triazoles has been researched along with ergosterol in 60 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.33) | 18.7374 |
| 1990's | 12 (20.00) | 18.2507 |
| 2000's | 12 (20.00) | 29.6817 |
| 2010's | 29 (48.33) | 24.3611 |
| 2020's | 5 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Marichal, P; Vanden Bossche, H | 1 |
| Barrett-Bee, K; Newboult, L; Pinder, P | 1 |
| Aguirre, T; Lazardi, K; Piras, MM; Piras, R; Urbina, JA | 1 |
| de Souza, W; Lazardi, K; Urbina, JA | 1 |
| Ryder, NS | 1 |
| Berg, D; Büchel, KH; Plempel, M; Zywietz, A | 1 |
| Barrett-Bee, KJ; Ryley, JF; Wilson, RG | 1 |
| Bartlett, MS; Queener, SF; Richardson, JD; Shaw, MM; Smith, JW | 1 |
| Hiratani, T; Yamaguchi, H | 1 |
| Maldonado, RA; Molina, J; Payares, G; Urbina, JA | 1 |
| Denning, DW; Kelly, SL; Manning, NJ; Venkateswarlu, K | 1 |
| Kelly, SL; Venkateswarlu, K | 1 |
| Baldwin, BC; Kelly, SL; Kwon-Chung, KJ; Lamb, DC | 1 |
| Denning, DW; Kelly, SL; Venkateswarlu, K | 1 |
| Chung, SK; Kang, HI; Kudo, M; Lee, KW; Yamashita, C; Yoshida, Y | 1 |
| DiDomenico, B; Greene, J; Hare, R; Heimark, L; Munayyer, H; Pramanik, BN; Shipkova, P; Yarosh-Tomaine, T | 1 |
| Amon, A; Favre, B; Gössnitzer, E; Punkenhofer, A | 1 |
| Ausma, J; Bohets, H; Borgers, M; Marichal, P; Meerpoel, L; Odds, F; Vanden Bossche, H; Vermuyten, K; Willemsens, G | 1 |
| Chau, AS; Greene, JR; Hare, RS; Heimark, L; Loebenberg, D; Mann, PA; McNicholas, PM; Munayyer, HK; Palermo, RE; Yarosh-Tomaine, T | 1 |
| Han, XY; Hassan, SA; Matsuda, SP; May, GS; Tarrand, JJ; Wilson, WK; Xiong, Q | 1 |
| Basombrío, MA; Cardozo, R; Corrales, M; Segura, MA; Urbina, JA | 1 |
| Benaim, G; Burgos, JM; Caldera, AR; Colina, C; Concepcion, JL; Garcia-Marchán, Y; Leon-Rossell, A; Levin, M; Lira, R; Oldfield, E; Payares, G; Sanders, JM; Sanoja, C; Schijman, AG; Urbina, JA | 1 |
| Almeida, D; de Nazareth S L de Meirelles, M; Pereira, MC; Silva, DT; Urbina, JA | 1 |
| Abdala-Valencia, H; Le Baut, G; Le Borgne, M; Le Pape, P; Marchand, P; Pagniez, F; Robert-Piessard, S | 1 |
| Chau, AS; Chen, G; Mann, PA; McNicholas, PM | 1 |
| Baird, TD; DeLorenzo, ME | 1 |
| Costa-de-Oliveira, S; Pina-Vaz, C; Pinto e Silva, AT; Rodrigues, AG; Silva-Dias, A | 1 |
| Bader, O; Gross, U; Kelly, DE; Kelly, SL; Martel, CM; Parker, JE; Rolley, N; Warrilow, AG; Weig, M | 1 |
| Kelly, DE; Kelly, SL; Martel, CM; Parker, JE; Rolley, NJ; Warrilow, AG | 1 |
| Cools, HJ; Fraaije, BA; Kelly, DE; Kelly, SL; Lucas, JA; Martel, CM; Nes, WD; Parker, JE; Warrilow, AG | 1 |
| Blosser, SJ; Cramer, RA | 1 |
| Alcazar-Fuoli, L; Bignell, E; Blatzer, M; Cairns, T; Grimalt, JO; Gründlinger, M; Haas, H; Lopez, JF; Puempel, T; Yasmin, S | 1 |
| Barker, BM; Beckmann, N; Blatzer, M; Blosser, SJ; Cornish, EJ; Cramer, RA; Grahl, N; Haas, H; Mazurie, A; Willger, SD | 1 |
| Kontoyiannis, DP; Lewis, RE; Lortholary, O; Roilides, E; Spellberg, B; Walsh, TJ | 1 |
| Bader, O; Gross, U; Hull, CM; Kelly, DE; Kelly, SL; Parker, JE; Warrilow, AG; Weig, M | 1 |
| Cabral, ME; Fariña, JI; Figueroa, LI | 1 |
| Inui, F; Iwata, A; Kangawa, Y; Nagashima, M; Nishiyama, Y; Pillai, R; Shibanushi, T; Siu, WJ; Tatsumi, Y | 1 |
| Averette, AF; Chen, YL; Heitman, J; Lehman, VN; Perfect, JR | 1 |
| Noël, T | 1 |
| Coste, A; Eddouzi, J; Ischer, F; Kelly, S; Manai, M; Parker, JE; Sanglard, D; Vale-Silva, LA | 1 |
| Chen, Y; Dawood, DH; Liu, X; Ma, Z; Yin, D; Yun, Y | 1 |
| Gupta, AK; Simpson, FC | 1 |
| Coutinho, EC; Khedkar, V; Mohanraj, K; Shah, JJ | 1 |
| Ganesh Kumar, C; Hussaini, SM; Kamal, A; Poornachandra, Y; Sucharitha, ML; Sultana, F | 1 |
| de Macedo-Silva, ST; de Souza, W; Rodrigues, JC; Urbina, JA; Visbal, G | 1 |
| Alencar, LP; Bandeira, SP; Bandeira, TJ; Brandine, GS; Brilhante, RS; Castelo-Branco, DS; Cordeiro, RA; Guedes, GM; Melo, LM; Moreira, JL; Paiva, MA; Pereira-Neto, WA; Ponte, YB; Rocha, MF; Sales, JA; Sidrim, JJ | 1 |
| Bolton, MD; de Jonge, R; Ebert, MK; Faino, L; Rivera-Varas, V; Secor, GA; Thomma, BP; Van de Peer, Y | 1 |
| Bonhivers, M; Courtois, P; Dacheux, D; Dauchy, FA; Daulouède, S; Landrein, N; Lauruol, F; Robinson, DR; Vincendeau, P | 1 |
| Albert, ND; Heo, ST; Jiang, Y; Jiménez-Ortigosa, C; Kontoyiannis, DP; Lewis, RE; Meis, JF; Mikos, AG; Perlin, DS; Tarrand, J; Tatara, AM; Tverdek, F; Verweij, PE | 1 |
| Fitt, BDL; Fraaije, B; Hawkins, NJ; Huang, Y; Kelly, DE; Kelly, SL; Sewell, TR; Stotz, HU | 1 |
| Binder, U; Bracher, F; Lass-Flörl, C; Müller, C; Neugebauer, T; Zill, P | 1 |
| Cotillo, I; De Rycker, M; Gray, DW; Lewis, MD; MacLean, LM; Thomas, J | 1 |
| Keniya, MV; Monk, BC; Ruma, YN; Tyndall, JDA | 1 |
| Ai, M; Han, J; He, B; Hu, Z; Li, G; Ma, L; Niu, Y; Sun, Y; Zeng, B | 1 |
| Du, Y; Liu, Y; Pan, X; Qi, Z; Song, T; Yin, X; Yu, J; Yu, M; Zhang, R; Zhou, Y | 1 |
| Briz-Cid, N; Cancho-Grande, B; Figueiredo-González, M; González-Barreiro, C; Pose-Juan, E; Rial-Otero, R; Sieiro-Sampedro, T; Simal-Gándara, J | 1 |
| Baschien, C; Baudy, P; Bundschuh, M; Konschak, M; Sakpal, H; Schulz, R; Zubrod, JP | 1 |
| Castanheira, M; Collingsworth, TD; Davis, AP; Deshpande, LM; Pfaller, MA | 1 |
| Chai, J; Chen, M; Han, L; Hu, H; Lu, A; Sun, S; Tai, L; Yan, J; Yang, C | 1 |
| Amich, J; Bin Shuraym, H; Bromley, MJ; Goldman, GH; Gsaller, F; Hemmings, S; Storer, ISR; Valero, C; van Rhijn, N | 1 |
1 review(s) available for triazoles and ergosterol
| Article | Year |
|---|---|
The cellular and molecular defense mechanisms of the Candida yeasts against azole antifungal drugs.
Topics: Amino Acid Motifs; Aneuploidy; Antifungal Agents; ATP-Binding Cassette Transporters; Biological Transport; Candida; Chromosomes, Fungal; Drug Resistance, Multiple, Fungal; Endoplasmic Reticulum, Smooth; Ergosterol; Fungal Proteins; Gene Duplication; Gene Expression Regulation, Fungal; Genes, Fungal; Haploidy; Isochromosomes; Membrane Lipids; Membrane Transport Proteins; Point Mutation; Protein Binding; Sterol 14-Demethylase; Trans-Activators; Transcription Factors; Triazoles; Up-Regulation | 2012 |
59 other study(ies) available for triazoles and ergosterol
| Article | Year |
|---|---|
Mode of action of anti-Candida drugs: focus on terconazole and other ergosterol biosynthesis inhibitors.
Topics: Antifungal Agents; Candida; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ergosterol; Oxidoreductases; Oxygenases; Squalene Monooxygenase; Sterol 14-Demethylase; Triazoles | 1991 |
Biochemical changes associated with the antifungal action of the triazole ICI 153,066 on Candida albicans and Trichophyton quinckeanum.
Topics: Acetates; Acetic Acid; Amino Acids; Antifungal Agents; Candida albicans; Ergosterol; Gas Chromatography-Mass Spectrometry; Lanosterol; Mevalonic Acid; Sterols; Triazoles; Trichophyton | 1991 |
Antiproliferative effects and mechanism of action of ICI 195,739, a novel bis-triazole derivative, on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi.
Topics: Animals; Cell Division; Chromatography, Gas; Chromatography, Thin Layer; Ergosterol; Naphthalenes; Terbinafine; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 1991 |
Ultrastructural alterations induced by ICI 195,739, a bis-triazole derivative with strong antiproliferative action against Trypanosoma (Schizotrypanum) cruzi.
Topics: Animals; Ergosterol; Ketoconazole; Naphthalenes; Terbinafine; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 1991 |
Biochemical mode of action and enantiomeric selectivity of SDZ 89-485, a new triazole antimycotic.
Topics: Animals; Antifungal Agents; Aspergillus fumigatus; Autoradiography; Candida albicans; Cholesterol; Dose-Response Relationship, Drug; Ergosterol; Hydrogen-Ion Concentration; Molecular Structure; Oxygen Consumption; Rats; Triazoles; Trichophyton | 1990 |
Action mechanisms of cell-division-arresting benzimidazoles and of sterol biosynthesis-inhibiting imidazoles, 1,2,4-triazoles, and pyrimidines.
Topics: Benzimidazoles; Cell Division; Ergosterol; Fungi; Imidazoles; Pyrimidines; Sterols; Triazoles; Tubulin | 1986 |
Azole resistance in Candida albicans.
Topics: Amino Acids; Animals; Antifungal Agents; Candida albicans; Candidiasis, Chronic Mucocutaneous; Candidiasis, Vulvovaginal; Drug Resistance, Microbial; Ergosterol; Female; Ketoconazole; Mice; Rats; Triazoles | 1984 |
Pneumocystis carinii is resistant to imidazole antifungal agents.
Topics: Animals; Antifungal Agents; Ergosterol; Female; Fluconazole; Gas Chromatography-Mass Spectrometry; Itraconazole; Ketoconazole; Miconazole; Pneumocystis; Rats; Rats, Sprague-Dawley; Triazoles | 1994 |
[Cross-resistance of Candida albicans to several different families of antifungals with ergosterol biosynthesis-inhibiting activity].
Topics: Antifungal Agents; Candida albicans; Depression, Chemical; Drug Resistance, Microbial; Ergosterol; Ketoconazole; Morpholines; Naphthalenes; Terbinafine; Triazoles | 1994 |
Experimental chemotherapy with combinations of ergosterol biosynthesis inhibitors in murine models of Chagas' disease.
Topics: Animals; Antifungal Agents; Chagas Disease; Disease Models, Animal; Ergosterol; Female; Ketoconazole; Mice; Naphthalenes; Terbinafine; Triazoles; Trypanocidal Agents | 1993 |
Comparison of D0870, a new triazole antifungal agent, to fluconazole for inhibition of Candida albicans cytochrome P-450 by using in vitro assays.
Topics: Antifungal Agents; Candida albicans; Cytochrome P-450 Enzyme System; Ergosterol; Fluconazole; Gas Chromatography-Mass Spectrometry; Humans; Microbial Sensitivity Tests; Microsomes; Structure-Activity Relationship; Triazoles | 1996 |
Stereoselective interaction of SCH 39304, a triazole, with sterol 14alpha-demethylase of Aspergillus fumigatus.
Topics: Antifungal Agents; Aspergillus fumigatus; Cytochrome P-450 Enzyme System; Ergosterol; Microbial Sensitivity Tests; Oxidoreductases; Stereoisomerism; Sterol 14-Demethylase; Triazoles | 1997 |
Stereoselective interaction of the azole antifungal agent SCH39304 with the cytochrome P-450 monooxygenase system isolated from Cryptococcus neoformans.
Topics: Antifungal Agents; Cryptococcus neoformans; Cytochrome P-450 Enzyme System; Ergosterol; Humans; Microbial Sensitivity Tests; Microsomes; Stereoisomerism; Triazoles | 1997 |
In-vitro activity of D0870, a new triazole antifungal drug, in comparison with fluconazole and itraconazole against Aspergillus fumigatus and Candida krusei.
Topics: Antifungal Agents; Aspergillus fumigatus; Candida; Carbon Monoxide; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Ergosterol; Fluconazole; Itraconazole; Time Factors; Triazoles | 1997 |
Design and synthesis of potential inhibitors of the ergosterol biosynthesis as antifungal agents.
Topics: Administration, Oral; Animals; Antifungal Agents; Candida albicans; Chromatography, Gas; Chromatography, Thin Layer; Cytochrome P-450 Enzyme Inhibitors; Drug Design; Ergosterol; Imidazoles; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Mice, Inbred ICR; Microsomes; Models, Molecular; Molecular Structure; Oxidoreductases; Rats; Sterol 14-Demethylase; Structure-Activity Relationship; Triazoles | 2000 |
Mechanism of azole antifungal activity as determined by liquid chromatographic/mass spectrometric monitoring of ergosterol biosynthesis.
Topics: Antifungal Agents; Azoles; Candida albicans; Chromatography, High Pressure Liquid; Ergosterol; Lanosterol; Spectrometry, Mass, Electrospray Ionization; Sterols; Triazoles | 2002 |
Novel high energy intermediate analogues with triazasterol-related structures as inhibitors of ergosterol biosynthesis. III. Synthesis and antifungal activity of N4-alkyl-1,6,7,11b-tetrahydro-2H-pyrimido[4,3-a]isoquinolin-4-amine salts.
Topics: Antifungal Agents; Aspergillus fumigatus; Candida albicans; Cryptococcus neoformans; Ergosterol; Isoquinolines; Microbial Sensitivity Tests; Saccharomyces cerevisiae; Structure-Activity Relationship; Triazoles; Trichophyton | 2003 |
The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis.
Topics: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Adrenal Cortex; Androgens; Animals; Antifungal Agents; Candida albicans; Cattle; Cells, Cultured; Cholesterol; Cytochrome P-450 Enzyme System; Epidermis; Ergosterol; Estrogens; Humans; Imidazoles; In Vitro Techniques; Itraconazole; Kidney; Male; Microsomes; Microsomes, Liver; Microsporum; Mitochondria; Pharmaceutical Preparations; Placenta; Rats; Rats, Wistar; Steroid 11-beta-Hydroxylase; Testis; Tretinoin; Triazoles; Trichophyton | 2004 |
Posaconazole is a potent inhibitor of sterol 14alpha-demethylation in yeasts and molds.
Topics: Antifungal Agents; Aspergillus flavus; Aspergillus fumigatus; Azoles; Candida glabrata; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ergosterol; Gas Chromatography-Mass Spectrometry; Microbial Sensitivity Tests; Oxidoreductases; Sterol 14-Demethylase; Triazoles | 2004 |
Cholesterol import by Aspergillus fumigatus and its influence on antifungal potency of sterol biosynthesis inhibitors.
Topics: Antifungal Agents; Aspergillus fumigatus; Azoles; Cell Membrane; Cholesterol; Culture Media, Conditioned; Ergosterol; Humans; Itraconazole; Magnetic Resonance Spectroscopy; Oxygen Consumption; Pyrimidines; Spores, Fungal; Sterols; Triazoles; Voriconazole | 2005 |
Comparative efficacies of TAK-187, a long-lasting ergosterol biosynthesis inhibitor, and benznidazole in preventing cardiac damage in a murine model of Chagas' disease.
Topics: Acute Disease; Animals; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Ergosterol; Male; Mice; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2005 |
Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole.
Topics: Acute Disease; Amiodarone; Animals; Calcium; Chagas Disease; Chlorocebus aethiops; Crystallography, X-Ray; Drug Synergism; Ergosterol; Intramolecular Transferases; Mice; Models, Molecular; Molecular Structure; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2006 |
Cytoskeleton reassembly in cardiomyocytes infected by Trypanosoma cruzi is triggered by treatment with ergosterol biosynthesis inhibitors.
Topics: Animals; Cells, Cultured; Cytoskeleton; Ergosterol; Ketoconazole; Mice; Myocytes, Cardiac; Myofibrils; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2006 |
Antileishmanial activities and mechanisms of action of indole-based azoles.
Topics: Animals; Antiprotozoal Agents; Azoles; Disease Models, Animal; Dose-Response Relationship, Drug; Ergosterol; Imidazoles; Indoles; Interleukin-4; Leishmania major; Leishmania mexicana; Leishmaniasis; Liver; Male; Mice; Mice, Inbred BALB C; Microscopy, Electron, Scanning; Molecular Structure; Parasitic Sensitivity Tests; Phospholipases A; Sensitivity and Specificity; Spleen; Triazoles | 2006 |
Molecular basis for enhanced activity of posaconazole against Absidia corymbifera and Rhizopus oryzae.
Topics: Absidia; Amino Acid Sequence; Antifungal Agents; Cytochrome P-450 Enzyme System; Ergosterol; Microbial Sensitivity Tests; Molecular Sequence Data; Oxidoreductases; Rhizopus; Saccharomyces cerevisiae; Sterol 14-Demethylase; Triazoles | 2006 |
Descriptive and mechanistic toxicity of conazole fungicides using the model test alga Dunaliella tertiolecta (Chlorophyceae).
Topics: Cell Membrane; Cell Size; Ergosterol; Fungicides, Industrial; Glycerol; Lethal Dose 50; Membrane Fluidity; Molecular Structure; No-Observed-Adverse-Effect Level; Osmotic Pressure; Toxicity Tests; Triazoles; Volvocida | 2010 |
Dynamics of in vitro acquisition of resistance by Candida parapsilosis to different azoles.
Topics: Antifungal Agents; Biosynthetic Pathways; Candida; Drug Resistance, Fungal; Ergosterol; Fluconazole; Humans; Microbial Sensitivity Tests; Mutation; Pyrimidines; Triazoles; Voriconazole | 2009 |
Identification and characterization of four azole-resistant erg3 mutants of Candida albicans.
Topics: Amphotericin B; Antifungal Agents; Azoles; Candida albicans; Clotrimazole; Drug Resistance, Fungal; Ergosterol; Fluconazole; Itraconazole; Ketoconazole; Microbial Sensitivity Tests; Mutation; Oxidoreductases; Pyrimidines; Triazoles; Voriconazole | 2010 |
Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (sterol 14α-demethylase) doxycycline-regulated mutant and screening of the azole sensitivity of Aspergillus fumigatus isoenzymes CYP51A and CYP51B.
Topics: Anti-Bacterial Agents; Aspergillus fumigatus; Azoles; Clotrimazole; Cytochrome P-450 Enzyme System; Doxycycline; Ergosterol; Fluconazole; Fungal Proteins; Genetic Complementation Test; Itraconazole; Pyrimidines; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Triazoles; Voriconazole | 2010 |
Mechanism of binding of prothioconazole to Mycosphaerella graminicola CYP51 differs from that of other azole antifungals.
Topics: Ascomycota; Drug Resistance, Fungal; Electrophoresis, Polyacrylamide Gel; Ergosterol; Fungicides, Industrial; Lanosterol; Plant Diseases; Protein Binding; Sterol 14-Demethylase; Triazoles | 2011 |
SREBP-dependent triazole susceptibility in Aspergillus fumigatus is mediated through direct transcriptional regulation of erg11A (cyp51A).
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Ergosterol; Fluconazole; Fungal Proteins; Gene Expression Regulation, Fungal; Genetic Complementation Test; Genotype; Humans; Microbial Sensitivity Tests; Organisms, Genetically Modified; Pyrimidines; Real-Time Polymerase Chain Reaction; Sterol Regulatory Element Binding Proteins; Transcription, Genetic; Triazoles; Voriconazole | 2012 |
Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus.
Topics: Amphotericin B; Animals; Aspergillus fumigatus; Biomass; Biosynthetic Pathways; Enoyl-CoA Hydratase; Ergosterol; Ferric Compounds; Gene Deletion; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Gene Silencing; Genes, Fungal; Hydroxamic Acids; Hydroxymethylglutaryl CoA Reductases; Iron Deficiencies; Ligases; Lovastatin; Mevalonic Acid; Mice; Microbial Sensitivity Tests; Oxidative Stress; Pulmonary Aspergillosis; Pyrimidines; Siderophores; Triazoles; Up-Regulation; Virulence; Voriconazole | 2012 |
SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus.
Topics: Animals; Antifungal Agents; Aspergillus fumigatus; Drug Resistance, Fungal; Ergosterol; Gene Expression Regulation, Fungal; Homeostasis; Humans; Iron; Lung Diseases, Fungal; Mice; Oligonucleotide Array Sequence Analysis; Siderophores; Sterol Regulatory Element Binding Proteins; Triazoles | 2011 |
How does antifungal pharmacology differ for mucormycosis versus aspergillosis?
Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus; Cell Membrane; Cell Wall; Drug Resistance, Multiple, Fungal; Ergosterol; Gene Duplication; Genome, Fungal; Genomic Instability; Humans; Itraconazole; Microbial Sensitivity Tests; Mucormycosis; Pyrimidines; Rhizopus; Species Specificity; Triazoles; Virulence Factors; Voriconazole | 2012 |
Facultative sterol uptake in an ergosterol-deficient clinical isolate of Candida glabrata harboring a missense mutation in ERG11 and exhibiting cross-resistance to azoles and amphotericin B.
Topics: Amphotericin B; Antifungal Agents; Azoles; Base Sequence; Biological Transport; Candida glabrata; Drug Resistance, Multiple, Fungal; Ergosterol; Fluconazole; Fungal Proteins; Humans; Microbial Sensitivity Tests; Mutation, Missense; Pyrimidines; Saccharomyces cerevisiae; Sequence Analysis, DNA; Sterol 14-Demethylase; Sterols; Triazoles; Voriconazole | 2012 |
Synergistic antifungal activity of statin-azole associations as witnessed by Saccharomyces cerevisiae- and Candida utilis-bioassays and ergosterol quantification.
Topics: Antifungal Agents; Candida; Disk Diffusion Antimicrobial Tests; Drug Resistance, Fungal; Drug Synergism; Ergosterol; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Microbial Sensitivity Tests; Saccharomyces cerevisiae; Species Specificity; Triazoles | 2013 |
Mechanism of action of efinaconazole, a novel triazole antifungal agent.
Topics: 14-alpha Demethylase Inhibitors; Antifungal Agents; Candida albicans; Dose-Response Relationship, Drug; Ergosterol; Hyphae; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Sterols; Triazoles; Trichophyton | 2013 |
Posaconazole exhibits in vitro and in vivo synergistic antifungal activity with caspofungin or FK506 against Candida albicans.
Topics: Animals; Antifungal Agents; Base Sequence; Candida albicans; Candidiasis; Caspofungin; Drug Resistance, Fungal; Drug Synergism; Echinocandins; Ergosterol; Lipopeptides; Male; Mice; Molecular Sequence Data; Mutation; Sequence Homology, Nucleic Acid; Tacrolimus; Triazoles | 2013 |
Molecular mechanisms of drug resistance in clinical Candida species isolated from Tunisian hospitals.
Topics: Amino Acid Sequence; Amino Acid Substitution; Amphotericin B; Antifungal Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azoles; Base Sequence; Candida albicans; Candida glabrata; Candida tropicalis; Candidiasis; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Ergosterol; Fluconazole; Fungal Proteins; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Mutation; Polyenes; Pyrimidines; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Analysis, DNA; Triazoles; Tunisia; Voriconazole | 2013 |
Functional characterization of FgERG3 and FgERG5 associated with ergosterol biosynthesis, vegetative differentiation and virulence of Fusarium graminearum.
Topics: Ergosterol; Fungal Proteins; Fungicides, Industrial; Fusarium; Gene Deletion; Genes, Fungal; Hyphae; Mutation; Oxidative Stress; Paraquat; Spores, Fungal; Triazoles; Triticum; Virulence | 2014 |
Efinaconazole (Jublia) for the treatment of onychomycosis.
Topics: 14-alpha Demethylase Inhibitors; Administration, Topical; Clinical Trials as Topic; Ergosterol; Humans; Microbial Sensitivity Tests; Onychomycosis; Triazoles | 2014 |
Design, synthesis and evaluation of benzotriazole derivatives as novel antifungal agents.
Topics: 14-alpha Demethylase Inhibitors; Antifungal Agents; Candida albicans; Chemistry Techniques, Synthetic; Drug Design; Drug Evaluation, Preclinical; Ergosterol; Fungal Proteins; Microbial Sensitivity Tests; Molecular Docking Simulation; Spectrophotometry, Ultraviolet; Sterol 14-Demethylase; Structure-Activity Relationship; Tandem Mass Spectrometry; Triazoles | 2015 |
Synthesis and antimicrobial potential of nitrofuran-triazole congeners.
Topics: Anti-Bacterial Agents; Antifungal Agents; Candida; Cell Line; Dose-Response Relationship, Drug; Ergosterol; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Nitrofurans; Structure-Activity Relationship; Triazoles | 2015 |
Potent In Vitro Antiproliferative Synergism of Combinations of Ergosterol Biosynthesis Inhibitors against Leishmania amazonensis.
Topics: 14-alpha Demethylase Inhibitors; Animals; Culture Media; Drug Synergism; Drug Therapy, Combination; Ergosterol; Farnesyl-Diphosphate Farnesyltransferase; Humans; Itraconazole; Leishmania mexicana; Leishmaniasis, Diffuse Cutaneous; Lipid Droplets; Membrane Potential, Mitochondrial; Mice; Mitochondria; Parasitic Sensitivity Tests; Pyridines; Quinuclidines; Reactive Oxygen Species; Sterol 14-Demethylase; Triazoles; Trypanocidal Agents | 2015 |
Cross-resistance to fluconazole induced by exposure to the agricultural azole tetraconazole: an environmental resistance school?
Topics: Animals; Anti-Allergic Agents; Antifungal Agents; ATP-Binding Cassette Transporters; Candida; Chlorobenzenes; Drug Resistance, Microbial; Ergosterol; Fluconazole; Fungicides, Industrial; Gene Expression Regulation, Fungal; Humans; Itraconazole; Malathion; Microbial Sensitivity Tests; Promethazine; Rhodamines; Sterol 14-Demethylase; Triazoles; Voriconazole | 2016 |
RNA-sequencing of Cercospora beticola DMI-sensitive and -resistant isolates after treatment with tetraconazole identifies common and contrasting pathway induction.
Topics: 14-alpha Demethylase Inhibitors; Ascomycota; Base Sequence; Chlorobenzenes; Drug Resistance, Fungal; Ergosterol; Fungicides, Industrial; High-Throughput Nucleotide Sequencing; Mutation; Sterol 14-Demethylase; Triazoles | 2016 |
Trypanosoma brucei CYP51: Essentiality and Targeting Therapy in an Experimental Model.
Topics: 14-alpha Demethylase Inhibitors; Animals; Anti-Bacterial Agents; Cytokinesis; Disease Models, Animal; Doxycycline; Eflornithine; Ergosterol; Humans; Mice; Nifurtimox; Phenotype; RNA Interference; Sterol 14-Demethylase; Triazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2016 |
Changes in In Vitro Susceptibility Patterns of Aspergillus to Triazoles and Correlation With Aspergillosis Outcome in a Tertiary Care Cancer Center, 1999-2015.
Topics: Adult; Antifungal Agents; Aspergillosis; Aspergillus; Aspergillus fumigatus; Cohort Studies; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Ergosterol; Female; Fungal Proteins; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Invasive Pulmonary Aspergillosis; Male; Microbial Sensitivity Tests; Polymorphism, Genetic; Prospective Studies; Tertiary Healthcare; Treatment Outcome; Triazoles; Voriconazole; Young Adult | 2017 |
Azole sensitivity in Leptosphaeria pathogens of oilseed rape: the role of lanosterol 14α-demethylase.
Topics: Ascomycota; Azoles; Binding Sites; Brassica; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Ergosterol; Fungicides, Industrial; Gene Expression Regulation, Fungal; Silanes; Sterol 14-Demethylase; Triazoles | 2017 |
Sterol Composition of Clinically Relevant Mucorales and Changes Resulting from Posaconazole Treatment.
Topics: Antifungal Agents; Aspergillus fumigatus; Drug Resistance, Fungal; Ergosterol; Gas Chromatography-Mass Spectrometry; Metabolomics; Molecular Structure; Mucorales; Species Specificity; Sterols; Triazoles | 2018 |
Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas' disease drug discovery.
Topics: Biological Assay; Chagas Disease; Drug Discovery; Ergosterol; Humans; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Heterologous Expression of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provides Tools for Antifungal Discovery.
Topics: Amphotericin B; Antifungal Agents; Azoles; Candida albicans; Candida glabrata; Drug Resistance, Fungal; Ergosterol; Fluconazole; Fungal Proteins; Humans; Itraconazole; Lanosterol; Microbial Sensitivity Tests; Saccharomyces cerevisiae; Sterol 14-Demethylase; Triazoles; Voriconazole | 2018 |
Gene transcription profiling of Aspergillus oryzae 3.042 treated with ergosterol biosynthesis inhibitors.
Topics: Aspergillus oryzae; Ergosterol; Fungal Proteins; Fungicides, Industrial; Gene Expression Profiling; Gene Expression Regulation, Fungal; Terbinafine; Transcription, Genetic; Triazoles | 2019 |
Characterization of propiconazole field-resistant isolates of Ustilaginoidea virens.
Topics: Drug Resistance, Fungal; Ergosterol; Fungal Proteins; Fungicides, Industrial; Hypocreales; Oryza; Plant Diseases; Sterol 14-Demethylase; Triazoles | 2019 |
Tetraconazole alters the methionine and ergosterol biosynthesis pathways in Saccharomyces yeasts promoting changes on volatile derived compounds.
Topics: Chlorobenzenes; Ergosterol; Fungicides, Industrial; Methionine; Saccharomyces; Triazoles; Volatile Organic Compounds | 2020 |
The Fungicide Tebuconazole Confounds Concentrations of Molecular Biomarkers Estimating Fungal Biomass.
Topics: Biomarkers; Biomass; Ergosterol; Fungi; Fungicides, Industrial; Triazoles | 2020 |
Isavuconazole nonwildtype Aspergillus fumigatus isolates from a global surveillance study display alterations in multiple genes involved in the ergosterol biosynthesis pathway not previously associated with resistance to other azoles.
Topics: Antifungal Agents; Aspergillus fumigatus; Azoles; Drug Resistance, Fungal; Ergosterol; Fungal Proteins; Humans; Itraconazole; Microbial Sensitivity Tests; Nitriles; Pyridines; Triazoles; Voriconazole; Whole Genome Sequencing | 2021 |
Novel (Z)/(E)-1,2,4-triazole derivatives containing oxime ether moiety as potential ergosterol biosynthesis inhibitors: design, preparation, antifungal evaluation, and molecular docking.
Topics: Antifungal Agents; Ergosterol; Ether; Ethers; Ethyl Ethers; Molecular Docking Simulation; Oximes; Structure-Activity Relationship; Triazoles | 2023 |
Antagonism of the Azoles to Olorofim and Cross-Resistance Are Governed by Linked Transcriptional Networks in Aspergillus fumigatus.
Topics: Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Azoles; Drug Resistance, Fungal; Ergosterol; Fungal Proteins; Gene Regulatory Networks; Humans; Microbial Sensitivity Tests; Pyrimidines; Transcription Factors; Triazoles | 2022 |