Compounds > n-(4-ethylphenyl)-2-((4-ethyl-5-(3-pyridinyl)-4h-1,2,4-triazol-3-yl)thio)acetamide
Page last updated: 2024-12-09

n-(4-ethylphenyl)-2-((4-ethyl-5-(3-pyridinyl)-4h-1,2,4-triazol-3-yl)thio)acetamide

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Description

N-(4-ethylphenyl)-2-((4-ethyl-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl)thio)acetamide: an agonist of orphan receptor ion channel Orco; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID1319135
SCHEMBL ID13737257
MeSH IDM0574257

Synonyms (23)

Synonym
EU-0047517
n-(4-ethylphenyl)-2-{[4-ethyl-5-(pyridin-3-yl)-4h-1,2,4-triazol-3-yl]sulfanyl}acetamide
STK047588
AKOS001657580
n-(4-ethylphenyl)-2-[(4-ethyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide
2-{[4-ethyl-5-(pyridin-3-yl)-4h-1,2,4-triazol-3-yl]sulfanyl}-n-(4-ethylphenyl)acetamide
vuaa1
UWCCKVJVOHTHAF-UHFFFAOYSA-N
2-((4-ethyl-5-(pyridin-3-yl)-4h-1,2,4-triazol-3-yl)thio)-n-(4-ethylphenyl)acetamide
SCHEMBL13737257
525582-84-7
vuaa1, >=98% (hplc)
AS-16599
Q6624995
n-(4-ethylphenyl)-2-((4-ethyl-5-(3-pyridinyl)-4h-1,2,4-triazol-3-yl)thio)acetamide
A900302
DTXSID401029734
n-(4-ethylphenyl)-2-{[4-ethyl-5-(3-pyridinyl)-4h-1,2,4-triazol-3-yl]sulfanyl}acetamide
zz52us95lq ,
unii-zz52us95lq
acetamide, n-(4-ethylphenyl)-2-((4-ethyl-5-(3-pyridinyl)-4h-1,2,4-triazol-3-yl)thio)-
2-((4-ethyl-5-(pyridin-3-yl)-4h-1,2,4-triazol-3-yl)sulfanyl)-n-(4-ethylphenyl)acetamide
salor-int l368539-1ea
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's13 (86.67)24.3611
2020's2 (13.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.79

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.79 (24.57)
Research Supply Index2.77 (2.92)
Research Growth Index4.56 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.79)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
deet
N,N-diethyl-m-toluamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of m-toluic acid with the nitrogen of diethylamine. First developed by the U.S. Army in 1946 for use by military personnel in insect-infested areas, it is the most widely used insect repellent worldwide.		2.3110benzamides;
monocarboxylic acid amide		environmental contaminant;
insect repellent;
xenobiotic
w 7
W 7: RN given refers to parent cpd; structure; calmodulin antagonist		2.110
amiloride
Amiloride: A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705). amiloride : A member of the class of pyrazines resulting from the formal monoacylation of guanidine with the carboxy group of 3,5-diamino-6-chloropyrazine-2-carboxylic acid.		2.0810aromatic amine;
guanidines;
organochlorine compound;
pyrazines		diuretic;
sodium channel blocker
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		4.181501,2,3-triazole
thiourea
Thiourea: A photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.. thiourea : The simplest member of the thiourea class, consisting of urea with the oxygen atom substituted by sulfur.		2.110one-carbon compound;
thioureas;
ureas		antioxidant;
chromophore
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		2.110cysteiniumfundamental metabolite
kb r7943
2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate: inhibits the reverse mode of Na+/Ca++ exchange in cells expressing NCX1; structure in first source		2.110
ConditionIndicatedRelationship StrengthStudiesTrials