Page last updated: 2024-08-24

triazoles and ergosterol

triazoles has been researched along with ergosterol in 60 studies

Research

Studies (60)

TimeframeStudies, this research(%)All Research%
pre-19902 (3.33)18.7374
1990's12 (20.00)18.2507
2000's12 (20.00)29.6817
2010's29 (48.33)24.3611
2020's5 (8.33)2.80

Authors

AuthorsStudies
Marichal, P; Vanden Bossche, H1
Barrett-Bee, K; Newboult, L; Pinder, P1
Aguirre, T; Lazardi, K; Piras, MM; Piras, R; Urbina, JA1
de Souza, W; Lazardi, K; Urbina, JA1
Ryder, NS1
Berg, D; Büchel, KH; Plempel, M; Zywietz, A1
Barrett-Bee, KJ; Ryley, JF; Wilson, RG1
Bartlett, MS; Queener, SF; Richardson, JD; Shaw, MM; Smith, JW1
Hiratani, T; Yamaguchi, H1
Maldonado, RA; Molina, J; Payares, G; Urbina, JA1
Denning, DW; Kelly, SL; Manning, NJ; Venkateswarlu, K1
Kelly, SL; Venkateswarlu, K1
Baldwin, BC; Kelly, SL; Kwon-Chung, KJ; Lamb, DC1
Denning, DW; Kelly, SL; Venkateswarlu, K1
Chung, SK; Kang, HI; Kudo, M; Lee, KW; Yamashita, C; Yoshida, Y1
DiDomenico, B; Greene, J; Hare, R; Heimark, L; Munayyer, H; Pramanik, BN; Shipkova, P; Yarosh-Tomaine, T1
Amon, A; Favre, B; Gössnitzer, E; Punkenhofer, A1
Ausma, J; Bohets, H; Borgers, M; Marichal, P; Meerpoel, L; Odds, F; Vanden Bossche, H; Vermuyten, K; Willemsens, G1
Chau, AS; Greene, JR; Hare, RS; Heimark, L; Loebenberg, D; Mann, PA; McNicholas, PM; Munayyer, HK; Palermo, RE; Yarosh-Tomaine, T1
Han, XY; Hassan, SA; Matsuda, SP; May, GS; Tarrand, JJ; Wilson, WK; Xiong, Q1
Basombrío, MA; Cardozo, R; Corrales, M; Segura, MA; Urbina, JA1
Benaim, G; Burgos, JM; Caldera, AR; Colina, C; Concepcion, JL; Garcia-Marchán, Y; Leon-Rossell, A; Levin, M; Lira, R; Oldfield, E; Payares, G; Sanders, JM; Sanoja, C; Schijman, AG; Urbina, JA1
Almeida, D; de Nazareth S L de Meirelles, M; Pereira, MC; Silva, DT; Urbina, JA1
Abdala-Valencia, H; Le Baut, G; Le Borgne, M; Le Pape, P; Marchand, P; Pagniez, F; Robert-Piessard, S1
Chau, AS; Chen, G; Mann, PA; McNicholas, PM1
Baird, TD; DeLorenzo, ME1
Costa-de-Oliveira, S; Pina-Vaz, C; Pinto e Silva, AT; Rodrigues, AG; Silva-Dias, A1
Bader, O; Gross, U; Kelly, DE; Kelly, SL; Martel, CM; Parker, JE; Rolley, N; Warrilow, AG; Weig, M1
Kelly, DE; Kelly, SL; Martel, CM; Parker, JE; Rolley, NJ; Warrilow, AG1
Cools, HJ; Fraaije, BA; Kelly, DE; Kelly, SL; Lucas, JA; Martel, CM; Nes, WD; Parker, JE; Warrilow, AG1
Blosser, SJ; Cramer, RA1
Alcazar-Fuoli, L; Bignell, E; Blatzer, M; Cairns, T; Grimalt, JO; Gründlinger, M; Haas, H; Lopez, JF; Puempel, T; Yasmin, S1
Barker, BM; Beckmann, N; Blatzer, M; Blosser, SJ; Cornish, EJ; Cramer, RA; Grahl, N; Haas, H; Mazurie, A; Willger, SD1
Kontoyiannis, DP; Lewis, RE; Lortholary, O; Roilides, E; Spellberg, B; Walsh, TJ1
Bader, O; Gross, U; Hull, CM; Kelly, DE; Kelly, SL; Parker, JE; Warrilow, AG; Weig, M1
Cabral, ME; Fariña, JI; Figueroa, LI1
Inui, F; Iwata, A; Kangawa, Y; Nagashima, M; Nishiyama, Y; Pillai, R; Shibanushi, T; Siu, WJ; Tatsumi, Y1
Averette, AF; Chen, YL; Heitman, J; Lehman, VN; Perfect, JR1
Noël, T1
Coste, A; Eddouzi, J; Ischer, F; Kelly, S; Manai, M; Parker, JE; Sanglard, D; Vale-Silva, LA1
Chen, Y; Dawood, DH; Liu, X; Ma, Z; Yin, D; Yun, Y1
Gupta, AK; Simpson, FC1
Coutinho, EC; Khedkar, V; Mohanraj, K; Shah, JJ1
Ganesh Kumar, C; Hussaini, SM; Kamal, A; Poornachandra, Y; Sucharitha, ML; Sultana, F1
de Macedo-Silva, ST; de Souza, W; Rodrigues, JC; Urbina, JA; Visbal, G1
Alencar, LP; Bandeira, SP; Bandeira, TJ; Brandine, GS; Brilhante, RS; Castelo-Branco, DS; Cordeiro, RA; Guedes, GM; Melo, LM; Moreira, JL; Paiva, MA; Pereira-Neto, WA; Ponte, YB; Rocha, MF; Sales, JA; Sidrim, JJ1
Bolton, MD; de Jonge, R; Ebert, MK; Faino, L; Rivera-Varas, V; Secor, GA; Thomma, BP; Van de Peer, Y1
Bonhivers, M; Courtois, P; Dacheux, D; Dauchy, FA; Daulouède, S; Landrein, N; Lauruol, F; Robinson, DR; Vincendeau, P1
Albert, ND; Heo, ST; Jiang, Y; Jiménez-Ortigosa, C; Kontoyiannis, DP; Lewis, RE; Meis, JF; Mikos, AG; Perlin, DS; Tarrand, J; Tatara, AM; Tverdek, F; Verweij, PE1
Fitt, BDL; Fraaije, B; Hawkins, NJ; Huang, Y; Kelly, DE; Kelly, SL; Sewell, TR; Stotz, HU1
Binder, U; Bracher, F; Lass-Flörl, C; Müller, C; Neugebauer, T; Zill, P1
Cotillo, I; De Rycker, M; Gray, DW; Lewis, MD; MacLean, LM; Thomas, J1
Keniya, MV; Monk, BC; Ruma, YN; Tyndall, JDA1
Ai, M; Han, J; He, B; Hu, Z; Li, G; Ma, L; Niu, Y; Sun, Y; Zeng, B1
Du, Y; Liu, Y; Pan, X; Qi, Z; Song, T; Yin, X; Yu, J; Yu, M; Zhang, R; Zhou, Y1
Briz-Cid, N; Cancho-Grande, B; Figueiredo-González, M; González-Barreiro, C; Pose-Juan, E; Rial-Otero, R; Sieiro-Sampedro, T; Simal-Gándara, J1
Baschien, C; Baudy, P; Bundschuh, M; Konschak, M; Sakpal, H; Schulz, R; Zubrod, JP1
Castanheira, M; Collingsworth, TD; Davis, AP; Deshpande, LM; Pfaller, MA1
Chai, J; Chen, M; Han, L; Hu, H; Lu, A; Sun, S; Tai, L; Yan, J; Yang, C1
Amich, J; Bin Shuraym, H; Bromley, MJ; Goldman, GH; Gsaller, F; Hemmings, S; Storer, ISR; Valero, C; van Rhijn, N1

Reviews

1 review(s) available for triazoles and ergosterol

ArticleYear
The cellular and molecular defense mechanisms of the Candida yeasts against azole antifungal drugs.
    Journal de mycologie medicale, 2012, Volume: 22, Issue:2

    Topics: Amino Acid Motifs; Aneuploidy; Antifungal Agents; ATP-Binding Cassette Transporters; Biological Transport; Candida; Chromosomes, Fungal; Drug Resistance, Multiple, Fungal; Endoplasmic Reticulum, Smooth; Ergosterol; Fungal Proteins; Gene Duplication; Gene Expression Regulation, Fungal; Genes, Fungal; Haploidy; Isochromosomes; Membrane Lipids; Membrane Transport Proteins; Point Mutation; Protein Binding; Sterol 14-Demethylase; Trans-Activators; Transcription Factors; Triazoles; Up-Regulation

2012

Other Studies

59 other study(ies) available for triazoles and ergosterol

ArticleYear
Mode of action of anti-Candida drugs: focus on terconazole and other ergosterol biosynthesis inhibitors.
    American journal of obstetrics and gynecology, 1991, Volume: 165, Issue:4 Pt 2

    Topics: Antifungal Agents; Candida; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ergosterol; Oxidoreductases; Oxygenases; Squalene Monooxygenase; Sterol 14-Demethylase; Triazoles

1991
Biochemical changes associated with the antifungal action of the triazole ICI 153,066 on Candida albicans and Trichophyton quinckeanum.
    FEMS microbiology letters, 1991, Apr-15, Volume: 63, Issue:2-3

    Topics: Acetates; Acetic Acid; Amino Acids; Antifungal Agents; Candida albicans; Ergosterol; Gas Chromatography-Mass Spectrometry; Lanosterol; Mevalonic Acid; Sterols; Triazoles; Trichophyton

1991
Antiproliferative effects and mechanism of action of ICI 195,739, a novel bis-triazole derivative, on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi.
    Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:4

    Topics: Animals; Cell Division; Chromatography, Gas; Chromatography, Thin Layer; Ergosterol; Naphthalenes; Terbinafine; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells

1991
Ultrastructural alterations induced by ICI 195,739, a bis-triazole derivative with strong antiproliferative action against Trypanosoma (Schizotrypanum) cruzi.
    Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:4

    Topics: Animals; Ergosterol; Ketoconazole; Naphthalenes; Terbinafine; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells

1991
Biochemical mode of action and enantiomeric selectivity of SDZ 89-485, a new triazole antimycotic.
    Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology, 1990, Volume: 28, Issue:5

    Topics: Animals; Antifungal Agents; Aspergillus fumigatus; Autoradiography; Candida albicans; Cholesterol; Dose-Response Relationship, Drug; Ergosterol; Hydrogen-Ion Concentration; Molecular Structure; Oxygen Consumption; Rats; Triazoles; Trichophyton

1990
Action mechanisms of cell-division-arresting benzimidazoles and of sterol biosynthesis-inhibiting imidazoles, 1,2,4-triazoles, and pyrimidines.
    Mykosen, 1986, Volume: 29, Issue:5

    Topics: Benzimidazoles; Cell Division; Ergosterol; Fungi; Imidazoles; Pyrimidines; Sterols; Triazoles; Tubulin

1986
Azole resistance in Candida albicans.
    Sabouraudia, 1984, Volume: 22, Issue:1

    Topics: Amino Acids; Animals; Antifungal Agents; Candida albicans; Candidiasis, Chronic Mucocutaneous; Candidiasis, Vulvovaginal; Drug Resistance, Microbial; Ergosterol; Female; Ketoconazole; Mice; Rats; Triazoles

1984
Pneumocystis carinii is resistant to imidazole antifungal agents.
    Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:8

    Topics: Animals; Antifungal Agents; Ergosterol; Female; Fluconazole; Gas Chromatography-Mass Spectrometry; Itraconazole; Ketoconazole; Miconazole; Pneumocystis; Rats; Rats, Sprague-Dawley; Triazoles

1994
[Cross-resistance of Candida albicans to several different families of antifungals with ergosterol biosynthesis-inhibiting activity].
    The Japanese journal of antibiotics, 1994, Volume: 47, Issue:2

    Topics: Antifungal Agents; Candida albicans; Depression, Chemical; Drug Resistance, Microbial; Ergosterol; Ketoconazole; Morpholines; Naphthalenes; Terbinafine; Triazoles

1994
Experimental chemotherapy with combinations of ergosterol biosynthesis inhibitors in murine models of Chagas' disease.
    Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:6

    Topics: Animals; Antifungal Agents; Chagas Disease; Disease Models, Animal; Ergosterol; Female; Ketoconazole; Mice; Naphthalenes; Terbinafine; Triazoles; Trypanocidal Agents

1993
Comparison of D0870, a new triazole antifungal agent, to fluconazole for inhibition of Candida albicans cytochrome P-450 by using in vitro assays.
    Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:6

    Topics: Antifungal Agents; Candida albicans; Cytochrome P-450 Enzyme System; Ergosterol; Fluconazole; Gas Chromatography-Mass Spectrometry; Humans; Microbial Sensitivity Tests; Microsomes; Structure-Activity Relationship; Triazoles

1996
Stereoselective interaction of SCH 39304, a triazole, with sterol 14alpha-demethylase of Aspergillus fumigatus.
    The Journal of antimicrobial chemotherapy, 1997, Volume: 39, Issue:5

    Topics: Antifungal Agents; Aspergillus fumigatus; Cytochrome P-450 Enzyme System; Ergosterol; Microbial Sensitivity Tests; Oxidoreductases; Stereoisomerism; Sterol 14-Demethylase; Triazoles

1997
Stereoselective interaction of the azole antifungal agent SCH39304 with the cytochrome P-450 monooxygenase system isolated from Cryptococcus neoformans.
    Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:7

    Topics: Antifungal Agents; Cryptococcus neoformans; Cytochrome P-450 Enzyme System; Ergosterol; Humans; Microbial Sensitivity Tests; Microsomes; Stereoisomerism; Triazoles

1997
In-vitro activity of D0870, a new triazole antifungal drug, in comparison with fluconazole and itraconazole against Aspergillus fumigatus and Candida krusei.
    The Journal of antimicrobial chemotherapy, 1997, Volume: 39, Issue:6

    Topics: Antifungal Agents; Aspergillus fumigatus; Candida; Carbon Monoxide; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Ergosterol; Fluconazole; Itraconazole; Time Factors; Triazoles

1997
Design and synthesis of potential inhibitors of the ergosterol biosynthesis as antifungal agents.
    Bioorganic & medicinal chemistry, 2000, Volume: 8, Issue:10

    Topics: Administration, Oral; Animals; Antifungal Agents; Candida albicans; Chromatography, Gas; Chromatography, Thin Layer; Cytochrome P-450 Enzyme Inhibitors; Drug Design; Ergosterol; Imidazoles; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Mice, Inbred ICR; Microsomes; Models, Molecular; Molecular Structure; Oxidoreductases; Rats; Sterol 14-Demethylase; Structure-Activity Relationship; Triazoles

2000
Mechanism of azole antifungal activity as determined by liquid chromatographic/mass spectrometric monitoring of ergosterol biosynthesis.
    Journal of mass spectrometry : JMS, 2002, Volume: 37, Issue:3

    Topics: Antifungal Agents; Azoles; Candida albicans; Chromatography, High Pressure Liquid; Ergosterol; Lanosterol; Spectrometry, Mass, Electrospray Ionization; Sterols; Triazoles

2002
Novel high energy intermediate analogues with triazasterol-related structures as inhibitors of ergosterol biosynthesis. III. Synthesis and antifungal activity of N4-alkyl-1,6,7,11b-tetrahydro-2H-pyrimido[4,3-a]isoquinolin-4-amine salts.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2003, Volume: 19, Issue:2-3

    Topics: Antifungal Agents; Aspergillus fumigatus; Candida albicans; Cryptococcus neoformans; Ergosterol; Isoquinolines; Microbial Sensitivity Tests; Saccharomyces cerevisiae; Structure-Activity Relationship; Triazoles; Trichophyton

2003
The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis.
    Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:9

    Topics: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Adrenal Cortex; Androgens; Animals; Antifungal Agents; Candida albicans; Cattle; Cells, Cultured; Cholesterol; Cytochrome P-450 Enzyme System; Epidermis; Ergosterol; Estrogens; Humans; Imidazoles; In Vitro Techniques; Itraconazole; Kidney; Male; Microsomes; Microsomes, Liver; Microsporum; Mitochondria; Pharmaceutical Preparations; Placenta; Rats; Rats, Wistar; Steroid 11-beta-Hydroxylase; Testis; Tretinoin; Triazoles; Trichophyton

2004
Posaconazole is a potent inhibitor of sterol 14alpha-demethylation in yeasts and molds.
    Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:10

    Topics: Antifungal Agents; Aspergillus flavus; Aspergillus fumigatus; Azoles; Candida glabrata; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ergosterol; Gas Chromatography-Mass Spectrometry; Microbial Sensitivity Tests; Oxidoreductases; Sterol 14-Demethylase; Triazoles

2004
Cholesterol import by Aspergillus fumigatus and its influence on antifungal potency of sterol biosynthesis inhibitors.
    Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:2

    Topics: Antifungal Agents; Aspergillus fumigatus; Azoles; Cell Membrane; Cholesterol; Culture Media, Conditioned; Ergosterol; Humans; Itraconazole; Magnetic Resonance Spectroscopy; Oxygen Consumption; Pyrimidines; Spores, Fungal; Sterols; Triazoles; Voriconazole

2005
Comparative efficacies of TAK-187, a long-lasting ergosterol biosynthesis inhibitor, and benznidazole in preventing cardiac damage in a murine model of Chagas' disease.
    Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:4

    Topics: Acute Disease; Animals; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Ergosterol; Male; Mice; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2005
Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole.
    Journal of medicinal chemistry, 2006, Feb-09, Volume: 49, Issue:3

    Topics: Acute Disease; Amiodarone; Animals; Calcium; Chagas Disease; Chlorocebus aethiops; Crystallography, X-Ray; Drug Synergism; Ergosterol; Intramolecular Transferases; Mice; Models, Molecular; Molecular Structure; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells

2006
Cytoskeleton reassembly in cardiomyocytes infected by Trypanosoma cruzi is triggered by treatment with ergosterol biosynthesis inhibitors.
    International journal of antimicrobial agents, 2006, Volume: 27, Issue:6

    Topics: Animals; Cells, Cultured; Cytoskeleton; Ergosterol; Ketoconazole; Mice; Myocytes, Cardiac; Myofibrils; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2006
Antileishmanial activities and mechanisms of action of indole-based azoles.
    Journal of enzyme inhibition and medicinal chemistry, 2006, Volume: 21, Issue:3

    Topics: Animals; Antiprotozoal Agents; Azoles; Disease Models, Animal; Dose-Response Relationship, Drug; Ergosterol; Imidazoles; Indoles; Interleukin-4; Leishmania major; Leishmania mexicana; Leishmaniasis; Liver; Male; Mice; Mice, Inbred BALB C; Microscopy, Electron, Scanning; Molecular Structure; Parasitic Sensitivity Tests; Phospholipases A; Sensitivity and Specificity; Spleen; Triazoles

2006
Molecular basis for enhanced activity of posaconazole against Absidia corymbifera and Rhizopus oryzae.
    Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:11

    Topics: Absidia; Amino Acid Sequence; Antifungal Agents; Cytochrome P-450 Enzyme System; Ergosterol; Microbial Sensitivity Tests; Molecular Sequence Data; Oxidoreductases; Rhizopus; Saccharomyces cerevisiae; Sterol 14-Demethylase; Triazoles

2006
Descriptive and mechanistic toxicity of conazole fungicides using the model test alga Dunaliella tertiolecta (Chlorophyceae).
    Environmental toxicology, 2010, Volume: 25, Issue:3

    Topics: Cell Membrane; Cell Size; Ergosterol; Fungicides, Industrial; Glycerol; Lethal Dose 50; Membrane Fluidity; Molecular Structure; No-Observed-Adverse-Effect Level; Osmotic Pressure; Toxicity Tests; Triazoles; Volvocida

2010
Dynamics of in vitro acquisition of resistance by Candida parapsilosis to different azoles.
    FEMS yeast research, 2009, Volume: 9, Issue:4

    Topics: Antifungal Agents; Biosynthetic Pathways; Candida; Drug Resistance, Fungal; Ergosterol; Fluconazole; Humans; Microbial Sensitivity Tests; Mutation; Pyrimidines; Triazoles; Voriconazole

2009
Identification and characterization of four azole-resistant erg3 mutants of Candida albicans.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:11

    Topics: Amphotericin B; Antifungal Agents; Azoles; Candida albicans; Clotrimazole; Drug Resistance, Fungal; Ergosterol; Fluconazole; Itraconazole; Ketoconazole; Microbial Sensitivity Tests; Mutation; Oxidoreductases; Pyrimidines; Triazoles; Voriconazole

2010
Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (sterol 14α-demethylase) doxycycline-regulated mutant and screening of the azole sensitivity of Aspergillus fumigatus isoenzymes CYP51A and CYP51B.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:11

    Topics: Anti-Bacterial Agents; Aspergillus fumigatus; Azoles; Clotrimazole; Cytochrome P-450 Enzyme System; Doxycycline; Ergosterol; Fluconazole; Fungal Proteins; Genetic Complementation Test; Itraconazole; Pyrimidines; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Triazoles; Voriconazole

2010
Mechanism of binding of prothioconazole to Mycosphaerella graminicola CYP51 differs from that of other azole antifungals.
    Applied and environmental microbiology, 2011, Volume: 77, Issue:4

    Topics: Ascomycota; Drug Resistance, Fungal; Electrophoresis, Polyacrylamide Gel; Ergosterol; Fungicides, Industrial; Lanosterol; Plant Diseases; Protein Binding; Sterol 14-Demethylase; Triazoles

2011
SREBP-dependent triazole susceptibility in Aspergillus fumigatus is mediated through direct transcriptional regulation of erg11A (cyp51A).
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:1

    Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Ergosterol; Fluconazole; Fungal Proteins; Gene Expression Regulation, Fungal; Genetic Complementation Test; Genotype; Humans; Microbial Sensitivity Tests; Organisms, Genetically Modified; Pyrimidines; Real-Time Polymerase Chain Reaction; Sterol Regulatory Element Binding Proteins; Transcription, Genetic; Triazoles; Voriconazole

2012
Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus.
    Proceedings of the National Academy of Sciences of the United States of America, 2012, Feb-21, Volume: 109, Issue:8

    Topics: Amphotericin B; Animals; Aspergillus fumigatus; Biomass; Biosynthetic Pathways; Enoyl-CoA Hydratase; Ergosterol; Ferric Compounds; Gene Deletion; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Gene Silencing; Genes, Fungal; Hydroxamic Acids; Hydroxymethylglutaryl CoA Reductases; Iron Deficiencies; Ligases; Lovastatin; Mevalonic Acid; Mice; Microbial Sensitivity Tests; Oxidative Stress; Pulmonary Aspergillosis; Pyrimidines; Siderophores; Triazoles; Up-Regulation; Virulence; Voriconazole

2012
SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus.
    PLoS genetics, 2011, Volume: 7, Issue:12

    Topics: Animals; Antifungal Agents; Aspergillus fumigatus; Drug Resistance, Fungal; Ergosterol; Gene Expression Regulation, Fungal; Homeostasis; Humans; Iron; Lung Diseases, Fungal; Mice; Oligonucleotide Array Sequence Analysis; Siderophores; Sterol Regulatory Element Binding Proteins; Triazoles

2011
How does antifungal pharmacology differ for mucormycosis versus aspergillosis?
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2012, Volume: 54 Suppl 1

    Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus; Cell Membrane; Cell Wall; Drug Resistance, Multiple, Fungal; Ergosterol; Gene Duplication; Genome, Fungal; Genomic Instability; Humans; Itraconazole; Microbial Sensitivity Tests; Mucormycosis; Pyrimidines; Rhizopus; Species Specificity; Triazoles; Virulence Factors; Voriconazole

2012
Facultative sterol uptake in an ergosterol-deficient clinical isolate of Candida glabrata harboring a missense mutation in ERG11 and exhibiting cross-resistance to azoles and amphotericin B.
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:8

    Topics: Amphotericin B; Antifungal Agents; Azoles; Base Sequence; Biological Transport; Candida glabrata; Drug Resistance, Multiple, Fungal; Ergosterol; Fluconazole; Fungal Proteins; Humans; Microbial Sensitivity Tests; Mutation, Missense; Pyrimidines; Saccharomyces cerevisiae; Sequence Analysis, DNA; Sterol 14-Demethylase; Sterols; Triazoles; Voriconazole

2012
Synergistic antifungal activity of statin-azole associations as witnessed by Saccharomyces cerevisiae- and Candida utilis-bioassays and ergosterol quantification.
    Revista iberoamericana de micologia, 2013, Jan-03, Volume: 30, Issue:1

    Topics: Antifungal Agents; Candida; Disk Diffusion Antimicrobial Tests; Drug Resistance, Fungal; Drug Synergism; Ergosterol; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Microbial Sensitivity Tests; Saccharomyces cerevisiae; Species Specificity; Triazoles

2013
Mechanism of action of efinaconazole, a novel triazole antifungal agent.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:5

    Topics: 14-alpha Demethylase Inhibitors; Antifungal Agents; Candida albicans; Dose-Response Relationship, Drug; Ergosterol; Hyphae; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Sterols; Triazoles; Trichophyton

2013
Posaconazole exhibits in vitro and in vivo synergistic antifungal activity with caspofungin or FK506 against Candida albicans.
    PloS one, 2013, Volume: 8, Issue:3

    Topics: Animals; Antifungal Agents; Base Sequence; Candida albicans; Candidiasis; Caspofungin; Drug Resistance, Fungal; Drug Synergism; Echinocandins; Ergosterol; Lipopeptides; Male; Mice; Molecular Sequence Data; Mutation; Sequence Homology, Nucleic Acid; Tacrolimus; Triazoles

2013
Molecular mechanisms of drug resistance in clinical Candida species isolated from Tunisian hospitals.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:7

    Topics: Amino Acid Sequence; Amino Acid Substitution; Amphotericin B; Antifungal Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azoles; Base Sequence; Candida albicans; Candida glabrata; Candida tropicalis; Candidiasis; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Ergosterol; Fluconazole; Fungal Proteins; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Mutation; Polyenes; Pyrimidines; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Analysis, DNA; Triazoles; Tunisia; Voriconazole

2013
Functional characterization of FgERG3 and FgERG5 associated with ergosterol biosynthesis, vegetative differentiation and virulence of Fusarium graminearum.
    Fungal genetics and biology : FG & B, 2014, Volume: 68

    Topics: Ergosterol; Fungal Proteins; Fungicides, Industrial; Fusarium; Gene Deletion; Genes, Fungal; Hyphae; Mutation; Oxidative Stress; Paraquat; Spores, Fungal; Triazoles; Triticum; Virulence

2014
Efinaconazole (Jublia) for the treatment of onychomycosis.
    Expert review of anti-infective therapy, 2014, Volume: 12, Issue:7

    Topics: 14-alpha Demethylase Inhibitors; Administration, Topical; Clinical Trials as Topic; Ergosterol; Humans; Microbial Sensitivity Tests; Onychomycosis; Triazoles

2014
Design, synthesis and evaluation of benzotriazole derivatives as novel antifungal agents.
    Bioorganic & medicinal chemistry letters, 2015, Sep-01, Volume: 25, Issue:17

    Topics: 14-alpha Demethylase Inhibitors; Antifungal Agents; Candida albicans; Chemistry Techniques, Synthetic; Drug Design; Drug Evaluation, Preclinical; Ergosterol; Fungal Proteins; Microbial Sensitivity Tests; Molecular Docking Simulation; Spectrophotometry, Ultraviolet; Sterol 14-Demethylase; Structure-Activity Relationship; Tandem Mass Spectrometry; Triazoles

2015
Synthesis and antimicrobial potential of nitrofuran-triazole congeners.
    Organic & biomolecular chemistry, 2015, Sep-28, Volume: 13, Issue:36

    Topics: Anti-Bacterial Agents; Antifungal Agents; Candida; Cell Line; Dose-Response Relationship, Drug; Ergosterol; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Nitrofurans; Structure-Activity Relationship; Triazoles

2015
Potent In Vitro Antiproliferative Synergism of Combinations of Ergosterol Biosynthesis Inhibitors against Leishmania amazonensis.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:10

    Topics: 14-alpha Demethylase Inhibitors; Animals; Culture Media; Drug Synergism; Drug Therapy, Combination; Ergosterol; Farnesyl-Diphosphate Farnesyltransferase; Humans; Itraconazole; Leishmania mexicana; Leishmaniasis, Diffuse Cutaneous; Lipid Droplets; Membrane Potential, Mitochondrial; Mice; Mitochondria; Parasitic Sensitivity Tests; Pyridines; Quinuclidines; Reactive Oxygen Species; Sterol 14-Demethylase; Triazoles; Trypanocidal Agents

2015
Cross-resistance to fluconazole induced by exposure to the agricultural azole tetraconazole: an environmental resistance school?
    Mycoses, 2016, Volume: 59, Issue:5

    Topics: Animals; Anti-Allergic Agents; Antifungal Agents; ATP-Binding Cassette Transporters; Candida; Chlorobenzenes; Drug Resistance, Microbial; Ergosterol; Fluconazole; Fungicides, Industrial; Gene Expression Regulation, Fungal; Humans; Itraconazole; Malathion; Microbial Sensitivity Tests; Promethazine; Rhodamines; Sterol 14-Demethylase; Triazoles; Voriconazole

2016
RNA-sequencing of Cercospora beticola DMI-sensitive and -resistant isolates after treatment with tetraconazole identifies common and contrasting pathway induction.
    Fungal genetics and biology : FG & B, 2016, Volume: 92

    Topics: 14-alpha Demethylase Inhibitors; Ascomycota; Base Sequence; Chlorobenzenes; Drug Resistance, Fungal; Ergosterol; Fungicides, Industrial; High-Throughput Nucleotide Sequencing; Mutation; Sterol 14-Demethylase; Triazoles

2016
Trypanosoma brucei CYP51: Essentiality and Targeting Therapy in an Experimental Model.
    PLoS neglected tropical diseases, 2016, Volume: 10, Issue:11

    Topics: 14-alpha Demethylase Inhibitors; Animals; Anti-Bacterial Agents; Cytokinesis; Disease Models, Animal; Doxycycline; Eflornithine; Ergosterol; Humans; Mice; Nifurtimox; Phenotype; RNA Interference; Sterol 14-Demethylase; Triazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African

2016
Changes in In Vitro Susceptibility Patterns of Aspergillus to Triazoles and Correlation With Aspergillosis Outcome in a Tertiary Care Cancer Center, 1999-2015.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017, Jul-15, Volume: 65, Issue:2

    Topics: Adult; Antifungal Agents; Aspergillosis; Aspergillus; Aspergillus fumigatus; Cohort Studies; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Ergosterol; Female; Fungal Proteins; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Invasive Pulmonary Aspergillosis; Male; Microbial Sensitivity Tests; Polymorphism, Genetic; Prospective Studies; Tertiary Healthcare; Treatment Outcome; Triazoles; Voriconazole; Young Adult

2017
Azole sensitivity in Leptosphaeria pathogens of oilseed rape: the role of lanosterol 14α-demethylase.
    Scientific reports, 2017, Nov-20, Volume: 7, Issue:1

    Topics: Ascomycota; Azoles; Binding Sites; Brassica; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Ergosterol; Fungicides, Industrial; Gene Expression Regulation, Fungal; Silanes; Sterol 14-Demethylase; Triazoles

2017
Sterol Composition of Clinically Relevant Mucorales and Changes Resulting from Posaconazole Treatment.
    Molecules (Basel, Switzerland), 2018, May-19, Volume: 23, Issue:5

    Topics: Antifungal Agents; Aspergillus fumigatus; Drug Resistance, Fungal; Ergosterol; Gas Chromatography-Mass Spectrometry; Metabolomics; Molecular Structure; Mucorales; Species Specificity; Sterols; Triazoles

2018
Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas' disease drug discovery.
    PLoS neglected tropical diseases, 2018, Volume: 12, Issue:7

    Topics: Biological Assay; Chagas Disease; Drug Discovery; Ergosterol; Humans; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2018
Heterologous Expression of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provides Tools for Antifungal Discovery.
    Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:11

    Topics: Amphotericin B; Antifungal Agents; Azoles; Candida albicans; Candida glabrata; Drug Resistance, Fungal; Ergosterol; Fluconazole; Fungal Proteins; Humans; Itraconazole; Lanosterol; Microbial Sensitivity Tests; Saccharomyces cerevisiae; Sterol 14-Demethylase; Triazoles; Voriconazole

2018
Gene transcription profiling of Aspergillus oryzae 3.042 treated with ergosterol biosynthesis inhibitors.
    Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2019, Volume: 50, Issue:1

    Topics: Aspergillus oryzae; Ergosterol; Fungal Proteins; Fungicides, Industrial; Gene Expression Profiling; Gene Expression Regulation, Fungal; Terbinafine; Transcription, Genetic; Triazoles

2019
Characterization of propiconazole field-resistant isolates of Ustilaginoidea virens.
    Pesticide biochemistry and physiology, 2019, Volume: 153

    Topics: Drug Resistance, Fungal; Ergosterol; Fungal Proteins; Fungicides, Industrial; Hypocreales; Oryza; Plant Diseases; Sterol 14-Demethylase; Triazoles

2019
Tetraconazole alters the methionine and ergosterol biosynthesis pathways in Saccharomyces yeasts promoting changes on volatile derived compounds.
    Food research international (Ottawa, Ont.), 2020, Volume: 130

    Topics: Chlorobenzenes; Ergosterol; Fungicides, Industrial; Methionine; Saccharomyces; Triazoles; Volatile Organic Compounds

2020
The Fungicide Tebuconazole Confounds Concentrations of Molecular Biomarkers Estimating Fungal Biomass.
    Bulletin of environmental contamination and toxicology, 2020, Volume: 105, Issue:4

    Topics: Biomarkers; Biomass; Ergosterol; Fungi; Fungicides, Industrial; Triazoles

2020
Isavuconazole nonwildtype Aspergillus fumigatus isolates from a global surveillance study display alterations in multiple genes involved in the ergosterol biosynthesis pathway not previously associated with resistance to other azoles.
    Mycoses, 2021, Volume: 64, Issue:10

    Topics: Antifungal Agents; Aspergillus fumigatus; Azoles; Drug Resistance, Fungal; Ergosterol; Fungal Proteins; Humans; Itraconazole; Microbial Sensitivity Tests; Nitriles; Pyridines; Triazoles; Voriconazole; Whole Genome Sequencing

2021
Novel (Z)/(E)-1,2,4-triazole derivatives containing oxime ether moiety as potential ergosterol biosynthesis inhibitors: design, preparation, antifungal evaluation, and molecular docking.
    Molecular diversity, 2023, Volume: 27, Issue:1

    Topics: Antifungal Agents; Ergosterol; Ether; Ethers; Ethyl Ethers; Molecular Docking Simulation; Oximes; Structure-Activity Relationship; Triazoles

2023
Antagonism of the Azoles to Olorofim and Cross-Resistance Are Governed by Linked Transcriptional Networks in Aspergillus fumigatus.
    mBio, 2022, 12-20, Volume: 13, Issue:6

    Topics: Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Azoles; Drug Resistance, Fungal; Ergosterol; Fungal Proteins; Gene Regulatory Networks; Humans; Microbial Sensitivity Tests; Pyrimidines; Transcription Factors; Triazoles

2022