Compounds > triazoles
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triazoles and Angiogenesis, Pathologic

triazoles has been researched along with Angiogenesis, Pathologic in 47 studies

Research

Studies (47)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (12.77)18.2507
2000's15 (31.91)29.6817
2010's25 (53.19)24.3611
2020's1 (2.13)2.80

Authors

AuthorsStudies
Lei, H; Tang, L; Wu, W; Xia, X; Xu, H; Yao, F1
Cohen, PR1
Barrera, JA; Brownlee, M; Duscher, D; Fischer, LH; Giacco, F; Gurtner, GC; Hu, MS; Januszyk, M; Khong, S; Kwon, SH; Longaker, MT; Maan, ZN; Walmsley, GG; Whittam, AJ; Wong, VW1
Romanchikova, N; Trapencieris, P; Turks, M; Zemītis, J1
Chaturvedi, P; Gilkes, DM; Hu, H; Liang, H; Luo, W; Semenza, GL; Takano, N; Xiang, L1
Bejot, R; Goggi, J; Moonshi, SS; Robins, EG1
Borger, P; Dessus-Babus, S; Gosens, R; Hostettler Haack, K; Keglowich, L; Lardinois, D; Oliver, B; Philippova, M; Resink, T; Roth, M; Tamm, M; Tjin, G1
Hirakawa, H; Mizunuma, H; Yokoyama, Y; Yoshida, H1
Fearnley, GW; Fishwick, CW; Gage, MC; Homer-Vanniasinkam, S; Kankanala, J; Kearney, MT; Latham, AM; Ponnambalam, S; Wheatcroft, SB1
Annamalai, P; Gavara, G; Hiriyan, J; Natesan, S; Sambasivam, G; Shivarudraiah, P; Sukumaran, SK1
Andreucci, E; Bianchini, F; Bottoncetti, A; Calorini, L; Fabbrizzi, P; Guarna, A; Menchi, G; Passeri, A; Pupi, A; Raspanti, S; Trabocchi, A1
Cheng, J; Hong, Q; Jia, X; Lei, L; Li, D; Li, J; Liu, G; Mo, M; Shao, Z; Shen, Z; Wang, Y1
Allison, S; Hoang, KG; Murray, M; Petrovic, N1
Ali Alharbi, S; Ananda, H; Baburajeev, CP; Bender, A; Chinnathambi, A; Dhananjaya Mohan, C; Fuchs, JE; Girish, KS; Jagadish, S; Li, F; Rangappa, KS; Rangappa, S; Sethi, G; Sivaraman Siveen, K; Zayed, ME; Zhang, J1
Ahirwar, DK; Ganju, RK; Li, DY; Nasser, MW; Oghumu, S; Powell, CA; Satoskar, AR; Wilkie, T; Zhao, H1
Baker, LH; Bid, HK; Guttridge, DC; Houghton, PJ; Lin, J; London, C; Mo, X; Phelps, DA; Xaio, L1
Alizadeh, AM; Amani Shalamzari, S; Isanejad, A; Khodayari, H; Khodayari, S; Khojastehnjad, N; Khori, V1
Baban, D; Bridges, E; da Motta, LL; De Bastiani, MA; Ebner, D; Haider, S; Harris, AL; Klamt, F; Knapp, S; Ledaki, I; Li, JL; McIntyre, A; Morotti, M; Purshouse, K; Steers, G; Wigfield, S1
Athota, VR; Day, CJ; Elsworth, B; Freeman, R; Gasch, C; Mellick, AS; Mittal, V; Nikolic, I; Pouliot, N; Rasighaemi, P; Rogers, K; Sax, MJ; Swarbrick, A; Wei, M; Westcott, DE1
Andrade, LN; Chammas, R; de Oliveira, SI; Fernandes, PD; Jancar, S; Nonogaki, S; Onuchic, AC; Pinheiro, MC; Rohde, CB1
A'Hern, R; Banerjee, S; Detre, S; Dowsett, M; Evans, DB; Littlewood-Evans, AJ; Martin, LA1
Bianchini, F; Bottoncetti, A; Calorini, L; Cini, N; Guarna, A; Menchi, G; Pupi, A; Raspanti, S; Trabocchi, A1
Aihara, Y; Fukui, H; Ikenaka, Y; Kaji, K; Kawaratani, H; Kitade, M; Namisaki, T; Noguchi, R; Shirai, Y; Tsujimoto, T; Yanase, K; Yoshii, J; Yoshiji, H1
Fujii, Y; Goitsuka, R; Igarashi, Y; Nakazawa, K; Ohtake, H; Ono, N; Takayama, T; Ueda, Y1
Ashokan, B; Bharathan, A; Komalam, RJ; Rajasekharan, KN; Santhoshkumar, TR; Sengupta, S; Sreerekha, KV; Thamkachy, R; Thomas, SA1
Alessandro, R; Corrado, C; De Leo, G; Flugy, AM; Guggino, G; Karmali, R; Raimondo, S; Taverna, S1
Bruneteau, G; Clément, O; Cuénod, CA; Frija, G; Frouin, F; Kahn, E; Pradel, C; Siauve, N1
Doong, H; Kassis, J; Kohn, EC; Patton, AM1
Chiles, J; Kohn, EC; Moody, E; Moody, TW; Sieczkiewicz, GJ1
Desai, S; Kohn, EC; Libutti, SK; Lorang, D; Oliver, VK; Patton, AM1
Bruneteau, G; Clement, O; Cuenod, CA; de Bazelaire, C; Frija, G; Frouin, F; Pradel, C; Robert, PH; Siauve, N; Tessier, JL; Wedge, SR1
Armeanu, S; Fersis, N; Friedrich, M; Gagulic, E; Pantic, L; Relakis, K; Smyczek-Gargya, B; Wallwiener, D1
He, S; Hoffmann, S; Wiedemann, P1
Hollis, D; Mahoney, J; Ratain, MJ; Rini, B; Rosner, G; Small, E; Stadler, WM; Zaentz, SD1
Balvay, D; Bessoud, B; Bois, FY; Brochot, C; Cuénod, CA; Siauve, N1
Antoniotti, S; Bussolati, B; Fiorio Pla, A; Grange, C; Merlino, A; Munaron, L; Tomatis, C1
Murphy, PV; O'Boyle, KM; Zhao, Y; Zhou, Y1
Battaglia, E; Bussolino, F; Camussi, G; Emanuelli, G; Lupia, E; Montrucchio, G; Passerini, G1
Alessandro, R; Kohn, EC; Liotta, LA; Spoonster, J; Wersto, RP1
Aglietta, M; Arese, M; Barra, L; Benelli, R; Bussolino, F; Ghigo, D; Montrucchio, G; Primo, L; Rola-Pleszczynski, MR; Sanavio, F1
Kuwano, M; Ono, M1
de la Cruz, JP; García-Campos, J; Moreno, A; Ruiz-Ruiz, MI; Sánchez de la Cuesta, F1
Bu, W; Li, XM; Qin, LX; Tang, ZY; Xia, JL1
Bauer, KS; Cude, KJ; Dixon, SC; Figg, WD; Kruger, EA1
Biancone, L; Bussolati, B; Camussi, G; Cassoni, P; Montrucchio, G; Rola-Pleszczynski, M; Russo, S1
Bauer, KS; Bostick-Bruton, F; Figg, WD; Fuse, E; Goldspiel, B; Kohn, EC; Kulpa, V; Liotta, LA; Minasian, L; Noone, M; Pluda, J; Reed, E; Sarosy, GA; Tompkins, A1
Figg, WD; Krüger, EA1

Reviews

2 review(s) available for triazoles and Angiogenesis, Pathologic

ArticleYear
Calcium as a molecular target in angiogenesis.
    Current pharmaceutical design, 2003, Volume: 9, Issue:7

    Topics: Calcium; Calcium Channel Blockers; Calcium Signaling; Cell Membrane; Humans; Neoplasms; Neovascularization, Pathologic; Neovascularization, Physiologic; Triazoles

2003
[Development of anti tumor agents targeting angiogenesis].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:2

    Topics: Antineoplastic Agents; Clinical Trials as Topic; Cyclohexanes; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Hydroxamic Acids; Interferon-alpha; Interleukin-12; Neoplasms; Neovascularization, Pathologic; O-(Chloroacetylcarbamoyl)fumagillol; Phenylalanine; Platelet Factor 4; Polysaccharides, Bacterial; Sesquiterpenes; Thalidomide; Thiophenes; Triazines; Triazoles; Tumor Cells, Cultured

1997

Trials

2 trial(s) available for triazoles and Angiogenesis, Pathologic

ArticleYear
Successful implementation of the randomized discontinuation trial design: an application to the study of the putative antiangiogenic agent carboxyaminoimidazole in renal cell carcinoma--CALGB 69901.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Jun-01, Volume: 23, Issue:16

    Topics: Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antineoplastic Agents; Carcinoma, Renal Cell; Disease-Free Survival; Double-Blind Method; Female; Humans; Kidney Neoplasms; Male; Middle Aged; Neovascularization, Pathologic; Research Design; Survival Rate; Treatment Outcome; Triazoles

2005
A phase I trial of carboxyamido-triazole and paclitaxel for relapsed solid tumors: potential efficacy of the combination and demonstration of pharmacokinetic interaction.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:6

    Topics: Adult; Aged; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Inhibitory Concentration 50; Male; Mice; Mice, Nude; Middle Aged; Neoplasms; Neovascularization, Pathologic; Ovarian Neoplasms; Paclitaxel; Recurrence; Time Factors; Treatment Outcome; Triazoles; Tumor Cells, Cultured

2001

Other Studies

43 other study(ies) available for triazoles and Angiogenesis, Pathologic

ArticleYear
Normal vitreous promotes angiogenesis via activation of Axl.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, Volume: 35, Issue:1

    Topics: Animals; Axl Receptor Tyrosine Kinase; Benzocycloheptenes; CRISPR-Cas Systems; Diabetic Retinopathy; Enzyme Activation; HEK293 Cells; Humans; Mice; Neovascularization, Pathologic; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Retinal Vessels; Triazoles; Vitreoretinopathy, Proliferative; Vitreous Body

2021
Melasma treatment: A novel approach using a topical agent that contains an anti-estrogen and a vascular endothelial growth factor inhibitor.
    Medical hypotheses, 2017, Volume: 101

    Topics: Administration, Topical; Anastrozole; Androstadienes; Aromatase Inhibitors; Estrogens; Female; Genetic Predisposition to Disease; Humans; Hyperpigmentation; Letrozole; Male; Melanosis; Neovascularization, Pathologic; Nitriles; Pregnancy; Raloxifene Hydrochloride; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles; Ultraviolet Rays; Vascular Endothelial Growth Factor A

2017
Small molecule inhibition of dipeptidyl peptidase-4 enhances bone marrow progenitor cell function and angiogenesis in diabetic wounds.
    Translational research : the journal of laboratory and clinical medicine, 2019, Volume: 205

    Topics: Animals; Chemokine CXCL12; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Glipizide; Hematopoietic Stem Cells; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Triazoles; Wound Healing; Wounds and Injuries

2019
A novel matrix metalloproteinase-2 inhibitor triazolylmethyl aziridine reduces melanoma cell invasion, angiogenesis and targets ERK1/2 phosphorylation.
    Journal of enzyme inhibition and medicinal chemistry, 2014, Volume: 29, Issue:6

    Topics: Animals; Aziridines; Cell Line, Tumor; Cell Movement; Collagen; Diffusion Chambers, Culture; Drug Combinations; Gene Expression Regulation, Neoplastic; Human Umbilical Vein Endothelial Cells; Humans; Laminin; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Melanoma, Experimental; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neovascularization, Pathologic; Phosphorylation; Proteoglycans; Signal Transduction; Tetradecanoylphorbol Acetate; Triazoles; Vascular Endothelial Growth Factor A

2014
Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer.
    Journal of molecular medicine (Berlin, Germany), 2014, Volume: 92, Issue:2

    Topics: Animals; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Glucose Transporter Type 1; HSP90 Heat-Shock Proteins; Humans; Hypoxia-Inducible Factor 1; Immunoblotting; Immunohistochemistry; Mice; Mice, SCID; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplastic Stem Cells; Neovascularization, Pathologic; Neural Cell Adhesion Molecule L1; Reverse Transcriptase Polymerase Chain Reaction; Triazoles; Triple Negative Breast Neoplasms; Tumor Burden; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

2014
A practical synthesis of [(18) F]FtRGD: an angiogenesis biomarker for PET.
    Journal of labelled compounds & radiopharmaceuticals, 2013, Volume: 56, Issue:2

    Topics: Animals; Ligands; Mice; Neoplasms, Experimental; Neovascularization, Pathologic; Peptides, Cyclic; Positron-Emission Tomography; Radiopharmaceuticals; Tissue Distribution; Triazoles

2013
Bronchial smooth muscle cells of asthmatics promote angiogenesis through elevated secretion of CXC-chemokines (ENA-78, GRO-α, and IL-8).
    PloS one, 2013, Volume: 8, Issue:12

    Topics: Adult; Asthma; Bronchi; Chemokine CXCL1; Chemokine CXCL5; Chemokines, CXC; Female; Humans; Interleukin-8; Ligands; Male; Middle Aged; Myocytes, Smooth Muscle; Neovascularization, Pathologic; Phenylurea Compounds; Receptors, Interleukin-8B; Triazoles; Young Adult

2013
Inhibitory effects of aromatase inhibitor on estrogen receptor-alpha positive ovarian cancer in mice.
    Journal of ovarian research, 2014, Jan-10, Volume: 7

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Hormonal; Apoptosis; Aromatase; Aromatase Inhibitors; Ascites; Cell Line, Tumor; Estrogen Receptor alpha; Female; Forkhead Transcription Factors; Humans; Letrozole; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Nitriles; Ovarian Neoplasms; Ovariectomy; Peritoneal Neoplasms; Repressor Proteins; Signal Transduction; Time Factors; Triazoles; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

2014
In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis.
    PloS one, 2014, Volume: 9, Issue:11

    Topics: Angiogenesis Inhibitors; Aniline Compounds; Animals; Breast Neoplasms; CDC2 Protein Kinase; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Drug Design; Endothelial Cells; Female; Humans; Male; MCF-7 Cells; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neovascularization, Pathologic; Neovascularization, Physiologic; Protein Kinase Inhibitors; Signal Transduction; Triazoles; Vascular Endothelial Growth Factor Receptor-2; Wound Healing

2014
Discovery of PAT-1102, a novel, potent and orally active histone deacetylase inhibitor with antitumor activity in cancer mouse models.
    Anticancer research, 2015, Volume: 35, Issue:1

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Apoptosis; HCT116 Cells; HeLa Cells; Histone Deacetylase Inhibitors; Human Umbilical Vein Endothelial Cells; Humans; Hydroxamic Acids; Inhibitory Concentration 50; Male; Mice, Inbred BALB C; Mice, Nude; Mice, SCID; Neoplasms, Experimental; Neovascularization, Pathologic; Triazoles; Vorinostat; Xenograft Model Antitumor Assays

2015
Radiosynthesis and micro-SPECT analysis of triazole-based RGD integrin ligands as non-peptide molecular imaging probes for angiogenesis.
    Bioorganic & medicinal chemistry, 2015, Mar-01, Volume: 23, Issue:5

    Topics: Animals; Heterografts; Humans; Integrins; Ligands; Melanoma; Mice; Models, Molecular; Molecular Probes; Neovascularization, Pathologic; Oligopeptides; Tomography, Emission-Computed, Single-Photon; Triazoles

2015
Basal and therapy-driven hypoxia-inducible factor-1α confers resistance to endocrine therapy in estrogen receptor-positive breast cancer.
    Oncotarget, 2015, Apr-20, Volume: 6, Issue:11

    Topics: Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Diphosphonates; Drug Resistance, Neoplasm; Estradiol; Estrogens; Female; Fulvestrant; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Letrozole; MAP Kinase Signaling System; Mice; Mice, Nude; Neoadjuvant Therapy; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Neovascularization, Pathologic; Nitriles; Postmenopause; Receptors, Estrogen; RNA Interference; RNA, Small Interfering; Transcription, Genetic; Treatment Outcome; Triazoles; Xenograft Model Antitumor Assays; Zoledronic Acid

2015
Prostanoids regulate angiogenesis acting primarily on IP and EP4 receptors.
    Microvascular research, 2015, Volume: 101

    Topics: Benzyl Compounds; Cell Movement; Dinoprostone; Endothelial Cells; Epoprostenol; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Neovascularization, Pathologic; Neovascularization, Physiologic; Prostaglandins I; Real-Time Polymerase Chain Reaction; Receptors, Epoprostenol; Receptors, G-Protein-Coupled; Receptors, Prostaglandin E, EP4 Subtype; Thiophenes; Triazoles; Xanthones

2015
Development of Novel Triazolo-Thiadiazoles from Heterogeneous "Green" Catalysis as Protein Tyrosine Phosphatase 1B Inhibitors.
    Scientific reports, 2015, Sep-21, Volume: 5

    Topics: Animals; Antineoplastic Agents; Benzofurans; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Cell Movement; Chromones; Cyclin D1; Disease Models, Animal; Dose-Response Relationship, Drug; Female; G1 Phase Cell Cycle Checkpoints; Hep G2 Cells; Human Umbilical Vein Endothelial Cells; Humans; Inhibitor of Apoptosis Proteins; Liver Neoplasms; Mice; Models, Molecular; Neoplasm Invasiveness; Neovascularization, Pathologic; Poly(ADP-ribose) Polymerases; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; STAT3 Transcription Factor; Structure-Activity Relationship; Survivin; Thiadiazoles; Triazoles

2015
Endothelial Robo4 suppresses breast cancer growth and metastasis through regulation of tumor angiogenesis.
    Molecular oncology, 2016, Volume: 10, Issue:2

    Topics: ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Animals; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Down-Regulation; Endothelial Cells; Female; Gene Knockout Techniques; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neovascularization, Pathologic; Nerve Tissue Proteins; Receptors, Cell Surface; Receptors, Immunologic; Signal Transduction; Triazoles; Vascular Endothelial Growth Factor A; Zonula Occludens-1 Protein

2016
The Bromodomain BET Inhibitor JQ1 Suppresses Tumor Angiogenesis in Models of Childhood Sarcoma.
    Molecular cancer therapeutics, 2016, Volume: 15, Issue:5

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Azepines; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Child; Disease Models, Animal; Drug Resistance, Neoplasm; Human Umbilical Vein Endothelial Cells; Humans; Mice; Neovascularization, Pathologic; Proto-Oncogene Proteins c-myc; Sarcoma; Transcription Factor AP-1; Triazoles; Xenograft Model Antitumor Assays

2016
MicroRNA-206, let-7a and microRNA-21 pathways involved in the anti-angiogenesis effects of the interval exercise training and hormone therapy in breast cancer.
    Life sciences, 2016, Apr-15, Volume: 151

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Combined Modality Therapy; Exercise Therapy; Female; Letrozole; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; MicroRNAs; Muscle, Skeletal; Neovascularization, Pathologic; Nitriles; Signal Transduction; Tamoxifen; Triazoles

2016
The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer.
    Oncogene, 2017, 01-05, Volume: 36, Issue:1

    Topics: Animals; Azepines; Carbonic Anhydrase IX; Cell Line, Tumor; Cluster Analysis; Disease Models, Animal; Female; Gene Expression Profiling; High-Throughput Nucleotide Sequencing; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Neovascularization, Pathologic; Promoter Regions, Genetic; Protein Binding; Spheroids, Cellular; Transcriptome; Triazoles; Triple Negative Breast Neoplasms; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

2017
Cancer cell CCL5 mediates bone marrow independent angiogenesis in breast cancer.
    Oncotarget, 2016, Dec-20, Volume: 7, Issue:51

    Topics: Angiogenesis Inhibitors; Animals; Breast Neoplasms; CCR5 Receptor Antagonists; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemokine CCL5; Culture Media, Conditioned; Cyclohexanes; Endothelial Cells; Female; Humans; Maraviroc; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Neoplasm Grading; Neoplasm Invasiveness; Neovascularization, Pathologic; Paracrine Communication; Proto-Oncogene Proteins c-akt; Receptors, CCR5; Signal Transduction; Time Factors; TOR Serine-Threonine Kinases; Triazoles; Tumor Burden; Tumor Microenvironment

2016
Platelet-activating factor receptor (PAF-R)-dependent pathways control tumour growth and tumour response to chemotherapy.
    BMC cancer, 2010, May-13, Volume: 10

    Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azepines; Carcinoma, Ehrlich Tumor; Caspase 3; Cell Proliferation; Cyclooxygenase 2; Dacarbazine; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Galectin 3; Immunohistochemistry; Macrophages; Male; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neovascularization, Pathologic; Nitric Oxide; Phenotype; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Signal Transduction; Time Factors; Triazoles; Tumor Burden; Vascular Endothelial Growth Factor A

2010
Biological evidence for dual antiangiogenic-antiaromatase activity of the VEGFR inhibitor PTK787/ZK222584 in vivo.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2010, Aug-15, Volume: 16, Issue:16

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Aromatase; Aromatase Inhibitors; Cell Line, Tumor; Cell Proliferation; Female; Humans; Immunohistochemistry; Letrozole; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neovascularization, Pathologic; Nitriles; Phthalazines; Pyridines; Receptors, Estrogen; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Triazoles; Xenograft Model Antitumor Assays

2010
Click-chemistry-derived triazole ligands of arginine-glycine-aspartate (RGD) integrins with a broad capacity to inhibit adhesion of melanoma cells and both in vitro and in vivo angiogenesis.
    Journal of medicinal chemistry, 2010, Oct-14, Volume: 53, Issue:19

    Topics: Alkynes; Angiogenesis Inhibitors; Animals; Azides; Cell Adhesion; Cell Line, Tumor; Drug Screening Assays, Antitumor; Endothelial Cells; Extracellular Matrix Proteins; Humans; Integrin alphaVbeta3; Ligands; Melanoma; Mice; Mice, Inbred C57BL; Models, Molecular; Molecular Mimicry; Neovascularization, Pathologic; Oligopeptides; Phenylpropionates; Protein Binding; Radioligand Assay; Receptors, Vitronectin; Stereoisomerism; Structure-Activity Relationship; Triazoles

2010
Combination treatment of angiotensin II type I receptor blocker and new oral iron chelator attenuates progression of nonalcoholic steatohepatitis in rats.
    American journal of physiology. Gastrointestinal and liver physiology, 2011, Volume: 300, Issue:6

    Topics: Administration, Oral; Angiogenesis Inhibitors; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Benzoates; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Cultured; Choline Deficiency; Deferasirox; Disease Progression; Drug Therapy, Combination; Fatty Liver; Hepatic Stellate Cells; Iron Chelating Agents; Liver Cirrhosis, Experimental; Liver Neoplasms, Experimental; Losartan; Male; Neovascularization, Pathologic; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Rats; Rats, Inbred F344; Time Factors; Transforming Growth Factor beta1; Triazoles

2011
Blocking S1P interaction with S1P₁ receptor by a novel competitive S1P₁-selective antagonist inhibits angiogenesis.
    Biochemical and biophysical research communications, 2012, Mar-23, Volume: 419, Issue:4

    Topics: Cell Line, Tumor; Human Umbilical Vein Endothelial Cells; Humans; Lysophospholipids; Neoplasms; Neovascularization, Pathologic; Neovascularization, Physiologic; Receptors, Lysosphingolipid; Sphingosine; Sphingosine-1-Phosphate Receptors; Sulfones; Triazoles; Vascular Endothelial Growth Factor A

2012
Diaminothiazoles inhibit angiogenesis efficiently by suppressing Akt phosphorylation.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 341, Issue:3

    Topics: Angiogenesis Inhibitors; Animals; Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; Chick Embryo; Chorioallantoic Membrane; Cyclin-Dependent Kinases; Human Umbilical Vein Endothelial Cells; Humans; Microtubules; Neovascularization, Pathologic; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Thiazoles; Triazoles; Vascular Endothelial Growth Factor A

2012
Carboxyamidotriazole-orotate inhibits the growth of imatinib-resistant chronic myeloid leukaemia cells and modulates exosomes-stimulated angiogenesis.
    PloS one, 2012, Volume: 7, Issue:8

    Topics: Animals; Antineoplastic Agents; Benzamides; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; Exosomes; Extracellular Signal-Regulated MAP Kinases; Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; Human Umbilical Vein Endothelial Cells; Humans; Imatinib Mesylate; Interleukin-8; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Mice; Neovascularization, Pathologic; Orotic Acid; Phosphorylation; Phosphotyrosine; Piperazines; Proto-Oncogene Proteins c-akt; Pyrimidines; RNA, Messenger; Triazoles; Xenograft Model Antitumor Assays

2012
Assessing perfusion and capillary permeability changes induced by a VEGF inhibitor in human tumor xenografts using macromolecular MR imaging contrast media.
    Academic radiology, 2002, Volume: 9 Suppl 2

    Topics: Animals; Capillary Permeability; Contrast Media; Endothelial Growth Factors; Gadolinium; Heterocyclic Compounds; Intercellular Signaling Peptides and Proteins; Lymphokines; Macromolecular Substances; Magnetic Resonance Imaging; Male; Mice; Mice, Nude; Microcirculation; Neoplasm Transplantation; Neovascularization, Pathologic; Organometallic Compounds; Perfusion; Prostatic Neoplasms; Quinazolines; Transplantation, Heterologous; Triazoles; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2002
CAI inhibits the growth of small cell lung cancer cells.
    Lung cancer (Amsterdam, Netherlands), 2003, Volume: 39, Issue:3

    Topics: Animals; Antineoplastic Agents; Carcinoma, Small Cell; Cell Division; Dose-Response Relationship, Drug; Humans; Lung Neoplasms; Mice; Mice, Nude; Neoplasms, Experimental; Neovascularization, Pathologic; Transplantation, Heterologous; Triazoles; Tumor Cells, Cultured

2003
Regulation of the pro-angiogenic microenvironment by carboxyamido-triazole.
    Journal of cellular physiology, 2003, Volume: 197, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Movement; Cell Transplantation; Culture Media; Endothelial Growth Factors; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hydrogen-Ion Concentration; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Interleukin-8; Lymphokines; Melanoma; Mice; Neovascularization, Pathologic; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors; Transplantation, Heterologous; Triazoles; Tumor Cells, Cultured; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2003
Reduced capillary perfusion and permeability in human tumour xenografts treated with the VEGF signalling inhibitor ZD4190: an in vivo assessment using dynamic MR imaging and macromolecular contrast media.
    Magnetic resonance imaging, 2003, Volume: 21, Issue:8

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Capillary Permeability; Cell Line, Tumor; Contrast Media; Magnetic Resonance Angiography; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Neovascularization, Pathologic; Quinazolines; Triazoles; Vascular Endothelial Growth Factor A

2003
Changes in vascular endothelial growth factor (VEGF) after chemoendocrine therapy in breast cancer.
    European journal of gynaecological oncology, 2004, Volume: 25, Issue:1

    Topics: Androstadienes; Angiopoietin-1; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; DNA Primers; Docetaxel; Dose-Response Relationship, Drug; Doxorubicin; Female; Gene Expression Regulation, Neoplastic; Humans; Letrozole; Neovascularization, Pathologic; Nitriles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Tamoxifen; Taxoids; Triazoles; Vascular Endothelial Growth Factor A

2004
[Carboxyamido-triazole inhibits substeps of choroidal neovascularization on retinal pigment epithelial cells and choroidal endothelial cells in vitro].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2004, Volume: 101, Issue:10

    Topics: Antineoplastic Agents; Calcium Channel Blockers; Cell Division; Cell Line; Cell Movement; Choroid; Endothelium, Vascular; Humans; In Vitro Techniques; Macular Degeneration; Neovascularization, Pathologic; Pigment Epithelium of Eye; Signal Transduction; Triazoles

2004
Evaluation of antiangiogenic treatment effects on tumors' microcirculation by Bayesian physiological pharmacokinetic modeling and magnetic resonance imaging.
    Magnetic resonance imaging, 2006, Volume: 24, Issue:8

    Topics: Animals; Bayes Theorem; Contrast Media; Heterocyclic Compounds; Magnetic Resonance Imaging; Male; Mice; Mice, Nude; Microcirculation; Neoplasm Transplantation; Neoplasms; Neovascularization, Pathologic; Organometallic Compounds; Quinazolines; Triazoles; Xenograft Model Antitumor Assays

2006
Arachidonic acid-induced Ca2+ entry is involved in early steps of tumor angiogenesis.
    Molecular cancer research : MCR, 2008, Volume: 6, Issue:4

    Topics: Arachidonic Acid; Breast Neoplasms; Calcium; Calcium Signaling; Cell Proliferation; Cell Separation; Humans; Neovascularization, Pathologic; Triazoles; Tumor Cells, Cultured

2008
Hybrids of 1-deoxynojirimycin and aryl-1,2,3-triazoles and biological studies related to angiogenesis.
    Bioorganic & medicinal chemistry, 2008, Jun-15, Volume: 16, Issue:12

    Topics: 1-Deoxynojirimycin; Aminopeptidases; Angiogenesis Inhibitors; Animals; Aorta; Apoptosis; Cattle; Cell Cycle; Cell Line; Cell Movement; Cell Proliferation; Cyclin D1; Endothelial Cells; Enzyme Inhibitors; Glycoside Hydrolase Inhibitors; Metalloendopeptidases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neovascularization, Pathologic; Neovascularization, Physiologic; Phosphorylation; Stress Fibers; Triazoles

2008
Tumor necrosis factor alpha-induced angiogenesis depends on in situ platelet-activating factor biosynthesis.
    The Journal of experimental medicine, 1994, Jul-01, Volume: 180, Issue:1

    Topics: Animals; Azepines; Collagen; Drug Combinations; Female; Laminin; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Platelet Activating Factor; Proteoglycans; Triazoles; Tumor Necrosis Factor-alpha

1994
Angiogenesis: role of calcium-mediated signal transduction.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Feb-28, Volume: 92, Issue:5

    Topics: Aminoimidazole Carboxamide; Calcium; Calcium Channel Blockers; Cell Adhesion; Cell Division; Cell Movement; Cells, Cultured; Collagen; Drug Combinations; Endothelium, Vascular; Extracellular Matrix Proteins; Fibroblast Growth Factor 2; Gelatinases; Humans; In Vitro Techniques; Laminin; Matrix Metalloproteinase 2; Metalloendopeptidases; Neovascularization, Pathologic; Phosphotyrosine; Proteoglycans; Signal Transduction; Triazoles; Tyrosine

1995
Platelet activating factor produced in vitro by Kaposi's sarcoma cells induces and sustains in vivo angiogenesis.
    The Journal of clinical investigation, 1995, Volume: 96, Issue:2

    Topics: Aged; Animals; Azepines; Base Sequence; Cell Line; Chemotaxis; Choriocarcinoma; Collagen; Culture Media, Conditioned; Cytokines; Dogs; Drug Combinations; Endothelium, Vascular; Female; Growth Substances; Humans; Interleukin-1; Laminin; Lymphoma, Large B-Cell, Diffuse; Macrophages; Male; Mice; Mice, Inbred DBA; Molecular Sequence Data; Neoplasm Proteins; Neovascularization, Pathologic; Platelet Activating Factor; Platelet Membrane Glycoproteins; Proteoglycans; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sarcoma, Kaposi; Skin Neoplasms; Thrombin; Triazoles; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Umbilical Veins; Uterine Neoplasms

1995
Effect of WEB 2086-BS, an antagonist of platelet-activating factor receptors, on retinal vascularity in diabetic rats.
    European journal of pharmacology, 1998, Oct-30, Volume: 360, Issue:1

    Topics: Analysis of Variance; Animals; Azepines; Blood Glucose; Blood Platelets; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Dose-Response Relationship, Drug; Epoprostenol; Lipid Peroxidation; Male; Neovascularization, Pathologic; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Retina; Thromboxane B2; Triazoles

1998
Effect of antiangiogenic agents on experimental animal models of hepatocellular carcinoma.
    Annals of the Academy of Medicine, Singapore, 1999, Volume: 28, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Division; Cyclohexanes; Liver Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Metastasis; Neovascularization, Pathologic; O-(Chloroacetylcarbamoyl)fumagillol; Phenylalanine; Sesquiterpenes; Suramin; Thiophenes; Triazoles

1999
Carboxyamido-triazole inhibits angiogenesis by blocking the calcium-mediated nitric-oxide synthase-vascular endothelial growth factor pathway.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 292, Issue:1

    Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Growth Factors; Endothelium, Vascular; Humans; In Vitro Techniques; Lymphokines; Male; Microcirculation; Neovascularization, Pathologic; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Triazoles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2000
PAF produced by human breast cancer cells promotes migration and proliferation of tumor cells and neo-angiogenesis.
    The American journal of pathology, 2000, Volume: 157, Issue:5

    Topics: Animals; Azepines; Breast Neoplasms; Cell Division; Cell Movement; Female; Humans; Mice; Mice, SCID; Neoplasm Transplantation; Neovascularization, Pathologic; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles; Tumor Cells, Cultured

2000
Protein binding alters the activity of suramin, carboxyamidotriazole, and UCN-01 in an ex vivo rat aortic ring angiogenesis assay.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:7

    Topics: Alkaloids; Angiogenesis Inhibitors; Animals; Aorta, Thoracic; Biological Assay; Blood Proteins; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Male; Neovascularization, Pathologic; Protein Binding; Rats; Rats, Sprague-Dawley; Staurosporine; Suramin; Triazoles

2001