triazoles has been researched along with Seizures in 115 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 8 (6.96) | 18.7374 |
1990's | 12 (10.43) | 18.2507 |
2000's | 26 (22.61) | 29.6817 |
2010's | 55 (47.83) | 24.3611 |
2020's | 14 (12.17) | 2.80 |
Authors | Studies |
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Liu, D; Wang, Y | 1 |
Chen, L; Hou, Z; Huang, L; Li, X; Lian, C; Meng, Q; Wang, Y; Wu, J; Yu, H; Zhang, C | 1 |
Imai, K; Inoue, Y; Kagawa, Y; Takahashi, Y; Usui, N; Yamamoto, Y | 1 |
Abou-Krisha, MM; Alhamzani, AG; Jeon, BH; Prashanth, MK; Raghu, MS; Yogesh Kumar, K; Yousef, TA | 1 |
Abou Tayoun, A; Goldberg, EM; Zaman, T | 1 |
Bozarth, XL; Oesch, G | 1 |
Gom, RC; Phillips, TJ; Teskey, GC; Wolff, MD | 1 |
Jain, J; Singh, UK; Verma, KK | 2 |
Bojar, H; Florek-Łuszczki, M; Lepiech, J; Plech, T; Walczak, A; Wróblewska-Łuczka, P; Zagaja, M; Łuszczki, JJ | 1 |
Caraballo, RH; Espeche, A; Fasulo, L; Galichio, S; Pociecha, J; Reyes, G; Semprino, M | 1 |
Drabik, M; Florek-Łuszczki, M; Głuszak, M; Jankiewicz, M; Kozińska, J; Plech, T; Plewa, Z; Wróblewska-Łuczka, P; Łuszczki, JJ | 1 |
Archana, A | 1 |
Chou, P; Hsueh, SW; Huang, CS; Kuo, CC; Lai, YC; Lin, TH; Lin, YC; Wang, RW; Yang, YC | 1 |
Andres-Mach, M; Cielecka-Piontek, J; Flieger, J; Makuch-Kocka, A; Pizoń, M; Plech, T; Śmiech, A; Zagaja, M | 1 |
Dawman, L; Panda, P; Panda, PK; Sharawat, IK | 1 |
Anderson, LL; George, AL; Hawkins, NA; Kearney, JA; Thompson, CH | 1 |
Gryboś, A; Głuch-Lutwin, M; Jóźwiak, K; Kaproń, B; Karcz, T; Mordyl, B; Nowak, G; Pająk, K; Paneth, A; Plech, T; Siwek, A; Tomczykowski, A; Wujec, M; Łuszczki, J | 1 |
Auvin, S; Brandt, C; McMurray, R; Nikanorova, M | 1 |
Ahangar, N; Dehestani, L; Emami, S; Hashemi, SM; Honarchian Masihi, P; Irannejad, H; Shakiba, A | 1 |
Mahendran, G; Vijayan, R | 1 |
Bannon, DI; Jackovitz, AM; Johnson, MS; Koistinen, KA; Lent, EM; Quinn, MJ | 1 |
Takahashi, Y; Takayama, R; Tsukamoto, K | 1 |
Dalkara, S; Kaynak, FB; Sari, S | 1 |
Cielecka-Piontek, J; Ciesla, LM; Gryboś, A; Kaproń, B; Karcz, T; Langner, E; Makuch-Kocka, A; Marciniak, S; Nowak, G; Paczkowska, M; Plech, T; Płazińska, A; Siwek, A; Szalast, K; Walczak, K; Łuszczki, JJ | 1 |
Jain, A; Piplani, P | 1 |
Asadi, M; Dehpour, AR; Ghasemi, JB; Larijani, B; Mahdavi, M; Mohammadi-Khanaposhtani, M; Rahimi, N; Ranjbar, PR; Shafaroodi, H; Shafie, A | 1 |
Deng, XQ; Quan, ZS; Song, MX; Wang, SB | 1 |
Cao, X; Deng, XQ; Quan, ZS; Shu, B; Wang, SB | 1 |
Cao, X; Liu, DC; Quan, ZS; Shu, B; Wang, SB; Zheng, Y | 1 |
Deng, XQ; Quan, ZS; Song, MX; Zheng, Y | 1 |
Ahmadi, F; Banafshe, HR; Mahmoodi, B; Mashayekh, S; Motaharian, D; Navidpour, L; Rahmanipour, N; Shafaroodi, H; Shafiee, A; Shahhosseini, S | 1 |
Akkaya, E; Doğan, IS; Kahveci, B; Menteşe, E; Ozel, A; Yılmaz, F | 1 |
Anderson, LL; Bush, WS; Frankel, WN; George, AL; Hawkins, NA; Kearney, JA; Nath, RD; Petersohn, AA; Rajamani, S; Thompson, CH; Vanoye, CG | 1 |
Coppola, G; Delli Pizzi, A; Loiacono, G; Rossi, A; Tartaro, A; Verrotti, A | 1 |
Kaproń, B; Kołaczkowski, M; Luszczki, JJ; Nowak, G; Paneth, A; Plech, T; Siwek, A; Wujec, M; Zołnierek, M | 1 |
Kaproń, B; Kołaczkowski, M; Luszczki, JJ; Nowak, G; Paneth, A; Plech, T; Siwek, A; Żołnierek, M | 1 |
Guan, LP; Quan, ZS | 1 |
Dhanda, A; Kamboj, VK; Ranjan, S; Verma, PK | 1 |
Guan, LP; Jin, P; Li, FN; Quan, ZS; Wang, SB; Zhang, HJ | 1 |
Allis, CD; Darnell, RB; Herre, M; Korb, E; Zucker-Scharff, I | 1 |
Abdelrazek, FM; Ayyad, RR; El-Farargy, AF; Nassar, EM | 1 |
Aydın, A; Aydınlı, N; Bektaş, G; Çalışkan, M; Özmen, M; Pembegül Yıldız, E; Tatlı, B | 1 |
Becerra, JL; Burcet, J; Cano, A; Falip, M; Fernández, S; Fossas, P; Jaraba, S; Miravet, E; Miró, J; Molins, A; Pico, G; Raspall, M; Santamarina, E; Toledo, M | 1 |
Hagel, D; Herbet, M; Izdebska, M; Jagiello-Wójtowicz, E; Kędzierska, E; Kosiek, S; Kuśmierz, E; Orzelska-Górka, J; Paneth, A; Piątkowska-Chmiel, I; Plech, T; Wujec, M | 1 |
Cormack, LK; Feinberg, LM; Schallert, K; Schallert, T; Spinetta, MJ; Stroud, C; Woodlee, MT | 1 |
Alves, AF; Anjos, J; de Hoog, GS; Estevão, H; Faria, E; Gonçalves, T; Hipolito, E; Morais, PV | 1 |
Fathollahi, Y; Jahanshahi, A; Javan, M; Mirnajafi-Zadeh, J; Mohammad-Zadeh, M; Motamedi, F; Noorbakhsh, SM | 1 |
Bast, T; Boor, R; Ernst, JP; Haberlandt, E; Kluger, G; Kurlemann, G; Makowski, C; Runge, U; Schneider, F | 1 |
Guan, LP; Jiang, Z; Piao, HR; Quan, ZS; Zhao, DH | 1 |
Bhavna, B; Kumar, K; Narayan, SK; Roopeshkumar, VR; Swaminathan, RP | 1 |
Achermann, G; Ballard, T; Buettelmann, B; Fischer, H; Gasser, R; Hernandez, MC; Knoflach, F; Knust, H; Koblet, A; Stadler, H; Thomas, AW; Trube, G; Waldmeier, P | 1 |
Agostinho, PM; Cognato, GP; Cunha, RA; Hockemeyer, J; Müller, CE; Souza, DO | 1 |
Critchley, DJ; Fuseau, E; Marchand, M | 1 |
Deng, XQ; Guan, LP; Quan, YC; Quan, ZS; Sui, X | 1 |
Wisniewski, CS | 1 |
Bergin, AM; Bourgeois, BF; Duffy, FH; Eksioglu, YZ; Gooty, VD; Kothare, SV; Libenson, M; Loddenkemper, T; Poduri, A; Rotenberg, A; Takeoka, M; Vendrame, M | 1 |
Bibbiani, F; Biton, V; Krauss, G; Mann, A; Narurkar, M; Perdomo, C; Vasquez-Santana, B | 1 |
Deng, XQ; Li, FN; Quan, ZS; Song, MX; Wei, CX | 1 |
Budagumpi, S; Didagi, S; Kulkarni, NV; Kurdekar, GS; Revankar, VK | 1 |
Boor, R; Brandt, C; Jürgens, U; Korn-Merker, E; May, TW; Rambeck, B | 1 |
Deng, XQ; Quan, LN; Quan, ZS; Song, MX; Wei, CX | 1 |
Bortolatto, CF; Jesse, CR; Nogueira, CW; Wilhelm, EA | 1 |
Arzimanoglou, A; Brown, LW; Flamini, R; Harrison, M; Kerr, M; Kluger, G; Kothare, S; Narurkar, M; Philip, S; Resnick, T | 1 |
Li, W; Zhang, JJ | 1 |
Han, RB; Peng, B; Piao, FY; Zhang, W; Zhang, WB | 1 |
Chen, X; Kang, H; Li, X; Liu, X; Liu, Z; Shu, K; Zhu, S | 1 |
Deng, XQ; Dong, ZQ; Quan, ZS; Shu, B; Song, MX; Wang, SB | 1 |
Goel, RS; Gupta, A; Jain, A; Kataria, R; Singh, S; Sinha, VD | 1 |
Luszczki, JJ; Plech, T; Wujec, M | 1 |
Fiehler, J; Gerloff, C; Kruetzelmann, A; Rosenkranz, M; Sobottka, I; Tolosa, E | 1 |
Anna Rita, M; Coppola, G; Curatolo, P; Isone, C; Kluger, G; Mueller, A; Parisi, P; Santoro, E; Verrotti, A; Zamponi, N | 1 |
Ko, TS; Lee, EH; Yum, MS | 1 |
Deng, XQ; Quan, ZS; Shu, B; Wang, SB; Zheng, Y | 1 |
Bian, M; Deng, XQ; Quan, ZS; Wang, SB; Zheng, Y | 1 |
Flieger, J; Luszczki, JJ; Pizoń, M; Plech, T; Wujec, M | 1 |
Brackenborough, KT; Duffy, C; Hagan, RM; Jones, SA; Morgan, PF; Pratt, GD; Sargent, RS; Southam, E; Stratton, SC | 1 |
Akbarzadeh, T; Khoshnoud, MJ; Shafaghi, B; Shafiee, A; Tabatabai, SA | 1 |
SICHENEDER, T | 1 |
AINSWORTH, C; EASTON, NR; GIBSON, WR; LIVEZEY, M; MORRISON, DE | 1 |
Burgess, N; Nigro, O; Shakib, S; Worthley, DL | 1 |
Borowicz, KK; Czuczwar, SJ; Sawiniec, A | 1 |
Etherington, LA; Frenguelli, BG | 1 |
Reddy, DS | 1 |
Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N | 3 |
Fathollahi, Y; Mirnajafi-Zadeh, J; Namvar, S; Rezvani, ME; Zeraati, M | 1 |
AnandaRajagopal, K; Murugesan, S; Rajasekaran, A | 1 |
Deeks, ED; Scott, LJ | 1 |
Fathollahi, Y; Hosseinmardi, N; Mirnajafi-Zadeh, J; Shahabi, P | 1 |
Chai, KY; Chen, J; Lee, JS; Quan, ZS; Song, MS; Sun, XY | 1 |
Franklin, MR; Kupferberg, HJ; Schmutz, M; Stables, JP; White, HS; Wolf, HH | 1 |
Caliş, U; Demirdamar, R; Erol, DD; Ertan, M; Yuluğ, N | 1 |
Ekinci, AC; Ergenç, N; Ulusoy, N | 1 |
Bazan, NG; Marcheselli, VL | 1 |
Dalton, CR; Dudley, MW; Kane, JM; Kehne, JH; Ketteler, HJ; McCloskey, TC; Miller, FP; Ogden, AM; Senyah, Y; Staeger, MA | 1 |
Modica, M; Russo, F; Santagati, A; Santagati, M; Spampinato, S | 1 |
Cross, AJ; Green, AR; Misra, A; Murray, TK; Snape, MF | 1 |
Chaney, SF; Hurst, G; Kane, JM; Kehne, JH; McCloskey, TC; Petty, MA; Senyah, Y; White, HS; Wolf, HH; Zobrist, R | 1 |
Caccia, S; Cagnotto, A; Fracasso, C; Ghia, M; Grossi, G; Mennini, T; Nacca, A; Roma, G | 1 |
Ebinger, G; Khan, GM; Michotte, Y; Smolders, I | 1 |
Canger, R; Henriksen, O; Karolchyk, MA; Pålhagen, S; Rivière, ME; van Parys, JA | 1 |
Bailey, L; Dunner, DL; Laird, LK; Seabolt, JL; Sussman, N; Zajecka, J | 1 |
Chidester, C; Duchamp, DJ; Gall, M; Lahti, RA; Rudzik, AD; Scahill, T | 1 |
Kamdar, BV; Moffett, RB; Von Voigtlander, PF | 1 |
Abdallah, A; Braun, DL; Chaney, SF; Dudley, MW; Kane, JM; Kehne, JH; Ketteler, HJ; Miller, FP; Ogden, AM; Senyah, Y | 1 |
Junnarkar, AY; Patnaik, GK; Shrotri, DS; Singh, PP | 1 |
Ashton, D; Clincke, GH; Fransen, J; Heeres, J; Janssen, PA | 1 |
Bastide, J; Bastide, P; Coudert, P; Couquelet, JM; Rubat, C; Tronche, P | 1 |
Kadaba, PK | 1 |
Egilmez, S; Itil, TM; Marasa, J; Polvan, N; Saletu, B | 1 |
Achari, G; Ahmad, A; Vohra, MM | 1 |
Bennett, JW; Ma, OH; Orth, RE; Young, L | 1 |
9 review(s) available for triazoles and Seizures
Article | Year |
---|---|
An Important Potential Anti-Epileptic/Anticonvulsant Active Group: A Review of 1,2,4-Triazole Groups and Their Action.
Topics: Anticonvulsants; Epilepsy; Humans; Seizures; Triazoles | 2022 |
Efficacy and safety of rufinamide as adjunctive therapy in patients with Lennox Gastaut syndrome: A systematic review and Meta-analysis.
Topics: Anticonvulsants; Humans; Lennox Gastaut Syndrome; Randomized Controlled Trials as Topic; Seizures; Triazoles | 2021 |
Exploring the Chemistry and Therapeutic Potential of Triazoles: A Comprehensive Literature Review.
Topics: Humans; Infections; Inflammation; Neoplasms; Neurodegenerative Diseases; Oxidative Stress; Seizures; Triazoles | 2019 |
3,4-DHQLO and Triazole and Its Related Analogues with Anticonvulsant Effects.
Topics: Animals; Anticonvulsants; Drug Design; Epilepsy; Humans; Hydroquinones; Seizures; Structure-Activity Relationship; Triazoles | 2016 |
1,2,4-triazole derivatives as potential scaffold for anticonvulsant activity.
Topics: Animals; Anticonvulsants; Epilepsy; Humans; Seizures; Structure-Activity Relationship; Triazoles | 2015 |
Rufinamide: a new antiepileptic medication for the treatment of seizures associated with lennox-gastaut syndrome.
Topics: Aged; Anticonvulsants; Chemistry, Pharmaceutical; Child; Clinical Trials, Phase III as Topic; Counseling; Drug Resistance; Epilepsies, Partial; Epilepsy; Humans; Off-Label Use; Randomized Controlled Trials as Topic; Seizures; Syndrome; Triazoles | 2010 |
Rufinamide from clinical trials to clinical practice in the United States and Europe.
Topics: Anticonvulsants; Child; Child, Preschool; Europe; Humans; Intellectual Disability; Lennox Gastaut Syndrome; Randomized Controlled Trials as Topic; Seizures; Spasms, Infantile; Treatment Outcome; Triazoles; United States | 2011 |
Rufinamide.
Topics: Animals; Anticonvulsants; Clinical Trials as Topic; Humans; Seizures; Triazoles | 2006 |
Six-year perspectives on the safety and tolerability of nefazodone.
Topics: Age Factors; Antidepressive Agents, Second-Generation; Body Weight; Chronic Disease; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; Male; Obesity; Piperazines; Priapism; Seizures; Sexual Dysfunctions, Psychological; Suicide; Triazoles | 2002 |
3 trial(s) available for triazoles and Seizures
Article | Year |
---|---|
Real-world data on rufinamide treatment in patients with Lennox-Gastaut syndrome: Results from a European noninterventional registry study.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Ethnicity; Europe; European Union; Female; Humans; Lennox Gastaut Syndrome; Male; Registries; Seizures; Sleep Stages; Treatment Outcome; Triazoles | 2017 |
A randomized, double-blind, placebo-controlled, parallel-group study of rufinamide as adjunctive therapy for refractory partial-onset seizures.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Double-Blind Method; Drug Resistance; Epilepsies, Partial; Humans; Middle Aged; Sample Size; Seizures; Triazoles; Young Adult | 2011 |
Rufinamide: a double-blind, placebo-controlled proof of principle trial in patients with epilepsy.
Topics: Adult; Anticonvulsants; Double-Blind Method; Drug Therapy, Combination; Epilepsy; Female; Half-Life; Humans; Incidence; Male; Middle Aged; Nervous System Diseases; Seizures; Triazoles | 2001 |
103 other study(ies) available for triazoles and Seizures
Article | Year |
---|---|
Discovery of 7-alkyloxy- [1,2,4] triazolo[1,5-a] pyrimidine derivatives as selective positive modulators of GABA
Topics: Animals; Anticonvulsants; Cells, Cultured; Dose-Response Relationship, Drug; Drug Discovery; Electroshock; Epilepsy; Male; Mice; Mice, Inbred Strains; Molecular Structure; Neurons; Pentylenetetrazole; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Structure-Activity Relationship; Triazoles | 2022 |
Therapeutic Drug Monitoring for Rufinamide in Japanese Patients With Epilepsy: Focus on Drug Interactions, Tolerability, and Clinical Effectiveness.
Topics: Anticonvulsants; Drug Interactions; Drug Monitoring; Epilepsy; Humans; Japan; Retrospective Studies; Seizures; Treatment Outcome; Triazoles | 2022 |
Design, synthesis, molecular docking and pharmacological evaluation of novel triazine-based triazole derivatives as potential anticonvulsant agents.
Topics: Anticonvulsants; Electroshock; Humans; Molecular Docking Simulation; Molecular Structure; Pentylenetetrazole; Seizures; Structure-Activity Relationship; Triazines; Triazoles | 2022 |
A single-center SCN8A-related epilepsy cohort: clinical, genetic, and physiologic characterization.
Topics: Cell Culture Techniques; Child; Cohort Studies; Epilepsy; Female; HEK293 Cells; Humans; Infant; Infant, Newborn; Male; Mutation; NAV1.6 Voltage-Gated Sodium Channel; Oxcarbazepine; Pyridines; Seizures; Sodium Channels; Triazoles | 2019 |
Rufinamide efficacy and association with phenotype and genotype in children with intractable epilepsy: A retrospective single center study.
Topics: Anticonvulsants; Child; Child, Preschool; Drug Resistant Epilepsy; Epilepsy; Female; Genotype; Humans; Infant; Lennox Gastaut Syndrome; Male; Phenotype; Retrospective Studies; Seizures; Triazoles | 2020 |
Caffeine Exacerbates Postictal Hypoxia.
Topics: Adenosine; Animals; CA1 Region, Hippocampal; Caffeine; Dose-Response Relationship, Drug; Hypoxia; Kindling, Neurologic; Male; Oxygen; Phenethylamines; Pyrimidines; Rats; Receptors, Adenosine A2; Seizures; Triazoles | 2019 |
Design, Synthesis and Biological Activity of Some 4, 5-Disubstituted-2, 4- Dihydro-3H-1, 2, 4- Triazole-3-Thione Derivatives.
Topics: Animals; Anticonvulsants; Drug Design; Male; Mice; Seizures; Thiones; Triazoles | 2019 |
Screening of Some Novel 4, 5 Disubstituted 1, 2, 4-Triazole-3-thiones for Anticonvulsant Activity.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Ataxia; Convulsants; Drug Evaluation, Preclinical; Electroshock; Male; Mice; Molecular Docking Simulation; Pentylenetetrazole; Rotarod Performance Test; Seizures; Structure-Activity Relationship; Triazoles | 2020 |
Anticonvulsant and neurotoxic effects of a novel 1,2,4-triazole-3-thione derivative (TPF-34) and its isobolographic interaction profile with classical antiepileptic drugs in mice.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Male; Mice; Seizures; Time Factors; Tissue Distribution; Triazoles | 2020 |
Rufinamide as add-on therapy in children with epileptic encephalopathies other than Lennox-Gastaut syndrome: A study of 34 patients.
Topics: Adolescent; Anticonvulsants; Argentina; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; Follow-Up Studies; Humans; Lennox Gastaut Syndrome; Male; Retrospective Studies; Seizures; Triazoles; Valproic Acid | 2020 |
Anticonvulsant Effectiveness and Neurotoxicity Profile of 4-butyl-5-[(4-chloro-2-methylphenoxy)methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione (TPL-16) in Mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Synergism; Male; Mice; Muscle Strength; Phenobarbital; Phenytoin; Rotarod Performance Test; Seizures; Thiones; Triazoles; Valproic Acid | 2021 |
Synthesis of Novel Triazolyl/Oxadiazolyl/Thiadiazolyl-Piperazine as Potential Anticonvulsant Agents.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Female; Humans; Male; Mice; Oxadiazoles; Piperazine; Rats; Seizures; Structure-Activity Relationship; Thiadiazoles; Toxicity Tests, Acute; Triazoles | 2021 |
How Can an Na
Topics: Animals; Female; Lennox Gastaut Syndrome; Male; Mice; Mice, Inbred C57BL; Neurons; Seizures; Triazoles; Voltage-Gated Sodium Channel Blockers | 2021 |
Effect of Chronic Administration of 5-(3-chlorophenyl)-4-Hexyl-2,4 -Dihydro-3
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Cytochrome P-450 Enzyme System; Electroshock; Kidney; Liver; Male; Mice; Neurodegenerative Diseases; Permeability; Protein Isoforms; Seizures; Triazoles | 2021 |
Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome.
Topics: Action Potentials; Animals; Epilepsies, Myoclonic; Ion Channel Gating; Mice, Inbred C57BL; Mice, Knockout; NAV1.1 Voltage-Gated Sodium Channel; NAV1.6 Voltage-Gated Sodium Channel; Neurons; Pyramidal Cells; Pyridines; Seizures; Survival Analysis; Triazoles | 2017 |
Molecular mechanism of action and safety of 5-(3-chlorophenyl)-4-hexyl-2,4-dihydro-3
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Hep G2 Cells; Humans; Mice; Patch-Clamp Techniques; Seizures; Thiones; Triazoles; Voltage-Gated Sodium Channels | 2017 |
Design, synthesis, in vivo and in silico evaluation of phenacyl triazole hydrazones as new anticonvulsant agents.
Topics: Animals; Anticonvulsants; Biological Availability; Drug Design; Hydrazones; Injections, Intraperitoneal; Male; Mice; Molecular Docking Simulation; Molecular Structure; Motor Activity; Pentylenetetrazole; Seizures; Triazoles | 2018 |
Neuropharmacological and molecular docking studies of xanthones from Swertia corymbosa.
Topics: Animals; Anticonvulsants; Anxiety; Electroshock; Epilepsy; Isoniazid; Male; Maze Learning; Mice; Molecular Docking Simulation; Motor Activity; Neuropharmacology; Rotarod Performance Test; Seizures; Serotonin; Swertia; Triazoles; Xanthones | 2018 |
Neuromuscular anomalies following oral exposure to 3-nitro-1,2,4-triazol-5-one (NTO) in a one-generation study with Japanese quail (Coturnix japonica).
Topics: Administration, Oral; Animals; Coturnix; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Explosive Agents; Female; Male; Nitro Compounds; Reproduction; Seizures; Toxicity Tests, Acute; Triazoles | 2018 |
Three children with Lennox-Gastaut syndrome presenting long-term good seizure outcome under rufinamide treatment.
Topics: Anticonvulsants; Child; Child, Preschool; Female; Humans; Infant; Lennox Gastaut Syndrome; Male; Seizures; Time Factors; Treatment Outcome; Triazoles | 2017 |
Synthesis and anticonvulsant screening of 1,2,4-triazole derivatives.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroshock; Male; Mice; Rats; Rats, Sprague-Dawley; Seizures; Triazoles; X-Ray Diffraction | 2018 |
Development of the 1,2,4-triazole-based anticonvulsant drug candidates acting on the voltage-gated sodium channels. Insights from in-vivo, in-vitro, and in-silico studies.
Topics: Animals; Anticonvulsants; Cell Line; Cell Line, Tumor; Cell Membrane Permeability; Computer Simulation; Electroshock; HEK293 Cells; Hep G2 Cells; Humans; Mice; Molecular Docking Simulation; Receptors, GABA-A; Seizures; Triazoles; Voltage-Gated Sodium Channels | 2019 |
Novel fused 1,2,3-triazolo-benzodiazepine derivatives as potent anticonvulsant agents: design, synthesis, in vivo, and in silico evaluations.
Topics: Anticonvulsants; Benzodiazepines; Binding Sites; Chemistry Techniques, Synthetic; Drug Design; GABA-A Receptor Antagonists; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Protein Binding; Quantitative Structure-Activity Relationship; Receptors, GABA-A; Seizures; Triazoles | 2020 |
Synthesis and evaluation of the anticonvulsant activity of 8-alkoxy-4,5-dihydrobenzo[b][1,2,4]triazolo[4,3-d][1,4]thiazepine derivatives.
Topics: Animals; Anticonvulsants; Computational Biology; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Mice; Molecular Structure; Rotarod Performance Test; Seizures; Thiazepines; Triazoles | 2014 |
Synthesis and anticonvulsant activity evaluation of 4-(2-alkoxy-phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-ones in various experimental seizure models in mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Mice; Seizures; Triazoles | 2013 |
Design, synthesis and anticonvulsant activity evaluation of novel 4-(4-substitutedphenyl)-3-methyl-1H-1,2,4-triazol-5(4H)-ones.
Topics: Animals; Anticonvulsants; Carbamazepine; Convulsants; Drug Design; Drug Evaluation, Preclinical; Electroshock; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mice; Pentylenetetrazole; Postural Balance; Seizures; Structure-Activity Relationship; Triazoles | 2014 |
Design, synthesis and evaluation of the antidepressant and anticonvulsant activities of triazole-containing quinolinones.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Electroshock; Exploratory Behavior; Male; Mice; Mice, Inbred Strains; Molecular Structure; Quinolones; Rotarod Performance Test; Seizures; Swimming; Triazoles | 2014 |
Synthesis, receptor affinity and effect on pentylenetetrazole-induced seizure threshold of novel benzodiazepine analogues: 3-Substituted 5-(2-phenoxybenzyl)-4H-1,2,4-triazoles and 2-amino-5-(phenoxybenzyl)-1,3,4-oxadiazoles.
Topics: Animals; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Structure; Oxadiazoles; Pentylenetetrazole; Receptors, GABA-A; Seizures; Structure-Activity Relationship; Triazoles | 2014 |
Synthesis of some novel 1,2,4-triazol-3-one derivatives bearing the salicyl moiety and their anticonvulsant activities.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Design; Electroshock; Mice; Molecular Structure; Salicylates; Seizures; Structure-Activity Relationship; Time Factors; Triazoles | 2014 |
Antiepileptic activity of preferential inhibitors of persistent sodium current.
Topics: Acetanilides; Animals; Anticonvulsants; Cells, Cultured; Female; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; NAV1.2 Voltage-Gated Sodium Channel; Neurons; Piperazines; Pyridines; Ranolazine; Seizures; Sodium Channel Blockers; Triazoles | 2014 |
Successful Treatment of Refractory Seizures With Rufinamide in Children With Schizencephaly: Report of 3 Cases.
Topics: Anticonvulsants; Child; Electroencephalography; Humans; Magnetic Resonance Imaging; Male; Schizencephaly; Seizures; Triazoles | 2015 |
Studies on the anticonvulsant activity and influence on GABA-ergic neurotransmission of 1,2,4-triazole-3-thione- based compounds.
Topics: Animals; Anticonvulsants; Disease Models, Animal; GABA Agents; Male; Mice; Seizures; Synaptic Transmission; Toxicity Tests; Triazoles | 2014 |
Studies on the anticonvulsant activity of 4-alkyl-1,2,4-triazole-3-thiones and their effect on GABAergic system.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Male; Mice; Molecular Structure; Receptors, GABA-A; Seizures; Structure-Activity Relationship; Triazoles | 2014 |
Synthesis and Anticonvulsant Activity Evaluation of 4-Phenyl-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one and Its Derivatives.
Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Brain; Disease Models, Animal; Drug Design; Electroshock; Mice; Molecular Structure; Motor Activity; Pentylenetetrazole; Quinazolinones; Rotarod Performance Test; Seizures; Structure-Activity Relationship; Time Factors; Triazoles | 2015 |
BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice.
Topics: Animals; Azepines; Blotting, Western; Cells, Cultured; Chromatin Immunoprecipitation; Female; Immunohistochemistry; Male; Memory; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Neurons; Nuclear Proteins; Polymerase Chain Reaction; RNA, Small Interfering; Seizures; Transcription Factors; Transcriptional Activation; Transfection; Triazoles | 2015 |
Synthesis and Some Reactions of 1-aryl-4-acetyl-5-methyl-1,2,3-triazole Derivatives with Anticonvulsant Activity.
Topics: Animals; Anticonvulsants; Azepines; Chalcones; Chemistry Techniques, Synthetic; Male; Methylation; Mice; Seizures; Sonication; Structure-Activity Relationship; Triazoles | 2016 |
Aggravation of atonic seizures by rufinamide: A case report.
Topics: Anticonvulsants; Benzodiazepines; Brain; Child; Clobazam; Drug Resistant Epilepsy; Drug Therapy, Combination; Electroencephalography; Humans; Levetiracetam; Male; Piracetam; Seizures; Triazoles; Valproic Acid | 2016 |
Rufinamide in children and adults in routine clinical practice.
Topics: Adolescent; Adult; Anticonvulsants; Child; Epilepsy, Generalized; Female; Humans; Lennox Gastaut Syndrome; Male; Middle Aged; Seizures; Triazoles; Vomiting; Weight Loss | 2017 |
Preliminary Pharmacological Screening of Some Thiosemicarbazide, s-triazole, and Thiadiazole Derivatives.
Topics: Analgesics; Animals; Anxiety; Body Temperature; Central Nervous System Agents; Depression; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Mice; Molecular Structure; Motor Activity; Nociceptive Pain; Seizures; Semicarbazides; Sleep; Thiadiazoles; Triazoles | 2016 |
Alcohol-induced retrograde memory impairment in rats: prevention by caffeine.
Topics: Adenosine A2 Receptor Antagonists; Amnesia, Retrograde; Animals; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ethanol; Exploratory Behavior; Habituation, Psychophysiologic; Injections, Intraperitoneal; Male; Odorants; Pentylenetetrazole; Phosphodiesterase 5 Inhibitors; Purinones; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Recognition, Psychology; Seizures; Smell; Time Factors; Triazines; Triazoles; Wood | 2008 |
Alternaria infectoria brain abscess in a child with chronic granulomatous disease.
Topics: Alternaria; Antifungal Agents; Brain; Brain Abscess; Caspofungin; Child, Preschool; Echinocandins; Fatal Outcome; Granulomatous Disease, Chronic; Humans; Lipopeptides; Male; Mycoses; Pyrimidines; Radiography; RNA, Fungal; RNA, Ribosomal, 5.8S; Seizures; Triazoles; Voriconazole | 2009 |
The role of adenosine A(1) receptors in mediating the inhibitory effects of low frequency stimulation of perforant path on kindling acquisition in rats.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Biophysics; Cyclic AMP; Electric Stimulation; Excitatory Postsynaptic Potentials; Hippocampus; Kindling, Neurologic; Male; Neural Inhibition; Perforant Pathway; Rats; Rats, Wistar; Receptor, Adenosine A1; Seizures; Time Factors; Triazines; Triazoles; Xanthines | 2009 |
Effectiveness and tolerability of rufinamide in children and adults with refractory epilepsy: first European experience.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Resistance; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Europe; Female; Humans; Infant; Male; Middle Aged; Orphan Drug Production; Retrospective Studies; Seizures; Treatment Outcome; Triazoles; Young Adult | 2009 |
Evaluation of anticonvulsant activity of QUAN-0806 in various murine experimental seizure models.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Convulsants; Electroshock; Enzyme Activation; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Postural Balance; Quinolines; Seizures; Synaptic Transmission; Triazoles | 2009 |
Isolated cerebral aspergilloma in a young immunocompetent patient.
Topics: Adult; Amphotericin B; Antifungal Agents; Aspergillosis; Brain Edema; Female; Humans; Muscle Weakness; Pyrimidines; Seizures; Treatment Outcome; Triazoles; Voriconazole | 2009 |
Rufinamide: Further evaluation is needed in Lennox-Gastaut syndrome.
Topics: Adult; Child; Clinical Trials as Topic; Drug Approval; Epilepsy; Europe; Humans; Orphan Drug Production; Seizures; Triazoles | 2008 |
The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment of cognitive dysfunction.
Topics: Animals; Anticonvulsants; Benzodiazepines; Cell Line; Cognition Disorders; Disease Models, Animal; Drug Discovery; Drug Inverse Agonism; GABA-A Receptor Agonists; Humans; Imidazoles; Mice; Protein Binding; Rats; Receptors, GABA-A; Seizures; Structure-Activity Relationship; Triazoles | 2009 |
Caffeine and an adenosine A(2A) receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life.
Topics: Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Animals, Newborn; Caffeine; Disease Models, Animal; Disease Progression; Drug Administration Schedule; Glial Fibrillary Acidic Protein; Kainic Acid; Memory Disorders; Neurotoxicity Syndromes; Phosphodiesterase Inhibitors; Purines; Pyrimidines; Qa-SNARE Proteins; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Synapses; Synaptophysin; Synaptosomal-Associated Protein 25; Triazoles; Tritium; Xanthines | 2010 |
Supporting the recommended paediatric dosing regimen for rufinamide in Lennox-Gastaut syndrome using clinical trial simulation.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Computer Simulation; Drug Dosage Calculations; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Models, Statistical; Nonlinear Dynamics; Seizures; Syndrome; Triazoles | 2010 |
Synthesis and anticonvulsant activity of a new 6-alkoxy-[1,2,4]triazolo[4,3-b]pyridazine.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Mice; Molecular Structure; Motor Activity; Pyridazines; Rotarod Performance Test; Seizures; Stereoisomerism; Structure-Activity Relationship; Triazoles | 2010 |
Experience with rufinamide in a pediatric population: a single center's experience.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Pediatrics; Retrospective Studies; Seizures; Treatment Outcome; Triazoles; Young Adult | 2010 |
Synthesis and anticonvulsant activity of 7-alkoxy-triazolo-[3, 4-b]benzo[d]thiazoles.
Topics: Animals; Anticonvulsants; Benzothiazoles; Carbamazepine; Drug Evaluation, Preclinical; Electroshock; Mice; Motor Activity; Phenytoin; Seizures; Structure-Activity Relationship; Triazoles | 2010 |
Anticonvulsant activity and toxicity evaluation of Cu(II) and Zn(II) metal complexes derived from triazole-quinoline ligands.
Topics: Animals; Anticonvulsants; Coordination Complexes; Copper; Ligands; Quinolines; Rats; Rats, Wistar; Seizures; Triazoles; Zinc | 2010 |
Serum concentrations of rufinamide in children and adults with epilepsy: the influence of dose, age, and comedication.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Body Weight; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Intellectual Disability; Lennox Gastaut Syndrome; Male; Middle Aged; Seizures; Spasms, Infantile; Triazoles; Valproic Acid; Young Adult | 2011 |
Synthesis and anticonvulsant activity of 7-phenyl-6,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones and their derivatives.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Electroshock; Isoniazid; Mice; Pentylenetetrazole; Pyrimidinones; Seizures; Semicarbazides; Structure-Activity Relationship; Triazoles | 2011 |
Selective blockade of A(2A) receptor protects against neurotoxicity induced by kainic acid in young rats.
Topics: Adenosine A2 Receptor Antagonists; Animals; Brain; Catalase; Glutathione Peroxidase; Glutathione Transferase; Kainic Acid; Male; Neurotoxicity Syndromes; Oxidative Stress; Pyrimidines; Rats; Reactive Oxygen Species; Seizures; Triazoles | 2012 |
[Sedative, hypnotic and anticonvulsive effects of an adenosine analogue WS090501].
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Anticonvulsants; Convulsants; Electroencephalography; Hypnotics and Sedatives; Male; Mice; Mice, Inbred ICR; Motor Activity; Pentylenetetrazole; Pyrimidines; Rats; Rats, Wistar; Seizures; Sleep; Triazoles; Xanthines | 2011 |
Synthesis and biological evaluation of 9-alkoxy-6,7-dihydro-5H-benzo[c] [1,2,4]triazolo[4,3-a]azepines as potential anticonvulsant agents.
Topics: Animals; Anticonvulsants; Azepines; Convulsants; Electroshock; Mice; Pentylenetetrazole; Postural Balance; Seizures; Spectrophotometry, Infrared; Structure-Activity Relationship; Triazoles | 2012 |
Effect of adenosine A2A receptor antagonist ZM241385 on amygdala-kindled seizures and progression of amygdala kindling.
Topics: Adenosine A2 Receptor Antagonists; Amygdala; Animals; Dose-Response Relationship, Drug; Male; Rats; Rats, Wistar; Receptor, Adenosine A2A; Seizures; Treatment Outcome; Triazines; Triazoles | 2012 |
Synthesis and anticonvulsant activities of some triazolothiadiazole derivatives.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Injections, Intraperitoneal; Mice; Mice, Inbred Strains; Molecular Structure; Seizures; Thiadiazoles; Triazoles | 2012 |
Craniocerebral maduromycosis.
Topics: Adolescent; Antifungal Agents; Bone Diseases; Brain Diseases; Female; Humans; India; Madurella; Magnetic Resonance Imaging; Mycetoma; Naphthalenes; Parietal Lobe; Pyrimidines; Scalp; Seizures; Terbinafine; Tomography, X-Ray Computed; Triazoles; Voriconazole | 2012 |
Effect of 4-(4-bromophenyl)-5-(3-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione on the anticonvulsant action of different classical antiepileptic drugs in the mouse maximal electroshock-induced seizure model.
Topics: Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Brain; Disease Models, Animal; Drug Interactions; Electroshock; Hand Strength; Male; Memory; Mice; Motor Activity; Muscle, Skeletal; Seizures; Thiones; Triazoles | 2012 |
Relapsing cerebral aspergilloma associated with pregnancy.
Topics: Adult; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Brain; Central Nervous System Fungal Infections; Female; Humans; Infant, Newborn; Magnetic Resonance Imaging; Pregnancy; Pregnancy Complications, Infectious; Pyrimidines; Recurrence; Seizures; Triazoles; Voriconazole | 2013 |
Rufinamide for refractory focal seizures: an open-label, multicenter European study.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Europe; Female; Humans; Longitudinal Studies; Male; Middle Aged; Seizures; Treatment Outcome; Triazoles; Young Adult | 2013 |
Effectiveness and tolerability of rufinamide in children and young adults with Lennox-Gastaut syndrome: a single center study in Korea.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Female; Humans; Intellectual Disability; Lennox Gastaut Syndrome; Male; Neurosurgical Procedures; Republic of Korea; Retrospective Studies; Seizures; Spasms, Infantile; Treatment Outcome; Triazoles; Young Adult | 2013 |
Design, synthesis, and anticonvulsant activity evaluation of 4-(3-alkoxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-ones.
Topics: Animals; Anticonvulsants; Drug Design; Electroshock; Mice; Mice, Inbred Strains; Molecular Structure; Neurotoxicity Syndromes; Seizures; Triazoles | 2013 |
Synthesis and anticonvulsant activity evaluation of 5-phenyl-[1,2,4]triazolo[4,3-c]quinazolin-3-amines.
Topics: Amines; Animals; Anticonvulsants; Drug Design; Electroshock; Mice; Mice, Inbred Strains; Molecular Structure; Neurotoxicity Syndromes; Quinazolines; Rotarod Performance Test; Seizures; Triazoles | 2013 |
Synthesis, characterization and preliminary anticonvulsant evaluation of some 4-alkyl-1,2,4-triazoles.
Topics: Animals; Anticonvulsants; Electroshock; Male; Mice; Molecular Structure; Seizures; Triazoles | 2013 |
Broad spectrum anticonvulsant activity of BW534U87: possible role of an adenosine-dependent mechanism.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Amygdala; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Electroshock; Enzyme Inhibitors; Female; Kindling, Neurologic; Male; Mice; Pentylenetetrazole; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Seizures; Triazoles; Xanthines | 2002 |
Design and synthesis of 4H-3-(2-phenoxy)phenyl-1,2,4-triazole derivatives as benzodiazepine receptor agonists.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Drug Design; GABA-A Receptor Agonists; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mice; Models, Molecular; Molecular Conformation; Pentylenetetrazole; Postural Balance; Seizures; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Triazoles | 2003 |
[Insulin shock, electro-, tetrazole, triazole convulsions and the peripheral vascular system].
Topics: Cardiovascular Diseases; Cardiovascular System; Convulsive Therapy; Insulin Coma; Seizures; Sympathomimetics; Tetrazoles; Triazoles | 1957 |
THE ANTICONVULSANT ACTIVITY OF 1,2,4-TRIAZOLES.
Topics: Anticonvulsants; Central Nervous System Stimulants; Pharmacology; Rats; Research; Seizures; Triazoles | 1962 |
Seroquel, Serzone and seizures.
Topics: Adult; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Dibenzothiazepines; Drug Packaging; Female; Humans; Medication Errors; Piperazines; Quetiapine Fumarate; Seizures; Triazoles | 2004 |
Interaction of loreclezole with conventional antiepileptic drugs in amygdala-kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Avoidance Learning; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Kindling, Neurologic; Male; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Seizures; Triazoles | 2004 |
Endogenous adenosine modulates epileptiform activity in rat hippocampus in a receptor subtype-dependent manner.
Topics: Adenosine; Animals; Animals, Newborn; Dihydropyridines; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Indoles; Maleimides; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Seizures; Theophylline; Time Factors; Triazines; Triazoles | 2004 |
Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3alpha-androstanediol and 17beta-estradiol.
Topics: Androstane-3,17-diol; Animals; Aromatase Inhibitors; Chromatography; Convulsants; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estradiol; Finasteride; Hippocampus; Letrozole; Male; Mass Spectrometry; Mice; Nitriles; Organ Culture Techniques; Patch-Clamp Techniques; Pentylenetetrazole; Rats; Receptors, GABA-A; Seizures; Testosterone; Triazoles | 2004 |
Pharmacodynamic and pharmacokinetic interaction studies of loreclezole with felbamate, lamotrigine, topiramate, and oxcarbazepine in the mouse maximal electroshock seizure model.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Electroshock; Felbamate; Fructose; Kindling, Neurologic; Lamotrigine; Male; Mice; Motor Activity; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Seizures; Topiramate; Triazines; Triazoles | 2005 |
Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis.
Topics: Animals; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Ethosuximide; Kindling, Neurologic; Linear Models; Male; Mice; Pentylenetetrazole; Phenobarbital; Seizures; Triazoles; Valproic Acid | 2005 |
Adenosine A1 and A2A receptors of hippocampal CA1 region have opposite effects on piriform cortex kindled seizures in rats.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Cerebral Cortex; Electric Stimulation; Hippocampus; Kindling, Neurologic; Male; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptors, Purinergic P2; Seizures; Triazines; Triazoles; Xanthines | 2006 |
Isobolographic analysis of interactions between loreclezole and conventional antiepileptic drugs in the mouse maximal electroshock-induced seizure model.
Topics: Algorithms; Animals; Anticonvulsants; Avoidance Learning; Brain; Drug Interactions; Dyskinesia, Drug-Induced; Electroshock; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Male; Memory; Mice; Psychomotor Performance; Seizures; Triazoles | 2006 |
Antibacterial, antifungal and anticonvulsant evaluation of novel newly synthesized 1-[2-(1H-tetrazol-5-yl)ethyl]-1H-benzo[d][1, 2,3]triazoles.
Topics: Animals; Anti-Bacterial Agents; Anticonvulsants; Antifungal Agents; Bacillus subtilis; Candida albicans; Electroshock; Mice; Microbial Sensitivity Tests; Seizures; Triazoles | 2006 |
The role of adenosine A1 and A2A receptors of entorhinal cortex on piriform cortex kindled seizures in rats.
Topics: Adenosine; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Entorhinal Cortex; Kindling, Neurologic; Male; Microinjections; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Seizures; Triazines; Triazoles; Xanthines | 2007 |
Synthesis and anticonvulsant evaluation of 4-(4-alkoxylphenyl)-3-ethyl-4H-1,2,4-triazoles as open-chain analogues of 7-alkoxyl-4,5-dihydro[1,2,4]triazolo[4,3-a]quinolines.
Topics: Animals; Anticonvulsants; Mice; Mice, Inbred C57BL; Quinolines; Seizures; Strychnine; Triazoles | 2007 |
The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Injections, Intraperitoneal; Mice; Phenobarbital; Phenytoin; Rats; Rats, Sprague-Dawley; Seizures; Severity of Illness Index; Triazoles; Valproic Acid | 2008 |
Synthesis and biological activities of some 3,6-disubstituted thiazolo[3,2-b][1,2,4]triazoles.
Topics: Animals; Anticonvulsants; Antifungal Agents; Candida; Electroshock; Male; Mice; Microbial Sensitivity Tests; Pentylenetetrazole; Seizures; Spectrophotometry, Infrared; Thiazoles; Triazoles | 1995 |
Synthesis and anticonvulsant activity of some new 1,1-bis(4-substituted 1,2,4-triazoline-5-thione-3-yl)-2-methylbutanes.
Topics: Animals; Anticonvulsants; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Pentylenetetrazole; Seizures; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Thiones; Triazoles | 1995 |
Platelet-activating factor is a messenger in the electroconvulsive shock-induced transcriptional activation of c-fos and zif-268 in hippocampus.
Topics: Animals; Azepines; Base Sequence; DNA-Binding Proteins; Early Growth Response Protein 1; Electroshock; Gene Expression Regulation; Hippocampus; Immediate-Early Proteins; Male; Microsomes; Molecular Sequence Data; Neuronal Plasticity; Platelet Activating Factor; Platelet Membrane Glycoproteins; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Seizures; Synaptic Membranes; Tetrazoles; Thienopyridines; Transcription Factors; Transcription, Genetic; Triazoles; Zinc Fingers | 1994 |
5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents.
Topics: Animals; Anticonvulsants; Cerebellum; Cerebral Cortex; Chlorides; Electroshock; Flumazenil; Male; Mice; Molecular Structure; Muscle Spasticity; Paralysis; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship; Strychnine; Triazoles | 1994 |
Synthesis of aminothienopyrimidine and thienotriazolopyrimidine derivatives as potential anticonvulsant agents.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry, Physical; Male; Mice; Motor Activity; Pyrimidines; Rats; Seizures; Thiophenes; Triazoles | 1996 |
A behavioural and neurochemical study in rats of the pharmacology of loreclezole, a novel allosteric modulator of the GABAA receptor.
Topics: Allosteric Regulation; Animals; Behavior, Animal; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlormethiazole; Dose-Response Relationship, Drug; GABA Modulators; Hypnotics and Sedatives; Male; Muscle Relaxation; Pentobarbital; Picrotoxin; Rats; Receptors, GABA-A; Seizures; Sesterterpenes; Triazoles | 1996 |
Preclinical characterization of MDL 27,192 as a potential broad spectrum anticonvulsant agent with neuroprotective properties.
Topics: Animals; Anticonvulsants; Cerebral Infarction; Craniocerebral Trauma; Electroshock; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Kindling, Neurologic; Male; Mice; Mice, Inbred DBA; Motor Activity; Neuroprotective Agents; Rats; Rats, Inbred F344; Rats, Inbred SHR; Rats, Sprague-Dawley; Seizures; Triazoles; Valproic Acid | 1997 |
Acid-catalysed hydrolysis and benzodiazepine-like properties of 5-(dialkylamino)- and 5-(alkylthio)-substituted 8-chloro-6-phenyl-6H-[1,2,4]triazolol[4,3-a][1,5]benzodiazepines in mice.
Topics: Administration, Oral; Animals; Anticonvulsants; Benzodiazepines; Brain; Gastric Acid; Hydrolysis; Male; Mice; Pentylenetetrazole; Receptors, GABA-A; Seizures; Triazoles | 1998 |
Anticonvulsant effect and neurotransmitter modulation of focal and systemic 2-chloroadenosine against the development of pilocarpine-induced seizures.
Topics: 2-Chloroadenosine; Animals; Anticonvulsants; Behavior, Animal; Electroencephalography; Electrophysiology; Hippocampus; Injections; Male; Muscarinic Agonists; Neurotransmitter Agents; Pilocarpine; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Wistar; Seizures; Triazoles | 2000 |
Novel anxiolytic agents derived from alpha-amino-alpha-phenyl-o-tolyl-4H-triazoles and -imidazoles.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Brain; Crystallography; Hypnotics and Sedatives; Imidazoles; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Models, Molecular; Molecular Conformation; Muscle Relaxation; Nicotine; Pentylenetetrazole; Rats; Seizures; Semicarbazides; Triazoles | 1978 |
Central nervous system depressants. 13. s-Triazolo-1,5-benzodiazepin-5-ones.
Topics: Animals; Benzodiazepinones; Central Nervous System; Depression, Chemical; Male; Mice; Nicotine; Pentylenetetrazole; Reflex; Seizures; Strychnine; Triazoles | 1976 |
MDL 27,531 selectively reverses strychnine-induced seizures in mice.
Topics: Administration, Oral; Animals; Electric Stimulation; Hypnotics and Sedatives; Injections, Intraperitoneal; Male; Mice; Receptors, Glycine; Receptors, Neurotransmitter; Seizures; Strychnine; Triazoles | 1992 |
Neuropsychopharmacological study of 2,4-dihydro[1,2,4]triazolo[3,4-c][1,4]benzothiazine-1-one (IDPH-791).
Topics: Administration, Oral; Animals; Brain; Hypnosis; Injections, Intraperitoneal; Lethal Dose 50; Mephenesin; Mice; Motor Activity; Muscle Relaxants, Central; Muscle Relaxation; Paralysis; Rabbits; Rats; Rats, Wistar; Seizures; Thiazines; Triazoles | 1992 |
In vivo studies on the mechanism of action of the broad spectrum anticonvulsant loreclezole.
Topics: Animals; Anticonvulsants; Diazepam; Electric Stimulation; Kindling, Neurologic; Male; Pentobarbital; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Triazoles | 1992 |
Synthesis and pharmacological evaluation of 6,8-diaryl 1,2,4-triazolo [4,3,-b] and 1,2,3,4,-tetrazolo [1,5-b] pyridazines.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Azoles; Behavior, Animal; Bicuculline; Chemical Phenomena; Chemistry; Electroshock; Hypnotics and Sedatives; Mice; Motor Activity; Pentylenetetrazole; Pyridazines; Seizures; Tetrazoles; Triazoles | 1990 |
Triazolines. 14. 1,2,3-Triazolines and triazoles, a new class of anticonvulsants. Drug design and structure-activity relationships.
Topics: Animals; Anticonvulsants; Electroshock; Mice; Seizures; Structure-Activity Relationship; Triazoles | 1988 |
Anxiolytic effects of a new triazolobenzodiazepine, U-31,889.
Topics: Adult; Animals; Anxiety; Behavior, Animal; Benzodiazepinones; Blood Circulation; Central Nervous System; Computers; Depression; Dogs; Electroencephalography; Female; Flurazepam; Humans; Hypnotics and Sedatives; Leukocyte Count; Male; Middle Aged; Movement Disorders; Respiration; Seizures; Sleep; Sleep Initiation and Maintenance Disorders; Tranquilizing Agents; Triazoles | 1973 |
Pharmacological study of 1-(beta-phenylethyl) triazolo (4,5-c) pyridine hydrochloride, a tranquillizing agent.
Topics: Aggression; Analgesia; Anesthesia; Animals; Anticonvulsants; Autonomic Nervous System; Avoidance Learning; Behavior, Animal; Blood Pressure; Body Temperature; Central Nervous System; Chlorpromazine; Electroencephalography; Female; Humans; Ileum; Male; Mice; Motor Activity; Neuromuscular Junction; Pentobarbital; Pyridines; Rats; Reflex; Reserpine; Respiration; Seizures; Sleep; Tranquilizing Agents; Triazoles; Uterus | 1967 |
Centrally acting isosteric Mannich bases.
Topics: Animals; Azoles; Benzimidazoles; Chemistry, Pharmaceutical; Cyanosis; Indoles; Mice; Motor Activity; Piperazines; Piperidines; Pyrrolidines; Seizures; Triazoles | 1968 |