Page last updated: 2024-12-05

1,1'-binaphthyl

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1,1'-Binaphthyl is a chiral molecule with a rigid structure and a large dihedral angle between the two naphthyl units. Its unique properties have made it a versatile building block in organic synthesis and a powerful chiral catalyst. The synthesis of 1,1'-binaphthyl typically involves the dimerization of naphthalene or the coupling of two naphthyl units. Notably, 1,1'-binaphthyl derivatives are known for their diverse applications, including:

- Chiral ligands in asymmetric catalysis: Many chiral ligands based on 1,1'-binaphthyl, such as BINAP and its derivatives, are highly effective in promoting enantioselective reactions. Their rigid structure and the presence of multiple chiral centers contribute to their high enantioselectivity.
- Chiral recognition: 1,1'-binaphthyl derivatives can be used as chiral selectors in chromatography and other analytical techniques for separating enantiomers.
- Liquid crystals: Some derivatives of 1,1'-binaphthyl exhibit liquid crystal properties, making them suitable for use in displays and other optoelectronic devices.
- Organic materials: The planar structure of 1,1'-binaphthyl enables it to form stable pi-stacked structures, which are important in organic electronics.
- Pharmaceuticals: Several 1,1'-binaphthyl derivatives have been investigated as potential drug candidates for treating various diseases.

Research on 1,1'-binaphthyl and its derivatives is driven by its versatile applications and the ongoing effort to develop novel chiral catalysts, materials, and drugs with improved properties.

1,1'-binaphthyl: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11789
MeSH IDM0368402

Synonyms (49)

Synonym
1-(1-naphthyl)naphthalene
AC-4950
nsc 15230
t87t28s609 ,
ai3-18146
einecs 210-070-6
di-alpha-naphthol
unii-t87t28s609
nsc-662279
nsc662279
nsc15230
1,1'-dinaphthyl
604-53-5
nsc-15230
1,1'-binaphthyl
1,1'-binaphthalene
di-.alpha.-naphthol
inchi=1/c20h14/c1-3-11-17-15(7-1)9-5-13-19(17)20-14-6-10-16-8-2-4-12-18(16)20/h1-14
B0805
AKOS000352081
1-naphthalen-1-ylnaphthalene
11068-27-2
binaphthalene
1-naphthalen-1-ylnaphthalin
1-(naphthalen-1-yl)naphthalene
binaphthyl
FT-0606058
(+/-)-binaphthyl
.alpha.,.alpha.'-binaphthyl
1,1'-binaphtyl
.alpha.,.alpha.'-dinaphthylene
mfcd00041740
1,1'-binaphthyl, 98%
1,1pr-binaphthyl
(+/-)-1,1'-binaphthyl
DTXSID70870671
SY037129
1,1 inverted exclamation mark -binaphthyl
AS-14353
AMY13703
OL10142
Q27289804
1,1/'-binaphthyl
i+/-,.i+/-'-binaphthyl
1,1-binaphthyl
1-(naphthalen-1-yl)naphthalene;1,1'-binaphthalene
A851185
PB47311
CS-W014087
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (45)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (17.78)29.6817
2010's30 (66.67)24.3611
2020's7 (15.56)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 33.49

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index33.49 (24.57)
Research Supply Index3.83 (2.92)
Research Growth Index5.63 (4.65)
Search Engine Demand Index39.93 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (33.49)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (4.44%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other43 (95.56%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]