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triazoles and ravuconazole

triazoles has been researched along with ravuconazole in 101 studies

Research

Studies (101)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (9.90)18.2507
2000's51 (50.50)29.6817
2010's24 (23.76)24.3611
2020's16 (15.84)2.80

Authors

AuthorsStudies
Hata, K; Katsu, K; Kimura, J; Miki, H; Nakamura, T; Toyosawa, T1
Hata, K; Katsu, K; Kimura, J; Miki, H; Moriyama, M; Toyosawa, T1
Bonner, DP; Fung-Tomc, JC; Huczko, E; Minassian, B1
Kakinuma, H; Kaku, Y; Naito, T; Nara, K; Tsukada, I; Tsuruoka, A; Yanagisawa, M1
Brandt, ME; Doern, GV; Hajjeh, RA; Hollis, RJ; Jones, RN; Messer, SA; Pfaller, MA1
Coleman, DC; Gee, S; Joly, S; Messer, SA; Pfaller, MA; Pujol, C; Soll, DR; Sullivan, DJ1
Matsushima, T; Nakajima, M; Niki, Y1
Diekema, DJ; Doern, GV; Hollis, RJ; Houston, A; Jones, RN; Messer, SA; Pfaller, MA1
Bonner, DP; Fung-Tomc, JC; Huczko, E; Minassian, B; White, TC1
Denning, DW; Moore, CB; Walls, CM1
Hollis, RJ; Houston, A; Jones, RN; Messer, SA; Pfaller, MA; Yamazumi, T1
Andriole, VT; Marino, S; Roberts, J; Schock, K1
Carrillo, AJ; Guarro, J1
Diekema, DJ; Fluit, AC; Hollis, RJ; Jones, RN; Messer, SA; Pfaller, MA; Sader, HS1
Clemons, KV; Stevens, DA1
Coco, BJ; Kirkpatrick, WR; Patterson, TF; Perea, S1
Calderon, L; Clemons, KV; Martinez, M; Stevens, DA1
Hollis, RJ; Jones, RN; Messer, SA; Pfaller, MA1
Fukayama, N; Hayasaki, Y; Mikamo, H; Satoh, M; Shimamura, Y; Tamaya, T; Uesugi, K; Yin, XH1
Boyken, L; Diekema, DJ; Hollis, RJ; Huynh, H; Messer, SA; Pfaller, MA1
Diekema, DJ; Hollis, RJ; Jones, RN; Messer, SA; Pfaller, MA2
Arikan, S; Rex, JH1
Habel, F; Hoban, D; Laverdiere, M; Restieri, C1
Ichihara, S; Murasaki, C; Ohwada, J; Shimma, N; Umeda, I; Yamazaki, T1
Lira, R; Payares, G; Romanha, AJ; Sanoja, C; Urbina, JA1
Andes, D; Conklin, R; Marchillo, K; Stamstad, T1
Kamei, K1
Avila, NA; Bacher, J; Casler, HE; Groll, AH; Kelaher, AM; Lyman, CA; Petraitiene, R; Petraitis, V; Sarafandi, AA; Sein, T; Walsh, TJ1
Sutton, DA1
Gupta, AK; Tomas, E1
Capilla, J; Guarro, J; Ortoneda, M; Pastor, FJ; Rinaldi, MG; Serena, C; Sutton, DA1
Barbour, N; Bronson, JJ; Chen, CP; Clark, J; Connolly, TP; Dali, M; Gao, Q; Golik, J; Huang, S; Hudyma, TW; Kang, SH; Knipe, J; Lamb, L; Mathew, M; Matiskella, JD; Medin, I; Mosure, K; Tejwani, R; Ueda, Y; Varia, S; Venkatesh, S; Zheng, M1
Bonner, D; Fung-Tomc, J; Huczko, E; Minassian, B; Washo, T1
Capilla, J; Guarro, J; Javier Pastor, F; Ortoneda, M; Pujol, I1
Boyken, L; Diekema, DJ; Hollis, RJ; Jones, RN; Messer, SA; Pfaller, MA1
Armstrong, D; Avila, NA; Bacher, J; Groll, AH; Hemmings, M; Lyman, CA; Mickiene, D; Peter, J; Petraitiene, R; Petraitis, V; Roussillon, K; Walsh, TJ1
Boyken, L; Diekema, DJ; Hollis, RJ; Messer, SA; Pfaller, MA; Rice, C; Tendolkar, S1
Cuenca-Estrella, M; Garcia-Effron, G; Gomez-Lopez, A; Mellado, E; Rodriguez-Tudela, JL1
Gil-Lamaignere, C; Müller, FM; Zhu, LP1
Espinel-Ingroff, A; Jones, RN; Pfaller, MA1
Fernández-Torres, B; Guarro, J; Lazéra, Mdos S; Trilles, L; Wanke, B1
Batra, R; Gupta, AK; Kohli, Y1
Steinbach, WJ1
Conetta, B; Gupta, AK; Leonardi, C; Pierce, PF; Stoltz, RR1
Fothergill, AW; González, GM; Loebenberg, D; Rinaldi, MG; Sutton, DA1
Bacher, J; Groll, AH; Kelaher, A; Mickiene, D; Petraitiene, R; Petraitis, V; Sarafandi, A; Walsh, TJ; Wuerthwein, G1
Baker, CJ; Pannaraj, PS; Walsh, TJ1
Cuenca-Estrella, M; Garcia-Effron, G; Gomez-Lopez, A; Mellado, E; Monzon, A; Rodriguez-Tudela, JL1
Grasela, DM; Kanamaluru, V; Marino, MR; O'Mara, EM; Smith, RA; Yan, JH1
Alves, SH; Azevedo, AC; Boff, E; Da Matta, DA; Guarro, J; Loreto, ES; Santurio, JM1
Aperis, G; Mylonakis, E1
Bacher, J; Kelaher, AM; Lin, P; Meletiadis, J; Petraitiene, R; Petraitis, V; Schaufele, RL; Sein, T; Stergiopoulou, T; Walsh, TJ1
Cano, J; Gené, J; Gilgado, F; Guarro, J; Serena, C1
Denning, DW; Gardiner, RE; Howard, SJ; Moore, CB; Park, S; Perlin, DS; Webster, I1
Alastruey-Izquierdo, A; Alcazar-Fuoli, L; Cuenca-Estrella, M; Mellado, E; Monzon, A; Rodriguez-Tudela, JL1
Knipe, JO; Mosure, KW1
Ayala, J; Elizondo, M; González, GM1
Dannaoui, E; Lortholary, O; Schwarz, P1
Moloney, A1
Goldani, LZ; Pasqualotto, AC; Thiele, KO1
Vera-Cabrera, L; Welsh, E; Welsh, O1
Bahia, MT; Caldas, IS; Carneiro, CM; Crepalde, G; de Lana, M; Diniz, Lde F; Guedes, PM; Talvani, A; Urbina, JA1
Guarro, J; Mayayo, E; Pastor, FJ; Pujol, I; Ruíz-Cendoya, M; Sutton, DA1
Sheng, CQ; Wang, SZ; Zhang, WN1
Türel, O1
Bobade, VD; Gaikwad, ND; Patil, SV1
Aiub, CA; Araújo, JS; Batista, Dda G; Batista, MM; Britto, C; da Silva, CF; da Silva, PB; de Souza, EM; Hargrove, TY; Kim, K; Lepesheva, GI; Lionel, J; Pavão, BP; Soeiro, Mde N; Sulikowski, G; Waterman, MR1
Alexander, PW; Chaplin, JH; Charman, SA; Chatelain, E; Hargrove, TY; Keenan, M; Lepesheva, GI; Perez, CJ; Waterman, MR; Wawrzak, Z1
Jain, MR; Krel, M; Li, H; Perlin, DS; Petraitiene, R; Petraitis, V; Walsh, TJ; Zhao, Y1
Ahmed, SA; de Hoog, GS; Duncanson, F; Fahal, AH; Kloezen, W; van de Sande, WW; Zijlstra, EE1
Ikeda, F; Iyoda, T; Mikawa, T; Suzuki, M; Yamaguchi, H1
Lin, JB; Mast, N; Pikuleva, IA1
Asada, M1
Yamaguchi, H1
Cai, Z; Ding, Z; Jiang, Y; Jin, Y; Li, R; Ni, T; Pang, L; Wang, T; Xie, F; Yu, S; Zhang, D; Zhao, J1
Almeida, IC; Alonso-Vega, C; Alves, F; Gascon, J; Ortiz, L; Pinazo, MJ; Ribeiro, I; Schijman, A; Strub-Wourgaft, N; Torrico, F1
Bahia, MT; Caldas, IS; Diniz, LF; Mazzeti, AL; Ribeiro, I1
Ishii, Y; Ito, Y; Matsuki, S; Ogawa, O; Sanpei, K; Schuck, EL; Takeda, K; Uemura, N1
Cola Fernandes Rodrigues, J; de Souza, W; Lima Prado Godinho, J; Teixeira de Macedo Silva, S; Urbina, JA; Visbal, G1
Okubo, A; Tsubouchi, I; Watanabe, S1
Alonso-Vega, C; Alves, F; de la Barra, A; Flevaud, L; Garcia, L; Gascon, J; Illanes, D; Juiz, N; Ortiz, L; Parrado, R; Ramirez, JC; Ribeiro, I; Schijman, AG; Torrico, F1
Aramaki, C; Kamata, H; Kano, R; Mori, Y; Murayama, N; Yamagishi, K; Yokoi, S1
Fukushima, S; Hiruma, M; Ihn, H; Kano, R; Kimura, U; Matsumoto, T; Noguchi, H; Yaguchi, T2
Huruta, H; Kamata, H; Kano, R1
Ito, T; Kamata, H; Kano, R; Miura, A; Suzuki, K1
Harada, K; Hase, M; Hiruma, J; Hiruma, M; Kamata, H; Kano, R; Noguchi, H; Yokota, M1
Kamata, H; Kano, R; Sugita, T1
Bahia, MT; Caldas, IS; Diniz, LF; Machado, YA; Marques, MJ; Martins-Filho, OA; Mazzeti, AL; Novaes, RD; Santos, LJS; Vilas Boas, BR1
Dong, J; Li, D; Li, X; Liu, W; Mei, H; Song, N; Zheng, H1
Au, HYA; Bhattacharyya, T; Chatelain, E; Franco, CH; Freitas-Junior, LH; Giardini, MA; Le, H; Madeira, RP; Miles, MA; Moraes, CB; Pascoalino, BS; Romera, LMD; Schenkman, S; Torrecilhas, AC; Warhurst, DC1
Hata, K1
Dong, J; Kan, S; Liang, G; Liu, W; Song, N; Zhang, M; Zheng, H1
Brêtas, CM; César, IC; Gazzinelli, BP1
Bahia, MT; de Castro, KCMP; Mazzeti, AL; Mendes, PF; Mosqueira, VCF; Spósito, PÁ; Urbina, JA1
Kumar, G; Kumar, R; Kumar, S; Kumari, M; Saroha, B1
Bonifaz, A; Burrows, J; Eadie, K; Fahal, A; Konings, M; Lim, W; Nyuykonge, B; Perry, B; Samby, K; Smeets, J; Todd, M; van de Sande, W; Verbon, A1
Abastabar, M; Badali, H; Bonifaz, A; Fahal, A; Lim, W; Nyuykonge, B; van Amelsvoort, L; van de Sande, W; Verbon, A1
Bakhiet, S; Fahal, AH; Mhmoud, NA; Nyaoke, BA; Nyuykonge, B; Siddig, EE; van de Sande, WWJ; Verbon, A; Zijlstra, EE1

Reviews

13 review(s) available for triazoles and ravuconazole

ArticleYear
[Present problems and future trend of antifungals for deep seated mycosis. Azole antifungal agents].
    Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology, 1999, Volume: 40, Issue:3

    Topics: Animals; Antifungal Agents; Azoles; Dosage Forms; Drug Interactions; Drug Resistance, Microbial; Fungi; Humans; Pyrimidines; Thiazoles; Triazoles; Voriconazole

1999
Ravuconazole Eisai/Bristol-Myers Squibb.
    Current opinion in investigational drugs (London, England : 2000), 2002, Volume: 3, Issue:4

    Topics: Administration, Oral; Animals; Antifungal Agents; Clinical Trials as Topic; Humans; Mycoses; Structure-Activity Relationship; Thiazoles; Triazoles

2002
[Present status and future prospects of azole antifungal agents in Japan].
    The Japanese journal of antibiotics, 2002, Volume: 55, Issue:6

    Topics: Antifungal Agents; Azoles; Cyclodextrins; Drug Design; Fluconazole; Forecasting; Itraconazole; Japan; Miconazole; Pyrimidines; Thiazoles; Triazoles; Voriconazole

2002
Laboratory evaluation of new antifungal agents against rare and refractory mycoses.
    Current opinion in infectious diseases, 2002, Volume: 15, Issue:6

    Topics: Anti-Bacterial Agents; Antifungal Agents; Caspofungin; Echinocandins; Fungi; Humans; Lipopeptides; Microbial Sensitivity Tests; Mitosporic Fungi; Mycoses; Peptides; Peptides, Cyclic; Pyrimidines; Thiazoles; Triazoles; Voriconazole

2002
New antifungal agents.
    Dermatologic clinics, 2003, Volume: 21, Issue:3

    Topics: Administration, Oral; Anidulafungin; Anti-Bacterial Agents; Antifungal Agents; Caspofungin; Chemistry, Pharmaceutical; Drug Approval; Echinocandins; Humans; Lipopeptides; Macrolides; Mycoses; Peptides; Peptides, Cyclic; Pyrimidines; Thiazoles; Triazoles; Voriconazole

2003
Antifungal agents in children.
    Pediatric clinics of North America, 2005, Volume: 52, Issue:3

    Topics: Age Factors; Amphotericin B; Anidulafungin; Antifungal Agents; Caspofungin; Chemistry, Pharmaceutical; Child; Clinical Trials as Topic; Drug Approval; Drug Resistance, Fungal; Echinocandins; Fluconazole; Flucytosine; Humans; Itraconazole; Lipopeptides; Lipoproteins; Micafungin; Mycoses; Patient Selection; Pediatrics; Peptides, Cyclic; Pyrimidines; Safety; Thiazoles; Triazoles; United States; Voriconazole

2005
Newer triazole antifungal agents: pharmacology, spectrum, clinical efficacy and limitations.
    Expert opinion on investigational drugs, 2006, Volume: 15, Issue:6

    Topics: Animals; Antifungal Agents; Aspergillosis; Candidiasis; Cryptococcosis; Drug Administration Schedule; Drug Evaluation, Preclinical; Drug Resistance, Fungal; Drug Therapy, Combination; Humans; Pyrimidines; Randomized Controlled Trials as Topic; Thiazoles; Triazoles; Voriconazole

2006
Novel triazole antifungal drugs: focus on isavuconazole, ravuconazole and albaconazole.
    Current opinion in investigational drugs (London, England : 2000), 2010, Volume: 11, Issue:2

    Topics: Animals; Antifungal Agents; Clinical Trials as Topic; Drug Resistance, Fungal; Fungi; Humans; Microbial Sensitivity Tests; Mycoses; Nitriles; Pyridines; Quinazolines; Thiazoles; Triazoles

2010
Onychomycosis.
    Clinics in dermatology, 2010, Mar-04, Volume: 28, Issue:2

    Topics: Administration, Cutaneous; Administration, Oral; Antifungal Agents; Ciclopirox; Drug Administration Schedule; Drug Therapy, Combination; Fluconazole; Foot Dermatoses; Humans; Itraconazole; Mitosporic Fungi; Morpholines; Naphthalenes; Onychomycosis; Pyridones; Pyrimidines; Terbinafine; Thiazoles; Triazoles; Voriconazole

2010
[Recent advances in the study of new antifungal lead compounds].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2010, Volume: 45, Issue:8

    Topics: Antifungal Agents; Fungi; Heterocyclic Compounds; Humans; Lipopeptides; Molecular Structure; Mycoses; Nitriles; Plant Extracts; Plants, Medicinal; Pyridines; Quinazolines; Quinones; Structure-Activity Relationship; Thiazoles; Triazoles

2010
Newer antifungal agents.
    Expert review of anti-infective therapy, 2011, Volume: 9, Issue:3

    Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus; Candida; Candidiasis, Invasive; Child; Clinical Trials as Topic; Half-Life; Humans; Lipopeptides; Nitriles; Pyridines; Quinazolines; Thiazoles; Triazoles

2011
Potential of Ravuconazole and its Prodrugs as the New OralTherapeutics for Onychomycosis.
    Medical mycology journal, 2016, Volume: 57, Issue:4

    Topics: Administration, Oral; Antifungal Agents; Arthrodermataceae; Candida; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Drug Discovery; Humans; Onychomycosis; Prodrugs; Thiazoles; Triazoles

2016
A minireview of 1,2,3-triazole hybrids with O-heterocycles as leads in medicinal chemistry.
    Chemical biology & drug design, 2022, Volume: 100, Issue:6

    Topics: Azides; Chemistry, Pharmaceutical; Cycloaddition Reaction; Drug Design; Molecular Structure; Structure-Activity Relationship; Triazoles

2022

Trials

6 trial(s) available for triazoles and ravuconazole

ArticleYear
A phase I/II randomized, double-blind, placebo-controlled, dose-ranging study evaluating the efficacy, safety and pharmacokinetics of ravuconazole in the treatment of onychomycosis.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2005, Volume: 19, Issue:4

    Topics: Administration, Oral; Antifungal Agents; Double-Blind Method; Drug Administration Schedule; Foot Dermatoses; France; Humans; Nails; Ontario; Onychomycosis; Severity of Illness Index; Thiazoles; Treatment Outcome; Triazoles; United States

2005
The effect of ravuconazole on the pharmacokinetics of nelfinavir in healthy male volunteers.
    Journal of clinical pharmacology, 2006, Volume: 46, Issue:2

    Topics: Adolescent; Adult; Anti-HIV Agents; Area Under Curve; Cytochrome P-450 CYP3A; Drug Interactions; Half-Life; Humans; Male; Middle Aged; Nelfinavir; Thiazoles; Triazoles

2006
Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled trial.
    The Lancet. Infectious diseases, 2018, Volume: 18, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Bolivia; Chagas Disease; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Incidence; Male; Middle Aged; Nitroimidazoles; Parasite Load; Placebos; Polymerase Chain Reaction; Prospective Studies; Thiazoles; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Young Adult

2018
Clinical Drug-Drug Interaction Potential of BFE1224, Prodrug of Antifungal Ravuconazole, Using Two Types of Cocktails in Healthy Subjects.
    Clinical and translational science, 2018, Volume: 11, Issue:5

    Topics: Administration, Oral; Adult; Antifungal Agents; Biological Assay; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Healthy Volunteers; Humans; Male; Metabolome; Onychomycosis; Prodrugs; Thiazoles; Triazoles; Young Adult

2018
Efficacy and safety of fosravuconazole L-lysine ethanolate, a novel oral triazole antifungal agent, for the treatment of onychomycosis: A multicenter, double-blind, randomized phase III study.
    The Journal of dermatology, 2018, Volume: 45, Issue:10

    Topics: Adult; Aged; Antifungal Agents; Double-Blind Method; Female; Foot Dermatoses; Humans; Male; Middle Aged; Onychomycosis; Prodrugs; Thiazoles; Treatment Outcome; Triazoles; Young Adult

2018
Usefulness of Serial Blood Sampling and PCR Replicates for Treatment Monitoring of Patients with Chronic Chagas Disease.
    Antimicrobial agents and chemotherapy, 2019, Volume: 63, Issue:2

    Topics: Adolescent; Adult; Chagas Disease; DNA, Protozoan; Humans; Middle Aged; Monitoring, Physiologic; Nitroimidazoles; Parasite Load; Placebos; Real-Time Polymerase Chain Reaction; Thiazoles; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Young Adult

2019

Other Studies

82 other study(ies) available for triazoles and ravuconazole

ArticleYear
In vitro and in vivo antifungal activities of ER-30346, a novel oral triazole with a broad antifungal spectrum.
    Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:10

    Topics: Animals; Antifungal Agents; Aspergillosis; Candidiasis; Cryptococcosis; Female; Fluconazole; Fungi; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Thiazoles; Triazoles

1996
Efficacy of ER-30346, a novel oral triazole antifungal agent, in experimental models of aspergillosis, candidiasis, and cryptococcosis.
    Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:10

    Topics: Animals; Antifungal Agents; Aspergillosis; Brain Diseases; Candidiasis; Candidiasis, Oral; Cryptococcosis; Female; Fluconazole; Lung Diseases, Fungal; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Rats; Rats, Sprague-Dawley; Thiazoles; Triazoles

1996
In vitro activity of a new oral triazole, BMS-207147 (ER-30346)
    Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:2

    Topics: Amphotericin B; Antifungal Agents; Candida; Cryptococcus; Microbial Sensitivity Tests; Thiazoles; Triazoles

1998
Synthesis and antifungal activity of novel thiazole-containing triazole antifungals. II. Optically active ER-30346 and its derivatives.
    Chemical & pharmaceutical bulletin, 1998, Volume: 46, Issue:4

    Topics: Animals; Antifungal Agents; Candidiasis; Culture Media; Fungi; Mice; Microbial Sensitivity Tests; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Triazoles

1998
In vitro susceptibilities of Candida bloodstream isolates to the new triazole antifungal agents BMS-207147, Sch 56592, and voriconazole.
    Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:12

    Topics: Antifungal Agents; Candida; Candidiasis; Humans; Microbial Sensitivity Tests; Pyrimidines; Thiazoles; Triazoles; Voriconazole

1998
In vitro susceptibilities of Candida dubliniensis isolates tested against the new triazole and echinocandin antifungal agents.
    Journal of clinical microbiology, 1999, Volume: 37, Issue:3

    Topics: AIDS-Related Opportunistic Infections; Amphotericin B; Anti-Bacterial Agents; Antifungal Agents; Candida; Candidiasis; Caspofungin; Echinocandins; Fluconazole; Flucytosine; Humans; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Peptides; Peptides, Cyclic; Pyrimidines; Thiazoles; Triazoles; Voriconazole

1999
In vitro activities of BMS-207147 against over 600 contemporary clinical bloodstream isolates of Candida species from the SENTRY Antimicrobial Surveillance Program in North America and Latin America.
    Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:9

    Topics: Antifungal Agents; Candida; Dose-Response Relationship, Drug; Fluconazole; Humans; Itraconazole; Latin America; Microbial Sensitivity Tests; North America; Population Surveillance; Thiazoles; Triazoles

1999
ER 30346. BMS 207147.
    Drugs in R&D, 1999, Volume: 1, Issue:2

    Topics: Animals; Antifungal Agents; Dogs; Drug Interactions; Drugs, Investigational; Fungi; Humans; Mycoses; Rats; Thiazoles; Triazoles

1999
In vitro antifungal activity of BMS-207147 and itraconazole against yeast strains that are non-susceptible to fluconazole.
    Diagnostic microbiology and infectious disease, 1999, Volume: 35, Issue:2

    Topics: Antifungal Agents; Candida; Drug Resistance, Microbial; Fluconazole; Itraconazole; Microbial Sensitivity Tests; Thiazoles; Triazoles

1999
In vitro activity of the new triazole BMS-207147 against Aspergillus species in comparison with itraconazole and amphotericin B.
    Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:2

    Topics: Amphotericin B; Antifungal Agents; Aspergillus; Drug Resistance, Microbial; Humans; Itraconazole; Microbial Sensitivity Tests; Thiazoles; Triazoles

2000
In vitro activities of ravuconazole (BMS-207147) against 541 clinical isolates of Cryptococcus neoformans.
    Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:10

    Topics: Antifungal Agents; Cryptococcosis; Cryptococcus neoformans; Fluconazole; Humans; Itraconazole; Microbial Sensitivity Tests; Thiazoles; Triazoles

2000
Efficacies of two new antifungal agents, the triazole ravuconazole and the echinocandin LY-303366, in an experimental model of invasive aspergillosis.
    Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:12

    Topics: Anidulafungin; Animals; Antibiotic Prophylaxis; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Brain; Disease Models, Animal; Echinocandins; Liver; Lung; Peptides, Cyclic; Rabbits; Thiazoles; Triazoles

2000
In vitro activities of four novel triazoles against Scedosporium spp.
    Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:7

    Topics: Antifungal Agents; Humans; Microbial Sensitivity Tests; Pyrimidines; Quinazolines; Scedosporium; Thiazoles; Triazoles; Voriconazole

2001
International surveillance of bloodstream infections due to Candida species: frequency of occurrence and in vitro susceptibilities to fluconazole, ravuconazole, and voriconazole of isolates collected from 1997 through 1999 in the SENTRY antimicrobial surv
    Journal of clinical microbiology, 2001, Volume: 39, Issue:9

    Topics: Antifungal Agents; Candida; Candidiasis; Europe; Fluconazole; Fungemia; Humans; Latin America; North America; Pyrimidines; Sentinel Surveillance; Thiazoles; Triazoles; Voriconazole

2001
Efficacy of ravuconazole in treatment of mucosal candidosis in SCID mice.
    Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:12

    Topics: Administration, Oral; Animals; Antifungal Agents; Candidiasis, Chronic Mucocutaneous; Digestive System; Dose-Response Relationship, Drug; Female; Mice; Mice, SCID; Microbial Sensitivity Tests; Thiazoles; Triazoles

2001
Efficacy of ravuconazole (BMS-207147) in a guinea pig model of disseminated aspergillosis.
    The Journal of antimicrobial chemotherapy, 2002, Volume: 49, Issue:2

    Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Disease Models, Animal; Drug Evaluation, Preclinical; Guinea Pigs; Humans; Male; Organ Culture Techniques; Organ Specificity; Thiazoles; Triazoles

2002
Efficacy of ravuconazole in treatment of systemic murine histoplasmosis.
    Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:3

    Topics: Animals; Antifungal Agents; Colony Count, Microbial; Female; Fluconazole; Histoplasmosis; Itraconazole; Liver; Mice; Spleen; Survival; Survival Analysis; Thiazoles; Triazoles

2002
Antifungal activities of posaconazole, ravuconazole, and voriconazole compared to those of itraconazole and amphotericin B against 239 clinical isolates of Aspergillus spp. and other filamentous fungi: report from SENTRY Antimicrobial Surveillance Program
    Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:4

    Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus; Canada; Fungi; Humans; Microbial Sensitivity Tests; Mycoses; Pyrimidines; Quality Control; Thiazoles; Triazoles; United States; Voriconazole

2002
Penetration of ravuconazole, a new triazole antifungal, into rat tissues.
    Chemotherapy, 2002, Volume: 48, Issue:1

    Topics: Administration, Oral; Animals; Antifungal Agents; Biological Availability; Female; Half-Life; Lung; Rats; Specific Pathogen-Free Organisms; Thiazoles; Triazoles; Uterus

2002
Clinical evaluation of a frozen commercially prepared microdilution panel for antifungal susceptibility testing of seven antifungal agents, including the new triazoles posaconazole, ravuconazole, and voriconazole.
    Journal of clinical microbiology, 2002, Volume: 40, Issue:5

    Topics: Antifungal Agents; Candida; Freezing; Humans; Microbial Sensitivity Tests; Pyrimidines; Thiazoles; Triazoles; Voriconazole

2002
In vitro activities of ravuconazole and voriconazole compared with those of four approved systemic antifungal agents against 6,970 clinical isolates of Candida spp.
    Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:6

    Topics: Antifungal Agents; Candida; Candidiasis; Drug Resistance, Microbial; Humans; Microbial Sensitivity Tests; Pyrimidines; Thiazoles; Triazoles; Voriconazole

2002
In vitro activity of three new triazoles and one echinocandin against Candida bloodstream isolates from cancer patients.
    The Journal of antimicrobial chemotherapy, 2002, Volume: 50, Issue:1

    Topics: Antifungal Agents; Blood; Candida; Candidiasis; Echinocandins; Humans; In Vitro Techniques; Lipopeptides; Lipoproteins; Micafungin; Microbial Sensitivity Tests; Neoplasms; Peptides, Cyclic; Pyrimidines; Thiazoles; Triazoles; Voriconazole

2002
Synthesis of novel water soluble benzylazolium prodrugs of lipophilic azole antifungals.
    Bioorganic & medicinal chemistry letters, 2002, Oct-07, Volume: 12, Issue:19

    Topics: Animals; Antifungal Agents; Aspergillus fumigatus; Azoles; Candida albicans; Candidiasis; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Itraconazole; Ketoconazole; Microbial Sensitivity Tests; Prodrugs; Rats; Solubility; Thiazoles; Triazoles

2002
In vitro and in vivo activities of ravuconazole on Trypanosoma cruzi, the causative agent of Chagas disease.
    International journal of antimicrobial agents, 2003, Volume: 21, Issue:1

    Topics: Animals; Chagas Disease; Dose-Response Relationship, Drug; Drug Resistance; Female; Mice; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2003
In vivo pharmacodynamics of a new triazole, ravuconazole, in a murine candidiasis model.
    Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:4

    Topics: Animals; Antifungal Agents; Area Under Curve; Candidiasis; Disease Models, Animal; Female; Humans; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Thiazoles; Triazoles

2003
Combination therapy in treatment of experimental pulmonary aspergillosis: synergistic interaction between an antifungal triazole and an echinocandin.
    The Journal of infectious diseases, 2003, Jun-15, Volume: 187, Issue:12

    Topics: Animals; Aspergillosis; Aspergillus fumigatus; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Echinocandins; Female; Lipopeptides; Lipoproteins; Lung; Lung Diseases, Fungal; Micafungin; Organ Size; Peptides, Cyclic; Rabbits; Thiazoles; Triazoles

2003
Activities of caspofungin, itraconazole, posaconazole, ravuconazole, voriconazole, and amphotericin B against 448 recent clinical isolates of filamentous fungi.
    Journal of clinical microbiology, 2003, Volume: 41, Issue:8

    Topics: Amphotericin B; Anti-Bacterial Agents; Aspergillus; Caspofungin; Echinocandins; Fungi; Humans; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Mycoses; Penicillium; Peptides; Peptides, Cyclic; Pyrimidines; Thiazoles; Triazoles; Voriconazole

2003
In vitro activities of new antifungal agents against Chaetomium spp. and inoculum standardization.
    Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:10

    Topics: Antifungal Agents; Chaetomium; Colony Count, Microbial; Humans; Microbial Sensitivity Tests; Mitosporic Fungi; Pyrimidines; Reference Standards; Thiazoles; Triazoles; Voriconazole

2003
Phosphonooxymethyl prodrugs of the broad spectrum antifungal azole, ravuconazole: synthesis and biological properties.
    Bioorganic & medicinal chemistry letters, 2003, Nov-03, Volume: 13, Issue:21

    Topics: Animals; Antifungal Agents; Candidiasis; Drug Stability; Female; Humans; Indicators and Reagents; Infusions, Intravenous; Mice; Mice, Inbred ICR; Prodrugs; Rats; Solubility; Structure-Activity Relationship; Survival; Thiazoles; Triazoles

2003
In vitro activity of ravuconazole against Zygomycetes, Scedosporium and Fusarium isolates.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2003, Volume: 9, Issue:12

    Topics: Amphotericin B; Antifungal Agents; Fungi; Fusarium; Itraconazole; Microbial Sensitivity Tests; Pyrimidines; Scedosporium; Thiazoles; Triazoles; Voriconazole

2003
In vitro interactions of licensed and novel antifungal drugs against Fusarium spp.
    Diagnostic microbiology and infectious disease, 2004, Volume: 48, Issue:1

    Topics: Amphotericin B; Antifungal Agents; Drug Interactions; Drug Resistance, Fungal; Fusarium; Humans; Itraconazole; Microbial Sensitivity Tests; Naphthalenes; Pyrimidines; Quinazolines; Sensitivity and Specificity; Terbinafine; Thiazoles; Triazoles; Voriconazole

2004
In vitro susceptibilities of rare Candida bloodstream isolates to ravuconazole and three comparative antifungal agents.
    Diagnostic microbiology and infectious disease, 2004, Volume: 48, Issue:2

    Topics: Amphotericin B; Antifungal Agents; Candida; Candidiasis; Drug Resistance, Fungal; Fluconazole; Flucytosine; Fungemia; Humans; Microbial Sensitivity Tests; Thiazoles; Triazoles

2004
Efficacy, safety, and plasma pharmacokinetics of escalating dosages of intravenously administered ravuconazole lysine phosphoester for treatment of experimental pulmonary aspergillosis in persistently neutropenic rabbits.
    Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:4

    Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis, Allergic Bronchopulmonary; Aspergillus fumigatus; Dose-Response Relationship, Drug; Female; Galactose; Half-Life; Image Processing, Computer-Assisted; Immunosuppressive Agents; Injections, Intravenous; Lung; Mannans; Microbial Sensitivity Tests; Neutropenia; Rabbits; Survival Analysis; Tetrazolium Salts; Thiazoles; Tomography, X-Ray Computed; Triazoles

2004
Cross-resistance between fluconazole and ravuconazole and the use of fluconazole as a surrogate marker to predict susceptibility and resistance to ravuconazole among 12,796 clinical isolates of Candida spp.
    Journal of clinical microbiology, 2004, Volume: 42, Issue:7

    Topics: Antifungal Agents; Candida; Drug Resistance, Fungal; Fluconazole; Humans; Microbial Sensitivity Tests; Thiazoles; Triazoles

2004
In vitro activities of ravuconazole and four other antifungal agents against fluconazole-resistant or -susceptible clinical yeast isolates.
    Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:8

    Topics: Antifungal Agents; Candidiasis; Drug Resistance, Fungal; Fluconazole; Humans; Microbial Sensitivity Tests; Thiazoles; Triazoles; Yeasts

2004
Effects of several antifungal drug combinations against clinical and environmental isolates of Cryptococcus neoformans from China.
    Mycoses, 2004, Volume: 47, Issue:7

    Topics: Animals; Antifungal Agents; Caspofungin; China; Columbidae; Cryptococcosis; Cryptococcus neoformans; Drug Interactions; Echinocandins; Feces; Flucytosine; Humans; Lipopeptides; Microbial Sensitivity Tests; Naphthalenes; Peptides; Peptides, Cyclic; Terbinafine; Thiazoles; Triazoles

2004
Clinical evaluation of the Sensititre YeastOne colorimetric antifungal plate for antifungal susceptibility testing of the new triazoles voriconazole, posaconazole, and ravuconazole.
    Journal of clinical microbiology, 2004, Volume: 42, Issue:10

    Topics: Antifungal Agents; Candida; Candidiasis; Humans; Microbial Sensitivity Tests; Pyrimidines; Reagent Kits, Diagnostic; Thiazoles; Triazoles; Voriconazole

2004
In vitro antifungal susceptibility of Cryptococcus gattii.
    Journal of clinical microbiology, 2004, Volume: 42, Issue:10

    Topics: Antifungal Agents; Cryptococcus; Cryptococcus neoformans; Humans; Microbial Sensitivity Tests; Quinazolines; Thiazoles; Triazoles

2004
In vitro activities of posaconazole, ravuconazole, terbinafine, itraconazole and fluconazole against dermatophyte, yeast and non-dermatophyte species.
    Medical mycology, 2005, Volume: 43, Issue:2

    Topics: Antifungal Agents; Arthrodermataceae; Fluconazole; Fungi; Humans; Itraconazole; Microbial Sensitivity Tests; Mycoses; Naphthalenes; Terbinafine; Thiazoles; Triazoles; Yeasts

2005
In vitro activities of new and established triazoles against opportunistic filamentous and dimorphic fungi.
    Medical mycology, 2005, Volume: 43, Issue:3

    Topics: Antifungal Agents; Fungi; Humans; Microbial Sensitivity Tests; Mycoses; Pyrimidines; Species Specificity; Thiazoles; Triazoles; Voriconazole

2005
Compartmental pharmacokinetics and tissue distribution of the antifungal triazole ravuconazole following intravenous administration of its di-lysine phosphoester prodrug (BMS-379224) in rabbits.
    The Journal of antimicrobial chemotherapy, 2005, Volume: 56, Issue:5

    Topics: Adipose Tissue; Animals; Brain; Half-Life; Injections, Intravenous; Kidney; Liver; Lung; Lysine; Prodrugs; Rabbits; Thiazoles; Tissue Distribution; Triazoles

2005
Advances in antifungal therapy.
    The Pediatric infectious disease journal, 2005, Volume: 24, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anidulafungin; Animals; Antifungal Agents; Caspofungin; Child; Child, Preschool; Clinical Trials as Topic; Echinocandins; Fungal Proteins; Humans; Infant; Infant, Newborn; Lipopeptides; Lipoproteins; Micafungin; Middle Aged; Mycoses; Peptides, Cyclic; Pyrimidines; Thiazoles; Treatment Outcome; Triazoles; Voriconazole

2005
In vitro activity of ravuconazole against 923 clinical isolates of nondermatophyte filamentous fungi.
    Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:12

    Topics: Antifungal Agents; Fungi; Humans; Microbial Sensitivity Tests; Thiazoles; Triazoles

2005
In vitro activities of new and conventional antimycotics against fluconazole-susceptible and non-susceptible Brazilian Candida spp. isolates.
    Mycoses, 2006, Volume: 49, Issue:3

    Topics: Antifungal Agents; Brazil; Candida; Candidiasis; Drug Resistance, Fungal; Fluconazole; Humans; Microbial Sensitivity Tests; Quinazolines; Thiazoles; Triazoles

2006
Triazole-polyene antagonism in experimental invasive pulmonary aspergillosis: in vitro and in vivo correlation.
    The Journal of infectious diseases, 2006, Oct-01, Volume: 194, Issue:7

    Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Drug Antagonism; Drug Therapy, Combination; Humans; Liposomes; Lung Diseases, Fungal; Microbial Sensitivity Tests; Models, Biological; Polyenes; Rabbits; Thiazoles; Triazoles

2006
Antifungal susceptibilities of the species of the Pseudallescheria boydii complex.
    Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:12

    Topics: Amphotericin B; Antifungal Agents; Candida; Drug Resistance, Fungal; Echinocandins; Fluconazole; Flucytosine; Humans; Itraconazole; Ketoconazole; Lipopeptides; Lipoproteins; Micafungin; Microbial Sensitivity Tests; Naphthalenes; Peptides, Cyclic; Pseudallescheria; Pyrimidines; Quality Control; Quinazolines; Scedosporium; Terbinafine; Thiazoles; Triazoles; Voriconazole

2006
Multi-azole resistance in Aspergillus fumigatus.
    International journal of antimicrobial agents, 2006, Volume: 28, Issue:5

    Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Caspofungin; Cytochrome P-450 Enzyme System; Drug Resistance, Multiple, Fungal; Echinocandins; Fungal Proteins; Humans; Itraconazole; Lipopeptides; Lung Diseases, Fungal; Male; Microbial Sensitivity Tests; Middle Aged; Mutation, Missense; Peptides, Cyclic; Pyrimidines; Thiazoles; Triazoles; Voriconazole

2006
Epidemiological cutoffs and cross-resistance to azole drugs in Aspergillus fumigatus.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:7

    Topics: Amino Acid Substitution; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Azoles; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Fungal Proteins; Genes, Fungal; Humans; Itraconazole; Microbial Sensitivity Tests; Molecular Epidemiology; Molecular Sequence Data; Pyrimidines; Thiazoles; Triazoles; Voriconazole

2008
Nonclinical pharmacokinetics of BMS-292655, a water-soluble prodrug of the antifungal ravuconazole.
    Biopharmaceutics & drug disposition, 2008, Volume: 29, Issue:5

    Topics: Animals; Antifungal Agents; Blood Proteins; Dogs; Humans; Hydrolysis; In Vitro Techniques; Macaca fascicularis; Male; Prodrugs; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Thiazoles; Triazoles

2008
Trends in species distribution and susceptibility of bloodstream isolates of Candida collected in Monterrey, Mexico, to seven antifungal agents: results of a 3-year (2004 to 2007) surveillance study.
    Journal of clinical microbiology, 2008, Volume: 46, Issue:9

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Amphotericin B; Antifungal Agents; Candida; Candida albicans; Candida glabrata; Candida tropicalis; Candidiasis; Caspofungin; Child; Child, Preschool; Echinocandins; Female; Fluconazole; Humans; Infant; Infant, Newborn; Itraconazole; Lipopeptides; Male; Mexico; Microbial Sensitivity Tests; Middle Aged; Pyrimidines; Thiazoles; Triazoles; Voriconazole; Young Adult

2008
In vitro interactions between antifungals and immunosuppressive drugs against zygomycetes.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:8

    Topics: Amphotericin B; Antifungal Agents; Azoles; Cyclosporine; Drug Interactions; Immunosuppressive Agents; Itraconazole; Microbial Sensitivity Tests; Mucorales; Rhizopus; Sirolimus; Tacrolimus; Thiazoles; Triazoles

2009
Trial renews interest in Chagas' disease.
    Lancet (London, England), 2009, Oct-31, Volume: 374, Issue:9700

    Topics: Chagas Disease; Clinical Trials, Phase I as Topic; Drug Industry; Global Health; Humans; Latin America; Prodrugs; Research Support as Topic; Thiazoles; Triazoles

2009
Effects of ravuconazole treatment on parasite load and immune response in dogs experimentally infected with Trypanosoma cruzi.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:7

    Topics: Animals; Chagas Disease; Dogs; Enzyme-Linked Immunosorbent Assay; Immunoglobulin G; Interferon-gamma; Interleukin-10; Myocardium; Polymerase Chain Reaction; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2010
In vitro and in vivo antifungal susceptibilities of the Mucoralean fungus Cunninghamella.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:11

    Topics: Amphotericin B; Animals; Antifungal Agents; Caspofungin; Cunninghamella; Diabetes Mellitus, Experimental; Echinocandins; Itraconazole; Lipopeptides; Male; Mice; Microbial Sensitivity Tests; Mucormycosis; Pyrimidines; Thiazoles; Triazoles; Voriconazole

2010
Hybrids of ravuconazole: synthesis and biological evaluation.
    European journal of medicinal chemistry, 2012, Volume: 54

    Topics: Anti-Infective Agents; Aspergillus niger; Bacteria; Candida albicans; Chemistry Techniques, Synthetic; Microbial Sensitivity Tests; Thiazoles; Triazoles

2012
In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:9

    Topics: 14-alpha Demethylase Inhibitors; Animals; Chagas Disease; Drug Resistance; Endoplasmic Reticulum; Golgi Apparatus; Imidazoles; Male; Mice; Microscopy, Electron, Transmission; Nitroimidazoles; Oxadiazoles; Protozoan Proteins; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2013
Complexes of Trypanosoma cruzi sterol 14α-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: structural basis for pathogen selectivity.
    The Journal of biological chemistry, 2013, Nov-01, Volume: 288, Issue:44

    Topics: 14-alpha Demethylase Inhibitors; Antiprotozoal Agents; Chagas Disease; Crystallography, X-Ray; Humans; Protozoan Proteins; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanosoma cruzi

2013
Host biomarkers of invasive pulmonary aspergillosis to monitor therapeutic response.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:6

    Topics: Amphotericin B; Animals; Annexin A1; Antifungal Agents; Aspergillus fumigatus; Biomarkers; Bronchoalveolar Lavage Fluid; C-Reactive Protein; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Invasive Pulmonary Aspergillosis; Neutropenia; Proteomics; Rabbits; Thiazoles; Triazoles

2014
Madurella mycetomatis is highly susceptible to ravuconazole.
    PLoS neglected tropical diseases, 2014, Volume: 8, Issue:6

    Topics: Antifungal Agents; Itraconazole; Ketoconazole; Madurella; Microbial Sensitivity Tests; Thiazoles; Triazoles

2014
[In vitro antifungal activity of ravuconazole against isolates of dermatophytes and Candida species from patients with dermatomycoses].
    Medical mycology journal, 2014, Volume: 55, Issue:4

    Topics: Antifungal Agents; Arthrodermataceae; Candida; Dermatomycoses; Dose-Response Relationship, Drug; Drug Resistance, Fungal; Humans; Itraconazole; Naphthalenes; Terbinafine; Thiazoles; Triazoles

2014
Marketed Drugs Can Inhibit Cytochrome P450 27A1, a Potential New Target for Breast Cancer Adjuvant Therapy.
    Molecular pharmacology, 2015, Volume: 88, Issue:3

    Topics: Adjuvants, Pharmaceutic; Anastrozole; Anilides; Animals; Antifungal Agents; Antineoplastic Agents; Breast Neoplasms; Cholestanetriol 26-Monooxygenase; Dexmedetomidine; Enzyme Inhibitors; Fadrozole; Female; Hypnotics and Sedatives; Mice; Mice, Inbred C57BL; Nitriles; Protein Binding; Thiazoles; Tosyl Compounds; Triazoles

2015
[Development and Distribution of Drugs for NTDs: Efforts of One Pharmaceutical Company].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2016, Volume: 136, Issue:2

    Topics: Animals; Antifungal Agents; Chagas Disease; Cost-Benefit Analysis; Drug Discovery; Drug Industry; Global Health; Humans; Intersectoral Collaboration; Mice; Neglected Diseases; Prodrugs; Thiazoles; Triazoles; Tropical Medicine

2016
Design, synthesis, and in vitro evaluation of novel antifungal triazoles.
    Bioorganic & medicinal chemistry letters, 2017, 05-15, Volume: 27, Issue:10

    Topics: Antifungal Agents; Crystallography, X-Ray; Drug Design; Fungi; Microbial Sensitivity Tests; Molecular Conformation; Nitriles; Pyridines; Structure-Activity Relationship; Thiazoles; Triazoles

2017
Outcome of E1224-Benznidazole Combination Treatment for Infection with a Multidrug-Resistant Trypanosoma cruzi Strain in Mice.
    Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:6

    Topics: Animals; Combined Modality Therapy; Disease Models, Animal; Drug Interactions; Female; Mice; Microbial Sensitivity Tests; Nitroimidazoles; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2018
In vitro antileishmanial activity of ravuconazole, a triazole antifungal drug, as a potential treatment for leishmaniasis.
    The Journal of antimicrobial chemotherapy, 2018, 09-01, Volume: 73, Issue:9

    Topics: Antiprotozoal Agents; Drug Repositioning; Flow Cytometry; Fluorometry; Inhibitory Concentration 50; Leishmania mexicana; Mass Spectrometry; Microscopy, Electron; Microscopy, Fluorescence; Parasitic Sensitivity Tests; Thiazoles; Triazoles

2018
High multi-azole-resistant Malassezia pachydermatis clinical isolates from canine Malassezia dermatitis.
    Medical mycology, 2020, Feb-01, Volume: 58, Issue:2

    Topics: Animals; Antifungal Agents; Azoles; Dermatomycoses; Dog Diseases; Dogs; Drug Resistance, Multiple, Fungal; Itraconazole; Japan; Malassezia; Microbial Sensitivity Tests; Thiazoles; Triazoles

2020
Fungal melanonychia caused by Candida parapsilosis successfully treated with oral fosravuconazole.
    The Journal of dermatology, 2019, Volume: 46, Issue:10

    Topics: Administration, Oral; Aged; Antifungal Agents; Candida parapsilosis; Female; Hand Dermatoses; Humans; Melanosis; Onychomycosis; Prodrugs; Thiazoles; Treatment Outcome; Triazoles

2019
Tinea unguium caused by terbinafine-resistant Trichophyton rubrum successfully treated with fosravuconazole.
    The Journal of dermatology, 2019, Volume: 46, Issue:12

    Topics: Aged; Antifungal Agents; Drug Resistance, Fungal; Female; Hand Dermatoses; Humans; Onychomycosis; Terbinafine; Thiazoles; Tinea; Triazoles

2019
Antifungal susceptibility of dermatophyte isolates from companion animals to ravuconazole.
    Veterinary dermatology, 2020, Volume: 31, Issue:2

    Topics: Animals; Antifungal Agents; Cats; Drug Resistance, Multiple, Fungal; Microbial Sensitivity Tests; Microsporum; Thiazoles; Tinea; Triazoles

2020
In vitro algaecid effect of itraconazole and ravuconazole on Prototheca species.
    Medical mycology, 2020, Aug-01, Volume: 58, Issue:6

    Topics: Humans; Infections; Itraconazole; Microbial Sensitivity Tests; Prototheca; Thiazoles; Triazoles

2020
In Vitro Ravuconazole Susceptibility of Anthropophilic Dermatophyte Strains Isolated from Japanese Patients.
    Japanese journal of infectious diseases, 2020, May-22, Volume: 73, Issue:3

    Topics: Antifungal Agents; Arthrodermataceae; Dermatomycoses; Drug Resistance, Fungal; Humans; Itraconazole; Microbial Sensitivity Tests; Terbinafine; Thiazoles; Triazoles

2020
Antifungal Susceptibility of Clinical Isolates and Artificially Produced Multi-azole-resistant Strains of Cryptococcus neoformans (formerly: Cryptococcus grubii) to Ravuconazole.
    Medical mycology journal, 2020, Volume: 61, Issue:1

    Topics: Antifungal Agents; Cryptococcus neoformans; Drug Resistance, Fungal; Thiazoles; Triazoles

2020
Amlodipine Increases the Therapeutic Potential of Ravuconazole upon Trypanosoma cruzi Infection.
    Antimicrobial agents and chemotherapy, 2020, 07-22, Volume: 64, Issue:8

    Topics: Amlodipine; Animals; Chagas Disease; Mice; Nitroimidazoles; Parasitemia; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2020
    Antimicrobial agents and chemotherapy, 2020, 08-20, Volume: 64, Issue:9

    Topics: Antifungal Agents; Ascomycota; Fungi; Microbial Sensitivity Tests; Nitriles; Pyridines; Thiazoles; Triazoles; Voriconazole

2020
Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity.
    International journal for parasitology. Drugs and drug resistance, 2020, Volume: 13

    Topics: 14-alpha Demethylase Inhibitors; Animals; Cell Line; Chagas Disease; Drug Resistance, Multiple; Genes, Protozoan; Mutation; Nitroimidazoles; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2020
Development of E1224 by leveraging a strategic partnership for the medicines creation against neglected tropical diseases.
    Parasitology international, 2021, Volume: 81

    Topics: Chagas Disease; Global Health; Neglected Diseases; Thiazoles; Triazoles; Tropical Medicine; Trypanocidal Agents; Trypanosoma cruzi

2021
In Vitro activity of ravuconazole against Candida auris and vaginal candida isolates.
    Mycoses, 2021, Volume: 64, Issue:6

    Topics: Amphotericin B; Antifungal Agents; Candida; Candidiasis; Drug Resistance, Fungal; Female; Humans; In Vitro Techniques; Microbial Sensitivity Tests; Thiazoles; Triazoles; Vagina

2021
Development of a stability-indicating assay method by HPLC-DAD and MS characterization of forced degradation products of ravuconazole.
    Journal of chromatographic science, 2022, Feb-16, Volume: 60, Issue:2

    Topics: Chromatography, High Pressure Liquid; Drug Stability; Hydrogen Peroxide; Hydrolysis; Reproducibility of Results; Thiazoles; Triazoles

2022
Higher oral efficacy of ravuconazole in self-nanoemulsifying systems in shorter treatment in experimental chagas disease.
    Experimental parasitology, 2021, Volume: 228

    Topics: Animals; Chagas Disease; Emulsions; Female; Hep G2 Cells; Humans; Inhibitory Concentration 50; Mice; Myocytes, Cardiac; Nanostructures; Rats; Thiazoles; Triazoles; Trypanosoma cruzi

2021
Screening the pandemic response box identified benzimidazole carbamates, Olorofim and ravuconazole as promising drug candidates for the treatment of eumycetoma.
    PLoS neglected tropical diseases, 2022, Volume: 16, Issue:2

    Topics: Acetamides; Animals; Antifungal Agents; Ascomycota; Drug Discovery; Drug Evaluation, Preclinical; Fenbendazole; Madurella; Moths; Mycetoma; Neglected Diseases; Piperazines; Pyrimidines; Pyrroles; Thiazoles; Triazoles

2022
Eumycetoma causative agents are inhibited in vitro by luliconazole, lanoconazole and ravuconazole.
    Mycoses, 2022, Volume: 65, Issue:6

    Topics: Antifungal Agents; Humans; Imidazoles; Itraconazole; Madurella; Mycetoma; Thiazoles; Triazoles

2022
Epidemiological cut-off values for itraconazole and ravuconazole for Madurella mycetomatis, the most common causative agent of mycetoma.
    Mycoses, 2022, Volume: 65, Issue:12

    Topics: Antifungal Agents; Humans; Itraconazole; Madurella; Mycetoma; Triazoles

2022