acid transporter 2	0	4	0	5
Excitatory amino acid transporter 3	0	4	0	5
Glutamate receptor ionotropic, NMDA 1	0	7	0	7
Glutamate receptor ionotropic, NMDA 2A	0	7	0	7
Glutamate receptor ionotropic, NMDA 2B	0	7	0	7
Glutamate receptor ionotropic, NMDA 2C	0	7	0	7
Glutamate receptor ionotropic, kainate 4	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	7	0	7
Glutamate receptor 4	0	1	0	1
Glutamate receptor 3	0	1	0	1
nuclear receptor ROR-gamma isoform 1	28	0	0	28
Cannabinoid receptor 1	0	6	2	8
Cannabinoid receptor 1	0	8	1	12
Cannabinoid receptor 2	0	6	2	11
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
putative alpha-glucosidase	1	0	0	1
Solute carrier family 22 member 2	0	14	0	17
Matrix protein 2	0	1	1	2
Matrix protein 2	0	1	2	3
Spike glycoprotein	45	3	7	55
Solute carrier family 22 member 1	0	13	0	17
Multidrug and toxin extrusion protein 1	0	14	0	14
Solute carrier family 22 member 2	0	9	0	12
atrial natriuretic peptide receptor 2 precursor	21	0	0	21
Voltage-dependent L-type calcium channel subunit alpha-1F	0	19	0	19
Albumin	0	0	12	12
High affinity nerve growth factor receptor	0	1	2	3
Aldo-keto reductase family 1 member B1	0	47	0	47
Muscarinic acetylcholine receptor M2	0	49	4	58
Muscarinic acetylcholine receptor M4	0	53	2	58
Muscarinic acetylcholine receptor M1	0	23	1	26
Muscarinic acetylcholine receptor M3	0	20	1	23
Muscarinic acetylcholine receptor M4	0	20	1	23
Muscarinic acetylcholine receptor M5	0	19	1	22
Muscarinic acetylcholine receptor M5	0	50	1	54
Alpha-2A adrenergic receptor	0	62	6	69
Muscarinic acetylcholine receptor M2	0	23	2	28
Muscarinic acetylcholine receptor M1	0	56	5	67
Angiotensin-converting enzyme	0	36	0	36
Alpha-2B adrenergic receptor	0	59	2	62
Alpha-2C adrenergic receptor	0	55	5	61
Muscarinic acetylcholine receptor M3	0	52	3	58
D(1A) dopamine receptor	0	52	8	65
D(1B) dopamine receptor	0	17	1	22
UDP-glucuronosyltransferase 1A4	0	1	0	9
Histamine H2 receptor	0	33	4	37
Alpha-1D adrenergic receptor	0	52	2	55
Histamine H1 receptor	0	15	1	16
Histamine H1 receptor	0	52	7	62
Sodium channel protein type 1 subunit alpha	0	9	0	9
Sodium channel protein type 4 subunit alpha	0	10	0	13
UDP-glucuronosyltransferase 1A3	0	0	0	4
5-hydroxytryptamine receptor 7	0	21	0	21
Voltage-dependent N-type calcium channel subunit alpha-1B	0	8	0	8
Sodium channel protein type 7 subunit alpha	0	7	0	7
Voltage-dependent L-type calcium channel subunit alpha-1D	0	19	0	19
Potassium voltage-gated channel subfamily H member 2	0	76	0	77
Voltage-dependent L-type calcium channel subunit alpha-1S	0	19	0	19
Voltage-dependent L-type calcium channel subunit alpha-1C	0	21	0	22
Sodium channel protein type 5 subunit alpha	0	15	0	15
Sodium channel protein type 9 subunit alpha	0	11	0	11
Sigma non-opioid intracellular receptor 1	0	10	2	12
Nuclear receptor subfamily 3 group C member 3	0	35	0	35
Sodium channel protein type 2 subunit alpha	0	10	0	10
Sigma non-opioid intracellular receptor 1	0	56	1	57
Sodium channel protein type 3 subunit alpha	0	10	0	10
Sodium channel protein type 11 subunit alpha	0	7	0	7
Sodium channel protein type 8 subunit alpha	0	7	0	7
Histamine H3 receptor	0	14	2	17
Sodium channel protein type 10 subunit alpha	0	8	0	8
Solute carrier family 22 member 3	0	3	0	3
Phenylethanolamine N-methyltransferase	0	4	0	4
Cytochrome P450 2A6	0	9	2	11
Substance-P receptor	0	3	0	3
Cytochrome P450 2A5	0	4	0	4
Sodium-dependent dopamine transporter	0	31	2	33
Beta-2 adrenergic receptor	0	5	1	8
Sigma non-opioid intracellular receptor 1	0	13	3	16
Fatty-acid amide hydrolase 1	0	3	0	3
Fatty-acid amide hydrolase 1	0	0	0	1
Potassium channel subfamily K member 3	0	1	0	1
Fatty acid-binding protein, liver	0	3	0	3
Cannabinoid receptor 1	0	2	0	2
Cannabinoid receptor 2	0	2	1	3
Fatty-acid amide hydrolase 1	0	4	0	5
Fatty acid-binding protein 5	0	0	1	1
Corticotropin-releasing factor receptor 2	0	2	0	2
Lanosterol 14-alpha demethylase	0	2	0	2
Potassium channel subfamily K member 2	0	3	0	3
Transient receptor potential cation channel subfamily V member 1	0	1	3	5
Cannabinoid receptor 2	0	3	0	3
Transient receptor potential cation channel subfamily V member 2	0	4	1	5
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase beta	0	1	0	1
DNA polymerase beta	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase alpha catalytic subunit	0	1	1	2
DNA polymerase delta catalytic subunit	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase subunit gamma-1	0	1	0	1
DNA polymerase lambda	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	18	0	0	18
peroxisome proliferator-activated receptor delta	30	0	0	30
peroxisome proliferator activated receptor gamma	36	0	0	36
potassium voltage-gated channel subfamily H member 2 isoform d	45	0	0	45
Cellular tumor antigen p53	48	0	0	48
Tryptophan 5-hydroxylase 1	0	6	0	6
D(3) dopamine receptor	0	33	2	38
Alpha-2B adrenergic receptor	0	26	3	29
D(2) dopamine receptor	0	12	0	12
Alpha-2C adrenergic receptor	0	26	3	29
Alpha-2A adrenergic receptor	0	27	3	30
D(1B) dopamine receptor	0	23	0	23
D(4) dopamine receptor	0	25	1	26
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
D	0	5	0	5
D	0	11	0	11
Translocator protein	0	5	4	10
Vasopressin V2 receptor	0	4	3	8
Oxytocin receptor	0	3	4	7
Vasopressin V1a receptor	0	1	2	3
Vasopressin V1a receptor	0	7	4	11
Vasopressin V1b receptor	0	3	3	6
Vasopressin V2 receptor	0	0	1	1
Vasopressin V1b receptor	0	2	1	4
Translocator protein	0	2	0	3
Oxytocin receptor	0	2	0	2
Vasopressin V2 receptor	0	3	2	5
SMAD family member 2	12	0	0	12
Fumarate hydratase	24	0	0	24
PPM1D protein	14	0	0	14
SMAD family member 3	12	0	0	12
G	33	0	0	33
polyprotein	24	0	0	24
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	9	0	0	9
mu-type opioid receptor isoform MOR-1	0	0	4	4
transcriptional regulator ERG isoform 3	6	0	0	6
5-hydroxytryptamine receptor 2A	0	0	4	4
neuropeptide S receptor isoform A	10	0	0	10
5-hydroxytryptamine receptor 3A	0	2	2	4
Interferon beta	46	0	0	46
HLA class I histocompatibility antigen, B alpha chain	33	0	0	33
ATP-dependent translocase ABCB1	0	33	1	48
Cytochrome P450 3A4	0	37	2	45
Histamine H1 receptor	0	8	3	12
Alpha-1A adrenergic receptor	0	14	3	18
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	5	0	5
Multidrug and toxin extrusion protein 2	0	10	0	10
Inositol hexakisphosphate kinase 1	33	0	0	33
cytochrome P450 2C9, partial	33	0	0	33
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
Carbonic anhydrase 1	0	14	0	26
Carbonic anhydrase 2	0	14	1	28
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	6	0	9
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Carbonic anhydrase-like protein, putative	0	0	0	9
Carbonic anhydrase 4	0	5	0	8
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	2	2
ras protein, partial	0	0	2	2
interleukin 8	7	0	0	7
Rac1 protein	0	0	2	2
IDH1	26	0	0	26
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	2	2
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Epidermal growth factor receptor	0	8	0	8
Fatty acid-binding protein, liver	0	4	0	4
Myeloperoxidase	0	5	0	5
Prostaglandin G/H synthase 1	0	5	0	5
Seed linoleate 13S-lipoxygenase-1	0	2	0	2
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	7	0	8
Adenosine receptor A2a	0	6	1	14
Substance-P receptor	0	3	0	3
Prostaglandin G/H synthase 2	0	6	1	8
Urotensin-2 receptor	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Nuclear receptor ROR-gamma	13	2	2	17
Ras-related protein Rab-2A	0	0	2	2
Prostaglandin G/H synthase 2	0	3	0	3
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	4	0	4
Solute carrier family 22 member 6	0	4	0	4
glp-1 receptor, partial	23	0	0	23
cystic fibrosis transmembrane conductance regulator	0	1	0	1
short transient receptor potential channel 6 isoform 1	0	0	2	2
Muscarinic acetylcholine receptor M1	0	1	0	2
Muscarinic acetylcholine receptor M4	0	4	0	4
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	3	2	6
Gamma-aminobutyric acid type B receptor subunit 2	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	2	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	10	0	0	10
Rap guanine nucleotide exchange factor 3	5	0	0	5
Zinc finger protein mex-5	0	0	1	1
Genome polyprotein	0	1	0	1
Replicase polyprotein 1ab	0	12	7	19
Hexokinase-2	0	1	0	1
Spike glycoprotein	0	3	7	10
Replicase polyprotein 1ab	0	4	7	11
Transmembrane protease serine 2	0	3	7	10
Procathepsin L	0	4	7	11
Replicase polyprotein 1a	0	3	7	10
Replicase polyprotein 1ab	0	3	7	10
Replicase polyprotein 1ab	0	5	7	12
Angiotensin-converting enzyme 2	0	3	7	10
Telomerase reverse transcriptase	0	1	0	1
Acetylcholinesterase	0	11	0	12
Lysine-specific histone demethylase 1A	0	3	0	4
Neuraminidase	0	1	0	1
Neuraminidase	0	1	0	1
Cholinesterase	0	8	0	8
Tyrosine-protein phosphatase non-receptor type 1	0	2	0	4
Acetylcholinesterase	0	13	2	16
Aldo-keto reductase family 1 member C3	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Cholinesterase	0	9	0	10
Cytochrome P450 1B1	0	8	0	8
Gamma-aminobutyric acid receptor subunit pi	0	12	0	12
Gamma-aminobutyric acid receptor subunit delta	0	12	0	12
Gamma-aminobutyric acid receptor subunit alpha-1	0	13	4	17
Gamma-aminobutyric acid receptor subunit beta-1	0	12	1	13
Gamma-aminobutyric acid receptor subunit gamma-2	0	13	3	16
Gamma-aminobutyric acid receptor subunit beta-3	0	13	3	16
Gamma-aminobutyric acid receptor subunit alpha-5	0	13	4	17
Gamma-aminobutyric acid receptor subunit alpha-3	0	13	3	16
Gamma-aminobutyric acid receptor subunit alpha-2	0	13	2	15
Gamma-aminobutyric acid receptor subunit beta-2	0	12	2	14
Gamma-aminobutyric acid receptor subunit alpha-4	0	12	1	13
Gamma-aminobutyric acid receptor subunit epsilon	0	12	0	12
Gamma-aminobutyric acid receptor subunit alpha-6	0	12	1	13
Gamma-aminobutyric acid receptor subunit gamma-1	0	12	0	12
Gamma-aminobutyric acid receptor subunit gamma-3	0	12	0	12
Gamma-aminobutyric acid receptor subunit theta	0	12	0	12
Kappa-type opioid receptor	0	14	1	16
Kappa-type opioid receptor	0	30	9	44
Acetylcholine receptor subunit alpha	0	5	3	8
Acetylcholine receptor subunit gamma	0	5	3	8
Integrin alpha-5	0	1	0	1
Acetylcholine receptor subunit beta	0	5	3	8
UDP-glucuronosyltransferase 2B7	0	3	0	7
Neuronal acetylcholine receptor subunit beta-2	0	8	2	12
UDP-glucuronosyltransferase 1-6	0	2	0	3
Cytochrome P450 2B6	0	3	1	6
UDP-glucuronosyltransferase 1A1	0	5	0	6
Neuronal acetylcholine receptor subunit beta-4	0	7	2	11
Neuronal acetylcholine receptor subunit alpha-3	0	7	2	9
Cytochrome P450 2C19	0	15	1	18
UDP-glucuronosyltransferase 2B10	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	5	2	7
Neuronal acetylcholine receptor subunit alpha-4	0	8	2	12
Acetylcholine receptor subunit delta	0	5	3	8
Beta-2 adrenergic receptor	0	8	0	9
Angiotensin-converting enzyme	0	1	0	1
Beta-1 adrenergic receptor	0	7	1	9
Beta-3 adrenergic receptor	0	6	0	6
Alpha-2A adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	1	0	1
Lysosomal alpha-glucosidase	0	2	0	2
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, glycogen phosphorylase, liver form	0	0	2	2
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, Chitinase	0	1	0	1
Potassium channel subfamily K member 2	0	6	9	15
Glycogen phosphorylase, muscle form	0	2	0	2
Renin	0	1	0	1
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Adenosine receptor A3	0	14	1	15
Amine oxidase [flavin-containing] A	0	8	0	9
Amine oxidase [flavin-containing] B	0	11	1	13
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	4	3	8
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	3	1	5
Adenosine receptor A1	0	6	1	9
Vasopressin V2 receptor	0	0	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	1	0	2
Chitotriosidase-1	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	2	2	4
Endochitinase B1	0	1	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	9	1	11
Guanine deaminase	0	2	0	3
L-lactate dehydrogenase A chain	0	2	0	2
Cytochrome P450 1A1	0	3	0	3
Cytochrome P450 2C11	0	2	0	2
Cytochrome P450 2D6	0	37	2	41
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Cytochrome P450 3A5	0	3	0	3
Cytochrome P450 3A7	0	2	0	2
Caspase-1	0	0	1	1
Mu-type opioid receptor	0	38	10	52
Peroxisome proliferator-activated receptor gamma	0	0	5	5
Delta-type opioid receptor	0	24	7	35
N-acylethanolamine-hydrolyzing acid amidase	0	1	0	1
Heat sensitive channel TRPV3	0	1	1	2
Sigma intracellular receptor 2	0	3	0	3
Transient receptor potential cation channel subfamily A member 1	0	1	2	3
Transient receptor potential cation channel subfamily M member 8	0	1	0	1
Transient receptor potential cation channel subfamily V member 4	0	2	1	3
G-protein coupled receptor 55	0	1	2	3
Diacylglycerol lipase-alpha	0	1	0	1
Chain A, Beta-lactamase	24	0	0	24
Vpr	3	0	0	3
Major prion protein	0	0	5	5
Sodium channel protein type 1 subunit alpha	0	5	0	5
Sodium channel protein type 2 subunit alpha	0	9	0	9
Sodium channel protein type 3 subunit alpha	0	4	0	4
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	2	0	2
Chain A, serum paraoxonase	0	1	0	1
Carbonic anhydrase 12	0	6	0	13
Carbonic anhydrase 3	0	5	0	11
Neutrophil cytosol factor 1	0	1	0	1
Carbonic anhydrase 4	0	5	0	12
Carbonic anhydrase 6	0	5	0	12
Carbonic anhydrase 5A, mitochondrial	0	5	1	13
Carbonic anhydrase 7	0	5	0	12
Carbonic anhydrase 9	0	7	0	15
Carbonic anhydrase 13	0	3	0	6
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
Carbonic anhydrase 14	0	4	0	11
Carbonic anhydrase 5B, mitochondrial	0	5	0	12
Chain A, Carbonic anhydrase II	0	1	0	1
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	3	0	3
caspase 7, apoptosis-related cysteine protease	13	0	0	13
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	3	0	3
caspase-3	13	0	0	13
thyrotropin-releasing hormone receptor	4	0	0	4
Caspase-7	9	0	0	9
interferon gamma precursor	0	0	0	3
prostaglandin E2 receptor EP2 subtype	0	0	0	2
caspase-3	9	0	0	9
Prostaglandin E synthase	0	1	0	1
3-phosphoinositide-dependent protein kinase 1	0	1	0	1
Cytochrome c oxidase subunit 1	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Quinolone resistance protein NorA	0	3	0	4
Beta-3 adrenergic receptor	0	10	1	11
Calpain-2 catalytic subunit	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Cruzipain	0	1	0	1
Sodium/hydrogen exchanger 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	4	0	4
Delta-type opioid receptor	0	18	3	26
Delta-type opioid receptor	0	15	4	21
Mu-type opioid receptor	0	19	4	26
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase	0	3	0	9
Carbonic anhydrase	0	3	0	10
Carbonic anhydrase	0	2	0	2
Beta-carbonic anhydrase 1	0	3	0	3
Carbonic anhydrase 2	0	3	0	3
Prostaglandin G/H synthase 2	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Carbonic anhydrase, alpha family	0	3	0	3
Carbonic anhydrase	0	3	0	10
Carbonic anhydrase	0	2	0	9
Carbonic anhydrase	0	3	0	10
Carbonic anhydrase	0	3	0	3
Sigma intracellular receptor 2	0	10	0	10
Delta carbonic anhydrase	0	3	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase	0	3	0	10
Prostaglandin G/H synthase 1	0	1	0	1
Cyclooxygenase-2	0	1	0	1
Rap guanine nucleotide exchange factor 4	3	0	0	3
Carbonic anhydrase 15	0	5	0	11
P2Y purinoceptor 12	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	6	0	7
Gamma-aminobutyric acid receptor subunit beta-1	0	6	0	7
Gamma-aminobutyric acid receptor subunit alpha-2	0	6	0	7
Gamma-aminobutyric acid receptor subunit alpha-3	0	6	0	7
Gamma-aminobutyric acid receptor subunit alpha-4	0	6	0	7
Gamma-aminobutyric acid receptor subunit gamma-2	0	6	0	7
Cholecystokinin receptor type A	0	4	0	4
Gastrin/cholecystokinin type B receptor	0	4	0	4
Proteasome subunit beta type-11	0	0	0	1
NADPH oxidase 1	0	4	0	4
Snq2p	0	0	0	9
Adenylate cyclase type 1	0	4	0	4
histone deacetylase 9 isoform 3	3	0	0	3
ras-related protein Rab-9A	18	0	0	18
Proteasome subunit alpha type-7	0	0	0	1
Transient receptor potential cation channel subfamily V member 1	0	2	0	2
Albumin	0	2	9	16
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	3	0	3
Receptor tyrosine-protein kinase erbB-2	0	4	0	4
Major prion protein	0	0	1	1
Tyrosine-protein kinase Fyn	0	7	0	7
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	4	2	6
Polyunsaturated fatty acid lipoxygenase ALOX15	0	5	0	5
Sphingomyelin phosphodiesterase	0	2	0	2
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	12	0	12
Adenylate cyclase type 3	0	4	0	4
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	4	0	4
Adenylate cyclase type 4	0	4	0	4
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
Trypanothione reductase	0	12	0	12
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	6	0	6
Pleiotropic ABC efflux transporter of multiple drugs	0	9	0	18
Adenylate cyclase type 8	0	4	0	4
Proteasome subunit beta type-10	0	0	0	1
Melanocortin receptor 3	0	2	0	2
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
Gastrin/cholecystokinin type B receptor	0	3	0	3
Proteasome subunit alpha type-6	0	0	4	5
Calmodulin	0	1	4	5
Aldehyde oxidase 1	0	1	0	1
Adenylate cyclase type 6	0	4	0	4
Adenylate cyclase type 5	0	4	0	4
Aldehyde oxidase	0	3	0	5
Adenylyl cyclase 7	0	4	0	4
Proteasome subunit alpha-type 8	0	0	0	1
Proteasome subunit beta type-7	0	0	0	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	5	4	10
Neuronal acetylcholine receptor subunit alpha-2	0	4	3	8
Neuronal acetylcholine receptor subunit beta-3	0	3	4	8
Neuronal acetylcholine receptor subunit beta-4	0	5	4	10
Neuronal acetylcholine receptor subunit alpha-5	0	3	3	7
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	2	0	3
Neuronal acetylcholine receptor subunit alpha-6	0	3	4	8
Neuronal acetylcholine receptor subunit alpha-9	0	3	3	7
Neuronal acetylcholine receptor subunit alpha-7	0	9	4	14
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	3	3	7
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	2	0	5
DNA gyrase subunit B	0	2	0	5
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
DNA topoisomerase 2-alpha	0	2	0	6
DNA gyrase subunit A	0	1	0	2
Multidrug resistance protein MdtK	0	0	1	1
DNA gyrase subunit B	0	2	0	3
DNA gyrase subunit A	0	2	0	3
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	2	0	2
NPC intracellular cholesterol transporter 1 precursor	14	0	0	14
Sodium-dependent noradrenaline transporter	0	5	0	5
Aldo-keto reductase family 1 member B1	0	3	0	3
Aromatase	0	1	0	1
Sodium-dependent serotonin transporter	0	5	0	5
Sodium-dependent dopamine transporter	0	6	0	6
Transporter	0	20	2	23
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	2	0	2
General amino-acid permease GAP1	0	0	0	1
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
urokinase-type plasminogen activator precursor	6	0	0	6
plasminogen precursor	6	0	0	6
urokinase plasminogen activator surface receptor precursor	6	0	0	6
streptokinase A precursor	0	0	4	4
Solute carrier organic anion transporter family member 1B3	0	6	0	7
Solute carrier organic anion transporter family member 1B1	0	6	0	8
Trypanothione reductase	0	1	0	1
Envelope glycoprotein	0	0	4	4
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	2	0	0	2
Translocator protein	0	2	0	2
Translocator protein	0	5	1	7
Beta-1 adrenergic receptor	0	2	2	5
Alpha-1B adrenergic receptor	0	0	2	2
Membrane primary amine oxidase	0	1	0	1
Solute carrier family 22 member 3	0	10	0	11
Alpha-1A adrenergic receptor	0	3	2	5
Alpha-2B adrenergic receptor	0	1	0	2
Alpha-2C adrenergic receptor	0	1	0	2
Alpha-2A adrenergic receptor	0	1	0	2
Nischarin	0	2	0	2
Nischarin	0	3	0	3
bromodomain adjacent to zinc finger domain 2B	17	0	0	17
transient receptor potential cation channel subfamily V member 1	3	0	0	3
Endothelin receptor type B	0	3	0	3
5-hydroxytryptamine receptor 3A	0	4	0	4
Endothelin receptor type B	0	3	0	3
D(2) dopamine receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
D(2) dopamine receptor	0	7	0	7
5-hydroxytryptamine receptor 2B	0	3	0	3
5-hydroxytryptamine receptor 4	0	2	0	2
Transporter	0	6	0	6
Cholecystokinin receptor type A	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Histamine H4 receptor	0	6	5	11
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Amyloid-beta precursor protein	2	5	0	7
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	1	2
Liver carboxylesterase 1	0	2	0	4
Lysosomal Pro-X carboxypeptidase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	3
Leukotriene B4 receptor 1	0	1	0	2
Leukotriene B4 receptor 2	0	1	0	2
Cytochrome P450 2D1	0	3	0	3
Cytochrome P450 2D26	0	3	0	3
Cytochrome P450 2D3	0	3	0	3
Kappa-type opioid receptor	0	9	3	14
Mu-type opioid receptor	0	9	3	16
Cytochrome P450 2D4	0	3	0	3
Mas-related G-protein coupled receptor member X2	0	0	7	7
GALC protein	11	0	0	11
nonstructural protein 1	11	0	0	11
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
Mineralocorticoid receptor	0	2	2	4
Androgen receptor	0	10	0	10
C-8 sterol isomerase	0	5	0	5
Solute carrier organic anion transporter family member 1A1	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	5	0	5
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	5	0	5
Chain A, N-methyl-D-aspartate Receptor Subunit 1	0	1	0	1
Chain A, N-methyl-D-aspartate Receptor Subunit 1	0	1	0	1
Chain A, N-methyl-D-aspartate Receptor Subunit 1	0	1	0	1
D-alanine--D-alanine ligase	0	1	0	1
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	0	1	0	1
chaperonin GroEL	1	0	0	1
Glycogen phosphorylase, brain form	0	2	0	2
Glycogen phosphorylase, muscle form	0	2	0	2
Histone-lysine N-methyltransferase SETD7	0	2	0	2
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	12	0	0	12
Glucocorticoid receptor	0	8	2	15
Progesterone receptor	0	3	0	4
Glycine receptor subunit alpha-1	0	8	0	8
Androgen receptor	0	7	0	7
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
ORF73	0	0	1	1
Histamine H3 receptor	0	3	0	3
Solute carrier family 22 member 4	0	1	0	1
Amine oxidase [flavin-containing] B	0	5	0	6
Amine oxidase [flavin-containing] B	0	3	0	4
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	2	2
Trace amine-associated receptor 1	0	0	3	3
Gamma-aminobutyric acid	0	2	2	4
Alpha-1-acid glycoprotein 1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	2	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	2	4
Gamma-aminobutyric acid receptor subunit delta	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	2	4
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	2	4
Gamma-aminobutyric acid receptor subunit beta-1	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	2	5
Gamma-aminobutyric acid receptor subunit beta-3	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	2	4
Gamma-aminobutyric acid receptor subunit pi	0	2	2	4
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	2	4
Gamma-aminobutyric acid receptor subunit theta	0	2	2	4
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	2	4
PAX8	0	0	0	1
STAT3, partial	0	1	0	1
tumor necrosis factor	3	0	0	3
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	3	0	6
Sodium/potassium-transporting ATPase subunit alpha-1	0	3	0	3
Sodium/potassium-transporting ATPase subunit beta-1	0	3	0	3
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
ATP-dependent translocase ABCB1	0	9	0	9
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-2	0	2	0	2
ATP-dependent translocase ABCB1	0	9	0	10
Sodium/potassium-transporting ATPase subunit alpha-2	0	3	0	3
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit gamma	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-4	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	3
Solute carrier organic anion transporter family member 4C1	0	0	0	2
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Synaptic vesicular amine transporter	0	7	2	9
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
runt-related transcription factor 1 isoform AML1b	2	0	0	2
core-binding factor subunit beta isoform 2	2	0	0	2
Caspase-7	3	0	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	8	0	8
Voltage-dependent L-type calcium channel subunit alpha-1C	0	6	0	6
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Potassium voltage-gated channel subfamily A member 1	0	2	0	2
Kappa-type opioid receptor	0	9	5	15
Acetylcholinesterase	0	2	0	2
Amine oxidase [flavin-containing] A	0	4	0	5
Amine oxidase [flavin-containing] A	0	3	0	4
Acetylcholinesterase	0	3	0	3
Acetylcholinesterase	0	4	0	4
Acetylcholinesterase	0	2	0	2
Beta-secretase 1	0	1	0	1
Cholinesterase	0	2	0	2
Acetylcholine receptor subunit epsilon	0	1	2	3
Acyl-CoA:cholesterol acyltransferase	0	2	0	2
Carboxylic ester hydrolase	0	2	0	3
Carboxylic ester hydrolase	0	4	0	4
Histamine H3 receptor	0	2	1	4
Nuclear receptor subfamily 1 group I member 2	0	0	4	4
Transient receptor potential cation channel subfamily A member 1	0	0	2	3
Glycine receptor subunit alpha-1	0	0	4	4
N-arachidonyl glycine receptor	0	0	1	1
Lysophosphatidylserine lipase ABHD12	0	1	0	1
Monoglyceride lipase	0	1	0	1
Monoacylglycerol lipase ABHD6	0	1	0	1
N-acetyltransferase Eis	0	3	0	3
chaperonin-containing TCP-1 beta subunit homolog	3	0	0	3
ubiquitin-conjugating enzyme E2 N	0	2	0	2
protein AF-9 isoform a	0	0	0	3
histone-lysine N-methyltransferase 2A isoform 2 precursor	9	0	0	9
Estrogen receptor	0	4	0	4
Alpha-synuclein	5	3	0	8
Opioid receptor, delta 1b	0	2	0	2
Opioid receptor homologue	0	2	0	2
Proenkephalin-B	0	0	1	1
Mu-type opioid receptor	0	2	0	2
Adenylate cyclase	0	1	0	1
Tyrosine-protein kinase Lck	0	2	1	3
Beta-2 adrenergic receptor	0	7	1	8
Thromboxane-A synthase	0	4	0	4
5-hydroxytryptamine receptor 1B	0	6	1	7
Motilin receptor	0	0	1	1
acid sphingomyelinase	1	0	0	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
serine/threonine-protein kinase PLK1	5	0	0	5
Motilin receptor	0	1	1	2
30S ribosomal protein S6	0	2	1	3
30S ribosomal protein S7	0	2	1	3
50S ribosomal protein L15	0	2	1	3
60 kDa chaperonin	0	3	0	3
50S ribosomal protein L10	0	2	1	3
50S ribosomal protein L11	0	2	1	3
50S ribosomal protein L7/L12	0	2	1	3
50S ribosomal protein L19	0	2	1	3
50S ribosomal protein L1	0	2	1	3
50S ribosomal protein L20	0	2	1	3
50S ribosomal protein L27	0	2	1	3
50S ribosomal protein L28	0	2	1	3
50S ribosomal protein L29	0	2	1	3
50S ribosomal protein L31	0	2	1	3
50S ribosomal protein L31 type B	0	2	1	3
50S ribosomal protein L32	0	2	1	3
50S ribosomal protein L33	0	2	1	3
50S ribosomal protein L34	0	2	1	3
50S ribosomal protein L35	0	2	1	3
50S ribosomal protein L36	0	2	1	3
30S ribosomal protein S10	0	2	1	3
30S ribosomal protein S11	0	2	1	3
30S ribosomal protein S12	0	2	1	3
30S ribosomal protein S13	0	2	1	3
30S ribosomal protein S16	0	2	1	3
30S ribosomal protein S18	0	2	1	3
30S ribosomal protein S19	0	2	1	3
30S ribosomal protein S20	0	2	1	3
30S ribosomal protein S2	0	2	1	3
30S ribosomal protein S3	0	2	1	3
30S ribosomal protein S4	0	2	1	3
30S ribosomal protein S5	0	2	1	3
30S ribosomal protein S8	0	2	1	3
30S ribosomal protein S9	0	2	1	3
50S ribosomal protein L13	0	2	1	3
50S ribosomal protein L14	0	2	1	3
50S ribosomal protein L16	0	2	1	3
50S ribosomal protein L23	0	2	1	3
30S ribosomal protein S15	0	2	1	3
50S ribosomal protein L17	0	2	1	3
50S ribosomal protein L21	0	2	1	3
50S ribosomal protein L30	0	2	1	3
50S ribosomal protein L6	0	2	1	3
30S ribosomal protein S14	0	2	1	3
30S ribosomal protein S17	0	2	1	3
30S ribosomal protein S1	0	2	1	3
50S ribosomal protein L18	0	2	1	3
60 kDa heat shock protein, mitochondrial	0	3	0	3
Chitinase B	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
50S ribosomal protein L2	0	2	1	3
50S ribosomal protein L3	0	2	1	3
50S ribosomal protein L24	0	2	1	3
50S ribosomal protein L4	0	2	1	3
50S ribosomal protein L22	0	2	1	3
10 kDa heat shock protein, mitochondrial	0	3	0	3
50S ribosomal protein L5	0	2	1	3
30S ribosomal protein S21	0	2	1	3
50S ribosomal protein L25	0	2	1	3
Thiosulfate sulfurtransferase	0	3	0	3
50S ribosomal protein L36 2	0	2	1	3
60 kDa chaperonin	0	3	0	3
10 kDa chaperonin	0	3	0	3
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	3	0	3
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	3	0	3
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase	0	1	0	1
muscleblind-like protein 1 isoform 1	11	0	0	11
Voltage-dependent T-type calcium channel subunit alpha-1G	0	0	2	2
Voltage-dependent T-type calcium channel subunit alpha-1H	0	0	1	1
Voltage-dependent L-type calcium channel subunit beta-1	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1I	0	0	1	1
Prostaglandin D2 receptor 2	0	1	0	1
Cytochrome P450 2C8	0	6	0	6
Dipeptidyl peptidase 4	0	1	0	1
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Cocaine esterase	0	3	0	4
Arylacetamide deacetylase	0	0	0	1
Arylacetamide deacetylase	0	0	0	1
Arylacetamide deacetylase	0	0	0	1
Cytochrome P450 1A2	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	2	3
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	3	0	3
Sodium- and chloride-dependent GABA transporter 3	0	3	0	3
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	3
Sterol O-acyltransferase 1	0	0	1	1
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Succinate-semialdehyde dehydrogenase, mitochondrial	0	1	0	1
Asialoglycoprotein receptor 1	0	1	1	2
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	3	0	0	3
Metabotropic glutamate receptor 8	0	2	0	2
Glutathione reductase, mitochondrial	0	4	0	4
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	2	2
ATP-citrate synthase	0	1	0	1
Metabotropic glutamate receptor 1	0	2	1	3
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	1	2	3
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Metabotropic glutamate receptor 5	0	1	2	4
Metabotropic glutamate receptor 8	0	0	1	1
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Glutamate carboxypeptidase 2	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	2	0	2
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	2	0	2
Amino acid transporter	0	2	0	2
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	8	0	9
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
POU domain, class 2, transcription factor 1	0	0	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	2	0	4
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	2	2
Integrin beta-1	0	1	0	1
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
5-hydroxytryptamine receptor 2A	0	2	1	3
AP-2 complex subunit sigma	0	1	0	1
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	3	0	3
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	3	0	3
Protease	0	8	2	14
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Plasma kallikrein	0	0	0	6
Macrophage migration inhibitory factor	0	2	0	2
Histamine H3 receptor	0	2	0	2
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	2	0	2
Equilibrative nucleoside transporter 4	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 13	0	2	0	8
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Histidine-binding periplasmic protein	0	0	1	1
ClpP	3	0	0	3
Solute carrier family 22 member 8	0	2	0	3
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
Chain A, PROTEIN (PROTEASE)	0	1	0	1
Chain B, PROTEIN (PROTEASE)	0	1	0	1
Chain A, PROTEIN (PROTEASE)	0	1	0	1
Chain B, PROTEIN (PROTEASE)	0	1	0	1
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, HIV-II PROTEASE	0	1	0	1
Chain B, HIV-II PROTEASE	0	1	0	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, POL polyprotein	0	2	0	2
Chain B, POL polyprotein	0	2	0	2
Chain A, POL polyprotein	0	2	0	2
Chain B, POL polyprotein	0	2	0	2
Chain A, HIV-1 protease	0	1	0	1
Chain B, HIV-1 protease	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Gag-Pol polyprotein	0	3	0	3
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	2	0	2
Gag polyprotein	0	1	0	1
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	4	0	4
Gag-Pol polyprotein	0	2	0	2
Thromboxane-A synthase	0	0	0	2
Protease	0	4	2	6
Protease	0	1	0	1
Peptide deformylase 1A, chloroplastic/mitochondrial	0	1	0	1
Peptide deformylase	0	1	0	1
Chain A, ADENOSINE DEAMINASE	0	1	0	1
Chain A, ADENOSINE DEAMINASE	0	1	0	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
Adenosylhomocysteinase	0	1	0	2
Adenosine deaminase	0	1	0	1
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
Sodium/myo-inositol cotransporter 2	0	1	0	1
Chain A, BETA-SPECTRIN	0	0	1	1
Chain A, Phospholipase C Delta-1	0	0	1	1
Chain A, Inositol 1,4,5-trisphosphate receptor type 1	0	0	1	1
Inositol-trisphosphate 3-kinase A	0	1	0	1
Inositol 1,4,5-trisphosphate receptor type 1	0	0	2	2
Inositol 1,4,5-trisphosphate receptor type 2	0	1	0	1
Inositol 1,4,5-trisphosphate receptor type 3	0	1	1	2
Inositol polyphosphate-5-phosphatase A	0	1	0	1
Inositol 1,4,5-trisphosphate receptor type 1	0	1	1	2
N-glycosylase/DNA lyase	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	2	0	2
phosphoethanolamine/phosphocholine phosphatase isoform 1	0	1	0	1
Microtubule-associated protein tau	0	1	0	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	1	0	0	1
Fatty acid synthase	0	3	0	3
WD repeat-containing protein 5	0	1	0	1
Histone-lysine N-methyltransferase 2A	0	1	0	1
Cytosolic endo-beta-N-acetylglucosaminidase	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	3	0	3
Gonadotropin-releasing hormone receptor	0	1	0	1
Gonadotropin-releasing hormone receptor	0	2	0	2
Synaptic vesicle glycoprotein 2A	0	2	0	2
WRN	2	0	0	2
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
pyruvate kinase	3	0	0	3
hexokinase-4 isoform 1	2	0	0	2
glucokinase regulatory protein	2	0	0	2
DNA polymerase eta isoform 1	4	0	0	4
Polyphenol oxidase 2	0	1	0	4
Tyrosinase	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
SLC16A10 protein	0	0	0	4
Monocarboxylate transporter 10	0	0	0	4
phosphoglycerate kinase	2	0	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
5-hydroxytryptamine receptor 1E	0	2	0	2
Sodium-dependent dopamine transporter	0	1	0	1
Cysteinyl leukotriene receptor 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Aromatase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Dihydrofolate reductase	0	4	0	4
Dipeptidyl peptidase 4	0	1	1	2
Aldehyde oxidase 1	0	2	0	2
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	1	0	2
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Lactoperoxidase	0	1	0	1
5-hydroxytryptamine receptor 3B	0	2	0	2
Stromelysin-1	0	2	1	3
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Protein-arginine deiminase type-4	0	3	0	3
Chain A, Probable serine/threonine-protein kinase pknB	0	1	0	1
DNA polymerase III, partial	2	0	0	2
nonstructural protein 1	0	1	0	1
LANA	0	0	0	1
phospholipase A2, group III	0	1	0	1
histone-lysine N-methyltransferase NSD2 isoform 1	0	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
rac GTPase-activating protein 1 isoform a	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	3
pyruvate kinase PKM isoform b	3	0	0	3
Glycoprotein hormones alpha chain	2	0	0	2
Proto-oncogene tyrosine-protein kinase ROS	0	1	0	1
Ornithine decarboxylase	3	0	0	4
DNA topoisomerase 2	0	0	0	1
Multidrug resistance-associated protein 1	0	3	1	5
DNA topoisomerase 2-beta	0	0	0	1
Tyrosine-protein kinase BTK	0	1	0	1
NEDD8-activating enzyme E1 regulatory subunit	0	0	1	1
Casein kinase II subunit alpha 3	0	1	0	1
NEDD8-activating enzyme E1 catalytic subunit	0	0	1	1
Single-stranded DNA cytosine deaminase	1	0	0	1
P2Y purinoceptor 12	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Histidine decarboxylase	0	0	3	3
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	2
Nociceptin receptor	0	1	0	1
Neurotensin receptor type 1	0	0	1	1
Neurotensin receptor type 2	0	1	1	3
Myelin basic protein	0	0	1	1
Neurotensin receptor type 1	0	1	1	2
Neurotensin receptor type 1	0	2	2	5
Neurotensin receptor type 2	0	2	1	3
Sortilin	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	2	2
Neuronal acetylcholine receptor subunit alpha-7	0	3	0	3
Acetylcholine-binding protein	0	1	1	2
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	3	2	5
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
eyes absent homolog 2 isoform a	1	0	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Phospholipase A2, membrane associated	0	0	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Platelet-activating factor receptor	0	0	0	1
C-C chemokine receptor type 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
STE24	0	0	0	1
CAAX prenyl protease	0	0	0	1
Trypsin	0	0	0	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Interleukin-6 receptor subunit alpha	0	1	0	1
Thyrotropin-releasing hormone receptor	0	1	0	1
Glycine receptor subunit alpha-4	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	1	0	1
DNA repair protein RAD52 homolog	0	1	0	1
MBT domain-containing protein 1	0	1	0	1
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
Oxytocin receptor	0	0	1	1
Phenylethanolamine N-methyltransferase	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	2	0	2
Beta-adrenergic receptor kinase 1	0	1	1	2
Substance-P receptor	0	3	1	4
Rhodopsin kinase GRK1	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
P2X purinoceptor 4	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
Beta-adrenergic receptor kinase 1	0	0	0	1
bcl-2-related protein A1	0	1	0	1
Aldehyde oxidase 1	0	1	0	1
Retinal dehydrogenase 1	0	1	0	1
Aldehyde oxidase 1	0	1	0	1
Chain A, TRYPSIN	0	1	0	1
Chain A, TRYPSIN	0	1	0	1
Chain A, TRYPSIN	0	1	0	1
Chain A, TRYPSIN	0	1	0	1
Chain A, TRYPSIN	0	1	0	1
Chain A, TRYPSIN	0	1	0	1
Flavodoxin	0	0	0	1
Membrane primary amine oxidase	0	0	0	1
Cationic trypsin	0	1	0	1
Membrane primary amine oxidase	0	0	0	1
Lysyl oxidase homolog 2	0	1	0	1
Aldo-keto reductase family 1 member B1	0	3	0	3
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	2	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Phospholipase A-2-activating protein	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Acetylcholinesterase	0	1	0	1
XBP1	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	3	0	0	3
DNA damage-inducible transcript 3 protein	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase 1	0	2	0	2
WD repeat-containing protein 48	0	2	0	2
Muscarinic acetylcholine receptor DM1	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
luciferase	0	0	0	1
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 7	0	1	0	2
Canalicular multispecific organic anion transporter 1	0	1	0	1
Pannexin-1	0	1	0	1
Solute carrier family 22 member 12	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	2	0	2
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
Pannexin-1	0	1	0	1
Solute carrier family 22 member 11	0	2	0	2
Solute carrier family 22 member 7	0	2	0	2
Chloroquine resistance transporter	0	2	0	2
Endothelin-1 receptor	0	1	1	2
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	2	0	2
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Pyridoxal kinase	0	0	0	1
Dipeptidyl peptidase 4	0	0	1	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
caspase-1 isoform alpha precursor	2	0	0	2
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
DNA topoisomerase 1	0	2	0	2
Chromaffin granule amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	3	1	4
Synaptic vesicular amine transporter	0	2	0	2
Ribonuclease HI	0	1	0	1
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain H, Immunoglobulin Igg1 Heavy chain	0	0	1	1
Chain L, Immunoglobulin Igg1 Lambda Light Chain	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain C, DODECIN	0	0	1	1
Chain E, DODECIN	0	0	1	1
NPYLR7B	0	0	1	1
Riboflavin-binding protein	0	1	1	2
Pteridine reductase 1	0	2	0	2
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Gag-Pol polyprotein	0	1	0	1
Plasmepsin V	0	1	0	1
Estrogen receptor beta	0	1	0	2
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Estrogen receptor	0	1	0	2
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 3	0	1	0	1
Adenylate cyclase type 9	0	1	0	1
D(1) dopamine receptor	0	1	0	1
Adenylate cyclase type 8	0	1	0	1
Adenylate cyclase type 7	0	1	0	1
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
Cytochrome P450 2B1	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Amine oxidase [flavin-containing] A	0	0	0	1
Amine oxidase [flavin-containing] B	0	0	0	1
Pyruvate kinase PKM	0	0	1	1
Transcriptional activator protein LuxR	0	1	0	1
alternatively spliced Trp4	0	0	1	1
5-hydroxytryptamine receptor 1E	0	1	0	1
sphingosine 1-phosphate receptor 3	0	1	0	1
Beta-casein	0	1	0	1
D(3) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
D(4) dopamine receptor	0	1	0	1
D(1B) dopamine receptor	0	1	0	1
Tissue factor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Neuromedin-K receptor	0	1	1	2
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Carbonic anhydrase	0	2	0	2
D(2) dopamine receptor	0	1	0	1
Cathepsin D	0	1	0	1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Transthyretin	0	1	0	3
Thyroid hormone receptor alpha	0	2	3	5
Thyroid hormone receptor beta	0	2	3	5
Proliferating cell nuclear antigen	0	2	0	2
Retinoic acid receptor RXR-alpha	0	2	4	6
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Solute carrier organic anion transporter family member 1A3	0	0	0	2
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	0	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Cytochrome P450 2E1	0	1	0	1
Cytochrome P450 4B1	0	1	0	1
Cytochrome P450 2A7	0	1	0	1
Cytochrome P450 2F1	0	1	0	1
Cytochrome P450 2C18	0	1	0	1
Cytochrome P450 4F2	0	1	0	1
Cytochrome P450 4F8	0	1	0	1
Cytochrome P450 4A11	0	1	0	1
Cytochrome P450 4F3	0	1	0	1
Cytochrome P450 4A22	0	1	0	1
Vitamin D 25-hydroxylase	0	1	0	1
Cytochrome P450 2U1	0	1	0	1
Cytochrome P450 2W1	0	1	0	1
Cytochrome P450 2S1	0	1	0	1
Cytochrome P450 3A43	0	1	0	1
REST corepressor 3	0	1	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	2	2	7
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Nuclear receptor ROR-beta	0	1	0	1
Genome polyprotein	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	1	0	2
Lysozyme C-1	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Beta-glucuronidase	0	1	0	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Protein kinase C eta type	0	1	0	1
Calcium-dependent protein kinase 4	0	1	0	1
Emopamil-binding protein-like	0	1	0	1
Protein kinase C theta type	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Vif	0	1	0	1
Tat	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	3
Strictosidine synthase	0	0	0	1
Cathepsin K	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Trp operon repressor	0	0	1	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Chain A, Arginase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Glycoprotein	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
Alpha-2A adrenergic receptor	0	1	0	1
M-phase inducer phosphatase 1	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Aspartate aminotransferase, cytoplasmic	0	1	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (1,275)

Protein Targets (1,712)

Tourette Syndrome

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (1,275)

Drugs Studied (361)

Protein Targets (1,712)