Page last updated: 2024-10-15

recombinant soluble cd4

Description

recombinant soluble CD4: recombinant CD4 with the transmembrane and C-terminal regions deleted; blocks in vitro infectivity of HIV [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID156963638
MeSH IDM0205969

Synonyms (1)

Synonym
recombinant soluble cd4

Effects

ExcerptReference
"Recombinant soluble CD4 (sT4) has been shown to inhibit infectivity of HIV. "( Recombinant human soluble CD4 does not inhibit immune function in cynomolgus monkeys.
Bugelski, PJ; Morgan, DG; Thiem, PA; Truneh, A, 1991
)

Pharmacokinetics

ExcerptReference
" Pharmacokinetic parameters for ddC and ST4 were calculated based on plasma and urine concentrations of ddC and plasma concentrations of ST4."( Pharmacokinetic evaluation of drug interactions with anti-human immunodeficiency virus drugs. V. Effect of soluble CD4 on 2',3'-dideoxycytidine kinetics in monkeys.
Crysler, CS; Fong, KL; Gallo, JM; Mehta, M; Qian, M; Swagler, AR,
)

Compound-Compound Interactions

ExcerptReference
"CD4-based molecules were tested in combination with HIV-1-neutralizing antibodies directed against the V3 loop of gp120 or against gp41, for inhibition of HIV-1 envelope-mediated cell fusion."( Synergistic inhibition of HIV-1 envelope-mediated cell fusion by CD4-based molecules in combination with antibodies to gp120 or gp41.
Allaway, GP; Beaudry, GA; Maddon, PJ; Ryder, AM, 1993
)

Dosage Studied

ExcerptReference
" The kinetic information provides a basis for rational dosage design for combination chemotherapeutic regimens of ddC and ST4 in human immunodeficiency virus infection."( Pharmacokinetic evaluation of drug interactions with anti-human immunodeficiency virus drugs. V. Effect of soluble CD4 on 2',3'-dideoxycytidine kinetics in monkeys.
Crysler, CS; Fong, KL; Gallo, JM; Mehta, M; Qian, M; Swagler, AR,
)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (58)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's32 (55.17)18.2507
2000's8 (13.79)29.6817
2010's15 (25.86)24.3611
2020's3 (5.17)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (3.28%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other59 (96.72%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]