Compounds > triazoles
Page last updated: 2024-08-24

triazoles and r 115866

triazoles has been researched along with r 115866 in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's13 (50.00)29.6817
2010's11 (42.31)24.3611
2020's2 (7.69)2.80

Authors

AuthorsStudies
Borgers, M; Borghgraef, P; Dillen, L; Goossens, J; Nobels, G; Sanz, G; Stoppie, P; Szel, H; Van Hove, C; Van Nyen, G; Van Wauwe, J; Vanden Bossche, H; Venet, M; Willemsens, G1
Barrett, C; Guidato, S; Guthrie, S1
Baldini, A; Cook, AC; Ivins, S; Roberts, C; Scambler, PJ1
Barbera, MC; Brancale, A; Gomaa, MS; Milbourne, CE; Simons, C; Yee, SW1
Bovenschen, HJ; Langewouters, AM; Otero, ME; Seyger, MM; van de Kerkhof, PC; van Rens, DW; van Vlijmen-Willems, IM1
Boersma, IH; Borgers, M; Coel, M; Mertens, J; Roseeuw, D; Verfaille, CJ1
Gidlöf, AC; Ocaya, P; Olofsson, PS; Sirsjö, A; Törmä, H1
Bovenschen, HJ; Mertens, J; Steijlen, PM; Thissen, CA; van de Kerkhof, PC; Verfaille, CJ1
Geria, AN; Scheinfeld, NS1
Borgers, M; Cools, M; Hagforsen, E; Pavez Loriè, E; Shroot, B; Törmä, H; Vahlquist, A; Wouters, L1
Frankart, A; Giltaire, S; Hérin, M; Herphelin, F; Poumay, Y; Stoppie, P1
Li, H; Pavez Loriè, E; Törmä, H; Vahlquist, A1
Chamcheu, JC; Pavez Loriè, E; Törmä, H; Vahlquist, A1
Fritzsche, B; Nau, H; Rühl, R; Schmidt, A; Schuchardt, JP; Schweigert, FJ1
Elmabsout, AA; Gidlöf, AC; Ocaya, PA; Olofsson, PS; Sirsjö, A; Törmä, H1
Baert, B; De Spiegeleer, B1
Barragan, M; Eguizabal, C; Garcia-Quevedo, L; Garreta, E; Giorgetti, A; Izpisua Belmonte, JC; Montserrat, N; Vassena, R; Veiga, A; Vidal, F1
Awadalla, MK; Elmabsout, AA; Eriksson, LA; Saenz-Méndez, P; Sävenstrand, H; Sirsjö, A; Strid, Å1
Chimal-Monroy, J; Cuervo, R1
Andersson, G; Hu, L; Jacobson, A; Lind, T; Melhus, H; Pejler, G; Sundqvist, A1
Kasimanickam, R; Kasimanickam, V1
Dernell, WS; Kasimanickam, RK; Kasimanickam, VR1
Hammerschmidt, M; Jeradi, S1
Arnold, SL; Chapman, JD; Goodlett, DR; Han, CY; Hogarth, CA; Isoherranen, N; Kent, T; Onken, J; Tripathy, S1
Balau, B; Bourlond, F; De Glas, V; Diaz, P; Liu, H; Paller, AS; Poumay, Y; Veit, JGS1
Foster, DB; Jones, JW; Kane, MA; Liu, T; Margulies, KB; O'Rourke, B; Papanicolaou, KN; Parker, LE; Talbot, CC; Yang, N; Yu, J1

Reviews

2 review(s) available for triazoles and r 115866

ArticleYear
Talarozole, a selective inhibitor of P450-mediated all-trans retinoic acid for the treatment of psoriasis and acne.
    Current opinion in investigational drugs (London, England : 2000), 2008, Volume: 9, Issue:11

    Topics: Acne Vulgaris; Animals; Benzothiazoles; Clinical Trials as Topic; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Humans; Psoriasis; Structure-Activity Relationship; Tretinoin; Triazoles

2008
Characterization of CYP26B1-Selective Inhibitor, DX314, as a Potential Therapeutic for Keratinization Disorders.
    The Journal of investigative dermatology, 2021, Volume: 141, Issue:1

    Topics: Benzothiazoles; Cell Differentiation; Cytochrome P-450 Enzyme Inhibitors; Epidermis; Humans; Keratinocytes; Retinoic Acid 4-Hydroxylase; Skin Diseases; Triazoles

2021

Trials

3 trial(s) available for triazoles and r 115866

ArticleYear
Oral retinoic acid metabolism blocking agent Rambazole for plaque psoriasis: an immunohistochemical study.
    The British journal of dermatology, 2007, Volume: 156, Issue:2

    Topics: Administration, Oral; Adult; Benzothiazoles; Cell Proliferation; Dermatologic Agents; Female; Humans; Immunohistochemistry; Keratolytic Agents; Male; Middle Aged; Psoriasis; Tretinoin; Triazoles

2007
Oral R115866 in the treatment of moderate to severe plaque-type psoriasis.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2007, Volume: 21, Issue:8

    Topics: Administration, Oral; Adult; Aged; Benzothiazoles; Dermatologic Agents; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Psoriasis; Severity of Illness Index; Statistics, Nonparametric; Treatment Outcome; Triazoles

2007
Topical treatment with CYP26 inhibitor talarozole (R115866) dose dependently alters the expression of retinoid-regulated genes in normal human epidermis.
    The British journal of dermatology, 2009, Volume: 160, Issue:1

    Topics: Administration, Topical; Adolescent; Adult; Analysis of Variance; Benzothiazoles; Biomarkers; Cell Proliferation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Double-Blind Method; Epidermis; Female; Gene Expression; Humans; Immunohistochemistry; Male; Middle Aged; Receptors, Retinoic Acid; Retinal Dehydrogenase; Retinoic Acid 4-Hydroxylase; Retinoids; RNA, Messenger; Triazoles; Young Adult

2009

Other Studies

21 other study(ies) available for triazoles and r 115866

ArticleYear
R115866 inhibits all-trans-retinoic acid metabolism and exerts retinoidal effects in rodents.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 293, Issue:1

    Topics: Animals; Aromatase Inhibitors; Benzothiazoles; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Epidermis; Female; Humans; Hyperplasia; Keratosis; Male; Mice; Ovariectomy; Rats; Rats, Wistar; Retinoids; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Tissue Distribution; Tretinoin; Triazoles; Vagina

2000
Patterning of motor neurons by retinoic acid in the chick embryo hindbrain in vitro.
    Molecular and cellular neurosciences, 2003, Volume: 23, Issue:1

    Topics: Animals; Antineoplastic Agents; Benzothiazoles; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Endoderm; Gene Expression Regulation, Developmental; Homeodomain Proteins; In Situ Hybridization; In Vitro Techniques; LIM-Homeodomain Proteins; Mesoderm; Motor Neurons; Nerve Tissue Proteins; Retinoic Acid 4-Hydroxylase; Rhombencephalon; Thiazoles; Transcription Factors; Tretinoin; Triazoles

2003
Cyp26 genes a1, b1 and c1 are down-regulated in Tbx1 null mice and inhibition of Cyp26 enzyme function produces a phenocopy of DiGeorge Syndrome in the chick.
    Human molecular genetics, 2006, Dec-01, Volume: 15, Issue:23

    Topics: Abnormalities, Multiple; Animals; Benzothiazoles; Chick Embryo; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DiGeorge Syndrome; Down-Regulation; Male; Mice; Mice, Knockout; Retinoic Acid 4-Hydroxylase; T-Box Domain Proteins; Tretinoin; Triazoles

2006
Homology model of human retinoic acid metabolising enzyme cytochrome P450 26A1 (CYP26A1): active site architecture and ligand binding.
    Journal of enzyme inhibition and medicinal chemistry, 2006, Volume: 21, Issue:4

    Topics: Alcohol Dehydrogenase; Algorithms; Amino Acid Sequence; Benzothiazoles; Binding Sites; Cytochrome P-450 Enzyme System; Humans; Ligands; Models, Molecular; Molecular Sequence Data; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Retinoic Acid 4-Hydroxylase; Sequence Homology, Amino Acid; Tretinoin; Triazoles

2006
Oral R115866 in the treatment of moderate to severe facial acne vulgaris: an exploratory study.
    The British journal of dermatology, 2007, Volume: 157, Issue:1

    Topics: Acne Vulgaris; Administration, Oral; Adolescent; Adult; Benzothiazoles; Dermatologic Agents; Dose-Response Relationship, Drug; Humans; Male; Middle Aged; Patient Compliance; Tretinoin; Triazoles

2007
CYP26 inhibitor R115866 increases retinoid signaling in intimal smooth muscle cells.
    Arteriosclerosis, thrombosis, and vascular biology, 2007, Volume: 27, Issue:7

    Topics: Analysis of Variance; Animals; Aorta, Thoracic; Benzothiazoles; Cell Proliferation; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disease Models, Animal; Male; Muscle, Smooth, Vascular; Probability; Protein Isoforms; Rats; Rats, Sprague-Dawley; Retinoids; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity; Signal Transduction; Triazoles; Tunica Intima; Tunica Media

2007
The CYP26 inhibitor R115866 potentiates the effects of all-trans retinoic acid on cultured human epidermal keratinocytes.
    The British journal of dermatology, 2009, Volume: 160, Issue:3

    Topics: Adult; Benzothiazoles; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Epidermal Cells; Epidermis; Gene Expression Regulation; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Keratin-10; Keratinocytes; Protein Precursors; Tretinoin; Triazoles

2009
The involvement of cytochrome p450 (CYP) 26 in the retinoic acid metabolism of human epidermal keratinocytes.
    Biochimica et biophysica acta, 2009, Volume: 1791, Issue:3

    Topics: Benzothiazoles; Calcium; Cell Differentiation; Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Epidermal Cells; Epidermis; Fluorescent Antibody Technique; Foreskin; Gene Expression Regulation, Enzymologic; Humans; Immunoblotting; Infant, Newborn; Keratinocytes; Male; Receptors, Retinoic Acid; Retinoic Acid 4-Hydroxylase; RNA, Messenger; RNA, Small Interfering; Tretinoin; Triazoles; Vitamin A

2009
Both all-trans retinoic acid and cytochrome P450 (CYP26) inhibitors affect the expression of vitamin A metabolizing enzymes and retinoid biomarkers in organotypic epidermis.
    Archives of dermatological research, 2009, Volume: 301, Issue:7

    Topics: Acyltransferases; Alcohol Oxidoreductases; Androgen Antagonists; Benzothiazoles; Biomarkers; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Epidermis; Feedback, Physiological; Gene Expression Regulation, Enzymologic; Heparin-binding EGF-like Growth Factor; Humans; Imidazoles; Intercellular Signaling Peptides and Proteins; Keratin-2; Keratin-4; Keratinocytes; Receptors, Retinoic Acid; Retinal Dehydrogenase; Retinoic Acid 4-Hydroxylase; Tretinoin; Triazoles; Vitamin A

2009
CYP26A1-specific antagonist influence on embryonic implantation, gene expression and endogenous retinoid concentration in rats.
    Reproductive toxicology (Elmsford, N.Y.), 2010, Volume: 30, Issue:3

    Topics: Animals; Benzothiazoles; Body Weight; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Embryo Implantation; Female; Gene Expression; Liver; Organ Size; Pregnancy; Rats; Rats, Wistar; Retinoic Acid 4-Hydroxylase; Retinoids; Reverse Transcriptase Polymerase Chain Reaction; Triazoles; Uterus

2010
CYP26B1 plays a major role in the regulation of all-trans-retinoic acid metabolism and signaling in human aortic smooth muscle cells.
    Journal of vascular research, 2011, Volume: 48, Issue:1

    Topics: Aorta; Benzothiazoles; Cell Division; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Enzymologic; Humans; Muscle, Smooth, Vascular; Retinoic Acid 4-Hydroxylase; RNA, Small Interfering; Signal Transduction; Tretinoin; Triazoles

2011
Local skin pharmacokinetics of talarozole, a new retinoic acid metabolism-blocking agent.
    Skin pharmacology and physiology, 2011, Volume: 24, Issue:3

    Topics: Administration, Cutaneous; Adult; Benzothiazoles; Cytochrome P-450 Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Middle Aged; Skin Absorption; Solvents; Tissue Distribution; Triazoles

2011
Complete meiosis from human induced pluripotent stem cells.
    Stem cells (Dayton, Ohio), 2011, Volume: 29, Issue:8

    Topics: 3-Hydroxysteroid Dehydrogenases; Adaptor Proteins, Signal Transducing; Antigens, CD; Benzothiazoles; Cell Culture Techniques; Cell Cycle Proteins; Cell Differentiation; Cell Line; Colforsin; DEAD-box RNA Helicases; DNA Methylation; DNA-Binding Proteins; Fibroblast Growth Factor 2; Gene Expression; Gene Expression Regulation; Histones; Humans; Induced Pluripotent Stem Cells; Intermediate Filament Proteins; Karyotyping; Leukemia Inhibitory Factor; Male; Meiosis; Nerve Tissue Proteins; Nestin; Nuclear Proteins; Ploidies; Promoter Regions, Genetic; Proteins; Spermatogonia; Stage-Specific Embryonic Antigens; Triazoles; Vimentin

2011
Homology models of human all-trans retinoic acid metabolizing enzymes CYP26B1 and CYP26B1 spliced variant.
    Journal of chemical information and modeling, 2012, Oct-22, Volume: 52, Issue:10

    Topics: Alternative Splicing; Bacterial Proteins; Benzothiazoles; Crystallography, X-Ray; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Isoenzymes; Molecular Docking Simulation; Retinoic Acid 4-Hydroxylase; Structural Homology, Protein; Synechocystis; Tetralones; Thermodynamics; Tretinoin; Triazoles

2012
Chemical activation of RARβ induces post-embryonically bilateral limb duplication during Xenopus limb regeneration.
    Scientific reports, 2013, Volume: 3

    Topics: Animals; Benzoates; Benzothiazoles; Biphenyl Compounds; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Extremities; Larva; Receptors, Retinoic Acid; Regeneration; Retinoic Acid 4-Hydroxylase; Retinoids; Triazoles; Xenopus laevis

2013
Vitamin a is a negative regulator of osteoblast mineralization.
    PloS one, 2013, Volume: 8, Issue:12

    Topics: Animals; Benzoates; Benzothiazoles; Calcification, Physiologic; Cell Line; Core Binding Factor Alpha 1 Subunit; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Femur; Humans; Male; Osteoblasts; Rats; Rats, Sprague-Dawley; Receptors, Retinoic Acid; Retinoic Acid 4-Hydroxylase; Signal Transduction; Sp7 Transcription Factor; Thiophenes; Transcription Factors; Triazoles; Vitamin A; Vitamins

2013
Exogenous retinoic acid and cytochrome P450 26B1 inhibitor modulate meiosis-associated genes expression in canine testis, an in vitro model.
    Reproduction in domestic animals = Zuchthygiene, 2014, Volume: 49, Issue:2

    Topics: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Animals; Benzothiazoles; Dogs; Gene Expression Regulation; Male; Meiosis; Real-Time Polymerase Chain Reaction; RNA, Messenger; Spermatogenesis; Tissue Culture Techniques; Tretinoin; Triazoles

2014
Dysregulated microRNA clusters in response to retinoic acid and CYP26B1 inhibitor induced testicular function in dogs.
    PloS one, 2014, Volume: 9, Issue:6

    Topics: Animals; Benzothiazoles; Cluster Analysis; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dogs; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Male; MicroRNAs; Multigene Family; Retinoic Acid 4-Hydroxylase; Testis; Transcriptome; Tretinoin; Triazoles

2014
Retinoic acid-induced premature osteoblast-to-preosteocyte transitioning has multiple effects on calvarial development.
    Development (Cambridge, England), 2016, Apr-01, Volume: 143, Issue:7

    Topics: Animals; Animals, Genetically Modified; Benzothiazoles; Cell Differentiation; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Developmental; Metronidazole; Osteoblasts; Osteoclasts; Osteocytes; Osteogenesis; Retinoic Acid 4-Hydroxylase; Skull; Tretinoin; Triazoles; Zebrafish; Zebrafish Proteins

2016
All-Trans-Retinoic Acid Enhances Mitochondrial Function in Models of Human Liver.
    Molecular pharmacology, 2016, Volume: 89, Issue:5

    Topics: Animals; Benzothiazoles; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Female; Gene Expression Regulation, Enzymologic; Hep G2 Cells; Hepatocytes; Humans; Male; Mice; Mitochondria, Liver; Mitochondrial Dynamics; Organelle Biogenesis; PPAR delta; Receptors, Retinoic Acid; Retinoic Acid 4-Hydroxylase; Retinoic Acid Receptor alpha; RNA Interference; Signal Transduction; Tretinoin; Triazoles; Up-Regulation

2016
Cardiac retinoic acid levels decline in heart failure.
    JCI insight, 2021, 04-22, Volume: 6, Issue:8

    Topics: Adult; Aged; Animals; Animals, Newborn; Benzothiazoles; Cardiomyopathy, Dilated; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P450 Family 26; Female; Gene Expression Regulation; Guinea Pigs; Heart Failure; Heart Ventricles; Humans; Male; Middle Aged; Myocardium; Myocytes, Cardiac; Rats; Tretinoin; Triazoles; Ventricular Remodeling; Vitamin A; Young Adult

2021