Compounds > triazoles
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triazoles and sm 164

triazoles has been researched along with sm 164 in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (5.26)29.6817
2010's13 (68.42)24.3611
2020's5 (26.32)2.80

Authors

AuthorsStudies
Bai, L; Lu, J; McEachern, D; Meagher, JL; Miller, RS; Nikolovska-Coleska, Z; Qiu, S; Shangary, S; Stuckey, JA; Sun, H; Sun, Y; Wang, S; Yi, H1
Bai, L; Davis, MA; Lawrence, TS; Li, H; Li, W; McEachern, D; Morgan, MA; Sebolt, JT; Sun, H; Sun, Y; Wang, S; Yang, J1
Bai, L; Bellail, A; Hao, C; Liao, J; Liu, M; Lu, J; McEachern, D; Miller, R; Peng, Y; Qiu, S; Sun, H; Sun, SY; Ting, AT; Wang, S; Yi, H1
Li, AY; Sun, Y; Wang, G; Wang, S; Yang, D; Zhao, Y1
Bai, L; Lu, J; McEachern, D; Sun, H; Wang, S; Yang, CY1
Cheung, HH; Korneluk, RG; Krishnan, L; McComb, S; Sad, S; Wang, S1
Chen, G; You, L; Zhang, J; Zhang, TP; Zhao, YP; Zhou, B1
Li, D; Li, G; Liu, G; Lu, J; Ma, X; Wang, Y; Wu, Y; Zhang, S; Zhao, Y1
Bei, JX; Chen, LZ; Feng, QS; Liang, Y; Min, P; Wang, GF; Wang, HB; Wu, MS; Wu, MY; Yang, D; Zeng, YX; Zhao, ZQ1
Delia, D; El-Attar, R; Kulms, D; Lecis, D; Odell, E; Papenfuss, K; Raulf, N; Tavassoli, M; Walczak, H1
Duckett, CS; Kocab, AJ; Ljungman, M; Paulsen, MT; Veloso, A1
Campo, E; Ceribelli, M; Chan, WC; Delabie, J; Gascoyne, RD; Huang, DW; Jaffe, ES; Kelly, P; Liu, X; Nakagawa, M; Ott, G; Rimsza, L; Rosenwald, A; Schmitz, R; Shaffer, AL; Staudt, LM; Webster, D; Wright, GW; Xu, W; Yang, Y; Yoo, HM; Young, RM; Yu, X; Zhao, H1
Gupte, A; Hawkins, CJ; Miles, MA; Shekhar, TM; Tascone, B; Taylor, S; Walkley, CR1
Chen, J; Chen, X; Sun, H; Yang, D1
Akara-Amornthum, P; Choksi, S; Jitkaew, S; Lomphithak, T; Tohtong, R1
Boyce, BF; Duan, R; Huston, A; Lei, W; Li, J; Liu, X; Yao, Z1
Baxter, AA; Caruso, S; Hawkins, CJ; Miles, MA; Poon, IKH1
Jin, HL; Jin, X; Li, MY; Ma, J; Ri, MH; Wang, JY; Xing, Y; Zhang, ZH; Zhong, Y; Zuo, HX1
Kuo, YC; Lee, YJ; Rajesh, R1

Other Studies

19 other study(ies) available for triazoles and sm 164

ArticleYear
SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP.
    Cancer research, 2008, Nov-15, Volume: 68, Issue:22

    Topics: Animals; Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Caspase 3; Caspase 8; Cell Line, Tumor; Humans; Inhibitor of Apoptosis Proteins; Mice; Mice, SCID; Triazoles; Tumor Necrosis Factor-alpha; X-Linked Inhibitor of Apoptosis Protein

2008
Radiosensitization of head and neck squamous cell carcinoma by a SMAC-mimetic compound, SM-164, requires activation of caspases.
    Molecular cancer therapeutics, 2011, Volume: 10, Issue:4

    Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Baculoviral IAP Repeat-Containing 3 Protein; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Squamous Cell; Caspase Inhibitors; Caspases; Cell Line, Tumor; Combined Modality Therapy; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Enzyme Activation; Flow Cytometry; Head and Neck Neoplasms; Humans; Inhibitor of Apoptosis Proteins; Mice; Mice, Nude; Molecular Structure; Proto-Oncogene Proteins c-bcl-2; Radiation-Sensitizing Agents; Radiotherapy; RNA Interference; Triazoles; Ubiquitin-Protein Ligases; Xenograft Model Antitumor Assays

2011
Therapeutic potential and molecular mechanism of a novel, potent, nonpeptide, Smac mimetic SM-164 in combination with TRAIL for cancer treatment.
    Molecular cancer therapeutics, 2011, Volume: 10, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Caspase 8; Cell Line, Tumor; Cell Survival; Death Domain Receptor Signaling Adaptor Proteins; Drug Synergism; Humans; Inhibitor of Apoptosis Proteins; Neoplasms; Nuclear Pore Complex Proteins; Protein Binding; RNA-Binding Proteins; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Triazoles; X-Linked Inhibitor of Apoptosis Protein

2011
Smac-mimetic compound SM-164 induces radiosensitization in breast cancer cells through activation of caspases and induction of apoptosis.
    Breast cancer research and treatment, 2012, Volume: 133, Issue:1

    Topics: Apoptosis; Breast Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enzyme Activation; Enzyme Activators; Female; Gene Knockdown Techniques; Humans; Inhibitor of Apoptosis Proteins; Oligopeptides; Protein Binding; Radiation-Sensitizing Agents; RNA Interference; Triazoles

2012
LRIG1 modulates cancer cell sensitivity to Smac mimetics by regulating TNFα expression and receptor tyrosine kinase signaling.
    Cancer research, 2012, Mar-01, Volume: 72, Issue:5

    Topics: Animals; Apoptosis Regulatory Proteins; Breast Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Down-Regulation; Drug Resistance, Neoplasm; Female; Humans; Intracellular Signaling Peptides and Proteins; Membrane Glycoproteins; Mice; Mice, SCID; Mitochondrial Proteins; Ovarian Neoplasms; Receptor Protein-Tyrosine Kinases; Signal Transduction; Triazoles; Tumor Necrosis Factor-alpha; Xenograft Model Antitumor Assays

2012
cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation.
    Cell death and differentiation, 2012, Volume: 19, Issue:11

    Topics: Animals; Apoptosis; Baculoviral IAP Repeat-Containing 3 Protein; Biomimetic Materials; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; GTPase-Activating Proteins; Inhibitor of Apoptosis Proteins; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Necrosis; Receptor-Interacting Protein Serine-Threonine Kinases; Receptors, Tumor Necrosis Factor; RNA Interference; RNA, Small Interfering; Triazoles; Ubiquitin-Protein Ligases; X-Linked Inhibitor of Apoptosis Protein

2012
Therapy of Smac mimetic SM-164 in combination with gemcitabine for pancreatic cancer.
    Cancer letters, 2013, Feb-01, Volume: 329, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Caspase 3; Cell Line, Tumor; Deoxycytidine; Gemcitabine; Humans; Mice; Mice, Nude; Pancreatic Neoplasms; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Triazoles; Xenograft Model Antitumor Assays

2013
Smac mimetic SM-164 potentiates APO2L/TRAIL- and doxorubicin-mediated anticancer activity in human hepatocellular carcinoma cells.
    PloS one, 2012, Volume: 7, Issue:12

    Topics: Antineoplastic Agents; APOBEC Deaminases; Apoptosis; Apoptosis Regulatory Proteins; Biomimetics; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Cytidine Deaminase; Doxorubicin; Humans; Intracellular Signaling Peptides and Proteins; Liver Neoplasms; Mitochondrial Proteins; Muscle Proteins; TNF-Related Apoptosis-Inducing Ligand; Triazoles

2012
Smac mimetics in combination with TRAIL selectively target cancer stem cells in nasopharyngeal carcinoma.
    Molecular cancer therapeutics, 2013, Volume: 12, Issue:9

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Azocines; Baculoviral IAP Repeat-Containing 3 Protein; Benzhydryl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Female; Humans; Inhibitor of Apoptosis Proteins; Intracellular Signaling Peptides and Proteins; Mice, Nude; Mitochondrial Proteins; Molecular Mimicry; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplastic Stem Cells; TNF-Related Apoptosis-Inducing Ligand; Triazoles; Ubiquitin-Protein Ligases; X-Linked Inhibitor of Apoptosis Protein; Xenograft Model Antitumor Assays

2013
Differential response of head and neck cancer cell lines to TRAIL or Smac mimetics is associated with the cellular levels and activity of caspase-8 and caspase-10.
    British journal of cancer, 2014, Nov-11, Volume: 111, Issue:10

    Topics: Apoptosis; BH3 Interacting Domain Death Agonist Protein; Biomimetics; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Squamous Cell; Caspase 10; Caspase 8; Cell Proliferation; Enzyme-Linked Immunosorbent Assay; Head and Neck Neoplasms; Humans; TNF-Related Apoptosis-Inducing Ligand; Triazoles; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2014
Effects of physiological and synthetic IAP antagonism on c-IAP-dependent signaling.
    Oncogene, 2015, Volume: 34, Issue:43

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cell Line, Tumor; CHO Cells; Cricetulus; Humans; Inhibitor of Apoptosis Proteins; Ki-1 Antigen; NF-kappa B; Signal Transduction; Transcription, Genetic; Transcriptome; Triazoles

2015
Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma.
    Cancer cell, 2016, Apr-11, Volume: 29, Issue:4

    Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis Regulatory Proteins; B-Cell CLL-Lymphoma 10 Protein; B-Lymphocytes; Baculoviral IAP Repeat-Containing 3 Protein; Bridged Bicyclo Compounds, Heterocyclic; CARD Signaling Adaptor Proteins; Caspases; Cell Line, Tumor; CRISPR-Cas Systems; Dipeptides; Enzyme Activation; Gene Dosage; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Guanylate Cyclase; Humans; I-kappa B Kinase; Indoles; Inhibitor of Apoptosis Proteins; Intracellular Signaling Peptides and Proteins; Lymphoma, Large B-Cell, Diffuse; Mice; Mice, Inbred NOD; Mice, SCID; Mitochondrial Proteins; Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein; Multiprotein Complexes; Neoplasm Proteins; NF-kappa B; Protein Processing, Post-Translational; Receptors, Antigen, B-Cell; Triazoles; Ubiquitin-Protein Ligases; Ubiquitination; Xenograft Model Antitumor Assays

2016
IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα.
    Oncotarget, 2016, Jun-07, Volume: 7, Issue:23

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Baculoviral IAP Repeat-Containing 3 Protein; Bone Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cell Survival; Cyclohexanes; Dose-Response Relationship, Drug; Genetic Predisposition to Disease; HEK293 Cells; Humans; Inhibitor of Apoptosis Proteins; Mice, Knockout; Osteosarcoma; Phenotype; Pyrroles; Receptor-Interacting Protein Serine-Threonine Kinases; Retinoblastoma Protein; Signal Transduction; Thiazoles; TNF-Related Apoptosis-Inducing Ligand; Transfection; Triazoles; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases

2016
SM‑164 enhances the antitumor activity of adriamycin in human U2‑OS cells via downregulation of X‑linked inhibitor of apoptosis protein.
    Molecular medicine reports, 2019, Volume: 19, Issue:6

    Topics: Antibiotics, Antineoplastic; Apoptosis; Bone Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Caspase 3; Cell Line, Tumor; Cell Survival; Down-Regulation; Doxorubicin; Drug Synergism; Humans; Inhibitor of Apoptosis Proteins; Osteosarcoma; Poly(ADP-ribose) Polymerases; RNA Interference; RNA, Small Interfering; Survivin; Triazoles; X-Linked Inhibitor of Apoptosis Protein

2019
Key necroptotic proteins are required for Smac mimetic-mediated sensitization of cholangiocarcinoma cells to TNF-α and chemotherapeutic gemcitabine-induced necroptosis.
    PloS one, 2020, Volume: 15, Issue:1

    Topics: Biliary Tract Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Caspase Inhibitors; Cell Cycle Checkpoints; Cell Line, Tumor; Cholangiocarcinoma; Deoxycytidine; Drug Synergism; Gemcitabine; Humans; Necroptosis; Protein Kinases; Receptor-Interacting Protein Serine-Threonine Kinases; RNA Interference; RNA, Small Interfering; Triazoles; Tumor Necrosis Factor-alpha

2020
The IAP Antagonist SM-164 Eliminates Triple-Negative Breast Cancer Metastasis to Bone and Lung in Mice.
    Scientific reports, 2020, 04-24, Volume: 10, Issue:1

    Topics: Animals; Apoptosis; Bone Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Doxorubicin; Female; Humans; Inhibitor of Apoptosis Proteins; Lung Neoplasms; Mice; Mice, Nude; RANK Ligand; Triazoles; Triple Negative Breast Neoplasms

2020
Smac mimetics can provoke lytic cell death that is neither apoptotic nor necroptotic.
    Apoptosis : an international journal on programmed cell death, 2020, Volume: 25, Issue:7-8

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Azocines; Benzhydryl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Caspase 3; Caspase 7; Cell Line, Tumor; Cyclohexylamines; Dipeptides; Ferroptosis; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Indoles; Mitochondrial Proteins; Molecular Mimicry; Necroptosis; Oligopeptides; Phenylenediamines; Protein Kinases; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction; Triazoles; Tumor Necrosis Factor-alpha

2020
Zinc finger protein 91 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation.
    Toxicology letters, 2022, Mar-01, Volume: 356

    Topics: Amino Acid Chloromethyl Ketones; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cell Survival; Gene Expression Regulation; Humans; Mice; Protein Kinases; Reactive Oxygen Species; Receptor-Interacting Protein Serine-Threonine Kinases; Receptors, Tumor Necrosis Factor, Type I; Signal Transduction; Systemic Inflammatory Response Syndrome; Triazoles; Tumor Necrosis Factor-alpha; Ubiquitin-Protein Ligases

2022
Enhanced activity of AZD5582 and SM-164 in rabies virus glycoprotein-lactoferrin-liposomes to downregulate inhibitors of apoptosis proteins in glioblastoma.
    Biomaterials advances, 2022, Volume: 133

    Topics: Alkynes; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Glioblastoma; Humans; Lactoferrin; Liposomes; Oligopeptides; Rabies virus; Triazoles

2022