triazoles has been researched along with gs-458967 in 32 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 29 (90.63) | 24.3611 |
2020's | 3 (9.38) | 2.80 |
Authors | Studies |
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Belardinelli, L; Crumb, W; Dhalla, AK; El-Bizri, N; Hirakawa, R; Hu, L; Karpinski, S; Koltun, D; Li, CH; Li, XJ; Liu, G; Rajamani, S; Shryock, JC; Smith-Maxwell, C; Wang, WQ; Wu, L; Yao, L; Zablocki, J | 1 |
Antzelevitch, C; Belardinelli, L; Sicouri, S | 1 |
Belardinelli, L; Ghukasyan, H; Karagueuzian, HS; Madahian, S; Pezhouman, A; Qu, Z; Stepanyan, H | 1 |
Belardinelli, L; Dhalla, AK; Fernandes, S; Hoyer, K; Liu, G; Rajamani, S; Wang, WQ | 1 |
Anderson, LL; Bush, WS; Frankel, WN; George, AL; Hawkins, NA; Kearney, JA; Nath, RD; Petersohn, AA; Rajamani, S; Thompson, CH; Vanoye, CG | 1 |
Batatinha, JA; Belardinelli, L; Bonatti, R; Machado, AD; Nearing, BD; Silva, AF; Sobrado, LF; Varone, BB; Verrier, RL | 1 |
Belardinelli, L; Chen-Izu, Y; Clancy, CE; Giles, WR; Horvath, B; Rajamani, S; Song, Y; Yang, PC | 1 |
Antzelevitch, C; Belardinelli, L; Burashnikov, A; Di Diego, JM; Goodrow, RJ | 1 |
Alves Bento, AS; Bacic, D; Belardinelli, L; Fuller, H; Justo, FA; Nearing, BD; Rajamani, S; Saran Carneiro, J; Verrier, RL | 1 |
Bapat, A; Cao, H; Eskandari, A; Karagueuzian, HS; Ko, CY; Nguyen, T; Nivala, M; Pezhouman, A; Qu, Z; Singh, N; Song, Z; Weiss, JN | 1 |
Bacic, D; Belardinelli, L; Bento, AS; Carneiro, JS; Nearing, BD; Rajamani, S; Verrier, RL | 1 |
Belardinelli, L; Chi, L; Dhalla, AK; Hirakawa, R; Ling, H; Rajamani, S; Zeng, A | 1 |
Avila, B; Belardinelli, L; Dhalla, AK; Elzein, E; Jiang, RH; Kalla, R; Kobayashi, T; Koltun, DO; Li, X; Mollova, N; Notte, GT; Parkhill, EQ; Perry, TD; Rajamani, S; Smith-Maxwell, C; Stafford, B; Tang, J; Wang, WQ; Zablocki, JA | 1 |
George, AL; Potet, F; Vanoye, CG | 1 |
Belardinelli, L; Clancy, CE; El-Bizri, N; Giles, WR; Rajamani, S; Romero, L; Yang, PC | 1 |
Azam, MA; Kusha, M; Labos, C; Lai, PF; Massé, S; Nair, GK; Nanthakumar, K; Tan, NS; Zamiri, N | 1 |
Belardinelli, L; Bezzina, CR; Casini, S; Hoekstra, M; Mengarelli, I; Portero, V; Rajamani, S; Remme, CA; Veldkamp, MW; Verkerk, AO; Wilde, AAM | 1 |
Anderson, LL; George, AL; Hawkins, NA; Kearney, JA; Thompson, CH | 1 |
Belardinelli, L; El-Bizri, N; Li, CH; Liu, GX; Rajamani, S | 1 |
Chen, YH; Fei, YD; Hou, JW; Li, W; Li, YG; Wang, Q; Wang, YP | 1 |
Belardinelli, L; Cerbai, E; Coppini, R; Ferrantini, C; Gentile, F; Matucci, R; Mazzoni, L; Mugelli, A; Olivotto, I; Palandri, C; Pioner, JM; Poggesi, C; Rossi, A; Tesi, C; Tosi, B | 1 |
Beekman, HDM; Belardinelli, L; Bossu, A; de Bakker, JMT; Dunnink, A; Houtman, MJC; Meijborg, VMF; Mollova, N; Rajamani, S; van der Heyden, MAG; Varkevisser, R; Vos, MA | 1 |
Baker, EM; George, AL; Hawkins, NA; Kearney, JA; Meisler, MH; Patel, MK; Thompson, CH; Wagnon, JL; Wengert, ER | 1 |
Alberola, A; Arias-Mutis, O; Chorro, FJ; Del Canto, I; Genovés, P; Parra, G; Santamaría, L; Soler, C; Such, L; Such-Miquel, L; Tormos, Á; Zarzoso, M | 1 |
Huang, Q; Jiang, Y; Jin, X; Li, P; Lu, Y; Pan, Z; Shi, L; Su, W; Sun, Y; Wang, Z; Xue, G; Yang, B; Yuan, Y; Zhan, L; Zhang, Y; Zhao, Y; Zhu, H; Zhuang, Y | 1 |
Abou Tayoun, A; Goldberg, EM; Zaman, T | 1 |
Hamaguchi, S; Hiiro, H; Irie, M; Namekata, I; Tanaka, H | 1 |
Barbieri, R; Bertelli, S; Gavazzo, P; Pusch, M | 1 |
Bossu, A; van Weperen, VYH; Vos, MA | 1 |
Cummins, TR; Mason, ER | 1 |
Burridge, PW; Egecioglu, DE; George, AL; Potet, F | 1 |
Abi-Gerges, N; Cotta, T; Espinoza, A; Geft, V; Ghetti, A; Hernandez, E; Indersmitten, T; Macias, A; Mai, C; Miller, PE; Miron, Y; Nguyen, W; Page, G; Rasoul, L; Stafford, A; Sweat, K; Ton, AT; Truong, K; Wong, T | 1 |
1 review(s) available for triazoles and gs-458967
Article | Year |
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Point of View: Electrophysiological Endpoints Differ When Comparing the Mode of Action of Highly Successful Anti-arrhythmic Drugs in the CAVB Dog Model With TdP.
Topics: Action Potentials; Aniline Compounds; Animals; Anti-Arrhythmia Agents; Atrioventricular Block; Chronic Disease; Disease Models, Animal; Dogs; Electrophysiologic Techniques, Cardiac; Endpoint Determination; Flunarizine; Heart Rate; Phenyl Ethers; Pyridines; Time Factors; Torsades de Pointes; Triazoles; Verapamil | 2019 |
31 other study(ies) available for triazoles and gs-458967
Article | Year |
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A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias.
Topics: Acetanilides; Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiotonic Agents; Cnidarian Venoms; Female; Flecainide; Heart Conduction System; Long QT Syndrome; Mutation; Myocardial Ischemia; Myocytes, Cardiac; Patch-Clamp Techniques; Piperazines; Potassium Channel Blockers; Pyridines; Quaternary Ammonium Compounds; Rabbits; Ranolazine; Sodium Channel Blockers; Triazoles | 2013 |
Antiarrhythmic effects of the highly selective late sodium channel current blocker GS-458967.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Disease Models, Animal; Dogs; Electrophysiological Phenomena; Heart Conduction System; Membrane Potentials; Pyridines; Sodium Channel Blockers; Triazoles | 2013 |
Selective inhibition of late sodium current suppresses ventricular tachycardia and fibrillation in intact rat hearts.
Topics: Aconitine; Action Potentials; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Male; Pyridines; Rats; Rats, Inbred F344; Tachycardia, Ventricular; Triazoles; Ventricular Fibrillation | 2014 |
Selective inhibition of the late sodium current has no adverse effect on electrophysiological or contractile function of the normal heart.
Topics: Animals; Electrophysiological Phenomena; Female; Heart; Heart Rate; Male; Myocardial Contraction; Organ Culture Techniques; Pyridines; Rabbits; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Triazoles | 2014 |
Antiepileptic activity of preferential inhibitors of persistent sodium current.
Topics: Acetanilides; Animals; Anticonvulsants; Cells, Cultured; Female; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; NAV1.2 Voltage-Gated Sodium Channel; Neurons; Piperazines; Pyridines; Ranolazine; Seizures; Sodium Channel Blockers; Triazoles | 2014 |
Selective late sodium current blockade with GS-458967 markedly reduces ischemia-induced atrial and ventricular repolarization alternans and ECG heterogeneity.
Topics: Animals; Atrial Fibrillation; Coronary Stenosis; Dose-Response Relationship, Drug; Electrocardiography; Heart Conduction System; Injections, Intravenous; Male; Pyridines; Sodium Channel Blockers; Swine; Time Factors; Treatment Outcome; Triazoles; Ventricular Fibrillation | 2014 |
A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current.
Topics: Action Potentials; Animals; Female; Guinea Pigs; Heart Ventricles; Male; Models, Neurological; Myocytes, Cardiac; Protein Binding; Pyridines; Sodium Channel Blockers; Sodium Channels; Triazoles; Ventricular Function | 2015 |
Atria are More Sensitive Than Ventricles to GS-458967-Induced Inhibition of Late Sodium Current.
Topics: Animals; Dogs; Electrophysiological Phenomena; Heart Atria; Heart Ventricles; Pyridines; Sodium Channel Blockers; Sodium Channels; Triazoles | 2015 |
Selective late INa inhibition by GS-458967 exerts parallel suppression of catecholamine-induced hemodynamically significant ventricular tachycardia and T-wave alternans in an intact porcine model.
Topics: Animals; Blood Pressure; Disease Models, Animal; Electrocardiography; Epinephrine; Heart Rate; Pyridines; Swine; Tachycardia, Ventricular; Triazoles | 2015 |
Molecular Basis of Hypokalemia-Induced Ventricular Fibrillation.
Topics: Action Potentials; Animals; Benzylamines; Computer Simulation; Hypokalemia; Male; Phenethylamines; Pyridines; Rabbits; Rats; Rats, Inbred F344; Sodium-Potassium-Exchanging ATPase; Sulfonamides; Triazoles; Ventricular Fibrillation | 2015 |
The Selective Cardiac Late Sodium Current Inhibitor GS-458967 Suppresses Autonomically Triggered Atrial Fibrillation in an Intact Porcine Model.
Topics: Acetylcholine; Animals; Anti-Arrhythmia Agents; Arterial Pressure; Atrial Fibrillation; Autonomic Nervous System Diseases; Electric Stimulation; Electrocardiography; Epinephrine; Heart Rate; Male; Pyridines; Sodium Channel Blockers; Sus scrofa; Swine; Triazoles | 2015 |
Inhibition of late Na+ current, a novel target to improve diastolic function and electrical abnormalities in Dahl salt-sensitive rats.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Dose-Response Relationship, Drug; Heart Conduction System; Heart Failure; Heart Rate; Hypertrophy, Left Ventricular; Male; Myocardial Contraction; Myocytes, Cardiac; Oxidative Stress; Pyridines; Rats, Inbred Dahl; Sodium Channel Blockers; Sodium Channels; Sodium Chloride, Dietary; Time Factors; Triazoles; Ventricular Dysfunction, Left; Ventricular Function, Left | 2016 |
Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late INai) of the cardiac NaV 1.5 channel with improved efficacy and potency relative to ranolazine.
Topics: Animals; Caco-2 Cells; Dose-Response Relationship, Drug; Drug Discovery; Ether-A-Go-Go Potassium Channels; Heart; Humans; Macaca fascicularis; Microsomes, Liver; Molecular Structure; NAV1.5 Voltage-Gated Sodium Channel; Pyridines; Rabbits; Ranolazine; Rats; Sodium Channel Blockers; Structure-Activity Relationship; Triazoles | 2016 |
Use-Dependent Block of Human Cardiac Sodium Channels by GS967.
Topics: Anesthetics; Humans; Ion Channel Gating; Lidocaine; Myocardium; Pyridines; Ranolazine; Sodium Channel Blockers; Sodium Channels; Triazoles | 2016 |
A computational model predicts adjunctive pharmacotherapy for cardiac safety via selective inhibition of the late cardiac Na current.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cell Survival; Computer Simulation; Drug-Related Side Effects and Adverse Reactions; Electrocardiography; Heart; Humans; Models, Biological; Myocardium; Myocytes, Cardiac; Patch-Clamp Techniques; Pyridines; Rabbits; Sodium Channels; Triazoles | 2016 |
Effects of Late Sodium Current Blockade on Ventricular Refibrillation in a Rabbit Model.
Topics: Animals; Calcium; Calcium Channels; Disease Models, Animal; Electric Countershock; Heart Arrest; Logistic Models; Pyridines; Rabbits; Random Allocation; Ranolazine; Reference Values; Sodium Channel Blockers; Sodium Channels; Statistics, Nonparametric; Triazoles; Ventricular Fibrillation | 2017 |
Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 in murine Scn5a-1798insD+/- and human SCN5A-1795insD+/- iPSC-derived cardiomyocytes.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cell Line; Epicardial Mapping; Female; Genetic Predisposition to Disease; Heart Rate; Induced Pluripotent Stem Cells; Isolated Heart Preparation; Kinetics; Long QT Syndrome; Male; Mice, Transgenic; Mutation; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Phenotype; Pyridines; Triazoles; Voltage-Gated Sodium Channel Blockers | 2017 |
Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome.
Topics: Action Potentials; Animals; Epilepsies, Myoclonic; Ion Channel Gating; Mice, Inbred C57BL; Mice, Knockout; NAV1.1 Voltage-Gated Sodium Channel; NAV1.6 Voltage-Gated Sodium Channel; Neurons; Pyramidal Cells; Pyridines; Seizures; Survival Analysis; Triazoles | 2017 |
Selective inhibition of physiological late Na
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Disease Models, Animal; Female; Heart Rate; Heart Ventricles; In Vitro Techniques; Isolated Heart Preparation; Kinetics; Myocytes, Cardiac; Piperidines; Pyridines; Rabbits; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Triazoles | 2018 |
I
Topics: 4-Aminopyridine; Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Electrophysiological Phenomena; Heart Atria; Kinetics; Myocytes, Cardiac; Nifedipine; Potassium Channel Blockers; Pyridines; Rabbits; Single-Cell Analysis; Sodium Channel Blockers; Sodium Channels; Triazoles | 2018 |
Late sodium current inhibitors to treat exercise-induced obstruction in hypertrophic cardiomyopathy: an in vitro study in human myocardium.
Topics: Adrenergic beta-Antagonists; Cardiomyopathy, Hypertrophic; Cohort Studies; Dose-Response Relationship, Drug; Exercise; Female; Humans; Male; Middle Aged; Myocardium; Pyridines; Ranolazine; Sodium; Sodium Channel Blockers; Triazoles | 2018 |
Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Dose-Response Relationship, Drug; Myocytes, Cardiac; Phenethylamines; Pyridines; Sulfonamides; Torsades de Pointes; Triazoles | 2018 |
The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy.
Topics: Action Potentials; Animals; Anticonvulsants; Brain Diseases; Disease Models, Animal; Drug Administration Schedule; Electroshock; Epilepsy; Female; Hippocampus; Humans; Male; Mice; Mice, Transgenic; Mutation; NAV1.6 Voltage-Gated Sodium Channel; Neurons; Off-Label Use; Phenytoin; Pyridines; Triazoles | 2018 |
Effects of the Inhibition of Late Sodium Current by GS967 on Stretch-Induced Changes in Cardiac Electrophysiology.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Disease Models, Animal; Dose-Response Relationship, Drug; Isolated Heart Preparation; Male; Mechanoreceptors; Mechanotransduction, Cellular; Myocytes, Cardiac; Pyridines; Rabbits; Refractory Period, Electrophysiological; Sodium Channel Blockers; Sodium Channels; Time Factors; Triazoles; Ventricular Fibrillation | 2018 |
Increase of late sodium current contributes to enhanced susceptibility to atrial fibrillation in diabetic mice.
Topics: Action Potentials; Animals; Atrial Fibrillation; Diabetes Mellitus, Experimental; Electrophysiological Phenomena; Male; Mice; Mice, Inbred C57BL; Pyridines; Sodium; Sodium Channel Blockers; Triazoles | 2019 |
A single-center SCN8A-related epilepsy cohort: clinical, genetic, and physiologic characterization.
Topics: Cell Culture Techniques; Child; Cohort Studies; Epilepsy; Female; HEK293 Cells; Humans; Infant; Infant, Newborn; Male; Mutation; NAV1.6 Voltage-Gated Sodium Channel; Oxcarbazepine; Pyridines; Seizures; Sodium Channels; Triazoles | 2019 |
Involvement of the persistent Na
Topics: Action Potentials; Animals; Atrial Fibrillation; Cells, Cultured; Diastole; Guinea Pigs; Lidocaine; Male; Membrane Potentials; Myocytes, Cardiac; Pulmonary Veins; Pyridines; Sodium; Tetrodotoxin; Triazoles | 2019 |
Late sodium current blocker GS967 inhibits persistent currents induced by familial hemiplegic migraine type 3 mutations of the SCN1A gene.
Topics: Action Potentials; Epilepsy; HEK293 Cells; Humans; Migraine Disorders; Migraine with Aura; Mutation; NAV1.1 Voltage-Gated Sodium Channel; Neurons; Pyridines; Sodium; Triazoles | 2019 |
Differential Inhibition of Human Nav1.2 Resurgent and Persistent Sodium Currents by Cannabidiol and GS967.
Topics: Action Potentials; Animals; Anticonvulsants; Cannabidiol; Epilepsy; HEK293 Cells; Humans; Ion Channel Gating; Mice; Mutation; NAV1.2 Voltage-Gated Sodium Channel; Neurons; Protein Isoforms; Pyridines; Triazoles | 2020 |
GS-967 and Eleclazine Block Sodium Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Topics: Action Potentials; Anti-Arrhythmia Agents; Cells, Cultured; Humans; Induced Pluripotent Stem Cells; Ion Channel Gating; Lidocaine; Myocytes, Cardiac; Oxazepines; Pyridines; Ranolazine; Sodium Channel Blockers; Sodium Channels; Triazoles | 2020 |
Arrhythmogenic and antiarrhythmic actions of late sustained sodium current in the adult human heart.
Topics: Adult; Atrial Fibrillation; Calcium; Cnidarian Venoms; ERG1 Potassium Channel; Heart Atria; Humans; Membrane Potentials; Models, Cardiovascular; Myocytes, Cardiac; Piperidines; Pyridines; Ranolazine; Sodium; Triazoles | 2021 |