clothianidin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
clothianidin : An N-nitro compound consisting of 2-nitroguanidine having a (2-chloro-1,3-thiazol-5-yl)methyl group at position 1 and a methyl group at position 3. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
(E)-clothianidin : A clothiadin that has E configuration at the C=N bond of the nitroguanidine moiety. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 135779804 |
| CHEBI ID | 39178 |
| MeSH ID | M0458704 |
| PubMed CID | 86287519 |
| CHEMBL ID | 259727 |
| CHEBI ID | 39177 |
| SCHEMBL ID | 21214 |
| MeSH ID | M0458704 |
| Synonym |
|---|
| 210880-92-5 |
| clothianidin |
| CHEBI:39178 |
| n-(2-chloro-5-thiazolylmethyl)-n'-methyl-n-nitroguanidine |
| n-[(2-chloro-5-thiazolyl)methyl]-n'-methyl-n-nitroguanidine |
| 1-(2-chlorothiazol-5-ylmethyl)-2-nitro-3-methyl-guanidine |
| PGOOBECODWQEAB-UHFFFAOYSA-N |
| n'-[(2-chloro-1,3-thiazol-5-yl)methyl]-n-methyl-n''-nitroguanidine |
| (e)-1-[(2-chloro-1,3-thiazol-5-yl)methyl]-3-methyl-2-nitroguanidine |
| (e)-clothianidin |
| 1-[(2-chloro-1,3-thiazol-5-yl)methyl]-3-methyl-2-nitroguanidine |
| CHEBI:39177 , |
| (e)-n-(2-chloro-5-thiazolyl)methyl-n'-methyl-n''-nitroguanidine |
| NCGC00163946-01 |
| clothianidin [iso] |
| hsdb 7281 |
| poncho 600 |
| guanidine, n-((2-chloro-5-thiazolyl)methyl)-n'-methyl-n''-nitro-, (c(e))- |
| NCGC00163946-02 |
| CHEMBL259727 |
| clothianidine |
| NCGC00163946-03 |
| C18508 |
| dtxsid2034465 , |
| tox21_301191 |
| dtxcid0014465 |
| NCGC00255089-01 |
| cas-210880-92-5 |
| A814674 |
| 205510-53-8 |
| 1-(2-chlorothiazol-5-yl)-1,2-dimethyl-3-nitro-guanidine |
| 2v9906abkq , |
| ((e)-1-(2-chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine) |
| pancho |
| ec 433-460-1 |
| ti-435 |
| guanidine, n-(2-chloro-5-thiazolyl)methyl-n'-methyl-n''-nitro-, (e)- |
| (e)-1-(2-chloro-1,3-thiazol-5-ylmethyl)-3- methyl-2-nitroguanidine (clothianidin) |
| unii-2v9906abkq |
| ccris 9264 |
| (e)-1-(2-chloro-1,3-thiazole-5-ylmethyl)-3-methyl-2-nitroguanidine |
| poncho |
| AKOS015900249 |
| SCHEMBL21214 |
| clothianidin [mi] |
| cga-322704 |
| n-((2-chloro-5-thiazolyl)methyl)-n'-methyl-n''-nitroguanidine |
| (e)-1-(2-chloro-1,3-thiazol-5-yl methyl)-3-methyl-2-nitroguanidine |
| 1-(2-chloro-5-thiazolylmethyl)-3-methyl-2-nitroguanidine |
| clothianidin, pestanal(r), analytical standard |
| mfcd06200753 |
| bdbm50486231 |
| AMY22333 |
| guanidine, n-[(2-chloro-5-thiazolyl)methyl]-n'-methyl-n''-nitro-, [c(e)]- |
| guanidine, n-[(2-chloro-5-thiazolyl)methyl]-n'-methyl-n''-nitro- |
| CS-0112847 |
| HY-133167 |
| AKOS040744778 |
The residue detection method and field dissipation dynamics of the pymetrozine-clothianidin mixture in strawberries were investigated. QuEChERS pretreatment and LC-MS/MS analysis was used to provide a reference for the safe use of the mixture.
| Excerpt | Reference | Relevance |
|---|---|---|
| " Toxic equivalence relative to imidacloprid was estimated through a 3-point response average of equivalencies calculated at 20%, 50%, and 90% lethal and effect concentrations." | ( Comparative chronic toxicity of imidacloprid, clothianidin, and thiamethoxam to Chironomus dilutus and estimation of toxic equivalency factors. Cavallaro, MC; Headley, JV; Liber, K; Morrissey, CA; Peru, KM, 2017) | 0.46 |
| " Considering all lines of evidence, the quality of the studies included in this analysis was variable, but the results of the studies were consistent and point to the same conclusion - that IMI had no adverse effects on viability of the honeybee colony." | ( Quantitative weight of evidence assessment of higher-tier studies on the toxicity and risks of neonicotinoids in honeybees. 2. Imidacloprid. Solomon, KR; Stephenson, GL, 2017) | 0.46 |
| " For exposures via dust, there were no adverse effects because of these applications and there were no exposures greater than the NOAED for CTD in nectar and pollen." | ( Quantitative weight of evidence assessment of higher tier studies on the toxicity and risks of neonicotinoids in honeybees. 3. Clothianidin. Solomon, KR; Stephenson, GL, 2017) | 0.46 |
| " Although some risks were identified for potential exposures via guttation fluid, this route of exposure is incomplete; no apparent adverse effects were observed in field studies." | ( Quantitative weight of evidence assessment of higher tier studies on the toxicity and risks of neonicotinoids in honeybees. 4. Thiamethoxam. Solomon, KR; Stephenson, GL, 2017) | 0.46 |
| "0 toxic unit tended to shift sex-ratios toward more male-dominated populations." | ( Can chronic exposure to imidacloprid, clothianidin, and thiamethoxam mixtures exert greater than additive toxicity in Chironomus dilutus? Headley, JV; Liber, K; Maloney, EM; Morrissey, CA; Peru, KM, 2018) | 0.48 |
| " Using experimental in-situ enclosures (limnocorrals), we exposed wetland insects to single-compounds and binary mixtures at equitoxic concentrations (1 toxic unit under the principle of Concentration Addition)." | ( Neonicotinoid insecticide mixtures: Evaluation of laboratory-based toxicity predictions under semi-controlled field conditions. Headley, JV; Liber, K; Maloney, EM; Morrissey, CA; Peru, KM, 2018) | 0.48 |
| "The residue detection method and field dissipation dynamics of the pymetrozine-clothianidin mixture in strawberries were investigated combining QuEChERS pretreatment and LC-MS/MS analysis to provide a reference for the safe use of pymetrozine and clothianidin mixture on strawberries." | ( Residues, dissipation, and safety evaluation of pymetrozine-clothianidin mixture in strawberry. Chen, L; Fang, X; Ren, W; Xu, F; Zha, X, 2021) | 0.62 |
| "Neonicotinoid pesticides (NN) were recently reported to exhibit adverse effects in higher vertebrates." | ( Developmental stage-specific exposure and neurotoxicity evaluation of low-dose clothianidin during neuronal circuit formation. Hara, Y; Hirano, T; Hoshi, N; Ikenaka, Y; Ishida, Y; Kimura, M; Mantani, Y; Murata, M; Shoda, A; Tabuchi, Y; Yokoyama, T; Yonoichi, S, 2023) | 0.91 |
The lethal toxicity of Cr alone and in combination with the neonicotinoid insecticide clothianidin and the ergosterol-biosynthesis-inhibiting fungicide propiconazole was assessed in Apis mellifera adults.
| Excerpt | Reference | Relevance |
|---|---|---|
| "The objective of this study was to develop analytical method based on optimized dispersive liquid-liquid microextraction (DLLME) as a pretreatment procedure combined with reversed phase liquid chromatographic separation on C18 column and isocratic elution for simultaneous MS/MS determination of selected neonicotinoid insecticides in honey." | ( Multi-residue method for determination of selected neonicotinoid insecticides in honey using optimized dispersive liquid-liquid microextraction combined with liquid chromatography-tandem mass spectrometry. Banjac, V; Franko, M; Guzsvány, V; Jovanov, P; Lazić, S; Sakač, M; Šarić, B, 2013) | 0.39 |
| " Therefore, the efficacy of clothianidin seed treatments combined with spot applications of clothianidin granules at the bud stage of cotton was evaluated to control piercing-sucking pests during the entire cotton growing season." | ( Seed Treatment Combined with a Spot Application of Clothianidin Granules Prolongs the Efficacy of Controlling Piercing-Sucking Insect Pests in Cotton Fields. Li, B; Lin, J; Mu, W; Wang, Y; Zhang, X; Zhang, Z; Zhao, Y, 2017) | 0.46 |
| " In this study, the lethal toxicity of Cr alone and in combination with the neonicotinoid insecticide clothianidin and the ergosterol-biosynthesis-inhibiting fungicide propiconazole was assessed in Apis mellifera adults." | ( Lethal effects of Cr(III) alone and in combination with propiconazole and clothianidin in honey bees. Blasioli, S; Braschi, I; Medrzycki, P; Molowny-Horas, R; Porrini, C; Renzi, T; Sgolastra, F; Tosi, S, 2018) | 0.48 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "7 ng/g) were not correlated with use history, and plant bioavailability was 6% of clothianidin soil residues." | ( Clothianidin in agricultural soils and uptake into corn pollen and canola nectar after multiyear seed treatment applications. Allen, R; Bondarenko, S; Dyer, DG; Heinemann, O; McConnell, LL; Xu, T, 2016) | 0.43 |
| " The decreased bioavailability and increased persistence of THI resulted mainly from the higher sorption capacity of BC450 to THI and CLO, which, in turn, enhanced the soil sorption capacity." | ( Biochar reduced Chinese chive (Allium tuberosum) uptake and dissipation of thiamethoxam in an agricultural soil. Jiang, H; Li, F; Li, Y; Sun, K; Suo, F; You, X; Zhang, C; Zhang, G; Zhao, M; Zheng, H, 2020) | 0.56 |
Clothianidin was found to induce mortality in larvae, with highest survival in control groups. The dose-response relationship was unclear.
| Role | Description |
|---|---|
| neonicotinoid insectide | A class of neuro-active insecticides that act at the nicotinic acetylcholine receptor. |
| nicotinic acetylcholine receptor agonist | An agonist that selectively binds to and activates a nicotinic acetylcholine receptor. |
| neonicotinoid insectide | A class of neuro-active insecticides that act at the nicotinic acetylcholine receptor. |
| environmental contaminant | Any minor or unwanted substance introduced into the environment that can have undesired effects. |
| xenobiotic | A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. |
| neonicotinoid insectide | A class of neuro-active insecticides that act at the nicotinic acetylcholine receptor. |
| nicotinic acetylcholine receptor agonist | An agonist that selectively binds to and activates a nicotinic acetylcholine receptor. |
| neonicotinoid insectide | A class of neuro-active insecticides that act at the nicotinic acetylcholine receptor. |
| environmental contaminant | Any minor or unwanted substance introduced into the environment that can have undesired effects. |
| xenobiotic | A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| clothianidin | An N-nitro compound consisting of 2-nitroguanidine having a (2-chloro-1,3-thiazol-5-yl)methyl group at position 1 and a methyl group at position 3. |
| 2-nitroguanidine derivative | Any nitroguanidine derivative resulting from the replacement of one or more hydrogens of 2-nitroguanidine by an organyl group. |
| 1,3-thiazoles | |
| organochlorine compound | An organochlorine compound is a compound containing at least one carbon-chlorine bond. |
| clothianidin | An N-nitro compound consisting of 2-nitroguanidine having a (2-chloro-1,3-thiazol-5-yl)methyl group at position 1 and a methyl group at position 3. |
| 2-nitroguanidine derivative | Any nitroguanidine derivative resulting from the replacement of one or more hydrogens of 2-nitroguanidine by an organyl group. |
| 1,3-thiazoles | |
| organochlorine compound | An organochlorine compound is a compound containing at least one carbon-chlorine bond. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| AR protein | Homo sapiens (human) | Potency | 17.7155 | 0.0002 | 21.2231 | 8,912.5098 | AID1259243; AID1259247 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 0.0891 | 0.0002 | 14.3764 | 60.0339 | AID588532 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 61.1306 | 0.0006 | 27.2152 | 1,122.0200 | AID651741 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 28.1838 | 0.0023 | 19.5956 | 74.0614 | AID651743 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 (µMol) | 1,000.0000 | 0.0340 | 3.9871 | 10.0000 | AID1082239 |
| Acetylcholine receptor subunit beta-like 2 | Drosophila melanogaster (fruit fly) | IC50 (µMol) | 0.0023 | 0.0023 | 0.8531 | 4.0000 | AID1101022 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1111955 | Insecticidal activity against imidacloprid-resistant Aphis gossypii RF45 (cotton aphid) in cotton leaves assessed as mortality measured after 48 hr by dipping method | 2011 | Pest management science, Dec, Volume: 67, Issue:12 | Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii. |
| AID1104227 | Inhibition of Ceutorhynchus obstrictus preimaginal development in Brassica napus L. Ryder pods of plant developed from compound treated seeds assessed as decrease in number of exit holes formed per pod by third-instar larvae at 600 g/L FS | 2009 | Pest management science, Dec, Volume: 65, Issue:12 | Responses of the cabbage seedpod weevil, Ceutorhynchus obstrictus (Marsham) (Coleoptera: Curculionidae), to seed treatments of canola (Brassica napus L.) with the neonicotinoid compounds clothianidin and imidacloprid. |
| AID1111083 | Insecticidal activity against Anomala orientalis assessed as mortality after 10 days | 2010 | Pest management science, Jan, Volume: 66, Issue:1 | Variation in the laboratory susceptibility of turf-infesting white grubs (Coleoptera: Scarabaeidae) to biological, biorational and chemical control products. |
| AID1112899 | Insecticidal activity against Myzus persicae 4106A (green peach aphid) fed on compound treated chinese cabbage discs after 72 hr | 2013 | Pest management science, May, Volume: 69, Issue:5 | Investigating the mode of action of sulfoxaflor: a fourth-generation neonicotinoid. |
| AID1111081 | Insecticidal activity against Anomala orientalis assessed as mortality after 30 days | 2010 | Pest management science, Jan, Volume: 66, Issue:1 | Variation in the laboratory susceptibility of turf-infesting white grubs (Coleoptera: Scarabaeidae) to biological, biorational and chemical control products. |
| AID1111953 | Insecticidal activity against imidacloprid-resistant Aphis gossypii (cotton aphid) in cotton leaves assessed as reduction in body weight at LC20 concentration measured after 24 hr by dipping method (Rvb = 0.33 +/- 0.0004 mg/aphid) | 2011 | Pest management science, Dec, Volume: 67, Issue:12 | Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii. |
| AID1111949 | Insecticidal activity against imidacloprid-resistant Aphis gossypii (cotton aphid) in cotton leaves assessed as inhibition of honeydew excretion at LC20 concentration measured after 72 hr by dipping method | 2011 | Pest management science, Dec, Volume: 67, Issue:12 | Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii. |
| AID1082238 | Inhibition of Oryctolagus cuniculus (rabbit) AOX in liver cytosol | 2011 | Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9 | Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition. |
| AID1112900 | Insecticidal activity against neonicotinoid-resistant Myzus persicae FRC-P (green peach aphid) fed on compound treated chinese cabbage discs after 72 hr | 2013 | Pest management science, May, Volume: 69, Issue:5 | Investigating the mode of action of sulfoxaflor: a fourth-generation neonicotinoid. |
| AID1112209 | Insecticidal activity against Popillia japonica assessed as reduction in leaf damage measured up to 63 days post treatment by laboratory bioassay | 2012 | Pest management science, Apr, Volume: 68, Issue:4 | Soil application of neonicotinoid insecticides for control of insect pests in wine grape vineyards. |
| AID1101017 | Competitive inhibition of nicotinic acetylcholine receptor in Drosophila melanogaster head membrane using [3H]IMI as substrate incubated for 5 min prior to substrate addition measured after 90 min by Sctachard plot analysis | 2000 | Journal of neurochemistry, Sep, Volume: 75, Issue:3 | Insect nicotinic acetylcholine receptor: conserved neonicotinoid specificity of [(3)H]imidacloprid binding site. |
| AID1112218 | Insecticidal activity against Popillia japonica at 500 g/kg WG assessed as moribund behaviour measured after 24 to 56 days by irrigation injection method | 2012 | Pest management science, Apr, Volume: 68, Issue:4 | Soil application of neonicotinoid insecticides for control of insect pests in wine grape vineyards. |
| AID1112861 | Insecticidal activity against second generation Blissus occiduus in buffalograss under field condition assessed as reduction in number at 89.7 kg/ha measured 28 days after treatment | 2013 | Pest management science, Feb, Volume: 69, Issue:2 | Effect of distribution and concentration of topically applied neonicotinoid insecticides in buffalograss, Buchloe dactyloides, leaf tissues on the differential mortality of Blissus occiduus under field conditions. |
| AID1111954 | Resistance ratio, LC50 for Aphis gossypii RF45 (cotton aphid) to LC50 for Aphis gossypii SS | 2011 | Pest management science, Dec, Volume: 67, Issue:12 | Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii. |
| AID1111947 | Insecticidal activity against imidacloprid-resistant Aphis gossypii (cotton aphid) in cotton leaves assessed as fecundity at LC20 concentration | 2011 | Pest management science, Dec, Volume: 67, Issue:12 | Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii. |
| AID1082231 | Inhibition of Oryctolagus cuniculus (rabbit) AOX in liver cytosol at IC50 concentration | 2011 | Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9 | Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition. |
| AID1112903 | Displacement of [3H]-methyl-SFX from nAChR in Myzus persicae 4106A (green peach aphid) membrane after 70 min | 2013 | Pest management science, May, Volume: 69, Issue:5 | Investigating the mode of action of sulfoxaflor: a fourth-generation neonicotinoid. |
| AID1104231 | Effect on Ceutorhynchus obstrictus oviposition in Brassica napus L. Ryder pods of plant developed from compound treated seeds assessed as number of eggs deposited at 600 g/L FS by microscopic analysis | 2009 | Pest management science, Dec, Volume: 65, Issue:12 | Responses of the cabbage seedpod weevil, Ceutorhynchus obstrictus (Marsham) (Coleoptera: Curculionidae), to seed treatments of canola (Brassica napus L.) with the neonicotinoid compounds clothianidin and imidacloprid. |
| AID1080614 | Displacement of [3H]IMI from nicotinic acetylcholine receptor in Drosophila melanogaster brain | 2009 | Journal of agricultural and food chemistry, Mar-25, Volume: 57, Issue:6 | Neonicotinoid substituents forming a water bridge at the nicotinic acetylcholine receptor. |
| AID318726 | Displacement of [3H]EPI from Aplysia AChBP expressed in HEK293S cells by scintillation proximity assay | 2007 | Proceedings of the National Academy of Sciences of the United States of America, May-22, Volume: 104, Issue:21 | Mapping the elusive neonicotinoid binding site. |
| AID1082243 | Phytotoxicity against Spinacia oleracea (spinach) seedlings assessed as lesions at 100 ppm after 9 days | 2011 | Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9 | Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition. |
| AID1111084 | Insecticidal activity against Amphimallon majalis (European chafer) assessed as mortality after 30 days | 2010 | Pest management science, Jan, Volume: 66, Issue:1 | Variation in the laboratory susceptibility of turf-infesting white grubs (Coleoptera: Scarabaeidae) to biological, biorational and chemical control products. |
| AID1111086 | Insecticidal activity against Amphimallon majalis (European chafer) assessed as mortality after 10 days | 2010 | Pest management science, Jan, Volume: 66, Issue:1 | Variation in the laboratory susceptibility of turf-infesting white grubs (Coleoptera: Scarabaeidae) to biological, biorational and chemical control products. |
| AID1101022 | Displacement of [3H]IMI from nicotinic acetylcholine receptor in Aphis craccivora (cowpea aphid) whole body membrane after 90 min by filter binding assay | 2000 | Journal of neurochemistry, Sep, Volume: 75, Issue:3 | Insect nicotinic acetylcholine receptor: conserved neonicotinoid specificity of [(3)H]imidacloprid binding site. |
| AID1112857 | Insecticidal activity against second generation Blissus occiduus in buffalograss under field condition assessed as reduction in number at 89.7 kg/ha measured 55 days after treatment | 2013 | Pest management science, Feb, Volume: 69, Issue:2 | Effect of distribution and concentration of topically applied neonicotinoid insecticides in buffalograss, Buchloe dactyloides, leaf tissues on the differential mortality of Blissus occiduus under field conditions. |
| AID1112854 | Drug level in Urochloa mutica (buffalo grass) measured per gram of fresh weight at 19.1 kg/ha measured 3 days after treatment | 2013 | Pest management science, Feb, Volume: 69, Issue:2 | Effect of distribution and concentration of topically applied neonicotinoid insecticides in buffalograss, Buchloe dactyloides, leaf tissues on the differential mortality of Blissus occiduus under field conditions. |
| AID1104229 | Inhibition of Ceutorhynchus obstrictus preimaginal development in Brassica napus L. Ryder pods of plant developed from compound treated seeds assessed as decrease in number of second-instar larvae at 600 g/L FS by microscopic analysis | 2009 | Pest management science, Dec, Volume: 65, Issue:12 | Responses of the cabbage seedpod weevil, Ceutorhynchus obstrictus (Marsham) (Coleoptera: Curculionidae), to seed treatments of canola (Brassica napus L.) with the neonicotinoid compounds clothianidin and imidacloprid. |
| AID1111082 | Insecticidal activity against Anomala orientalis assessed as mortality after 20 days | 2010 | Pest management science, Jan, Volume: 66, Issue:1 | Variation in the laboratory susceptibility of turf-infesting white grubs (Coleoptera: Scarabaeidae) to biological, biorational and chemical control products. |
| AID1082242 | Phytotoxicity against Gossypium hirsutum (cotton) seedlings assessed as lesions at 50 to 100 ppm after 9 days | 2011 | Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9 | Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition. |
| AID1104228 | Inhibition of Ceutorhynchus obstrictus preimaginal development in Brassica napus L. Ryder pods of plant developed from compound treated seeds assessed as decrease in number of third-instar larvae at 600 g/L FS by microscopic analysis | 2009 | Pest management science, Dec, Volume: 65, Issue:12 | Responses of the cabbage seedpod weevil, Ceutorhynchus obstrictus (Marsham) (Coleoptera: Curculionidae), to seed treatments of canola (Brassica napus L.) with the neonicotinoid compounds clothianidin and imidacloprid. |
| AID1101020 | Displacement of [3H]IMI from nicotinic acetylcholine receptor in Drosophila melanogaster head membrane after 90 min by filter binding assay | 2000 | Journal of neurochemistry, Sep, Volume: 75, Issue:3 | Insect nicotinic acetylcholine receptor: conserved neonicotinoid specificity of [(3)H]imidacloprid binding site. |
| AID1082237 | Inhibition of xanthine oxidase | 2011 | Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9 | Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition. |
| AID1080612 | Insecticidal activity against adult Aphis gossypii (cotton aphid) in cucumber cotyledons assessed as mortality at 500 ppm treated for 5 secs before adult infestation measured after 72 hr | 2009 | Journal of agricultural and food chemistry, Mar-25, Volume: 57, Issue:6 | Neonicotinoid substituents forming a water bridge at the nicotinic acetylcholine receptor. |
| AID1111950 | Insecticidal activity against imidacloprid-resistant Aphis gossypii (cotton aphid) in cotton leaves assessed as reduction in body weight at LC20 concentration measured after 72 hr by dipping method (Rvb = 0.40 +/- 0.0002 mg/aphid) | 2011 | Pest management science, Dec, Volume: 67, Issue:12 | Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii. |
| AID1112210 | Insecticidal activity against Popillia japonica at 500 g/kg WG assessed as reduction in leaf damage measured after 35 days by irrigation injection method (Rvb = 50.97 +/- 7.2 %) | 2012 | Pest management science, Apr, Volume: 68, Issue:4 | Soil application of neonicotinoid insecticides for control of insect pests in wine grape vineyards. |
| AID1112216 | Insecticidal activity against Popillia japonica at 500 g/kg WG assessed as moribund behaviour measured after 10 to 19 days by irrigation injection method | 2012 | Pest management science, Apr, Volume: 68, Issue:4 | Soil application of neonicotinoid insecticides for control of insect pests in wine grape vineyards. |
| AID1104230 | Inhibition of Ceutorhynchus obstrictus preimaginal development in Brassica napus L. Ryder pods of plant developed from compound treated seeds assessed as effect on number of first-instar larvae at 600 g/L FS by microscopic analysis | 2009 | Pest management science, Dec, Volume: 65, Issue:12 | Responses of the cabbage seedpod weevil, Ceutorhynchus obstrictus (Marsham) (Coleoptera: Curculionidae), to seed treatments of canola (Brassica napus L.) with the neonicotinoid compounds clothianidin and imidacloprid. |
| AID1112864 | Insecticidal activity against second generation Blissus occiduus in buffalograss under field condition assessed as reduction in number at 89.7 kg/ha measured 7 days after treatment | 2013 | Pest management science, Feb, Volume: 69, Issue:2 | Effect of distribution and concentration of topically applied neonicotinoid insecticides in buffalograss, Buchloe dactyloides, leaf tissues on the differential mortality of Blissus occiduus under field conditions. |
| AID1111085 | Insecticidal activity against Amphimallon majalis (European chafer) assessed as mortality after 20 days | 2010 | Pest management science, Jan, Volume: 66, Issue:1 | Variation in the laboratory susceptibility of turf-infesting white grubs (Coleoptera: Scarabaeidae) to biological, biorational and chemical control products. |
| AID1082233 | Inhibition of Agaricus bisporus (mushroom) tyrosinase at IC50 concentration | 2011 | Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9 | Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition. |
| AID1101023 | Displacement of [3H]IMI from nicotinic acetylcholine receptor in Myzus persicae (green peach aphid) whole body membrane after 90 min by filter binding assay | 2000 | Journal of neurochemistry, Sep, Volume: 75, Issue:3 | Insect nicotinic acetylcholine receptor: conserved neonicotinoid specificity of [(3)H]imidacloprid binding site. |
| AID1111078 | Insecticidal activity against Maladera castanea assessed as mortality after 20 days | 2010 | Pest management science, Jan, Volume: 66, Issue:1 | Variation in the laboratory susceptibility of turf-infesting white grubs (Coleoptera: Scarabaeidae) to biological, biorational and chemical control products. |
| AID1112207 | Insecticidal activity against Paralobesia viteana infested grapevine assessed as reduction in clusters infested with moth by early-season irrigation injection method (Rvb = 34.3 +/- 4.4 %) | 2012 | Pest management science, Apr, Volume: 68, Issue:4 | Soil application of neonicotinoid insecticides for control of insect pests in wine grape vineyards. |
| AID1112844 | Drug level in Urochloa mutica (buffalo grass) measured per gram of fresh weight at 19.1 kg/ha measured 28 days after treatment | 2013 | Pest management science, Feb, Volume: 69, Issue:2 | Effect of distribution and concentration of topically applied neonicotinoid insecticides in buffalograss, Buchloe dactyloides, leaf tissues on the differential mortality of Blissus occiduus under field conditions. |
| AID1111079 | Insecticidal activity against Maladera castanea assessed as mortality after 30 days | 2010 | Pest management science, Jan, Volume: 66, Issue:1 | Variation in the laboratory susceptibility of turf-infesting white grubs (Coleoptera: Scarabaeidae) to biological, biorational and chemical control products. |
| AID1101021 | Displacement of [3H]IMI from nicotinic acetylcholine receptor in Musca domestica (house fly) head membrane after 90 min by filter binding assay | 2000 | Journal of neurochemistry, Sep, Volume: 75, Issue:3 | Insect nicotinic acetylcholine receptor: conserved neonicotinoid specificity of [(3)H]imidacloprid binding site. |
| AID1111948 | Insecticidal activity against imidacloprid-resistant Aphis gossypii (cotton aphid) in cotton leaves assessed as longevity at LC20 concentration | 2011 | Pest management science, Dec, Volume: 67, Issue:12 | Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii. |
| AID1111952 | Insecticidal activity against imidacloprid-resistant Aphis gossypii (cotton aphid) in cotton leaves assessed as mortality measured after 72 hr by dipping method | 2011 | Pest management science, Dec, Volume: 67, Issue:12 | Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii. |
| AID1111077 | Insecticidal activity against Popillia japonica assessed as mortality after 10 days | 2010 | Pest management science, Jan, Volume: 66, Issue:1 | Variation in the laboratory susceptibility of turf-infesting white grubs (Coleoptera: Scarabaeidae) to biological, biorational and chemical control products. |
| AID1112851 | Drug level in Urochloa mutica (buffalo grass) measured per gram of fresh weight at 19.1 kg/ha measured 7 days after treatment | 2013 | Pest management science, Feb, Volume: 69, Issue:2 | Effect of distribution and concentration of topically applied neonicotinoid insecticides in buffalograss, Buchloe dactyloides, leaf tissues on the differential mortality of Blissus occiduus under field conditions. |
| AID1111076 | Insecticidal activity against Popillia japonica assessed as mortality after 20 days | 2010 | Pest management science, Jan, Volume: 66, Issue:1 | Variation in the laboratory susceptibility of turf-infesting white grubs (Coleoptera: Scarabaeidae) to biological, biorational and chemical control products. |
| AID1112849 | Drug level in Urochloa mutica (buffalo grass) measured per gram of fresh weight at 19.1 kg/ha measured 14 days after treatment | 2013 | Pest management science, Feb, Volume: 69, Issue:2 | Effect of distribution and concentration of topically applied neonicotinoid insecticides in buffalograss, Buchloe dactyloides, leaf tissues on the differential mortality of Blissus occiduus under field conditions. |
| AID1112902 | Displacement of [3H]IMD from nAChR in Myzus persicae 4106A (green peach aphid) membrane after 70 min | 2013 | Pest management science, May, Volume: 69, Issue:5 | Investigating the mode of action of sulfoxaflor: a fourth-generation neonicotinoid. |
| AID1111951 | Insecticidal activity against imidacloprid-resistant Aphis gossypii (cotton aphid) in cotton leaves assessed as reduction in body weight at LC20 concentration measured after 48 hr by dipping method (Rvb = 0.36 +/- 0.0006 mg/aphid) | 2011 | Pest management science, Dec, Volume: 67, Issue:12 | Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii. |
| AID1111080 | Insecticidal activity against Maladera castanea assessed as mortality after 10 days | 2010 | Pest management science, Jan, Volume: 66, Issue:1 | Variation in the laboratory susceptibility of turf-infesting white grubs (Coleoptera: Scarabaeidae) to biological, biorational and chemical control products. |
| AID1082239 | Inhibition of Agaricus bisporus (mushroom) tyrosinase | 2011 | Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9 | Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition. |
| AID1111075 | Insecticidal activity against Popillia japonica assessed as mortality after 30 days | 2010 | Pest management science, Jan, Volume: 66, Issue:1 | Variation in the laboratory susceptibility of turf-infesting white grubs (Coleoptera: Scarabaeidae) to biological, biorational and chemical control products. |
| AID1112867 | Insecticidal activity against second generation Blissus occiduus in buffalograss under field condition assessed as reduction in number at 89.7 kg/ha measured 3 days after treatment | 2013 | Pest management science, Feb, Volume: 69, Issue:2 | Effect of distribution and concentration of topically applied neonicotinoid insecticides in buffalograss, Buchloe dactyloides, leaf tissues on the differential mortality of Blissus occiduus under field conditions. |
| AID1104205 | Inhibition of Contarinia nasturtii larval development in Brassica oleracea L. var italica plant developed from compound pretreated seeds at 4.5 g AI per 100 g seed measured at 4-5 weeks after planting | 2009 | Pest management science, Dec, Volume: 65, Issue:12 | Responses of the cabbage seedpod weevil, Ceutorhynchus obstrictus (Marsham) (Coleoptera: Curculionidae), to seed treatments of canola (Brassica napus L.) with the neonicotinoid compounds clothianidin and imidacloprid. |
| AID318725 | Displacement of [3H]ACE from Aplysia AChBP expressed in HEK293S cells by scintillation proximity assay | 2007 | Proceedings of the National Academy of Sciences of the United States of America, May-22, Volume: 104, Issue:21 | Mapping the elusive neonicotinoid binding site. |
| AID1112208 | Insecticidal activity against Paralobesia viteana infested grapevine assessed as reduction in clusters infested with moth by mid-season irrigation injection method (Rvb = 11 +/- 1.9 %) | 2012 | Pest management science, Apr, Volume: 68, Issue:4 | Soil application of neonicotinoid insecticides for control of insect pests in wine grape vineyards. |
| AID1082240 | Phytotoxicity against Vitis vinifera seedlings assessed as lesions at 50 to 100 ppm after 9 days | 2011 | Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9 | Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition. |
| AID1104217 | Inhibition of emergence of new-generation Ceutorhynchus obstrictus adults from soil harboring Brassica napus L. Ryder plant developed from compound treated seeds at 600 g/L FS measured for 5 weeks relative to lindane | 2009 | Pest management science, Dec, Volume: 65, Issue:12 | Responses of the cabbage seedpod weevil, Ceutorhynchus obstrictus (Marsham) (Coleoptera: Curculionidae), to seed treatments of canola (Brassica napus L.) with the neonicotinoid compounds clothianidin and imidacloprid. |
| AID1112843 | Insecticidal activity against first generation Blissus occiduus in buffalograss under field condition assessed as reduction in number at 89.7 kg/ha measured 3 days after treatment | 2013 | Pest management science, Feb, Volume: 69, Issue:2 | Effect of distribution and concentration of topically applied neonicotinoid insecticides in buffalograss, Buchloe dactyloides, leaf tissues on the differential mortality of Blissus occiduus under field conditions. |
| AID1112837 | Insecticidal activity against first generation Blissus occiduus in buffalograss under field condition assessed as reduction in number at 89.7 kg/ha measured 106 days after treatment | 2013 | Pest management science, Feb, Volume: 69, Issue:2 | Effect of distribution and concentration of topically applied neonicotinoid insecticides in buffalograss, Buchloe dactyloides, leaf tissues on the differential mortality of Blissus occiduus under field conditions. |
| AID1101018 | Competitive inhibition of nicotinic acetylcholine receptor in Myzus persicae (green peach aphid) whole body membrane using [3H]IMI as substrate incubated for 5 min prior to substrate addition measured after 90 min by Sctachard plot analysis | 2000 | Journal of neurochemistry, Sep, Volume: 75, Issue:3 | Insect nicotinic acetylcholine receptor: conserved neonicotinoid specificity of [(3)H]imidacloprid binding site. |
| AID1082241 | Phytotoxicity against Zea mays (maize) seedlings assessed as lesions at 50 to 100 ppm after 9 days | 2011 | Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9 | Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition. |
| AID1112840 | Insecticidal activity against first generation Blissus occiduus in buffalograss under field condition assessed as reduction in number at 89.7 kg/ha measured 8 days after treatment | 2013 | Pest management science, Feb, Volume: 69, Issue:2 | Effect of distribution and concentration of topically applied neonicotinoid insecticides in buffalograss, Buchloe dactyloides, leaf tissues on the differential mortality of Blissus occiduus under field conditions. |
| AID1112898 | Resistance index, ratio of LC50 for neonicotinoid-resistant Myzus persicae FRC-P (green peach aphid) to LC50 for Myzus persicae 4106A | 2013 | Pest management science, May, Volume: 69, Issue:5 | Investigating the mode of action of sulfoxaflor: a fourth-generation neonicotinoid. |
| AID1111956 | Insecticidal activity against Aphis gossypii SS (cotton aphid) in cotton leaves assessed as mortality measured after 48 hr by dipping method | 2011 | Pest management science, Dec, Volume: 67, Issue:12 | Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii. |
| AID1112217 | Insecticidal activity against Popillia japonica at 500 g/kg WG assessed as moribund behaviour measured after 3 days by irrigation injection method | 2012 | Pest management science, Apr, Volume: 68, Issue:4 | Soil application of neonicotinoid insecticides for control of insect pests in wine grape vineyards. |
| AID1082244 | Phytotoxicity against Glycine max (soybean) seedlings assessed as lesions in unfoliolate leaves at 100 ppm after 9 days | 2011 | Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9 | Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 28 (6.97) | 29.6817 |
| 2010's | 248 (61.69) | 24.3611 |
| 2020's | 126 (31.34) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (39.82) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (0.25%) | 5.53% |
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 4 (1.01%) | 6.00% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 1 (0.25%) | 4.05% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 389 (98.48%) | 84.16% |
| Other | 10 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||