Page last updated: 2024-12-05

phenylmethanesulfonic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Phenylmethanesulfonic acid, also known as benzenesulfonic acid, is an organic compound with the formula C6H5CH2SO3H. It is a colorless, crystalline solid that is soluble in water and other polar solvents. Phenylmethanesulfonic acid is a strong acid that is used as a catalyst in various chemical reactions, including the sulfonation of aromatic compounds. It is also used in the manufacture of dyes, pharmaceuticals, and other chemicals. The compound has a pKa of -2.57. It is a strong acid that is used in various applications including synthesis, pharmaceuticals, and as a catalyst for many reactions.'

phenylmethanesulfonic acid: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID7532
CHEMBL ID1171433
SCHEMBL ID1749
SCHEMBL ID10433744
MeSH IDM0109040

Synonyms (28)

Synonym
methanesulfonic acid, phenyl-
brn 2208420
hsdb 5339
einecs 202-897-6
phenylmethanesulfonic acid
DB03297
alpha-toluenesulfonic acid
toluene-alpha-sulphonic acid
benzenemethanesulfonic acid
benzylsulfonic acid
CHEMBL1171433
AKOS006279270
100-87-8
4-11-00-00485 (beilstein handbook reference)
5brp81v98h ,
unii-5brp81v98h
NIXKBAZVOQAHGC-UHFFFAOYSA-N
phenylmethanesulphonic acid
SCHEMBL1749
.alpha.-toluenesulfonic acid
toluene-.alpha.-sulphonic acid
benzyl-.alpha.-sulfonic acid
benzylsulfonic acid [hsdb]
DTXSID2059221
toluene-alpha-sulfonic acid
SCHEMBL10433744
Q27261795
STARBLD0018790

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" A virtual fragment screen was undertaken of the enzyme to discover starting points for the development of inhibitors which are likely to have appropriate physicochemical properties for an orally bioavailable compound."( Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase.
Alibu, VP; Barrett, MP; Brenk, R; Campbell, G; Gilbert, IH; Ruda, GF, 2010
)
0.36
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID492274Inhibition of Trypanosoma brucei 6PGDH expressed in Escherichia coli at 200 uM by spectroscopy2010Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (18.18)18.7374
1990's0 (0.00)18.2507
2000's5 (45.45)29.6817
2010's3 (27.27)24.3611
2020's1 (9.09)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 16.85

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index16.85 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.16 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (16.85)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]