| Assay ID | Title | Year | Journal | Article |
|---|
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1648488 | Binding affinity to C-terminal 6-His-tagged human CYP17A1 expressed in Escherichia coli assessed as induction of type II binding spectral changes at 50 uM using 1 uM CYP17A1 by spectroscopy | 2020 | Journal of medicinal chemistry, 06-25, Volume: 63, Issue:12
| Multistep Binding of the Non-Steroidal Inhibitors Orteronel and Seviteronel to Human Cytochrome P450 17A1 and Relevance to Inhibition of Enzyme Activity. |
| AID1648489 | Binding affinity to C-terminal 6-His-tagged human CYP17A1 expressed in Escherichia coli assessed as induction of spectral changes by measuring rate constant of first reaction at 50 uM using 1 uM CYP17A1 by spectroscopy | 2020 | Journal of medicinal chemistry, 06-25, Volume: 63, Issue:12
| Multistep Binding of the Non-Steroidal Inhibitors Orteronel and Seviteronel to Human Cytochrome P450 17A1 and Relevance to Inhibition of Enzyme Activity. |
| AID1142266 | Inhibition of CYP17 in gonadally-intact hamster assessed as progesterone level in serum at 50 mg/kg, po after 2 hrs by LC/MS/MS analysis (Rvb = 1.02 +/- 0.05 ng/mL) | 2014 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 24, Issue:11
| Highly-selective 4-(1,2,3-triazole)-based P450c17a 17,20-lyase inhibitors. |
| AID1648490 | Binding affinity to C-terminal 6-His-tagged human CYP17A1 expressed in Escherichia coli assessed as induction of spectral changes by measuring rate constant of second reaction at 50 uM using 1 uM CYP17A1 by spectroscopy | 2020 | Journal of medicinal chemistry, 06-25, Volume: 63, Issue:12
| Multistep Binding of the Non-Steroidal Inhibitors Orteronel and Seviteronel to Human Cytochrome P450 17A1 and Relevance to Inhibition of Enzyme Activity. |
| AID1142265 | Inhibition of CYP17 in gonadally-intact hamster assessed as testosterone level in serum at 50 mg/kg, po after 2 hrs by LC/MS/MS analysis (Rvb = 1.98 +/- 0.057 ng/mL) | 2014 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 24, Issue:11
| Highly-selective 4-(1,2,3-triazole)-based P450c17a 17,20-lyase inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |