triazoles has been researched along with adenosine in 373 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (1.88) | 18.7374 |
| 1990's | 86 (23.06) | 18.2507 |
| 2000's | 189 (50.67) | 29.6817 |
| 2010's | 86 (23.06) | 24.3611 |
| 2020's | 5 (1.34) | 2.80 |
| Authors | Studies |
|---|---|
| O'Regan, MH; Perkins, LM; Phillis, JW; Simpson, RE | 1 |
| Cox, BF; Lappe, RW; Sheldon, JH | 1 |
| Adén, U; Fredholm, BB; Johansson, B; Lindström, K; Svenningsson, P | 1 |
| Abels, BC; Branch, RA; Callis, JT; Sabra, R | 1 |
| Barraco, RA; Phillis, JW | 1 |
| Holtzman, SG; Mumford, GK | 1 |
| Holtzman, SG | 1 |
| Czuczwar, SJ; Janusz, W; Kleinrok, Z; Szczepanik, B | 1 |
| Do, UH; Jarvis, MF; Sills, MA; Williams, M | 1 |
| Bourguignon, JJ; Griebel, G; Misslin, R; Remmy, D; Saffroy-Spittler, M; Vogel, E | 1 |
| Brown, GL; Douglas, FL; Kotake, AN; Mustafa, SJ; Sabouni, MH | 1 |
| Behnke, N; Müller, W; Neumann, J; Schmitz, W; Scholz, H; Stein, B | 1 |
| Charlier, A; Keyeux, A; Pouleur, H; Raigoso, J; Schröder, E; Van Mechelen, H | 1 |
| Gewirtz, H; Mills, I | 1 |
| Browne, RG; Howard, HR; Koe, BK; Lebel, LA; Sarges, R; Seymour, PA | 1 |
| Abels, BC; Branch, KR; Branch, RA; Callis, JT; Jackson, EK; Kuan, CJ; Sabra, R | 1 |
| Braunwalder, A; Cash, WD; Francis, J; Ghai, G; Psychoyos, S; Stone, GA; Williams, M | 1 |
| Atkins, C; Cash, WD; Francis, JE; Friedmann, RC; Furness, P; Ghai, G; Hyun, JL; Psychoyos, S; Warren, V; Wenk, P | 1 |
| Cote, DT; Dotson, RA; Francis, JE; Ghai, G; Goodman, FR; Hopkins, MF; Williams, M; Zimmerman, MB | 1 |
| Hashimoto, K; Oguro, K; Taira, N | 1 |
| Huang, GF; Kawazoe, Y; Maeda, M; Okamoto, T | 1 |
| Reese, CB; Ubasawa, A | 1 |
| Amoroso, S; Annunziato, L; Di Renzo, G; Iannotti, E; Saggese, ML | 1 |
| Howell, LL; Landrum, AM | 1 |
| Imaizumi, M; Miyazaki, S; Onodera, K | 1 |
| Cazin, L; Mei, YA; Vaudry, H | 1 |
| Jarvis, JE; Reeves, JJ; Sheehan, MJ; Strong, P | 1 |
| Becker, BF; Raschke, P | 1 |
| Borchard, U; Felsch, A; Stöcker, K | 1 |
| Patel, M; Sheehan, MJ; Strong, P | 1 |
| Schmitz, W; Scholz, H; Seeland, C; Stein, B | 1 |
| Conti, A; Dionisotti, S; Gatta, F; Ongini, E; Sandoli, D; Zocchi, C | 1 |
| Currin, RT; Lemasters, JJ; Lichtman, SN; Reinstein, LJ; Thurman, RG; Wang, J | 1 |
| Kapeghian, JC; Lasinski, ER; Matheson, DW; Mattes, WB; O'Lone, SD; Puri, EC | 1 |
| Kroll, K; Schrader, J | 1 |
| Ahlberg, S; Fredholm, BB; Olsson, RA; Parkinson, FE; van der Ploeg, I | 1 |
| Baraldi, PG; Dionisotti, S; Ferrara, S; Ongini, E; Zocchi, C | 1 |
| Dobson, JG; Fenton, RA; Sawmiller, DR | 1 |
| Brooks, R; Collis, MG; Keddie, JR; Poucher, SM; Shaw, GR | 1 |
| Hourani, SM; Prentice, DJ | 2 |
| Jacobson, KA; Ji, XD; Kim, YC | 1 |
| Andersson, RG; Bengtsson, T; Grenegård, M; Gustafsson, MC | 1 |
| Anderson, GF; Barraco, RA; Helfman, CC | 1 |
| Fredholm, BB; Lindström, K; Ongini, E | 1 |
| De Sarro, A; De Sarro, G; Donato Di Paola, E; Falconi, U; Ferreri, G | 1 |
| Poucher, SM | 1 |
| Dobson, JG; Ethier, MF | 1 |
| Abbracchio, MP; Jacobson, KA; Jiang, JL; Kim, YC; Sei, Y; Yao, Y | 1 |
| Jones, CA; Reeves, JJ; Sheehan, MJ; Vardey, CJ; Whelan, CJ | 1 |
| Dixon, AK; Richardson, PJ; Widdowson, L | 1 |
| Cristalli, G; Morelli, M; Pinna, A; Wardas, J | 1 |
| Apasov, S; Huang, S; Kojima, H; Koshiba, M; Sitkovsky, MV | 1 |
| Alexander, SP; Cooper, J; Hill, SJ | 1 |
| Constantino, MD; Cunha, RA; Ribeiro, JA | 2 |
| Hourani, SM; Payne, SL; Prentice, DJ | 1 |
| Fukamachi, H; Nakahata, T; Suzuki, H; Takei, M | 1 |
| Dionisotti, S; Fredholm, BB; Lindström, K; Ongini, E | 1 |
| Conforti, L; Kobayashi, S; Millhorn, DE; Pun, RY | 1 |
| Belardinelli, L; Dennis, DM; Lozza, G; Monopoli, A; Olsson, RA; Ongini, E; Shryock, JC; Snowdy, S; Zhang, Y | 1 |
| Betti, L; Biagi, G; Giannaccini, G; Giorgi, I; Livi, O; Lucacchini, A; Manera, C; Scartoni, V | 1 |
| Biaggioni, I; Feoktistov, I | 1 |
| Coney, AM; Marshall, JM | 1 |
| Jones, PA; Smith, RA; Stone, TW | 2 |
| Baraldi, PG; Borea, PA; Cacciari, B; Dionisotti, S; Ongini, E; Varani, K | 1 |
| Baker, SP; Baraldi, PG; Belardinelli, L; Cacciari, B; Monopoli, A; Ongini, E; Shryock, JC; Snowdy, S; Spalluto, G | 1 |
| O'Regan, MH; Phillis, JW; Song, D | 1 |
| Bryan, PT; Marshall, JM | 1 |
| O'Kane, EM; Stone, TW | 1 |
| Cutler, BS; Dobson, JG; Fenton, RA; Li, Jm; Peyton, BD; Powell, CC; Wheeler, HB | 1 |
| Arslan, G; Fredholm, BB; Kull, B; Lorenzen, A; Nilsson, C; Owman, C; Schwabe, U | 1 |
| Chung, ES; Dobson, JG; Fenton, RA; Honeyman, TW; Lorbar, M; McGinn, RJ; Meyer, TE; Norton, GR; Woodiwiss, AJ | 1 |
| Cseppentö, A; Kovács, P; Nagy, E; Szabó, JZ; Szentmiklósi, AJ; Ujfalusi, A | 1 |
| Bloch, B; Fourreau, L; Fredholm, BB; Gonon, F; Le Moine, C; Svenningsson, P | 1 |
| Jahania, MS; Kraft, KR; Lasley, RD; Mentzer, RM; Narayan, P; Partin, EL | 1 |
| Hata, K; Kloner, RA; Przyklenk, K; Whittaker, P | 1 |
| Cunha, RA; Lopes, LV; Ribeiro, JA | 2 |
| Fredholm, BB; Lindström, K | 1 |
| Buster, BL; Linden, J; Scheld, WM; Sullivan, GW | 1 |
| Kopf, SR; Melani, A; Pedata, F; Pepeu, G | 1 |
| Dale, TJ; Dupere, JR; Starkey, SJ; Xie, X | 1 |
| Bordoni, F; Corradetti, R; Latini, S; Pedata, F; Pepeu, G | 1 |
| Enyeart, JJ; Xu, L | 1 |
| Brunsden, AM; Grundy, D | 1 |
| Davie, CS; Everitt, DE; Standen, NB | 1 |
| Fei, Q; Loutzenhiser, R; Parker, M; Tang, L | 1 |
| Borgeat, P; Bourgoin, SG; Harbour, D; Naccache, PH; Thibault, N | 1 |
| Harada, N; Katsuragi, T; Okajima, K | 1 |
| Dashwood, MR; Spyer, KM; St Lambert, JH; Thomas, T | 1 |
| Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM | 1 |
| Abbracchio, MP; Cattabeni, F | 1 |
| Abebe, W; Arif Hasan, AZ; Mustafa, SJ | 1 |
| Jabbari-T, J; Oberhauser, V; Rump, LC; von Kügelgen, I | 1 |
| Gean, PW; Lu, KT; Wu, SP | 1 |
| Abbracchio, MP; Barbieri, D; Brambilla, R; Cattabeni, F; Ceruti, S; Franceschi, C; Jacobson, KA; Kim, YC; Klotz, KN; Lohse, MJ | 1 |
| Cunha, RA; Pereira, MF; Ribeiro, JA | 1 |
| Baraldi, PG; Borea, PA; Cacciari, B; Gessi, S; Klotz, KN; Leung, E; Merighi, S; Romagnoli, R; Spalluto, G; Varani, K | 1 |
| Bar-Yehuda, S; Barer, F; Farbstein, T; Fishman, P; Ohana, G | 1 |
| Albrizio, S; D'Ursi, A; Galoppini, C; Giusti, L; Greco, G; Hamm, HE; Lucacchini, A; Mazzoni, MR; Novellino, E; Rovero, P; Taddei, S; Triolo, A | 1 |
| Anderson, R; Ramafi, G; Theron, AJ; Visser, SS | 1 |
| Olah, ME; Roudabush, FL | 1 |
| Agostinho, P; Cunha, RA; Melo, J; Oliveira, CR; Rego, AC | 1 |
| Matsuki, N; Nakazawa, K; Ohno, Y; Sato, K | 1 |
| Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, J | 1 |
| Feoktistov, I; Mustafa, SJ; Olanrewaju, HA; Qin, W; Scemama, JL | 1 |
| Bianchi, L; Corsi, C; Melani, A; Pedata, F | 1 |
| Harada, N; Katsuragi, T; Murakami, K; Ohshima, K; Okajima, K; Sato, C; Usune, S | 1 |
| Brand, A; Eschke, D; Nieber, K; Vissiennon, Z | 1 |
| Koos, BJ; Maeda, T | 2 |
| Kaszkin, M; Pfeilschifter, J; Scholz-Pedretti, K | 1 |
| Hein, TW; Kuo, L; Muthuchamy, M; Wang, W; Zoghi, B | 1 |
| Linden, J; Macdonald, TL; Rieger, JM; Scheld, WM; Sullivan, GW | 1 |
| Khoo, HE; Mittal, RA; Tan, CH | 1 |
| Coyne, EF; Meno, JR; Ngai, AC; West, GA; Winn, HR | 1 |
| Jan, C; Koos, BJ; Maeda, T | 1 |
| Baker, SP; Belardinelli, L; Blackburn, B; Elzein, E; Gao, Z; Lasley, RD; Li, Z; Meyer, S; Palle, V; Zablocki, JA | 1 |
| Chen, Y; Hertz, L; Rathbone, MP | 1 |
| Bernardi, G; Calabresi, P; Centonze, D; Pisani, A; Saulle, E | 1 |
| Nikbakht, MR; Stone, TW | 1 |
| Hamann, M; Richter, A | 1 |
| Brookins, J; Fisher, JW | 1 |
| Breschi, MC; Calderone, V; Martinotti, E; Nieri, P | 1 |
| Inoue, H; Kikkawa, K; Mochida, H; Noto, T | 1 |
| Edmunds, NJ; Marshall, JM | 1 |
| Baldwin, SA; Cass, CE; Duszyk, M; Man, SF; Ng, AM; Sawicka, J; Szkotak, AJ; Young, JD | 1 |
| Costentin, J; El Yacoubi, M; Ledent, C; Ongini, E; Parmentier, M; Vaugeois, JM | 1 |
| Harvey, V; Jones, J; Knight, AR; Misra, A; Quirk, K | 1 |
| Furue, H; Kumamoto, E; Lao, LJ; Luo, C; Yoshimura, M | 1 |
| Ashton, K; Berr, SS; Cerniway, RJ; Harrison, GJ; Headrick, JP; Paul Matherne, G; Peart, J; Regan, S | 1 |
| Ijzerman, AP; Timmerman, H; van Muijlwijk-Koezen, JE | 1 |
| Higashi, H; Marwaha, AS; Meno, JR; Winn, HR | 1 |
| Baraldi, PG; Borea, PA; Cattabriga, E; Gessi, S; Iannotta, V; Leung, E; Merighi, S; Varani, K | 1 |
| Baraldi, PG; Borea, PA; Gessi, S; Klotz, KN; Leung, E; Merighi, S; Varani, K | 1 |
| Ellis, KM; Fozard, JR; Mazzoni, L; Tigani, B; Villela Dantas, MF | 1 |
| Jacobson, KA; Jacobson, MA; Ledent, C; Morrison, RR; Mustafa, SJ; Talukder, MA | 1 |
| Bivalacqua, TJ; Champion, HC; Kadowitz, PJ; Lambert, DG | 1 |
| Bonfanti, A; Marchi, M; Monopoli, A; Ongini, E; Raiteri, L; Raiteri, M; Risso, F; Vallarino, A | 1 |
| Cunha, RA; Fredholm, BB; Kull, B; Lopes, LV; Ribeiro, JA | 1 |
| Belem, PC; Chen, JF; Cronstein, B; Elson, G; Fink, JS; Jacobson, M; Leibovich, SJ; Montesinos, C; Pinhal-Enfield, G; Ramanathan, M; Rosania, A; Schwarzschild, MA | 1 |
| Gao, ZG; IJzerman, AP; Jacobson, KA; Kim, SG; Melman, N; Soltysiak, KA | 1 |
| Bril, A; Broadley, KJ; Khandoudi, N; Maddock, HL | 1 |
| Bastia, E; Bertorelli, R; Monopoli, A; Varani, K | 1 |
| Bibb, JA; Fienberg, AA; Fisone, G; Fredholm, BB; Greengard, P; Kim, Y; Lindskog, M; Nairn, AC; Pozzi, L; Svenningsson, P | 1 |
| Le Crom, S; Prou, D; Vernier, P | 1 |
| Brackenborough, KT; Duffy, C; Hagan, RM; Jones, SA; Morgan, PF; Pratt, GD; Sargent, RS; Southam, E; Stratton, SC | 1 |
| Ezeamuzie, CI; Philips, E | 1 |
| Feldkamp, T; Heemann, U; Herget-Rosenthal, S; Horbelt, M; Kribben, A; Lange, B; Philipp, T; Pietruck, F | 1 |
| Diniz, C; Gonçalves, J; Leal, S | 1 |
| Almeida, CG; Cunha, RA; de Mendonça, A; Ribeiro, JA | 1 |
| Antoniou, K; Ferré, S; Fuxe, K; Goldberg, SR; Justinova, Z; Karcz-Kubicha, M; Müller, CE; Pezzola, A; Popoli, P; Quarta, D; Reggio, R; Solinas, M; Terasmaa, A | 1 |
| Saccone, GT; Toouli, J; Woods, CM | 1 |
| Adamski, D; Berger, F; Charles, MP; Kholler, B; Pelletier, L; Wion, D | 1 |
| Hague, BF; Kindt, TJ; Zhao, TM | 1 |
| Boehm, S; Freissmuth, M; Just, H; Klinger, M; Korkhov, VM; Kudlacek, O; Nanoff, C; Pankevych, H; Vartian, N; Yang, Q | 1 |
| Abbracchio, MP; Brambilla, R; Ceruti, S; Cottini, L; Fumagalli, M | 1 |
| Fredholm, BB; Hellsten, Y; Lynge, J; Nordsborg, N; Schulte, G | 1 |
| Corsi, C; Gianfriddo, M; Melani, A; Pedata, F; Pèzzola, A; Popoli, P; Reggio, R | 1 |
| Berrino, L; Capuano, A; De Novellis, V; Filippelli, A; Mazzeo, F; Rossi, F; Stella, L; Vitelli, MR | 1 |
| Cunha, RA; de Mendonca, A; Oliveira, CR; Rebola, N; Ribeiro, JA; Sebastião, AM | 1 |
| O'Regan, MH; Phillis, JW | 1 |
| Brodmann, M; Lischnig, U; Lueger, A; Pilger, E; Stark, G | 1 |
| Addae, JI; Stone, TW; Youssef, FF | 1 |
| Fredholm, BB; Svenningsson, P | 1 |
| Costentin, J; El Yacoubi, M; Vaugeois, JM | 1 |
| Benwell, K; Cliffe, IA; Dourish, CT; Gillespie, RJ; Knight, AR; Lerpiniere, J; Misra, A; Pratt, RM; Revell, D; Upton, R; Weiss, SM | 1 |
| Brooke, RE; Deuchars, J; Deuchars, SA | 1 |
| Goulart, EC; Kaster, MP; Rodrigues, AL; Rosa, AO; Rosso, MM; Santos, AR | 1 |
| Kwok, YN; Yip, L | 1 |
| Abebe, W; Mozaffari, MS | 1 |
| Easton, AS; Inglis, VI; Jones, MP; Tse, AD | 1 |
| Catarzi, D; Colotta, V; Filacchioni, G; Lucacchini, A; Martini, C; Trincavelli, L; Varano, F | 2 |
| Chen, JF; Cunha, RA; Fredholm, BB; Halldner, L; Johansson, B; Ledent, C; Lopes, LV; Rebola, N | 1 |
| Diógenes, MJ; Fernandes, CC; Ribeiro, JA; Sebastião, AM | 1 |
| Etherington, LA; Frenguelli, BG | 1 |
| Ho, CM; Ho, ST; Peng, SC; Su, CK; Tsai, SK | 1 |
| Awadallah, NW; Chan, ES; Cronstein, BN; Montesinos, MC; Rahman, MM; Reiss, AB | 1 |
| Domenici, MR; Frank, C; Grieco, R; Martire, A; Pepponi, R; Pintor, A; Popoli, P; Potenza, RL; Tebano, MT | 1 |
| Barbu, DE; Lungu, CL; O'Regan, MH; Phillis, JW | 1 |
| Diniz, C; Fresco, P; Gonçalves, J | 1 |
| Domenici, MR; Martire, A; Pepponi, R; Popoli, P; Potenza, RL; Tebano, MT | 1 |
| Gianfriddo, M; Giovannini, MG; Melani, A; Pedata, F; Turchi, D | 1 |
| Batista, LC; Prediger, RD; Takahashi, RN | 1 |
| Abbracchio, MP; Ceruti, S; Marroni, M; Martini, C; Mazzola, A; Mitro, N; Trincavelli, ML; Tuscano, D | 1 |
| Colgan, SP; Eltzschig, HK; Ibla, JC; Morote-Garcia, JC; Resta, R; Thompson, LF; Van De Wiele, CJ | 1 |
| Lappas, CM; Linden, J; Rieger, JM | 1 |
| Briones, R; Donoso, MV; Huidobro-Toro, JP; López, R; Miranda, R | 1 |
| Alfaro, TM; Cunha, RA; Oliveira, CR; Rebola, N; Rodrigues, RJ | 1 |
| Fuxe, K; Rinken, A; Terasmaa, A; Uustare, A; Vonk, A | 1 |
| Ackley, MA; Baldwin, SA; King, AE | 1 |
| Abbracchio, MP; Camurri, A; Capecchi, PL; Diciolla, F; Laghi-Pasini, F; Lazzerini, PE; Maccherini, M; Mazzola, A; Pompella, G | 1 |
| Prediger, RD; Takahashi, RN | 1 |
| Baharav, E; Bar-Yehuda, S; Fishman, P; Halpren, M; Madi, L; Ochaion, A; Rath-Wolfson, L; Silberman, D; Weinberger, A | 1 |
| Hikichi, T; Kawahara, A; Kitaya, N; Mori, F; Takahashi, J; Yoshida, A | 1 |
| Bonan, CD; Cammarota, M; Izquierdo, I; Pereira, GS; Rossato, JI; Sarkis, JJ | 1 |
| Arun, KH; Kaul, CL; Kumar, S; Sharma, SS | 1 |
| Coelho, JE; Cunha, RA; Pinto-Duarte, A; Ribeiro, JA; Sebastião, AM | 1 |
| Andrisani, OM; Bilodeau, ML; Ji, M; Paris, M | 1 |
| Sladek, CD; Song, Z | 1 |
| Amerson, BS; Guyton, RA; Halkos, ME; Headrick, JP; Kerendi, F; Kin, H; Lofye, MT; Vinten-Johansen, J; Zatta, AJ; Zhao, ZQ | 1 |
| Asplund Persson, A; Bengtsson, T; Grenegård, M; Lindström, E; Whiss, PA; Zalavary, S | 1 |
| Cavalheiro, EA; da Silva Fernandes, MJ; Doná, F; Ferreira, AT; Vianna, EP | 1 |
| Angulo, E; Casadó, V; Chen, JF; Ejarque, A; Franco, R; Lluis, C; Moratalla, R; Saura, J; Schwarzschild, MA; Serratosa, J; Tusell, JM | 1 |
| Marshall, JM; Ray, CJ | 3 |
| Deussen, A; Frøbert, O; Gravholt, CH; Haink, G; Levin, M; Simonsen, U | 1 |
| Fathollahi, Y; Mirnajafi-Zadeh, J; Namvar, S; Rezvani, ME; Zeraati, M | 1 |
| Cortés, D; Díaz-Cruz, A; Guinzberg, R; Piña, E; Riveros-Rosas, H; Villalobos-Molina, R | 1 |
| Allen-Gipson, DS; Sisson, JH; Spurzem, JR; Wong, J; Wyatt, TA | 1 |
| Antonioli, L; Blandizzi, C; Colucci, R; Del Tacca, M; Fornai, M; Ghisu, N | 1 |
| Cheng, JJ; Huang, NK; Lai, WL; Lin, YR; Lu, MK | 1 |
| Baghdoyan, HA; Coleman, CG; Lydic, R | 1 |
| Bennett, MR; Lin, YQ | 1 |
| Broadley, KJ; Clark, JH; James, S; Kidd, EJ; Martin, TJ; Yates, L | 1 |
| Benini, A; Borea, PA; Gessi, S; Leung, E; Maclennan, S; Merighi, S; Mirandola, P; Varani, K | 1 |
| Aceves, J; Erlij, D; Florán, B; Florán, L; Gonzalez, B; Paz, F | 1 |
| Greengard, P; Higashi, H; Kuroiwa, M; Nishi, A; Shuto, T; Snyder, GL; Sotogaku, N; Tanaka, M; Yabuuchi, K | 1 |
| Koos, BJ; Kruger, L; Linden, J; Murray, TF; Yan, X | 1 |
| Chan, ES; Chen, JF; Cronstein, BN; Delano, DL; Desai, A; Fernandez, P; Friedman, SL; Montesinos, MC; Pillinger, MH; Reiss, AB; Schwarzschild, MA; Yee, H | 1 |
| Gao, ZG; Jacobson, KA; Jeong, LS; Kim, SK | 1 |
| Chuaychoo, B; Kollarik, M; Lee, MG; Pullmann, R; Undem, BJ | 1 |
| Conde, SV; Gonzalez, C; Obeso, A; Rigual, R; Rocher, A; Vicario, I | 1 |
| Brown, R; Fredholm, BB; Lai, EY; Mrowka, R; Patzak, A; Persson, AE; Persson, PB; Spielmann, N; Steege, A | 1 |
| Huxley, VH; Wang, J | 1 |
| Mulè, F; Serio, R; Zizzo, MG | 1 |
| Gomes, CA; Ribeiro, JA; Sebastião, AM; Vaz, SH | 1 |
| Auchampach, JA; Ge, ZD; Gross, GJ; Jacobson, MA; Kreckler, LM; Peart, JN; Wan, TC | 1 |
| Grden, M; Kocbuch, K; Pawelczyk, T; Podgorska, M; Szutowicz, A | 1 |
| Gao, C; Gao, N; Hu, HZ; Liu, S; Wood, JD; Xia, Y | 1 |
| Cunha-Reis, D; Fontinha, BM; Ribeiro, JA; Sebastião, AM | 1 |
| Cosyn, L; Duong, HT; Gao, ZG; Jacobson, KA; Kim, SK; Palaniappan, KK; Van Calenbergh, S | 1 |
| Alexander, SP; Barrett, DA; Cordell, R; Ralevic, V; Rayment, SJ | 1 |
| Fatokun, AA; Smith, RA; Stone, TW | 1 |
| Jenner, P; Ramsay Croft, N; Rose, S | 1 |
| Belardinelli, L; Chu, N; Diamond, I; Kalla, R; Leung, K; Shryock, JC; Soelaiman, S; Soohoo, D; Yang, M; Yao, L; Zablocki, J | 1 |
| Biskup, W; Celiński, K; Cichoz-Lach, H; Czechowska, G; Korobowicz, E; Korolczuk, A; Madro, A; Prozorow-Król, B; Słomka, M | 1 |
| Bradding, P; Brightling, CE; Cruse, G; Duffy, SM | 1 |
| Carneiro, FS; Giachini, FR; Inscho, EW; Leite, R; Tostes, RC; Webb, RC | 1 |
| Adams, CL; Cowen, MS; Lawrence, AJ; Short, JL | 1 |
| Fathollahi, Y; Hosseinmardi, N; Mirnajafi-Zadeh, J; Shahabi, P | 1 |
| Hofmann, PA; Ledent, C; Morrison, RR; Mustafa, SJ; Tan, XL | 1 |
| Hamano, R; Iwagaki, H; Kanke, T; Liu, K; Nishibori, M; Sendo, T; Takahashi, HK; Tanaka, N; Yoshino, T | 1 |
| Fathollahi, Y; Mirnajafi-Zadeh, J; Palizvan, MR; Rezvani, ME | 1 |
| Baranyi, M; Illes, P; Sperlágh, B; Vizi, ES; Zsilla, G | 1 |
| Belcastro, V; Borsini, F; Calabresi, P; Centonze, D; Costa, C; Picconi, B; Tantucci, M; Tozzi, A; Tscherter, A | 1 |
| Cao, Z; Hurley, DJ; Linden, J; Moore, JN; Murray, TF; Sun, WC; Vandenplas, ML | 1 |
| Desfrere, L; Gressens, P; Olivier, P; Schwendimann, L; Verney, C | 1 |
| Cunha, RA; Lujan, R; Mulle, C; Rebola, N | 1 |
| Binfaré, RW; Budni, J; Lobato, KR; Rodrigues, AL; Rosa, AO; Santos, AR | 1 |
| Cheng, KT; Huang, Y; Kwan, HY; Kwok, YC; Leung, YK; Ma, X; Man, YB; Shen, B; Wong, CO; Yao, X | 1 |
| Coskun, C; Mutlu, D; Savci, V; Suzer, O; Yalcin, M; Yilmaz, MS | 1 |
| Diógenes, MJ; Fontinha, BM; Ribeiro, JA; Sebastião, AM | 1 |
| Coe, IR; Naydenova, Z; Rose, JB | 1 |
| Blackburn, MR; Chan, ES; Chiriboga, L; Cronstein, BN; Fernández, P; Trzaska, S; Wilder, T | 1 |
| Boyle, CD; Chackalamannil, S; Cohen-Williams, ME; Greenlee, WJ; Higgins, GA; Lachowicz, JE; Lankin, CM; Neustadt, BR; Ng, K; Shah, U; Varty, GB; Zhang, H | 1 |
| Bizzoco, E; Cipriani, S; Gianfriddo, M; Melani, A; Pedata, F; Vannucchi, MG | 1 |
| Casanello, P; Escudero, C; Sobrevia, L | 1 |
| Ansari, HR; Falck, JR; Ledent, C; Mustafa, SJ; Nayeem, MA; Poloyac, SM; Ponnoth, DS; Zeldin, DC | 1 |
| Arcella, A; Cantore, G; Di Gennaro, G; Esposito, V; Eusebi, F; Fredholm, BB; Fucile, S; Limatola, C; Manfredi, M; Martinello, K; Mascia, A; Miledi, R; Piccari, V; Quarato, PP; Roseti, C; Simonato, M | 1 |
| Bendor, J; Flajolet, M; Futter, M; Greengard, P; Nairn, AC; Nuangchamnong, N; Shen, W; Surmeier, DJ; Wallach, I; Wang, Z | 1 |
| Hamilton, JB; Lancaster, DM; Patel, N; Pietersen, AN; Vreugdenhil, M | 1 |
| Aldrich, CC; Barry, CE; Boshoff, HI; Gupte, A; Labello, NP; Neres, J; Somu, RV; Wilson, DJ; Xing, C | 1 |
| Antunes, C; Böhmer, AE; Elisabetsky, E; Lara, DR; Porciúncula, LO; Schallenberger, C; Schmidt, AP; Souza, DO | 1 |
| Carlström, M; Lai, EY; Patzak, A; Persson, AE | 1 |
| Baghdoyan, HA; Lydic, R; Van Dort, CJ | 1 |
| Ichinose, TK; O'Leary, DS; Scislo, TJ | 1 |
| Miriel, VA; Rivers, RJ; Thengchaisri, N | 1 |
| Church, JE; Coupar, IM; Pouton, CW; Rose'Meyer, RB; Urmaliya, VB; White, PJ | 1 |
| Cipriani, S; Galli, A; Gianfriddo, M; Giovannini, MG; Mello, T; Pedata, F; Pugliese, AM; Traini, C | 1 |
| Bertram, EH; Hargus, NJ; Patel, MK | 1 |
| Csóka, B; Haskó, G; Leibovich, SJ; Lukashev, D; Luo, W; Ramanathan, M; Sitkovsky, MV | 1 |
| Batchelor, DV; Chavaroche, H; Lemaitre, A; Macintyre, F; Mantell, SJ; Maw, GN; Monaghan, SM; Rozze, S; Selby, MD; Stephenson, PT; Stuart, EF; Trevethick, MA; Walker, DK; Whitlock, L; Wright, KN; Wright, PA; Yeadon, M | 1 |
| Jalali, A; Kawa, K; Larsen, C; Trevitt, J | 1 |
| Ballerini, P; Biagioni, F; Buccella, S; Caciagli, F; Ciccarelli, R; Citraro, R; D'Alimonte, I; D'Auro, M; De Sarro, G; Di Iorio, P; Giuliani, P; Jiang, S; Nargi, E; Russo, E | 1 |
| Krahn, T; Ledent, C; Mustafa, SJ; Ponnoth, DS; Roush, K; Sanjani, MS | 1 |
| Aung, HH; Barnholt, KE; Kota, RS; Rutledge, JC | 1 |
| Bernstein, SH; Burack, WR; Cochran, MR; Hilchey, SP; Hyrien, O; Kobie, JJ; Mosmann, TR; Quataert, SA; Secor-Socha, S; Wang, JC | 1 |
| Aronhime, SN; Chen, JF; Echeverry, G; Kulik, TB; Kusano, Y; Miekisiak, G; Winn, HR | 1 |
| Devaux, Y; Ernens, I; Léonard, F; Rolland-Turner, M; Vausort, M; Wagner, DR | 1 |
| Chen, SR; Li, DP; Pan, HL | 1 |
| Barrett, MO; Chinn, M; Fricks, IP; Gao, ZG; Harden, TK; Hong, K; Jacobson, KA; Kilbey, SM; Tosh, DK; Yoo, LS | 1 |
| Cairo, G; Gammella, E; Tacchini, L | 1 |
| Curiel, TJ; Daniel, BJ; Fan, J; Jin, D; Liu, A; Shin, T; Thompson, LF; Wang, L; Zhang, B | 1 |
| Pao, AC; Rajagopal, M | 1 |
| Feng, MG; Navar, LG | 1 |
| Carlström, M; Welch, WJ; Wilcox, CS | 1 |
| Bouïs, D; Changelian, PS; Harada, H; Lama, VN; Noon, K; Ohtsuka, T; Pinsky, DJ | 1 |
| Attolini, M; Berthault, A; By, Y; Carrega, L; Chouraqui, G; Commeiras, L; Condo, J; Gaudel-Siri, A; Guieu, R; Mathew, SC; Parrain, JL; Rodriguez, J; Ruf, J; Virolleaud, MA | 1 |
| Li, GQ; Lu, HH; Mo, Q; Qian, J; Tang, LM; Wang, F; Wang, XH; Zhu, J; Zhu, JF | 1 |
| Fredholm, BB; Hao, JX; Li, L; Schulte, G; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Barodia, SK; Kumari, N; Luthra, PM; Mishra, CB; Prakash, A; Senthil Kumar, JB | 1 |
| Ledent, C; Pouton, CW; Short, JL; Urmaliya, VB; White, PJ | 1 |
| Berwick, ZC; Dick, GM; Lynch, B; Payne, GA; Sturek, M; Tune, JD | 1 |
| Che, PL; Du, J; Ha, B; Wang, Z; Yarema, KJ | 1 |
| Cherezov, V; Gao, ZG; Han, GW; Jacobson, KA; Katritch, V; Stevens, RC; Wu, H; Xu, F | 1 |
| Bramanti, P; Cipriani, S; Corti, F; Cuzzocrea, S; Esposito, E; Mazzon, E; Melani, A; Mello, T; Paterniti, I; Pedata, F | 1 |
| Chen, JF; Feng, L; Garcia, GE; Johnson, RJ; Truong, LD | 1 |
| Choukèr, A; Feuerecker, M; Kaufmann, I; Salam, A; Schelling, G; Thiel, M | 1 |
| Bennett, K; Edwards, PC; Langmead, CJ; Lebon, G; Leslie, AG; Tate, CG; Warne, T | 1 |
| Agostinho, PM; Canas, PM; Costenla, AR; Cunha, RA; de Mendonça, A; Diógenes, MJ; Maroco, J; Nogueira, C; Ribeiro, JA; Rodrigues, RJ | 1 |
| Cronstein, BN; Williams, AJ | 1 |
| Amorim, RP; de Oliveira, DM; Fernandes, MJ; Nehlig, A; Persike, DS; Rosim, FE | 1 |
| Li, W; Zhang, JJ | 1 |
| Biragyn, A; Ferrucci, L; Goetzl, EJ; Hesdorffer, CS; Kennedy, RT; Longo, DL; Mabrouk, OS; Madara, K; Malchinkhuu, E; Schwartz, JB; Taub, DD | 1 |
| Faldyna, M; Kovaru, F; Kovaru, H; Leva, L; Matiasovic, J; Ondrackova, P | 1 |
| Kang, RX; Li, M; Shi, JG; Sun, J; Zhang, JJ | 1 |
| Blank, J; Charlat, O; Cheng, H; Cheung, A; Chin, DN; Cong, F; Feng, Y; Fortin, PD; Hood, T; Kirby, CA; Shao, W; Shultz, MD; Stams, T; Tyagi, V; Xu, M; Zhang, B | 1 |
| Broz, V; Dolezal, V; Fleischmannova, J; Kucerova, L; Santruckova, E; Sidorov, R; Zurovec, M | 1 |
| Folkesson, HG; Kuzenko, SR; Lipson, DA; Matthay, MA; Simmons, MA | 1 |
| Blanco, C; Colettis, N; Hartley, RC; Harvey, AL; Jamieson, AG; Jerusalinsky, D; Kornisiuk, E; Snitcofsky, M; Stone, TW; Young, LC | 1 |
| Lochner, A; Moolman, JA; Salie, R | 1 |
| Burton, VJ; Butler, M; Parkinson, SJ; Pearson, R; Sanmugalingam, D; Smith, P; Watson, RP; Wilson, T | 1 |
| Falck, JR; Morisseau, C; Mustafa, SJ; Nayeem, MA; Pradhan, I; Zeldin, DC | 1 |
| Martins, DF; Mazzardo-Martins, L; Piovezan, AP; Santos, AR; Soldi, F; Stramosk, J | 1 |
| Ailawadi, G; Barbery, C; Bhamidipati, CM; Kron, IL; Laubach, VE; Meher, AK; Mehta, GS; Moehle, CW; Owens, GK; Sharma, AK; Su, G; Upchurch, GR; Vigneshwar, NG | 1 |
| An, JH; Chen, JF; Dai, SS; Li, W; Ning, YL; Wang, H; Yang, N; Zhou, YG; Zhu, PF | 1 |
| Ding, X; Li, T; Liu, L; Peng, X; Yang, G; Zhu, Y | 1 |
| Alam, MN; Hsieh, KC; Kumar, S; McGinty, D; Rai, S; Szymusiak, R | 1 |
| Agostinho, P; Castro, AA; Cunha, RA; Garção, P; Köfalvi, A; Prediger, RD; Szabó, EC; Tomé, ÂR; Wopereis, S | 1 |
| Cellai, L; Coppi, E; Maraula, G; Pedata, F; Pugliese, AM | 1 |
| Augusto, E; Bynoe, MS; Chen, JF; Cunha, RA; El-Tayeb, A; Matos, M; Müller, CE; Sévigny, J | 1 |
| Carter, EL; Heitmiller, KD; Hong, G; Jamrogowicz, JL; Koehler, RC; Kwansa, H; Larson, AC; Martin, LJ; Wang, B; Yang, ZJ | 1 |
| Bernardo, A; De Nuccio, C; Ferrante, A; Minghetti, L; Pepponi, R; Popoli, P; Visentin, S | 1 |
| Minic, Z; O'Leary, DS; Scislo, TJ | 1 |
| Boiko, N; Chimote, AA; Conforti, L; Hajdu, P; Kucher, V; Kuras, Z; Szilagyi, O; Yun, YH | 1 |
| Agostinho, P; Augusto, E; Chen, JF; Cunha, RA; Matos, M | 1 |
| Frøbert, O; Hedegaard, ER; Mogensen, S; Nielsen, BD; Rembold, CM; Simonsen, U | 1 |
| Diógenes, MJ; Jerónimo-Santos, A; Rodrigues, TM; Sebastião, AM | 1 |
| Exley, M; Kini, R; Madasu, M; Nowak, M; Ohta, A; Sitkovsky, M; Subramanian, M | 1 |
| Arias-Montaño, JA; Escamilla-Sánchez, J; González-Pantoja, R; Márquez-Gómez, R; Morales-Figueroa, GE | 1 |
| Birnbaum, Y; Kodakandla, M; Ling, S; Nanhwan, MK; Nylander, S; Ye, Y | 1 |
| Filip, M; Fuxe, K; Gołembiowska, K; Kamińska, K; Suder, A; Wydra, K | 1 |
| Ledent, C; Mustafa, SJ; Teng, B; Tilley, S; Zhou, X | 1 |
| Bai, XY; Du, GH; Hao, LH; Huang, ZL; Liu, R; Sun, ZM; Wu, S; Zhang, WK; Zhang, XQ; Zhang, YH | 1 |
| Chang, NC; Chen, WT; Lee, TM; Lin, SZ; Yang, CC | 1 |
| Cataño-Cañizalez, YG; Cortés-Garcia, JD; Cortez-Espinosa, N; Guzman-Flores, JM; Portales-Perez, DP; Rodríguez-Rivera, JG; Vargas-Morales, JM | 1 |
| Cristóvão, G; Cunha, RA; George, J; Gomes, CA; Gonçalves, FQ; Gonçalves, T; Meyer Fernandes, JR; Rodrigues, L | 1 |
| Konieczny, V; Sureshan, KM; Taylor, CW; Vibhute, AM | 1 |
| Almeida, AS; Botton, PH; Chenet, GC; Cunha, RA; Loss, CM; Marques, DM; Mioranzza, S; Nunes, F; Pagnussat, N; Porciúncula, LO | 1 |
| Bartoccini, F; Bassi, M; Borsini, F; Brogin, G; Cabri, W; Capocasa, F; Grossi, P; Lucarini, S; Manera, F; Minetti, P; Pace, S; Piersanti, G; Riccioni, T; Stasi, MA; Tallarico, C; Tarzia, G; Vacondio, F | 1 |
| Hiromura, M; Honda, S; Inoue, K; Kosako, K; Kuroki, H; Shiratani, T; Soeda, S; Toda, A; Uchiyama, H | 1 |
| Borroto-Escuela, DO; Franco, R; Fuxe, K; Navarro, G | 1 |
| Cortés-Garcia, JD; Cortez-Espinosa, N; García-Hernández, MH; Guzmán-Flores, JM; Layseca-Espinosa, E; López-López, C; Portales-Cervantes, L; Portales-Pérez, DP | 1 |
| Diógenes, MJ; Lérias, SR; Parreira, S; Sebastião, AM; Vaz, SH | 1 |
| Jia, SB; Shi, JG; Zhang, JJ; Zhang, Y | 1 |
| Brozmanova, M; Hu, Y; Kollarik, M; Mazurova, L; Ru, F; Tatar, M; Yu, S | 1 |
| Alves, PM; Alves, RM; Conde, SV; Queiroga, CS; Vieira, HL | 1 |
| Cherasse, Y; de Kerchove d'Exaerde, A; Huang, ZL; Lavielle, O; Lazarus, M; Li, R; McEown, K; Qu, WM; Schiffmann, SN; Wang, DR; Wang, YQ; Zhang, MQ; Zhang, Z | 1 |
| Bonaventura, J; Brugarolas, M; Casadó, V; Cellai, L; Chang, CP; Chern, Y; Cortés, A; Dettori, I; Ferré, S; Guitart, X; Narayanan, M; Orrú, M; Pedata, F; Rea, W | 1 |
| Bai, W; Chen, JF; Chen, X; Chen, XY; Li, P; Liu, D; Ning, YL; Peng, Y; Wang, H; Yang, N; Zhao, Y; Zhao, ZA; Zhou, YG | 1 |
| Bai, X; He, J; Li, T; Qiao, H; Xu, J; Ye, X; Zhang, J; Zhang, W | 1 |
| Fischer, L; Morais, RN; Sardi, NF; Tobaldini, G | 1 |
| Gładysz, M; Milecki, J; Ruszkowski, P | 1 |
| Ernst, OP; García, AE; Larda, ST; Lyda, B; Neale, C; Pichugin, D; Pomès, R; Prosser, RS; Sljoka, A; Sunahara, RK; Tsuchimura, N; Ye, L | 1 |
| Chen, L; Duan, W; Fan, Q; Huang, H; Ran, H; Wang, H | 1 |
| Ávila-Ibarra, LR; de Lourdes Mora-García, M; Del Carmen Fuentes-Castañeda, M; Don-López, CA; García-Rocha, R; Gutiérrez-Serrano, V; Hernández-Montes, J; Monroy-García, A; Torres-Pineda, DB; Weiss-Steider, B | 1 |
| Cao, J; Dong, Z; Li, W; Lin, H; Shi, Y; Xiao, R; Zhang, X | 1 |
| Babu, KS; Murthy, M; Velayutham, P | 1 |
| Cai, H; Cai, X; Chen, L; Chen, X; Han, X; Shi, H; Singh, BL; Wang, Y; Yu, C | 1 |
| Agostinho, P; Andrade, GM; Canas, PM; Carmo, M; Cunha, RA; Duarte, FV; Fernandes, FD; Gonçalves, FQ; Oses, JP; Palmeira, CM; Tomé, AR | 1 |
| Chen, X; Dai, X; Li, L; Miao, W; Wang, Y; Zhao, Y | 1 |
| Conde, SV; Gonzalez, C; Martins, FO; Melo, BF; Monteiro, EC; Olea, E; Prieto-Lloret, J; Ribeiro, MJ; Sacramento, JF | 1 |
| Gom, RC; Phillips, TJ; Teskey, GC; Wolff, MD | 1 |
| Buccioni, M; Coelho, JE; Dal Ben, D; Lambertucci, C; Lopes, LV; Marques-Morgado, I; Martí Navia, A; Marucci, G; Spinaci, A; Volpini, R | 1 |
| Atdjian, C; Braud, E; Coelho, D; Ethève-Quelquejeu, M; Iannazzo, L | 1 |
| Marchesi, E; Navacchia, ML; Perrone, D; Preti, L | 1 |
| Claff, T; Klapschinski, TA; Labahn, J; Müller, CE; Schlegel, JG; Tiruttani Subhramanyam, UK; Vaaßen, VJ; Vielmuth, C; Voß, JH | 1 |
| Brown, T; Cao, M; Zheng, YG | 1 |
4 review(s) available for triazoles and adenosine
| Article | Year |
|---|---|
The adenosine A3 receptor and its ligands.
Topics: Adenosine; Amino Acid Sequence; Animals; Cardiovascular Diseases; Cloning, Molecular; Flavonoids; Humans; Immune System Diseases; Lung Diseases; Models, Animal; Molecular Sequence Data; Protein Binding; Pyrans; Pyridines; Quinazolines; Receptors, Purinergic; Sequence Alignment; Species Specificity; Triazoles; Xanthines | 2001 |
Adenosine-dopamine interactions: development of a concept and some comments on therapeutic possibilities.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Corpus Striatum; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Humans; Mice; Nerve Tissue Proteins; Parkinson Disease; Phosphoproteins; Phosphorylation; Pyrimidines; Receptor, Adenosine A2A; Receptors, Dopamine D2; Signal Transduction; Triazoles | 2003 |
Purinergic signaling in Parkinson's disease. Relevance for treatment.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Basal Ganglia; Corpus Striatum; Humans; Parkinson Disease; Purine Nucleotides; Purines; Pyrimidines; Receptor, Adenosine A2A; Receptors, Dopamine D2; Signal Transduction; Triazoles | 2016 |
Modified Nucleosides, Nucleotides and Nucleic Acids via Click Azide-Alkyne Cycloaddition for Pharmacological Applications.
Topics: Adenosine; Alkynes; Animals; Azides; Cell Line, Tumor; Click Chemistry; Cycloaddition Reaction; DNA; ErbB Receptors; Humans; Mice; Nucleic Acids; Nucleosides; Nucleotides; Oligonucleotides, Antisense; Reproducibility of Results; RNA, Guide, Kinetoplastida; Technology, Pharmaceutical; Triazoles | 2021 |
2 trial(s) available for triazoles and adenosine
| Article | Year |
|---|---|
Impairment of adenosine A3 receptor activity disrupts neutrophil migratory capacity and impacts innate immune function in vivo.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Animals; Chemotaxis; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Immunity, Innate; Inflammation; Mice; Mice, Knockout; Neutrophils; Quinazolines; Receptor, Adenosine A3; Triazoles; Up-Regulation | 2012 |
Plasma glutamate-modulated interaction of A2AR and mGluR5 on BMDCs aggravates traumatic brain injury-induced acute lung injury.
Topics: Acute Lung Injury; Adenosine; Adenosine A2 Receptor Agonists; Adult; Animals; Bone Marrow Cells; Brain Injuries; Disease Models, Animal; Female; Glutamic Acid; Humans; Male; Mice; Mice, Knockout; Middle Aged; Phenethylamines; Protein Kinase C; Receptor, Adenosine A2A; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Signal Transduction; Triazines; Triazoles; Type C Phospholipases | 2013 |
367 other study(ies) available for triazoles and adenosine
| Article | Year |
|---|---|
Excitatory transmitter amino acid release from the ischemic rat cerebral cortex: effects of adenosine receptor agonists and antagonists.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Aspartic Acid; Brain Ischemia; Cerebral Cortex; Glutamates; Glutamic Acid; Male; Neurotransmitter Agents; Purinergic Antagonists; Quinazolines; Rats; Rats, Inbred Strains; Receptors, Purinergic; Triazoles; Xanthines | 1992 |
Selective adenosine-2 agonist produces both direct and reflex tachycardia in normotensive rats.
Topics: Adenosine; Adrenergic beta-Antagonists; Animals; Blood Pressure; Dose-Response Relationship, Drug; Ganglia, Sympathetic; Heart Rate; Male; Purinergic Antagonists; Quinazolines; Rats; Rats, Inbred Strains; Receptors, Purinergic; Sympathetic Nervous System; Triazoles; Vascular Resistance | 1992 |
Evidence that the increase in striatal c-fos following acute high-dose caffeine is not due to direct interaction with striatal adenosine receptors.
Topics: Adenosine; Animals; Caffeine; Corpus Striatum; Dose-Response Relationship, Drug; Genes, fos; Purinergic Antagonists; Quinazolines; Rats; RNA, Messenger; Triazoles; Xanthines | 1992 |
Influence of the adenosine receptor antagonist, CGS 15943A, on renal function after reconstruction of chronic renal artery stenosis in the dog.
Topics: Adenosine; Animals; Constriction, Pathologic; Creatinine; Dogs; Hemodynamics; Kidney; Purinergic Antagonists; Quinazolines; Renal Artery; Renal Circulation; Triazoles | 1992 |
Subtypes of adenosine receptors in the brainstem mediate opposite blood pressure responses.
Topics: Adenosine; Animals; Antihypertensive Agents; Blood Pressure; Brain Stem; Dose-Response Relationship, Drug; Male; Phenethylamines; Quinazolines; Rats; Rats, Inbred Strains; Receptors, Purinergic; Triazoles; Xanthines | 1991 |
Do adenosinergic substrates mediate methylxanthine effects upon reinforcement thresholds for electrical brain stimulation in the rat?
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Brain; Carbolines; Chlordiazepoxide; Electric Stimulation; Hypothalamic Area, Lateral; Male; Midazolam; Phenylisopropyladenosine; Quinazolines; Rats; Rats, Inbred Strains; Receptors, Purinergic; Reinforcement, Psychology; Self Stimulation; Sensory Thresholds; Theophylline; Triazoles | 1991 |
CGS 15943, a nonxanthine adenosine receptor antagonist: effects on locomotor activity of nontolerant and caffeine-tolerant rats.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Dose-Response Relationship, Drug; Drug Tolerance; Male; Motor Activity; Quinazolines; Rats; Rats, Inbred Strains; Triazoles | 1991 |
Influence of CGS 15943 A (a nonxanthine adenosine antagonist) on the protection offered by a variety of antiepileptic drugs against maximal electroshock-induced seizures in mice.
Topics: Adenosine; Animals; Anticonvulsants; Disease Susceptibility; Drug Interactions; Electroshock; Epilepsy; Male; Mice; Motor Activity; Quinazolines; Triazoles | 1991 |
Characterization of the binding of a novel nonxanthine adenosine antagonist radioligand, [3H]CGS 15943, to multiple affinity states of the adenosine A1 receptor in the rat cortex.
Topics: 2-Chloroadenosine; Adenosine; Animals; Binding, Competitive; Cerebral Cortex; Dose-Response Relationship, Drug; Phenylisopropyladenosine; Purinergic Antagonists; Pyrazoles; Quinazolines; Rats; Receptors, Purinergic; Triazoles; Tritium | 1991 |
Comparison of the behavioural effects of an adenosine A1/A2-receptor antagonist, CGS 15943A, and an A1-selective antagonist, DPCPX.
Topics: Adenosine; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Male; Mice; Motor Activity; Purinergic Antagonists; Quinazolines; Triazoles; Xanthines | 1991 |
Effects of CGS-15943A on the relaxations produced by adenosine analogs in human blood vessels.
Topics: Adenosine; Adult; Coronary Vessels; Humans; In Vitro Techniques; Mammary Arteries; Middle Aged; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Chloride; Quinazolines; Saphenous Vein; Theophylline; Triazoles | 1990 |
Differential antagonism by 1,3-dipropylxanthine-8-cyclopentylxanthine and 9-chloro-2-(2-furanyl)-5,6-dihydro-1,2,4-triazolo(1,5-c)quinazolin-5-im ine of the effects of adenosine derivatives in the presence of isoprenaline on contractile response and cycli
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cyclic AMP; Drug Interactions; Electric Stimulation; Female; Guinea Pigs; Heart; Isoproterenol; Male; Myocardial Contraction; Quinazolines; Receptors, Purinergic; Triazoles; Vasodilator Agents; Xanthines | 1990 |
Alterations in endocardial vascular resistance after reperfusion in a low flow, high demand model of ischemia: effects of dipyridamole and WEB-2086, a platelet-activating factor antagonist.
Topics: Adenosine; Animals; Azepines; Coronary Vessels; Dipyridamole; Dogs; Hemodynamics; Myocardial Reperfusion Injury; Platelet Activating Factor; Triazoles; Vascular Resistance | 1990 |
Cultured vascular smooth muscle cells from porcine coronary artery possess A1 and A2 adenosine receptor activity.
Topics: Adenosine; Adenylyl Cyclase Inhibitors; Analysis of Variance; Animals; Cells, Cultured; Coronary Vessels; Muscle, Smooth, Vascular; Phenylisopropyladenosine; Quinazolines; Receptors, Purinergic; Swine; Triazoles | 1990 |
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Antidepressive Agents; Behavior, Animal; Caffeine; Cats; Cell Membrane; Cerebral Cortex; Chemical Phenomena; Chemistry; Corpus Striatum; Male; Molecular Structure; Motor Activity; Purinergic Antagonists; Quinoxalines; Rats; Receptors, Purinergic; Sleep; Structure-Activity Relationship; Triazoles | 1990 |
Inhibition of renal vasoconstriction induced by intrarenal hypertonic saline by the nonxanthine adenosine antagonist CGS 15943A.
Topics: Adenosine; Animals; Dogs; Quinazolines; Receptors, Purinergic; Renal Circulation; Saline Solution, Hypertonic; Sodium Chloride; Theophylline; Triazoles; Vasoconstriction | 1989 |
Biochemical characterization of the triazoloquinazoline, CGS 15943, a novel, non-xanthine adenosine antagonist.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; Brain; Guinea Pigs; Kinetics; Neurotransmitter Agents; Pyrazoles; Quinazolines; Rats; Receptors, Purinergic; Triazoles; Xanthines | 1987 |
Structure-activity profile of a series of novel triazoloquinazoline adenosine antagonists.
Topics: Adenosine; Animals; Chemical Phenomena; Chemistry; Guinea Pigs; In Vitro Techniques; Molecular Conformation; Muscle, Smooth; Quinazolines; Rats; Receptors, Purinergic; Structure-Activity Relationship; Triazoles | 1988 |
Pharmacological characterization of CGS 15943A: a novel nonxanthine adenosine antagonist.
Topics: 2-Chloroadenosine; Adenosine; Animals; Blood Pressure; Coronary Vessels; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Male; Myocardial Contraction; Quinazolines; Rats; Rats, Inbred Strains; Receptors, Purinergic; Trachea; Triazoles | 1987 |
Cardiohemodynamic effect of 5-methyl-7-diethyl-amino-s-triazolo-(1,5a)pyrimidine (trapymin).
Topics: Adenosine; Amines; Aminophylline; Animals; Blood Pressure; Cardiac Output; Chemical Phenomena; Chemistry; Dogs; Dose-Response Relationship, Drug; Female; Heart Conduction System; Heart Rate; Isoproterenol; Male; Myocardium; Nitroglycerin; Norepinephrine; Oxygen Consumption; Papaverine; Papillary Muscles; Pyrimidines; Triazoles; Vasodilator Agents | 1974 |
Letter: Studies on chemical alterations of nucleic acids and their components. VIII. Alkaline rearrangement of 1-aminoadenosine to 5-amino-1-beta-d-ribofuranosyl-4-(1,2,4-triazol-3-yl)imidazole.
Topics: Adenosine; Imidazoles; Ribonucleosides; Spectrophotometry, Ultraviolet; Triazoles | 1974 |
Nature of side-reactions in oligonucleotide synthesis involving arenesulphonyl derivatives of 3-nitro-1,2,4-triazole and related condensing agents.
Topics: Adenosine; Cytidine; Deoxyguanosine; Indicators and Reagents; Magnetic Resonance Spectroscopy; Methods; Oligonucleotides; Structure-Activity Relationship; Sulfones; Thymidine; Triazoles | 1980 |
The A1 agonist CCPA reduced bisoxonol-monitored membrane potential depolarization elicited by high K+ in cerebrocortical nerve endings.
Topics: Adenosine; Animals; Cerebral Cortex; Fluorescent Dyes; Male; Membrane Potentials; Nerve Endings; Phenethylamines; Potassium; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Wistar; Synaptosomes; Thiobarbiturates; Triazoles; Veratridine; Xanthines | 1995 |
Attenuation of hypoxia-induced increases in ventilation by adenosine antagonists in rhesus monkeys.
Topics: Adenosine; Animals; Hypoxia; Macaca mulatta; Male; Phosphodiesterase Inhibitors; Pyrrolidinones; Quinazolines; Respiration; Rolipram; Triazoles | 1995 |
Effects of a non-xanthine adenosine antagonist, CGS 15943, and a phosphodiesterase inhibitor, Ro 20-1724, in a light/dark test in mice.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Animals; Anxiety; Darkness; Light; Male; Mice; Mice, Inbred ICR; Motor Activity; Phosphodiesterase Inhibitors; Quinazolines; Triazoles | 1994 |
Inhibitory effect of adenosine on electrical activity of frog melanotrophs mediated through A1 purinergic receptors.
Topics: Action Potentials; Adenosine; alpha-MSH; Animals; Cells, Cultured; Electrophysiology; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Male; Membrane Potentials; Patch-Clamp Techniques; Pertussis Toxin; Phenylisopropyladenosine; Pituitary Gland; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Quinazolines; Rana ridibunda; Tachyphylaxis; Theophylline; Triazoles; Virulence Factors, Bordetella | 1994 |
Further investigations into adenosine A1 receptor-mediated contraction in rat colonic muscularis mucosae and its augmentation by certain alkylxanthine antagonists.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Colon; Cyclooxygenase Inhibitors; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Muscle Contraction; Muscle, Smooth; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Theophylline; Triazoles; Vasodilator Agents; Xanthines | 1995 |
Adenosine and PAF dependent mechanisms lead to myocardial reperfusion injury by neutrophils after brief ischaemia.
Topics: Adenosine; Animals; Azepines; Guinea Pigs; Heart; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Neutrophil Activation; Neutrophils; Perfusion; Platelet Activating Factor; Receptors, Purinergic P1; Theobromine; Triazoles; Xanthines | 1995 |
Adenosine A1 and A2 receptor agonists alter cardiac functions and prostacyclin release in the isolated guinea-pig heart.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine; Animals; Antihypertensive Agents; Cardiac Pacing, Artificial; Cells, Cultured; Coronary Circulation; Dose-Response Relationship, Drug; Endothelium, Vascular; Epoprostenol; Guinea Pigs; Heart; Heart Rate; Male; Myocardium; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Triazoles; Vasodilation; Ventricular Function, Left; Xanthines | 1994 |
Failure of CGS15943A to block the hypotensive action of agonists acting at the adenosine A3 receptor.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blood Pressure; Female; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Wistar; Triazoles | 1994 |
Pharmacological characterization of A2-adenosine receptors in guinea-pig ventricular cardiomyocytes.
Topics: Adenosine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Cells, Cultured; Cyclic AMP; Drug Interactions; Female; Guinea Pigs; Heart Ventricles; Isoproterenol; Male; Myocardial Contraction; Myocardium; Papillary Muscles; Pertussis Toxin; Phenethylamines; Quinazolines; Receptors, Adrenergic, beta; Receptors, Purinergic P1; Signal Transduction; Triazoles; Virulence Factors, Bordetella; Xanthines | 1994 |
Effects of the new A2 adenosine receptor antagonist 8FB-PTP, an 8 substituted pyrazolo-triazolo-pyrimidine, on in vitro functional models.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cattle; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Phosphoric Diester Hydrolases; Platelet Aggregation; Purinergic P1 Receptor Antagonists; Pyrimidines; Quinazolines; Rabbits; Rats; Rats, Sprague-Dawley; Triazoles; Vasodilator Agents; Xanthines | 1994 |
Suppression of lipopolysaccharide-stimulated release of tumor necrosis factor by adenosine: evidence for A2 receptors on rat Kupffer cells.
Topics: Adenosine; Alprostadil; Animals; Bucladesine; Cells, Cultured; Cyclic AMP; Kupffer Cells; Lipopolysaccharides; Nisoldipine; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Triazoles; Tumor Necrosis Factor-alpha; Xanthines | 1994 |
Correlation of frameshift mutagenicity with DNA intercalation by CGS 20928A using an in vitro DNA unwinding assay.
Topics: Adenosine; DNA, Bacterial; DNA, Circular; Dose-Response Relationship, Drug; Frameshift Mutation; Furans; In Vitro Techniques; Intercalating Agents; Molecular Structure; Mutagens; Nucleic Acid Conformation; Plasmids; Triazoles | 1993 |
Myocardial adenosine stimulates release of cyclic adenosine monophosphate from capillary endothelial cells in guinea pig heart.
Topics: Adenosine; Adenosine Deaminase; Adenosine Triphosphate; Alprostadil; Animals; Capillaries; Coronary Vessels; Cyclic AMP; Endothelium, Vascular; Guinea Pigs; Myocardium; Oxygen; Procaterol; Quinazolines; Theophylline; Triazoles; Vasodilation | 1993 |
Functional characterization of adenosine A2 receptors in Jurkat cells and PC12 cells using adenosine receptor agonists.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Colforsin; Cyclic AMP; DNA; Humans; Isotope Labeling; Lethal Dose 50; Leukemia, T-Cell; Molecular Sequence Data; PC12 Cells; Phenethylamines; Polymerase Chain Reaction; Purinergic P1 Receptor Agonists; Quinazolines; Rats; Receptors, Purinergic P1; RNA, Messenger; Triazoles; Tumor Cells, Cultured | 1996 |
Binding of the radioligand [3H]-SCH 58261, a new non-xanthine A2A adenosine receptor antagonist, to rat striatal membranes.
Topics: Adenosine; Animals; Binding, Competitive; Corpus Striatum; In Vitro Techniques; Kinetics; Male; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Quinazolines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Triazoles; Tritium | 1996 |
Myocardial adenosine A1 and A2 receptor activities during juvenile and adult stages of development.
Topics: Adenosine; Aging; Animals; Coronary Vessels; Drug Synergism; Heart; Isoproterenol; Male; Myocardial Contraction; Myocardium; Osmolar Concentration; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Triazoles; Veins; Xanthines | 1996 |
In vivo characterisation of ZM 241385, a selective adenosine A2A receptor antagonist.
Topics: Adenosine; Animals; Cardiovascular Agents; Decerebrate State; Dogs; Female; Heart Rate; Hindlimb; In Vitro Techniques; Myocardial Contraction; Purinergic P1 Receptor Antagonists; Rats; Rats, Inbred SHR; Regional Blood Flow; Triazines; Triazoles; Vasodilation | 1996 |
Activation of multiple sites by adenosine analogues in the rat isolated aorta.
Topics: Adenosine; Animals; Aorta, Thoracic; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Rats; Rats, Wistar; Receptors, Purinergic P1; Sulfonamides; Theophylline; Triazines; Triazoles; Xanthines | 1996 |
Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype.
Topics: Adenosine; Affinity Labels; Animals; Binding Sites; Binding, Competitive; Cell Line; Cerebral Cortex; Corpus Striatum; Humans; Magnetic Resonance Spectroscopy; Quinazolines; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Substrate Specificity; Triazoles | 1996 |
Synergistic inhibition of thrombin-induced platelet aggregation by the novel nitric oxide-donor GEA 3175 and adenosine.
Topics: Adenosine; Dose-Response Relationship, Drug; Drug Synergism; Humans; Nitric Oxide; Platelet Aggregation; Thrombin; Triazoles | 1996 |
Augmented release of serotonin by adenosine A2a receptor activation and desensitization by CGS 21680 in the rat nucleus tractus solitarius.
Topics: Adenosine; Animals; In Vitro Techniques; Kinetics; Male; Phenethylamines; Purinergic P1 Receptor Agonists; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Serotonin; Solitary Nucleus; Triazoles; Xanthines | 1996 |
The selective adenosine A2A receptor antagonist SCH 58261 discriminates between two different binding sites for [3H]-CGS 21680 in the rat brain.
Topics: Adenosine; Animals; Autoradiography; Binding, Competitive; Brain; Cerebral Cortex; Corpus Striatum; Hippocampus; Phenethylamines; Protein Binding; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Triazoles; Tritium | 1996 |
Repeated treatment with adenosine A1 receptor agonist and antagonist modifies the anticonvulsant properties of CPPene.
Topics: Acoustic Stimulation; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Anticonvulsants; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Injections, Intraventricular; Male; Mice; Mice, Inbred DBA; Piperazines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Triazoles; Xanthines | 1996 |
The role of the A(2A) adenosine receptor subtype in functional hyperaemia in the hindlimb of anaesthetized cats.
Topics: Adenosine; Animals; Arteries; Cats; Gases; Hindlimb; Hydrogen-Ion Concentration; Hyperemia; Isometric Contraction; Male; Muscles; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Regional Blood Flow; Theophylline; Triazines; Triazoles | 1996 |
Adenosine stimulation of DNA synthesis in human endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Triphosphate; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA; Endothelium, Vascular; Humans; Kinetics; Poly A; Purinergic P1 Receptor Antagonists; Quinazolines; Tetradecanoylphorbol Acetate; Thioinosine; Thionucleotides; Thymidine; Triazoles; Umbilical Veins | 1997 |
Adenosine analogues relax guinea-pig taenia caeci via an adenosine A2B receptor and a xanthine-resistant site.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cecum; Dose-Response Relationship, Drug; Guinea Pigs; Male; Muscle Relaxation; Muscle, Smooth; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Theophylline; Triazines; Triazoles; Vasodilator Agents; Xanthines | 1997 |
Adenosine A3 receptor agonists protect HL-60 and U-937 cells from apoptosis induced by A3 antagonists.
Topics: Adenosine; Apoptosis; Dihydropyridines; DNA Fragmentation; Dose-Response Relationship, Drug; HL-60 Cells; Humans; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrazoles; Quinazolines; Triazoles | 1997 |
Adenosine A3 receptors promote degranulation of rat mast cells both in vitro and in vivo.
Topics: Adenosine; Administration, Cutaneous; Animals; Blood Proteins; Cell Degranulation; Cyproheptadine; Dinitrophenols; Female; Humans; In Vitro Techniques; Injections, Intravenous; Male; Mast Cells; Mice; p-Methoxy-N-methylphenethylamine; Pleura; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Wistar; Receptors, Purinergic P1; Serotonin; Serotonin Antagonists; Serum Albumin; Skin; Theophylline; Triazoles; Xanthines | 1997 |
Desensitisation of the adenosine A1 receptor by the A2A receptor in the rat striatum.
Topics: Adenosine; Animals; Antihypertensive Agents; Corpus Striatum; Enzyme Inhibitors; Isoquinolines; Phenethylamines; Presynaptic Terminals; Protein Kinase C; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Sensitivity and Specificity; Sulfonamides; Synaptosomes; Triazines; Triazoles; Tritium; Xanthines | 1997 |
Adenosine A2A receptor agonists increase Fos-like immunoreactivity in mesolimbic areas.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Dopamine Agonists; Immunohistochemistry; Limbic System; Male; Oxidopamine; Phenethylamines; Proto-Oncogene Proteins c-fos; Purinergic Antagonists; Purinergic P1 Receptor Agonists; Pyrimidines; Quinpirole; Rats; Rats, Sprague-Dawley; Triazoles | 1997 |
Memory of extracellular adenosine A2A purinergic receptor-mediated signaling in murine T cells.
Topics: Adenosine; Animals; Cell Division; Exocytosis; Extracellular Matrix; Fas Ligand Protein; fas Receptor; Interleukin-2; Membrane Glycoproteins; Mice; Mice, Inbred DBA; Phenethylamines; Purinergic P1 Receptor Agonists; Receptor, Adenosine A2A; Receptors, Antigen, T-Cell; Receptors, Purinergic P1; Signal Transduction; T-Lymphocytes; Triazines; Triazoles | 1997 |
An endogenous A2B adenosine receptor coupled to cyclic AMP generation in human embryonic kidney (HEK 293) cells.
Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Cells, Cultured; Cyclic AMP; DNA, Complementary; Gene Amplification; Humans; In Vitro Techniques; Kidney; Phenethylamines; Polymerase Chain Reaction; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A2B; Receptors, Purinergic P1; Triazoles | 1997 |
ZM241385 is an antagonist of the facilitatory responses produced by the A2A adenosine receptor agonists CGS21680 and HENECA in the rat hippocampus.
Topics: Acetylcholine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Antihypertensive Agents; Binding Sites; Hippocampus; Ligands; Membranes; Phenethylamines; Platelet Aggregation Inhibitors; Purinergic P1 Receptor Agonists; Rats; Synaptic Transmission; Synaptosomes; Triazines; Triazoles; Visual Cortex | 1997 |
Activation of two sites by adenosine receptor agonists to cause relaxation in rat isolated mesenteric artery.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Anti-Arrhythmia Agents; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Male; Mesenteric Arteries; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Vasodilation; Vasodilator Agents | 1997 |
Inhibitory effect of adenosine on degranulation of human cultured mast cells upon cross-linking of Fc epsilon RI.
Topics: Adenosine; Antibodies; Chymases; Cross-Linking Reagents; Cyclic AMP; Guanosine; Humans; Immunoglobulin E; Mast Cells; Mitogen-Activated Protein Kinase 1; Phenethylamines; Phosphorylation; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, IgE; RNA, Messenger; Serine Endopeptidases; Thioinosine; Thionucleosides; Triazines; Triazoles; Tryptases | 1998 |
[3H]SCH 58261, a selective adenosine A2A receptor antagonist, is a useful ligand in autoradiographic studies.
Topics: Adenosine; Animals; Antihypertensive Agents; Autoradiography; Binding, Competitive; GTP-Binding Proteins; Guanosine Triphosphate; Ligands; Magnesium; Male; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Triazoles; Tritium | 1998 |
Adenosine modulates hypoxia-induced responses in rat PC12 cells via the A2A receptor.
Topics: Adenosine; Adenosine Deaminase; Adrenal Gland Neoplasms; Animals; Calcium; Cell Hypoxia; Fluorescent Dyes; Fura-2; Lung; Membrane Potentials; Patch-Clamp Techniques; PC12 Cells; Pheochromocytoma; Purinergic P1 Receptor Antagonists; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptor, Adenosine A3; Receptors, Purinergic P1; RNA, Messenger; Theophylline; Transcription, Genetic; Triazines; Triazoles | 1998 |
The A2A adenosine receptor mediates coronary vasodilation.
Topics: Adenosine; Animals; Coronary Vessels; Female; Guinea Pigs; Male; Perfusion; Phenethylamines; Piperazines; Pyrimidines; Receptors, Purinergic P1; Triazoles; Tubercidin; Vasodilation; Xanthines | 1998 |
Novel 3-aralkyl-7-(amino-substituted)-1,2,3-triazolo[4,5-d]pyrimidines with high affinity toward A1 adenosine receptors.
Topics: Adenosine; Animals; Brain; Cattle; Cell Membrane; Cerebral Cortex; Corpus Striatum; Phenethylamines; Pyridazines; Pyrimidines; Radioligand Assay; Receptor, Adenosine A2A; Receptors, Purinergic P1; Stereoisomerism; Structure-Activity Relationship; Triazoles | 1998 |
Pharmacological characterization of adenosine A2B receptors: studies in human mast cells co-expressing A2A and A2B adenosine receptor subtypes.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Calcium; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Mast Cells; Phenethylamines; Pyrimidines; Receptors, Purinergic P1; Triazoles; Tumor Cells, Cultured | 1998 |
Role of adenosine and its receptors in the vasodilatation induced in the cerebral cortex of the rat by systemic hypoxia.
Topics: Adenosine; Animals; Blood Flow Velocity; Blood-Brain Barrier; Erythrocytes; Hypoxia; Laser-Doppler Flowmetry; Male; Parietal Lobe; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Vasodilation | 1998 |
Protection against kainate-induced excitotoxicity by adenosine A2A receptor agonists and antagonists.
Topics: Adenosine; Animals; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Neurons; Neuroprotective Agents; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Triazines; Triazoles; Xanthines | 1998 |
Protection against hippocampal kainate excitotoxicity by intracerebral administration of an adenosine A2A receptor antagonist.
Topics: Adenosine; Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Brain Chemistry; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Neurotoxins; Phenethylamines; Rats; Rats, Wistar; Triazines; Triazoles | 1998 |
Binding affinity of adenosine receptor agonists and antagonists at human cloned A3 adenosine receptors.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Binding, Competitive; Cell Line; Cloning, Molecular; Humans; Kidney; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Quinazolines; Receptor, Adenosine A3; Receptors, Purinergic P1; Transfection; Triazines; Triazoles | 1998 |
A2A-adenosine receptor reserve for coronary vasodilation.
Topics: Adenosine; Animals; Coronary Circulation; Female; Guinea Pigs; Heart; In Vitro Techniques; Kinetics; Male; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Triazines; Triazoles; Vasodilation | 1998 |
The role of adenosine in rat coronary flow regulation during respiratory and metabolic acidosis.
Topics: Acidosis; Acidosis, Respiratory; Adenosine; Animals; Caffeine; Coronary Circulation; Hypercapnia; Male; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Theophylline; Triazines; Triazoles | 1998 |
Adenosine receptor subtypes and vasodilatation in rat skeletal muscle during systemic hypoxia: a role for A1 receptors.
Topics: Adenosine; Animals; Antihypertensive Agents; Blood Gas Analysis; Hydrogen-Ion Concentration; Hypoxia; Male; Muscle, Skeletal; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Regional Blood Flow; Respiration; Triazines; Triazoles; Vasodilation; Vasodilator Agents; Xanthines | 1999 |
Interaction between adenosine A1 and A2 receptor-mediated responses in the rat hippocampus in vitro.
Topics: Adenosine; Animals; Excitatory Postsynaptic Potentials; Hippocampus; Male; Organ Culture Techniques; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrazines; Rats; Rats, Wistar; Receptors, Purinergic P1; Triazines; Triazoles | 1998 |
Adenosine A2a receptors increase arterial endothelial cell nitric oxide.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Carotid Arteries; Cells, Cultured; Endothelium, Vascular; Humans; Iliac Artery; Nitric Oxide; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Swine; Triazines; Triazoles; Xanthines | 1998 |
Differences in the order of potency for agonists but not antagonists at human and rat adenosine A2A receptors.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; CHO Cells; Cloning, Molecular; Cricetinae; Cyclic AMP; Humans; Kinetics; PC12 Cells; Phenethylamines; Polymerase Chain Reaction; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Radioligand Assay; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptors, Purinergic P1; Recombinant Proteins; RNA, Messenger; Transcription, Genetic; Transfection; Triazoles; Tritium | 1999 |
Adenosine A1 receptor-mediated antiadrenergic effects are modulated by A2a receptor activation in rat heart.
Topics: Adenosine; Adrenergic alpha-Antagonists; Animals; Calcium; Drug Synergism; Heart; In Vitro Techniques; Intracellular Membranes; Male; Myocardium; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Triazines; Triazoles | 1999 |
Sensitization by chronic diazepam treatment of A2A adenosine receptor-mediated relaxation in rat pulmonary artery.
Topics: Adenosine; Animals; Carrier Proteins; Diazepam; Dinucleoside Phosphates; Dipyridamole; Dose-Response Relationship, Drug; Female; Heart; Heart Atria; Muscle Relaxation; Phenethylamines; Pulmonary Artery; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Thioinosine; Triazines; Triazoles; Verapamil | 1999 |
Opposite tonic modulation of dopamine and adenosine on c-fos gene expression in striatopallidal neurons.
Topics: Adenosine; Animals; Antiparkinson Agents; Corpus Striatum; Dopamine; Dopamine Agonists; Drug Design; Gene Expression Regulation; Genes, fos; Globus Pallidus; In Situ Hybridization; Male; Models, Neurological; Nerve Tissue Proteins; Neurons; Oxidopamine; Proto-Oncogene Proteins c-fos; Purinergic P1 Receptor Antagonists; Pyrimidines; Quinolines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Dopamine D2; RNA, Messenger; Triazoles; Tyrosine 3-Monooxygenase | 1999 |
G protein coupling of CGS 21680 binding sites in the rat hippocampus and cortex is different from that of adenosine A1 and striatal A2A receptors.
Topics: Adenosine; Animals; Binding Sites; Binding, Competitive; Brain; Cerebral Cortex; Cholera Toxin; Corpus Striatum; Ethylmaleimide; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Hippocampus; Male; Membranes; Pertussis Toxin; Phenethylamines; Purinergic P1 Receptor Agonists; Pyrimidines; Rats; Rats, Wistar; Receptors, Purinergic P1; Triazines; Triazoles; Tritium; Virulence Factors, Bordetella | 1999 |
Species-dependent hemodynamic effects of adenosine A3-receptor agonists IB-MECA and Cl-IB-MECA.
Topics: Adenosine; Animals; Coronary Circulation; Coronary Vessels; Dihydropyridines; Female; Hemodynamics; In Vitro Techniques; Male; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Rabbits; Rats; Rats, Sprague-Dawley; Species Specificity; Swine; Triazoles; Vasodilation | 1999 |
Brief myocardial ischemia attenuates platelet thrombosis in remote, damaged, and stenotic carotid arteries.
Topics: Adenosine; Animals; Blood Platelets; Carotid Artery Thrombosis; Carotid Stenosis; Dogs; Myocardial Ischemia; Quinazolines; Rabbits; Receptors, Purinergic P1; Triazoles; Vascular Patency | 1999 |
Increase in the number, G protein coupling, and efficiency of facilitatory adenosine A2A receptors in the limbic cortex, but not striatum, of aged rats.
Topics: Adenosine; Aging; Animals; Cell Membrane; Cerebral Cortex; Corpus Striatum; Cyclic AMP; Dentate Gyrus; GTP-Binding Proteins; Kinetics; Limbic System; Male; Organ Specificity; Phenethylamines; Purinergic P1 Receptor Agonists; Radioligand Assay; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Triazines; Triazoles; Tritium | 1999 |
Autoradiographic comparison of the potency of several structurally unrelated adenosine receptor antagonists at adenosine A1 and A(2A) receptors.
Topics: Adenosine; Animals; Autoradiography; Binding, Competitive; Brain; Caffeine; In Vitro Techniques; Male; Phenethylamines; Purinergic P1 Receptor Antagonists; Pyrazines; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Tritium; Xanthines | 1999 |
Neutrophil A2A adenosine receptor inhibits inflammation in a rat model of meningitis: synergy with the type IV phosphodiesterase inhibitor, rolipram.
Topics: Adenosine; Animals; Blood-Brain Barrier; Cell Adhesion; Cyclic AMP; Disease Models, Animal; Drug Synergism; Humans; Leukocytosis; Meningitis, Bacterial; Neutrophil Activation; Neutrophils; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Respiratory Burst; Rolipram; Superoxides; Triazines; Triazoles; Tumor Necrosis Factor-alpha | 1999 |
Adenosine and memory storage: effect of A(1) and A(2) receptor antagonists.
Topics: Adenosine; Animals; Avoidance Learning; Caffeine; Central Nervous System Stimulants; Male; Memory; Mice; Purinergic P1 Receptor Antagonists; Pyrimidines; Triazoles; Xanthines | 1999 |
The anticonvulsant BW534U87 depresses epileptiform activity in rat hippocampal slices by an adenosine-dependent mechanism and through inhibition of voltage-gated Na+ channels.
Topics: Action Potentials; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Anticonvulsants; Brain Chemistry; CHO Cells; Cricetinae; Electrophysiology; Enzyme Inhibitors; Epilepsy; Female; Hippocampus; In Vitro Techniques; Ion Channel Gating; Magnesium; Male; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sodium Channels; Triazoles | 1999 |
Effect of A2A adenosine receptor stimulation and antagonism on synaptic depression induced by in vitro ischaemia in rat hippocampal slices.
Topics: Adenosine; Animals; Excitatory Postsynaptic Potentials; Hippocampus; Hypoxia-Ischemia, Brain; In Vitro Techniques; Male; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Synapses; Synaptic Transmission; Triazines; Triazoles; Xanthines | 1999 |
Adenosine inhibits a non-inactivating K+ current in bovine adrenal cortical cells by activation of multiple P1 receptors.
Topics: Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Cattle; GTP-Binding Proteins; In Vitro Techniques; Male; Membrane Potentials; Patch-Clamp Techniques; Potassium; Potassium Channel Blockers; Potassium Channels; Receptors, Purinergic P1; Signal Transduction; Triazines; Triazoles; Xanthines; Zona Fasciculata | 1999 |
Sensitization of visceral afferents to bradykinin in rat jejunum in vitro.
Topics: Adenosine; Animals; Bradykinin; Bucladesine; Cyclooxygenase Inhibitors; Dinoprostone; Histamine; Histamine Antagonists; Histamine H2 Antagonists; In Vitro Techniques; Jejunum; Male; Membrane Potentials; Naproxen; Neurons, Afferent; Piperidines; Ranitidine; Rats; Rats, Inbred Strains; Serotonin; Stimulation, Chemical; Triazines; Triazoles; Xanthines | 1999 |
Increase in the vasorelaxant potency of K(ATP) channel opening drugs by adenosine A(1) and A(2) receptors in the pig coronary artery.
Topics: Adenosine; Animals; ATP-Binding Cassette Transporters; Coronary Vessels; Cromakalim; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; KATP Channels; Nicorandil; Phenethylamines; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Swine; Triazines; Triazoles; Vasodilator Agents; Xanthines | 1999 |
Afferent arteriolar adenosine A2a receptors are coupled to KATP in in vitro perfused hydronephrotic rat kidney.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Arterioles; Blood Pressure; Enzyme Inhibitors; Hydronephrosis; Kidney; Perfusion; Potassium Channels; Potassium Chloride; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Renal Artery; Renal Circulation; Triazines; Triazoles; Vasoconstriction; Vasodilation; Vasodilator Agents; Xanthines | 1999 |
Cross talk between A(1) and A(2A) adenosine receptors in the hippocampus and cortex of young adult and old rats.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Aging; Animals; Binding, Competitive; Cerebral Cortex; Electrophysiology; Hippocampus; In Vitro Techniques; Male; Phenethylamines; Protein Kinase C; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor Cross-Talk; Receptor, Adenosine A2A; Receptors, Purinergic P1; Synaptic Membranes; Triazines; Triazoles; Xanthines | 1999 |
Adenosine receptor occupancy suppresses chemoattractant-induced phospholipase D activity by diminishing membrane recruitment of small GTPases.
Topics: Adenosine; Adenosine Deaminase; Adenosine-5'-(N-ethylcarboxamide); ADP-Ribosylation Factor 1; Adult; Caffeine; Cell Membrane; Enzyme Activation; GTP Phosphohydrolases; Humans; In Vitro Techniques; Isoenzymes; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phenethylamines; Phospholipase D; Protein Kinase C; Protein Kinase C-alpha; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A2A; Receptors, Purinergic P1; rhoA GTP-Binding Protein; Triazoles | 2000 |
[Adenosine reduces ischemia/reperfusion-induced liver injury by inhibiting leukocyte activation].
Topics: Adenosine; Alkynes; Animals; Humans; In Vitro Techniques; Leukocyte Elastase; Liver; Male; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Rats; Rats, Wistar; Receptors, Purinergic P1; Reperfusion Injury; Transaminases; Triazines; Triazoles; Tumor Necrosis Factor-alpha | 1999 |
Localization and action of adenosine A2a receptors in regions of the brainstem important in cardiovascular control.
Topics: Adenosine; Animals; Aorta; Autoradiography; Blood Pressure; Brain Stem; Image Processing, Computer-Assisted; Iodine Radioisotopes; Phrenic Nerve; Pressoreceptors; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Reflex; Stimulation, Chemical; Triazines; Triazoles | 2000 |
The anxiogenic-like effect of caffeine in two experimental procedures measuring anxiety in the mouse is not shared by selective A(2A) adenosine receptor antagonists.
Topics: Adenosine; Administration, Oral; Animals; Anxiety; Behavior, Animal; Caffeine; Darkness; Drug Administration Schedule; Injections, Intraperitoneal; Light; Male; Maze Learning; Mice; Mice, Knockout; Neuroprotective Agents; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Reaction Time; Receptor, Adenosine A2A; Triazines; Triazoles; Xanthines | 2000 |
Brain adenosine receptors as targets for therapeutic intervention in neurodegenerative diseases.
Topics: Adenosine; Animals; Astrocytes; Brain Infarction; Brain Ischemia; Cell Death; Humans; Neurodegenerative Diseases; Neuroprotective Agents; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Triazoles | 1999 |
Antagonism of coronary artery relaxation by adenosine A2A-receptor antagonist ZM241385.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Antihypertensive Agents; Coronary Vessels; Dinoprost; Dose-Response Relationship, Drug; Drug Interactions; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Phenethylamines; Purinergic P1 Receptor Antagonists; Pyrimidines; Receptors, Purinergic P1; Swine; Triazines; Triazoles; Vasodilator Agents | 2000 |
Adenosine mediates nitric-oxide-independent renal vasodilation by activation of A2A receptors.
Topics: Adenosine; Animals; Endothelium, Vascular; Female; In Vitro Techniques; Male; Nitric Oxide; Phenethylamines; Potassium; Potassium Channels; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rabbits; Receptors, Purinergic; Renal Artery; Triazines; Triazoles; Vasodilation; Vasodilator Agents | 1999 |
Promotion of forskolin-induced long-term potentiation of synaptic transmission by caffeine in area CA1 of the rat hippocampus.
Topics: Adenosine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Central Nervous System Stimulants; Colforsin; Cyclic AMP; Drug Synergism; Excitatory Postsynaptic Potentials; Hippocampus; Long-Term Potentiation; Male; Quinazolines; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Triazoles; Xanthines | 1999 |
Activation of the A3 adenosine receptor affects cell cycle progression and cell growth.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Analysis of Variance; Animals; Antineoplastic Agents; Cell Cycle; Cell Line; Cell Membrane; Cell Survival; CHO Cells; Cricetinae; Dihydropyridines; Flow Cytometry; Humans; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A3; Receptors, Purinergic P1; Transfection; Triazoles | 2000 |
Tonic adenosine neuromodulation is preserved in motor nerve endings of aged rats.
Topics: Acetylcholine; Adenosine; Aging; Animals; Electric Stimulation; Male; Motor Neurons; Nerve Endings; Neurotransmitter Agents; Phrenic Nerve; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Triazines; Triazoles; Xanthines | 2000 |
[(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors.
Topics: Adenosine; Adenylyl Cyclase Inhibitors; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Phenylurea Compounds; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Receptor, Adenosine A3; Receptors, Purinergic P1; Triazoles; Tritium | 2000 |
Adenosine acts as a chemoprotective agent by stimulating G-CSF production: a role for A1 and A3 adenosine receptors.
Topics: Adenosine; Animals; Bone Marrow Cells; Cell Cycle; Cell Division; Cells, Cultured; Cyclophosphamide; Granulocyte Colony-Stimulating Factor; Humans; Leukocytes, Mononuclear; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A3; Receptors, Purinergic P1; Theobromine; Triazoles; Xanthines | 2000 |
A galpha(s) carboxyl-terminal peptide prevents G(s) activation by the A(2A) adenosine receptor.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; Cell Membrane; GTP-Binding Protein alpha Subunits, Gs; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Molecular Sequence Data; Peptides; Phenethylamines; Protein Conformation; Pyrimidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Signal Transduction; Triazoles; Tritium | 2000 |
Accelerated resequestration of cytosolic calcium and suppression of the pro-inflammatory activities of human neutrophils by CGS 21680 in vitro.
Topics: Adenosine; Calcium; Calcium Radioisotopes; Cyclic AMP; Cytosol; Dose-Response Relationship, Drug; Fura-2; Humans; Inflammation; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pancreatic Elastase; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P2 Receptor Antagonists; Superoxides; Thapsigargin; Triazines; Triazoles | 2000 |
Down-regulation of vascular endothelial growth factor expression after A(2A) adenosine receptor activation in PC12 pheochromocytoma cells.
Topics: Adenosine; Animals; Down-Regulation; Endothelial Growth Factors; Gene Expression Regulation; Lymphokines; PC12 Cells; Phenethylamines; Rats; Receptors, Purinergic P1; RNA, Messenger; Signal Transduction; Triazines; Triazoles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Adenosine A2A receptors regulate the extracellular accumulation of excitatory amino acids upon metabolic dysfunction in chick cultured retinal cells.
Topics: Adenosine; Analysis of Variance; Animals; Aspartic Acid; Bicuculline; Cells, Cultured; Chick Embryo; Chromatography, High Pressure Liquid; Excitatory Amino Acids; Extracellular Space; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycolysis; Humans; Ischemia; Organophosphorus Compounds; Purinergic P1 Receptor Antagonists; Pyrimidines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Retina; Triazines; Triazoles; Xanthines | 2000 |
Extracellular ATP reduces optically monitored electrical signals in hippocampal slices through metabolism to adenosine.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Hippocampus; Organ Culture Techniques; Rats; Rats, Wistar; Signal Transduction; Triazines; Triazoles; Uridine Diphosphate; Xanthines | 2000 |
SCH 58261 and ZM 241385 differentially prevent the motor effects of CGS 21680 in mice: evidence for a functional 'atypical' adenosine A(2A) receptor.
Topics: Adenosine; Animals; Dose-Response Relationship, Drug; Drug Interactions; Exploratory Behavior; Injections, Intraventricular; Male; Maze Learning; Mice; Mice, Knockout; Motor Activity; Neuroprotective Agents; Phenethylamines; Pyrimidines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Time Factors; Triazines; Triazoles | 2000 |
Adenosine A(2A) and A(2B) receptors in cultured human and porcine coronary artery endothelial cells.
Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Affinity Labels; Animals; Binding, Competitive; Cells, Cultured; Coronary Vessels; Cyclic AMP; Endothelium, Vascular; Gene Expression Regulation; Humans; Iodine Radioisotopes; Iodobenzenes; Kinetics; Phenethylamines; Purinergic P1 Receptor Antagonists; Radioligand Assay; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; Swine; Transcription, Genetic; Triazines; Triazoles | 2000 |
Striatal A2A adenosine receptor antagonism differentially modifies striatal glutamate outflow in vivo in young and aged rats.
Topics: Adenosine; Age Factors; Aging; Animals; Aspartic Acid; Glutamic Acid; Male; Neostriatum; Neurons; Neuroprotective Agents; Potassium; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Time Factors; Triazoles | 2000 |
Adenosine and selective A(2A) receptor agonists reduce ischemia/reperfusion injury of rat liver mainly by inhibiting leukocyte activation.
Topics: Adenosine; Alkynes; Animals; Calcium; Cells, Cultured; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Ischemia; Leukocyte Elastase; Lipopolysaccharides; Liver; Male; Monocytes; Neutrophil Activation; Peroxidase; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Reperfusion Injury; Triazines; Triazoles; Tumor Necrosis Factor-alpha | 2000 |
Adenosine A(1) and A(3) receptors mediate inhibition of synaptic transmission in rat cortical neurons.
Topics: Adenosine; Animals; Cerebral Cortex; Drug Interactions; Electric Stimulation; Female; In Vitro Techniques; Male; Neurons; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Wistar; Receptor, Adenosine A3; Receptors, Purinergic P1; Synaptic Transmission; Triazoles; Xanthines | 2001 |
Adenosine A(2A) receptors mediate cardiovascular responses to hypoxia in fetal sheep.
Topics: Adenosine; Animals; Blood Gas Analysis; Blood Pressure; Female; Fetal Hypoxia; Heart Rate; Hydrogen-Ion Concentration; Phenethylamines; Pregnancy; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2A; Receptors, Purinergic P1; Sheep; Triazines; Triazoles; Xanthines | 2001 |
Potentiation of cytokine induction of group IIA phospholipase A(2) in rat mesangial cells by ATP and adenosine via the A2A adenosine receptor.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Deaminase; Adenosine Triphosphate; Animals; Blotting, Northern; Cells, Cultured; Enzyme Induction; Enzyme Inhibitors; Glomerular Mesangium; Group II Phospholipases A2; Interleukin-1; Phospholipases A; Purinergic P2 Receptor Antagonists; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; RNA, Messenger; Signal Transduction; Suramin; Triazines; Triazoles; Uridine Triphosphate; Vasodilator Agents | 2001 |
Functional and molecular characterization of receptor subtypes mediating coronary microvascular dilation to adenosine.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Animals; Antihypertensive Agents; Blotting, Western; Colforsin; Coronary Vessels; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Glyburide; Heart; Hypoglycemic Agents; In Situ Hybridization; Male; Microcirculation; Myocardium; Peptides; Phenethylamines; Potassium Channel Blockers; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; Stress, Physiological; Swine; Thionucleotides; Tissue Distribution; Triazines; Triazoles | 2001 |
Cyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A(2A) receptor agonists.
Topics: Adenosine; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Humans; Neutrophils; Receptor, Adenosine A2A; Receptors, Purinergic P1; Respiratory Burst; Triazines; Triazoles | 2001 |
Adenosine modulates cell growth in baby hamster kidney (BHK) cells.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adenosine Kinase; Animals; Cell Division; Cell Line; Cricetinae; Enzyme Inhibitors; Kidney; Mutation; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A3; Receptors, Purinergic P1; Triazoles | 2000 |
Receptor subtypes mediating adenosine-induced dilation of cerebral arterioles.
Topics: Adenosine; Adenosine Triphosphate; Animals; Antihypertensive Agents; Arterioles; Cerebrovascular Circulation; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Phenethylamines; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Triazines; Triazoles; Vasodilation | 2001 |
Adenosine A(1) and A(2A) receptors modulate sleep state and breathing in fetal sheep.
Topics: Adenosine; Animals; Fetus; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Respiratory Physiological Phenomena; Sheep; Sleep Stages; Triazines; Triazoles; Xanthines | 2001 |
Novel short-acting A2A adenosine receptor agonists for coronary vasodilation: inverse relationship between affinity and duration of action of A2A agonists.
Topics: Adenosine; Animals; Antihypertensive Agents; Coronary Vessels; Corpus Striatum; Cyclic AMP; Dose-Response Relationship, Drug; Female; Humans; Male; PC12 Cells; Phenethylamines; Purinergic P1 Receptor Agonists; Purines; Pyrazoles; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Swine; Triazines; Triazoles; Vasodilation; Vasodilator Agents | 2001 |
Guanosine-induced increase in free cytosolic calcium concentration in mouse astrocytes in primary cultures: does it act on an A3 adenosine receptor?
Topics: Adenosine; Animals; Astrocytes; Brain; Calcium; Cells, Cultured; Cytosol; Dose-Response Relationship, Drug; Extracellular Space; Guanosine; Mice; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A3; Receptors, Purinergic P1; Theophylline; Triazoles; Xanthines | 2001 |
Adenosine-mediated inhibition of striatal GABAergic synaptic transmission during in vitro ischaemia.
Topics: Adenosine; Adenosine Triphosphate; Animals; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid; Male; Membrane Potentials; Neural Inhibition; Organ Culture Techniques; Patch-Clamp Techniques; Potassium Channels; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Synaptic Transmission; Triazines; Triazoles; Xanthines | 2001 |
Suppression of presynaptic responses to adenosine by activation of NMDA receptors.
Topics: Action Potentials; Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Baclofen; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; GABA Agonists; Glycine; Hippocampus; In Vitro Techniques; Kainic Acid; Long-Term Potentiation; Male; N-Methylaspartate; Phenethylamines; Presynaptic Terminals; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, N-Methyl-D-Aspartate; Time Factors; Triazines; Triazoles | 2001 |
Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia.
Topics: Adenosine; Animals; Caffeine; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Female; Male; Mesocricetus; Muscle Contraction; Mutation; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Theobromine; Theophylline; Triazines; Triazoles; Xanthines | 2001 |
Adenosine A(2A) and A(2B) receptor activation of erythropoietin production.
Topics: Adenosine; Alkaloids; Benzophenanthridines; Carcinoma, Hepatocellular; Enzyme Activation; Erythropoietin; Humans; Liver Neoplasms; Phenanthridines; Phenethylamines; Protein Kinase C; Purinergic P1 Receptor Antagonists; Pyrimidines; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptors, Purinergic P1; RNA, Messenger; Triazoles; Tumor Cells, Cultured; Xanthines | 2001 |
Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blood Pressure; Diphenhydramine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Heart Rate; Hypotension; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Vasodilator Agents; Xanthines | 2001 |
Role of adenosine and P2 receptors in the penile tumescence in anesthetized dogs.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Anesthesia; Animals; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Injections, Intravenous; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Penile Erection; Penis; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Theophylline; Thionucleotides; Triazines; Triazoles | 2001 |
Oxygen delivery and oxygen consumption in rat hindlimb during systemic hypoxia: role of adenosine.
Topics: Adenosine; Animals; Hemodynamics; Hindlimb; Hypoxia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Oxygen Consumption; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Triazines; Triazoles; Vital Capacity; Xanthines | 2001 |
Regulation of K(+) current in human airway epithelial cells by exogenous and autocrine adenosine.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine; Affinity Labels; Amiloride; Autocrine Communication; Cell Line; Cell Polarity; Clotrimazole; Diuretics; Epithelial Cells; Equilibrative Nucleoside Transporter 1; Equilibrative-Nucleoside Transporter 2; Growth Inhibitors; Humans; Membrane Transport Proteins; Patch-Clamp Techniques; Potassium; Potassium Channels; Quinazolines; Receptors, Purinergic P1; Respiratory Mucosa; Theobromine; Thioinosine; Triazoles; Uridine; Xanthines | 2001 |
In vivo labelling of the adenosine A2A receptor in mouse brain using the selective antagonist [3H]SCH 58261.
Topics: Adenosine; Animals; Binding Sites; Binding, Competitive; Blood-Brain Barrier; Brain; Caffeine; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Mice, Knockout; Neurons; Neuroprotective Agents; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Pyrimidines; Radioligand Assay; Receptor, Adenosine A2A; Receptors, Purinergic P1; Triazoles; Tritium | 2001 |
Solubilisation and immunoprecipitation of rat striatal adenosine A(2A) receptors.
Topics: Adenosine; Animals; Cholic Acids; Corpus Striatum; Detergents; Phenethylamines; Precipitin Tests; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Radioligand Assay; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Solubility; Triazines; Triazoles | 2001 |
Adenosine inhibits excitatory transmission to substantia gelatinosa neurons of the adult rat spinal cord through the activation of presynaptic A(1) adenosine receptor.
Topics: Adenosine; Age Factors; Analgesics; Animals; Antihypertensive Agents; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Neural Inhibition; Neurons; Patch-Clamp Techniques; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Substantia Gelatinosa; Triazines; Triazoles; Xanthines | 2001 |
Effects of A(3) adenosine receptor activation and gene knock-out in ischemic-reperfused mouse heart.
Topics: Adenosine; Amino Acids; Animals; Creatine; Heart Rate; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Perfusion; Phenethylamines; Pipecolic Acids; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A3; Receptors, Purinergic P1; Triazoles; Xanthines | 2002 |
Hippocampal injury and neurobehavioral deficits following hyperglycemic cerebral ischemia: effect of theophylline and ZM 241385.
Topics: Adenosine; Animals; Blood Glucose; Cell Death; Cerebral Infarction; Escape Reaction; Hippocampus; Injections, Intraperitoneal; Male; Maze Learning; Neurons; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles | 2002 |
A(3) adenosine receptors in human neutrophils and promyelocytic HL60 cells: a pharmacological and biochemical study.
Topics: Adenosine; Binding, Competitive; Biological Transport; Calcium; Cyclic AMP; Gene Expression; Granulocytes; HL-60 Cells; Humans; Neutrophils; Phenylurea Compounds; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A3; Receptors, Purinergic P1; Superoxides; Triazoles | 2002 |
Binding thermodynamics at the human A(3) adenosine receptor.
Topics: Adenosine; Animals; Cells, Cultured; CHO Cells; Cricetinae; Humans; Kinetics; Phenylurea Compounds; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A3; Receptors, Purinergic P1; Thermodynamics; Transfection; Triazoles | 2002 |
Effects of CGS 21680, a selective adenosine A2A receptor agonist, on allergic airways inflammation in the rat.
Topics: Adenosine; Allergens; Animals; Anti-Inflammatory Agents; Asthma; Blood Pressure; Budesonide; Dose-Response Relationship, Drug; Inflammation; Lung; Male; Ovalbumin; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Rats, Inbred BN; Receptor, Adenosine A2A; Triazines; Triazoles; Vascular Resistance | 2002 |
Targeted deletion of adenosine A(3) receptors augments adenosine-induced coronary flow in isolated mouse heart.
Topics: Adenosine; Animals; Coronary Circulation; Coronary Vessels; Gene Deletion; Heart Rate; Mice; Mice, Knockout; Phenethylamines; Quinazolines; Receptor, Adenosine A3; Receptors, Purinergic P1; Triazoles; Vasodilation; Ventricular Pressure | 2002 |
Vasodilator responses to adenosine and hyperemia are mediated by A(1) and A(2) receptors in the cat vascular bed.
Topics: Adenosine; Adenosine Triphosphate; Animals; Cats; Dose-Response Relationship, Drug; Female; Hemodynamics; Hindlimb; Hyperemia; Male; Perfusion; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Receptors, Purinergic P1; Triazoles; Vascular Resistance; Vasodilation; Xanthines | 2002 |
Effects of adenosine A1 and A2A receptor activation on the evoked release of glutamate from rat cerebrocortical synaptosomes.
Topics: Adenosine; Analysis of Variance; Animals; Cerebral Cortex; Chromatography, High Pressure Liquid; Glutamic Acid; In Vitro Techniques; Male; Phenethylamines; Purinergic P1 Receptor Agonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Synaptosomes; Triazoles; Xanthines | 2002 |
Adenosine A(2A) receptor facilitation of hippocampal synaptic transmission is dependent on tonic A(1) receptor inhibition.
Topics: Adenosine; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Humans; In Vitro Techniques; Ligands; Male; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Signal Transduction; Synaptic Transmission; Transfection; Triazines; Triazoles; Xanthines | 2002 |
Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blotting, Western; Cells, Cultured; Drosophila Proteins; Endothelial Growth Factors; Female; Interferon-gamma; Lipopolysaccharides; Lymphokines; Macrophages, Peritoneal; Male; Membrane Glycoproteins; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phenethylamines; Protein Kinase Inhibitors; Purinergic P1 Receptor Agonists; Receptor, Adenosine A2A; Receptors, Cell Surface; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Theobromine; Toll-Like Receptor 4; Toll-Like Receptors; Triazines; Triazoles; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Xanthines | 2002 |
Selective allosteric enhancement of agonist binding and function at human A3 adenosine receptors by a series of imidazoquinoline derivatives.
Topics: Adenosine; Allosteric Regulation; Animals; Binding, Competitive; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Imidazoles; Iodine Radioisotopes; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Quinolines; Radioligand Assay; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Triazines; Triazoles; Tritium; Xanthines | 2002 |
Effects of adenosine receptor agonists on guinea-pig isolated working hearts and the role of endothelium and NO.
Topics: Adenosine; Animals; Cyclooxygenase Inhibitors; Endothelium, Vascular; Guinea Pigs; Heart; Hemodynamics; In Vitro Techniques; Indomethacin; Male; Nitric Oxide; Nitric Oxide Synthase; Phenethylamines; Prostaglandins; Purinergic P1 Receptor Agonists; Triazines; Triazoles | 2002 |
Effects of A(1) and A(2A) adenosine receptor ligands in mouse acute models of pain.
Topics: Acute Disease; Adenosine; Animals; Behavior, Animal; Ligands; Mice; Nociceptors; Pain; Pain Measurement; Pyrimidines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Triazoles | 2002 |
Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine.
Topics: Adenosine; Animals; Caffeine; Central Nervous System Stimulants; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Dopamine and cAMP-Regulated Phosphoprotein 32; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neostriatum; Nerve Tissue Proteins; Neurons; Phenethylamines; Phosphoproteins; Phosphorylation; Phosphothreonine; Purinergic P1 Receptor Antagonists; Pyrimidines; Receptors, Purinergic P1; Triazoles | 2002 |
Autocrine activation of adenosine A1 receptors blocks D1A but not D1B dopamine receptor desensitization.
Topics: Adenosine; Animals; Autocrine Communication; Cell Line; COS Cells; Cyclic AMP; Dopamine Agonists; Fibroblasts; Mice; Phosphodiesterase Inhibitors; Quinazolines; Receptors, Dopamine D1; Receptors, Dopamine D5; Receptors, Purinergic P1; Time Factors; Transfection; Triazoles; Xanthines | 2002 |
Broad spectrum anticonvulsant activity of BW534U87: possible role of an adenosine-dependent mechanism.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Amygdala; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Electroshock; Enzyme Inhibitors; Female; Kindling, Neurologic; Male; Mice; Pentylenetetrazole; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Seizures; Triazoles; Xanthines | 2002 |
Positive coupling of atypical adenosine A3 receptors on human eosinophils to adenylyl cyclase.
Topics: Adenosine; Adenylyl Cyclases; Adult; Cell Degranulation; Cyclic AMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Eosinophils; Histamine; Humans; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Triazoles | 2003 |
ATP protects, by way of receptor-mediated mechanisms, against hypoxia-induced injury in renal proximal tubules.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Energy Metabolism; Hemolysis; Hypotonic Solutions; Hypoxia; Kidney Tubules, Proximal; Kinetics; L-Lactate Dehydrogenase; Male; Potassium; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Thionucleotides; Triazoles | 2003 |
Regional differences in the adenosine A(2) receptor-mediated modulation of contractions in rat vas deferens.
Topics: Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Epididymis; Immunohistochemistry; In Vitro Techniques; Male; Muscle Contraction; Norepinephrine; Phenethylamines; Prostate; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theobromine; Triazines; Triazoles; Vas Deferens; Xanthines | 2003 |
Adenosine promotes neuronal recovery from reactive oxygen species induced lesion in rat hippocampal slices.
Topics: Adenosine; Animals; Excitatory Postsynaptic Potentials; Fluorometry; Hippocampus; In Vitro Techniques; Male; Neurons; Oxidative Stress; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Wistar; Reactive Oxygen Species; Receptor, Adenosine A2A; Synaptic Transmission; Triazoles; Xanthines | 2003 |
Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration.
Topics: Adenosine; Amphetamine; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Male; Motor Activity; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theophylline; Time Factors; Triazines; Triazoles; Tritium; Xanthines | 2003 |
A2A and A3 receptors mediate the adenosine-induced relaxation in spontaneously active possum duodenum in vitro.
Topics: Adenosine; Animals; Duodenum; Female; In Vitro Techniques; Male; Opossums; Purinergic P1 Receptor Antagonists; Pyrrolidinones; Quinazolines; Receptors, Purinergic P1; Tetrodotoxin; Time Factors; Triazoles; Xanthines | 2003 |
Induction of neurite outgrowth in PC12 cells by the bacterial nucleoside N6-methyldeoxyadenosine is mediated through adenosine A2a receptors and via cAMP and MAPK signaling pathways.
Topics: Adenosine; Animals; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cyclic AMP; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Deoxyadenosines; DNA-Binding Proteins; Enzyme Inhibitors; ets-Domain Protein Elk-1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Neurites; PC12 Cells; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Second Messenger Systems; Transcription Factors; Triazines; Triazoles | 2003 |
Binding of HTLV-1 virions to T cells occurs by a temperature and calcium-dependent process and is blocked by certain type 2 adenosine receptor antagonists.
Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Antibodies, Monoclonal; Calcium; Cations, Divalent; Cell Line, Transformed; Human T-lymphotropic virus 1; Humans; Kinetics; Membrane Microdomains; Phenethylamines; Purinergic P1 Receptor Agonists; Quinazolines; T-Lymphocytes; Thermodynamics; Triazoles | 2003 |
The human D2 dopamine receptor synergizes with the A2A adenosine receptor to stimulate adenylyl cyclase in PC12 cells.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenine; Adenosine; Adenosine Deaminase; Adenosine Diphosphate; Adenylyl Cyclases; Animals; Benzamides; Binding, Competitive; Cell Cycle; Cell Membrane; Cofilin 1; Colforsin; Cyclic AMP; Cytoskeletal Proteins; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Enzyme Activation; Gene Expression; Glutamic Acid; Humans; Membrane Potentials; Patch-Clamp Techniques; PC12 Cells; Pertussis Toxin; Phenethylamines; Phosphodiesterase Inhibitors; Phosphoproteins; Propionates; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrrolidines; Quinpirole; Radioligand Assay; Rats; Receptors, Dopamine D2; Receptors, Purinergic P1; Thionucleotides; Transfection; Triazines; Triazoles; Xenopus Proteins | 2003 |
Blockade of A2A adenosine receptors prevents basic fibroblast growth factor-induced reactive astrogliosis in rat striatal primary astrocytes.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Animals, Newborn; Astrocytes; Cell Division; Cells, Cultured; Cerebral Cortex; Corpus Striatum; Dose-Response Relationship, Drug; Drug Interactions; Fibroblast Growth Factor 2; Fluorescent Antibody Technique; Glial Fibrillary Acidic Protein; Gliosis; Neuroprotective Agents; Phenethylamines; Purines; Pyrimidines; Rats; Receptor, Adenosine A2A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triazoles; Vasodilator Agents | 2003 |
Adenosine A 2B receptors modulate cAMP levels and induce CREB but not ERK1/2 and p38 phosphorylation in rat skeletal muscle cells.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cells, Cultured; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phenethylamines; Phosphorylation; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptors, Purinergic P1; RNA; Triazines; Triazoles | 2003 |
Adenosine A(2A) antagonism increases striatal glutamate outflow in the quinolinic acid rat model of Huntington's disease.
Topics: Adenosine; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Extracellular Space; Glutamic Acid; Huntington Disease; Male; Microdialysis; Models, Animal; Neuroprotective Agents; Purinergic P1 Receptor Antagonists; Pyrimidines; Quinolinic Acid; Rats; Rats, Wistar; Receptor, Adenosine A2A; Time Factors; Triazoles | 2003 |
Interactive role of adenosine and dopamine in the opiate withdrawal syndrome.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Chromatography, High Pressure Liquid; Dopamine; Injections, Subcutaneous; Male; Microdialysis; Morphine; Pyrimidines; Rats; Rats, Wistar; Receptors, Dopamine; Substance Withdrawal Syndrome; Triazoles | 2003 |
Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hippocampus of aged rats.
Topics: Adenosine; Adrenergic beta-Agonists; Aging; Animals; Blotting, Western; Cyclic AMP; Electrophysiology; Excitatory Postsynaptic Potentials; Hippocampus; Isoproterenol; Male; Neurons; Phenethylamines; Presynaptic Terminals; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Synaptic Transmission; Triazines; Triazoles; Xanthines | 2003 |
Effects of adenosine receptor antagonists on pial arteriolar dilation during carbon dioxide inhalation.
Topics: Adenosine; Administration, Inhalation; Animals; Caffeine; Carbon Dioxide; Cerebral Cortex; Cerebral Veins; Cerebrovascular Circulation; Drug Interactions; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Sprague-Dawley; Triazines; Triazoles; Vasodilation; Vasodilator Agents; Xanthines | 2003 |
The effect of caffeine on peripheral vascular resistance in isolated perfused guinea pig hind limbs.
Topics: Adenosine; Animals; Caffeine; Dose-Response Relationship, Drug; Female; Flavins; Guinea Pigs; Hindlimb; Hypoxia; Iliac Artery; Iloprost; Male; Nitrogen; Norepinephrine; Perfusion; Triazines; Triazoles; Vascular Resistance; Vasoconstriction; Vasodilation | 2003 |
LTP-induced depression of response to hypoxia in hippocampus: effects of adenosine receptor activation.
Topics: Adenosine; Animals; Electric Stimulation; Hippocampus; Hypoxia; In Vitro Techniques; Long-Term Potentiation; Male; Membrane Potentials; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Triazines; Triazoles | 2003 |
Adenosine A2A receptors and depression.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Antidepressive Agents; Behavior, Animal; Caffeine; Depression; Disease Models, Animal; Dopamine Antagonists; Drug Interactions; Haloperidol; Mice; Mice, Knockout; Motor Activity; Neurotransmitter Agents; Parkinsonian Disorders; Purines; Pyrimidines; Receptor, Adenosine A2A; Triazines; Triazoles | 2003 |
Discovery of nonxanthine adenosine A2A receptor antagonists for the treatment of Parkinson's disease.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Humans; Ligands; Mefloquine; Mice; Motor Activity; Neuroprotective Agents; Parkinsonian Disorders; Phenethylamines; Purines; Pyrimidines; Radioligand Assay; Rats; Triazines; Triazoles | 2003 |
Input-specific modulation of neurotransmitter release in the lateral horn of the spinal cord via adenosine receptors.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Cells, Cultured; Excitatory Postsynaptic Potentials; Immunohistochemistry; Interneurons; Male; Neural Inhibition; Neurons; Neurotransmitter Agents; Patch-Clamp Techniques; Phenethylamines; Presynaptic Terminals; Rats; Receptor, Adenosine A1; Receptor, Adenosine A2A; Spinal Cord; Triazines; Triazoles | 2004 |
Adenosine administration produces an antidepressant-like effect in mice: evidence for the involvement of A1 and A2A receptors.
Topics: Adenosine; Animals; Antidepressive Agents; Caffeine; Depressive Disorder; Disease Models, Animal; Female; Male; Mice; Motor Activity; Receptor, Adenosine A1; Receptor, Adenosine A2A; Stress, Psychological; Triazines; Triazoles; Xanthines | 2004 |
Role of adenosine A2A receptor in the regulation of gastric somatostatin release.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Gastric Mucosa; Male; Phenethylamines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Somatostatin; Stomach; Tissue Distribution; Triazines; Triazoles; Xanthines | 2004 |
Effect of taurine deficiency on adenosine receptor-mediated relaxation of the rat aorta.
Topics: 2-Chloroadenosine; Acetylcholine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Aorta, Thoracic; beta-Alanine; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phenylephrine; Rats; Rats, Inbred WKY; Receptors, Purinergic P1; Taurine; Triazines; Triazoles; Vasoconstrictor Agents; Vasodilator Agents | 2003 |
Neutrophils both reduce and increase permeability in a cell culture model of the blood-brain barrier.
Topics: Adenosine; Adenosine Deaminase; Animals; Aprotinin; Blood-Brain Barrier; Capillary Permeability; Catalase; Cell Culture Techniques; Cell Movement; Cells, Cultured; Egtazic Acid; Electric Impedance; Endothelial Cells; Free Radicals; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Superoxide Dismutase; Triazines; Triazoles | 2004 |
Synthesis and structure-activity relationships of 4-cycloalkylamino-1, 2, 4-triazolo[4, 3-a]quinoxalin-1- one derivatives as A1 and A3 adenosine receptor antagonists.
Topics: Adenosine; Alkanes; Animals; Binding Sites; Binding, Competitive; Cattle; Cerebral Cortex; CHO Cells; Cricetinae; Humans; Iodine Isotopes; Membranes; Neostriatum; Phenethylamines; Purinergic Antagonists; Quantitative Structure-Activity Relationship; Quinoxalines; Receptors, Purinergic; Triazoles; Tritium | 2004 |
1,2,4-Triazolo[1,5-a]quinoxaline derivatives: synthesis and biological evaluation as adenosine receptor antagonists.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Antagonists; Animals; Binding, Competitive; Cattle; Cerebral Cortex; CHO Cells; Cricetinae; Humans; In Vitro Techniques; Indicators and Reagents; Kinetics; Magnetic Resonance Spectroscopy; Neostriatum; Purinergic P1 Receptor Antagonists; Quinoxalines; Spectrophotometry, Infrared; Structure-Activity Relationship; Triazoles | 2004 |
Binding of the prototypical adenosine A(2A) receptor agonist CGS 21680 to the cerebral cortex of adenosine A(1) and A(2A) receptor knockout mice.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Animals; Autoradiography; Basal Ganglia; Binding, Competitive; Blotting, Western; Cerebral Cortex; Electrophoresis, Polyacrylamide Gel; Mice; Mice, Knockout; Models, Animal; Phenethylamines; Pyrimidines; Receptor, Adenosine A1; Receptor, Adenosine A2A; Triazoles; Tritium; Xanthines | 2004 |
Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic transmission in hippocampal slices.
Topics: Adenosine; Adenosine Kinase; Animals; Brain-Derived Neurotrophic Factor; Bucladesine; Carbazoles; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Indole Alkaloids; Long-Term Potentiation; Male; Patch-Clamp Techniques; Phenethylamines; Potassium; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptor, trkB; Synaptic Transmission; Triazines; Triazoles | 2004 |
Endogenous adenosine modulates epileptiform activity in rat hippocampus in a receptor subtype-dependent manner.
Topics: Adenosine; Animals; Animals, Newborn; Dihydropyridines; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Indoles; Maleimides; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Seizures; Theophylline; Time Factors; Triazines; Triazoles | 2004 |
The role of intraspinal adenosine A1 receptors in sympathetic regulation.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Dihydropyridines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Spinal Cord; Splanchnic Nerves; Sympathetic Nervous System; Synaptic Transmission; Theobromine; Theophylline; Triazines; Triazoles | 2004 |
Adenosine A2A receptor occupancy stimulates expression of proteins involved in reverse cholesterol transport and inhibits foam cell formation in macrophages.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Arteriosclerosis; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Carrier Proteins; Cell Differentiation; Cholestanetriol 26-Monooxygenase; Cholesterol; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Foam Cells; Gene Expression Regulation, Enzymologic; Humans; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phenethylamines; Receptor, Adenosine A2A; RNA, Messenger; Steroid Hydroxylases; Triazines; Triazoles; Up-Regulation | 2004 |
Adenosine A2A receptor blockade differentially influences excitotoxic mechanisms at pre- and postsynaptic sites in the rat striatum.
Topics: 4-Aminopyridine; Adenosine; Adenosine A2 Receptor Antagonists; Animals; Calcium; Corpus Striatum; Dose-Response Relationship, Drug; Glutamic Acid; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Models, Biological; N-Methylaspartate; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Phenethylamines; Pyrimidines; Quinolinic Acid; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes; Synaptic Transmission; Triazines; Triazoles | 2004 |
Adenosine's role in hypercapnia-evoked cerebral vasodilation in the rat.
Topics: Adenosine; Animals; Carbon Dioxide; Cerebrovascular Circulation; Hypercapnia; Male; Microscopy, Video; Nitric Oxide; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Triazines; Triazoles; Vasodilation | 2004 |
Facilitation of noradrenaline release by activation of adenosine A(2A) receptors triggers both phospholipase C and adenylate cyclase pathways in rat tail artery.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenylyl Cyclases; Animals; Arteries; Cyclic AMP-Dependent Protein Kinases; Endothelium, Vascular; Enzyme Activation; Indoles; Isoquinolines; Male; Norepinephrine; Phenethylamines; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Receptor, Adenosine A2A; Signal Transduction; Sulfonamides; Tail; Tetradecanoylphorbol Acetate; Triazoles; Tritium; Type C Phospholipases | 2004 |
Permissive role of adenosine A2A receptors on metabotropic glutamate receptor 5 (mGluR5)-mediated effects in the striatum.
Topics: Adenosine; Animals; Carbazoles; Cells, Cultured; Corpus Striatum; Dose-Response Relationship, Drug; Drug Interactions; Electrophysiology; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glycine; In Vitro Techniques; Indoles; Male; Membrane Potentials; N-Methylaspartate; Phenethylamines; Phenylacetates; Pregnancy; Purinergic P1 Receptor Agonists; Pyridines; Pyrroles; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Adenosine A2; Receptors, Metabotropic Glutamate; Triazines; Triazoles | 2004 |
Adenosine and glutamate extracellular concentrations and mitogen-activated protein kinases in the striatum of Huntington transgenic mice. Selective antagonism of adenosine A2A receptors reduces transmitter outflow.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Corpus Striatum; Extracellular Fluid; Glutamic Acid; Huntington Disease; Male; Mice; Mice, Inbred CBA; Mice, Transgenic; Mitogen-Activated Protein Kinases; Pyrimidines; Receptor, Adenosine A2A; Triazoles | 2004 |
Adenosine A1 receptors modulate the anxiolytic-like effect of ethanol in the elevated plus-maze in mice.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Caffeine; Dose-Response Relationship, Drug; Drug Synergism; Ethanol; Male; Maze Learning; Mice; Receptor, Adenosine A1; Triazines; Triazoles; Xanthines | 2004 |
Regulation of A2B adenosine receptor functioning by tumour necrosis factor a in human astroglial cells.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Antineoplastic Agents; Astrocytes; Astrocytoma; Blotting, Western; Cell Growth Processes; Cell Line, Tumor; Cricetinae; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Immunoprecipitation; Neuroprotective Agents; Phenethylamines; Purines; Pyrimidines; Radioligand Assay; Receptor, Adenosine A2B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Threonine; Time Factors; Transfection; Triazoles; Tumor Necrosis Factor-alpha | 2004 |
Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxia.
Topics: 5'-Nucleotidase; Adenosine; Animals; Capillary Permeability; Hypoxia; Lung; Mice; Triazines; Triazoles | 2004 |
A2A adenosine receptor induction inhibits IFN-gamma production in murine CD4+ T cells.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; CD4-Positive T-Lymphocytes; Cell Line; Cyclic AMP; Cyclohexanecarboxylic Acids; Gene Dosage; Humans; Interferon-gamma; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Purines; Receptor, Adenosine A2A; Receptors, Antigen, T-Cell; RNA, Messenger; Rolipram; Triazines; Triazoles | 2005 |
A2B adenosine receptor mediates human chorionic vasoconstriction and signals through arachidonic acid cascade.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Arachidonic Acid; Chorion; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Placenta; Pregnancy; Receptor, Adenosine A2B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Triazines; Triazoles; Vasoconstriction; Vasodilator Agents; Xanthines | 2005 |
Co-localization and functional interaction between adenosine A(2A) and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Neostriatum; Phenethylamines; Presynaptic Terminals; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Subcellular Fractions; Synaptosomes; Triazoles; Xanthines | 2005 |
Kinetic and functional properties of [3H]ZM241385, a high affinity antagonist for adenosine A2A receptors.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Algorithms; Animals; Binding, Competitive; Cell Membrane; CHO Cells; Cricetinae; Cyclic AMP; GTP-Binding Proteins; Kinetics; Ligands; Neostriatum; Phenethylamines; Radioligand Assay; Triazines; Triazoles | 2005 |
Adenosine contributes to mu-opioid synaptic inhibition in rat substantia gelatinosa in vitro.
Topics: Adenosine; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Postsynaptic Potentials; Neural Inhibition; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Rats; Receptors, Opioid, mu; Receptors, Purinergic P1; Substantia Gelatinosa; Synapses; Triazines; Triazoles; Xanthines | 2005 |
Upregulation of A2A adenosine receptor expression by TNF-alpha in PBMC of patients with CHF: a regulatory mechanism of inflammation.
Topics: Adenosine; Blotting, Western; Female; Heart Failure; Humans; Lipopolysaccharides; Male; Middle Aged; Neutrophils; Phenethylamines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; Triazines; Triazoles; Tumor Necrosis Factor-alpha; Up-Regulation | 2005 |
Modulation of short-term social memory in rats by adenosine A1 and A(2A) receptors.
Topics: Adenosine; Animals; Behavior, Animal; Brain; Caffeine; Dose-Response Relationship, Drug; Drug Administration Schedule; Injections, Intraperitoneal; Male; Memory, Short-Term; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Adenosine A2A; Social Behavior; Triazines; Triazoles; Xanthines | 2005 |
Antiinflammatory effect of A3 adenosine receptor agonists in murine autoimmune arthritis models.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Collagen; Dose-Response Relationship, Drug; Female; Joints; Lymph Nodes; Male; Mice; Mice, Inbred DBA; Quinazolines; Rats; Receptor, Adenosine A3; Spleen; Triazoles; Tumor Necrosis Factor-alpha | 2005 |
Adenosine agonist regulation of outward active transport of fluorescein across retinal pigment epithelium in rabbits.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Biological Transport, Active; Dihydropyridines; Fluorescein; Fluoresceins; Fluorophotometry; Injections, Intravenous; Male; Pigment Epithelium of Eye; Purinergic P1 Receptor Antagonists; Rabbits; Retinal Detachment; Triazines; Triazoles; Xanthines | 2005 |
Activation of adenosine receptors in the posterior cingulate cortex impairs memory retrieval in the rat.
Topics: Adenosine; Animals; Avoidance Learning; Cerebral Cortex; Exploratory Behavior; Gyrus Cinguli; Male; Memory; Microinjections; Phenethylamines; Purinergic Agonists; Purinergic Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Adenosine A2A; Triazines; Triazoles; Xanthines | 2005 |
Effects of adenosine and adenosine A2A receptor agonist on motor nerve conduction velocity and nerve blood flow in experimental diabetic neuropathy.
Topics: Adenosine; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Neural Conduction; Phenethylamines; Purinergic P2 Receptor Agonists; Rats; Regional Blood Flow; Sciatic Nerve; Staining and Labeling; Streptozocin; Theophylline; Time Factors; Triazines; Triazoles | 2005 |
Adenosine A2A receptors control the extracellular levels of adenosine through modulation of nucleoside transporters activity in the rat hippocampus.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Extracellular Fluid; Hippocampus; Nucleoside Transport Proteins; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Triazoles | 2005 |
Adenosine signaling promotes neuronal, catecholaminergic differentiation of primary neural crest cells and CNS-derived CAD cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine-5'-(N-ethylcarboxamide); Adrenal Medulla; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Catecholamines; Cell Differentiation; Cell Line; Cells, Cultured; Chromaffin Cells; Coturnix; Culture Media, Serum-Free; Cyclic AMP; Neural Crest; Neurons; Quinazolines; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Signal Transduction; Sympathetic Nervous System; Transforming Growth Factor beta; Triazoles; Tyrosine 3-Monooxygenase | 2005 |
Does conversion of ATP to adenosine terminate ATP-stimulated vasopressin release from hypothalamo-neurohypophyseal explants?
Topics: 5'-Nucleotidase; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine Triphosphate; Animals; Enzyme Inhibitors; Hypothalamo-Hypophyseal System; Male; Organ Culture Techniques; Pituitary Gland, Posterior; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptors, Purinergic P1; Supraoptic Nucleus; Time Factors; Triazoles; Vasopressins; Water-Electrolyte Balance; Xanthines | 2005 |
Postconditioning reduces infarct size via adenosine receptor activation by endogenous adenosine.
Topics: Adenosine; Animals; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Perfusion; Purinergic P1 Receptor Antagonists; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Xanthines | 2005 |
Cross-talk between adenosine and the oxatriazole derivative GEA 3175 in platelets.
Topics: Adenosine; Blood Platelets; Calcium; Cyclic AMP; Cyclic GMP; Cytosol; Drug Interactions; Enzyme Inhibitors; Guanylate Cyclase; Humans; Milrinone; Oxadiazoles; Phosphodiesterase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinoxalines; Thrombin; Time Factors; Triazoles | 2005 |
Modulation of seizures and synaptic plasticity by adenosinergic receptors in an experimental model of temporal lobe epilepsy induced by pilocarpine in rats.
Topics: 5'-Nucleotidase; Adenosine; Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; In Situ Nick-End Labeling; Male; Neuronal Plasticity; Neuroprotective Agents; Pilocarpine; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Wistar; Receptors, Purinergic P1; Status Epilepticus; Synapses; Triazoles; Xanthines | 2005 |
Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Animals, Newborn; Blotting, Western; Cell Proliferation; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Immunohistochemistry; Indoles; Lipopolysaccharides; Maleimides; Mice; Mice, Inbred C57BL; Microglia; Nitric Oxide; Nitrites; Phenethylamines; Protein Binding; Radioligand Assay; Receptor, Adenosine A2A; Time Factors; Triazines; Triazoles; Tritium; Tumor Necrosis Factor-alpha | 2005 |
The cellular mechanisms by which adenosine evokes release of nitric oxide from rat aortic endothelium.
Topics: Adenosine; Animals; Aorta, Thoracic; Apamin; Arachidonic Acids; Calcium; Endothelium, Vascular; In Vitro Techniques; Large-Conductance Calcium-Activated Potassium Channels; Male; Nitric Oxide; Peptides; Phospholipases A; Phospholipases A2; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptors, Adenosine A2; Second Messenger Systems; Small-Conductance Calcium-Activated Potassium Channels; Triazines; Triazoles; Vasodilator Agents; Xanthines | 2006 |
Adenosine concentration in the porcine coronary artery wall and A2A receptor involvement in hypoxia-induced vasodilatation.
Topics: Acetamides; Adenosine; Adenosine A2 Receptor Antagonists; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Coronary Vessels; Dose-Response Relationship, Drug; Glucose; Hypoxia; In Vitro Techniques; Lactates; Purines; Pyruvic Acid; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Swine; Triazines; Triazoles; Vasodilation | 2006 |
Adenosine A1 and A2A receptors of hippocampal CA1 region have opposite effects on piriform cortex kindled seizures in rats.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Cerebral Cortex; Electric Stimulation; Hippocampus; Kindling, Neurologic; Male; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptors, Purinergic P2; Seizures; Triazines; Triazoles; Xanthines | 2006 |
Inosine released after hypoxia activates hepatic glucose liberation through A3 adenosine receptors.
Topics: Adenosine; Adenosine A3 Receptor Antagonists; Animals; Calcium; Cell Hypoxia; Cyclic AMP; Gluconeogenesis; Glucose; Glycogen Phosphorylase; Glycogenolysis; Hepatocytes; Inosine; Liver; Male; Phylogeny; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Wistar; Receptor, Adenosine A3; Receptors, G-Protein-Coupled; Receptors, Purinergic; Receptors, Purinergic P1; Triazoles; Urea | 2006 |
Adenosine A2A receptors promote adenosine-stimulated wound healing in bronchial epithelial cells.
Topics: Adenosine; Bronchi; Cell Division; Cell Line; Cell Movement; Humans; Kinetics; Receptor, Adenosine A2A; Respiratory Mucosa; Transcription, Genetic; Triazines; Triazoles; Wound Healing; Wounds and Injuries | 2006 |
A2a receptors mediate inhibitory effects of adenosine on colonic motility in the presence of experimental colitis.
Topics: Adenosine; Animals; Colitis; Disease Models, Animal; Gastrointestinal Motility; Intestinal Mucosa; Male; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity; Tissue Culture Techniques; Triazines; Triazoles | 2006 |
Adenosine as an active component of Antrodia cinnamomea that prevents rat PC12 cells from serum deprivation-induced apoptosis through the activation of adenosine A(2A) receptors.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Aminohydrolases; Animals; Apoptosis; Culture Media, Serum-Free; Inosine; PC12 Cells; Polyporales; Rats; Triazines; Triazoles | 2006 |
Dialysis delivery of an adenosine A2A agonist into the pontine reticular formation of C57BL/6J mouse increases pontine acetylcholine release and sleep.
Topics: Acetylcholine; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Dose-Response Relationship, Drug; Extracellular Fluid; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Microdialysis; Neural Inhibition; Neural Pathways; Phenethylamines; Pons; Receptor, Adenosine A2A; Reticular Formation; Sleep; Sleep, REM; Synaptic Transmission; Triazines; Triazoles; Up-Regulation; Wakefulness | 2006 |
Schwann cells in rat vascular autonomic nerves activated via purinergic receptors.
Topics: Adenosine; Adenosine Triphosphate; Animals; Autonomic Nervous System; Calcium; Quinazolines; Rats; Rats, Wistar; Receptors, Purinergic; Schwann Cells; Splanchnic Circulation; Suramin; Triazoles; Uridine Triphosphate | 2006 |
Radioligand binding and functional responses of ligands for human recombinant adenosine A(3) receptors.
Topics: Adenosine; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Iodine Radioisotopes; Ligands; Magnesium Chloride; Quinazolines; Radioligand Assay; Receptor, Adenosine A3; Recombinant Proteins; Transfection; Triazoles | 2006 |
Adenosine modulates vascular endothelial growth factor expression via hypoxia-inducible factor-1 in human glioblastoma cells.
Topics: Adenosine; Adenosine A3 Receptor Antagonists; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Neoplastic; Gene Silencing; Glioblastoma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phenylurea Compounds; Receptor, Adenosine A3; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Triazoles; Up-Regulation; Vascular Endothelial Growth Factor A | 2006 |
Adenosine A2A receptor stimulation decreases GAT-1-mediated GABA uptake in the globus pallidus of the rat.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenosine A2 Receptor Agonists; Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; Data Interpretation, Statistical; Enzyme Inhibitors; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Globus Pallidus; In Vitro Techniques; Isoquinolines; Male; Okadaic Acid; Phenethylamines; Rats; Rats, Wistar; Sulfonamides; Synapses; Triazines; Triazoles | 2006 |
Role of adenosine A1 receptors in the modulation of dopamine D1 and adenosine A2A receptor signaling in the neostriatum.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Benzazepines; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopamine Antagonists; Drug Interactions; Gene Expression; In Vitro Techniques; Mice; Mice, Inbred C57BL; Neostriatum; Phenethylamines; Raclopride; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptors, Dopamine D1; Signal Transduction; Threonine; Triazines; Triazoles; Xanthines | 2006 |
Characterization of [125I]ZM 241385 binding to adenosine A2A receptors in the pineal of sheep brain.
Topics: Adenosine; Algorithms; Animals; Autoradiography; Binding Sites; Binding, Competitive; Brain; Brain Chemistry; Data Interpretation, Statistical; Diencephalon; Female; In Vitro Techniques; Iodine Radioisotopes; Membranes; Pineal Gland; Pregnancy; Receptor, Adenosine A2A; Receptors, G-Protein-Coupled; Sheep; Thalamic Nuclei; Triazines; Triazoles | 2006 |
Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Blotting, Western; Caffeine; Carbon Tetrachloride; Cell Line; Chromatography, High Pressure Liquid; Ethanol; Hepatocytes; Humans; Liver Cirrhosis; Matrix Metalloproteinases, Membrane-Associated; Methotrexate; Mice; Mice, Inbred C57BL; Rats; Receptor, Adenosine A2A; Reverse Transcriptase Polymerase Chain Reaction; Thioacetamide; Triazines; Triazoles | 2006 |
Docking studies of agonists and antagonists suggest an activation pathway of the A3 adenosine receptor.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Animals; Binding Sites; Computer Simulation; Humans; Hydrogen Bonding; Imidazoles; In Vitro Techniques; Ligands; Models, Molecular; Phenylurea Compounds; Protein Conformation; Purines; Rats; Receptor, Adenosine A3; Receptor, Muscarinic M3; Structure-Activity Relationship; Triazoles | 2006 |
Evidence for both adenosine A1 and A2A receptors activating single vagal sensory C-fibres in guinea pig lungs.
Topics: Action Potentials; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Capsaicin; Gene Expression Regulation; Guinea Pigs; Lung; Male; Nerve Fibers, Unmyelinated; Neurons; Nodose Ganglion; Patch-Clamp Techniques; Phenethylamines; Pyrimidines; Receptor, Adenosine A1; Receptors, Adenosine A2; RNA, Messenger; Triazoles; Xanthines | 2006 |
Caffeine inhibition of rat carotid body chemoreceptors is mediated by A2A and A2B adenosine receptors.
Topics: Adenosine; Animals; Caffeine; Carotid Body; Catecholamines; Central Nervous System Stimulants; Chemoreceptor Cells; Dose-Response Relationship, Drug; Female; Hypoxia; Immunohistochemistry; Male; Potassium; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptors, Presynaptic; Respiratory Mechanics; Triazines; Triazoles; Xanthines | 2006 |
Contribution of adenosine receptors in the control of arteriolar tone and adenosine-angiotensin II interaction.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Angiotensin II; Animals; Arterioles; Feedback; Female; Kidney Glomerulus; Kidney Tubules; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenethylamines; Purines; Receptor, Adenosine A1; Receptors, Adenosine A2; Theophylline; Triazines; Triazoles; Vasoconstriction; Vasodilation | 2006 |
Adenosine A2A receptor modulation of juvenile female rat skeletal muscle microvessel permeability.
Topics: Adenine; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Aging; Animals; Arterioles; Cell Membrane Permeability; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gene Expression Regulation; Muscle, Skeletal; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A2B; RNA, Messenger; Serum Albumin; Triazines; Triazoles; Vasodilator Agents; Venules | 2006 |
Inhibitory responses to exogenous adenosine in murine proximal and distal colon.
Topics: Adenosine; Animals; Colon; Dose-Response Relationship, Drug; Enzyme Inhibitors; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Purinergic P1 Receptor Antagonists; Quinazolines; Receptors, Purinergic P1; Signal Transduction; Theobromine; Triazoles; Xanthines | 2006 |
Glial cell line-derived neurotrophic factor (GDNF) enhances dopamine release from striatal nerve endings in an adenosine A2A receptor-dependent manner.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Bicuculline; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; GABA Antagonists; Glial Cell Line-Derived Neurotrophic Factor; In Vitro Techniques; Male; Nerve Endings; Phenethylamines; Potassium; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Synaptosomes; Triazoles; Tritium | 2006 |
Cl-IB-MECA [2-chloro-N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide] reduces ischemia/reperfusion injury in mice by activating the A3 adenosine receptor.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Blood Pressure; Cardiotonic Agents; Cell Degranulation; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Histamine; In Vitro Techniques; Male; Mice; Mice, Knockout; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; p-Methoxy-N-methylphenethylamine; Pyridines; Radioligand Assay; Receptor, Adenosine A3; Triazines; Triazoles | 2006 |
Expression of adenosine receptors in cardiac fibroblasts as a function of insulin and glucose level.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Animals; Blotting, Western; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression; Glucose; Heart Ventricles; Insulin; Male; Phenethylamines; Protein Isoforms; Rats; Rats, Wistar; Receptors, Purinergic P1; RNA, Messenger; Triazines; Triazoles | 2006 |
Stimulation of adenosine A1 and A2A receptors by AMP in the submucosal plexus of guinea pig small intestine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine Diphosphate; Adenosine Monophosphate; Animals; Boron Compounds; Enzyme Inhibitors; Estrenes; Excitatory Postsynaptic Potentials; Guinea Pigs; Ileum; Indoles; Male; Maleimides; Norepinephrine; Phenethylamines; Pyrrolidinones; Quinazolines; Receptor, Adenosine A1; Receptor, Adenosine A2A; Signal Transduction; Submucous Plexus; Synaptic Transmission; Tetrodotoxin; Theophylline; Triazines; Triazoles | 2007 |
Tonic adenosine A1 and A2A receptor activation is required for the excitatory action of VIP on synaptic transmission in the CA1 area of the hippocampus.
Topics: Adenosine; Adenosine Deaminase; Analysis of Variance; Animals; Drug Interactions; Electric Stimulation; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Neuroprotective Agents; Patch-Clamp Techniques; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Adenosine A2A; Synaptic Transmission; Triazines; Triazoles; Vasoactive Intestinal Peptide; Xanthines | 2007 |
2-triazole-substituted adenosines: a new class of selective A3 adenosine receptor agonists, partial agonists, and antagonists.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Animals; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Humans; Models, Molecular; Radioligand Assay; Structure-Activity Relationship; Triazoles | 2006 |
A novel mechanism of vasoregulation: ADP-induced relaxation of the porcine isolated coronary artery is mediated via adenosine release.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Coronary Vessels; Dose-Response Relationship, Drug; Female; Gene Expression; In Vitro Techniques; Male; Molecular Sequence Data; Purinergic P1 Receptor Antagonists; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Pyrimidines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Receptors, Purinergic P2; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Swine; Triazoles; Vasodilation; Vasodilator Agents | 2007 |
Cell death in rat cerebellar granule neurons induced by hydrogen peroxide in vitro: mechanisms and protection by adenosine receptor ligands.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Animals, Newborn; Apoptosis; Brain Diseases; Catalase; Cell Death; Cell Survival; Cells, Cultured; Cerebellar Cortex; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydrogen Peroxide; Necrosis; Neurons; Oxidative Stress; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptors, Adenosine A2; Receptors, Purinergic P1; Time Factors; Triazines; Triazoles | 2007 |
The novel adenosine A2a antagonist ST1535 potentiates the effects of a threshold dose of l-dopa in unilaterally 6-OHDA-lesioned rats.
Topics: Adenine; Adenosine; Adenosine A2 Receptor Antagonists; Animals; Brain; Disease Models, Animal; Dopamine Agents; Dose-Response Relationship, Drug; Drug Synergism; Exploratory Behavior; Levodopa; Male; Movement; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Receptor, Adenosine A2A; Sympatholytics; Triazoles | 2007 |
Characterization of the potency, selectivity, and pharmacokinetic profile for six adenosine A2A receptor antagonists.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Antagonists; Animals; Binding, Competitive; Biological Availability; Cell Line; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Male; Metabolic Clearance Rate; Molecular Structure; PC12 Cells; Phenethylamines; Purines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptor, Adenosine A3; Theobromine; Triazines; Triazoles; Xanthines | 2007 |
The role of adenosine A2a receptors in experimental acute pancreatitis.
Topics: Acute Disease; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Amylases; Animals; Disease Models, Animal; Immunohistochemistry; Lipase; Male; Pancreas; Pancreatitis; Phenethylamines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Taurocholic Acid; Triazines; Triazoles | 2006 |
Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration via the adenosine A2A receptor.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Benzimidazoles; Calcium Channel Agonists; Cations; Cell Movement; Culture Media, Conditioned; Electric Stimulation; Electrophysiology; Histamine; Humans; Immunoglobulin E; Intermediate-Conductance Calcium-Activated Potassium Channels; Lung; Mast Cells; Phenethylamines; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Triazines; Triazoles | 2007 |
Determination of adenosine effects and adenosine receptors in murine corpus cavernosum.
Topics: 2-Chloroadenosine; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Atropine; Bretylium Tosylate; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Penile Erection; Phenylephrine; Prazosin; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Pyrimidines; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptors, Purinergic P1; Triazoles | 2007 |
Combined antagonism of glutamate mGlu5 and adenosine A2A receptors interact to regulate alcohol-seeking in rats.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Alcohol Drinking; Animals; Behavior, Animal; Central Nervous System Depressants; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Ethanol; Extinction, Psychological; Glutamic Acid; Models, Animal; Motor Activity; Pyridines; Pyrimidines; Rats; Rats, Inbred Strains; Reaction Time; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Self Administration; Thiazoles; Time Factors; Triazoles; Xanthines | 2008 |
The role of adenosine A1 and A2A receptors of entorhinal cortex on piriform cortex kindled seizures in rats.
Topics: Adenosine; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Entorhinal Cortex; Kindling, Neurologic; Male; Microinjections; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Seizures; Triazines; Triazoles; Xanthines | 2007 |
Targeted deletion of A2A adenosine receptors attenuates the protective effects of myocardial postconditioning.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Disease Models, Animal; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardial Reperfusion Injury; Myocardium; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, Adenosine A2A; Research Design; Signal Transduction; Time Factors; Triazines; Triazoles; Troponin I; Ventricular Function, Left; Ventricular Pressure | 2007 |
Stimulation of adenosine A2A receptor inhibits LPS-induced expression of intercellular adhesion molecule 1 and production of TNF-alpha in human peripheral blood mononuclear cells.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; CD40 Antigens; Cells, Cultured; Cyclic AMP; Enzyme-Linked Immunosorbent Assay; Flavins; Flow Cytometry; Humans; Intercellular Adhesion Molecule-1; Leukocytes, Mononuclear; Lipopolysaccharide Receptors; Lipopolysaccharides; Receptor, Adenosine A2A; Triazines; Triazoles; Tumor Necrosis Factor-alpha; Xanthines | 2008 |
Anticonvulsant effect of A1 but not A2A adenosine receptors of piriform cortex in amygdala-kindled rats.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Amygdala; Analysis of Variance; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials; Kindling, Neurologic; Male; Microinjections; Models, Anatomic; Phenethylamines; Rats; Rats, Sprague-Dawley; Theophylline; Triazines; Triazoles | 2007 |
Purinergic modulation of glutamate release under ischemic-like conditions in the hippocampus.
Topics: Adenosine; Adenosine Triphosphate; Analgesics; Animals; Dose-Response Relationship, Drug; Glucose; Glutamic Acid; Hippocampus; Hypoxia; In Vitro Techniques; Ischemia; Male; Phenethylamines; Purinergic Agonists; Purinergic Antagonists; Pyrimidines; Rats; Rats, Wistar; Receptors, Purinergic; Sodium Channel Blockers; Tetrodotoxin; Triazines; Triazoles; Xanthines | 2007 |
Interaction of A2A adenosine and D2 dopamine receptors modulates corticostriatal glutamatergic transmission.
Topics: Adenine; Adenosine; Animals; Cerebral Cortex; Corpus Striatum; Dopamine Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Phenethylamines; Quinpirole; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Dopamine D2; Synaptic Transmission; Triazines; Triazoles | 2007 |
Adenosine A2A receptor agonists inhibit lipopolysaccharide-induced production of tumor necrosis factor-alpha by equine monocytes.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; Cyclic AMP; Horses; Immunoenzyme Techniques; Lipopolysaccharides; Monocytes; Phenethylamines; Piperidines; Receptor, Adenosine A2A; Regression Analysis; Triazines; Triazoles; Tumor Necrosis Factor-alpha | 2008 |
Transient inhibition of astrocytogenesis in developing mouse brain following postnatal caffeine exposure.
Topics: Adenosine; Animals; Animals, Newborn; Apoptosis; Astrocytes; Behavior, Animal; Body Weight; Brain; Caffeine; Cell Differentiation; Cell Proliferation; Dose-Response Relationship, Drug; Glial Fibrillary Acidic Protein; Immunohistochemistry; Injections, Intraperitoneal; Mice; Microtubule-Associated Proteins; Models, Animal; Nerve Growth Factors; Organ Size; Phenethylamines; Pyrimidines; Receptor, Adenosine A2A; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Synaptophysin; Time Factors; Triazoles | 2007 |
Adenosine A2A receptors are essential for long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Animals, Newborn; Calcium; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Mossy Fibers, Hippocampal; N-Methylaspartate; Phenethylamines; Pyrimidines; Receptor, Adenosine A2A; Synapses; Triazoles | 2008 |
Involvement of the adenosine A1 and A2A receptors in the antidepressant-like effect of zinc in the forced swimming test.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Aniline Compounds; Animals; Antidepressive Agents; Caffeine; Central Nervous System Stimulants; Dipyridamole; Female; Male; Mice; Motor Activity; Nucleoside Transport Proteins; Receptor, Adenosine A1; Receptor, Adenosine A2A; Swimming; Triazines; Triazoles; Xanthines; Zinc | 2008 |
CNGA2 channels mediate adenosine-induced Ca2+ influx in vascular endothelial cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenylyl Cyclases; Aminoquinolines; Animals; Aorta; Calcium; Cattle; Cells, Cultured; Cyclic Nucleotide-Gated Cation Channels; Endothelial Cells; Enzyme Inhibitors; Imines; Male; Mice; Mice, Inbred C57BL; Patch-Clamp Techniques; Pyrimidines; Receptor, Adenosine A2B; Triazoles | 2008 |
Hypotensive effects of intravenously administered uridine and cytidine in conscious rats: involvement of adenosine receptors.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Animals; Antihypertensive Agents; Blood Pressure; Caffeine; Carotid Arteries; Consciousness; Cytidine; Dose-Response Relationship, Drug; Heart Rate; Hypotension; Injections, Intravenous; Injections, Intraventricular; Male; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Adenosine A2A; Theobromine; Theophylline; Time Factors; Triazines; Triazoles; Uridine; Ventricular Function, Left; Ventricular Pressure; Xanthines | 2008 |
Enhancement of long-term potentiation by brain-derived neurotrophic factor requires adenosine A2A receptor activation by endogenous adenosine.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Data Interpretation, Statistical; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Indole Alkaloids; Isoquinolines; Long-Term Potentiation; Male; Neuroprotective Agents; Phenethylamines; Phosphorylation; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Sulfonamides; Triazoles | 2008 |
Inosine and equilibrative nucleoside transporter 2 contribute to hypoxic preconditioning in the murine cardiomyocyte HL-1 cell line.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A3 Receptor Antagonists; Animals; Cell Hypoxia; Cell Line; Cell Survival; Equilibrative Nucleoside Transporter 1; Equilibrative-Nucleoside Transporter 2; Inosine; Mice; Myocytes, Cardiac; Nucleoside Transport Proteins; Quinazolines; Receptor, Adenosine A1; Receptor, Adenosine A3; Thioinosine; Triazoles; Up-Regulation; Xanthines | 2008 |
Pharmacological blockade of A2A receptors prevents dermal fibrosis in a model of elevated tissue adenosine.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Collagen; Fibrosis; Interleukin-13; Mice; Receptor, Adenosine A2A; Skin; Transforming Growth Factor beta1; Triazines; Triazoles | 2008 |
Design, synthesis, and evaluation of fused heterocyclic analogs of SCH 58261 as adenosine A2A receptor antagonists.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Administration, Oral; Animals; Area Under Curve; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Design; Hydrogen-Ion Concentration; Models, Chemical; Parkinson Disease; Pyrimidines; Rats; Solubility; Triazoles; Water | 2008 |
Adenosine A2A receptor antagonism increases nNOS-immunoreactive neurons in the striatum of Huntington transgenic mice.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Corpus Striatum; Cytoprotection; Disease Models, Animal; Enzyme Activation; Huntington Disease; Interneurons; Male; Mice; Mice, Transgenic; Neuroprotective Agents; Nitrergic Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Pyrimidines; Receptor, Adenosine A2A; Triazoles; Up-Regulation | 2008 |
Human equilibrative nucleoside transporters 1 and 2 may be differentially modulated by A2B adenosine receptors in placenta microvascular endothelial cells from pre-eclampsia.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adult; Endothelial Cells; Equilibrative Nucleoside Transporter 1; Equilibrative-Nucleoside Transporter 2; Female; Gene Expression Regulation; Humans; Phenethylamines; Placenta; Pre-Eclampsia; Pregnancy; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Triazines; Triazoles | 2008 |
Role of CYP epoxygenases in A2A AR-mediated relaxation using A2A AR-null and wild-type mice.
Topics: 8,11,14-Eicosatrienoic Acid; Acetylcholine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Amides; Amidines; Animals; Aorta; Arachidonic Acid; Chromatography, Liquid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indomethacin; Male; Mice; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phenethylamines; Prostaglandin-Endoperoxide Synthases; Pyrimidines; Receptor, Adenosine A2A; Tandem Mass Spectrometry; Triazoles; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2008 |
Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors.
Topics: Adenosine; Adenosine Deaminase; Adult; Animals; Anticonvulsants; Cerebral Cortex; Epilepsy; Female; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Male; Neurons; Oocytes; Purinergic P1 Receptor Antagonists; Pyramidal Tracts; Pyrimidines; Quinazolines; Rats; Receptors, GABA-A; Triazoles; Xanthines; Xenopus | 2008 |
FGF acts as a co-transmitter through adenosine A(2A) receptor to regulate synaptic plasticity.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Cell Differentiation; Cells, Cultured; Chlorocebus aethiops; Cyclic AMP; Embryo, Mammalian; Fibroblast Growth Factors; Hippocampus; Immunoprecipitation; In Vitro Techniques; Long-Term Potentiation; Mitogen-Activated Protein Kinase Kinases; Neurites; Neurons; Patch-Clamp Techniques; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptor, Adenosine A2A; Receptors, Fibroblast Growth Factor; Synapses; Transfection; Triazines; Triazoles; Two-Hybrid System Techniques | 2008 |
Modulation of gamma oscillations by endogenous adenosine through A1 and A2A receptors in the mouse hippocampus.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Biological Clocks; Dose-Response Relationship, Drug; Evoked Potentials; Excitatory Amino Acid Agonists; Fourier Analysis; Hippocampus; Hypoxia; In Vitro Techniques; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Phenethylamines; Receptor, Adenosine A1; Receptor, Adenosine A2A; Theophylline; Thioinosine; Time Factors; Triazines; Triazoles | 2009 |
Inhibition of siderophore biosynthesis by 2-triazole substituted analogues of 5'-O-[N-(salicyl)sulfamoyl]adenosine: antibacterial nucleosides effective against Mycobacterium tuberculosis.
Topics: Adenosine; Animals; Antitubercular Agents; Cell Line, Tumor; Cell Proliferation; Chlorocebus aethiops; Computer Simulation; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Microbial Sensitivity Tests; Models, Chemical; Models, Molecular; Molecular Structure; Mycobacterium tuberculosis; Siderophores; Stereoisomerism; Structure-Activity Relationship; Triazoles; Vero Cells | 2008 |
Adenosine A1 and A2a receptors modulate insulinemia, glycemia, and lactatemia in fetal sheep.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Blood Gas Analysis; Blood Glucose; Female; Fetus; Hydrogen-Ion Concentration; Hypoxia; Insulin; Lactates; Pregnancy; Receptor, Adenosine A1; Receptor, Adenosine A2A; Sheep; Triazines; Triazoles; Xanthines | 2009 |
Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Allopurinol; Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Glutamic Acid; Hot Temperature; Injections, Intraperitoneal; Male; Mice; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pyrimidines; Triazoles; Uric Acid; Xanthine Oxidase; Xanthines | 2009 |
Angiotensin II enhances the afferent arteriolar response to adenosine through increases in cytosolic calcium.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arterioles; Calcium; Cytosol; Kidney; Male; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Naphthyridines; Purines; Receptor, Adenosine A1; Receptor, Angiotensin, Type 1; Receptors, Adenosine A2; Triazines; Triazoles; Vasoconstriction | 2009 |
Adenosine A(1) and A(2A) receptors in mouse prefrontal cortex modulate acetylcholine release and behavioral arousal.
Topics: Acetylcholine; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Arousal; Behavior, Animal; Caffeine; Chromatography, High Pressure Liquid; Electroencephalography; Electromyography; Male; Mice; Microdialysis; Phenethylamines; Phosphodiesterase Inhibitors; Prefrontal Cortex; Receptor, Adenosine A1; Receptors, Adenosine A2; Spectrum Analysis; Triazines; Triazoles; Xanthines | 2009 |
Activation of NTS A2a adenosine receptors differentially resets baroreflex control of renal vs. adrenal sympathetic nerve activity.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adrenal Glands; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Heart Rate; Kidney; Male; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Solitary Nucleus; Sympathetic Nervous System; Theophylline; Triazines; Triazoles | 2009 |
Nitric oxide (NO) does not contribute to the generation or action of adenosine during exercise hyperaemia in rat hindlimb.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Femoral Artery; Hindlimb; Hyperemia; Isometric Contraction; Male; Muscle, Skeletal; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxygen Consumption; Physical Exertion; Rats; Rats, Wistar; Receptor, Adenosine A2A; Regional Blood Flow; S-Nitroso-N-Acetylpenicillamine; Sciatic Nerve; Time Factors; Triazines; Triazoles; Vasodilation | 2009 |
Elucidation in the rat of the role of adenosine and A2A-receptors in the hyperaemia of twitch and tetanic contractions.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Blood Pressure; Carbon Dioxide; Electric Stimulation; Femoral Artery; Hydrogen-Ion Concentration; Hyperemia; Isometric Contraction; Male; Muscle, Skeletal; Muscle, Smooth, Vascular; Oxygen; Rats; Rats, Wistar; Receptor, Adenosine A2A; Regional Blood Flow; Sciatic Nerve; Theophylline; Time Factors; Triazines; Triazoles; Vasodilation | 2009 |
Multiple receptor subtypes and multiple mechanisms of dilation are involved in vascular network dilation caused by adenosine.
Topics: Adenosine; Animals; Arterioles; Cricetinae; Drug Antagonism; Endothelium, Vascular; Flavins; Mesocricetus; Methacholine Chloride; Nitroprusside; Purinergic P1 Receptor Antagonists; Quinazolines; Receptors, Purinergic P1; Triazines; Triazoles; Vasodilation; Vasodilator Agents | 2009 |
Cardioprotection induced by adenosine A1 receptor agonists in a cardiac cell ischemia model involves cooperative activation of adenosine A2A and A2B receptors by endogenous adenosine.
Topics: Acetamides; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Aminopyridines; Animals; Apoptosis; Cardiotonic Agents; Cell Line; Cell Survival; Dihydropyridines; Imidazoles; Myocardial Ischemia; Phenethylamines; Purines; Rats; Triazines; Triazoles; Xanthines | 2009 |
The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slices.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Astrocytes; Blotting, Western; Brain Ischemia; Cell Hypoxia; Cell Survival; Coloring Agents; Excitatory Postsynaptic Potentials; Glial Fibrillary Acidic Protein; Glucose; Hippocampus; Immunohistochemistry; In Vitro Techniques; Male; Neurons; Neuroprotective Agents; Oxygen; Phenethylamines; Propidium; Pyrazoles; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Staining and Labeling; Time Factors; Triazines; Triazoles | 2009 |
Adenosine A1 receptors presynaptically modulate excitatory synaptic input onto subiculum neurons.
Topics: Action Potentials; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Central Nervous System Agents; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Membrane Potentials; Neurons; Presynaptic Terminals; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptors, Adenosine A2; Synapses; Synaptic Transmission; Triazines; Triazoles; Xanthines | 2009 |
Differential regulation of HIF-1alpha isoforms in murine macrophages by TLR4 and adenosine A(2A) receptor agonists.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Cells, Cultured; Drug Combinations; Female; Gene Expression Regulation; Genes, Reporter; Hypoxia-Inducible Factor 1, alpha Subunit; Lipopolysaccharides; Luciferases, Renilla; Macrophages, Peritoneal; Mice; Mice, Congenic; Mice, Inbred C57BL; NF-kappa B; Nitriles; Phenethylamines; Protein Isoforms; Purinergic P1 Receptor Agonists; RNA, Messenger; Sulfones; Toll-Like Receptor 4; Transfection; Triazines; Triazoles; Vascular Endothelial Growth Factor A | 2009 |
SAR of a series of inhaled A(2A) agonists and comparison of inhaled pharmacokinetics in a preclinical model with clinical pharmacokinetic data.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Administration, Inhalation; Adolescent; Adult; Animals; Chemistry, Pharmaceutical; Drug Design; Humans; Inhibitory Concentration 50; Lung; Male; Middle Aged; Models, Chemical; Phenethylamines; Pulmonary Disease, Chronic Obstructive; Purines; Rats; Structure-Activity Relationship; Triazoles | 2009 |
Differential effects of adenosine antagonists in two models of parkinsonian tremor.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Cholinergic Agonists; Disease Models, Animal; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Drug Synergism; Jaw; Male; Parkinsonian Disorders; Pimozide; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Tacrine; Theophylline; Tremor; Triazoles | 2009 |
Altered distribution and function of A2A adenosine receptors in the brain of WAG/Rij rats with genetic absence epilepsy, before and after appearance of the disease.
Topics: Adenosine; Age Factors; Analysis of Variance; Animals; Blotting, Western; Disease Models, Animal; Disease Progression; Electroencephalography; Epilepsy, Absence; Glutamic Acid; Immunohistochemistry; Male; MAP Kinase Signaling System; Microinjections; Phenethylamines; Pyrimidines; Rats; Receptor, Adenosine A2A; Somatosensory Cortex; Thalamus; Triazoles | 2009 |
Absence of adenosine-mediated aortic relaxation in A(2A) adenosine receptor knockout mice.
Topics: Acetylcholine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Aminopyridines; Animals; Aorta; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Flavins; Gene Expression Regulation; In Vitro Techniques; Male; Mice; Mice, Knockout; Phenethylamines; Pyrimidines; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Triazoles; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Xanthines | 2009 |
Adenosine blocks IFN-gamma-induced phosphorylation of STAT1 on serine 727 to reduce macrophage activation.
Topics: Adenosine; Adenosine A3 Receptor Antagonists; Analgesics; Animals; Cell Line; Dihydropyridines; Gene Expression; Humans; Interferon-gamma; Janus Kinases; Macrophage Activation; Macrophages; Mice; Microarray Analysis; Phosphorylation; Quinazolines; Receptor, Adenosine A3; Serine; Signal Transduction; STAT1 Transcription Factor; Transcriptional Activation; Triazoles; Tyrosine | 2009 |
Human follicular lymphoma CD39+-infiltrating T cells contribute to adenosine-mediated T cell hyporesponsiveness.
Topics: Adenosine; Adenosine Triphosphate; Antigens, CD; Apyrase; CD8-Positive T-Lymphocytes; Clonal Anergy; Humans; Interferon-gamma; Interleukin-2; Lymphocytes, Tumor-Infiltrating; Lymphoma, Follicular; Neuroprotective Agents; Pyrimidines; Receptors, Purinergic P1; T-Lymphocytes, Regulatory; Triazines; Triazoles | 2009 |
Role of adenosine A2 receptors in regulation of cerebral blood flow during induced hypotension.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Cerebrovascular Circulation; Dipyridamole; Hypotension; Male; Mice; Mice, Knockout; Phenethylamines; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Triazines; Triazoles; Vasodilation; Vasodilator Agents | 2010 |
Adenosine up-regulates vascular endothelial growth factor in human macrophages.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Angiogenesis Inducing Agents; Cardiotonic Agents; Gene Expression; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Macrophages; Phenethylamines; Pyrimidines; Toll-Like Receptor 4; Triazoles; Up-Regulation; Vascular Endothelial Growth Factor A | 2010 |
Adenosine inhibits paraventricular pre-sympathetic neurons through ATP-dependent potassium channels.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adenosine; Analgesics; Animals; Bicuculline; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glyburide; Guanosine Diphosphate; In Vitro Techniques; KATP Channels; Male; Membrane Potentials; Neurons; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Sodium Channel Blockers; Tetrodotoxin; Thionucleotides; Tolbutamide; Triazines; Triazoles; Xanthines | 2010 |
Polyamidoamine (PAMAM) dendrimer conjugates of "clickable" agonists of the A3 adenosine receptor and coactivation of the P2Y14 receptor by a tethered nucleotide.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Alkynes; Amides; Animals; Catalysis; Cell Line, Tumor; CHO Cells; Copper; Cricetinae; Cricetulus; Dendrimers; Humans; Ligands; Neuroimmunomodulation; Receptors, Purinergic P2; Triazoles; Uridine Diphosphate Glucose | 2010 |
Adenosine A(2)A receptor but not HIF-1 mediates Tyrosine hydroxylase induction in hypoxic PC12 cells.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Cell Hypoxia; Cyclic AMP Response Element-Binding Protein; DNA; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Mutation; PC12 Cells; Phenethylamines; Promoter Regions, Genetic; Rats; Receptor, Adenosine A2A; RNA, Messenger; Signal Transduction; Transcription, Genetic; Transfection; Triazines; Triazoles; Tyrosine 3-Monooxygenase | 2010 |
CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression.
Topics: 5'-Nucleotidase; Adenosine; Adenosine A2 Receptor Antagonists; Animals; Apoptosis; Female; Flow Cytometry; Immunotherapy, Adoptive; Mice; Mice, Inbred C57BL; Mice, Knockout; Ovarian Neoplasms; Pyrimidines; Receptor, Adenosine A2A; RNA, Small Interfering; T-Lymphocytes; Triazoles | 2010 |
Adenosine activates a2b receptors and enhances chloride secretion in kidney inner medullary collecting duct cells.
Topics: Adenosine; Animals; Cell Line; Chlorides; Cystic Fibrosis Transmembrane Conductance Regulator; Kidney Medulla; Kidney Tubules, Collecting; Pyrazoles; Pyrimidines; Rats; Receptor, Adenosine A2B; Triazines; Triazoles; Xanthines | 2010 |
Afferent arteriolar vasodilator effect of adenosine predominantly involves adenosine A2B receptor activation.
Topics: Acetamides; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Arterioles; Dose-Response Relationship, Drug; Kidney; Male; Microcirculation; Microscopy, Video; Perfusion; Purines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Renal Circulation; Triazoles; Vasoconstriction; Vasodilation | 2010 |
Adenosine A(2) receptors modulate tubuloglomerular feedback.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Arterioles; Blood Pressure; Feedback, Physiological; Kidney Glomerulus; Kidney Tubules; Male; Microcirculation; Perfusion; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Renal Circulation; Triazines; Triazoles; Vasoconstriction; Vasodilation; Xanthines | 2010 |
Ecto-5'-nucleotidase (CD73) attenuates allograft airway rejection through adenosine 2A receptor stimulation.
Topics: 5'-Nucleotidase; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Bronchiolitis Obliterans; CD3 Complex; Chromatography, Liquid; Gene Expression; Graft Rejection; Interferon-gamma; Interleukin-2; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenethylamines; Pyrimidines; Receptor, Adenosine A2A; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Tandem Mass Spectrometry; Trachea; Transplantation, Homologous; Triazoles | 2010 |
Expeditious synthesis and biological evaluation of new C-6 1,2,3-triazole adenosine derivatives A1 receptor antagonists or agonists.
Topics: Adenosine; Animals; Cell Line; Cyclic AMP; Humans; Molecular Structure; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Triazoles | 2010 |
Activation of adenosine A2A receptor attenuates inflammatory response in a rat model of small-for-size liver transplantation.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Alanine Transaminase; Animals; Chemokine CXCL2; Cytokines; Enzyme-Linked Immunosorbent Assay; Inflammation; Intercellular Adhesion Molecule-1; Liver; Liver Transplantation; Male; NF-kappa B; Organ Size; Peroxidase; Phenethylamines; Phosphorylation; Rats; Rats, Inbred Lew; Receptor, Adenosine A2A; Triazines; Triazoles; Tumor Necrosis Factor-alpha | 2010 |
Peripheral adenosine A2A receptors are involved in carrageenan-induced mechanical hyperalgesia in mice.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Carrageenan; Female; Ganglia, Spinal; Hyperalgesia; Inflammation; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Mice, Knockout; Pain; Pain Threshold; Phenethylamines; Receptor, Adenosine A2A; Sex Characteristics; Triazines; Triazoles | 2010 |
Novel 8-(furan-2-yl)-3-benzyl thiazolo [5,4-e][1,2,4] triazolo [1,5-c] pyrimidine-2(3H)-thione as selective adenosine A(2A) receptor antagonist.
Topics: Acridines; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Cell Line, Transformed; Chloroquinolinols; Corpus Striatum; Cyclic AMP; Dopamine Antagonists; Dose-Response Relationship, Drug; Humans; Mice; Models, Molecular; Phenethylamines; Protein Binding; Pyrimidines; Receptors, Adenosine A2; Time Factors; Triazoles; Tritium | 2011 |
Cooperative cardioprotection through adenosine A1 and A2A receptor agonism in ischemia-reperfused isolated mouse heart.
Topics: Acetamides; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Blood Pressure; Cardiotonic Agents; Drug Synergism; In Vitro Techniques; Male; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardial Contraction; Myocardial Reperfusion Injury; Phosphorylation; Purines; Receptor, Adenosine A2A; Triazines; Triazoles; Xanthines | 2010 |
Contribution of adenosine A(2A) and A(2B) receptors to ischemic coronary dilation: role of K(V) and K(ATP) channels.
Topics: 4-Aminopyridine; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Coronary Circulation; Disease Models, Animal; Dogs; Flavins; Glyburide; Hyperemia; KATP Channels; Male; Myocardial Ischemia; Phenethylamines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pyrimidines; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Triazoles; Vasodilation | 2010 |
Static magnetic field exposure reproduces cellular effects of the Parkinson's disease drug candidate ZM241385.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine Triphosphate; Analysis of Variance; Animals; Blotting, Western; Calcium; Cell Proliferation; Cyclic AMP; Iron; Magnetic Field Therapy; Magnetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurites; Parkinson Disease; PC12 Cells; Phenethylamines; Phosphorylation; Rats; Receptor, Adenosine A2A; Triazines; Triazoles | 2010 |
Structure of an agonist-bound human A2A adenosine receptor.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Binding Sites; Crystallography, X-Ray; Humans; Hydrogen Bonding; Ligands; Models, Molecular; Opsins; Protein Conformation; Protein Structure, Secondary; Receptor, Adenosine A2A; Rhodopsin; Triazines; Triazoles | 2011 |
Selective adenosine A2A receptor agonists and antagonists protect against spinal cord injury through peripheral and central effects.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Inflammation; Infusion Pumps, Implantable; JNK Mitogen-Activated Protein Kinases; Male; Mice; Motor Activity; Phenethylamines; Pyrimidines; Spinal Cord; Spinal Cord Injuries; Triazoles | 2011 |
Adenosine A(2A) receptor activation prevents progressive kidney fibrosis in a model of immune-associated chronic inflammation.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Anti-Inflammatory Agents; Autoantibodies; Disease Models, Animal; Extracellular Matrix Proteins; Fibrosis; Glomerulonephritis; Inflammation Mediators; Kidney; Macrophages; Male; Phenethylamines; Rats; Rats, Inbred WKY; Receptor, Adenosine A2A; Severity of Illness Index; Time Factors; Triazines; Triazoles | 2011 |
Adenosine A2(A) receptor modulates the oxidative stress response of primed polymorphonuclear leukocytes after parabolic flight.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Adult; Gene Expression Regulation; Gravity, Altered; Humans; Hydrogen Peroxide; Immunologic Factors; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidative Stress; Receptors, Adenosine A2; RNA, Messenger; Triazines; Triazoles; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2011 |
Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Crystallography, X-Ray; Drug Inverse Agonism; Humans; Ligands; Models, Molecular; Molecular Conformation; Receptor, Adenosine A2A; Triazines; Triazoles | 2011 |
Enhanced role of adenosine A(2A) receptors in the modulation of LTP in the rat hippocampus upon ageing.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Aging; Animals; Electrophysiology; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Long-Term Potentiation; Male; Memory Disorders; N-Methylaspartate; Neuronal Plasticity; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Adenosine A2A; Synaptic Transmission; Triazoles; Xanthines | 2011 |
The effect of A(2A) adenosine receptor activation on C-C chemokine receptor 7 expression in human THP1 macrophages during inflammation.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Cell Line; Cell Movement; Chemokine CCL21; Humans; Inflammation; Macrophages; Phenethylamines; Receptors, Adenosine A2; Receptors, CCR7; RNA, Messenger; Triazines; Triazoles | 2012 |
Differential neuroprotection by A(1) receptor activation and A(2A) receptor inhibition following pilocarpine-induced status epilepticus.
Topics: Adenosine; Analysis of Variance; Animals; Brain; Cell Count; Disease Models, Animal; Drug Interactions; Fluoresceins; Male; Nerve Degeneration; Neuroprotective Agents; Organic Chemicals; Phenylisopropyladenosine; Pilocarpine; Pyrimidines; Rats; Rats, Wistar; Reaction Time; Receptor, Adenosine A1; Receptor, Adenosine A2A; Status Epilepticus; Triazoles | 2011 |
[Sedative, hypnotic and anticonvulsive effects of an adenosine analogue WS090501].
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Anticonvulsants; Convulsants; Electroencephalography; Hypnotics and Sedatives; Male; Mice; Mice, Inbred ICR; Motor Activity; Pentylenetetrazole; Pyrimidines; Rats; Rats, Wistar; Seizures; Sleep; Triazoles; Xanthines | 2011 |
Distinctive immunoregulatory effects of adenosine on T cells of older humans.
Topics: Adenine; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adult; Age Factors; Aged; Aged, 80 and over; Antigens, CD; Apyrase; CD28 Antigens; Cells, Cultured; Chemotaxis; Cytokines; Dose-Response Relationship, Drug; Female; Flow Cytometry; Humans; Male; Middle Aged; Phenethylamines; Pyrimidines; T-Lymphocytes; Triazoles; Young Adult | 2012 |
The effect of adenosine on pro-inflammatory cytokine production by porcine T cells.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; CD3 Complex; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Concanavalin A; Dose-Response Relationship, Drug; Flow Cytometry; Inflammation; Interferon-gamma; Interleukin-10; Interleukin-2; Quinazolines; Swine; T-Lymphocyte Subsets; T-Lymphocytes; Triazoles; Tumor Necrosis Factor-alpha | 2012 |
[Protective effect of new adenosine analog B2 against serum deprivation-induced PC12 cell injury].
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Cell Survival; Corpus Striatum; Culture Media, Serum-Free; Female; Male; PC12 Cells; Pyrimidines; Rats; Rats, Wistar; Reactive Oxygen Species; Receptor, Adenosine A2A; Triazoles | 2011 |
[1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding.
Topics: Adenosine; Binding Sites; Crystallography, X-Ray; HEK293 Cells; Humans; Models, Molecular; Oxadiazoles; Protein Conformation; Structure-Activity Relationship; Sulfides; Tankyrases; Triazoles; Wnt Signaling Pathway | 2012 |
Characterization of the Drosophila adenosine receptor: the effect of adenosine analogs on cAMP signaling in Drosophila cells and their utility for in vivo experiments.
Topics: 2-Chloroadenosine; Adenosine; Amino Acid Sequence; Amino Acids; Animals; Calcium; Calcium Signaling; Cell Line; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Drosophila; Humans; Molecular Sequence Data; Pyrimidines; Real-Time Polymerase Chain Reaction; Receptors, Purinergic P1; Signal Transduction; Survival; Triazoles | 2012 |
The adenosine 2A receptor agonist GW328267C improves lung function after acute lung injury in rats.
Topics: Acute Lung Injury; Adenosine; Amiloride; Animals; Biological Transport; Bronchoalveolar Lavage; Cystic Fibrosis Transmembrane Conductance Regulator; Endotoxemia; Epithelial Sodium Channel Blockers; Epithelial Sodium Channels; Escherichia coli; Escherichia coli Infections; Immunoblotting; Male; Pneumonia; Pulmonary Alveoli; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Respiratory Physiological Phenomena; Sodium Channel Blockers; Triazoles | 2012 |
A novel dihydro-pyrazolo(3,4d)(1,2,4)triazolo(1,5a)pyrimidin-4-one (AJ23) is an antagonist at adenosine A(1) receptors and enhances consolidation of step-down avoidance.
Topics: Adenosine; Analysis of Variance; Animals; Avoidance Learning; CA1 Region, Hippocampal; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Electric Stimulation; Excitatory Postsynaptic Potentials; HEK293 Cells; Heterocyclic Compounds, 3-Ring; Humans; In Vitro Techniques; Inhibition, Psychological; Male; Protein Binding; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Wistar; Reaction Time; Retention, Psychology; Structure-Activity Relationship; Triazines; Triazoles; Tritium; Xanthines | 2012 |
The mechanism of beta-adrenergic preconditioning: roles for adenosine and ROS during triggering and mediation.
Topics: Adenosine; Animals; Ethanolamines; Extracellular Signal-Regulated MAP Kinases; Formoterol Fumarate; Ischemic Preconditioning, Myocardial; Isoproterenol; Myocardial Infarction; Phosphatidylinositol 3-Kinases; Potassium Channels; Protein Kinase C; Proto-Oncogene Proteins c-akt; Rats; Reactive Oxygen Species; Receptors, Adrenergic, beta; Receptors, Purinergic P1; Triazines; Triazoles | 2012 |
Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase-null mice through CYP-epoxygenases and PPARγ.
Topics: 8,11,14-Eicosatrienoic Acid; Adamantane; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Benzamides; Benzoates; Butyrates; Enzyme Inhibitors; Epoxide Hydrolases; Female; Gene Silencing; Lauric Acids; Male; Mice; NG-Nitroarginine Methyl Ester; Oxygenases; Phenethylamines; Phenylurea Compounds; PPAR gamma; Pyridines; Pyrimidines; Receptor, Adenosine A2A; Triazines; Triazoles; Urea; Vasodilation; Vasodilator Agents | 2013 |
High-intensity swimming exercise reduces neuropathic pain in an animal model of complex regional pain syndrome type I: evidence for a role of the adenosinergic system.
Topics: Adenine; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine Deaminase Inhibitors; Animals; Caffeine; Exercise Therapy; Hyperalgesia; Male; Mice; Naloxone; Narcotic Antagonists; Neuralgia; Neurons; Reflex Sympathetic Dystrophy; Swimming; Triazines; Triazoles; Xanthines | 2013 |
Adenosine 2A receptor modulates inflammation and phenotype in experimental abdominal aortic aneurysms.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Aortic Aneurysm, Abdominal; CD4-Positive T-Lymphocytes; Cytokines; Humans; Inflammation; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Pancreatic Elastase; Phenethylamines; Phenotype; Receptors, Adenosine A2; Triazines; Triazoles | 2013 |
Role of adenosine A2A receptor in organ-specific vascular reactivity following hemorrhagic shock in rats.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Aorta, Thoracic; Female; Femoral Artery; Hemodynamics; Male; Mesenteric Artery, Superior; Middle Cerebral Artery; Models, Animal; Phenethylamines; Pulmonary Artery; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Renal Artery; Shock, Hemorrhagic; Survival Rate; Triazoles | 2013 |
Adenosine A(2A) receptors regulate the activity of sleep regulatory GABAergic neurons in the preoptic hypothalamus.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; GABAergic Neurons; Hypothalamus; Infusions, Intraventricular; Male; Microinjections; Models, Animal; Phenethylamines; Preoptic Area; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Sleep; Triazines; Triazoles | 2013 |
Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Corpus Striatum; Dopamine; Gene Expression Regulation; Male; Motor Skills; Nicotine; Phenethylamines; Presynaptic Terminals; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Nicotinic; Synaptosomes; Triazines; Triazoles | 2013 |
Adenosine A₂A receptors inhibit delayed rectifier potassium currents and cell differentiation in primary purified oligodendrocyte cultures.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Cell Differentiation; Cell Proliferation; Delayed Rectifier Potassium Channels; Dose-Response Relationship, Drug; Electric Conductivity; Membrane Potentials; Neural Inhibition; Oligodendroglia; Phenethylamines; Potassium; Primary Cell Culture; Pyrimidines; Rats; Receptor, Adenosine A2A; Stem Cells; Triazoles | 2013 |
Ecto-5'-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions.
Topics: 5'-Nucleotidase; Adenosine; Adenosine A2 Receptor Antagonists; Animals; Corpus Striatum; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyrimidines; Receptor, Adenosine A2A; Triazoles | 2013 |
Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Animals, Newborn; Blood Flow Velocity; Cerebrovascular Circulation; Corpus Striatum; Disease Models, Animal; Hypoxia-Ischemia, Brain; Immunohistochemistry; Laser-Doppler Flowmetry; Male; Neurons; Oxidative Stress; Phenethylamines; Pyrimidines; Receptor, Adenosine A2A; Sus scrofa; Triazoles | 2013 |
The stimulation of adenosine A2A receptors ameliorates the pathological phenotype of fibroblasts from Niemann-Pick type C patients.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Calcium; Case-Control Studies; Cell Line; Cholesterol; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electron Transport Complex IV; Extracellular Signal-Regulated MAP Kinases; Female; Fibroblasts; Humans; Lysosomes; Male; Membrane Potential, Mitochondrial; Mitochondria; Niemann-Pick Disease, Type C; Phenethylamines; Phenotype; Receptor, Adenosine A2A; Triazines; Triazoles | 2013 |
Nucleus tractus solitarii A(2a) adenosine receptors inhibit cardiopulmonary chemoreflex control of sympathetic outputs.
Topics: Adenosine; Adrenal Glands; Animals; Biguanides; Blood Pressure; Chemoreceptor Cells; Heart Atria; Heart Conduction System; Heart Rate; Hypotension; Kidney; Lumbosacral Region; Male; Microinjections; Models, Neurological; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Reflex; Serotonin 5-HT3 Receptor Agonists; Solitary Nucleus; Sympathetic Nervous System; Triazines; Triazoles | 2014 |
Selective inhibition of KCa3.1 channels mediates adenosine regulation of the motility of human T cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Calcium; Calcium Channel Blockers; Cell Movement; Cells, Cultured; Cyclic AMP-Dependent Protein Kinase Type I; Female; Humans; Immunologic Surveillance; Intercellular Adhesion Molecule-1; Interleukin-2; Intermediate-Conductance Calcium-Activated Potassium Channels; Ion Transport; Kv1.3 Potassium Channel; Lymphocyte Activation; Male; Patch-Clamp Techniques; Phenethylamines; Protein Serine-Threonine Kinases; Pyrazoles; Pyrimidines; Receptor, Adenosine A2A; T-Lymphocytes; Triazoles; TRPM Cation Channels | 2013 |
Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-α2 controlling glutamate uptake in astrocytes.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Aspartic Acid; Astrocytes; Glial Fibrillary Acidic Protein; Glutamic Acid; Immunoprecipitation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Ouabain; Phenethylamines; Pyrimidines; Receptor, Adenosine A2A; Sodium-Potassium-Exchanging ATPase; Subcellular Fractions; Triazoles; Tritium | 2013 |
Mechanisms involved in increased sensitivity to adenosine A(2A) receptor activation and hypoxia-induced vasodilatation in porcine coronary arteries.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Coronary Vessels; Cyclic AMP; Dinoprost; HSP20 Heat-Shock Proteins; Hypoxia; In Vitro Techniques; Oxygen; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Swine; Triazines; Triazoles; Vasodilation | 2014 |
Adenosine A(2A) Receptors as novel upstream regulators of BDNF-mediated attenuation of hippocampal Long-Term Depression (LTD).
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine Deaminase; Adenylyl Cyclases; Animals; Brain-Derived Neurotrophic Factor; CA1 Region, Hippocampal; Cyclic AMP-Dependent Protein Kinases; Electric Stimulation; Enzyme Inhibitors; Extracellular Space; In Vitro Techniques; Long-Term Synaptic Depression; Phenethylamines; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptor, trkB; Triazoles | 2014 |
Extracellular adenosine controls NKT-cell-dependent hepatitis induction.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Cells, Cultured; Concanavalin A; Flow Cytometry; Galactosylceramides; Hepatitis, Animal; Interferon-gamma; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Natural Killer T-Cells; Phenethylamines; Receptor, Adenosine A2A; Triazines; Triazoles; Tumor Necrosis Factor-alpha | 2014 |
Histamine H3 receptor activation counteracts adenosine A2A receptor-mediated enhancement of depolarization-evoked [3H]-GABA release from rat globus pallidus synaptosomes.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Biphenyl Compounds; gamma-Aminobutyric Acid; Globus Pallidus; Histamine Agonists; Histamine H3 Antagonists; Imidazoles; Male; Membrane Potentials; Nitriles; Phenethylamines; Piperidines; Potassium; Pyrrolidines; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Histamine H3; Synaptosomes; Thiourea; Triazines; Triazoles; Tritium | 2014 |
Chronic treatment with ticagrelor limits myocardial infarct size: an adenosine and cyclooxygenase-2-dependent effect.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Aspirin; Cardiotonic Agents; Clopidogrel; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Evaluation, Preclinical; Enzyme Induction; Lipoxins; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Nitric Oxide Synthase Type III; Pyrazoles; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Ticagrelor; Ticlopidine; Triazoles; Up-Regulation | 2014 |
On the role of adenosine (A)₂A receptors in cocaine-induced reward: a pharmacological and neurochemical analysis in rats.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Basal Forebrain; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Male; Nucleus Accumbens; Phenethylamines; Purines; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Reinforcement, Psychology; Reward; Self Administration; Triazoles | 2015 |
Metabolic hyperemia requires ATP-sensitive K+ channels and H2O2 but not adenosine in isolated mouse hearts.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Coronary Circulation; Free Radical Scavengers; Glyburide; Heart; Hydrogen Peroxide; Hyperemia; In Vitro Techniques; KATP Channels; Mice; Mice, Inbred C57BL; Myocardial Contraction; Myocardium; NG-Nitroarginine Methyl Ester; Potassium Channel Blockers; Pyrimidines; Receptors, Purinergic P1; Theophylline; Triazoles | 2014 |
WS0701: a novel sedative-hypnotic agent acting on the adenosine system.
Topics: Adenosine; Animals; Behavior, Animal; Decanoates; Frontal Lobe; Hypnotics and Sedatives; Hypothalamus; Male; Maze Learning; Mice; Phenobarbital; Picrotoxin; Pyrimidines; Rats; Rats, Sprague-Dawley; Sleep Stages; Time Factors; Triazoles | 2014 |
Sitagliptin attenuates sympathetic innervation via modulating reactive oxygen species and interstitial adenosine in infarcted rat hearts.
Topics: Adenosine; Animals; Heart; Male; Myocardial Infarction; Pyrazines; Rats; Rats, Wistar; Reactive Oxygen Species; Sitagliptin Phosphate; Triazoles | 2015 |
Expression of CD73 and A2A receptors in cells from subjects with obesity and type 2 diabetes mellitus.
Topics: 5'-Nucleotidase; Adenosine; Adult; Antigens, CD; Apoptosis; Apyrase; Body Mass Index; CD8-Positive T-Lymphocytes; Diabetes Mellitus, Type 2; Gene Expression Regulation; GPI-Linked Proteins; Humans; Inflammation; Lymphocyte Subsets; Lymphocytes; Obesity; Phenethylamines; Receptor, Adenosine A2A; Triazines; Triazoles | 2015 |
Different danger signals differently impact on microglial proliferation through alterations of ATP release and extracellular metabolism.
Topics: 5'-Nucleotidase; Adenosine; Adenosine A2 Receptor Antagonists; Adenosine Deaminase; Adenosine Diphosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Apyrase; Cell Line; Cell Proliferation; Cells, Cultured; Enzyme Inhibitors; Extracellular Space; Glutamic Acid; Lipopolysaccharides; Mice, Inbred C57BL; Microglia; Pyrimidines; Receptors, Adenosine A2; Triazoles | 2015 |
Triazolophostins: a library of novel and potent agonists of IP3 receptors.
Topics: Adenosine; Animals; Calcium; Cell Line; Chickens; Humans; Inositol 1,4,5-Trisphosphate Receptors; Molecular Docking Simulation; Small Molecule Libraries; Structure-Activity Relationship; Triazoles | 2015 |
Adenosine A(2A) receptors are necessary and sufficient to trigger memory impairment in adult mice.
Topics: Adenosine; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Infusions, Intraventricular; Locomotion; Male; Maze Learning; Memory Disorders; Memory, Short-Term; Mice; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Receptor, Adenosine A1; Receptor, Adenosine A2A; Recognition, Psychology; Scopolamine; Triazoles; Xanthines | 2015 |
Potent, Metabolically Stable 2-Alkyl-8-(2H-1,2,3-triazol-2-yl)-9H-adenines as Adenosine A2A Receptor Ligands.
Topics: Adenosine; Dose-Response Relationship, Drug; Humans; Ligands; Microsomes, Liver; Molecular Structure; Receptor, Adenosine A2A; Structure-Activity Relationship; Triazoles | 2015 |
Effect of adenosine system in the action of oseltamivir on behavior in mice.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Antiviral Agents; Behavior, Animal; Caffeine; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Neuraminidase; Oseltamivir; Phenethylamines; Pyrimidines; Receptors, Adenosine A2; Triazoles; Walking | 2015 |
Evaluation of the expression and function of the P2X7 receptor and ART1 in human regulatory T-cell subsets.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine Triphosphate; Adolescent; ADP Ribose Transferases; Adult; Antigens, CD; Apyrase; Cell Death; Cell Proliferation; Female; Gene Expression Regulation; GPI-Linked Proteins; Humans; Immunophenotyping; L-Selectin; Male; NAD; Phenethylamines; Primary Cell Culture; Receptors, Adenosine A2; Receptors, Purinergic P2X7; Signal Transduction; T-Lymphocyte Subsets; Triazines; Triazoles | 2016 |
Adenosine A2A receptor activation is determinant for BDNF actions upon GABA and glutamate release from rat hippocampal synaptosomes.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Brain-Derived Neurotrophic Factor; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Phenethylamines; Potassium; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Synaptosomes; Triazoles | 2015 |
[Central-adenosine A1 receptor involved in the thermal regulation effect of YZG-330, a N6-substituted adenosine derivative, in mice].
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Body Temperature Regulation; Mice; Pyrimidines; Receptor, Adenosine A1; Triazoles; Xanthines | 2015 |
Mechanisms of the adenosine A2A receptor-induced sensitization of esophageal C fibers.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Dose-Response Relationship, Drug; Esophagus; Guinea Pigs; In Vitro Techniques; Isoquinolines; Muscle Contraction; Nerve Endings; Nerve Fibers, Unmyelinated; Neuroprotective Agents; Nodose Ganglion; Patch-Clamp Techniques; Phenethylamines; Protein Kinase Inhibitors; Purinergic P2X Receptor Agonists; Pyrimidines; Receptor, Adenosine A2A; Sulfonamides; Transient Receptor Potential Channels; Triazoles; Vagus Nerve | 2016 |
Paracrine effect of carbon monoxide - astrocytes promote neuroprotection through purinergic signaling in mice.
Topics: Adenosine; Adenosine Triphosphate; Animals; Apoptosis; Astrocytes; Carbon Monoxide; Coculture Techniques; Cysteine; Extracellular Space; Gene Silencing; Glycyrrhetinic Acid; Mice, Inbred C57BL; Models, Biological; Neurons; Neuroprotection; Paracrine Communication; Pyrimidines; Receptor, trkB; Receptors, Adenosine A2; Receptors, Purinergic; Serine; Signal Transduction; Suramin; Thioinosine; Triazoles; Xanthines | 2016 |
Adenosine A
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Dependovirus; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; Luminescent Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Inhibition; Olfactory Bulb; Patch-Clamp Techniques; Phenethylamines; Proto-Oncogene Proteins c-fos; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; RNA, Small Interfering; Sleep, REM; Transduction, Genetic; Triazoles | 2017 |
Equilibrative nucleoside transporter ENT1 as a biomarker of Huntington disease.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Biomarkers; Corpus Striatum; Disease Models, Animal; Gene Expression Regulation; Humans; Huntingtin Protein; Huntington Disease; Locomotion; Nucleoside Transport Proteins; Prefrontal Cortex; Psychomotor Disorders; Purines; Rats; Rats, Transgenic; Receptor, Adenosine A2A; Triazines; Triazoles; Trinucleotide Repeat Expansion; Tritium | 2016 |
Adenosine A
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adult; Aged; Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Disease Models, Animal; Female; Glycogen Synthase Kinase 3 beta; Glycogen Synthase Kinases; Hippocampus; Humans; Indoles; Isoquinolines; Male; Maleimides; Mice; Mice, Knockout; Middle Aged; Neurons; Phenethylamines; Phosphorylation; Protein Kinase Inhibitors; Receptor, Adenosine A2A; Signal Transduction; Sulfonamides; tau Proteins; Triazines; Triazoles | 2017 |
Theacrine: A purine alkaloid from Camellia assamica var. kucha with a hypnotic property via the adenosine system.
Topics: Adenosine; Alkaloids; Animals; Caffeine; Camellia; Drug Synergism; Hippocampus; Male; Mice; Pentobarbital; Pyrimidines; Rats; Sleep Initiation and Maintenance Disorders; Sleep Stages; Triazoles; Uric Acid; Xanthines | 2017 |
Nucleus accumbens mediates the pronociceptive effect of sleep deprivation: the role of adenosine A2A and dopamine D2 receptors.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Male; Motor Activity; Nociception; Nucleus Accumbens; Pain; Phenethylamines; Piribedil; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Dopamine D2; Sleep Deprivation; Sleep, REM; Triazoles | 2018 |
Synthesis and cytotoxic activity of novel acyclic nucleoside analogues with functionality in click chemistry.
Topics: Acids, Acyclic; Adenosine; Alkynes; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Click Chemistry; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Spectrometry, Mass, Electrospray Ionization; Thymidine; Triazoles | 2018 |
Mechanistic insights into allosteric regulation of the A
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Allosteric Regulation; Amino Acid Sequence; Animals; Binding Sites; Calcium; Cations, Divalent; Crystallography, X-Ray; Gene Expression; Humans; Kinetics; Magnesium; Models, Molecular; Molecular Dynamics Simulation; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Receptor, Adenosine A2A; Recombinant Proteins; Sf9 Cells; Spodoptera; Thermodynamics; Triazines; Triazoles | 2018 |
Cystatin F involvement in adenosine A
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Cell Hypoxia; Cell Line; Cell Survival; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Cystatins; Cytokines; Gene Knockdown Techniques; MAP Kinase Signaling System; Mice; Microglia; Phenethylamines; Protein Kinase C; Pyrimidines; Receptor, Adenosine A2A; RNA, Small Interfering; Signal Transduction; Transfection; Triazoles | 2018 |
Cervical cancer cells produce TGF-β1 through the CD73-adenosine pathway and maintain CD73 expression through the autocrine activity of TGF-β1.
Topics: 5'-Nucleotidase; Acetamides; Adenosine; Adenosine A2 Receptor Antagonists; Autocrine Communication; Cell Line, Tumor; Female; GPI-Linked Proteins; HeLa Cells; Humans; Immunosuppression Therapy; Purines; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Transforming Growth Factor beta1; Triazines; Triazoles; Tumor Microenvironment; Uterine Cervical Neoplasms | 2019 |
Ischemia postconditioning protects dermal microvascular endothelial cells of rabbit epigastric skin flaps against apoptosis via adenosine A2a receptors.
Topics: Abdomen; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Apoptosis; Dermis; Endothelial Cells; Ischemic Postconditioning; Models, Animal; Phenethylamines; Rabbits; Surgical Flaps; Triazines; Triazoles | 2019 |
Time-Dependent Bidirectional Neuroprotection by Adenosine 2A Receptor in Experimental Traumatic Brain Injury.
Topics: Adenosine; Animals; Brain Injuries; Brain Injuries, Traumatic; Disease Models, Animal; Male; Neuroprotection; Neuroprotective Agents; Phenethylamines; Pyrimidines; Rats, Wistar; Receptors, Purinergic P1; Signal Transduction; Time Factors; Triazoles | 2019 |
Activation of adenosine A2a receptor accelerates and A2a receptor antagonist reduces intermittent hypoxia induced PC12 cell injury via PKC-KATP pathway.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine Triphosphate; Animals; Cell Hypoxia; KATP Channels; PC12 Cells; Phenethylamines; Potassium Channels; Protein Kinase C; Pyrimidines; Random Allocation; Rats; Receptor, Adenosine A2A; Signal Transduction; Sulfonylurea Receptors; Triazoles | 2019 |
Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A
Topics: 5'-Nucleotidase; Adenosine; Adenosine A2 Receptor Antagonists; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Line, Tumor; Humans; Male; Oxidopamine; Parkinsonian Disorders; Pyrimidines; Rats, Wistar; Receptor, Adenosine A2A; Triazoles | 2019 |
HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N
Topics: 5' Untranslated Regions; Adenosine; Cell Line, Tumor; Genes, Reporter; Heat-Shock Proteins; HSP40 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Methylation; Proteomics; RNA, Messenger; Triazoles | 2019 |
Contribution of adenosine and ATP to the carotid body chemosensory activity in ageing.
Topics: Adenosine; Adenosine Triphosphate; Aging; Animals; Antinematodal Agents; Carotid Body; Chemoreceptor Cells; Female; Gene Expression Regulation; Male; Rats; Rats, Wistar; Suramin; Triazines; Triazoles | 2019 |
Caffeine Exacerbates Postictal Hypoxia.
Topics: Adenosine; Animals; CA1 Region, Hippocampal; Caffeine; Dose-Response Relationship, Drug; Hypoxia; Kindling, Neurologic; Male; Oxygen; Phenethylamines; Pyrimidines; Rats; Receptors, Adenosine A2; Seizures; Triazoles | 2019 |
Adenosine Receptors as Neuroinflammation Modulators: Role of A
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Cells, Cultured; Inflammation; Male; Neuroglia; Neurons; Rats, Wistar; Receptors, Purinergic P1; Triazines; Triazoles | 2020 |
Synthesis of Triazole-Linked SAM-Adenosine Conjugates: Functionalization of Adenosine at N-1 or N-6 Position without Protecting Groups.
Topics: Adenosine; Humans; Methylation; Methyltransferases; RNA Processing, Post-Transcriptional; RNA, Messenger; S-Adenosylmethionine; Triazoles | 2020 |
Single Stabilizing Point Mutation Enables High-Resolution Co-Crystal Structures of the Adenosine A
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Humans; Point Mutation; Pyrimidines; Receptor, Adenosine A2A; Triazoles | 2022 |
Synthesis and Activity of Triazole-Adenosine Analogs as Protein Arginine Methyltransferase 5 Inhibitors.
Topics: Adenosine; Arginine; Cell Line, Tumor; Enzyme Inhibitors; Molecular Docking Simulation; Protein-Arginine N-Methyltransferases; S-Adenosylmethionine; Triazoles | 2022 |