A primary headache disorder that is characterized by severe, strictly unilateral PAIN which is orbital, supraorbital, temporal or in any combination of these sites, lasting 15-180 min. occurring 1 to 8 times a day. The attacks are associated with one or more of the following, all of which are ipsilateral: conjunctival injection, lacrimation, nasal congestion, rhinorrhea, facial SWEATING, eyelid EDEMA, and miosis. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
| Excerpt | Reference |
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| "Cluster headache is characterized by severe unilateral periorbital pain." | ( Diamond, S, 1979) |
| "Cluster headache is a form of unilateral headache which, in the past, has been very resistant to treatment." | ( Ashenhurst, EM; Wyant, GM, 1979) |
| "Attacks of cluster headache are difficult to treat." | ( , 1991) |
| "Cluster headache is a syndrome of severe head and facial pain accompanied by autonomic abnormalities." | ( Marks, DR; Rapoport, AM, 1992) |
| "Cluster headaches are vascular headaches that predominantly affect males and occur frequently, with cyclic regularity." | ( Gabai, IJ; Spierings, EL, 1990) |
| "Cluster headache is an uncommon form of headache syndrome." | ( Joubert, J, 1988) |
| "59 patients with cluster headache are discussed." | ( Huvenaars, P; Wentges, RT, 1986) |
| "Cluster headaches are so unique, however, that the history alone should be adequate for diagnosis." | ( Green, MW, 1983) |
| "Attacks of cluster headache are often associated with symptoms of an autonomic nature." | ( Saunte, C, 1984) |
| "Cluster headache is a defined disorder which is often mistaken in spite of its characteristic picture." | ( Neu, I; Pfaffenrath, V; Prosiegel, M, 1982) |
| "Atypical cluster headaches are localized headaches that occur several times daily, usually without any headache-free periods." | ( Diamond, S; Medina, JL, 1981) |
| "The course of cluster headache is related to changes in serotonin and histamine levels." | ( Diamond, S; Fareed, J; Medina, JL, 1980) |
| "Cluster headache is a rare very severe disorder that is clinically well characterized with a relatively poorly understood pathophysiology." | ( Edvinsson, L; Goadsby, PJ, 1994) |
| "Cluster headache is a rare form of severe idiopathic headache characterized by unilateral short-lasting episodes of excruciating pain in association with autonomic disturbances." | ( Goadsby, PJ, 1994) |
| "Cluster headache is a rare, very severe disorder that is clinically well characterized with a relatively poorly understood pathophysiology." | ( Blaes, F; Fischer, C; Grauer, M; Hamann, GF; Hoffmann, KH; Strittmatter, M, 1996) |
| "Cluster headache is included with the shorter-lasting headaches to attempt a nosological analysis of these syndromes." | ( Goadsby, PJ; Lipton, RB, 1997) |
| "Cluster headache is a rare very severe disorder that is clinically well characterized with a relatively poorly understood pathophysiology." | ( Blaes, F; Fischer, C; Grauer, M; Hamann, G; Hoffmann, KH; Schimrigk, K; Strittmatter, M, 1997) |
| "Cluster headache is a rare but very typical disease." | ( Koudstaal, PJ; Ridderikhoff, J, 1997) |
| "Episodic cluster headache is a well-recognized entity usually starting in the second decade of life." | ( Kuhar, M; Neubauer, D; Ravnik, IM, 1997) |
| "Horton's syndrome (cluster headache) is always unilateral and is often associated with unilateral lacrimation and rhinorrhoea." | ( Köling, A, 1998) |
| "Patients with cluster headache are often treated with lithium." | ( Fujikawa, T; Horiguchi, J; Kagaya, A; Takebayashi, M; Yamawaki, S, 1999) |
| "Cluster headache is a rare, severe, clinically well-characterized disorder that occurs in both episodic and chronic forms." | ( Gadoth, N; Hering-Hanit, R, 2000) |
| "Cluster headache is a devastating disorder which needs intensive drug treatment in the cluster periods." | ( Flote, VG; Gilhus, NE, 2000) |
| "Cluster headache is a rare, clinically well-characterized disabling disorder that occurs in both episodic and chronic forms." | ( Gadoth, N; Hering-Hanit, R, 2001) |
| "Cluster headache is the most painful headache syndrome known." | ( Rozen, TD, 2001) |
| "Cluster headache is a stereotypic headache disorder marked by short-lasting bouts of severe unilateral head pain and associated autonomic symptoms." | ( Peres, MF; Rozen, TD, 2001) |
| "Cluster headache is the most severe headache syndrome known to humans." | ( Rozen, TD, 2002) |
| "Cluster headache is perhaps the most painful of the primary headache disorders." | ( Peres, MF; Rozen, TD; Silberstein, SD; Siow, HC; Stiles, MA; Young, WB, 2002) |
| "Cluster headache is a well-characterized, strictly unilateral headache with cranial autonomic features and can be classified as episodic or chronic." | ( McGeeney, BE, 2003) |
| "Cluster headache is a stereotyped form of primary headache that while common in terms of neurologic illnesses is much less common as a cause of disabling headache than migraine." | ( Bahra, A; Goadsby, PJ, 2004) |
| "Cluster headache is characterized by typical autonomic dysfunctions including facial and intracranial vascular disturbances." | ( Gottselig, R; Messlinger, K, 2004) |
| "Chronic cluster headache is one of the most disabling of all neurologic conditions." | ( Rozen, TD, 2004) |
| "Cluster headache is a primary headache syndrome that is under-diagnosed and in many instances under-treated." | ( Rozen, TD, 2005) |
| "Cluster headache is a strictly unilateral headache that occurs in association with cranial autonomic features." | ( Goadsby, PJ; Matharu, MS, 2004) |
| "Cluster headache is the third most frequent type of primary cephalgia only exceeded in frequency by tension-type headache and migraine." | ( Bewermeyer, H; Kuhn, J, 2006) |
| "Attack treatment in cluster headache is based on sumatriptan and oxygen." | ( Fabre, N, 2005) |
| "Cluster headache is marked by its circadian rhythmicity and the hypothalamus appears to have a significant influence over cluster pathogenesis." | ( Rozen, TD, 2005) |
| "Cluster headache is an uncommon yet distinctive neurovascular syndrome occurring in either episodic or chronic patterns." | ( Capobianco, DJ; Dodick, DW, 2006) |
| "Cluster headache is a form of primary headache in which attacks are rapid in onset with very severe pain." | ( Bussone, G; Cittadini, E; Evers, S; Goadsby, PJ; May, A; Straube, A, 2006) |
| "Cluster headache is a form of primary headache that features repeated attacks of excruciatingly severe headache usually occurring several times a day." | ( Burns, B; Goadsby, PJ; Watkins, L, 2007) |
| "Cluster headache is characterized by severe, strictly unilateral pain attacks lasting 15 to 180 minutes localized to orbital, temporal, and midface areas accompanied by ipsilateral autonomic features." | ( Balasubramaniam, R; Klasser, GD, 2007) |
| "By far, Cluster headache is the most frequent of these syndromes." | ( Rosenberg-Nordmann, M; Sprenger, T; Tölle, TR, 2007) |
| "Cluster headache is a condition of extremely intense unilateral pain in the ocular or temporal region." | ( Nissilä, M, 2009) |
| "Cluster headache is remarkably responsive to treatment with oxygen, and yet our understanding of its mode of action is unknown." | ( Akerman, S; Goadsby, PJ; Holland, PR; Lasalandra, MP, 2009) |
| "Cluster headache is an extremely painful syndrome that occurs more frequently in men." | ( Budisić, M; Demarin, V; Lovrencić-Huzjan, A; Vuković, V, 2009) |
| "Cluster headache is a rare yet exquisitely painful primary headache disorder occurring in either episodic or chronic patterns." | ( Dodick, DW; Halker, R; Vargas, B, 2010) |
| "Cluster headache is an uncommon, but severely painful and disabling condition, with rapid onset." | ( Derry, S; Law, S; Moore, RA, 2010) |
| "Cluster headache is a rare primary headache disorder characterized by recurrent, stereotyped short-lasting attacks of severe, unilateral head pain accompanied by autonomic symptoms." | ( Grosberg, BM; Lipton, RB; Robbins, MS; Vollbracht, S, 2011) |
| "Episodic cluster headache is a severe headache syndrome and represents a suitable disease model for the investigation of episodic pain." | ( Boecker, H; Pfaffenrath, V; Rüther, KV; Seifert, CL; Sprenger, T; Tölle, TR; Valet, M, 2011) |
| "Cluster headache is characterized by severe attacks of unilateral pain, but many patients experience symptoms more commonly associated with migraine such as persistent pain." | ( Marmura, MJ; Pello, SJ; Young, WB, 2010) |
| "Cluster headache is a neurovascular disorder characterized by attacks of severe and strictly unilateral pain presenting in and around the orbit and temporal area." | ( Shoji, Y, 2011) |
| "Cluster headache is a rare primary neurovascular headache and a severe pain condition with unilateral headache over 15-180 minutes and concomitant unilateral autonomic symptoms." | ( Limmroth, V; Pageler, L, 2012) |
| "The prevalence of cluster headache is 0." | ( Jensen, RH; Tfelt-Hansen, PC, 2012) |
| "Cluster headache is associated with structural abnormalities of the hypothalamus." | ( Evers, S; Frese, A; Lepper, A; Nofer, JR; Summ, O, 2013) |
| "Because cluster headache is usually accompanied with teeth pain and/or neck pain, some patients aren't able to consult adequate medical institutions." | ( Owada, K, 2013) |
| "Cluster headache is an uncommon,severely painful, and disabling condition, with rapid onset." | ( Derry, S; Law, S; Moore, RA, 2013) |
| "The aetiology of cluster headache is partially unknown." | ( Donnet, A, 2015) |
| "Cluster headache is classified as a primary headache by definition not caused by an underlying pathology." | ( De Pue, A; Lutin, B; Paemeleire, K, 2016) |
| "Objective Episodic cluster headache is characterized by abnormalities in tyrosine metabolism (i." | ( Aguggia, M; Bolner, A; Bussone, G; D'Andrea, G; Fiore, PD; Giordano, G; Gucciardi, A; Leon, A; Leone, M; Perini, F; Saracco, MG, 2017) |
| "Cluster headache is a primary headache disorder that can occur in children and adolescents, and is a member of the broader diagnostic group of trigeminal autonomic cephalalgias." | ( Goadsby, P; Mack, KJ, 2016) |
| "Cluster headache is a rare cause of primary headache in children." | ( Alfaro-Iznaola, C; Ballesteros-Garcia, MM; Cuadrado-Martin, M; Natera-de Benito, D; Rodriguez-Diaz, R; Taboas-Pereira, MA, 2016) |
| "Cluster headache is characterized by severe, unilateral headache attacks of orbital, supraorbital or temporal pain lasting 15-180 min accompanied by ipsilateral lacrimation, rhinorrhea and other cranial autonomic manifestations." | ( Cecchini, AP; Giustiniani, A; Leone, M, 2017) |
| "Cluster headache is a debilitating disease characterized by excruciatingly painful attacks that affects 0." | ( Liebler, EJ; Mwamburi, M; Tenaglia, AT, 2017) |
| "Cluster headache is a trigeminal autonomic cephalalgia characterised by extremely painful, strictly unilateral, short-lasting headache attacks accompanied by ipsilateral autonomic symptoms or the sense of restlessness and agitation, or both." | ( Hoffmann, J; May, A, 2018) |
| "Cluster headache is a primary headache disorder characterized by multiple episodes of intense unilateral pain with autonomic features." | ( Robbins, MS; Wei, J, 2018) |
| "Cluster headache is a primary headache syndrome grouped under the trigeminal autonomic cephalalgias." | ( Rozen, TD, 2018) |
| "Both chronic and episodic cluster headaches are debilitating disorders which are often refractory to multiple prophylactic medication regimens." | ( Holland, LC; Limmer, AL; Loftus, BD, 2019) |
| "Cluster headaches are characterized by unilateral sudden onset of intense, brief, sharp pain along the side of the face around the eye." | ( Fadayomi, O; Kendall, MC; Nader, A, 2019) |
| "Cluster headache is not optimally treated and few clinical trials are available to model therapy, especially dosing and administration." | ( Clark, AS; Smith, TR; Wenzel, R, 2022) |
| "Episodic cluster headache is more responsive to acute therapy than chronic." | ( Barloese, M; Jensen, RH; Lund, N; Petersen, AS, 2021) |
| "Cluster headache is characterized by recurrent, unilateral attacks of excruciating pain associated with ipsilateral cranial autonomic symptoms." | ( Brudfors, M; Cheema, S; Danno, D; Grangeon, L; Matharu, M; Nachev, P; Tso, AR, 2021) |
| "Cluster headache is uncommon before 10 years of age and diagnosis is difficult in the first few years of life." | ( Barbosa, BLF; Bastos, SNMAN; Jevoux, C; Krymchantowski, A; Krymchantowski, AG; Silva, SF; Silva-Néto, RP, 2021) |
| "Cluster headache is a rare, strictly unilateral, severe episodic primary headache disorder." | ( Goadsby, PJ; O'Daly, O; Wei, DY; Zelaya, FO, 2022) |
| "As cluster headache is a rare condition and purely unilateral disorder, an analysis strategy to ensure all the image data corresponded to symptomatology in the same hemisphere, without losing coherence across the group, was adopted." | ( Goadsby, PJ; O'Daly, O; Wei, DY; Zelaya, FO, 2022) |
| "Cluster headache is a relatively rare, disabling primary headache disorder with a major impact on patients' quality of life." | ( Aleksovska, K; Carvalho, V; Evers, S; Goadsby, PJ; Jensen, RH; Leone, M; Manzoni, GC; May, A; Pascual, J; Pozo-Rosich, P; Romoli, M, 2023) |
| "The management of cluster headache is similar to that of other primary headache disorders and can be broadly divided into acute and preventive treatments." | ( Burish, MJ; Peng, KP, 2023) |
| "Cluster headache is treated with acute treatments, bridge treatments, and preventive treatments." | ( Burish, MJ; Peng, KP, 2023) |
| "Treatment for cluster headache is currently based on a trial-and-error approach." | ( Belin, AC; Fronczek, R; Gaul, C; Jensen, RH; Lund, NLT; Meisingset, T; Petersen, AS; Steinberg, A; Tfelt-Hansen, J; Tronvik, E, 2023) |
| Excerpt | Reference |
|---|
| "Fifteen patients with symptomatic cluster headache participated in a double-blind crossover trial of a combined histamine H1 and H2 antagonist treatment." | ( Russell, D, 1979) |
| "Eight patients with episodic cluster headache, five in active episode, three out of episode, were investigated as to diameters of intracranial arteries before and after nitroglycerin (NG) administration." | ( Greitz, D; Hannerz, J, 1992) |
| "Attacks of cluster headache are difficult to treat." | ( , 1991) |
| "We report a 31-year-old man with cluster headaches who developed severe, prolonged myocardial ischemia following combination therapy with ergotamine tartrate and methysergide." | ( Galer, BS; Lipton, RB; Newman, LC; Solomon, S; Spierings, EL, 1991) |
| "Medical treatment of chronic cluster headaches (cluster headaches that occur frequently without remission) can be very difficult." | ( Covington, EC; Hassenbusch, SJ; Kosmorsky, GS; Kunkel, RS; Pillay, PK, 1991) |
| "We reviewed our experience with 54 cluster headache patients (23 episodic, 31 chronic) admitted to our headache center 64 tines over the past five years and treated with repetitive intravenous dihydroergotamine (IV DHE)." | ( Hopkins, MM; Mather, PJ; Schulman, EA; Silberstein, SD, 1991) |
| "Attacks of cluster headache provoked by the administration of nitroglycerin (1 mg sublingually) or histamine (0." | ( Bogucki, A, 1990) |
| "Ten episodic cluster headache patients in their active cluster period, ten patients in remission and five control subjects were monitored for minute to minute changes in oxygen saturation (SaO2) and pulse rate before and after nitroglycerin (NTG) administration." | ( Kudrow, DB; Kudrow, L, 1990) |
| "Chronic Cluster Headache (CCH) treatment is troublesome; since there are no pain-free periods, it must be continuous." | ( Bussone, G; Granella, F; Leone, M; Magri, M; Manzoni, GC; Micieli, G; Nappi, G; Peccarisi, C, 1990) |
| "15 chronic cluster headache patients in whom pain was induced by nitroglycerin received acute intravenous treatment with a calcium entry blocker." | ( Boiardi, A; Bussone, G; Gemma, M; Peccarisi, C; Porta, E, 1986) |
| "Seven therapy-resistant patients with cluster headache (six of whom were chronic) were treated by percutaneous retro-Gasserian glycerol injections under general anesthesia." | ( Ekbom, K; Hardebo, JE; Lindgren, L; Nilsson, BY; Waldenlind, E, 1987) |
| "After treatment with cyproheptadine, the cluster headache attacks ceased, but 2 days later, before the discontinuation of the treatment, the attacks of trigeminal neuralgia reappeared." | ( Klimek, A, 1987) |
| "Our patient, who had been suffering from cluster headache for approximately 30 years, had been in haemodialysis treatment for the last ten years for chronic renal failure." | ( Corsini, GU; Del Zompo, M; Mulas, S; Zuddas, A, 1985) |
| "Twenty-one patients with cluster headaches participated in an open trial to assess the effectiveness of lithium carbonate in the acute treatment and prevention of cluster headaches." | ( Damasio, H; Lyon, L, 1980) |
| "6 patients with chronic cluster headache were treated with lithium carbonate in order to establish the individual lowest effective dose and to assess the possibility of suspending treatment after prolonged administration." | ( Manzoni, GC; Terzano, MG, 1980) |
| "The way interrupting the treatment in episodic cluster headache is proposed." | ( Manzoni, GC; Parma, M; Terzano, MG, 1980) |
| "Patients with cluster headache were treated for acute attacks with sumatriptan 6mg subcutaneously or placebo in 2 crossover trials." | ( McTavish, D; Plosker, GL, 1994) |
| "Thirty male patients with cluster headache were given 4% lidocaine solution to use intranasally as an abortive therapy." | ( Robbins, L, 1995) |
| "With verapamil cluster headache can be treated successfully, flunarizine shows less impressive clinical efficacy." | ( Wessely, P; Wöber-Bingöl, C, 1993) |
| "Eighteen cluster headache patients and five controls were studied using ultrasound duplex techniques to measure blood flow in the common carotid arteries after nitroglycerin and placebo administration." | ( Hannerz, J; Jogestrand, T, 1993) |
| "It has been suggested that treatment of cluster headache (CH) patients with topical capsaicin may desensitize sensory neurons by depleting the nerve terminals of substance P." | ( Arrowsmith, F; Marks, DR; Padla, D; Rapoport, A; Rosum, R; Sheftell, F; Weeks, R, 1993) |
| "In 75% of patients with cluster headache treated with sumatriptan 6 mg sc, relief was achieved within 15 min." | ( Diener, HC; Pfaffenrath, V; Schoenen, J; Steiner, TJ; Wilkinson, M, 1995) |
| "The spontaneous capricious course of cluster headache may give rise to some problems when treatment is being evaluated." | ( Ekbom, K, 1995) |
| "Five patients with cluster headache and 15 patients with migraine were treated." | ( Hauser, R; Probst, R; Welge-Lüssen, A, 1996) |
| "Nine patients with chronic cluster headache were studied as to end-tidal PCO2, heart rate, blood pressure, common carotid artery blood flow, vascular resistance, and intensity and duration of pain before, during, and after breathing 6% CO2 in air for 6 minutes and before and after administration of 1 mg nitroglycerin sublingually." | ( Hannerz, J; Jogestrand, T, 1996) |
| "All of the treated 14 chronic cluster headache patients completed the study." | ( Di Sabato, F; Giacovazzo, M; Martelletti, P; Rocco, M, 1997) |
| "Many cluster headache patients had not, to their knowledge, been prescribed or used the best symptomatic and prophylactic treatments for cluster headache." | ( Becker, WJ; Riess, CM; Robertson, M, 1998) |
| "Subcutaneous self-treatment of cluster headache is both highly effective and well tolerated." | ( Göbel, H; Heinze, A; Lindner, V; Pfaffenrath, V; Ribbat, M; Stolze, H, 1998) |
| "Patients with cluster headache are often treated with lithium." | ( Fujikawa, T; Horiguchi, J; Kagaya, A; Takebayashi, M; Yamawaki, S, 1999) |
| "The treatment of cluster headache patients is at present suboptimal, both regarding symptomatic and prophylactic drugs." | ( Flote, VG; Gilhus, NE, 2000) |
| "Four patients continued to treat all cluster headache attacks with the intranasal sumatriptan formula, two patients had switched to subcutaneous sumatriptan and one patient was in remission since the end of the study." | ( Arnold, G; Einhäupl, KM; Kinze, S; Reuter, U; Schuh-Hofer, S, 2002) |
| "A 36-year-old man with cluster headache refractory to trials of standard prophylactic treatment and only partially responsive to parenteral sumatriptan and inhaled oxygen was admitted to an inpatient pain unit." | ( Loder, E, 2002) |
| "The number of cluster headaches per week during the treatment and posttreatment periods, pain intensity, presence of associated symptoms, and the incidence of adverse events were assessed." | ( Bernstein, JE; Klapper, J; Mathew, NT; Phillips, SB; Rapoport, A; Saper, JR, 2002) |
| "We treated 14 cluster headache patients with greater occipital nerve block as transitional therapy (treatment initiated at the same time as preventive therapy)." | ( Peres, MF; Rozen, TD; Silberstein, SD; Siow, HC; Stiles, MA; Young, WB, 2002) |
| "Patients with chronic cluster headache completed a baseline diary for 1 month, followed by 1 month of melatonin treatment, then 1 month of placebo." | ( Aubé, M; Dobson, CF; Hamel, E; Magnoux, E; Pringsheim, T, 2002) |
| "Patients with chronic cluster headache or patients with episodic cluster headache whose headaches are uncontrolled on conventional therapy do not appear to gain therapeutically from the addition of melatonin to their usual treatment regimens." | ( Aubé, M; Dobson, CF; Hamel, E; Magnoux, E; Pringsheim, T, 2002) |
| "In episodic cluster headache early treatment onset stopped attacks within 20 days in 80%, late treatment onset was successful within ten days in 67%." | ( Stallmach, M, 2003) |
| "For the treatment of episodic cluster headache, there was complete resolution in 44 (73%) of 60 cases, partial resolution in 9 cases (13%), and failure in 7 cases (12%)." | ( Magnoux, E; Zlotnik, G, 2004) |
| "The number of cluster headache attacks was recorded during a baseline period of 6 days, and during 6 days of treatment with eletriptan 40 mg twice daily." | ( Vigl, M; Wessely, P; Wöber, C; Zebenholzer, K, 2004) |
| "The clinical management of cluster headache (CH) attacks requires a symptomatic treatment that is rapidly effective in resolving or significantly reducing symptoms." | ( Manzoni, GC; Torelli, P, 2004) |
| "This report describes four patients with cluster headache who developed gingival enlargement after initiating treatment with verapamil." | ( Ferrari, MD; Goadsby, PJ; Matharu, MS; van Vliet, JA, 2005) |
| "We report three cases with cluster headache treated with sumatriptan nasal spray." | ( Oda, A; Watanabe, M, 2005) |
| "Attack treatment in cluster headache is based on sumatriptan and oxygen." | ( Fabre, N, 2005) |
| "Chronic cluster headache remains refractory to medical therapy in at least 30% of those who suffer from this condition." | ( de Campos, RW; Kowacs, PA; Lange, MC; Piovesan, EJ; Werneck, LC; Zetola, VF, 2005) |
| "He was recently diagnosed with cluster headaches and was treated with indomethacin, prednisone, butalbital-acetaminophen-caffeine and hydrocodone without relief." | ( Fulton, JA; Hoffman, RS; Kahn, J; Nelson, LS, 2006) |
| "The authors interviewed 53 cluster headache patients who had used psilocybin or lysergic acid diethylamide (LSD) to treat their condition." | ( Halpern, JH; Pope, HG; Sewell, RA, 2006) |
| "For the acute treatment of cluster headache attacks, oxygen (100%) with a flow of at least 7 l/min over 15 min and 6 mg subcutaneous sumatriptan are drugs of first choice." | ( Afra, J; Evers, S; Goadsby, PJ; Leone, M; Linde, M; May, A; Sándor, PS, 2006) |
| "Patients with chronic cluster headache have unremitting illness that necessitates daily preventive medical treatment for years." | ( Burns, B; Goadsby, PJ; Watkins, L, 2007) |
| "Occipital nerve stimulation in cluster headache seems to offer a safe, effective treatment option that could begin a new era of neurostimulation therapy for primary headache syndromes." | ( Burns, B; Goadsby, PJ; Watkins, L, 2007) |
| "A treatment refractory chronic cluster headache patient is presented who became cluster-free on clomiphene citrate." | ( Rozen, T, 2008) |
| "A fraction of cluster headache (CH) patients face diagnostic delay, misdiagnosis, undertreatment and mismanagement." | ( Crevits, L; Louis, P; Paemeleire, K; Vakaet, A; Van Alboom, E; Van Zandijcke, M, 2009) |
| "Migraine and cluster headache (CH) are disabling syndromes that often require prophylactic treatment." | ( Lovell, BV; Marmura, MJ, 2010) |
| "Most cluster headache patients respond to oxygen therapy, but approximately 20% do not." | ( Backx, AP; De Ceuster, L; Haane, DY; Koehler, PJ, 2010) |
| "Rapid recurrence of a new cluster headache attack following oxygen treatment was named the 'rebound effect' by Kudrow (1981)." | ( Geerlings, RP; Haane, DY; Koehler, PJ, 2011) |
| "The number of cluster headache attacks (primary efficacy variable) during the three-week treatment period was reduced from 14." | ( Bøe, MG; Dahløf, C; Jansson, SO; Monstad, I; Salvesen, R; Stovner, LJ; Tjensvoll, AB; Tronvik, E; Wienecke, T; Zwart, JA, 2013) |
| "Eligible patients with episodic cluster headache will be randomized to a treatment intervention with prednisone or a placebo arm." | ( Burmeister, J; Diener, HC; Holle, D; Obermann, M; Ose, C; Scherag, A, 2013) |
| "For preventive treatment of cluster headache, calcium channel blocker (verapamil) and steroids are recommended." | ( Shimizu, T, 2013) |
| "Bipolar disorder (BD) and cluster headache (CH) are distinct conditions with important similarities such as a temporal pattern of disturbances, dysregulation of the sleep-wake cycle, and response to lithium treatment in a proportion of patients." | ( Alda, M; Angius, A; Ardau, R; Chillotti, C; Congiu, D; Costa, M; Deidda, A; Del Zompo, M; Niola, P; Persico, AM; Piras, IS; Pisanu, C; Severino, G; Squassina, A; Stochino, E, 2015) |
| "Conclusion Oxygen for the treatment of cluster headache attack is not reimbursed worldwide." | ( Evers, S; Rapoport, A, 2017) |
| "Background Treatment options for cluster headache (CH) include acute, transitional and prophylactic strategies." | ( Abbas, H; Diener, HC; Dresler, T; Gaul, C; Görlinger, K; Roguski, J; Totzeck, A; Weber, R, 2017) |
| "Patients with cluster headaches occasionally fail to respond to conventional preventive treatments." | ( Imai, N, 2016) |
| "Large international surveys of cluster headache are rare, as are examinations of treatments and side effects in older cluster headache patients." | ( Burish, MJ; Pearson, SM; Schor, LI; Shapiro, RE; Yan, Y, 2019) |
| "Refractory chronic cluster headache (CCH) is a rare but highly debilitating condition that needs new treatment options." | ( Ciampi de Andrade, D; Clavelou, P; Condé, S; Dallel, R; Giraud, P; Meunier, E; Moisset, X; Pereira, B; Périé, M; Picard, P, 2020) |
| "Pharmacological treatment of cluster headache constitutes the core of clinical management, but evidence is sparse." | ( Barloese, M; Jensen, RH; Lund, N; Petersen, AS, 2021) |
| "Episodic cluster headache is more responsive to acute therapy than chronic." | ( Barloese, M; Jensen, RH; Lund, N; Petersen, AS, 2021) |
| "Newer treatments for cluster headache include galcanezumab, neurostimulation, and somatostatin receptor agonists." | ( Bailey, J; Hawks, MK; Malu, OO, 2022) |
| "The response to cluster headache treatments has a high interindividual variation." | ( Barloese, M; Callesen, I; Chalmer, MA; Hansen, MB; Hansen, TF; Jensen, RH; Lund, N; Ostrowski, SR; Pedersen, AF; Pedersen, OB; Petersen, AS; Sellebjerg, F; Søborg, MK; Søndergaard, HB; Winsvold, BS; Zwart, JA, 2023) |
| "In, 508 cluster headache patients diagnosed according to the International Classification of Headache Disorders were genotyped and participated in a semi-structured interview to evaluate treatment response." | ( Barloese, M; Callesen, I; Chalmer, MA; Hansen, MB; Hansen, TF; Jensen, RH; Lund, N; Ostrowski, SR; Pedersen, AF; Pedersen, OB; Petersen, AS; Sellebjerg, F; Søborg, MK; Søndergaard, HB; Winsvold, BS; Zwart, JA, 2023) |
| "For the acute treatment of cluster headache attacks, there is a strong recommendation for oxygen (100%) with a flow of at least 12 L/min over 15 min and 6 mg subcutaneous sumatriptan." | ( Aleksovska, K; Carvalho, V; Evers, S; Goadsby, PJ; Jensen, RH; Leone, M; Manzoni, GC; May, A; Pascual, J; Pozo-Rosich, P; Romoli, M, 2023) |
| "The management of cluster headache is similar to that of other primary headache disorders and can be broadly divided into acute and preventive treatments." | ( Burish, MJ; Peng, KP, 2023) |
| "Treatment for cluster headache is currently based on a trial-and-error approach." | ( Belin, AC; Fronczek, R; Gaul, C; Jensen, RH; Lund, NLT; Meisingset, T; Petersen, AS; Steinberg, A; Tfelt-Hansen, J; Tronvik, E, 2023) |