triazoles has been researched along with Alloxan Diabetes in 74 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (4.05) | 18.7374 |
| 1990's | 4 (5.41) | 18.2507 |
| 2000's | 7 (9.46) | 29.6817 |
| 2010's | 54 (72.97) | 24.3611 |
| 2020's | 6 (8.11) | 2.80 |
| Authors | Studies |
|---|---|
| Carr, CA; Castro-Guarda, M; Dennis, KMJH; Heather, LC; Massourides, E; Montes Aparicio, CN; Purnama, U; Sousa Fialho, MDL; Tyler, DJ | 1 |
| Gupta, P; Khanam, S; Kumar Tewari, A; Mahapatra, A; Nidhar, M; Patil, S; Singh, RK; Sonker, P; Yadav, BK | 1 |
| Chung, CH; Ha, KB; Jeong, AR; Kim, DK; Kim, HM; Kukongviriyapan, U; Lee, ES; Lee, EY; Sangartit, W; Shim, S | 1 |
| Arora, S; Bedi, PMS; Chadha, R; Goswami, D; Kaur, K; Kaur, U; Mohana, P; Prajapati, J; Sharma, A; Singh, A; Singh, K | 1 |
| Chen, J; Efanov, AM; Fang, X; Jiang, Y; Jun Zhang, X; Li, L; Lin, HV; Liu, J; Liu, LZ; Long Hu, Z; Ma, T; Thomas, MK; Wang, F; Wang, J; Xiao, F; Xu, J; Zeng, M; Zhang, L; Zhen Zhang, H; Zhou, J; Zou, H; Zou, Z | 1 |
| Fukui, K; Hasegawa, S; Nangaku, M; Saito, T; Susaki, EA; Tanaka, T; Ueda, HR; Wakashima, T | 1 |
| Beladiya, JV; Chaudagar, KK; Mehta, AA | 1 |
| Deng, X; Han, L; Li, Q; Zhang, H; Zhou, J | 1 |
| Liang, E; Liu, X; Ma, M; Wang, L; Xu, J; Yang, R; Zhang, M; Zhao, Y | 1 |
| Cremonini, E; Oteiza, PI | 1 |
| Chen, J; Cheng, Y; Li, J; Shen, X; Shi, X; Xu, X; Yan, W; Zhou, J; Zhou, T | 1 |
| Chen, WJ; Guo, M; Wang, HX | 1 |
| Kakimoto, S; Kiso, T; Sekizawa, T; Tsukamoto, M; Uchino, H | 1 |
| Barrera, JA; Brownlee, M; Duscher, D; Fischer, LH; Giacco, F; Gurtner, GC; Hu, MS; Januszyk, M; Khong, S; Kwon, SH; Longaker, MT; Maan, ZN; Walmsley, GG; Whittam, AJ; Wong, VW | 1 |
| Huang, Q; Jiang, Y; Jin, X; Li, P; Lu, Y; Pan, Z; Shi, L; Su, W; Sun, Y; Wang, Z; Xue, G; Yang, B; Yuan, Y; Zhan, L; Zhang, Y; Zhao, Y; Zhu, H; Zhuang, Y | 1 |
| Ben Salem, A; Hamden, K; Hamzaoui, S; Kossentini, M; Mourer, M; Regnouf-De-Vains, JB | 1 |
| Badole, SL; Bagul, PP; Coutinho, EC; Ghule, AE; Jangam, GB; Joshi, AC; Khedkar, VM; Khose, RD; Mahamuni, SP; Raut, CG | 1 |
| Gao, H; Hu, J; Sun, R; Wang, F; Wang, L; Wang, Y; Wang, Z; Yan, S; Yu, X; Zhao, W | 1 |
| Epstein, S; Gallagher, EJ; Kornhauser, C; LeRoith, D; Sun, H; Tobin-Hess, A; Yakar, S | 1 |
| Badole, SL; Bagul, PP; Chaudhari, SM; Joshi, AC; Khose, RD; Mahamuni, SP; Raut, CG; Zanwar, AA | 1 |
| Sakr, HF | 1 |
| Cunningham, C; Dey, M; Forest, T; Frederick, C; Holder, D; Prahalada, S; Smith, A; Yao, X | 1 |
| Napoli, N | 1 |
| Ambrósio, AF; Fernandes, R; Gonçalves, A; Leal, E; Marques, C; Reis, F; Ribeiro, CF | 1 |
| Gudascheva, TA; Ivanova, EA; Kapitsa, IG; Ostrovskaya, RU; Ozerova, IV; Seredenin, SB; Voronina, TA | 1 |
| Fernandes, R; Fontes-Ribeiro, C; Gonçalves, A; Marques, C; Mega, C; Reis, F; Rodrigues-Santos, P; Teixeira, F; Teixeira-Lemos, E | 1 |
| Baerts, L; Behets, GJ; D'Haese, PC; De Meester, I; Glorie, L; Verhulst, A | 1 |
| Gudasheva, TA; Ivanova, EA; Kapitsa, IG; Michunskaya, AM; Ostrovskaya, RU; Ozerova, IV; Seredenin, SB; Taraban, KV; Voronina, TA; Zolotov, NN | 1 |
| Iwamura, T; Kainoh, M; Kawai, K; Kumagai, H; Nakaki, J; Nitta, A; Okazaki, S; Sakami, S; Sato, M; Sekiya, Y; Takahashi, T; Yagi, M | 1 |
| Baerts, L; De Keulenaer, GW; De Meester, I; Demolder, M; Hamdani, N; Hervent, AS; Linke, WA; Matheeussen, V; Paulus, WJ; Vandekerckhove, L | 1 |
| Benham, C; Dugic, E; Lione, L; Mackenzie, LS; Rehman, AU | 1 |
| Chopra, BS; Choudhary, V; Garg, R; Garg, V; Khatri, N; Peddada, N; Sagar, A | 1 |
| Ain-Shoka, AA; Attia, AS; El-Sahar, AE; Safar, MM; Zaki, HF | 1 |
| Al-Abdullah, ES; Al-Alshaikh, MA; Al-Tuwaijri, HM; El-Emam, AA; Habib, EE; Hassan, HM | 1 |
| Kharatmal, SB; Sharma, SS; Singh, JN | 1 |
| Abdullah, T; Baggio, LL; Bang, KW; Campbell, JE; Drucker, DJ; Mulvihill, EE; Ussher, JR; Varin, EM | 1 |
| Anderson, DG; Aresta-Dasilva, S; Bader, AR; Bochenek, MA; Chen, M; Doloff, JC; Gandham, S; Greiner, DL; Gürtler, M; Hollister-Lock, J; Jhunjhunwala, S; Langan, E; Langer, R; Li, J; McGarrigle, JJ; Melton, DA; Millman, JR; Oberholzer, J; Olejnik, K; Pagliuca, FW; Tam, HH; Vegas, AJ; Veiseh, O; Weir, GC | 1 |
| Arora, D; Duan, H; Li, Y; Lim, HY; Setiadi, H; Wang, W; Xu, D | 1 |
| Bender, K; Bugianesi, R; Costa, M; Dingley, K; Edmondson, S; Ehrhardt, A; Hagmann, WK; Kurukulasuriya, R; Li, X; Lombardo, M; Mitelman, S; Nargund, R; Parker, D; Priest, B; Ratliff, K; Sherer, EC; Sinz, C; Tong, S; Ujjainwalla, F; Wilson, JE | 1 |
| Ishii, Y; Ito, H; Kon, K; Sakurai, T; Sasahara, M; Sasaoka, T; Takahara, S; Toyooka, N; Tsuneki, H; Wada, T; Yamazaki, M; Yanagisawa, M | 1 |
| Bhadada, SV; Ghate, MD; Patel, BD | 1 |
| Akhtar, S; Benter, IF; Dahly-Vernon, AJ; Dunn, KM; Roman, RJ; Yousif, MH | 1 |
| Eiermann, GJ; Feng, Y; Howard, AD; Li, C; Li, Z; Mu, J; Petrov, A; Roy, RS; Thornberry, NA; Woods, J; Zhang, BB; Zhou, YP; Zhu, L; Zycband, E | 1 |
| Drucker, DJ; Hansotia, T; Longuet, C; Maida, A; Seino, Y | 1 |
| D'Alessio, D; Jessen, L | 1 |
| Ban, K; Drucker, DJ; Henkelman, RM; Husain, M; Momen, MA; Sauvé, M; Zhou, YQ | 1 |
| Bhalodia, Y; Manek, R; Sheth, N; Vaghasiya, J | 1 |
| Guarro, J; Mayayo, E; Pastor, FJ; Pujol, I; Ruíz-Cendoya, M; Sutton, DA | 1 |
| Flynn, ER; Manigrasso, MB; Marbury, DC; Maric, C; Sawyer, RT | 1 |
| Jung, HS; Kim, JH; Kim, KW; Kim, SK; Kim, YS; Lee, MK; Lee, MS; No, H; Oh, BJ; Oh, SH; Park, KS | 1 |
| Cho, JH; Ham, DS; Kim, ES; Kim, JW; Park, HS; Sun, C; Yeom, JA; Yoon, KH | 1 |
| Ambrósio, AF; Fernandes, R; Gonçalves, A; Leal, E; Paiva, A; Reis, F; Ribeiro, CF; Teixeira Lemos, E; Teixeira, F | 1 |
| Brubaker, PL; Grieco, A; Iakoubov, R; Lauffer, LM; Sangle, GV; Trivedi, S | 1 |
| Flynn, ER; Hutchens, ZM; Manigrasso, MB; Maric-Bilkan, C; Sawyer, RT | 1 |
| Allister, EM; Bhattacharjee, A; Wheeler, MB | 1 |
| Cheetham, S; Francis, J; Kirby, M; Poucher, SM; Vickers, SP; Zinker, B | 1 |
| Belavagi, NS; Gong, YD; Kalashetti, MB; Khan, AY; Khazi, IA; Mohammed Iqbal, AK | 1 |
| Burgmaier, M; Esser, M; Liberman, A; Ludwig, A; Marx, N; Ostertag, R; Vasic, D; Vittone, F; Walcher, D | 1 |
| Gupta, M; Kaur, P; Kumar, M; Sharma, M; Singh, D | 1 |
| Fan, K; Hou, J; Jin, W; Ma, J; Tan, Y; Wu, J; Xiao, W; Yu, B; Zheng, D | 1 |
| Advani, A; Advani, SL; Connelly, KA; Gilbert, RE; Thai, K; Yuen, DA; Zhang, Y | 1 |
| Chen, M; Guo, Z; Hao, J; Houze, J; Lin, DC; Lopez, E; Luo, J; Ma, Z; Nguyen, K; Rulifson, IC; Tian, B; Tian, L; Tran, T; Wang, Y; Zhang, Y | 1 |
| Badole, SL; Bagul, PP; Bodhankar, SL; Coutinho, EC; Ghule, AE; Joshi, AC; Khedkar, VM; Khose, RD; Mahamuni, SP; Raut, CG; Wagh, NK | 1 |
| DeRuyter, B; Guo, Z; Holstein, M; Lu, Y; Rabinovitch, A | 1 |
| Arun, KH; Kaul, CL; Kumar, S; Sharma, SS | 1 |
| Akhtar, S; Benter, IF; Canatan, H; Yousif, MH | 1 |
| Doudet, DJ; Kim, SJ; McIntosh, CH; Nian, C | 1 |
| Bachy, A; Fraisse, L; Herbert, JM; Keane, PE; Lale, A; Laplace, MC; Lassalle, J; Roche, B; Savi, P; Valette, G | 1 |
| Egan, JJ; Kochakian, M; Manjula, BN | 1 |
| de la Cruz, JP; García-Campos, J; Moreno, A; Ruiz-Ruiz, MI; Sánchez de la Cuesta, F | 1 |
| Hall, IH; Izydore, RA; Simlot, R; Wong, OT | 1 |
| Fisher, MA; Lee, PG; Tarry, WF | 1 |
| Boura, AL; Hodgson, WC; King, RG | 1 |
| Anantanarayanan, KG; Deliwala, CV; Mhasalkar, MY; Nikam, ST; Shah, MH | 1 |
74 other study(ies) available for triazoles and Alloxan Diabetes
| Article | Year |
|---|---|
Activation of HIF1α Rescues the Hypoxic Response and Reverses Metabolic Dysfunction in the Diabetic Heart.
Topics: Adaptation, Physiological; Anemia, Sickle Cell; Animals; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Energy Metabolism; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin Resistance; Myocytes, Cardiac; Oxygen; Pluripotent Stem Cells; Pyrazoles; Rats; Triazoles | 2021 |
Click inspired novel pyrazole-triazole-persulfonimide & pyrazole-triazole-aryl derivatives; Design, synthesis, DPP-4 inhibitor with potential anti-diabetic agents.
Topics: Animals; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Drug Design; Hypoglycemic Agents; Mice; Molecular Docking Simulation; Protease Inhibitors; Pyrazoles; Structure-Activity Relationship; Triazoles | 2022 |
EW-7197 Attenuates the Progression of Diabetic Nephropathy in db/db Mice through Suppression of Fibrogenesis and Inflammation.
Topics: Aniline Compounds; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Inflammation; Mice; Triazoles | 2022 |
Discovery of triazole tethered thymol/carvacrol-coumarin hybrids as new class of α-glucosidase inhibitors with potent in vivo antihyperglycemic activities.
Topics: alpha-Glucosidases; Animals; Blood Glucose; Coumarins; Diabetes Mellitus, Experimental; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Mice; Molecular Docking Simulation; Rats; Thymol; Triazoles | 2024 |
Discovery of LY3325656: A GPR142 agonist suitable for clinical testing in human.
Topics: Animals; Benzamides; Diabetes Mellitus, Experimental; Dogs; Drug Discovery; Drug Evaluation, Preclinical; Gene Knockout Techniques; Humans; Hypoglycemic Agents; Mice, Knockout; Molecular Structure; Rats; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Triazoles | 2020 |
The oral hypoxia-inducible factor prolyl hydroxylase inhibitor enarodustat counteracts alterations in renal energy metabolism in the early stages of diabetic kidney disease.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Energy Metabolism; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxygenases; Mice; N-substituted Glycines; Prolyl-Hydroxylase Inhibitors; Pyridines; Rats; Triazoles | 2020 |
A protective role of Gαq-RGS2 loop activator on streptozotocin induced diabetic complications in rats: An independent on elevated serum glucose level modulation.
Topics: Animals; Blood Glucose; Blood Vessels; Diabetes Mellitus, Experimental; GTP-Binding Protein alpha Subunits, Gq-G11; Hypertension; Male; Rats; Rats, Wistar; RGS Proteins; Triazoles | 2018 |
Discovery of triazole-based uracil derivatives bearing amide moieties as novel dipeptidyl peptidase-IV inhibitors.
Topics: Amides; Animals; Area Under Curve; Binding Sites; Catalytic Domain; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Hypoglycemic Agents; Inhibitory Concentration 50; Isoenzymes; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Molecular Docking Simulation; ROC Curve; Structure-Activity Relationship; Triazoles; Uracil | 2017 |
The BET/BRD inhibitor JQ1 attenuates diabetes-induced cognitive impairment in rats by targeting Nox4-Nrf2 redox imbalance.
Topics: Animals; Azepines; Cell Line; Cognition; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Hippocampus; Male; NADPH Oxidase 4; NF-E2-Related Factor 2; Oxidation-Reduction; Oxidative Stress; Rats, Wistar; Triazoles | 2018 |
(-)-Epicatechin and its metabolites prevent palmitate-induced NADPH oxidase upregulation, oxidative stress and insulin resistance in HepG2 cells.
Topics: Acetophenones; Animals; Benzoxazoles; Catechin; Diabetes Mellitus, Experimental; Diet, High-Fat; Enzyme Inhibitors; Hep G2 Cells; Humans; Insulin Resistance; Male; Mice, Inbred C57BL; NADPH Oxidase 4; NADPH Oxidases; Oxidative Stress; Palmitates; Signal Transduction; Triazoles; Up-Regulation | 2018 |
TSPA as a novel ATF6α translocation inducer efficiently ameliorates insulin sensitivity restoration and glucose homeostasis in db/db mice.
Topics: Acetamides; Activating Transcription Factor 6; Animals; Cell Line, Tumor; Cell Nucleus; Diabetes Mellitus, Experimental; Endoplasmic Reticulum; Glucose; Homeostasis; Humans; Insulin Resistance; Male; Mice; p38 Mitogen-Activated Protein Kinases; Protein Transport; Proto-Oncogene Proteins c-akt; Pyrazoles; Signal Transduction; Transcription Factor CHOP; Triazoles; Tunicamycin; X-Box Binding Protein 1 | 2018 |
BET-inhibition by JQ1 alleviates streptozotocin-induced diabetic cardiomyopathy.
Topics: Animals; Azepines; Caveolin 1; Cell Differentiation; Cell Movement; Cell Proliferation; Collagen; Cytoprotection; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Fibrosis; Male; Mice; Myocytes, Cardiac; Myofibroblasts; Proteins; Signal Transduction; Streptozocin; Transforming Growth Factor beta1; Triazoles; Ventricular Remodeling | 2018 |
Analgesic effects of ASP3662, a novel 11β-hydroxysteroid dehydrogenase 1 inhibitor, in rat models of neuropathic and dysfunctional pain.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Administration, Oral; Analgesics; Animals; Benzamides; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; Male; Pain; Rats; Rats, Sprague-Dawley; Streptozocin; Structure-Activity Relationship; Triazoles | 2018 |
Small molecule inhibition of dipeptidyl peptidase-4 enhances bone marrow progenitor cell function and angiogenesis in diabetic wounds.
Topics: Animals; Chemokine CXCL12; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Glipizide; Hematopoietic Stem Cells; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Triazoles; Wound Healing; Wounds and Injuries | 2019 |
Increase of late sodium current contributes to enhanced susceptibility to atrial fibrillation in diabetic mice.
Topics: Action Potentials; Animals; Atrial Fibrillation; Diabetes Mellitus, Experimental; Electrophysiological Phenomena; Male; Mice; Mice, Inbred C57BL; Pyridines; Sodium; Sodium Channel Blockers; Triazoles | 2019 |
Synthesis and evaluation of 1,ω-bis(1,2,3,5-thiatriazol-5-yl)alkanes as in vitro and in vivo α-amylase and lipase inhibitors.
Topics: Alkanes; alpha-Amylases; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Kidney; Lipase; Lipid Metabolism; Liver; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Triazoles | 2013 |
Oral L-glutamine increases active GLP-1 (7-36) amide secretion and improves glycemic control in stretpozotocin-nicotinamide induced diabetic rats.
Topics: Administration, Oral; Animals; Blood Glucose; Body Weight; Colon; Diabetes Mellitus, Experimental; Drinking; Gene Expression Regulation; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; Glutamine; Glycated Hemoglobin; Insulin; Lipid Metabolism; Male; Molecular Docking Simulation; Niacinamide; Oxidative Stress; Pancreas; Peptide Fragments; Protein Conformation; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Sitagliptin Phosphate; Triazoles | 2013 |
Effect of combined therapy of human Wharton's jelly-derived mesenchymal stem cells from umbilical cord with sitagliptin in type 2 diabetic rats.
Topics: Animals; C-Peptide; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucagon; Glycated Hemoglobin; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Pyrazines; Rats; Rats, Wistar; Sitagliptin Phosphate; Streptozocin; Treatment Outcome; Triazoles; Umbilical Cord | 2014 |
The effect of dipeptidyl peptidase-IV inhibition on bone in a mouse model of type 2 diabetes.
Topics: Animals; Blood Glucose; Body Weight; Bone and Bones; Cell Differentiation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Histocytochemistry; Male; Mice; Osteoblasts; Polymerase Chain Reaction; RNA; Triazoles; X-Ray Microtomography | 2014 |
Effect of concomitant administration of L-glutamine and cycloart-23-ene-3β, 25-diol (B2) with sitagliptin in GLP-1 (7-36) amide secretion, biochemical and oxidative stress in streptozotocin - nicotinamide induced diabetic Sprague Dawley rats.
Topics: Animals; Biomarkers; Blood Glucose; Body Weight; Colon; Diabetes Mellitus, Experimental; Drinking Behavior; Feeding Behavior; Glucagon-Like Peptide 1; Glutamine; Glycated Hemoglobin; Insulin; Lipid Metabolism; Male; Niacinamide; Oxidative Stress; Pancreas; Pyrazines; Rats; Rats, Sprague-Dawley; Sitagliptin Phosphate; Staining and Labeling; Streptozocin; Triazoles; Triterpenes | 2013 |
Effect of sitagliptin on the working memory and reference memory in type 2 diabetic Sprague-Dawley rats: possible role of adiponectin receptors 1.
Topics: Acetylcholine; Adiponectin; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Hypothalamus; Insulin; Lipids; Male; Memory; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Adiponectin; Sitagliptin Phosphate; Triazoles | 2013 |
Characterization of the exocrine pancreas in the male Zucker diabetic fatty rat model of type 2 diabetes mellitus following 3 months of treatment with sitagliptin.
Topics: Administration, Oral; Animals; Blood Glucose; Body Weight; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Hypoglycemic Agents; Keratins; Ki-67 Antigen; Male; Metformin; Pancreas, Exocrine; Pyrazines; Rats; Rats, Zucker; Sitagliptin Phosphate; Triazoles | 2014 |
Questions on therapy with DPP-4 inhibitors and bone homeostasis.
Topics: Animals; Bone and Bones; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Male; Osteoblasts; Triazoles | 2014 |
Dipeptidyl peptidase-IV inhibition prevents blood-retinal barrier breakdown, inflammation and neuronal cell death in the retina of type 1 diabetic rats.
Topics: Animals; Apoptosis; Biomarkers; Blood-Retinal Barrier; Blotting, Western; Cell Death; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Retinopathy; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Enzyme-Linked Immunosorbent Assay; Immunoenzyme Techniques; Inflammation; Male; Neurons; Pyrazines; Rats; Rats, Wistar; Retina; Sitagliptin Phosphate; Triazoles | 2014 |
Comparative activity of proline-containing dipeptide noopept and inhibitor of dipeptidyl peptidase-4 sitagliptin in a rat model of developing diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Proline; Pyrazines; Rats; Rats, Wistar; Sitagliptin Phosphate; Triazoles | 2014 |
Sitagliptin prevents inflammation and apoptotic cell death in the kidney of type 2 diabetic animals.
Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Glucagon-Like Peptide 1; Inflammation; Kidney; Pyrazines; Rats; Rats, Zucker; Sitagliptin Phosphate; Triazoles; Tumor Necrosis Factor-alpha | 2014 |
DPP IV inhibitor treatment attenuates bone loss and improves mechanical bone strength in male diabetic rats.
Topics: Animals; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Compressive Strength; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Drug Evaluation, Preclinical; Male; Pyrazines; Rats; Rats, Wistar; Sitagliptin Phosphate; Streptozocin; Stress, Mechanical; Triazoles | 2014 |
Noopept normalizes parameters of the incretin system in rats with experimental diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dipeptides; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Drug Evaluation, Preclinical; Glucagon-Like Peptide 1; Hypoglycemic Agents; Incretins; Insulin; Male; Pancreas; Pyrazines; Rats, Wistar; Sitagliptin Phosphate; Triazoles | 2014 |
HIS-388, a novel orally active and long-acting 11β-hydroxysteroid dehydrogenase type 1 inhibitor, ameliorates insulin sensitivity and glucose intolerance in diet-induced obesity and nongenetic type 2 diabetic murine models.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adamantane; Administration, Oral; Animals; Azepines; Carbenoxolone; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Female; Glucose Intolerance; Humans; Hypoglycemic Agents; Insulin Resistance; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Obesity; Pioglitazone; Thiazolidinediones; Triazoles | 2014 |
Left ventricular diastolic dysfunction and myocardial stiffness in diabetic mice is attenuated by inhibition of dipeptidyl peptidase 4.
Topics: Animals; Atrial Natriuretic Factor; Compliance; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diabetes Mellitus, Experimental; Diastole; Dipeptidyl-Peptidase IV Inhibitors; Drug Evaluation, Preclinical; Heart; Heart Ventricles; Male; Mice; Myocytes, Cardiac; Pyrazines; Random Allocation; Sitagliptin Phosphate; Triazoles; Ventricular Dysfunction, Left | 2014 |
Selective inhibition of NADPH oxidase reverses the over contraction of diabetic rat aorta.
Topics: Animals; Aorta; Benzoxazoles; Diabetes Mellitus, Experimental; Male; NADPH Oxidases; Phenylephrine; Rats; Rats, Wistar; Triazoles; Vasoconstriction | 2014 |
Plasma gelsolin levels decrease in diabetic state and increase upon treatment with F-actin depolymerizing versions of gelsolin.
Topics: Actins; Adult; Animals; Biomarkers; Blood Glucose; Case-Control Studies; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Down-Regulation; Female; Gelsolin; Humans; Hypoglycemic Agents; Male; Mice; Mice, Inbred C57BL; Peptide Fragments; Polymerization; Pyrazines; Recombinant Proteins; Sitagliptin Phosphate; Streptozocin; Time Factors; Triazoles | 2014 |
Sitagliptin attenuates transient cerebral ischemia/reperfusion injury in diabetic rats: implication of the oxidative-inflammatory-apoptotic pathway.
Topics: Animals; Brain Ischemia; Caspase 3; Cytochromes c; Diabetes Complications; Diabetes Mellitus, Experimental; Hippocampus; Hypoglycemic Agents; Interleukin-10; Male; Neuroprotective Agents; Neutrophil Infiltration; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury; Sitagliptin Phosphate; Triazoles | 2015 |
Synthesis, Antimicrobial and Hypoglycemic Activities of Novel N-(1-Adamantyl)carbothioamide Derivatives.
Topics: Adamantane; Animals; Anti-Bacterial Agents; Candida albicans; Diabetes Mellitus, Experimental; Gram-Negative Bacteria; Gram-Positive Bacteria; Hydrazines; Hypoglycemic Agents; Isothiocyanates; Male; Microbial Sensitivity Tests; Rats; Rats, Sprague-Dawley; Triazoles | 2015 |
Rufinamide Improves Functional and Behavioral Deficits via Blockade of Tetrodotoxin-Resistant Sodium Channels in Diabetic Neuropathy.
Topics: Animals; Biophysical Phenomena; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Ganglia, Spinal; Mental Disorders; Neural Conduction; Neurons; Patch-Clamp Techniques; Rats; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Triazoles | 2015 |
Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat-Fed Diabetic Mice.
Topics: Animals; Cardiomegaly; Cytokines; Diabetes Mellitus, Experimental; Diet, High-Fat; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Fibrosis; Heart; Heart Failure; Hypoglycemic Agents; Immunoblotting; Inflammation; Liraglutide; Mice; Mice, Knockout; Myocardium; RNA, Messenger; Transcriptome; Triazoles; Ventricular Function; Ventricular Remodeling | 2016 |
Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice.
Topics: Alginates; Animals; Blood Glucose; Blotting, Western; C-Peptide; Cell Culture Techniques; Cell Differentiation; Cell Transplantation; Chromatography, Liquid; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Embryonic Stem Cells; Flow Cytometry; Fluorescent Antibody Technique; Foreign-Body Reaction; Humans; Hydrogels; Immunocompetence; Insulin; Insulin-Secreting Cells; Mice; Microscopy, Confocal; Microscopy, Phase-Contrast; Morpholines; Polymers; Tandem Mass Spectrometry; Triazoles | 2016 |
Identification of 1,2,3-triazole derivatives that protect pancreatic β cells against endoplasmic reticulum stress-mediated dysfunction and death through the inhibition of C/EBP-homologous protein expression.
Topics: Animals; Blood Glucose; Cell Death; Cell Line; Cell Survival; Diabetes Mellitus, Experimental; Down-Regulation; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; HEK293 Cells; Humans; Hypoglycemic Agents; Insulin-Secreting Cells; Mice; Mice, Inbred C57BL; Protective Agents; RNA, Messenger; Transcription Factor CHOP; Triazoles; Up-Regulation | 2016 |
Discovery and development of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists for the treatment of diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Discovery; Glucose Tolerance Test; Mice; Mice, Knockout; Molecular Structure; Oxazepines; Rats; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Triazoles | 2016 |
Timed Inhibition of Orexin System by Suvorexant Improved Sleep and Glucose Metabolism in Type 2 Diabetic db/db Mice.
Topics: Adipose Tissue; Animals; Azepines; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Energy Metabolism; Glucagon; Glucose; Hypoglycemic Agents; Liver; Male; Mice; Mice, Inbred C57BL; Orexin Receptor Antagonists; Orexins; Receptors, Leptin; Sleep; Triazoles; Triglycerides; Wakefulness | 2016 |
Design, synthesis and anti-diabetic activity of triazolotriazine derivatives as dipeptidyl peptidase-4 (DPP-4) inhibitors.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Drug Design; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Triazines; Triazoles | 2017 |
Role of 20-hydroxyeicosatetraenoic acid in altering vascular reactivity in diabetes.
Topics: Amidines; Angiotensin II; Animals; Blood Glucose; Body Weight; Carbachol; Cytochrome P-450 CYP4A; Diabetes Mellitus, Experimental; Endothelin-1; Enzyme Inhibitors; Histamine; Hydroxyeicosatetraenoic Acids; Kidney; Male; Mesenteric Arteries; Microsomes; Nitroprusside; Norepinephrine; Perfusion; Rats; Rats, Wistar; Renal Artery; Triazoles; Vasoconstriction; Vasodilation | 2009 |
Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Fats; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Glipizide; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Ki-67 Antigen; Lipids; Liver; Male; Mice; Mice, Inbred ICR; Organ Size; Pyrazines; Sitagliptin Phosphate; Triazoles; Triglycerides | 2009 |
Differential importance of glucose-dependent insulinotropic polypeptide vs glucagon-like peptide 1 receptor signaling for beta cell survival in mice.
Topics: Animals; Apoptosis; Blood Glucose; Caspase 3; Cell Line; Cell Proliferation; Cell Survival; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide-1 Receptor; Glycated Hemoglobin; Hypoglycemic Agents; Incretins; Insulin; Insulin-Secreting Cells; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Peptides; Pyrazines; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Signal Transduction; Sitagliptin Phosphate; Time Factors; Triazoles; Venoms | 2009 |
The incretins and beta-cell health: contrasting glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 as a path to understand islet function in diabetes.
Topics: Animals; Blood Glucose; Cell Proliferation; Cell Survival; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide-1 Receptor; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Incretins; Insulin; Insulin-Secreting Cells; Mice; Peptides; Pyrazines; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Signal Transduction; Sitagliptin Phosphate; Triazoles; Venoms | 2009 |
Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes after myocardial infarction in mice.
Topics: Animals; Cardiovascular System; Coronary Vessels; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Gene Deletion; Heart; Hypoglycemic Agents; Male; Metformin; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Myocardial Ischemia; Pyrazines; Reference Values; Reperfusion; Sitagliptin Phosphate; Survivors; Triazoles | 2010 |
Sitagliptin protects renal ischemia reperfusion induced renal damage in diabetes.
Topics: Animals; Apoptosis; Catalase; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; DNA Fragmentation; Female; Glutathione; Glutathione Peroxidase; Kidney; Kidney Diseases; Lipid Peroxidation; Male; Oxidative Stress; Peroxidase; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury; Sitagliptin Phosphate; Superoxide Dismutase; Triazoles; Xanthine Oxidase | 2011 |
In vitro and in vivo antifungal susceptibilities of the Mucoralean fungus Cunninghamella.
Topics: Amphotericin B; Animals; Antifungal Agents; Caspofungin; Cunninghamella; Diabetes Mellitus, Experimental; Echinocandins; Itraconazole; Lipopeptides; Male; Mice; Microbial Sensitivity Tests; Mucormycosis; Pyrimidines; Thiazoles; Triazoles; Voriconazole | 2010 |
Inhibition of estradiol synthesis attenuates renal injury in male streptozotocin-induced diabetic rats.
Topics: Acute Kidney Injury; Albuminuria; Anastrozole; Animals; Aromatase Inhibitors; Collagen Type IV; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Estradiol; Interleukin-6; Male; Nitriles; Rats; Rats, Sprague-Dawley; Streptozocin; Testosterone; Transforming Growth Factor beta; Triazoles | 2011 |
Improved outcome of islet transplantation in partially pancreatectomized diabetic mice by inhibition of dipeptidyl peptidase-4 with sitagliptin.
Topics: Animals; Apoptosis; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Glucagon-Like Peptide 1; Insulin-Secreting Cells; Islets of Langerhans Transplantation; Male; Mice; Mice, Inbred C57BL; Pancreatectomy; Pyrazines; Sitagliptin Phosphate; Triazoles | 2011 |
Both sitagliptin analogue & pioglitazone preserve the beta-cell proportion in the islets with different mechanism in non-obese and obese diabetic mice.
Topics: Animals; Apoptosis; Blood Glucose; Body Weight; Cell Proliferation; Diabetes Mellitus, Experimental; Fasting; Glucose Tolerance Test; Homeostasis; Insulin-Secreting Cells; Ki-67 Antigen; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Organ Size; Pioglitazone; Pyrazines; Sitagliptin Phosphate; Thiazolidinediones; Triazoles | 2011 |
Protective effects of the dipeptidyl peptidase IV inhibitor sitagliptin in the blood-retinal barrier in a type 2 diabetes animal model.
Topics: Animals; Apoptosis; Blood-Retinal Barrier; Blotting, Western; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Dipeptidyl-Peptidase IV Inhibitors; Glycated Hemoglobin; Immunohistochemistry; In Situ Nick-End Labeling; Male; Pyrazines; Rats; Rats, Zucker; Sitagliptin Phosphate; Triazoles | 2012 |
Novel biological action of the dipeptidylpeptidase-IV inhibitor, sitagliptin, as a glucagon-like peptide-1 secretagogue.
Topics: Animals; Animals, Newborn; Cell Line; Cyclic AMP; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Exenatide; Extracellular Signal-Regulated MAP Kinases; Glucagon-Like Peptide 1; Humans; Ionomycin; Mice; Molecular Structure; Peptides; Pyrazines; Rats; Rats, Wistar; Sitagliptin Phosphate; Triazoles; Venoms | 2012 |
Combined inhibition of aromatase activity and dihydrotestosterone supplementation attenuates renal injury in male streptozotocin (STZ)-induced diabetic rats.
Topics: Albuminuria; Anastrozole; Animals; Aromatase; Aromatase Inhibitors; Collagen Type IV; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dietary Supplements; Dihydrotestosterone; Disease Models, Animal; Estrogen Receptor alpha; Incidence; Male; Nitriles; Rats; Rats, Sprague-Dawley; Receptors, Androgen; Streptozocin; Triazoles; Tumor Necrosis Factor-alpha | 2012 |
MK-626, a dipeptidyl peptidase-4 inhibitor, does not improve the hyperglycemia or hyperinsulinemia of nonobese diabetic MKR mice.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Glucagon; Glucose; Glucose Intolerance; Homeostasis; Hyperglycemia; Hyperinsulinism; Incretins; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Obese; Phenylalanine; Triazoles | 2012 |
Effects of saxagliptin and sitagliptin on glycaemic control and pancreatic β-cell mass in a streptozotocin-induced mouse model of type 2 diabetes.
Topics: Adamantane; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Dipeptides; Drinking; Eating; Glucose Tolerance Test; Glycated Hemoglobin; Hypoglycemic Agents; Immunohistochemistry; Insulin-Secreting Cells; Male; Mice; Mice, Inbred C57BL; Pyrazines; Sitagliptin Phosphate; Triazoles | 2012 |
Synthesis, hypoglycemic and hypolipidemic activities of novel thiazolidinedione derivatives containing thiazole/triazole/oxadiazole ring.
Topics: Animals; Chemistry Techniques, Synthetic; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Hypolipidemic Agents; Male; Oxadiazoles; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Triazoles | 2012 |
Sitagliptin reduces plaque macrophage content and stabilises arteriosclerotic lesions in Apoe (-/-) mice.
Topics: Animals; Apolipoproteins E; Arteriosclerosis; Body Weight; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Glucagon-Like Peptide 1; Immunohistochemistry; Lipid Metabolism; Macrophages; Male; Mice; Mice, Inbred C57BL; Pyrazines; Sitagliptin Phosphate; Triazoles | 2012 |
Synthesis, evaluation and molecular docking of thiazolopyrimidine derivatives as dipeptidyl peptidase IV inhibitors.
Topics: Animals; Binding Sites; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Hypoglycemic Agents; Male; Molecular Docking Simulation; Protein Structure, Tertiary; Pyrimidines; Rats; Rats, Wistar; Structure-Activity Relationship; Triazoles | 2012 |
Combination of mangiferin and dipeptidyl peptidase-4 inhibitor sitagliptin improves impaired glucose tolerance in streptozotocin-diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Glucagon-Like Peptide 1; Glucose Intolerance; Insulin; Islets of Langerhans; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Sitagliptin Phosphate; Streptozocin; Triazoles; Xanthones | 2012 |
DPP-4 inhibition attenuates cardiac dysfunction and adverse remodeling following myocardial infarction in rats with experimental diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Heart; Myocardial Infarction; Pyrazines; Rats; Rats, Inbred F344; Sitagliptin Phosphate; Streptozocin; Triazoles; Ventricular Remodeling | 2013 |
Evaluating insulin secretagogues in a humanized mouse model with functional human islets.
Topics: Animals; Blood Glucose; Cyclohexanes; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Exenatide; Glucagon-Like Peptide 1; Glucose Tolerance Test; Glyburide; Humans; Incretins; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Mice; Mice, Nude; Nateglinide; Peptides; Phenylalanine; Pyrazines; Sitagliptin Phosphate; Specific Pathogen-Free Organisms; Triazoles; Venoms | 2013 |
Cycloart-23-ene-3β, 25-diol stimulates GLP-1 (7-36) amide secretion in streptozotocin-nicotinamide induced diabetic Sprague Dawley rats: a mechanistic approach.
Topics: Animals; Biomarkers; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Drinking; Gene Expression Regulation; Glucagon-Like Peptide 1; Glucose Tolerance Test; Insulin; Male; Molecular Docking Simulation; Niacinamide; Oxidative Stress; Pancreas; Peptide Fragments; Protein Conformation; Pyrazines; Rats; Rats, Sprague-Dawley; Sitagliptin Phosphate; Time Factors; Triazoles; Triterpenes | 2013 |
Stimulating β-cell regeneration by combining a GPR119 agonist with a DPP-IV inhibitor.
Topics: Acids, Heterocyclic; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Glucagon-Like Peptide 1; Humans; Insulin-Secreting Cells; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Oxadiazoles; Pyrazines; Receptors, G-Protein-Coupled; Regeneration; Sitagliptin Phosphate; Triazoles | 2013 |
Effects of adenosine and adenosine A2A receptor agonist on motor nerve conduction velocity and nerve blood flow in experimental diabetic neuropathy.
Topics: Adenosine; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Neural Conduction; Phenethylamines; Purinergic P2 Receptor Agonists; Rats; Regional Blood Flow; Sciatic Nerve; Staining and Labeling; Streptozocin; Theophylline; Time Factors; Triazines; Triazoles | 2005 |
Inhibition of Ca2+/calmodulin-dependent protein kinase II, RAS-GTPase and 20-hydroxyeicosatetraenoic acid attenuates the development of diabetes-induced vascular dysfunction in the rat carotid artery.
Topics: Amidines; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carotid Arteries; Carotid Artery Diseases; Diabetes Mellitus, Experimental; Hydroxyeicosatetraenoic Acids; Monomeric GTP-Binding Proteins; Organophosphonates; Protein Kinase Inhibitors; Rats; Rats, Wistar; Streptozocin; Sulfonamides; Triazoles; Vascular Diseases; Vasoconstriction; Vasodilation | 2005 |
Inhibition of dipeptidyl peptidase IV with sitagliptin (MK0431) prolongs islet graft survival in streptozotocin-induced diabetic mice.
Topics: Animals; Blood Glucose; Cell Culture Techniques; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Graft Survival; Hypoglycemic Agents; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Mice; Mice, Inbred C57BL; Pyrazines; Sitagliptin Phosphate; Triazoles | 2008 |
Biochemical and pharmacological properties of SR 27388, a dual antioxidant and PAF receptor antagonist.
Topics: Animals; Antioxidants; Azepines; Blood Glucose; Blood Platelets; Cattle; Diabetes Mellitus, Experimental; Free Radical Scavengers; Humans; Lipid Peroxidation; Male; Mice; Mice, Inbred Strains; Mitochondria, Heart; Monocytes; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Shock, Septic; Superoxides; Sympathomimetics; Thiazoles; Thiobarbituric Acid Reactive Substances; Triazoles | 1993 |
Chronic dosing with aminoguanidine and novel advanced glycosylation end product-formation inhibitors ameliorates cross-linking of tail tendon collagen in STZ-induced diabetic rats.
Topics: Aminobenzoates; Animals; Benzoates; Collagen; Cross-Linking Reagents; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glycosylation; Guanidines; Hydroxybenzoates; Kinetics; Pepsin A; Rats; Rats, Inbred Lew; Solubility; Species Specificity; Tail; Tendons; Triazoles | 1996 |
Effect of WEB 2086-BS, an antagonist of platelet-activating factor receptors, on retinal vascularity in diabetic rats.
Topics: Analysis of Variance; Animals; Azepines; Blood Glucose; Blood Platelets; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Dose-Response Relationship, Drug; Epoprostenol; Lipid Peroxidation; Male; Neovascularization, Pathologic; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Retina; Thromboxane B2; Triazoles | 1998 |
Potential aldose reductase inhibitors: 1,2,4-triazolidine-3,5-diones and 2-(3,4,5-trimethoxybenzoyl)-4,4-diethyl-3,5-isoxazolidinedione .
Topics: Aldehyde Reductase; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Erythrocytes; Isoxazoles; Lens, Crystalline; Male; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Structure-Activity Relationship; Triazoles | 1992 |
Fluconazole (UK-49,858) treatment of candidiasis in normal and diabetic rats.
Topics: Amphotericin B; Animals; Antifungal Agents; Candidiasis; Diabetes Mellitus, Experimental; Fluconazole; Male; Microbial Sensitivity Tests; Rats; Rats, Inbred Strains; Saccharomyces cerevisiae; Triazoles | 1989 |
Changes in cardiovascular sensitivity of alloxan-treated diabetic rats to arachidonic acid.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Diabetes Mellitus, Experimental; Injections, Intra-Arterial; Injections, Intravenous; Male; Perfusion; Prostaglandin Endoperoxides, Synthetic; Rats; Triazoles | 1986 |
4-alkyl-5-aryl-4H-1,2,4-triazole-3-thiols as hypoglycemic agents.
Topics: Animals; Blood Glucose; Depression, Chemical; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Metabolism; Methods; Rats; Triazoles | 1970 |