triazoles has been researched along with Chronic Insomnia in 123 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (4.07) | 18.7374 |
| 1990's | 9 (7.32) | 18.2507 |
| 2000's | 4 (3.25) | 29.6817 |
| 2010's | 75 (60.98) | 24.3611 |
| 2020's | 30 (24.39) | 2.80 |
| Authors | Studies |
|---|---|
| Benca, R; Botteman, M; Kale, HP; Khandker, R; Meng, W; Qureshi, ZP; Shah, R | 1 |
| Bertisch, SM; Cohn, AY; Crawford, S; Erickson, A; Grant, LK; Harder, JA; Joffe, H; McCormick, K; Nathan, MD; Rahman, SA; Srivastava, A; Wiley, A; Winkelman, JW | 1 |
| Kaur, H; Krishnamurthy, VB; Singh, J; Yadav, S | 1 |
| Berger, AA; Gilbert, E; Hasoon, J; Kaye, AD; Keefe, J; Sottosanti, ER; Thase, ME; Urits, I; Viswanath, O; Winnick, A | 1 |
| Birku, K; Kobayashi, I; Lavela, P; Mellman, TA; Sandhu, I | 1 |
| Inamoto, A; Iwanami, A; Kondo, S; Okino, K; Suzuki, H; Tokumasu, T; Tomioka, H; Yamada, H | 1 |
| Kawada, T | 1 |
| Asai, Y; Hara, M; Iwakura, M; Maeda, Y; Miyazaki, M; Sano, H | 2 |
| Atkinson, R; Cheng, P; Cuamatzi-Castelan, A; Drake, CL; Fellman-Couture, C; Kalmbach, DA; Roth, T; Singh, M; Tonnu, CV; Tran, KM | 1 |
| Gamble, MC; Katsuki, F; McCoy, JG; McKenna, JT; Strecker, RE | 1 |
| Cardoso, R; Farah, B; Goodarzi, Z; Harricharan, S; Leech, J; Morin, CM; Morra, D; Nincic, V; Rios, P; Straus, SE; Tricco, AC | 1 |
| Asai, Y; Iwakura, M; Maeda, Y; Miyazaki, M; Sano, H; Takeuchi, Y | 1 |
| Bonomo, Y; Campbell, EJ; Lawrence, AJ; Norman, A | 1 |
| Herring, WJ; Lines, C; Roth, T; Snyder, ES; Svetnik, V; Tao, P | 1 |
| Bliwise, D; Budd, K; Ceesay, P; Herring, WJ; Hutzelmann, J; Lines, C; Michelson, D; Snyder, E; Stevens, J | 1 |
| Dauvilliers, Y; Fietze, I; Hedner, J; Mayleben, D; Pain, S; Seboek Kinter, D; Zammit, G | 1 |
| Bazan, L; Koshorek, G; Roehrs, T; Roth, T; Verkler, J; Withrow, D | 1 |
| Dauvilliers, Y; Kunz, D; Mansour, Y; Pain, S; Sebök Kinter, D; Zammit, G | 1 |
| Dujardin, S; Pevernagie, D; Pijpers, A | 1 |
| Molano, JRV | 1 |
| Adams, AD; Brown, JN; Pepin, MJ | 1 |
| Hernandez, B; Holty, JE; Joyce, DS; McBean, A; Quevedo, YL; Zeitzer, JM | 1 |
| Brian, ML; Clark, JW; Drummond, SPA; Hoyer, D; Jacobson, LH | 1 |
| Ikuta, T; Iwata, N; Kishi, T; Matsuda, Y; Nomura, I; Okuya, M; Sakuma, K | 1 |
| Earl, DC; Van Tyle, KM | 1 |
| Araki, T; Hashioka, S; Hayashida, M; Inagaki, M; Ito, T; Izuhara, HK; Izuhara, M; Kimura, T; Miura, S; Nagahama, M; Otsuki, K; Saito, Y; Sato, K; Tsuchie, K; Tsumoto, S; Wake, R | 1 |
| Murata, T | 1 |
| Hashioka, S; Inagaki, M; Izuhara, M; Kawano, K; Otsuki, K | 1 |
| Arai, T; Ichida, M; Inada, T; Kojima, S; Naito, K; Ozaki, N; Tachibana, M | 1 |
| Matsumoto, T | 1 |
| Atkins, N; Citrome, L; Frech, F; Juday, T | 1 |
| Akiyama, M; Ishida, H; Kitahara, T; Kouda, K; Matsunaga, K; Saisyo, A; Takasago, M; Takasaki, A; Wakabayashi, K | 1 |
| Bliwise, D; Budd, K; Ceesay, P; Ceren, O; Herring, WJ; Hutzelmann, J; Lines, C; Michelson, D; Snyder, E; Stevens, J; Svetnik, V; Wang, TC | 1 |
| Kuriyama, A; Tabata, H | 1 |
| Benca, RM; Connor, KM; Herring, WJ; Hutzelmann, J; Krystal, AD; Lines, C; Matzura-Wolfe, D; Michelson, D; Roth, T; Snavely, DB; Snyder, E; Walsh, JK; Zhang, Y | 3 |
| Coleman, PJ; Fox, SV; Gotter, AL; Hodgson, R; Ramirez, AD; Renger, JJ; Roecker, AJ; Smith, SM; Uslaner, JM; Winrow, CJ; Yao, L | 1 |
| Horiuchi, F; Kawabe, K; Nishimoto, K; Ochi, M; Oka, Y; Ueno, SI | 1 |
| Hibino, H; Inoue, Y; Matsumoto, H; Mikami, A; Mikami, K; Suzuki, H | 3 |
| Bai, X; He, J; Li, T; Qiao, H; Xu, J; Ye, X; Zhang, J; Zhang, W | 1 |
| Nagamine, T; Nakamura, M | 1 |
| Hope, J; Keks, NA; Keogh, S | 1 |
| Furmaga, K; Petrous, J | 1 |
| Herring, WJ; Lines, C; Roth, T; Scammell, TE; Snyder, ES; Svetnik, V; Tao, P | 1 |
| Hamuro, A; Honda, M; Wakaura, Y | 1 |
| Nakao, M; Nishimura, S | 1 |
| Beneš, H; De Boer, P; Dorffner, G; Drevets, WC; Jahn, H; Keicher, C; Kent, JM; Kezic, I; Luthringer, R; Parapatics, S; Rofael, H; Seiden, DJ; van der Ark, P; van Gerven, J | 1 |
| Kawada, K; Miyamura, M; Ohta, T; Tanaka, K; Tanaka, S | 1 |
| Herring, WJ; Krystal, AD; Michelson, D; Roth, T | 1 |
| Nakamura, K; Yasui-Furukori, N; Yoshida, K | 1 |
| Cho, M; Honda, T; Kabashima, K; Komori, T; Otsuka, A | 1 |
| Connor, KM; Herring, WJ; Lines, C; Michelson, D; Morin, CM; Snavely, DB; Snyder, E | 1 |
| Brooks, S; de Boer, P; Drevets, W; Jacobs, GE; Kent, JM; Kezic, I; Luthringer, R; van Amerongen, G; van der Ark, P; van Gerven, JM; Van Nueten, L; Zuiker, R | 1 |
| Benedict, J; Ehlers, CL; Sanchez-Alavez, M; Wills, DN | 1 |
| Akihiro, S; Daida, H; Fujibayashi, K; Kasai, T; Matsumoto, H; Nishizaki, Y; Nojiri, S; Ogita, M; Ono, N; Shitara, J; Suda, S; Suwa, S; Yanagisawa, N; Yatsu, S | 1 |
| Doumas, M; Imprialos, KP; Karagiannis, A; Papademetriou, V; Stavropoulos, K | 1 |
| Kanegae, H; Kario, K; Okawara, Y; Tomitani, N; Tsukamoto, M; Yagi, K; Yamasaki, K; Yamazaki, S | 1 |
| Kinoshita, T; Koshikawa, K; Matsumura, T; Nagashima, K; Sakao, S; Tatsumi, K; Terada, J; Yahaba, M; Yoshimura, C | 1 |
| Yanagisawa, M | 1 |
| Connor, DF; Prieto, DI; Zehgeer, AA | 1 |
| Iwata, N; Kishi, T; Kubo, M; Matsui, Y; Matsunaga, S; Ninomiya, K; Nomura, I; Okuya, M; Okuyama, Y; Oya, K; Sakuma, K | 1 |
| Crow, JM | 1 |
| Czajkowska, B; Krzystanek, M; Lapray, D; Markowski, G; Pałasz, A; Peyron, C; Rojczyk-Gołębiewska, E; Skowronek, R; Wiaderkiewicz, R | 1 |
| Osborne, R | 1 |
| Badiger, S; Behnke, D; Betschart, C; Chaudhari, V; Cotesta, S; Fendt, M; Gee, CE; Hintermann, S; Hoyer, D; Jacobson, LH; Laue, G; Ofner, S; Pandit, C; Wagner, J | 1 |
| Hoyer, D; Jacobson, LH | 1 |
| Benca, RM; Chengan-Liu, M; Cohn, M; Herring, WJ; Hutzelmann, J; Krystal, AD; Lines, C; Michelson, D; Paradis, E; Roth, T; Snavely, DB; Snyder, E; Walsh, JK | 1 |
| Riemann, D; Spiegelhalder, K | 1 |
| Traynor, K | 1 |
| Herring, WJ; Lines, C; Ma, J; Roth, T; Snyder, E; Svetnik, V | 1 |
| Yang, LP | 1 |
| Citrome, L | 1 |
| Howland, RH | 1 |
| Sheridan, C | 1 |
| Callander, GE; Hoyer, D; Jacobson, LH | 1 |
| El-Mallakh, RS; Kommisetti, S; Lippmann, S; Puvvada, SC; Reddy, A | 1 |
| Benca, RM; Budd, K; Connor, KM; Froman, S; Herring, WJ; Hutzelmann, J; Ivgy-May, N; Krystal, AD; Leibensperger, H; Lines, C; Liu, K; Michelson, D; Rosenberg, R; Roth, T; Sangal, RB; Snavely, DB; Snyder, E; Walsh, JK | 1 |
| Kolb, P; Mobarec, JC; Rosenbaum, DM; Yin, J | 1 |
| Aspesi, AV; Evoy, KE; Patel, KV | 1 |
| Brownlow, JA; Harb, GC; Ross, RJ | 1 |
| Brunner, J; Bruno, JG; Cabalu, TD; Coleman, PJ; DiMarco, CN; Garson, SL; Gotter, AL; Harrell, CM; Kuduk, SD; O'Brien, JA; Pausch, MH; Renger, JJ; Savitz, AT; Skudlarek, JW; Stevens, J; Tannenbaum, PL; Winrow, CJ | 1 |
| Card, D; Gipson, A; Kryger, M; Lines, C; Palcza, J; Rosenberg, R; Sun, H; Troyer, MD; Wagner, JA | 1 |
| Iwata, N; Kishi, T; Matsunaga, S | 1 |
| Sutton, EL | 1 |
| Cabalu, T; Cui, D; Li, X; Liu, B; Liu, W; Maciolek, C; McCrea, JB; Prueksaritanont, T; Small, J; Smith, S; Yee, KL | 1 |
| Owen, RT | 1 |
| Connor, KM; Herring, WJ; Lines, C; Ma, J; Michelson, D; Snyder, E; Svetnik, V | 1 |
| Gauld, AR | 1 |
| Stahl, SM | 1 |
| Bautmans, A; Heirman, I; Jongen, S; Laethem, T; Li, X; McCrea, J; Palcza, J; Sun, H; Troyer, MD; Van Oers, AC; Vermeeren, A; Vets, E; Vuurman, EF; Wrishko, R | 1 |
| Aoki, I; Hisada, S; Ishine, T; Renger, JJ; Tanaka, Y; Winrow, CJ | 1 |
| Coleman, PJ; Gotter, AL; Herring, WJ; Renger, JJ; Winrow, CJ | 1 |
| Kitaguchi, H; Kuriyama, A; Shindo, K; Tabata, H; Yamao, F | 1 |
| Edmonds, C; Swanoski, M | 1 |
| Born, S; Briscoe, R; Gauvin, DV; Mukherjee, S | 1 |
| Anderson, WB; Bednar, RA; Bogusky, MJ; Breslin, MJ; Bruno, JG; Cabalu, TD; Coleman, PJ; Cox, CD; Cui, D; Doran, SM; Garson, SL; Harrell, CM; Hartman, GD; Koblan, KS; Lemaire, W; McGaughey, GB; Mercer, SP; Murphy, KL; Prueksaritanont, T; Reiss, DR; Renger, JJ; Roecker, AJ; Roller, S; Schreier, JD; Tang, C; Whitman, DB; Winrow, CJ; Young, SD | 1 |
| Ball, RG; Bednar, RA; Bogusky, MJ; Breslin, MJ; Cabalu, TD; Coleman, PJ; Cox, CD; Cui, D; Doran, SM; Fox, SV; Garson, SL; Gotter, AL; Harrell, CM; Hartman, GD; Lemaire, W; McGaughey, GB; Prueksaritanont, T; Reiss, DR; Renger, JJ; Schreier, JD; Stellabott, J; Stevens, J; Tannenbaum, PL; Whitman, DB; Winrow, CJ; Young, SD | 1 |
| Willyard, C | 1 |
| Hopkins, CR | 1 |
| Budd, K; Herring, WJ; Hutzelmann, J; Lines, C; Liu, K; Michelson, D; Roth, T; Snavely, D; Snyder, E | 1 |
| Galanakis, P; Schreiner, R; Wiegand, MH | 1 |
| Foster, G; Labadie, R; Liu, P; Sharma, A; Somoza, E | 1 |
| Imhof, A; Schaer, DJ; Schanz, U; Schwarz, U | 1 |
| Cepeda, C; Pérez-Toledo, MA; Romo, R; Velasco, F; Velasco, M | 1 |
| Nelson, JC | 1 |
| Case, WG; DeMartinis, N; Garcia España, FG; Greenblatt, DJ; Mandos, LA; Rickels, K; Schweizer, E | 1 |
| Albala, BJ; Armitage, R; Erman, MK; Fleming, JB; Gillin, JC; Kaplita, SB; McQuade, RD; Moldofsky, H; Montplaisir, J; Rush, AJ; Vogel, GW; Winokur, A; Yonkers, KA | 1 |
| Beckham, JC; Davidson, JR; Feldman, ME; Hertzberg, MA; Moore, SD | 1 |
| Berkowitz, DV; Conrad, C; McDannold, M; Scharf, MB; Spinner, O; Stover, R; Zaretsky, N | 1 |
| Thase, ME | 1 |
| Borian, FE; Dunner, DL; Friedman, ES; Keller, MB; Klein, DN; Kornstein, SG; Manber, R; Markowitz, JC; Ninan, PT; Rush, AJ; Schatzberg, AF; Thase, ME; Trivedi, MH | 1 |
| Edwards, K; Gibbons, P; Sexton, K; Sloan, KB; Thurmond, A; Vogel, G | 1 |
| Sunshine, A | 1 |
| Clark, EL; Gingrich, RL; Morris, RJ; Perloff, MM; Rickels, K; Rosenfeld, H; Schilling, A | 1 |
| Egilmez, S; Itil, TM; Marasa, J; Polvan, N; Saletu, B | 1 |
29 review(s) available for triazoles and Chronic Insomnia
| Article | Year |
|---|---|
Suvorexant in the Treatment of Difficulty Falling and Staying Asleep (Insomnia).
Topics: Adult; Azepines; Humans; Hypothalamo-Hypophyseal System; Pituitary-Adrenal System; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Triazoles | 2022 |
Comparative effectiveness and safety of pharmacological and non-pharmacological interventions for insomnia: an overview of reviews.
Topics: Antidepressive Agents; Antipsychotic Agents; Azepines; Benzodiazepines; Cognitive Behavioral Therapy; Comparative Effectiveness Research; Humans; Hypnotics and Sedatives; Melatonin; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Systematic Reviews as Topic; Triazoles; Zolpidem | 2019 |
Suvorexant to treat alcohol use disorder and comorbid insomnia: Plan for a phase II trial.
Topics: Alcoholism; Azepines; Benzodiazepines; Clinical Trials, Phase II as Topic; Comorbidity; Humans; Orexin Receptor Antagonists; Orexin Receptors; Sleep Initiation and Maintenance Disorders; Triazoles | 2020 |
Prescription Drugs Used in Insomnia.
Topics: Antipsychotic Agents; Azepines; Benzodiazepines; Humans; Melatonin; Orexin Receptor Antagonists; Prescription Drugs; Sleep; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Triazoles | 2020 |
The role of suvorexant in the prevention of delirium during acute hospitalization: A systematic review.
Topics: Aged; Aged, 80 and over; Azepines; Critical Care; Critical Illness; Delirium; Drug Therapy, Combination; Female; Humans; Indenes; Length of Stay; Male; Middle Aged; Orexin Receptor Antagonists; Randomized Controlled Trials as Topic; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Retrospective Studies; Sleep; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Triazoles | 2020 |
Effects of orexin receptor antagonism on human sleep architecture: A systematic review.
Topics: Azepines; Healthy Volunteers; Humans; Orexin Receptor Antagonists; Polysomnography; Sleep; Sleep Initiation and Maintenance Disorders; Sleep Stages; Sleep, REM; Triazoles | 2020 |
Lemborexant vs suvorexant for insomnia: A systematic review and network meta-analysis.
Topics: Azepines; Double-Blind Method; Female; Humans; Male; Middle Aged; Network Meta-Analysis; Pyridines; Pyrimidines; Randomized Controlled Trials as Topic; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Triazoles | 2020 |
New pharmacologic agents for insomnia and hypersomnia.
Topics: Azepines; Carbamates; Dementia; Disorders of Excessive Somnolence; GABA-A Receptor Agonists; Humans; Orexin Receptor Antagonists; Phenylalanine; Piperidines; Pyridines; Pyrimidines; Sleep Aids, Pharmaceutical; Sleep Apnea, Obstructive; Sleep Initiation and Maintenance Disorders; Trazodone; Triazoles; Zolpidem | 2020 |
Suvorexant for the treatment of primary insomnia: A systematic review and meta-analysis.
Topics: Azepines; Humans; Japan; Randomized Controlled Trials as Topic; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Triazoles; United States | 2017 |
Suvorexant: scientifically interesting, utility uncertain.
Topics: Azepines; Humans; Orexin Receptor Antagonists; Sleep Initiation and Maintenance Disorders; Triazoles | 2017 |
Orexin receptor antagonists for the treatment of insomnia and potential treatment of other neuropsychiatric indications.
Topics: Azepines; Female; Humans; Male; Neuropsychiatry; Orexin Receptor Antagonists; Sleep Initiation and Maintenance Disorders; Triazoles | 2019 |
Toward the Mysteries of Sleep.
Topics: Animals; Azepines; Cataplexy; Humans; Hypothalamus; Mice; Mice, Transgenic; Mutation; Narcolepsy; Nerve Tissue Proteins; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Polysomnography; Sleep; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Synapses; Triazoles; Wakefulness | 2019 |
Dual orexin receptor antagonists - promising agents in the treatment of sleep disorders.
Topics: Acetamides; Animals; Azepines; Benzofurans; Humans; Isoquinolines; Models, Biological; Orexin Receptor Antagonists; Orexin Receptors; Piperidines; Pyrimidines; Sleep; Sleep Initiation and Maintenance Disorders; Thiazoles; Triazoles; Wakefulness | 2014 |
Orexin in sleep, addiction and more: is the perfect insomnia drug at hand?
Topics: Acetamides; Animals; Azepines; Behavior, Addictive; Benzofurans; Feeding Behavior; Humans; Intracellular Signaling Peptides and Proteins; Isoquinolines; Mice; Neuropeptides; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Piperidines; Pyrimidines; Rats; Reward; Sleep; Sleep Initiation and Maintenance Disorders; Thiazoles; Triazoles | 2013 |
Suvorexant: first global approval.
Topics: Azepines; Drug Approval; Humans; Orexin Receptor Antagonists; Sleep Initiation and Maintenance Disorders; Triazoles | 2014 |
Suvorexant for insomnia: a systematic review of the efficacy and safety profile for this newly approved hypnotic - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed?
Topics: Azepines; Drug Administration Schedule; Humans; Hypnotics and Sedatives; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Triazoles | 2014 |
Suvorexant for the treatment of insomnia.
Topics: Adult; Aged; Animals; Azepines; Dose-Response Relationship, Drug; Drug Approval; Humans; Hypnotics and Sedatives; Orexin Receptor Antagonists; Sleep Initiation and Maintenance Disorders; Triazoles; United States; United States Food and Drug Administration | 2014 |
Suvorexant: a dual orexin receptor antagonist for the treatment of sleep onset and sleep maintenance insomnia.
Topics: Azepines; Humans; Hypnotics and Sedatives; Orexin Receptor Antagonists; Sleep; Sleep Initiation and Maintenance Disorders; Triazoles | 2015 |
Suvorexant (Belsomra) for insomnia.
Topics: Animals; Azepines; Clinical Trials as Topic; Humans; Orexin Receptor Antagonists; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Triazoles | 2015 |
Treatment of Sleep Disturbances in Post-Traumatic Stress Disorder: A Review of the Literature.
Topics: Antipsychotic Agents; Cognitive Behavioral Therapy; Dreams; Eye Movement Desensitization Reprocessing; Fluvoxamine; Humans; Piperazines; Prazosin; REM Sleep Behavior Disorder; Restless Legs Syndrome; Serotonin and Noradrenaline Reuptake Inhibitors; Sleep; Sleep Apnea, Obstructive; Sleep Initiation and Maintenance Disorders; Sleep Wake Disorders; Stress Disorders, Post-Traumatic; Trazodone; Triazoles | 2015 |
Suvorexant for Primary Insomnia: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials.
Topics: Azepines; Female; Humans; Male; Middle Aged; Randomized Controlled Trials as Topic; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Triazoles | 2015 |
Profile of suvorexant in the management of insomnia.
Topics: Azepines; Humans; Sleep Initiation and Maintenance Disorders; Triazoles | 2015 |
Suvorexant: efficacy and safety profile of a dual orexin receptor antagonist in treating insomnia.
Topics: Azepines; Clinical Trials as Topic; Drug Interactions; Humans; Orexin Receptor Antagonists; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Triazoles | 2016 |
Preclinical and clinical results of dual orexin receptor antagonist, suvorexant (BELSOMRA(®)), a novel therapeutic agent for insomnia.
Topics: Animals; Azepines; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Orexin Receptor Antagonists; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Triazoles | 2016 |
The Discovery of Suvorexant, the First Orexin Receptor Drug for Insomnia.
Topics: Animals; Azepines; Drug Discovery; Humans; Orexin Receptor Antagonists; Orexin Receptors; Protein Structure, Secondary; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Triazoles | 2017 |
A Review of Suvorexant, Doxepin, Ramelteon, and Tasimelteon for the Treatment of Insomnia in Geriatric Patients.
Topics: Aged; Aged, 80 and over; Azepines; Benzofurans; Cyclopropanes; Doxepin; Humans; Hypnotics and Sedatives; Indenes; Randomized Controlled Trials as Topic; Sleep Initiation and Maintenance Disorders; Triazoles | 2017 |
ACS chemical neuroscience molecule spotlight on Suvorexant.
Topics: Animals; Azepines; Clinical Trials, Phase I as Topic; Clinical Trials, Phase III as Topic; gamma-Aminobutyric Acid; Humans; Hypnotics and Sedatives; Intracellular Signaling Peptides and Proteins; Neuropeptides; Orexins; Sleep Initiation and Maintenance Disorders; Triazoles | 2012 |
Safety and tolerability of the new antidepressants.
Topics: Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Cyclohexanols; Depressive Disorder; Headache; Humans; Mianserin; Mirtazapine; Nausea; Piperazines; Selective Serotonin Reuptake Inhibitors; Sleep Initiation and Maintenance Disorders; Triazoles; Venlafaxine Hydrochloride | 1997 |
Antidepressant treatment of the depressed patient with insomnia.
Topics: Antidepressive Agents, Tricyclic; Comorbidity; Cyclohexanols; Depressive Disorder; Fluoxetine; Humans; Mianserin; Mirtazapine; Piperazines; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Sleep; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Triazoles; Venlafaxine Hydrochloride | 1999 |
41 trial(s) available for triazoles and Chronic Insomnia
| Article | Year |
|---|---|
A double-blind, randomized, placebo-controlled trial of suvorexant for the treatment of vasomotor symptom-associated insomnia disorder in midlife women.
Topics: Azepines; Double-Blind Method; Female; Humans; Orexin Receptor Antagonists; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Triazoles | 2022 |
Evaluation of suvorexant for trauma-related insomnia.
Topics: Azepines; Double-Blind Method; Humans; Orexin Receptor Antagonists; Sleep Initiation and Maintenance Disorders; Triazoles | 2022 |
Can the Orexin Antagonist Suvorexant Preserve the Ability to Awaken to Auditory Stimuli While Improving Sleep?
Topics: Acoustic Stimulation; Adult; Azepines; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Orexin Receptor Antagonists; Polysomnography; Sleep Initiation and Maintenance Disorders; Triazoles; Wakefulness; Young Adult | 2019 |
Polysomnographic assessment of suvorexant in patients with probable Alzheimer's disease dementia and insomnia: a randomized trial.
Topics: Aged; Alzheimer Disease; Azepines; Female; Humans; Male; Polysomnography; Sleep; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Triazoles | 2020 |
Daridorexant, a New Dual Orexin Receptor Antagonist to Treat Insomnia Disorder.
Topics: Adult; Benzimidazoles; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Imidazoles; Middle Aged; Orexin Receptor Antagonists; Pyrrolidines; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Triazoles; Zolpidem | 2020 |
Sleep and pain in humans with fibromyalgia and comorbid insomnia: double-blind, crossover study of suvorexant 20 mg versus placebo.
Topics: Adult; Aged; Azepines; Cross-Over Studies; Double-Blind Method; Female; Fibromyalgia; Humans; Middle Aged; Pain; Sleep; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Triazoles; Young Adult | 2020 |
Daridorexant, a new dual orexin receptor antagonist, in elderly subjects with insomnia disorder.
Topics: Aged; Aged, 80 and over; Benzimidazoles; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Imidazoles; Male; Orexin Receptor Antagonists; Polysomnography; Pyrrolidines; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Triazoles | 2020 |
Effect of Suvorexant vs Placebo on Total Daytime Sleep Hours in Shift Workers: A Randomized Clinical Trial.
Topics: Actigraphy; Adult; Azepines; California; Case-Control Studies; Circadian Rhythm; Double-Blind Method; Female; Humans; Male; Middle Aged; Orexin Receptor Antagonists; Placebos; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Initiation and Maintenance Disorders; Triazoles | 2020 |
Lemborexant for the Treatment of Insomnia: Direct and Indirect Comparisons With Other Hypnotics Using Number Needed to Treat, Number Needed to Harm, and Likelihood to Be Helped or Harmed.
Topics: Acetamides; Adolescent; Adult; Azepines; Benzodiazepines; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Orexin Receptor Antagonists; Pyridines; Pyrimidines; Sleep; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Triazoles; Young Adult; Zolpidem | 2021 |
Pilot evaluation of a consumer wearable device to assess sleep in a clinical polysomnography trial of suvorexant for treating insomnia in patients with Alzheimer's disease.
Topics: Alzheimer Disease; Azepines; Humans; Pilot Projects; Polysomnography; Sleep; Sleep Initiation and Maintenance Disorders; Triazoles; Wearable Electronic Devices | 2021 |
Suvorexant in Elderly Patients with Insomnia: Pooled Analyses of Data from Phase III Randomized Controlled Clinical Trials.
Topics: Aged; Azepines; Double-Blind Method; Female; Humans; Male; Meta-Analysis as Topic; Polysomnography; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Triazoles | 2017 |
Insight Into Reduction of Wakefulness by Suvorexant in Patients With Insomnia: Analysis of Wake Bouts.
Topics: Aged; Azepines; Data Collection; Double-Blind Method; Female; Healthy Volunteers; Humans; Male; Orexin Receptor Antagonists; Placebos; Polysomnography; Problem Solving; Self Report; Sleep; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Triazoles; Wakefulness; Zolpidem | 2018 |
Suvorexant for the treatment of insomnia in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Azepines; Female; Humans; Male; Orexin Receptor Antagonists; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Triazoles | 2018 |
A randomized Phase 2 study to evaluate the orexin-2 receptor antagonist seltorexant in individuals with insomnia without psychiatric comorbidity.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Female; Headache; Humans; Male; Middle Aged; Orexin Receptor Antagonists; Orexin Receptors; Polysomnography; Pyrimidines; Pyrroles; Sleep; Sleep Initiation and Maintenance Disorders; Sleepiness; Surveys and Questionnaires; Time Factors; Treatment Outcome; Triazoles; Young Adult | 2018 |
Addition of Suvorexant to Ramelteon Therapy for Improved Sleep Quality with Reduced Delirium Risk in Acute Stroke Patients.
Topics: Aged; Aged, 80 and over; Azepines; Delirium; Drug Therapy, Combination; Female; GABA Agonists; Humans; Indenes; Male; Orexin Receptor Antagonists; Receptors, Melatonin; Retrospective Studies; Risk Factors; Sleep; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Stroke; Treatment Outcome; Triazoles | 2019 |
Effects of suvorexant on the Insomnia Severity Index in patients with insomnia: analysis of pooled phase 3 data.
Topics: Adolescent; Adult; Aged; Azepines; Double-Blind Method; Female; Humans; Male; Middle Aged; Orexin Receptor Antagonists; Outcome Assessment, Health Care; Severity of Illness Index; Sleep Initiation and Maintenance Disorders; Triazoles; Young Adult | 2019 |
The selective orexin-2 receptor antagonist seltorexant improves sleep: An exploratory double-blind, placebo controlled, crossover study in antidepressant-treated major depressive disorder patients with persistent insomnia.
Topics: Adult; Aged; Antidepressive Agents; Cross-Over Studies; Depressive Disorder, Major; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Orexin Receptor Antagonists; Polysomnography; Pyrimidines; Pyrroles; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Triazoles; Young Adult | 2019 |
Effects of suvorexant on sleep apnea in patients with heart failure: A protocol of crossover pilot trial.
Topics: Azepines; Cross-Over Studies; Equivalence Trials as Topic; Female; Heart Failure; Humans; Male; Middle Aged; Pilot Projects; Polysomnography; Randomized Controlled Trials as Topic; Sleep; Sleep Aids, Pharmaceutical; Sleep Apnea Syndromes; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Triazoles | 2019 |
Effect of suvorexant on nighttime blood pressure in hypertensive patients with insomnia: The SUPER-1 study.
Topics: Antihypertensive Agents; Azepines; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Double-Blind Method; Drug Administration Schedule; Drug Monitoring; Female; Humans; Hypertension; Male; Middle Aged; Orexin Receptor Antagonists; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Triazoles | 2019 |
Suvorexant for insomnia in patients with psychiatric disorder: A 1-week, open-label study.
Topics: Adult; Aged; Azepines; Female; Humans; Male; Mental Disorders; Middle Aged; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Triazoles | 2019 |
Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial.
Topics: Adult; Age Factors; Aged; Azepines; Double-Blind Method; Female; Follow-Up Studies; Humans; Hypnotics and Sedatives; Male; Middle Aged; Orexin Receptor Antagonists; Retrospective Studies; Sleep Initiation and Maintenance Disorders; Time Factors; Treatment Outcome; Triazoles | 2014 |
Electroencephalographic power spectral density profile of the orexin receptor antagonist suvorexant in patients with primary insomnia and healthy subjects.
Topics: Adult; Aged; Azepines; Cross-Over Studies; Double-Blind Method; Electroencephalography; Female; Healthy Volunteers; Humans; Isoxazoles; Male; Middle Aged; Orexin Receptor Antagonists; Polysomnography; Pyridines; Sleep; Sleep Initiation and Maintenance Disorders; Triazoles; Young Adult; Zolpidem | 2014 |
Suvorexant: a novel therapy for the treatment of insomnia.
Topics: Adult; Aged; Aged, 80 and over; Azepines; Female; Humans; Male; Middle Aged; Orexin Receptor Antagonists; Sleep Initiation and Maintenance Disorders; Triazoles | 2014 |
Suvorexant in Patients With Insomnia: Results From Two 3-Month Randomized Controlled Clinical Trials.
Topics: Aged; Azepines; Double-Blind Method; Female; Humans; Male; Middle Aged; Orexin Receptor Antagonists; Polysomnography; Sleep; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Triazoles; Wakefulness | 2016 |
Effects of Suvorexant, an Orexin Receptor Antagonist, on Respiration during Sleep In Patients with Obstructive Sleep Apnea.
Topics: Adolescent; Adult; Aged; Azepines; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Middle Aged; Orexin Receptor Antagonists; Polysomnography; Respiration; Sleep; Sleep Apnea, Obstructive; Sleep Initiation and Maintenance Disorders; Triazoles; Young Adult | 2016 |
Effects of suvorexant on sleep architecture and power spectral profile in patients with insomnia: analysis of pooled phase 3 data.
Topics: Azepines; Electroencephalography; Female; Humans; Male; Middle Aged; Orexin Receptor Antagonists; Polysomnography; Randomized Controlled Trials as Topic; Sleep Initiation and Maintenance Disorders; Sleep Stages; Triazoles | 2016 |
Suvorexant in Patients with Insomnia: Pooled Analyses of Three-Month Data from Phase-3 Randomized Controlled Clinical Trials.
Topics: Adolescent; Adult; Aged; Azepines; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Triazoles; Young Adult | 2016 |
On-the-road driving performance the morning after bedtime use of suvorexant 15 and 30 mg in healthy elderly.
Topics: Aged; Aged, 80 and over; Automobile Driving; Azabicyclo Compounds; Azepines; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Healthy Volunteers; Humans; Hypnotics and Sedatives; Male; Piperazines; Psychomotor Performance; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Time Factors; Triazoles | 2016 |
Clinical profile of suvorexant for the treatment of insomnia over 3 months in women and men: subgroup analysis of pooled phase-3 data.
Topics: Adult; Aged; Azepines; Disorders of Excessive Somnolence; Double-Blind Method; Female; Humans; Male; Middle Aged; Polysomnography; Sleep; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Statistics as Topic; Time Factors; Treatment Outcome; Triazoles | 2017 |
Orexin receptor antagonism for treatment of insomnia: a randomized clinical trial of suvorexant.
Topics: Adolescent; Adult; Azepines; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Orexin Receptors; Polysomnography; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Sleep; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Triazoles | 2012 |
Nefazodone in primary insomnia: an open pilot study.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Female; Humans; Male; Middle Aged; Patient Dropouts; Pilot Projects; Piperazines; Polysomnography; Psychiatric Status Rating Scales; Sleep Initiation and Maintenance Disorders; Triazoles | 2004 |
Pharmacokinetic interaction between voriconazole and methadone at steady state in patients on methadone therapy.
Topics: Adult; Antifungal Agents; Area Under Curve; Back Pain; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Interactions; Headache; Humans; Male; Metabolic Clearance Rate; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Pyrimidines; Sleep Initiation and Maintenance Disorders; Time Factors; Treatment Outcome; Triazoles; Voriconazole | 2007 |
Effect of a new thienodiazepine (We-941) on sleep patterns of normal and insomniac subjects.
Topics: Adolescent; Adult; Azepines; Clinical Trials as Topic; Flurazepam; Humans; Hypnotics and Sedatives; Male; Placebos; Sleep; Sleep Initiation and Maintenance Disorders; Triazoles | 1981 |
Nefazodone in major depression: adjunctive benzodiazepine therapy and tolerability.
Topics: Adult; Aged; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Benzodiazepines; Depressive Disorder; Drug Therapy, Combination; Female; Half-Life; Humans; Male; Middle Aged; Piperazines; Prospective Studies; Psychiatric Status Rating Scales; Sleep; Sleep Initiation and Maintenance Disorders; Triazoles | 1998 |
Comparative effects of nefazodone and fluoxetine on sleep in outpatients with major depressive disorder.
Topics: Adult; Ambulatory Care; Antidepressive Agents, Second-Generation; Circadian Rhythm; Comorbidity; Depressive Disorder; Double-Blind Method; Electroencephalography; Female; Fluoxetine; Humans; Male; Middle Aged; Piperazines; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Sleep; Sleep Initiation and Maintenance Disorders; Sleep, REM; Triazoles; Wakefulness | 1998 |
Open trial of nefazodone for combat-related posttraumatic stress disorder.
Topics: Adult; Ambulatory Care; Anger; Antidepressive Agents, Second-Generation; Combat Disorders; Depressive Disorder; Drug Administration Schedule; Follow-Up Studies; Humans; Male; Middle Aged; Personality Inventory; Piperazines; Psychiatric Status Rating Scales; Sleep; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Triazoles | 1998 |
Evaluation of sleep architecture and cyclic alternating pattern rates in depressed insomniac patients treated with nefazodone hydrochloride.
Topics: Adult; Antidepressive Agents, Second-Generation; Depression; Female; Humans; Male; Periodicity; Piperazines; Placebos; Polysomnography; Single-Blind Method; Sleep; Sleep Initiation and Maintenance Disorders; Sleep, REM; Substance Withdrawal Syndrome; Triazoles | 1999 |
Differential effects of nefazodone and cognitive behavioral analysis system of psychotherapy on insomnia associated with chronic forms of major depression.
Topics: Adult; Antidepressive Agents, Second-Generation; Chronic Disease; Cognitive Behavioral Therapy; Combined Modality Therapy; Depressive Disorder; Drug Administration Schedule; Female; Humans; Linear Models; Male; Outcome Assessment, Health Care; Personality Inventory; Piperazines; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Triazoles | 2002 |
The effect of triazolam on the sleep of insomniacs.
Topics: Adult; Benzazepines; Clinical Trials as Topic; Electroencephalography; Electromyography; Electrooculography; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Placebos; Sleep; Sleep Initiation and Maintenance Disorders; Sleep Stages; Sleep, REM; Triazoles | 1975 |
Comparison of the hypnotic activity of triazolam, flurazepam hydrochloride, and placebo.
Topics: Adult; Aged; Anti-Anxiety Agents; Benzazepines; Chlorobenzenes; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Flurazepam; Humans; Hypnotics and Sedatives; Male; Middle Aged; Placebos; Sleep Initiation and Maintenance Disorders; Triazoles | 1975 |
Triazolam in insomniac family practice patients.
Topics: Benzodiazepines; Clinical Trials as Topic; Emotions; Family Practice; Female; Humans; Hypnotics and Sedatives; Male; Personality Inventory; Placebos; Secobarbital; Sleep Initiation and Maintenance Disorders; Surveys and Questionnaires; Triazoles | 1975 |
53 other study(ies) available for triazoles and Chronic Insomnia
| Article | Year |
|---|---|
Changes in Healthcare Resource Use and Costs in Commercially Insured Insomnia Patients Initiating Suvorexant.
Topics: Aged; Azepines; Delivery of Health Care; Female; Health Care Costs; Humans; Male; Medicare; Middle Aged; Retrospective Studies; Sleep Initiation and Maintenance Disorders; Triazoles; United States | 2021 |
Suvorexant for Primary Insomnia in a Patient at High Risk for Hypnotic Dependence.
Topics: Azepines; Humans; Hypnotics and Sedatives; Sleep Initiation and Maintenance Disorders; Triazoles | 2022 |
Effectiveness of change from suvorexant to lemborexant drug in the treatment of sleep disorders.
Topics: Azepines; Humans; Pyridines; Pyrimidines; Sleep; Sleep Initiation and Maintenance Disorders; Triazoles | 2022 |
Suvorexant for Preventing Alzheimer's Disease.
Topics: Alzheimer Disease; Azepines; Humans; Sleep Initiation and Maintenance Disorders; Triazoles | 2023 |
Safety profile and clinical course of patients with insomnia administered suvorexant by initial treatment status in a post-marketing survey.
Topics: Aged; Azepines; Female; Humans; Male; Middle Aged; Orexin Receptor Antagonists; Product Surveillance, Postmarketing; Prospective Studies; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Surveys and Questionnaires; Treatment Outcome; Triazoles | 2019 |
The dual orexinergic receptor antagonist DORA-22 improves the sleep disruption and memory impairment produced by a rodent insomnia model.
Topics: Animals; Pharmaceutical Preparations; Piperidines; Rats; Rodentia; Sleep; Sleep Initiation and Maintenance Disorders; Triazoles | 2020 |
Real-world evidence of the safety and efficacy profile of suvorexant in elderly patients with insomnia: a sub-analysis of the post-marketing drug-use results survey in Japan.
Topics: Aged; Azepines; Dizziness; Female; Humans; Japan; Male; Middle Aged; Product Surveillance, Postmarketing; Sleep Initiation and Maintenance Disorders; Surveys and Questionnaires; Triazoles | 2020 |
How well can a large number of polysomnography sleep measures predict subjective sleep quality in insomnia patients?
Topics: Age Factors; Analgesics; Azepines; Female; Humans; Isoxazoles; Male; Middle Aged; Polysomnography; Predictive Value of Tests; Sleep Aids, Pharmaceutical; Sleep Hygiene; Sleep Initiation and Maintenance Disorders; Time Factors; Triazoles | 2020 |
Daridorexant: A new medication for insomnia in older adults?
Topics: Aged; Benzimidazoles; Female; Humans; Imidazoles; Male; Patient Education as Topic; Pyrrolidines; Sleep Initiation and Maintenance Disorders; Triazoles | 2020 |
Real-World Preventive Effects of Suvorexant in Intensive Care Delirium: A Retrospective Cohort Study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azepines; Child; Child, Preschool; Critical Care; Delirium; Female; Humans; Male; Middle Aged; Orexin Receptor Antagonists; Outcome Assessment, Health Care; Prevalence; Proportional Hazards Models; Retrospective Studies; Selective Serotonin Reuptake Inhibitors; Sleep Initiation and Maintenance Disorders; Trazodone; Triazoles; Young Adult | 2020 |
Quetiapine may complete the best match with suvorexant in psychiatric patients with insomnia.
Topics: Azepines; Humans; Quetiapine Fumarate; Sleep Initiation and Maintenance Disorders; Triazoles | 2021 |
Prompt improvement of difficulty with sleep initiation and waking up in the morning and daytime somnolence by combination therapy of suvorexant and ramelteon in delayed sleep-wake phase disorder: a case series of three patients.
Topics: Adult; Azepines; Disorders of Excessive Somnolence; Female; Humans; Indenes; Male; Sleep; Sleep Initiation and Maintenance Disorders; Triazoles; Young Adult | 2021 |
Significant decrease in delirium referrals after changing hypnotic from benzodiazepine to suvorexant.
Topics: Aged; Azepines; Benzodiazepines; Delirium; Humans; Hypnotics and Sedatives; Referral and Consultation; Sleep Initiation and Maintenance Disorders; Triazoles | 2021 |
Suvorexant improves intractable nocturnal enuresis by altering sleep architecture.
Topics: Azepines; Child; Cross-Over Studies; Double-Blind Method; Humans; Male; Nocturnal Enuresis; Sleep; Sleep Initiation and Maintenance Disorders; Triazoles | 2021 |
[Standardization of Hypnotic Agents for Prevention of Falls: A Pharmacoeconomic Study].
Topics: Accidental Falls; Aged; Aged, 80 and over; Azepines; Benzodiazepines; Cost-Benefit Analysis; Economics, Pharmaceutical; Eszopiclone; Female; Hospitalization; Humans; Hypnotics and Sedatives; Male; Middle Aged; Sleep Initiation and Maintenance Disorders; Triazoles | 2021 |
The dual orexin receptor antagonist, DORA-22, lowers histamine levels in the lateral hypothalamus and prefrontal cortex without lowering hippocampal acetylcholine.
Topics: Acetylcholine; Animals; gamma-Aminobutyric Acid; Hippocampus; Histamine; Hypothalamic Area, Lateral; Male; Orexin Receptor Antagonists; Piperidines; Prefrontal Cortex; Rats; Sleep; Sleep Initiation and Maintenance Disorders; Triazoles; Wakefulness | 2017 |
Suvorexant for the Treatment of Insomnia in Adolescents.
Topics: Adolescent; Azepines; Dreams; Female; Humans; Male; Orexin Receptor Antagonists; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Triazoles | 2017 |
Reduced insomnia following short-term administration of suvorexant during aripiprazole once-monthly treatment in a patient with schizophrenia.
Topics: Adult; Antipsychotic Agents; Aripiprazole; Azepines; Female; Humans; Schizophrenia; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Triazoles | 2017 |
Theacrine: A purine alkaloid from Camellia assamica var. kucha with a hypnotic property via the adenosine system.
Topics: Adenosine; Alkaloids; Animals; Caffeine; Camellia; Drug Synergism; Hippocampus; Male; Mice; Pentobarbital; Pyrimidines; Rats; Sleep Initiation and Maintenance Disorders; Sleep Stages; Triazoles; Uric Acid; Xanthines | 2017 |
Benefits of switching to suvorexant for mild primary insomnia when sleepwalking episodes occur during zolpidem treatment.
Topics: Adult; Azepines; Female; GABA-A Receptor Agonists; Humans; Orexin Receptor Antagonists; Sleep Initiation and Maintenance Disorders; Somnambulism; Treatment Outcome; Triazoles; Zolpidem | 2017 |
Suvorexant as an orexin antagonist may regulate serum glucose levels in psychiatric patients with insomnia.
Topics: Adult; Azepines; Blood Glucose; Comorbidity; Humans; Mental Disorders; Orexin Receptor Antagonists; Sleep Initiation and Maintenance Disorders; Triazoles | 2017 |
Benefits associated with switching from benzodiazepine hypnotics to suvorexant in patients with mild primary insomnia.
Topics: Adult; Azepines; Benzodiazepines; Female; Humans; Hypnotics and Sedatives; Muscle Hypotonia; Orexin Receptor Antagonists; Sleep Initiation and Maintenance Disorders; Substance Withdrawal Syndrome; Treatment Outcome; Triazoles | 2017 |
Adverse reaction with suvorexant for insomnia: acute worsening of depression with emergence of suicidal thoughts.
Topics: Antidepressive Agents; Azepines; Depressive Disorder, Major; Diagnosis, Differential; Female; Humans; Hypnotics and Sedatives; Middle Aged; Orexin Receptor Antagonists; Sleep Initiation and Maintenance Disorders; Suicidal Ideation; Treatment Outcome; Triazoles | 2017 |
Cost-effectiveness analysis of suvorexant for the treatment of Japanese elderly patients with chronic insomnia in a virtual cohort.
Topics: Aged; Aged, 80 and over; Azepines; Chronic Disease; Computer Simulation; Cost-Benefit Analysis; Female; Hip Fractures; Humans; Hypnotics and Sedatives; Japan; Male; Models, Econometric; Pyridines; Quality-Adjusted Life Years; Sleep Initiation and Maintenance Disorders; Triazoles; Zolpidem | 2018 |
Suvorexant-Induced Delirium.
Topics: Aged, 80 and over; Azepines; Delirium; Humans; Male; Orexin Receptor Antagonists; Sleep Initiation and Maintenance Disorders; Triazoles | 2018 |
Nail pitting and splinter hemorrhage possibly induced by zolpidem.
Topics: Adult; Drug Substitution; Female; Hemorrhage; Humans; Nail Diseases; Nails; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Triazoles; Young Adult; Zolpidem | 2019 |
Suvorexant (Belsomra
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azepines; Drug Utilization Review; Female; Humans; Japan; Male; Middle Aged; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Sleep Latency; Surveys and Questionnaires; Tablets; Triazoles; Young Adult | 2019 |
Effect of suvorexant on event-related oscillations and EEG sleep in rats exposed to chronic intermittent ethanol vapor and protracted withdrawal.
Topics: Alcoholism; Animals; Azepines; Electroencephalography; Ethanol; Humans; Male; Orexin Receptor Antagonists; Rats; Rats, Wistar; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Sleep Wake Disorders; Sleep, REM; Sleep, Slow-Wave; Substance Withdrawal Syndrome; Time Factors; Triazoles | 2019 |
Insomnia and hypertension: A misty landscape.
Topics: Azepines; Blood Pressure; Humans; Hypertension; Sleep Initiation and Maintenance Disorders; Triazoles | 2019 |
Single-use suvorexant for treating insomnia during overnight polysomnography in patients with suspected obstructive sleep apnea: a single-center experience.
Topics: Azepines; Humans; Polysomnography; Sleep Aids, Pharmaceutical; Sleep Apnea, Obstructive; Sleep Initiation and Maintenance Disorders; Triazoles | 2019 |
Use of Suvorexant for Sleep Regulation in an Adolescent with Early-Onset Bipolar Disorder.
Topics: Adolescent; Anticonvulsants; Antipsychotic Agents; Azepines; Bipolar Disorder; Humans; Lurasidone Hydrochloride; Male; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Triazoles; Valproic Acid | 2019 |
Insomnia: chasing the dream.
Topics: Animals; Arousal; Azabicyclo Compounds; Azepines; Benzodiazepines; Cognitive Behavioral Therapy; Doxepin; Dreams; Histamine Agonists; Histamine Antagonists; Humans; Hypnotics and Sedatives; Hypothalamus; Orexin Receptors; Piperazines; Piperidines; Receptors, G-Protein-Coupled; Receptors, GABA; Receptors, Histamine H3; Receptors, Neuropeptide; Sleep Initiation and Maintenance Disorders; Triazoles | 2013 |
First-in-class insomnia drug on the brink of approval nod.
Topics: Azepines; Clinical Trials as Topic; Drug Approval; Humans; Orexin Receptors; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Sleep Initiation and Maintenance Disorders; Triazoles; United States; United States Food and Drug Administration | 2013 |
Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia.
Topics: Animals; Azepines; Electroencephalography; Electromyography; Indoles; Male; Mice; Mice, Inbred C57BL; Motor Activity; Orexin Receptor Antagonists; Pyrimidines; Quinoxalines; Sleep; Sleep Initiation and Maintenance Disorders; Sleep Stages; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship; Triazoles | 2013 |
Orexin receptor antagonists: a new treatment for insomnia?
Topics: Azepines; Female; Humans; Hypnotics and Sedatives; Male; Orexin Receptor Antagonists; Sleep Initiation and Maintenance Disorders; Triazoles | 2014 |
Suvorexant approved for insomnia.
Topics: Azepines; Humans; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Triazoles | 2014 |
Insomniacs get new mechanism sleep drug Belsomra.
Topics: Azepines; Clinical Trials as Topic; Drug Approval; Drug Industry; Humans; Sleep Initiation and Maintenance Disorders; Triazoles | 2014 |
Suvorexant: something new for sleep?
Topics: Animals; Azepines; Drug Interactions; Humans; Hypnotics and Sedatives; Orexin Receptor Antagonists; Sleep Initiation and Maintenance Disorders; Triazoles | 2015 |
Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant.
Topics: Azepines; Crystallography, X-Ray; Humans; Molecular Docking Simulation; Orexin Receptor Antagonists; Orexin Receptors; Protein Conformation; Receptors, G-Protein-Coupled; Recombinant Fusion Proteins; Sleep Initiation and Maintenance Disorders; Triazoles | 2015 |
Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties.
Topics: Animals; Dogs; Half-Life; Mice; Orexin Receptor Antagonists; Orexin Receptors; Piperidines; Protein Binding; Pyrimidines; Rats; Sleep Initiation and Maintenance Disorders; Structure-Activity Relationship; Triazoles | 2015 |
In vitro and in vivo characterisation of the metabolism and disposition of suvorexant in humans.
Topics: Adult; Azepines; Female; Healthy Volunteers; Humans; Male; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Triazoles | 2016 |
Suvorexant (Belsomra) for Insomnia.
Topics: Azepines; Education, Medical, Continuing; Humans; Practice Guidelines as Topic; Practice Patterns, Physicians'; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Triazoles | 2016 |
Mechanism of action of suvorexant.
Topics: Arousal; Azepines; Humans; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Triazoles; Wakefulness | 2016 |
Suvorexant-Induced Dream Enactment Behavior in Parkinson Disease: A Case Report.
Topics: Aged; Azepines; Dreams; Humans; Male; Parasomnias; Parkinson Disease; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Triazoles | 2017 |
Preclinical assessment of the abuse potential of the orexin receptor antagonist, suvorexant.
Topics: Animals; Azepines; Humans; Hypnotics and Sedatives; Macaca mulatta; Orexin Receptor Antagonists; Rats; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Substance-Related Disorders; Triazoles | 2017 |
Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia.
Topics: Animals; Azepines; Biological Availability; CHO Cells; Cricetinae; Cricetulus; Dogs; Humans; In Vitro Techniques; Male; Microsomes, Liver; Orexin Receptors; Radioligand Assay; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Sleep; Sleep Initiation and Maintenance Disorders; Stereoisomerism; Structure-Activity Relationship; Telemetry; Triazoles; Wakefulness | 2010 |
Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties.
Topics: Animals; Brain; Dogs; Drug Discovery; Humans; Hypnotics and Sedatives; Magnetic Resonance Spectroscopy; Models, Molecular; Orexin Receptors; Piperidines; Protein Binding; Pyridines; Rats; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Sleep; Sleep Initiation and Maintenance Disorders; Stereoisomerism; Structure-Activity Relationship; Triazoles; Wakefulness | 2012 |
New class of sleep drugs may offer a safer night's rest.
Topics: Azepines; Clinical Trials as Topic; Humans; Intracellular Signaling Peptides and Proteins; Neuropeptides; Orexins; Patient Safety; Sleep; Sleep Initiation and Maintenance Disorders; Triazoles; United States; United States Food and Drug Administration | 2012 |
Neurological adverse events to voriconazole: evidence for therapeutic drug monitoring.
Topics: Adult; Antifungal Agents; Asthenia; Cognition Disorders; Dose-Response Relationship, Drug; Drug Monitoring; Female; Hallucinations; Humans; Irritable Mood; Male; Middle Aged; Peripheral Nervous System Diseases; Pyrimidines; Retrospective Studies; Sleep Initiation and Maintenance Disorders; Triazoles; Vision Disorders; Voriconazole | 2006 |
[Nefazodone: a new antidepressive agent. Advantages of a dual working principle].
Topics: Antidepressive Agents, Second-Generation; Depressive Disorder; Humans; Piperazines; Sleep; Sleep Initiation and Maintenance Disorders; Triazoles | 1997 |
[Sleep-profile of a 72-year-old depressive female patient. Depression and sleep disorders. Significance--causes--treatment].
Topics: Aged; Antidepressive Agents, Second-Generation; Depression; Female; Humans; Piperazines; Sleep Initiation and Maintenance Disorders; Sleep, REM; Triazoles | 1998 |
[Depression and sleep disorders. Progress in antidepressive therapy with nefazodone].
Topics: Antidepressive Agents, Second-Generation; Depression; Humans; Piperazines; Sleep Initiation and Maintenance Disorders; Triazoles | 1998 |
Anxiolytic effects of a new triazolobenzodiazepine, U-31,889.
Topics: Adult; Animals; Anxiety; Behavior, Animal; Benzodiazepinones; Blood Circulation; Central Nervous System; Computers; Depression; Dogs; Electroencephalography; Female; Flurazepam; Humans; Hypnotics and Sedatives; Leukocyte Count; Male; Middle Aged; Movement Disorders; Respiration; Seizures; Sleep; Sleep Initiation and Maintenance Disorders; Tranquilizing Agents; Triazoles | 1973 |