Compounds > triazoles
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triazoles and Seizures

triazoles has been researched along with Seizures in 115 studies

Research

Studies (115)

TimeframeStudies, this research(%)All Research%
pre-19908 (6.96)18.7374
1990's12 (10.43)18.2507
2000's26 (22.61)29.6817
2010's55 (47.83)24.3611
2020's14 (12.17)2.80

Authors

AuthorsStudies
Liu, D; Wang, Y1
Chen, L; Hou, Z; Huang, L; Li, X; Lian, C; Meng, Q; Wang, Y; Wu, J; Yu, H; Zhang, C1
Imai, K; Inoue, Y; Kagawa, Y; Takahashi, Y; Usui, N; Yamamoto, Y1
Abou-Krisha, MM; Alhamzani, AG; Jeon, BH; Prashanth, MK; Raghu, MS; Yogesh Kumar, K; Yousef, TA1
Abou Tayoun, A; Goldberg, EM; Zaman, T1
Bozarth, XL; Oesch, G1
Gom, RC; Phillips, TJ; Teskey, GC; Wolff, MD1
Jain, J; Singh, UK; Verma, KK2
Bojar, H; Florek-Łuszczki, M; Lepiech, J; Plech, T; Walczak, A; Wróblewska-Łuczka, P; Zagaja, M; Łuszczki, JJ1
Caraballo, RH; Espeche, A; Fasulo, L; Galichio, S; Pociecha, J; Reyes, G; Semprino, M1
Drabik, M; Florek-Łuszczki, M; Głuszak, M; Jankiewicz, M; Kozińska, J; Plech, T; Plewa, Z; Wróblewska-Łuczka, P; Łuszczki, JJ1
Archana, A1
Chou, P; Hsueh, SW; Huang, CS; Kuo, CC; Lai, YC; Lin, TH; Lin, YC; Wang, RW; Yang, YC1
Andres-Mach, M; Cielecka-Piontek, J; Flieger, J; Makuch-Kocka, A; Pizoń, M; Plech, T; Śmiech, A; Zagaja, M1
Dawman, L; Panda, P; Panda, PK; Sharawat, IK1
Anderson, LL; George, AL; Hawkins, NA; Kearney, JA; Thompson, CH1
Gryboś, A; Głuch-Lutwin, M; Jóźwiak, K; Kaproń, B; Karcz, T; Mordyl, B; Nowak, G; Pająk, K; Paneth, A; Plech, T; Siwek, A; Tomczykowski, A; Wujec, M; Łuszczki, J1
Auvin, S; Brandt, C; McMurray, R; Nikanorova, M1
Ahangar, N; Dehestani, L; Emami, S; Hashemi, SM; Honarchian Masihi, P; Irannejad, H; Shakiba, A1
Mahendran, G; Vijayan, R1
Bannon, DI; Jackovitz, AM; Johnson, MS; Koistinen, KA; Lent, EM; Quinn, MJ1
Takahashi, Y; Takayama, R; Tsukamoto, K1
Dalkara, S; Kaynak, FB; Sari, S1
Cielecka-Piontek, J; Ciesla, LM; Gryboś, A; Kaproń, B; Karcz, T; Langner, E; Makuch-Kocka, A; Marciniak, S; Nowak, G; Paczkowska, M; Plech, T; Płazińska, A; Siwek, A; Szalast, K; Walczak, K; Łuszczki, JJ1
Jain, A; Piplani, P1
Asadi, M; Dehpour, AR; Ghasemi, JB; Larijani, B; Mahdavi, M; Mohammadi-Khanaposhtani, M; Rahimi, N; Ranjbar, PR; Shafaroodi, H; Shafie, A1
Deng, XQ; Quan, ZS; Song, MX; Wang, SB1
Cao, X; Deng, XQ; Quan, ZS; Shu, B; Wang, SB1
Cao, X; Liu, DC; Quan, ZS; Shu, B; Wang, SB; Zheng, Y1
Deng, XQ; Quan, ZS; Song, MX; Zheng, Y1
Ahmadi, F; Banafshe, HR; Mahmoodi, B; Mashayekh, S; Motaharian, D; Navidpour, L; Rahmanipour, N; Shafaroodi, H; Shafiee, A; Shahhosseini, S1
Akkaya, E; Doğan, IS; Kahveci, B; Menteşe, E; Ozel, A; Yılmaz, F1
Anderson, LL; Bush, WS; Frankel, WN; George, AL; Hawkins, NA; Kearney, JA; Nath, RD; Petersohn, AA; Rajamani, S; Thompson, CH; Vanoye, CG1
Coppola, G; Delli Pizzi, A; Loiacono, G; Rossi, A; Tartaro, A; Verrotti, A1
Kaproń, B; Kołaczkowski, M; Luszczki, JJ; Nowak, G; Paneth, A; Plech, T; Siwek, A; Wujec, M; Zołnierek, M1
Kaproń, B; Kołaczkowski, M; Luszczki, JJ; Nowak, G; Paneth, A; Plech, T; Siwek, A; Żołnierek, M1
Guan, LP; Quan, ZS1
Dhanda, A; Kamboj, VK; Ranjan, S; Verma, PK1
Guan, LP; Jin, P; Li, FN; Quan, ZS; Wang, SB; Zhang, HJ1
Allis, CD; Darnell, RB; Herre, M; Korb, E; Zucker-Scharff, I1
Abdelrazek, FM; Ayyad, RR; El-Farargy, AF; Nassar, EM1
Aydın, A; Aydınlı, N; Bektaş, G; Çalışkan, M; Özmen, M; Pembegül Yıldız, E; Tatlı, B1
Becerra, JL; Burcet, J; Cano, A; Falip, M; Fernández, S; Fossas, P; Jaraba, S; Miravet, E; Miró, J; Molins, A; Pico, G; Raspall, M; Santamarina, E; Toledo, M1
Hagel, D; Herbet, M; Izdebska, M; Jagiello-Wójtowicz, E; Kędzierska, E; Kosiek, S; Kuśmierz, E; Orzelska-Górka, J; Paneth, A; Piątkowska-Chmiel, I; Plech, T; Wujec, M1
Cormack, LK; Feinberg, LM; Schallert, K; Schallert, T; Spinetta, MJ; Stroud, C; Woodlee, MT1
Alves, AF; Anjos, J; de Hoog, GS; Estevão, H; Faria, E; Gonçalves, T; Hipolito, E; Morais, PV1
Fathollahi, Y; Jahanshahi, A; Javan, M; Mirnajafi-Zadeh, J; Mohammad-Zadeh, M; Motamedi, F; Noorbakhsh, SM1
Bast, T; Boor, R; Ernst, JP; Haberlandt, E; Kluger, G; Kurlemann, G; Makowski, C; Runge, U; Schneider, F1
Guan, LP; Jiang, Z; Piao, HR; Quan, ZS; Zhao, DH1
Bhavna, B; Kumar, K; Narayan, SK; Roopeshkumar, VR; Swaminathan, RP1
Achermann, G; Ballard, T; Buettelmann, B; Fischer, H; Gasser, R; Hernandez, MC; Knoflach, F; Knust, H; Koblet, A; Stadler, H; Thomas, AW; Trube, G; Waldmeier, P1
Agostinho, PM; Cognato, GP; Cunha, RA; Hockemeyer, J; Müller, CE; Souza, DO1
Critchley, DJ; Fuseau, E; Marchand, M1
Deng, XQ; Guan, LP; Quan, YC; Quan, ZS; Sui, X1
Wisniewski, CS1
Bergin, AM; Bourgeois, BF; Duffy, FH; Eksioglu, YZ; Gooty, VD; Kothare, SV; Libenson, M; Loddenkemper, T; Poduri, A; Rotenberg, A; Takeoka, M; Vendrame, M1
Bibbiani, F; Biton, V; Krauss, G; Mann, A; Narurkar, M; Perdomo, C; Vasquez-Santana, B1
Deng, XQ; Li, FN; Quan, ZS; Song, MX; Wei, CX1
Budagumpi, S; Didagi, S; Kulkarni, NV; Kurdekar, GS; Revankar, VK1
Boor, R; Brandt, C; Jürgens, U; Korn-Merker, E; May, TW; Rambeck, B1
Deng, XQ; Quan, LN; Quan, ZS; Song, MX; Wei, CX1
Bortolatto, CF; Jesse, CR; Nogueira, CW; Wilhelm, EA1
Arzimanoglou, A; Brown, LW; Flamini, R; Harrison, M; Kerr, M; Kluger, G; Kothare, S; Narurkar, M; Philip, S; Resnick, T1
Li, W; Zhang, JJ1
Han, RB; Peng, B; Piao, FY; Zhang, W; Zhang, WB1
Chen, X; Kang, H; Li, X; Liu, X; Liu, Z; Shu, K; Zhu, S1
Deng, XQ; Dong, ZQ; Quan, ZS; Shu, B; Song, MX; Wang, SB1
Goel, RS; Gupta, A; Jain, A; Kataria, R; Singh, S; Sinha, VD1
Luszczki, JJ; Plech, T; Wujec, M1
Fiehler, J; Gerloff, C; Kruetzelmann, A; Rosenkranz, M; Sobottka, I; Tolosa, E1
Anna Rita, M; Coppola, G; Curatolo, P; Isone, C; Kluger, G; Mueller, A; Parisi, P; Santoro, E; Verrotti, A; Zamponi, N1
Ko, TS; Lee, EH; Yum, MS1
Deng, XQ; Quan, ZS; Shu, B; Wang, SB; Zheng, Y1
Bian, M; Deng, XQ; Quan, ZS; Wang, SB; Zheng, Y1
Flieger, J; Luszczki, JJ; Pizoń, M; Plech, T; Wujec, M1
Brackenborough, KT; Duffy, C; Hagan, RM; Jones, SA; Morgan, PF; Pratt, GD; Sargent, RS; Southam, E; Stratton, SC1
Akbarzadeh, T; Khoshnoud, MJ; Shafaghi, B; Shafiee, A; Tabatabai, SA1
SICHENEDER, T1
AINSWORTH, C; EASTON, NR; GIBSON, WR; LIVEZEY, M; MORRISON, DE1
Burgess, N; Nigro, O; Shakib, S; Worthley, DL1
Borowicz, KK; Czuczwar, SJ; Sawiniec, A1
Etherington, LA; Frenguelli, BG1
Reddy, DS1
Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N3
Fathollahi, Y; Mirnajafi-Zadeh, J; Namvar, S; Rezvani, ME; Zeraati, M1
AnandaRajagopal, K; Murugesan, S; Rajasekaran, A1
Deeks, ED; Scott, LJ1
Fathollahi, Y; Hosseinmardi, N; Mirnajafi-Zadeh, J; Shahabi, P1
Chai, KY; Chen, J; Lee, JS; Quan, ZS; Song, MS; Sun, XY1
Franklin, MR; Kupferberg, HJ; Schmutz, M; Stables, JP; White, HS; Wolf, HH1
Caliş, U; Demirdamar, R; Erol, DD; Ertan, M; Yuluğ, N1
Ekinci, AC; Ergenç, N; Ulusoy, N1
Bazan, NG; Marcheselli, VL1
Dalton, CR; Dudley, MW; Kane, JM; Kehne, JH; Ketteler, HJ; McCloskey, TC; Miller, FP; Ogden, AM; Senyah, Y; Staeger, MA1
Modica, M; Russo, F; Santagati, A; Santagati, M; Spampinato, S1
Cross, AJ; Green, AR; Misra, A; Murray, TK; Snape, MF1
Chaney, SF; Hurst, G; Kane, JM; Kehne, JH; McCloskey, TC; Petty, MA; Senyah, Y; White, HS; Wolf, HH; Zobrist, R1
Caccia, S; Cagnotto, A; Fracasso, C; Ghia, M; Grossi, G; Mennini, T; Nacca, A; Roma, G1
Ebinger, G; Khan, GM; Michotte, Y; Smolders, I1
Canger, R; Henriksen, O; Karolchyk, MA; Pålhagen, S; Rivière, ME; van Parys, JA1
Bailey, L; Dunner, DL; Laird, LK; Seabolt, JL; Sussman, N; Zajecka, J1
Chidester, C; Duchamp, DJ; Gall, M; Lahti, RA; Rudzik, AD; Scahill, T1
Kamdar, BV; Moffett, RB; Von Voigtlander, PF1
Abdallah, A; Braun, DL; Chaney, SF; Dudley, MW; Kane, JM; Kehne, JH; Ketteler, HJ; Miller, FP; Ogden, AM; Senyah, Y1
Junnarkar, AY; Patnaik, GK; Shrotri, DS; Singh, PP1
Ashton, D; Clincke, GH; Fransen, J; Heeres, J; Janssen, PA1
Bastide, J; Bastide, P; Coudert, P; Couquelet, JM; Rubat, C; Tronche, P1
Kadaba, PK1
Egilmez, S; Itil, TM; Marasa, J; Polvan, N; Saletu, B1
Achari, G; Ahmad, A; Vohra, MM1
Bennett, JW; Ma, OH; Orth, RE; Young, L1

Reviews

9 review(s) available for triazoles and Seizures

ArticleYear
An Important Potential Anti-Epileptic/Anticonvulsant Active Group: A Review of 1,2,4-Triazole Groups and Their Action.
    Drug research, 2022, Volume: 72, Issue:3

    Topics: Anticonvulsants; Epilepsy; Humans; Seizures; Triazoles

2022
Efficacy and safety of rufinamide as adjunctive therapy in patients with Lennox Gastaut syndrome: A systematic review and Meta-analysis.
    Seizure, 2021, Volume: 91

    Topics: Anticonvulsants; Humans; Lennox Gastaut Syndrome; Randomized Controlled Trials as Topic; Seizures; Triazoles

2021
Exploring the Chemistry and Therapeutic Potential of Triazoles: A Comprehensive Literature Review.
    Mini reviews in medicinal chemistry, 2019, Volume: 19, Issue:16

    Topics: Humans; Infections; Inflammation; Neoplasms; Neurodegenerative Diseases; Oxidative Stress; Seizures; Triazoles

2019
3,4-DHQLO and Triazole and Its Related Analogues with Anticonvulsant Effects.
    Mini reviews in medicinal chemistry, 2016, Volume: 16, Issue:4

    Topics: Animals; Anticonvulsants; Drug Design; Epilepsy; Humans; Hydroquinones; Seizures; Structure-Activity Relationship; Triazoles

2016
1,2,4-triazole derivatives as potential scaffold for anticonvulsant activity.
    Central nervous system agents in medicinal chemistry, 2015, Volume: 15, Issue:1

    Topics: Animals; Anticonvulsants; Epilepsy; Humans; Seizures; Structure-Activity Relationship; Triazoles

2015
Rufinamide: a new antiepileptic medication for the treatment of seizures associated with lennox-gastaut syndrome.
    The Annals of pharmacotherapy, 2010, Volume: 44, Issue:4

    Topics: Aged; Anticonvulsants; Chemistry, Pharmaceutical; Child; Clinical Trials, Phase III as Topic; Counseling; Drug Resistance; Epilepsies, Partial; Epilepsy; Humans; Off-Label Use; Randomized Controlled Trials as Topic; Seizures; Syndrome; Triazoles

2010
Rufinamide from clinical trials to clinical practice in the United States and Europe.
    Epileptic disorders : international epilepsy journal with videotape, 2011, Volume: 13 Suppl 1

    Topics: Anticonvulsants; Child; Child, Preschool; Europe; Humans; Intellectual Disability; Lennox Gastaut Syndrome; Randomized Controlled Trials as Topic; Seizures; Spasms, Infantile; Treatment Outcome; Triazoles; United States

2011
Rufinamide.
    CNS drugs, 2006, Volume: 20, Issue:9

    Topics: Animals; Anticonvulsants; Clinical Trials as Topic; Humans; Seizures; Triazoles

2006
Six-year perspectives on the safety and tolerability of nefazodone.
    The Journal of clinical psychiatry, 2002, Volume: 63 Suppl 1

    Topics: Age Factors; Antidepressive Agents, Second-Generation; Body Weight; Chronic Disease; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; Male; Obesity; Piperazines; Priapism; Seizures; Sexual Dysfunctions, Psychological; Suicide; Triazoles

2002

Trials

3 trial(s) available for triazoles and Seizures

ArticleYear
Real-world data on rufinamide treatment in patients with Lennox-Gastaut syndrome: Results from a European noninterventional registry study.
    Epilepsy & behavior : E&B, 2017, Volume: 76

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Ethnicity; Europe; European Union; Female; Humans; Lennox Gastaut Syndrome; Male; Registries; Seizures; Sleep Stages; Treatment Outcome; Triazoles

2017
A randomized, double-blind, placebo-controlled, parallel-group study of rufinamide as adjunctive therapy for refractory partial-onset seizures.
    Epilepsia, 2011, Volume: 52, Issue:2

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Double-Blind Method; Drug Resistance; Epilepsies, Partial; Humans; Middle Aged; Sample Size; Seizures; Triazoles; Young Adult

2011
Rufinamide: a double-blind, placebo-controlled proof of principle trial in patients with epilepsy.
    Epilepsy research, 2001, Volume: 43, Issue:2

    Topics: Adult; Anticonvulsants; Double-Blind Method; Drug Therapy, Combination; Epilepsy; Female; Half-Life; Humans; Incidence; Male; Middle Aged; Nervous System Diseases; Seizures; Triazoles

2001

Other Studies

103 other study(ies) available for triazoles and Seizures

ArticleYear
Discovery of 7-alkyloxy- [1,2,4] triazolo[1,5-a] pyrimidine derivatives as selective positive modulators of GABA
    Bioorganic chemistry, 2022, Volume: 119

    Topics: Animals; Anticonvulsants; Cells, Cultured; Dose-Response Relationship, Drug; Drug Discovery; Electroshock; Epilepsy; Male; Mice; Mice, Inbred Strains; Molecular Structure; Neurons; Pentylenetetrazole; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Structure-Activity Relationship; Triazoles

2022
Therapeutic Drug Monitoring for Rufinamide in Japanese Patients With Epilepsy: Focus on Drug Interactions, Tolerability, and Clinical Effectiveness.
    Therapeutic drug monitoring, 2022, 08-01, Volume: 44, Issue:4

    Topics: Anticonvulsants; Drug Interactions; Drug Monitoring; Epilepsy; Humans; Japan; Retrospective Studies; Seizures; Treatment Outcome; Triazoles

2022
Design, synthesis, molecular docking and pharmacological evaluation of novel triazine-based triazole derivatives as potential anticonvulsant agents.
    Bioorganic & medicinal chemistry letters, 2022, 12-01, Volume: 77

    Topics: Anticonvulsants; Electroshock; Humans; Molecular Docking Simulation; Molecular Structure; Pentylenetetrazole; Seizures; Structure-Activity Relationship; Triazines; Triazoles

2022
A single-center SCN8A-related epilepsy cohort: clinical, genetic, and physiologic characterization.
    Annals of clinical and translational neurology, 2019, Volume: 6, Issue:8

    Topics: Cell Culture Techniques; Child; Cohort Studies; Epilepsy; Female; HEK293 Cells; Humans; Infant; Infant, Newborn; Male; Mutation; NAV1.6 Voltage-Gated Sodium Channel; Oxcarbazepine; Pyridines; Seizures; Sodium Channels; Triazoles

2019
Rufinamide efficacy and association with phenotype and genotype in children with intractable epilepsy: A retrospective single center study.
    Epilepsy research, 2020, Volume: 168

    Topics: Anticonvulsants; Child; Child, Preschool; Drug Resistant Epilepsy; Epilepsy; Female; Genotype; Humans; Infant; Lennox Gastaut Syndrome; Male; Phenotype; Retrospective Studies; Seizures; Triazoles

2020
Caffeine Exacerbates Postictal Hypoxia.
    Neuroscience, 2019, 12-01, Volume: 422

    Topics: Adenosine; Animals; CA1 Region, Hippocampal; Caffeine; Dose-Response Relationship, Drug; Hypoxia; Kindling, Neurologic; Male; Oxygen; Phenethylamines; Pyrimidines; Rats; Receptors, Adenosine A2; Seizures; Triazoles

2019
Design, Synthesis and Biological Activity of Some 4, 5-Disubstituted-2, 4- Dihydro-3H-1, 2, 4- Triazole-3-Thione Derivatives.
    Central nervous system agents in medicinal chemistry, 2019, Volume: 19, Issue:3

    Topics: Animals; Anticonvulsants; Drug Design; Male; Mice; Seizures; Thiones; Triazoles

2019
Screening of Some Novel 4, 5 Disubstituted 1, 2, 4-Triazole-3-thiones for Anticonvulsant Activity.
    Central nervous system agents in medicinal chemistry, 2020, Volume: 20, Issue:1

    Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Ataxia; Convulsants; Drug Evaluation, Preclinical; Electroshock; Male; Mice; Molecular Docking Simulation; Pentylenetetrazole; Rotarod Performance Test; Seizures; Structure-Activity Relationship; Triazoles

2020
Anticonvulsant and neurotoxic effects of a novel 1,2,4-triazole-3-thione derivative (TPF-34) and its isobolographic interaction profile with classical antiepileptic drugs in mice.
    Pharmacological reports : PR, 2020, Volume: 72, Issue:1

    Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Male; Mice; Seizures; Time Factors; Tissue Distribution; Triazoles

2020
Rufinamide as add-on therapy in children with epileptic encephalopathies other than Lennox-Gastaut syndrome: A study of 34 patients.
    Epilepsy & behavior : E&B, 2020, Volume: 108

    Topics: Adolescent; Anticonvulsants; Argentina; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; Follow-Up Studies; Humans; Lennox Gastaut Syndrome; Male; Retrospective Studies; Seizures; Triazoles; Valproic Acid

2020
Anticonvulsant Effectiveness and Neurotoxicity Profile of 4-butyl-5-[(4-chloro-2-methylphenoxy)methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione (TPL-16) in Mice.
    Neurochemical research, 2021, Volume: 46, Issue:2

    Topics: Animals; Anticonvulsants; Carbamazepine; Drug Synergism; Male; Mice; Muscle Strength; Phenobarbital; Phenytoin; Rotarod Performance Test; Seizures; Thiones; Triazoles; Valproic Acid

2021
Synthesis of Novel Triazolyl/Oxadiazolyl/Thiadiazolyl-Piperazine as Potential Anticonvulsant Agents.
    Drug research, 2021, Volume: 71, Issue:4

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Female; Humans; Male; Mice; Oxadiazoles; Piperazine; Rats; Seizures; Structure-Activity Relationship; Thiadiazoles; Toxicity Tests, Acute; Triazoles

2021
How Can an Na
    Annals of neurology, 2021, Volume: 89, Issue:6

    Topics: Animals; Female; Lennox Gastaut Syndrome; Male; Mice; Mice, Inbred C57BL; Neurons; Seizures; Triazoles; Voltage-Gated Sodium Channel Blockers

2021
Effect of Chronic Administration of 5-(3-chlorophenyl)-4-Hexyl-2,4 -Dihydro-3
    International journal of molecular sciences, 2021, Mar-25, Volume: 22, Issue:7

    Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Cytochrome P-450 Enzyme System; Electroshock; Kidney; Liver; Male; Mice; Neurodegenerative Diseases; Permeability; Protein Isoforms; Seizures; Triazoles

2021
Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome.
    Scientific reports, 2017, 05-10, Volume: 7, Issue:1

    Topics: Action Potentials; Animals; Epilepsies, Myoclonic; Ion Channel Gating; Mice, Inbred C57BL; Mice, Knockout; NAV1.1 Voltage-Gated Sodium Channel; NAV1.6 Voltage-Gated Sodium Channel; Neurons; Pyramidal Cells; Pyridines; Seizures; Survival Analysis; Triazoles

2017
Molecular mechanism of action and safety of 5-(3-chlorophenyl)-4-hexyl-2,4-dihydro-3
    International journal of medical sciences, 2017, Volume: 14, Issue:8

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Hep G2 Cells; Humans; Mice; Patch-Clamp Techniques; Seizures; Thiones; Triazoles; Voltage-Gated Sodium Channels

2017
Design, synthesis, in vivo and in silico evaluation of phenacyl triazole hydrazones as new anticonvulsant agents.
    Bioorganic chemistry, 2018, Volume: 78

    Topics: Animals; Anticonvulsants; Biological Availability; Drug Design; Hydrazones; Injections, Intraperitoneal; Male; Mice; Molecular Docking Simulation; Molecular Structure; Motor Activity; Pentylenetetrazole; Seizures; Triazoles

2018
Neuropharmacological and molecular docking studies of xanthones from Swertia corymbosa.
    Journal of receptor and signal transduction research, 2018, Volume: 38, Issue:2

    Topics: Animals; Anticonvulsants; Anxiety; Electroshock; Epilepsy; Isoniazid; Male; Maze Learning; Mice; Molecular Docking Simulation; Motor Activity; Neuropharmacology; Rotarod Performance Test; Seizures; Serotonin; Swertia; Triazoles; Xanthones

2018
Neuromuscular anomalies following oral exposure to 3-nitro-1,2,4-triazol-5-one (NTO) in a one-generation study with Japanese quail (Coturnix japonica).
    Journal of toxicology and environmental health. Part A, 2018, Volume: 81, Issue:15

    Topics: Administration, Oral; Animals; Coturnix; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Explosive Agents; Female; Male; Nitro Compounds; Reproduction; Seizures; Toxicity Tests, Acute; Triazoles

2018
Three children with Lennox-Gastaut syndrome presenting long-term good seizure outcome under rufinamide treatment.
    No to hattatsu = Brain and development, 2017, Volume: 49, Issue:1

    Topics: Anticonvulsants; Child; Child, Preschool; Female; Humans; Infant; Lennox Gastaut Syndrome; Male; Seizures; Time Factors; Treatment Outcome; Triazoles

2017
Synthesis and anticonvulsant screening of 1,2,4-triazole derivatives.
    Pharmacological reports : PR, 2018, Volume: 70, Issue:6

    Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroshock; Male; Mice; Rats; Rats, Sprague-Dawley; Seizures; Triazoles; X-Ray Diffraction

2018
Development of the 1,2,4-triazole-based anticonvulsant drug candidates acting on the voltage-gated sodium channels. Insights from in-vivo, in-vitro, and in-silico studies.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2019, Mar-01, Volume: 129

    Topics: Animals; Anticonvulsants; Cell Line; Cell Line, Tumor; Cell Membrane Permeability; Computer Simulation; Electroshock; HEK293 Cells; Hep G2 Cells; Humans; Mice; Molecular Docking Simulation; Receptors, GABA-A; Seizures; Triazoles; Voltage-Gated Sodium Channels

2019
Novel fused 1,2,3-triazolo-benzodiazepine derivatives as potent anticonvulsant agents: design, synthesis, in vivo, and in silico evaluations.
    Molecular diversity, 2020, Volume: 24, Issue:1

    Topics: Anticonvulsants; Benzodiazepines; Binding Sites; Chemistry Techniques, Synthetic; Drug Design; GABA-A Receptor Antagonists; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Protein Binding; Quantitative Structure-Activity Relationship; Receptors, GABA-A; Seizures; Triazoles

2020
Synthesis and evaluation of the anticonvulsant activity of 8-alkoxy-4,5-dihydrobenzo[b][1,2,4]triazolo[4,3-d][1,4]thiazepine derivatives.
    Journal of enzyme inhibition and medicinal chemistry, 2014, Volume: 29, Issue:2

    Topics: Animals; Anticonvulsants; Computational Biology; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Mice; Molecular Structure; Rotarod Performance Test; Seizures; Thiazepines; Triazoles

2014
Synthesis and anticonvulsant activity evaluation of 4-(2-alkoxy-phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-ones in various experimental seizure models in mice.
    Drug research, 2013, Volume: 63, Issue:6

    Topics: Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Mice; Seizures; Triazoles

2013
Design, synthesis and anticonvulsant activity evaluation of novel 4-(4-substitutedphenyl)-3-methyl-1H-1,2,4-triazol-5(4H)-ones.
    Drug research, 2014, Volume: 64, Issue:1

    Topics: Animals; Anticonvulsants; Carbamazepine; Convulsants; Drug Design; Drug Evaluation, Preclinical; Electroshock; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mice; Pentylenetetrazole; Postural Balance; Seizures; Structure-Activity Relationship; Triazoles

2014
Design, synthesis and evaluation of the antidepressant and anticonvulsant activities of triazole-containing quinolinones.
    European journal of medicinal chemistry, 2014, Feb-12, Volume: 73

    Topics: Animals; Anticonvulsants; Antidepressive Agents; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Electroshock; Exploratory Behavior; Male; Mice; Mice, Inbred Strains; Molecular Structure; Quinolones; Rotarod Performance Test; Seizures; Swimming; Triazoles

2014
Synthesis, receptor affinity and effect on pentylenetetrazole-induced seizure threshold of novel benzodiazepine analogues: 3-Substituted 5-(2-phenoxybenzyl)-4H-1,2,4-triazoles and 2-amino-5-(phenoxybenzyl)-1,3,4-oxadiazoles.
    Bioorganic & medicinal chemistry, 2014, Mar-15, Volume: 22, Issue:6

    Topics: Animals; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Structure; Oxadiazoles; Pentylenetetrazole; Receptors, GABA-A; Seizures; Structure-Activity Relationship; Triazoles

2014
Synthesis of some novel 1,2,4-triazol-3-one derivatives bearing the salicyl moiety and their anticonvulsant activities.
    Archiv der Pharmazie, 2014, Volume: 347, Issue:6

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Design; Electroshock; Mice; Molecular Structure; Salicylates; Seizures; Structure-Activity Relationship; Time Factors; Triazoles

2014
Antiepileptic activity of preferential inhibitors of persistent sodium current.
    Epilepsia, 2014, Volume: 55, Issue:8

    Topics: Acetanilides; Animals; Anticonvulsants; Cells, Cultured; Female; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; NAV1.2 Voltage-Gated Sodium Channel; Neurons; Piperazines; Pyridines; Ranolazine; Seizures; Sodium Channel Blockers; Triazoles

2014
Successful Treatment of Refractory Seizures With Rufinamide in Children With Schizencephaly: Report of 3 Cases.
    Journal of child neurology, 2015, Volume: 30, Issue:8

    Topics: Anticonvulsants; Child; Electroencephalography; Humans; Magnetic Resonance Imaging; Male; Schizencephaly; Seizures; Triazoles

2015
Studies on the anticonvulsant activity and influence on GABA-ergic neurotransmission of 1,2,4-triazole-3-thione- based compounds.
    Molecules (Basel, Switzerland), 2014, Jul-31, Volume: 19, Issue:8

    Topics: Animals; Anticonvulsants; Disease Models, Animal; GABA Agents; Male; Mice; Seizures; Synaptic Transmission; Toxicity Tests; Triazoles

2014
Studies on the anticonvulsant activity of 4-alkyl-1,2,4-triazole-3-thiones and their effect on GABAergic system.
    European journal of medicinal chemistry, 2014, Oct-30, Volume: 86

    Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Male; Mice; Molecular Structure; Receptors, GABA-A; Seizures; Structure-Activity Relationship; Triazoles

2014
Synthesis and Anticonvulsant Activity Evaluation of 4-Phenyl-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one and Its Derivatives.
    Archiv der Pharmazie, 2015, Volume: 348, Issue:8

    Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Brain; Disease Models, Animal; Drug Design; Electroshock; Mice; Molecular Structure; Motor Activity; Pentylenetetrazole; Quinazolinones; Rotarod Performance Test; Seizures; Structure-Activity Relationship; Time Factors; Triazoles

2015
BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice.
    Nature neuroscience, 2015, Volume: 18, Issue:10

    Topics: Animals; Azepines; Blotting, Western; Cells, Cultured; Chromatin Immunoprecipitation; Female; Immunohistochemistry; Male; Memory; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Neurons; Nuclear Proteins; Polymerase Chain Reaction; RNA, Small Interfering; Seizures; Transcription Factors; Transcriptional Activation; Transfection; Triazoles

2015
Synthesis and Some Reactions of 1-aryl-4-acetyl-5-methyl-1,2,3-triazole Derivatives with Anticonvulsant Activity.
    Mini reviews in medicinal chemistry, 2016, Volume: 16, Issue:11

    Topics: Animals; Anticonvulsants; Azepines; Chalcones; Chemistry Techniques, Synthetic; Male; Methylation; Mice; Seizures; Sonication; Structure-Activity Relationship; Triazoles

2016
Aggravation of atonic seizures by rufinamide: A case report.
    Brain & development, 2016, Volume: 38, Issue:7

    Topics: Anticonvulsants; Benzodiazepines; Brain; Child; Clobazam; Drug Resistant Epilepsy; Drug Therapy, Combination; Electroencephalography; Humans; Levetiracetam; Male; Piracetam; Seizures; Triazoles; Valproic Acid

2016
Rufinamide in children and adults in routine clinical practice.
    Acta neurologica Scandinavica, 2017, Volume: 135, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Child; Epilepsy, Generalized; Female; Humans; Lennox Gastaut Syndrome; Male; Middle Aged; Seizures; Triazoles; Vomiting; Weight Loss

2017
Preliminary Pharmacological Screening of Some Thiosemicarbazide, s-triazole, and Thiadiazole Derivatives.
    CNS & neurological disorders drug targets, 2016, Volume: 15, Issue:6

    Topics: Analgesics; Animals; Anxiety; Body Temperature; Central Nervous System Agents; Depression; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Mice; Molecular Structure; Motor Activity; Nociceptive Pain; Seizures; Semicarbazides; Sleep; Thiadiazoles; Triazoles

2016
Alcohol-induced retrograde memory impairment in rats: prevention by caffeine.
    Psychopharmacology, 2008, Volume: 201, Issue:3

    Topics: Adenosine A2 Receptor Antagonists; Amnesia, Retrograde; Animals; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ethanol; Exploratory Behavior; Habituation, Psychophysiologic; Injections, Intraperitoneal; Male; Odorants; Pentylenetetrazole; Phosphodiesterase 5 Inhibitors; Purinones; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Recognition, Psychology; Seizures; Smell; Time Factors; Triazines; Triazoles; Wood

2008
Alternaria infectoria brain abscess in a child with chronic granulomatous disease.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2009, Volume: 28, Issue:4

    Topics: Alternaria; Antifungal Agents; Brain; Brain Abscess; Caspofungin; Child, Preschool; Echinocandins; Fatal Outcome; Granulomatous Disease, Chronic; Humans; Lipopeptides; Male; Mycoses; Pyrimidines; Radiography; RNA, Fungal; RNA, Ribosomal, 5.8S; Seizures; Triazoles; Voriconazole

2009
The role of adenosine A(1) receptors in mediating the inhibitory effects of low frequency stimulation of perforant path on kindling acquisition in rats.
    Neuroscience, 2009, Feb-18, Volume: 158, Issue:4

    Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Biophysics; Cyclic AMP; Electric Stimulation; Excitatory Postsynaptic Potentials; Hippocampus; Kindling, Neurologic; Male; Neural Inhibition; Perforant Pathway; Rats; Rats, Wistar; Receptor, Adenosine A1; Seizures; Time Factors; Triazines; Triazoles; Xanthines

2009
Effectiveness and tolerability of rufinamide in children and adults with refractory epilepsy: first European experience.
    Epilepsy & behavior : E&B, 2009, Volume: 14, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Resistance; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Europe; Female; Humans; Infant; Male; Middle Aged; Orphan Drug Production; Retrospective Studies; Seizures; Treatment Outcome; Triazoles; Young Adult

2009
Evaluation of anticonvulsant activity of QUAN-0806 in various murine experimental seizure models.
    Die Pharmazie, 2009, Volume: 64, Issue:4

    Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Convulsants; Electroshock; Enzyme Activation; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Postural Balance; Quinolines; Seizures; Synaptic Transmission; Triazoles

2009
Isolated cerebral aspergilloma in a young immunocompetent patient.
    Practical neurology, 2009, Volume: 9, Issue:3

    Topics: Adult; Amphotericin B; Antifungal Agents; Aspergillosis; Brain Edema; Female; Humans; Muscle Weakness; Pyrimidines; Seizures; Treatment Outcome; Triazoles; Voriconazole

2009
Rufinamide: Further evaluation is needed in Lennox-Gastaut syndrome.
    Prescrire international, 2008, Volume: 17, Issue:96

    Topics: Adult; Child; Clinical Trials as Topic; Drug Approval; Epilepsy; Europe; Humans; Orphan Drug Production; Seizures; Triazoles

2008
The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment of cognitive dysfunction.
    Bioorganic & medicinal chemistry letters, 2009, Oct-15, Volume: 19, Issue:20

    Topics: Animals; Anticonvulsants; Benzodiazepines; Cell Line; Cognition Disorders; Disease Models, Animal; Drug Discovery; Drug Inverse Agonism; GABA-A Receptor Agonists; Humans; Imidazoles; Mice; Protein Binding; Rats; Receptors, GABA-A; Seizures; Structure-Activity Relationship; Triazoles

2009
Caffeine and an adenosine A(2A) receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life.
    Journal of neurochemistry, 2010, Volume: 112, Issue:2

    Topics: Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Animals, Newborn; Caffeine; Disease Models, Animal; Disease Progression; Drug Administration Schedule; Glial Fibrillary Acidic Protein; Kainic Acid; Memory Disorders; Neurotoxicity Syndromes; Phosphodiesterase Inhibitors; Purines; Pyrimidines; Qa-SNARE Proteins; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Synapses; Synaptophysin; Synaptosomal-Associated Protein 25; Triazoles; Tritium; Xanthines

2010
Supporting the recommended paediatric dosing regimen for rufinamide in Lennox-Gastaut syndrome using clinical trial simulation.
    Journal of pharmacokinetics and pharmacodynamics, 2010, Volume: 37, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Computer Simulation; Drug Dosage Calculations; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Models, Statistical; Nonlinear Dynamics; Seizures; Syndrome; Triazoles

2010
Synthesis and anticonvulsant activity of a new 6-alkoxy-[1,2,4]triazolo[4,3-b]pyridazine.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:5

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Mice; Molecular Structure; Motor Activity; Pyridazines; Rotarod Performance Test; Seizures; Stereoisomerism; Structure-Activity Relationship; Triazoles

2010
Experience with rufinamide in a pediatric population: a single center's experience.
    Pediatric neurology, 2010, Volume: 43, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Pediatrics; Retrospective Studies; Seizures; Treatment Outcome; Triazoles; Young Adult

2010
Synthesis and anticonvulsant activity of 7-alkoxy-triazolo-[3, 4-b]benzo[d]thiazoles.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2010, Volume: 6, Issue:5

    Topics: Animals; Anticonvulsants; Benzothiazoles; Carbamazepine; Drug Evaluation, Preclinical; Electroshock; Mice; Motor Activity; Phenytoin; Seizures; Structure-Activity Relationship; Triazoles

2010
Anticonvulsant activity and toxicity evaluation of Cu(II) and Zn(II) metal complexes derived from triazole-quinoline ligands.
    Chemical & pharmaceutical bulletin, 2010, Volume: 58, Issue:12

    Topics: Animals; Anticonvulsants; Coordination Complexes; Copper; Ligands; Quinolines; Rats; Rats, Wistar; Seizures; Triazoles; Zinc

2010
Serum concentrations of rufinamide in children and adults with epilepsy: the influence of dose, age, and comedication.
    Therapeutic drug monitoring, 2011, Volume: 33, Issue:2

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Body Weight; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Intellectual Disability; Lennox Gastaut Syndrome; Male; Middle Aged; Seizures; Spasms, Infantile; Triazoles; Valproic Acid; Young Adult

2011
Synthesis and anticonvulsant activity of 7-phenyl-6,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones and their derivatives.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:7

    Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Electroshock; Isoniazid; Mice; Pentylenetetrazole; Pyrimidinones; Seizures; Semicarbazides; Structure-Activity Relationship; Triazoles

2011
Selective blockade of A(2A) receptor protects against neurotoxicity induced by kainic acid in young rats.
    Fundamental & clinical pharmacology, 2012, Volume: 26, Issue:4

    Topics: Adenosine A2 Receptor Antagonists; Animals; Brain; Catalase; Glutathione Peroxidase; Glutathione Transferase; Kainic Acid; Male; Neurotoxicity Syndromes; Oxidative Stress; Pyrimidines; Rats; Reactive Oxygen Species; Seizures; Triazoles

2012
[Sedative, hypnotic and anticonvulsive effects of an adenosine analogue WS090501].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2011, Volume: 46, Issue:6

    Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Anticonvulsants; Convulsants; Electroencephalography; Hypnotics and Sedatives; Male; Mice; Mice, Inbred ICR; Motor Activity; Pentylenetetrazole; Pyrimidines; Rats; Rats, Wistar; Seizures; Sleep; Triazoles; Xanthines

2011
Synthesis and biological evaluation of 9-alkoxy-6,7-dihydro-5H-benzo[c] [1,2,4]triazolo[4,3-a]azepines as potential anticonvulsant agents.
    Arzneimittel-Forschung, 2012, Volume: 62, Issue:4

    Topics: Animals; Anticonvulsants; Azepines; Convulsants; Electroshock; Mice; Pentylenetetrazole; Postural Balance; Seizures; Spectrophotometry, Infrared; Structure-Activity Relationship; Triazoles

2012
Effect of adenosine A2A receptor antagonist ZM241385 on amygdala-kindled seizures and progression of amygdala kindling.
    Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2012, Volume: 32, Issue:2

    Topics: Adenosine A2 Receptor Antagonists; Amygdala; Animals; Dose-Response Relationship, Drug; Male; Rats; Rats, Wistar; Receptor, Adenosine A2A; Seizures; Treatment Outcome; Triazines; Triazoles

2012
Synthesis and anticonvulsant activities of some triazolothiadiazole derivatives.
    Archiv der Pharmazie, 2012, Volume: 345, Issue:7

    Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Injections, Intraperitoneal; Mice; Mice, Inbred Strains; Molecular Structure; Seizures; Thiadiazoles; Triazoles

2012
Craniocerebral maduromycosis.
    Journal of neurosurgery. Pediatrics, 2012, Volume: 10, Issue:1

    Topics: Adolescent; Antifungal Agents; Bone Diseases; Brain Diseases; Female; Humans; India; Madurella; Magnetic Resonance Imaging; Mycetoma; Naphthalenes; Parietal Lobe; Pyrimidines; Scalp; Seizures; Terbinafine; Tomography, X-Ray Computed; Triazoles; Voriconazole

2012
Effect of 4-(4-bromophenyl)-5-(3-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione on the anticonvulsant action of different classical antiepileptic drugs in the mouse maximal electroshock-induced seizure model.
    European journal of pharmacology, 2012, Sep-05, Volume: 690, Issue:1-3

    Topics: Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Brain; Disease Models, Animal; Drug Interactions; Electroshock; Hand Strength; Male; Memory; Mice; Motor Activity; Muscle, Skeletal; Seizures; Thiones; Triazoles

2012
Relapsing cerebral aspergilloma associated with pregnancy.
    Clinical neurology and neurosurgery, 2013, Volume: 115, Issue:7

    Topics: Adult; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Brain; Central Nervous System Fungal Infections; Female; Humans; Infant, Newborn; Magnetic Resonance Imaging; Pregnancy; Pregnancy Complications, Infectious; Pyrimidines; Recurrence; Seizures; Triazoles; Voriconazole

2013
Rufinamide for refractory focal seizures: an open-label, multicenter European study.
    Seizure, 2013, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Europe; Female; Humans; Longitudinal Studies; Male; Middle Aged; Seizures; Treatment Outcome; Triazoles; Young Adult

2013
Effectiveness and tolerability of rufinamide in children and young adults with Lennox-Gastaut syndrome: a single center study in Korea.
    Clinical neurology and neurosurgery, 2013, Volume: 115, Issue:7

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Female; Humans; Intellectual Disability; Lennox Gastaut Syndrome; Male; Neurosurgical Procedures; Republic of Korea; Retrospective Studies; Seizures; Spasms, Infantile; Treatment Outcome; Triazoles; Young Adult

2013
Design, synthesis, and anticonvulsant activity evaluation of 4-(3-alkoxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-ones.
    Archiv der Pharmazie, 2013, Volume: 346, Issue:2

    Topics: Animals; Anticonvulsants; Drug Design; Electroshock; Mice; Mice, Inbred Strains; Molecular Structure; Neurotoxicity Syndromes; Seizures; Triazoles

2013
Synthesis and anticonvulsant activity evaluation of 5-phenyl-[1,2,4]triazolo[4,3-c]quinazolin-3-amines.
    Archiv der Pharmazie, 2013, Volume: 346, Issue:2

    Topics: Amines; Animals; Anticonvulsants; Drug Design; Electroshock; Mice; Mice, Inbred Strains; Molecular Structure; Neurotoxicity Syndromes; Quinazolines; Rotarod Performance Test; Seizures; Triazoles

2013
Synthesis, characterization and preliminary anticonvulsant evaluation of some 4-alkyl-1,2,4-triazoles.
    European journal of medicinal chemistry, 2013, Volume: 60

    Topics: Animals; Anticonvulsants; Electroshock; Male; Mice; Molecular Structure; Seizures; Triazoles

2013
Broad spectrum anticonvulsant activity of BW534U87: possible role of an adenosine-dependent mechanism.
    Pharmacology, biochemistry, and behavior, 2002, Volume: 74, Issue:1

    Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Amygdala; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Electroshock; Enzyme Inhibitors; Female; Kindling, Neurologic; Male; Mice; Pentylenetetrazole; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Seizures; Triazoles; Xanthines

2002
Design and synthesis of 4H-3-(2-phenoxy)phenyl-1,2,4-triazole derivatives as benzodiazepine receptor agonists.
    Bioorganic & medicinal chemistry, 2003, Mar-06, Volume: 11, Issue:5

    Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Drug Design; GABA-A Receptor Agonists; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mice; Models, Molecular; Molecular Conformation; Pentylenetetrazole; Postural Balance; Seizures; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Triazoles

2003
[Insulin shock, electro-, tetrazole, triazole convulsions and the peripheral vascular system].
    Therapie der Gegenwart, 1957, Volume: 96, Issue:9

    Topics: Cardiovascular Diseases; Cardiovascular System; Convulsive Therapy; Insulin Coma; Seizures; Sympathomimetics; Tetrazoles; Triazoles

1957
THE ANTICONVULSANT ACTIVITY OF 1,2,4-TRIAZOLES.
    Journal of medicinal and pharmaceutical chemistry, 1962, Volume: 5

    Topics: Anticonvulsants; Central Nervous System Stimulants; Pharmacology; Rats; Research; Seizures; Triazoles

1962
Seroquel, Serzone and seizures.
    Internal medicine journal, 2004, Volume: 34, Issue:3

    Topics: Adult; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Dibenzothiazepines; Drug Packaging; Female; Humans; Medication Errors; Piperazines; Quetiapine Fumarate; Seizures; Triazoles

2004
Interaction of loreclezole with conventional antiepileptic drugs in amygdala-kindled rats.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2004, Volume: 14, Issue:3

    Topics: Amygdala; Animals; Anticonvulsants; Avoidance Learning; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Kindling, Neurologic; Male; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Seizures; Triazoles

2004
Endogenous adenosine modulates epileptiform activity in rat hippocampus in a receptor subtype-dependent manner.
    The European journal of neuroscience, 2004, Volume: 19, Issue:9

    Topics: Adenosine; Animals; Animals, Newborn; Dihydropyridines; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Indoles; Maleimides; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Seizures; Theophylline; Time Factors; Triazines; Triazoles

2004
Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3alpha-androstanediol and 17beta-estradiol.
    Neuroscience, 2004, Volume: 129, Issue:1

    Topics: Androstane-3,17-diol; Animals; Aromatase Inhibitors; Chromatography; Convulsants; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estradiol; Finasteride; Hippocampus; Letrozole; Male; Mass Spectrometry; Mice; Nitriles; Organ Culture Techniques; Patch-Clamp Techniques; Pentylenetetrazole; Rats; Receptors, GABA-A; Seizures; Testosterone; Triazoles

2004
Pharmacodynamic and pharmacokinetic interaction studies of loreclezole with felbamate, lamotrigine, topiramate, and oxcarbazepine in the mouse maximal electroshock seizure model.
    Epilepsia, 2005, Volume: 46, Issue:3

    Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Electroshock; Felbamate; Fructose; Kindling, Neurologic; Lamotrigine; Male; Mice; Motor Activity; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Seizures; Topiramate; Triazines; Triazoles

2005
Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis.
    Epilepsy & behavior : E&B, 2005, Volume: 7, Issue:4

    Topics: Animals; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Ethosuximide; Kindling, Neurologic; Linear Models; Male; Mice; Pentylenetetrazole; Phenobarbital; Seizures; Triazoles; Valproic Acid

2005
Adenosine A1 and A2A receptors of hippocampal CA1 region have opposite effects on piriform cortex kindled seizures in rats.
    Seizure, 2006, Volume: 15, Issue:1

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Cerebral Cortex; Electric Stimulation; Hippocampus; Kindling, Neurologic; Male; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptors, Purinergic P2; Seizures; Triazines; Triazoles; Xanthines

2006
Isobolographic analysis of interactions between loreclezole and conventional antiepileptic drugs in the mouse maximal electroshock-induced seizure model.
    Naunyn-Schmiedeberg's archives of pharmacology, 2006, Volume: 373, Issue:2

    Topics: Algorithms; Animals; Anticonvulsants; Avoidance Learning; Brain; Drug Interactions; Dyskinesia, Drug-Induced; Electroshock; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Male; Memory; Mice; Psychomotor Performance; Seizures; Triazoles

2006
Antibacterial, antifungal and anticonvulsant evaluation of novel newly synthesized 1-[2-(1H-tetrazol-5-yl)ethyl]-1H-benzo[d][1, 2,3]triazoles.
    Archives of pharmacal research, 2006, Volume: 29, Issue:7

    Topics: Animals; Anti-Bacterial Agents; Anticonvulsants; Antifungal Agents; Bacillus subtilis; Candida albicans; Electroshock; Mice; Microbial Sensitivity Tests; Seizures; Triazoles

2006
The role of adenosine A1 and A2A receptors of entorhinal cortex on piriform cortex kindled seizures in rats.
    Pharmacological research, 2007, Volume: 56, Issue:2

    Topics: Adenosine; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Entorhinal Cortex; Kindling, Neurologic; Male; Microinjections; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Seizures; Triazines; Triazoles; Xanthines

2007
Synthesis and anticonvulsant evaluation of 4-(4-alkoxylphenyl)-3-ethyl-4H-1,2,4-triazoles as open-chain analogues of 7-alkoxyl-4,5-dihydro[1,2,4]triazolo[4,3-a]quinolines.
    Bioorganic & medicinal chemistry, 2007, Nov-01, Volume: 15, Issue:21

    Topics: Animals; Anticonvulsants; Mice; Mice, Inbred C57BL; Quinolines; Seizures; Strychnine; Triazoles

2007
The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models.
    Epilepsia, 2008, Volume: 49, Issue:7

    Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Injections, Intraperitoneal; Mice; Phenobarbital; Phenytoin; Rats; Rats, Sprague-Dawley; Seizures; Severity of Illness Index; Triazoles; Valproic Acid

2008
Synthesis and biological activities of some 3,6-disubstituted thiazolo[3,2-b][1,2,4]triazoles.
    Journal of pharmaceutical sciences, 1995, Volume: 84, Issue:4

    Topics: Animals; Anticonvulsants; Antifungal Agents; Candida; Electroshock; Male; Mice; Microbial Sensitivity Tests; Pentylenetetrazole; Seizures; Spectrophotometry, Infrared; Thiazoles; Triazoles

1995
Synthesis and anticonvulsant activity of some new 1,1-bis(4-substituted 1,2,4-triazoline-5-thione-3-yl)-2-methylbutanes.
    Farmaco (Societa chimica italiana : 1989), 1995, Volume: 50, Issue:3

    Topics: Animals; Anticonvulsants; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Pentylenetetrazole; Seizures; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Thiones; Triazoles

1995
Platelet-activating factor is a messenger in the electroconvulsive shock-induced transcriptional activation of c-fos and zif-268 in hippocampus.
    Journal of neuroscience research, 1994, Volume: 37, Issue:1

    Topics: Animals; Azepines; Base Sequence; DNA-Binding Proteins; Early Growth Response Protein 1; Electroshock; Gene Expression Regulation; Hippocampus; Immediate-Early Proteins; Male; Microsomes; Molecular Sequence Data; Neuronal Plasticity; Platelet Activating Factor; Platelet Membrane Glycoproteins; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Seizures; Synaptic Membranes; Tetrazoles; Thienopyridines; Transcription Factors; Transcription, Genetic; Triazoles; Zinc Fingers

1994
5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents.
    Journal of medicinal chemistry, 1994, Jan-07, Volume: 37, Issue:1

    Topics: Animals; Anticonvulsants; Cerebellum; Cerebral Cortex; Chlorides; Electroshock; Flumazenil; Male; Mice; Molecular Structure; Muscle Spasticity; Paralysis; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship; Strychnine; Triazoles

1994
Synthesis of aminothienopyrimidine and thienotriazolopyrimidine derivatives as potential anticonvulsant agents.
    Die Pharmazie, 1996, Volume: 51, Issue:1

    Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry, Physical; Male; Mice; Motor Activity; Pyrimidines; Rats; Seizures; Thiophenes; Triazoles

1996
A behavioural and neurochemical study in rats of the pharmacology of loreclezole, a novel allosteric modulator of the GABAA receptor.
    Neuropharmacology, 1996, Volume: 35, Issue:9-10

    Topics: Allosteric Regulation; Animals; Behavior, Animal; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlormethiazole; Dose-Response Relationship, Drug; GABA Modulators; Hypnotics and Sedatives; Male; Muscle Relaxation; Pentobarbital; Picrotoxin; Rats; Receptors, GABA-A; Seizures; Sesterterpenes; Triazoles

1996
Preclinical characterization of MDL 27,192 as a potential broad spectrum anticonvulsant agent with neuroprotective properties.
    Epilepsy research, 1997, Volume: 27, Issue:1

    Topics: Animals; Anticonvulsants; Cerebral Infarction; Craniocerebral Trauma; Electroshock; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Kindling, Neurologic; Male; Mice; Mice, Inbred DBA; Motor Activity; Neuroprotective Agents; Rats; Rats, Inbred F344; Rats, Inbred SHR; Rats, Sprague-Dawley; Seizures; Triazoles; Valproic Acid

1997
Acid-catalysed hydrolysis and benzodiazepine-like properties of 5-(dialkylamino)- and 5-(alkylthio)-substituted 8-chloro-6-phenyl-6H-[1,2,4]triazolol[4,3-a][1,5]benzodiazepines in mice.
    The Journal of pharmacy and pharmacology, 1998, Volume: 50, Issue:7

    Topics: Administration, Oral; Animals; Anticonvulsants; Benzodiazepines; Brain; Gastric Acid; Hydrolysis; Male; Mice; Pentylenetetrazole; Receptors, GABA-A; Seizures; Triazoles

1998
Anticonvulsant effect and neurotransmitter modulation of focal and systemic 2-chloroadenosine against the development of pilocarpine-induced seizures.
    Neuropharmacology, 2000, Volume: 39, Issue:12

    Topics: 2-Chloroadenosine; Animals; Anticonvulsants; Behavior, Animal; Electroencephalography; Electrophysiology; Hippocampus; Injections; Male; Muscarinic Agonists; Neurotransmitter Agents; Pilocarpine; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Wistar; Seizures; Triazoles

2000
Novel anxiolytic agents derived from alpha-amino-alpha-phenyl-o-tolyl-4H-triazoles and -imidazoles.
    Journal of medicinal chemistry, 1978, Volume: 21, Issue:6

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Brain; Crystallography; Hypnotics and Sedatives; Imidazoles; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Models, Molecular; Molecular Conformation; Muscle Relaxation; Nicotine; Pentylenetetrazole; Rats; Seizures; Semicarbazides; Triazoles

1978
Central nervous system depressants. 13. s-Triazolo-1,5-benzodiazepin-5-ones.
    Journal of medicinal chemistry, 1976, Volume: 19, Issue:1

    Topics: Animals; Benzodiazepinones; Central Nervous System; Depression, Chemical; Male; Mice; Nicotine; Pentylenetetrazole; Reflex; Seizures; Strychnine; Triazoles

1976
MDL 27,531 selectively reverses strychnine-induced seizures in mice.
    British journal of pharmacology, 1992, Volume: 106, Issue:4

    Topics: Administration, Oral; Animals; Electric Stimulation; Hypnotics and Sedatives; Injections, Intraperitoneal; Male; Mice; Receptors, Glycine; Receptors, Neurotransmitter; Seizures; Strychnine; Triazoles

1992
Neuropsychopharmacological study of 2,4-dihydro[1,2,4]triazolo[3,4-c][1,4]benzothiazine-1-one (IDPH-791).
    Pharmacological research, 1992, Volume: 26, Issue:2

    Topics: Administration, Oral; Animals; Brain; Hypnosis; Injections, Intraperitoneal; Lethal Dose 50; Mephenesin; Mice; Motor Activity; Muscle Relaxants, Central; Muscle Relaxation; Paralysis; Rabbits; Rats; Rats, Wistar; Seizures; Thiazines; Triazoles

1992
In vivo studies on the mechanism of action of the broad spectrum anticonvulsant loreclezole.
    Epilepsy research, 1992, Volume: 11, Issue:1

    Topics: Animals; Anticonvulsants; Diazepam; Electric Stimulation; Kindling, Neurologic; Male; Pentobarbital; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Triazoles

1992
Synthesis and pharmacological evaluation of 6,8-diaryl 1,2,4-triazolo [4,3,-b] and 1,2,3,4,-tetrazolo [1,5-b] pyridazines.
    Farmaco (Societa chimica italiana : 1989), 1990, Volume: 45, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Azoles; Behavior, Animal; Bicuculline; Chemical Phenomena; Chemistry; Electroshock; Hypnotics and Sedatives; Mice; Motor Activity; Pentylenetetrazole; Pyridazines; Seizures; Tetrazoles; Triazoles

1990
Triazolines. 14. 1,2,3-Triazolines and triazoles, a new class of anticonvulsants. Drug design and structure-activity relationships.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:1

    Topics: Animals; Anticonvulsants; Electroshock; Mice; Seizures; Structure-Activity Relationship; Triazoles

1988
Anxiolytic effects of a new triazolobenzodiazepine, U-31,889.
    Current therapeutic research, clinical and experimental, 1973, Volume: 15, Issue:9

    Topics: Adult; Animals; Anxiety; Behavior, Animal; Benzodiazepinones; Blood Circulation; Central Nervous System; Computers; Depression; Dogs; Electroencephalography; Female; Flurazepam; Humans; Hypnotics and Sedatives; Leukocyte Count; Male; Middle Aged; Movement Disorders; Respiration; Seizures; Sleep; Sleep Initiation and Maintenance Disorders; Tranquilizing Agents; Triazoles

1973
Pharmacological study of 1-(beta-phenylethyl) triazolo (4,5-c) pyridine hydrochloride, a tranquillizing agent.
    Japanese journal of pharmacology, 1967, Volume: 17, Issue:4

    Topics: Aggression; Analgesia; Anesthesia; Animals; Anticonvulsants; Autonomic Nervous System; Avoidance Learning; Behavior, Animal; Blood Pressure; Body Temperature; Central Nervous System; Chlorpromazine; Electroencephalography; Female; Humans; Ileum; Male; Mice; Motor Activity; Neuromuscular Junction; Pentobarbital; Pyridines; Rats; Reflex; Reserpine; Respiration; Seizures; Sleep; Tranquilizing Agents; Triazoles; Uterus

1967
Centrally acting isosteric Mannich bases.
    Journal of pharmaceutical sciences, 1968, Volume: 57, Issue:10

    Topics: Animals; Azoles; Benzimidazoles; Chemistry, Pharmaceutical; Cyanosis; Indoles; Mice; Motor Activity; Piperazines; Piperidines; Pyrrolidines; Seizures; Triazoles

1968