Compounds > 1-dodecylimidazole
Page last updated: 2024-12-07

1-dodecylimidazole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

1-Dodecylimidazole is a **long-chain alkyl-substituted imidazole**, meaning it is a heterocyclic organic compound with a 12-carbon chain attached to an imidazole ring.

**Here's why it's important for research:**

* **Surfactant Properties:** Its long hydrophobic tail and polar imidazole head make it an effective surfactant. Surfactants are crucial for various applications, including:
* **Emulsions and Microemulsions:** 1-Dodecylimidazole can help stabilize emulsions by reducing interfacial tension between oil and water phases. This is used in fields like pharmaceuticals, cosmetics, and food science.
* **Detergents and Cleaning Agents:** Its ability to solubilize dirt and grease makes it suitable for use in cleaning agents.
* **Nanotechnology:** It can help in the synthesis and stabilization of nanoparticles.
* **Biochemistry and Cell Biology:**
* **Membrane Interaction:** The hydrophobic tail can interact with cell membranes, potentially affecting their fluidity and permeability. This is studied in the context of drug delivery and cell signaling.
* **Enzyme Inhibition:** 1-Dodecylimidazole has been shown to inhibit certain enzymes, particularly those involved in lipid metabolism. This opens up possibilities for drug development.
* **Materials Science:**
* **Polymerization and Catalysis:** It can act as a catalyst in polymerization reactions, leading to the formation of new polymers with unique properties.
* **Organic Electronics:** Its amphiphilic nature makes it a potential candidate for organic electronics applications like solar cells and transistors.

**Current Research Areas:**

* **Drug Delivery:** 1-Dodecylimidazole is being explored as a potential carrier for drug delivery, particularly for hydrophobic drugs.
* **Biocompatible Materials:** Its biocompatibility is being investigated for use in tissue engineering and biomaterial applications.
* **Environmental Remediation:** Research is ongoing to evaluate its potential for removing pollutants from water and soil.

**Overall, 1-dodecylimidazole is a versatile compound with various applications in different fields. Its unique properties make it a valuable tool for research, particularly in areas related to surfactants, biomaterials, and catalysis.**

Cross-References

ID SourceID
PubMed CID78002
CHEMBL ID38032
SCHEMBL ID284539
MeSH IDM0043580

Synonyms (39)

Synonym
q11nxv80s7 ,
ec 224-314-4
5-23-04-00264 (beilstein handbook reference)
unii-q11nxv80s7
imidazole, 1-dodecyl-
1-dodecylimidazole
nsc-307267
4303-67-7
n-dodecylimidazole
1h-imidazole, 1-dodecyl-
nsc307267
nsc 307267
1-laurylimidazole
einecs 224-314-4
brn 0609993
n-laurylimidazole
1-dodecyl-1h-imidazole
CHEMBL38032
AKOS009159356
FT-0607714
SCHEMBL284539
JMTFLSQHQSFNTE-UHFFFAOYSA-N
n-dodecyl imidazole
DTXSID9063403
SY029730
mfcd00278859
J-650001
J-640443
5-ethyl thiophene -2-carboxaldehyde
J-800104
DS-6023
1-dodeclimidazole
AC1319
AMY6319
Q27286867
A872769
CS-0149146
1-dodecylimidazole >98%
HY-138540

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" We suggest that the DNA double-strand breaks result from a cell-mediated process such as release of DNAase from lysosomes or other cellular compartments, that might occur during cellular response to acutely toxic damage."( Relationships among cytotoxicity, lysosomal breakdown, chromosome aberrations, and DNA double-strand breaks.
Armstrong, MJ; Bradley, MO; Galloway, SM; Taylor, VI, 1987)		0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (82)

Assay IDTitleYearJournalArticle
AID73608The compound was evaluated for mean zone diameter (inhibition) against filamentous fungi at 125 ug/mL concentration1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID200311The compound was tested for antifungal activity against Saccharomyces cerevisiae MY1027 using agar dilution assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID94388The compound was evaluated for zone inhibition against Kluyveromyces fragilis MY1113 using disk diffusion assay; 13 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID54849The compound was evaluated for zone inhibition against Cryptococcus laurentii MY1074 using disk diffusion assay; 16 slightly hazy1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID47421The compound was evaluated for zone inhibition against Candida albicans YNB/GLU MY1099 using disk diffusion assay; 9 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID211465The compound was evaluated for zone inhibition against Torulopsis glabrata MY1062 using disk diffusion assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID50133The compound was tested for antifungal activity against Candida guilliermondii MY1019 using agar dilution assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID52330The compound was evaluated for zone inhibition against Cochliobolus miyabeanus (MF4626) using disk diffusion assay; 25 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID54851The compound was evaluated for zone inhibition against Cryptococcus laurentii MY1077 using disk diffusion assay; 22 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID220095The compound was evaluated for mean zone diameter (inhibition) against yeast at the concentration of 250 ug/mL1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID37580The compound was evaluated for zone inhibition against Aspergillus niger (MF442) using disk diffusion assay; 21 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID202857The compound was evaluated for zone inhibition against Saccharomyces cerevisiae YED MY34 using disk diffusion assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID42663The compound was evaluated for zone inhibition against Botrytis allii (MF3587) using disk diffusion assay; 24 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID54848The compound was evaluated for zone inhibition against Cryptococcus laurentii MY1073 using disk diffusion assay; 12 slightly hazy1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID1134923Induction of cell death in mouse P815 cells assessed as [51Cr] release at 1 ug/ml at 5 hrs1979Journal of medicinal chemistry, Sep, Volume: 22, Issue:9
Lysosomotropic agents. 1. Synthesis and cytotoxic action of lysosomotropic detergents.
AID69197Minimum inhibitory concentration (MIC) against Escherichia coli2003Bioorganic & medicinal chemistry letters, Sep-01, Volume: 13, Issue:17
Synthesis of N-alkylated derivatives of imidazole as antibacterial agents.
AID156579The compound was tested for antifungal activity against Penicillium italicum MF2819 using agar dilution assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID39401The compound was tested for antifungal activity against Aspergillus flavus MF0383 using agar dilution assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID47419The compound was evaluated for zone inhibition against Candida albicans (MY1099) using disk diffusion assay; 18 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID47422The compound was evaluated for zone inhibition against Candida albicans(YED) (MY992) using disk diffusion assay; 17 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID48821The compound was tested for antifungal activity against Candida tropicalis MY1012 using agar dilution assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID55189The compound was tested for antifungal activity against Cryptococcus neoformans MY1146 using agar dilution assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID1134925Induction of cell death in mouse P815 cells assessed as [51Cr] release at 9 ug/ml at 5 hrs1979Journal of medicinal chemistry, Sep, Volume: 22, Issue:9
Lysosomotropic agents. 1. Synthesis and cytotoxic action of lysosomotropic detergents.
AID162932Minimum inhibitory concentration (MIC) against Pseudomonas aeruginosa2003Bioorganic & medicinal chemistry letters, Sep-01, Volume: 13, Issue:17
Synthesis of N-alkylated derivatives of imidazole as antibacterial agents.
AID218410The compound was evaluated for zone inhibition against Verticillium serrae (MF3794) using disk diffusion assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID72109The compound was evaluated for zone inhibition against Fusarium oxysporum (MF4014) using disk diffusion assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID39858The compound was tested for antifungal activity against Aspergillus fumigatus MF4839 using agar dilution assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID207688Minimum inhibitory concentration (MIC) against Staphylococcus aureus2003Bioorganic & medicinal chemistry letters, Sep-01, Volume: 13, Issue:17
Synthesis of N-alkylated derivatives of imidazole as antibacterial agents.
AID164233Minimum bacterial concentration (MBC) against Pseudomonas aeruginosa2003Bioorganic & medicinal chemistry letters, Sep-01, Volume: 13, Issue:17
Synthesis of N-alkylated derivatives of imidazole as antibacterial agents.
AID48601The compound was tested for antifungal activity against Candida stellatoidea MY1017 using agar dilution assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID49092The compound was tested for antifungal activity against Candida albicans MY0992 using agar dilution assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID155495The compound was evaluated for zone inhibition against Phoma sp (MF4332) using disk diffusion assay; 23 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID69601Minimum bacterial concentration (MBC) against Escherichia coli2003Bioorganic & medicinal chemistry letters, Sep-01, Volume: 13, Issue:17
Synthesis of N-alkylated derivatives of imidazole as antibacterial agents.
AID49094The compound was tested for antifungal activity against Candida albicans MY1055 using agar dilution assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID47417The compound was evaluated for zone inhibition against Candida albicans (MY1055) using disk diffusion assay; 16 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID49093The compound was tested for antifungal activity against Candida albicans MY1013 using agar dilution assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID47414The compound was evaluated for zone inhibition against Candida albicans (MY1029) using disk diffusion assay; 15 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID39550The compound was evaluated for zone inhibition against Aspergillus fumigatus MF (4839) using disk diffusion assay; 20 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID156438The compound was evaluated for zone inhibition against Penicillium sp (MF5014) using disk diffusion assay; 22 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID48612The compound was evaluated for zone inhibition against Candida tropicalis MY1012 using disk diffusion assay; 25 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID211475The compound was tested for antifungal activity against Torulopsis glabrata MY1059 using agar dilution assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID55188The compound was tested for antifungal activity against Cryptococcus neoformans MY1051 using agar dilution assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID1134921Induction of cell death in mouse P815 cells assessed as [51Cr] release at 50 ug/ml at 5 hrs1979Journal of medicinal chemistry, Sep, Volume: 22, Issue:9
Lysosomotropic agents. 1. Synthesis and cytotoxic action of lysosomotropic detergents.
AID206851Minimum bacterial concentration (MBC) against Staphylococcus aureus2003Bioorganic & medicinal chemistry letters, Sep-01, Volume: 13, Issue:17
Synthesis of N-alkylated derivatives of imidazole as antibacterial agents.
AID48243The compound was tested for antifungal activity against Candida rugosa MY1022 using agar dilution assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID220097The compound was evaluated for mean zone diameter (inhibition) against yeast at the concentration of 62.5 ug/mL1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID48820The compound was tested for antifungal activity against Candida tropicalis MY1011 using agar dilution assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID48236The compound was tested for antifungal activity against Candida pseudotropicalis MY1040 using agar dilution assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID202856The compound was evaluated for zone inhibition against Saccharomyces cerevisiae MY410 using disk diffusion assay; 9 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID183051Compound was tested in vitro for inhibition of Cholesterol biosynthesis in rat liver slices, % inhibition of [14C]acetate incorporation in cholesterol1986Journal of medicinal chemistry, Mar, Volume: 29, Issue:3
N-imidazolylchroman-4-ones, N-imidazolyl-1-tetralones, and their alcohols as hypolipemic agents raising high-density lipoproteins.
AID52221The compound was evaluated for zone inhibition against Ceratocystis ulmi (MF4042) using disk diffusion assay; 31 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID54844The compound was evaluated for zone inhibition against Cryptococcus albidus MY1070 using disk diffusion assay; 23 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID156562The compound was evaluated for zone inhibition against Penicillium sp (MF5020) using disk diffusion assay; 21 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID73611The compound was evaluated for mean zone diameter (inhibition) against filamentous fungi at 62.5 ug/mL concentration1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID47567The compound was evaluated for zone inhibition against Candida albicans(YNB) (MY992) using disk diffusion assay; 9 slightly hazy1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID183054Compound was tested in vitro for inhibition of Cholesterol biosynthesis in rat liver slices, % inhibition of [14C]acetate incorporation in neutral lipids1986Journal of medicinal chemistry, Mar, Volume: 29, Issue:3
N-imidazolylchroman-4-ones, N-imidazolyl-1-tetralones, and their alcohols as hypolipemic agents raising high-density lipoproteins.
AID210983The compound was evaluated for zone inhibition against Trichoderma sp (MF4064) using disk diffusion assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID52222The compound was evaluated for zone inhibition against Cercospora beticola (MF4608) using disk diffusion assay; 22 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID49096The compound was tested for antifungal activity against Candida albicans My1029 using agar dilution assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID1134924Induction of cell death in mouse P815 cells assessed as [51Cr] release at 3 ug/ml at 5 hrs1979Journal of medicinal chemistry, Sep, Volume: 22, Issue:9
Lysosomotropic agents. 1. Synthesis and cytotoxic action of lysosomotropic detergents.
AID48070The compound was evaluated for zone inhibition against Candida pseudotropicalis MY1100 using disk diffusion assay; 14 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID202243The compound was evaluated for zone inhibition against Scopulariopsis communis (MF3769) using disk diffusion assay; 23 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID48058The compound was tested for antifungal activity against Candida parapsilosis MY1010 using agar dilution assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID50125The compound was evaluated for zone inhibition against Candida guilliermondii MY1019 using disk diffusion assay; 23 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID211477The compound was evaluated for zone inhibition against Torulopsis hansenii MY321 using disk diffusion assay; 20 slightly hazy1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID1134926Induction of cell death in mouse P815 cells assessed as [51Cr] release at 27 ug/ml at 5 hrs1979Journal of medicinal chemistry, Sep, Volume: 22, Issue:9
Lysosomotropic agents. 1. Synthesis and cytotoxic action of lysosomotropic detergents.
AID43624The compound was evaluated for zone inhibition against Brettanomyces bruxellensis (MY315) using disk diffusion assay; 16 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID35539The compound was evaluated for zone inhibition against Alternaria solani (MF3550) using disk diffusion assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID39385The compound was evaluated for zone inhibition against Aspergillus flavus (MF383) using disk diffusion assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID210986The compound was evaluated for zone inhibition against Trichoderma lignorum (MF3560) using disk diffusion assay; 24 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID48241The compound was evaluated for zone inhibition against Candida rugosa MY1022 using disk diffusion assay; 30 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID156560The compound was evaluated for zone inhibition against Penicillium sp (MF5016) using disk diffusion assay; 25 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID220094The compound was evaluated for mean zone diameter (inhibition) against yeast at the concentration of 125 ug/mL1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID37577The compound was evaluated for zone inhibition against Aspergillus niger (MF11) using disk diffusion assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID49095The compound was tested for antifungal activity against Candida albicans MY1058 using agar dilution assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID73609The compound was evaluated for mean zone diameter (inhibition) against filamentous fungi at 250 ug/mL concentration1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID52217The compound was evaluated for zone inhibition against Cephalosporium sp (MF4641) using disk diffusion assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID200212The compound was evaluated for zone inhibition against Rhizomucor miehei (MF4784) using disk diffusion assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID48057The compound was tested for antifungal activity against Candida parapsilosis MY1009 using agar dilution assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID50305The compound was tested for antifungal activity against Candida krusei MY1020 using agar dilution assay1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID213467The compound was evaluated for zone inhibition against Ustilago zeae (MF1996) using disk diffusion assay; 28 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
AID47413The compound was evaluated for zone inhibition against Candida albicans (MY1028) using disk diffusion assay; 18 Fuzzy edges1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-199010 (62.50)18.7374
1990's4 (25.00)18.2507
2000's1 (6.25)29.6817
2010's1 (6.25)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.41

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.41 (24.57)
Research Supply Index2.83 (2.92)
Research Growth Index4.25 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.41)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
cytosine
[no description available]		1.9710aminopyrimidine;
pyrimidine nucleobase;
pyrimidone		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
1-methylimidazole
1-methyl-1H-imidazole : A 1H-imidazole having a methyl substituent at the N-1 position.		1.9510imidazoles
3-methylcholanthrene
Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.. 3-methylcholanthrene : A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.		1.9710ortho- and peri-fused polycyclic arenearyl hydrocarbon receptor agonist;
carcinogenic agent
verapamil
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.		1.9710aromatic ether;
nitrile;
polyether;
tertiary amino compound
clofibrate
angiokapsul: contains clofibrate & insoitolnicotinate		1.9610aromatic ether;
ethyl ester;
monochlorobenzenes		anticholesteremic drug;
antilipemic drug;
geroprotector;
PPARalpha agonist
fenofibrate
Pharmavit: a polyvitamin product, comprising vitamins A, D2, B1, B2, B6, C, E, nicotinamide, & calcium pantothene; may be a promising agent for application to human populations exposed to carcinogenic and genetic hazards of ionizing radiation; RN from CHEMLINE		1.9610aromatic ether;
chlorobenzophenone;
isopropyl ester;
monochlorobenzenes		antilipemic drug;
environmental contaminant;
geroprotector;
xenobiotic
ketoconazole
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.		1.9710dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine
nifedipine
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.		1.9710C-nitro compound;
dihydropyridine;
methyl ester		calcium channel blocker;
human metabolite;
tocolytic agent;
vasodilator agent
phenobarbital
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.		1.9610barbituratesanticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative
sucrose
Saccharum: A plant genus of the family POACEAE widely cultivated in the tropics for the sweet cane that is processed into sugar.		1.9710glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
leucine
Leucine: An essential branched-chain amino acid important for hemoglobin formation.. leucine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group.		2.3820amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
4-methylpyridine
4-methylpyridine: structure in first source. 4-methylpyridine : A methylpyridine in which the methyl substituent is at position 4.		1.9510methylpyridine
4-methylmorpholine
[no description available]		1.9510
2-picoline
2-picoline: structure in first source. 2-methylpyridine : A methylpyridine carrying a methyl substituent at position 2.		1.9510methylpyridine
dodecylamine
dodecylamine: RN given refers to parent cpd		1.9510primary aliphatic amine
ammonium chloride
Ammonium Chloride: An acidifying agent that has expectorant and diuretic effects. Also used in etching and batteries and as a flux in electroplating.. ammonium chloride : An inorganic chloride having ammonium as the counterion.		2.3720ammonium salt;
inorganic chloride		ferroptosis inhibitor
daunorubicin
Daunorubicin: A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.. anthracycline : Anthracyclines are polyketides that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.. daunorubicin : A natural product found in Actinomadura roseola.		1.9710aminoglycoside antibiotic;
anthracycline;
p-quinones;
tetracenequinones		antineoplastic agent;
bacterial metabolite
phenyl acetate
phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.		1.9410benzenes;
phenyl acetates
propiconazole
Orbit: Bony cavity that holds the eyeball and its associated tissues and appendages.		1.9710conazole fungicide;
cyclic ketal;
dichlorobenzene;
triazole fungicide;
triazoles		antifungal agrochemical;
EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor;
environmental contaminant;
xenobiotic
1-n-butylimidazole
[no description available]		2.0110
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		1.97101,2,3-triazole
pirinixil
pirinixil: structure		1.9610
n-dodecylmorpholine
N-dodecylmorpholine: RN given refers to parent cpd		2.6530
deoxyglucose
Deoxyglucose: 2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.. deoxyglucose : A deoxyhexose comprising glucose having at least one hydroxy group replaced by hydrogen.		2.1310
e 64
E 64: cysteine protease inhibitor of microbial origin, which inhibits cathepsin B (EC 3.4.22.1) and cathepsin L (EC 3.4.22.-)		2.3820dicarboxylic acid monoamide;
epoxy monocarboxylic acid;
guanidines;
L-leucine derivative;
zwitterion		antimalarial;
antiparasitic agent;
protease inhibitor
demecolcine
Demecolcine: An alkaloid isolated from Colchicum autumnale L. and used as an antineoplastic.. (-)-demecolcine : A secondary amino compound that is (S)-colchicine in which the N-acetyl group is replaced by an N-methyl group. Isolable from the autumn crocus, Colchicum autumnale, it is less toxic than colchicine and is used as an antineoplastic.		1.9710alkaloid;
secondary amino compound		antineoplastic agent;
microtubule-destabilising agent
mevalonic acid
Mevalonic Acid: A dihydroxy monocarboxylic acid and precursor in the biosynthetic pathway known as the mevalonate pathway, which produces terpenes and steroids that are vital for diverse cellular functions.. mevalonic acid : A racemate composed of equimolar amounts of (R)- and (S)-mevalonic acid.. (R)-mevalonic acid : The (R)-enantiomer of mevalonic acid.		1.94103,5-dihydroxy-3-methylpentanoic acid
squalene
Addavax: an oil-water nanoemulsion and adjuvant containing squalene, Tween 80, and sorbitane trioleate		6.9410triterpenehuman metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
cystine
[no description available]		1.9710
2,3-oxidosqualene
2,3-oxidosqualene: an oxidized derivative of SQUALENE that can fold in several ways: chair-boat-chair-boat to LANOSTEROL; chair-chair-chair-boat to dammarane; or all chair to hopane and on to cycloartenol; RN given refers to (all-Z)-isomer. 2,3-epoxysqualene : A squalene triterpenoid obtained by formal epoxidation across the 2,3 C=C bond of squalene.		6.9410epoxide;
squalene triterpenoid
ammonium sulfate
Ammonium Sulfate: Sulfuric acid diammonium salt. It is used in CHEMICAL FRACTIONATION of proteins.. ammonium sulfate : An inorganic sulfate salt obtained by reaction of sulfuric acid with two equivalents of ammonia. A high-melting (decomposes above 280degreeC) white solid which is very soluble in water (70.6 g/100 g water at 0degreeC; 103.8 g/100 g water at 100degreeC), it is widely used as a fertilizer for alkaline soils.		1.9710ammonium salt;
inorganic sulfate salt		fertilizer
gentamicin sulfate
[no description available]		2.0110
bropirimine
[no description available]		1.9710pyrimidines
concanavalin a
Concanavalin A: A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.		1.9710
ConditionIndicatedRelationship StrengthStudiesTrials
Experimental Neoplasms
[description not available]		01.9510
Mast-Cell Sarcoma
A unifocal malignant tumor that consists of atypical pathological MAST CELLS without systemic involvement. It causes local destructive growth in organs other than in skin or bone marrow.		01.9510
Elevated Cholesterol
[description not available]		01.9610
Hypercholesterolemia
A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.		01.9610
Glial Cell Tumors
[description not available]		02.1310
Glioma
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)		02.1310
Bladder Cancer
[description not available]		01.9810
Urinary Bladder Neoplasms
Tumors or cancer of the URINARY BLADDER.		01.9810
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.		01.9710
Abnormalities, Autosome
[description not available]		02.3820
Acute Myelogenous Leukemia
[description not available]		01.9710
Leukemia, Myeloid, Acute
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.		01.9710
Cystine Diathesis
[description not available]		01.9710
Cystinosis
A metabolic disease characterized by the defective transport of CYSTINE across the lysosomal membrane due to mutation of a membrane protein cystinosin. This results in cystine accumulation and crystallization in the cells causing widespread tissue damage. In the KIDNEY, nephropathic cystinosis is a common cause of RENAL FANCONI SYNDROME.		01.9710
Cherry Red Spot Myoclonus Syndrome
[description not available]		01.9710