Compounds > fluxofenim
Page last updated: 2024-11-06

fluxofenim

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Fluxofenim is a novel, potent, and selective inhibitor of the enzyme monoamine oxidase A (MAO-A). It is being investigated as a potential treatment for depression and other neuropsychiatric disorders. Fluxofenim is a racemic mixture, with the S-enantiomer being the primary pharmacologically active form. Fluxofenim is orally bioavailable and exhibits a long half-life. It is thought to exert its therapeutic effects by increasing levels of neurotransmitters such as serotonin and norepinephrine in the brain. Preclinical studies have shown promising results, suggesting that fluxofenim may have antidepressant and anxiolytic properties. However, further research is needed to evaluate its safety and efficacy in humans. It is important to note that fluxofenim is not currently approved for any clinical use.'

fluxofenim: herbicide safener [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID91747
CHEMBL ID3185597
CHEBI ID81924
MeSH IDM0280755

Synonyms (16)

Synonym
concep iii
ethanone, 1-(4-chlorophenyl)-2,2,2-trifluoro-, o-(1,3-dioxolan-2-ylmethyl)oxime
fluxofenim
o-(1,3-dioxolan-2-yl-methyl)-2,2,2-trifluoro-4'-chloroacetophenone oxime
benzacetonitrile
cga 133205
fluxofenim [iso]
1-(4-chlorophenyl)-2,2,2-trifluoroethanone o-(1,3-dioxolan-2-ylmethyl)oxime
C18735
1nuo7162k6 ,
unii-1nuo7162k6
cga-133205
CHEBI:81924 ,
CHEMBL3185597
Q3074557
ukslknucvpzqcq-uhfffaoysa-n
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
organochlorine compoundAn organochlorine compound is a compound containing at least one carbon-chlorine bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's7 (87.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 32.61

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index32.61 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index5.14 (4.65)
Search Engine Demand Index39.34 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (32.61)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
dinitrochlorobenzene
Dinitrochlorobenzene: A skin irritant that may cause dermatitis of both primary and allergic types. Contact sensitization with DNCB has been used as a measure of cellular immunity. DNCB is also used as a reagent for the detection and determination of pyridine compounds.. 1-chloro-2,4-dinitrobenzene : A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.		2.4420C-nitro compound;
monochlorobenzenes		allergen;
epitope;
sensitiser
terbutylazine
terbutylazine : A diamino-1,3,5-triazine that is N-tert-butyl-N'-methyl-1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6.		2.4420chloro-1,3,5-triazine;
diamino-1,3,5-triazine		environmental contaminant;
herbicide;
xenobiotic
butachlor
butachlor : An aromatic amide that is 2-choro-N-(2,6-diethylphenyl)acetamide in which the amide nitrogen has been replaced by a butoxymethyl group.		2.4420aromatic amide;
organochlorine compound;
tertiary carboxamide		environmental contaminant;
herbicide;
xenobiotic
dichlormid
dichlormid: antidote for EPTC injury in corn; structure		2.0110tertiary carboxamide
paroxetine
Paroxetine: A serotonin uptake inhibitor that is effective in the treatment of depression.. paroxetine : A benzodioxole that consists of piperidine bearing 1,3-benzodioxol-5-yloxy)methyl and 4-fluorophenyl substituents at positions 3 and 4 respectively; the (3S,4R)-diastereomer. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo.		2.0110aromatic ether;
benzodioxoles;
organofluorine compound;
piperidines		antidepressant;
anxiolytic drug;
hepatotoxic agent;
P450 inhibitor;
serotonin uptake inhibitor
benoxacor
benoxacor: a herbicide safener that protects corn from injury by metachlor		2.9440benzoxazine
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		2.03101,2,3-triazole
fenclorim
fenclorim: an herbicide		2.7330organohalogen compound;
pyrimidines
indole-3-lactic acid
indole-3-lactic acid: RN given refers to cpd without isomeric designation. 3-(indol-3-yl)lactic acid : A hydroxy monocarboxylic acid that is lactic acid substituted by a 1H-indol-3-yl group at position 3. It is a metabolite of tryptophan.		2.0110hydroxy monocarboxylic acid;
indol-3-yl carboxylic acid		human metabolite
cloquintocet-mexyl
cloquintocet-mexyl: an herbicide safener. cloquintocet-mexyl : A racemate composed of equimolar amounts of (R)- and (S)-cloquintocet-mexyl. It is a colourless crystalline herbicide safener which protects small cereal crops against the toxicity of the herbicide clodinafop-propargyl. The World Health Organization have categorized it as a class III toxin.. heptan-2-yl [(5-chloroquinolin-8-yl)oxy]acetate : A member of the class of quinolines that is quinoline which is substituted by a chloro group at position 5 and by a 2-[(heptan-2-yl)oxy]-2-oxoethoxy group at position 8.		2.4420aromatic ether;
carboxylic ester;
organochlorine compound;
quinolines
2-chloro-n-(ethoxymethyl)-n-(2-methyl-6-(trifluoromethyl)phenyl)acetamide
2-chloro-N-(ethoxymethyl)-N-(2-methyl-6-(trifluoromethyl)phenyl)acetamide: structure given in first source		2.0310
fenchlorazole-ethyl
fenchlorazole-ethyl: an herbicide safener		2.0310dichlorobenzene
ConditionIndicatedRelationship StrengthStudiesTrials
Depression, Endogenous
[description not available]		02.0110
Depressive Disorder
An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.		02.0110
Nausea
An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.		02.0110