Roles > eukaryotic initiation factor 4F inhibitor
Page last updated: 2024-08-05 15:39:24
eukaryotic initiation factor 4F inhibitor
Any compound that inihibits the mammalian protein, eukaryotic initiation factor 4F.
ChEBI ID: 137079
Members (2)
| Member | Definition | Class |
|---|
| pateamine a | A marine macrodiolide that is isolated from the sponge Mycale hentscheli and exhibits anticancer and antiviral properties | pateamine |
| ribavirin 5'-triphosphate | A 1-ribosyltriazole that is ribavirin in which the hydroxy group at the 5'-position is replaced by a triphosphate group. It is the active metabolite of the antiviral agent ribavirin. | ribavirin 5'-triphosphate |
Research
Studies (61)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|
| pre-1990 | 5 (8.20) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 25 (40.98) | 29.6817 |
| 2010's | 27 (44.26) | 24.3611 |
| 2020's | 4 (6.56) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 8 (12.90%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 54 (87.10%) | 84.16% |
Protein Targets (2)
Inhibition Measurements
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| Chain A, NDP kinase | Dictyostelium discoideum | Kd | 24.0000 | 1 | 1 |