2-(2-hydroxy-4-methylphenyl)aminothiazole profile

2-(2-hydroxy-4-methylphenyl)aminothiazole is a chemical compound that is a derivative of thiazole. It is a white solid and has several interesting properties that make it relevant for research in various fields.

**Structure and Properties:**

* **Thiazole ring:** The molecule contains a thiazole ring, a heterocyclic ring system known for its biological activity and its ability to interact with various enzymes and proteins.
* **Hydroxy and methyl groups:** The presence of a hydroxyl group and a methyl group on the phenyl ring adds to the compound's potential for interaction with biological systems. These groups can participate in hydrogen bonding and other intermolecular interactions.

**Importance for Research:**

* **Pharmacological studies:** 2-(2-hydroxy-4-methylphenyl)aminothiazole has shown potential as a pharmacological agent, exhibiting various biological activities. It has been investigated for its anti-inflammatory, anti-cancer, and antimicrobial properties.
* **Synthesis of new drugs:** The compound can serve as a building block for synthesizing new drugs with improved therapeutic profiles. Its unique structure and chemical properties provide a foundation for developing novel pharmaceutical agents.
* **Materials science:** 2-(2-hydroxy-4-methylphenyl)aminothiazole can be used in the synthesis of polymers and other materials with interesting properties. Its ability to interact with other molecules can lead to the development of new functional materials.
* **Analytical chemistry:** The compound can be used as a reagent or marker in analytical chemistry due to its ability to react with specific substances and form detectable products.

**Specific Research Areas:**

* **Anti-inflammatory activity:** Studies have shown that 2-(2-hydroxy-4-methylphenyl)aminothiazole possesses anti-inflammatory activity, potentially by inhibiting the production of pro-inflammatory cytokines.
* **Anti-cancer activity:** Some research suggests that this compound exhibits cytotoxic effects against certain cancer cell lines. Its potential as a cancer therapeutic agent is being explored further.
* **Antimicrobial activity:** The compound has shown promising results in inhibiting the growth of various bacteria and fungi, making it a potential candidate for developing new antimicrobial agents.

**Overall, 2-(2-hydroxy-4-methylphenyl)aminothiazole is a valuable compound for research due to its unique structure and diverse biological activities. It holds potential for applications in various fields, including pharmaceuticals, materials science, and analytical chemistry.**

**It is important to note that further research is necessary to fully understand the compound's potential and safety profile.**

2-(2-hydroxy-4-methylphenyl)aminothiazole: structure given in first source; cpd is also a free radical scavenger [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	163834
CHEBI ID	34598
SCHEMBL ID	2746827
MeSH ID	M0172923

Synonym
icoduline hydrochloride
cbs-113 a
cbs 113a
110952-54-0
phenol, 5-methyl-2-(2-thiazolylamino)-, monohydrochloride
2-(2-hydroxy-4-methylphenyl)aminothiazole
unii-frm2ibi8xa
frm2ibi8xa ,
m-cresol, 6-(2-thiazolylamino)-, monohydrochloride
cbs-113a
6-(2-thiazolylamino)-m-cresol monohydrochloride
2-(2-hydroxy-4-methylphenyl)aminothiazole hydrochloride
niosh/gp3140000
GP31400000
phenol, 5-methyl-2-(2-thiazolylamino)-, hydrochloride
SCHEMBL2746827
CHEBI:34598
5-methyl-2-(thiazol-2-ylamino)phenol
5-methyl 2-(2-thiazolylamino)phenol hydrochloride
phenol, 5-methyl-2-(2-thiazolylamino)-, hydrochloride (1:1)
DTXSID30911913
5-methyl-2-[(1,3-thiazol-2-yl)amino]phenol--hydrogen chloride (1/1)
Q27116170
5-methyl-2-(1,3-thiazol-2-ylamino)phenol;hydrochloride

Class	Description
organic molecular entity	Any molecular entity that contains carbon.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (42.86)	18.7374
1990's	4 (57.14)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (14.29%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (85.71%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
flurbiprofen Flurbiprofen: An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.. flurbiprofen : A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.	1.97	1	0	fluorobiphenyl; monocarboxylic acid	antipyretic; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug
indomethacin Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.	2.66	3	0	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic
thiazoles [no description available]	4.75	7	1	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
evans blue Evans Blue: An azo dye used in blood volume and cardiac output measurement by the dye dilution method. It is very soluble, strongly bound to plasma albumin, and disappears very slowly.. Evans blue : An organic sodium salt that is the tetrasodium salt of 6,6'-{(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis[diazene-2,1-diyl]}bis(4-amino-5-hydroxynaphthalene-1,3-disulfonate). It is sometimes used as a counterstain, especially in fluorescent methods to suppress background autofluorescence.	1.97	1	0	organic sodium salt	fluorochrome; histological dye; sodium channel blocker; teratogenic agent
tetradecanoylphorbol acetate Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.	1.97	1	0	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator
pobilukast pobilukast: a leukotriene receptor antagonist; an antiasthmatic agent; structure in first source; RN refers to (R-(R,S)-isomer	1.97	1	0
triazoles Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.	1.97	1	0	1,2,3-triazole
1-hexadecyl-2-acetyl-glycero-3-phosphocholine Platelet Activating Factor: A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION.. 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine : A 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine betaine which has hexadecyl as the alkyl group. PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis.	1.97	1	0	2-acetyl-1-alkyl-sn-glycero-3-phosphocholine	antihypertensive agent; beta-adrenergic antagonist; bronchoconstrictor agent; hematologic agent; vasodilator agent
arachidonic acid icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.	1.97	1	0	icosa-5,8,11,14-tetraenoic acid; long-chain fatty acid; omega-6 fatty acid	Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; human metabolite; mouse metabolite
bn 50730 BN 50730: platelet activating factor antagonist; structure given in first source	1.97	1	0
leukotriene b4 Leukotriene B4: The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990). leukotriene B4 : A leukotriene composed of (6Z,8E,10E,14Z)-icosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. It is a lipid mediator of inflammation that is generated from arachidonic acid via the 5-lipoxygenase pathway.	1.97	1	0	dihydroxy monocarboxylic acid; hydroxy polyunsaturated fatty acid; leukotriene; long-chain fatty acid	human metabolite; mouse metabolite; plant metabolite; vasoconstrictor agent
phosphatidylcholines Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.	1.97	1	0	1,2-diacyl-sn-glycero-3-phosphocholine
allopurinol Allopurinol: A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.. allopurinol : A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring.	1.97	1	0	nucleobase analogue; organic heterobicyclic compound	antimetabolite; EC 1.17.3.2 (xanthine oxidase) inhibitor; gout suppressant; radical scavenger

Condition	Relationship Strength	Studies	Trials
Recrudescence [description not available]	3.36	1	1
Episcleritis [description not available]	3.36	1	1
Scleritis Refers to any inflammation of the sclera including episcleritis, a benign condition affecting only the episclera, which is generally short-lived and easily treated. Classic scleritis, on the other hand, affects deeper tissue and is characterized by higher rates of visual acuity loss and even mortality, particularly in necrotizing form. Its characteristic symptom is severe and general head pain. Scleritis has also been associated with systemic collagen disease. Etiology is unknown but is thought to involve a local immune response. Treatment is difficult and includes administration of anti-inflammatory and immunosuppressive agents such as corticosteroids. Inflammation of the sclera may also be secondary to inflammation of adjacent tissues, such as the conjunctiva.	3.36	1	1
Pink Eye [description not available]	2.38	2	0
Extravasation of Contrast Media [description not available]	1.97	1	0
Conjunctivitis INFLAMMATION of the CONJUNCTIVA.	2.38	2	0
Uveitis Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina). (Dorland, 27th ed)	2.38	2	0
Abnormalities, Autosome [description not available]	1.97	1	0
Allergic Reaction [description not available]	1.97	1	0
Pleurisy INFLAMMATION of PLEURA, the lining of the LUNG. When PARIETAL PLEURA is involved, there is pleuritic CHEST PAIN.	1.97	1	0
Hypersensitivity Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.	1.97	1	0
Keratitis Inflammation of the cornea.	1.97	1	0
Infection [description not available]	1.97	1	0
Furrow Keratitis [description not available]	1.97	1	0
Infections Invasion of the host organism by microorganisms or their toxins or by parasites that can cause pathological conditions or diseases.	1.97	1	0

2-(2-hydroxy-4-methylphenyl)aminothiazole

Description

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Synonyms (24)

Drug Classes (1)

Research

Studies (7)

Market Indicators

Research Demand Index: 12.31

Study Types