Page last updated: 2024-08-24

triazoles and gs-458967

triazoles has been researched along with gs-458967 in 32 studies

Research

Studies (32)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	29 (90.63)	24.3611
2020's	3 (9.38)	2.80

Authors

Authors	Studies
Belardinelli, L; Crumb, W; Dhalla, AK; El-Bizri, N; Hirakawa, R; Hu, L; Karpinski, S; Koltun, D; Li, CH; Li, XJ; Liu, G; Rajamani, S; Shryock, JC; Smith-Maxwell, C; Wang, WQ; Wu, L; Yao, L; Zablocki, J	1
Antzelevitch, C; Belardinelli, L; Sicouri, S	1
Belardinelli, L; Ghukasyan, H; Karagueuzian, HS; Madahian, S; Pezhouman, A; Qu, Z; Stepanyan, H	1
Belardinelli, L; Dhalla, AK; Fernandes, S; Hoyer, K; Liu, G; Rajamani, S; Wang, WQ	1
Anderson, LL; Bush, WS; Frankel, WN; George, AL; Hawkins, NA; Kearney, JA; Nath, RD; Petersohn, AA; Rajamani, S; Thompson, CH; Vanoye, CG	1
Batatinha, JA; Belardinelli, L; Bonatti, R; Machado, AD; Nearing, BD; Silva, AF; Sobrado, LF; Varone, BB; Verrier, RL	1
Belardinelli, L; Chen-Izu, Y; Clancy, CE; Giles, WR; Horvath, B; Rajamani, S; Song, Y; Yang, PC	1
Antzelevitch, C; Belardinelli, L; Burashnikov, A; Di Diego, JM; Goodrow, RJ	1
Alves Bento, AS; Bacic, D; Belardinelli, L; Fuller, H; Justo, FA; Nearing, BD; Rajamani, S; Saran Carneiro, J; Verrier, RL	1
Bapat, A; Cao, H; Eskandari, A; Karagueuzian, HS; Ko, CY; Nguyen, T; Nivala, M; Pezhouman, A; Qu, Z; Singh, N; Song, Z; Weiss, JN	1
Bacic, D; Belardinelli, L; Bento, AS; Carneiro, JS; Nearing, BD; Rajamani, S; Verrier, RL	1
Belardinelli, L; Chi, L; Dhalla, AK; Hirakawa, R; Ling, H; Rajamani, S; Zeng, A	1
Avila, B; Belardinelli, L; Dhalla, AK; Elzein, E; Jiang, RH; Kalla, R; Kobayashi, T; Koltun, DO; Li, X; Mollova, N; Notte, GT; Parkhill, EQ; Perry, TD; Rajamani, S; Smith-Maxwell, C; Stafford, B; Tang, J; Wang, WQ; Zablocki, JA	1
George, AL; Potet, F; Vanoye, CG	1
Belardinelli, L; Clancy, CE; El-Bizri, N; Giles, WR; Rajamani, S; Romero, L; Yang, PC	1
Azam, MA; Kusha, M; Labos, C; Lai, PF; Massé, S; Nair, GK; Nanthakumar, K; Tan, NS; Zamiri, N	1
Belardinelli, L; Bezzina, CR; Casini, S; Hoekstra, M; Mengarelli, I; Portero, V; Rajamani, S; Remme, CA; Veldkamp, MW; Verkerk, AO; Wilde, AAM	1
Anderson, LL; George, AL; Hawkins, NA; Kearney, JA; Thompson, CH	1
Belardinelli, L; El-Bizri, N; Li, CH; Liu, GX; Rajamani, S	1
Chen, YH; Fei, YD; Hou, JW; Li, W; Li, YG; Wang, Q; Wang, YP	1
Belardinelli, L; Cerbai, E; Coppini, R; Ferrantini, C; Gentile, F; Matucci, R; Mazzoni, L; Mugelli, A; Olivotto, I; Palandri, C; Pioner, JM; Poggesi, C; Rossi, A; Tesi, C; Tosi, B	1
Beekman, HDM; Belardinelli, L; Bossu, A; de Bakker, JMT; Dunnink, A; Houtman, MJC; Meijborg, VMF; Mollova, N; Rajamani, S; van der Heyden, MAG; Varkevisser, R; Vos, MA	1
Baker, EM; George, AL; Hawkins, NA; Kearney, JA; Meisler, MH; Patel, MK; Thompson, CH; Wagnon, JL; Wengert, ER	1
Alberola, A; Arias-Mutis, O; Chorro, FJ; Del Canto, I; Genovés, P; Parra, G; Santamaría, L; Soler, C; Such, L; Such-Miquel, L; Tormos, Á; Zarzoso, M	1
Huang, Q; Jiang, Y; Jin, X; Li, P; Lu, Y; Pan, Z; Shi, L; Su, W; Sun, Y; Wang, Z; Xue, G; Yang, B; Yuan, Y; Zhan, L; Zhang, Y; Zhao, Y; Zhu, H; Zhuang, Y	1
Abou Tayoun, A; Goldberg, EM; Zaman, T	1
Hamaguchi, S; Hiiro, H; Irie, M; Namekata, I; Tanaka, H	1
Barbieri, R; Bertelli, S; Gavazzo, P; Pusch, M	1
Bossu, A; van Weperen, VYH; Vos, MA	1
Cummins, TR; Mason, ER	1
Burridge, PW; Egecioglu, DE; George, AL; Potet, F	1
Abi-Gerges, N; Cotta, T; Espinoza, A; Geft, V; Ghetti, A; Hernandez, E; Indersmitten, T; Macias, A; Mai, C; Miller, PE; Miron, Y; Nguyen, W; Page, G; Rasoul, L; Stafford, A; Sweat, K; Ton, AT; Truong, K; Wong, T	1

Reviews

1 review(s) available for triazoles and gs-458967

Article	Year
Point of View: Electrophysiological Endpoints Differ When Comparing the Mode of Action of Highly Successful Anti-arrhythmic Drugs in the CAVB Dog Model With TdP. Journal of cardiovascular pharmacology, 2019, Volume: 74, Issue:6 Topics: Action Potentials; Aniline Compounds; Animals; Anti-Arrhythmia Agents; Atrioventricular Block; Chronic Disease; Disease Models, Animal; Dogs; Electrophysiologic Techniques, Cardiac; Endpoint Determination; Flunarizine; Heart Rate; Phenyl Ethers; Pyridines; Time Factors; Torsades de Pointes; Triazoles; Verapamil	2019

Article

Year

Point of View: Electrophysiological Endpoints Differ When Comparing the Mode of Action of Highly Successful Anti-arrhythmic Drugs in the CAVB Dog Model With TdP.

Journal of cardiovascular pharmacology, 2019, Volume: 74, Issue:6

Topics: Action Potentials; Aniline Compounds; Animals; Anti-Arrhythmia Agents; Atrioventricular Block; Chronic Disease; Disease Models, Animal; Dogs; Electrophysiologic Techniques, Cardiac; Endpoint Determination; Flunarizine; Heart Rate; Phenyl Ethers; Pyridines; Time Factors; Torsades de Pointes; Triazoles; Verapamil

2019

Other Studies

31 other study(ies) available for triazoles and gs-458967

Article	Year
A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias. The Journal of pharmacology and experimental therapeutics, 2013, Volume: 344, Issue:1 Topics: Acetanilides; Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiotonic Agents; Cnidarian Venoms; Female; Flecainide; Heart Conduction System; Long QT Syndrome; Mutation; Myocardial Ischemia; Myocytes, Cardiac; Patch-Clamp Techniques; Piperazines; Potassium Channel Blockers; Pyridines; Quaternary Ammonium Compounds; Rabbits; Ranolazine; Sodium Channel Blockers; Triazoles	2013
Antiarrhythmic effects of the highly selective late sodium channel current blocker GS-458967. Heart rhythm, 2013, Volume: 10, Issue:7 Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Disease Models, Animal; Dogs; Electrophysiological Phenomena; Heart Conduction System; Membrane Potentials; Pyridines; Sodium Channel Blockers; Triazoles	2013
Selective inhibition of late sodium current suppresses ventricular tachycardia and fibrillation in intact rat hearts. Heart rhythm, 2014, Volume: 11, Issue:3 Topics: Aconitine; Action Potentials; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Male; Pyridines; Rats; Rats, Inbred F344; Tachycardia, Ventricular; Triazoles; Ventricular Fibrillation	2014
Selective inhibition of the late sodium current has no adverse effect on electrophysiological or contractile function of the normal heart. Journal of cardiovascular pharmacology, 2014, Volume: 63, Issue:6 Topics: Animals; Electrophysiological Phenomena; Female; Heart; Heart Rate; Male; Myocardial Contraction; Organ Culture Techniques; Pyridines; Rabbits; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Triazoles	2014
Antiepileptic activity of preferential inhibitors of persistent sodium current. Epilepsia, 2014, Volume: 55, Issue:8 Topics: Acetanilides; Animals; Anticonvulsants; Cells, Cultured; Female; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; NAV1.2 Voltage-Gated Sodium Channel; Neurons; Piperazines; Pyridines; Ranolazine; Seizures; Sodium Channel Blockers; Triazoles	2014
Selective late sodium current blockade with GS-458967 markedly reduces ischemia-induced atrial and ventricular repolarization alternans and ECG heterogeneity. Heart rhythm, 2014, Volume: 11, Issue:10 Topics: Animals; Atrial Fibrillation; Coronary Stenosis; Dose-Response Relationship, Drug; Electrocardiography; Heart Conduction System; Injections, Intravenous; Male; Pyridines; Sodium Channel Blockers; Swine; Time Factors; Treatment Outcome; Triazoles; Ventricular Fibrillation	2014
A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current. The Journal of physiology, 2015, Mar-15, Volume: 593, Issue:6 Topics: Action Potentials; Animals; Female; Guinea Pigs; Heart Ventricles; Male; Models, Neurological; Myocytes, Cardiac; Protein Binding; Pyridines; Sodium Channel Blockers; Sodium Channels; Triazoles; Ventricular Function	2015
Atria are More Sensitive Than Ventricles to GS-458967-Induced Inhibition of Late Sodium Current. Journal of cardiovascular pharmacology and therapeutics, 2015, Volume: 20, Issue:5 Topics: Animals; Dogs; Electrophysiological Phenomena; Heart Atria; Heart Ventricles; Pyridines; Sodium Channel Blockers; Sodium Channels; Triazoles	2015
Selective late INa inhibition by GS-458967 exerts parallel suppression of catecholamine-induced hemodynamically significant ventricular tachycardia and T-wave alternans in an intact porcine model. Heart rhythm, 2015, Volume: 12, Issue:12 Topics: Animals; Blood Pressure; Disease Models, Animal; Electrocardiography; Epinephrine; Heart Rate; Pyridines; Swine; Tachycardia, Ventricular; Triazoles	2015
Molecular Basis of Hypokalemia-Induced Ventricular Fibrillation. Circulation, 2015, Oct-20, Volume: 132, Issue:16 Topics: Action Potentials; Animals; Benzylamines; Computer Simulation; Hypokalemia; Male; Phenethylamines; Pyridines; Rabbits; Rats; Rats, Inbred F344; Sodium-Potassium-Exchanging ATPase; Sulfonamides; Triazoles; Ventricular Fibrillation	2015
The Selective Cardiac Late Sodium Current Inhibitor GS-458967 Suppresses Autonomically Triggered Atrial Fibrillation in an Intact Porcine Model. Journal of cardiovascular electrophysiology, 2015, Volume: 26, Issue:12 Topics: Acetylcholine; Animals; Anti-Arrhythmia Agents; Arterial Pressure; Atrial Fibrillation; Autonomic Nervous System Diseases; Electric Stimulation; Electrocardiography; Epinephrine; Heart Rate; Male; Pyridines; Sodium Channel Blockers; Sus scrofa; Swine; Triazoles	2015
Inhibition of late Na+ current, a novel target to improve diastolic function and electrical abnormalities in Dahl salt-sensitive rats. American journal of physiology. Heart and circulatory physiology, 2016, 05-15, Volume: 310, Issue:10 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Dose-Response Relationship, Drug; Heart Conduction System; Heart Failure; Heart Rate; Hypertrophy, Left Ventricular; Male; Myocardial Contraction; Myocytes, Cardiac; Oxidative Stress; Pyridines; Rats, Inbred Dahl; Sodium Channel Blockers; Sodium Channels; Sodium Chloride, Dietary; Time Factors; Triazoles; Ventricular Dysfunction, Left; Ventricular Function, Left	2016
Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late INai) of the cardiac NaV 1.5 channel with improved efficacy and potency relative to ranolazine. Bioorganic & medicinal chemistry letters, 2016, 07-01, Volume: 26, Issue:13 Topics: Animals; Caco-2 Cells; Dose-Response Relationship, Drug; Drug Discovery; Ether-A-Go-Go Potassium Channels; Heart; Humans; Macaca fascicularis; Microsomes, Liver; Molecular Structure; NAV1.5 Voltage-Gated Sodium Channel; Pyridines; Rabbits; Ranolazine; Rats; Sodium Channel Blockers; Structure-Activity Relationship; Triazoles	2016
Use-Dependent Block of Human Cardiac Sodium Channels by GS967. Molecular pharmacology, 2016, Volume: 90, Issue:1 Topics: Anesthetics; Humans; Ion Channel Gating; Lidocaine; Myocardium; Pyridines; Ranolazine; Sodium Channel Blockers; Sodium Channels; Triazoles	2016
A computational model predicts adjunctive pharmacotherapy for cardiac safety via selective inhibition of the late cardiac Na current. Journal of molecular and cellular cardiology, 2016, Volume: 99 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cell Survival; Computer Simulation; Drug-Related Side Effects and Adverse Reactions; Electrocardiography; Heart; Humans; Models, Biological; Myocardium; Myocytes, Cardiac; Patch-Clamp Techniques; Pyridines; Rabbits; Sodium Channels; Triazoles	2016
Effects of Late Sodium Current Blockade on Ventricular Refibrillation in a Rabbit Model. Circulation. Arrhythmia and electrophysiology, 2017, Volume: 10, Issue:3 Topics: Animals; Calcium; Calcium Channels; Disease Models, Animal; Electric Countershock; Heart Arrest; Logistic Models; Pyridines; Rabbits; Random Allocation; Ranolazine; Reference Values; Sodium Channel Blockers; Sodium Channels; Statistics, Nonparametric; Triazoles; Ventricular Fibrillation	2017
Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 in murine Scn5a-1798insD+/- and human SCN5A-1795insD+/- iPSC-derived cardiomyocytes. Cardiovascular research, 2017, Jun-01, Volume: 113, Issue:7 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cell Line; Epicardial Mapping; Female; Genetic Predisposition to Disease; Heart Rate; Induced Pluripotent Stem Cells; Isolated Heart Preparation; Kinetics; Long QT Syndrome; Male; Mice, Transgenic; Mutation; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Phenotype; Pyridines; Triazoles; Voltage-Gated Sodium Channel Blockers	2017
Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome. Scientific reports, 2017, 05-10, Volume: 7, Issue:1 Topics: Action Potentials; Animals; Epilepsies, Myoclonic; Ion Channel Gating; Mice, Inbred C57BL; Mice, Knockout; NAV1.1 Voltage-Gated Sodium Channel; NAV1.6 Voltage-Gated Sodium Channel; Neurons; Pyramidal Cells; Pyridines; Seizures; Survival Analysis; Triazoles	2017
Selective inhibition of physiological late Na American journal of physiology. Heart and circulatory physiology, 2018, 02-01, Volume: 314, Issue:2 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Disease Models, Animal; Female; Heart Rate; Heart Ventricles; In Vitro Techniques; Isolated Heart Preparation; Kinetics; Myocytes, Cardiac; Piperidines; Pyridines; Rabbits; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Triazoles	2018
I Journal of physiology and biochemistry, 2018, Volume: 74, Issue:1 Topics: 4-Aminopyridine; Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Electrophysiological Phenomena; Heart Atria; Kinetics; Myocytes, Cardiac; Nifedipine; Potassium Channel Blockers; Pyridines; Rabbits; Single-Cell Analysis; Sodium Channel Blockers; Sodium Channels; Triazoles	2018
Late sodium current inhibitors to treat exercise-induced obstruction in hypertrophic cardiomyopathy: an in vitro study in human myocardium. British journal of pharmacology, 2018, Volume: 175, Issue:13 Topics: Adrenergic beta-Antagonists; Cardiomyopathy, Hypertrophic; Cohort Studies; Dose-Response Relationship, Drug; Exercise; Female; Humans; Male; Middle Aged; Myocardium; Pyridines; Ranolazine; Sodium; Sodium Channel Blockers; Triazoles	2018
Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia. British journal of pharmacology, 2018, Volume: 175, Issue:12 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Dose-Response Relationship, Drug; Myocytes, Cardiac; Phenethylamines; Pyridines; Sulfonamides; Torsades de Pointes; Triazoles	2018
The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy. Epilepsia, 2018, Volume: 59, Issue:6 Topics: Action Potentials; Animals; Anticonvulsants; Brain Diseases; Disease Models, Animal; Drug Administration Schedule; Electroshock; Epilepsy; Female; Hippocampus; Humans; Male; Mice; Mice, Transgenic; Mutation; NAV1.6 Voltage-Gated Sodium Channel; Neurons; Off-Label Use; Phenytoin; Pyridines; Triazoles	2018
Effects of the Inhibition of Late Sodium Current by GS967 on Stretch-Induced Changes in Cardiac Electrophysiology. Cardiovascular drugs and therapy, 2018, Volume: 32, Issue:5 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Disease Models, Animal; Dose-Response Relationship, Drug; Isolated Heart Preparation; Male; Mechanoreceptors; Mechanotransduction, Cellular; Myocytes, Cardiac; Pyridines; Rabbits; Refractory Period, Electrophysiological; Sodium Channel Blockers; Sodium Channels; Time Factors; Triazoles; Ventricular Fibrillation	2018
Increase of late sodium current contributes to enhanced susceptibility to atrial fibrillation in diabetic mice. European journal of pharmacology, 2019, Aug-15, Volume: 857 Topics: Action Potentials; Animals; Atrial Fibrillation; Diabetes Mellitus, Experimental; Electrophysiological Phenomena; Male; Mice; Mice, Inbred C57BL; Pyridines; Sodium; Sodium Channel Blockers; Triazoles	2019
A single-center SCN8A-related epilepsy cohort: clinical, genetic, and physiologic characterization. Annals of clinical and translational neurology, 2019, Volume: 6, Issue:8 Topics: Cell Culture Techniques; Child; Cohort Studies; Epilepsy; Female; HEK293 Cells; Humans; Infant; Infant, Newborn; Male; Mutation; NAV1.6 Voltage-Gated Sodium Channel; Oxcarbazepine; Pyridines; Seizures; Sodium Channels; Triazoles	2019
Involvement of the persistent Na Journal of pharmacological sciences, 2019, Volume: 141, Issue:1 Topics: Action Potentials; Animals; Atrial Fibrillation; Cells, Cultured; Diastole; Guinea Pigs; Lidocaine; Male; Membrane Potentials; Myocytes, Cardiac; Pulmonary Veins; Pyridines; Sodium; Tetrodotoxin; Triazoles	2019
Late sodium current blocker GS967 inhibits persistent currents induced by familial hemiplegic migraine type 3 mutations of the SCN1A gene. The journal of headache and pain, 2019, Nov-15, Volume: 20, Issue:1 Topics: Action Potentials; Epilepsy; HEK293 Cells; Humans; Migraine Disorders; Migraine with Aura; Mutation; NAV1.1 Voltage-Gated Sodium Channel; Neurons; Pyridines; Sodium; Triazoles	2019
Differential Inhibition of Human Nav1.2 Resurgent and Persistent Sodium Currents by Cannabidiol and GS967. International journal of molecular sciences, 2020, Apr-01, Volume: 21, Issue:7 Topics: Action Potentials; Animals; Anticonvulsants; Cannabidiol; Epilepsy; HEK293 Cells; Humans; Ion Channel Gating; Mice; Mutation; NAV1.2 Voltage-Gated Sodium Channel; Neurons; Protein Isoforms; Pyridines; Triazoles	2020
GS-967 and Eleclazine Block Sodium Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Molecular pharmacology, 2020, Volume: 98, Issue:5 Topics: Action Potentials; Anti-Arrhythmia Agents; Cells, Cultured; Humans; Induced Pluripotent Stem Cells; Ion Channel Gating; Lidocaine; Myocytes, Cardiac; Oxazepines; Pyridines; Ranolazine; Sodium Channel Blockers; Sodium Channels; Triazoles	2020
Arrhythmogenic and antiarrhythmic actions of late sustained sodium current in the adult human heart. Scientific reports, 2021, 06-08, Volume: 11, Issue:1 Topics: Adult; Atrial Fibrillation; Calcium; Cnidarian Venoms; ERG1 Potassium Channel; Heart Atria; Humans; Membrane Potentials; Models, Cardiovascular; Myocytes, Cardiac; Piperidines; Pyridines; Ranolazine; Sodium; Triazoles	2021