cay 10580 profile

CAY 10580: a E-prostanoid EP4 receptor agonist [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid : A pyrrolidin-2-one substituted by 6-carboxyhexyl and 3-hydroxyoctyl groups at positions 1 and 2, respectively. It is a potent prostaglandin EP4 receptor agonist (Ki=35 nM). [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	44269516
CHEMBL ID	15096
CHEBI ID	194210
MeSH ID	M0562113

Synonym
7-[2-(3-hydroxy-octyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid
bdbm50125403
CHEMBL15096 ,
2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid
cay 10580
CHEBI:194210
64054-40-6
7-[2-(3-hydroxyoctyl)-5-oxopyrrolidin-1-yl]heptanoic acid
cay-10580
cay10580
DTXSID10658096
AKOS027288931
7-(2-(3-hydroxyoctyl)-5-oxopyrrolidin-1-yl)heptanoic acid
CS-0110313
HY-135259
mfcd11976917

Role	Description
prostaglandin receptor agonist	An agonist that binds to and activates prostaglandin receptors.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
pyrrolidin-2-ones	A pyrrolidinone in which the oxo group is at position 2 of the pyrrolidine ring.
hydroxy monocarboxylic acid	Any monocarboxylic acid which also contains a separate (alcoholic or phenolic) hydroxy substituent.
secondary alcohol	A secondary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (8)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Thromboxane A2 receptor	Homo sapiens (human)	Ki	13.0000	0.0006	1.2407	3.8040	AID161215
Prostaglandin E2 receptor EP1 subtype	Homo sapiens (human)	Ki	13.0000	0.0091	0.6635	1.5849	AID160687
Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)	Ki	0.0350	0.0001	0.4744	3.1623	AID161075
Prostaglandin F2-alpha receptor	Homo sapiens (human)	Ki	13.0000	0.0310	3.3803	9.9910	AID160705
Prostaglandin E2 receptor EP3 subtype	Homo sapiens (human)	Ki	2.0000	0.0003	1.7081	6.8000	AID160689
Prostaglandin E2 receptor EP2 subtype	Homo sapiens (human)	Ki	3.0000	0.0010	0.5448	3.0000	AID160688
Prostacyclin receptor	Homo sapiens (human)	Ki	13.0000	0.0032	0.4958	6.6280	AID160763
Prostaglandin D2 receptor	Homo sapiens (human)	Ki	13.0000	0.0006	0.4913	1.4000	AID160535
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (58)

Process	via Protein(s)	Taxonomy
smooth muscle contraction	Thromboxane A2 receptor	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Thromboxane A2 receptor	Homo sapiens (human)
response to nutrient	Thromboxane A2 receptor	Homo sapiens (human)
response to xenobiotic stimulus	Thromboxane A2 receptor	Homo sapiens (human)
positive regulation of blood coagulation	Thromboxane A2 receptor	Homo sapiens (human)
response to testosterone	Thromboxane A2 receptor	Homo sapiens (human)
thromboxane A2 signaling pathway	Thromboxane A2 receptor	Homo sapiens (human)
response to ethanol	Thromboxane A2 receptor	Homo sapiens (human)
positive regulation of angiogenesis	Thromboxane A2 receptor	Homo sapiens (human)
positive regulation of smooth muscle contraction	Thromboxane A2 receptor	Homo sapiens (human)
cellular response to lipopolysaccharide	Thromboxane A2 receptor	Homo sapiens (human)
negative regulation of cell migration involved in sprouting angiogenesis	Thromboxane A2 receptor	Homo sapiens (human)
inflammatory response	Thromboxane A2 receptor	Homo sapiens (human)
positive regulation of blood pressure	Thromboxane A2 receptor	Homo sapiens (human)
positive regulation of vasoconstriction	Thromboxane A2 receptor	Homo sapiens (human)
positive regulation of cytosolic calcium ion concentration	Thromboxane A2 receptor	Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathway	Thromboxane A2 receptor	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Prostaglandin E2 receptor EP1 subtype	Homo sapiens (human)
adenylate cyclase-activating dopamine receptor signaling pathway	Prostaglandin E2 receptor EP1 subtype	Homo sapiens (human)
response to lipopolysaccharide	Prostaglandin E2 receptor EP1 subtype	Homo sapiens (human)
positive regulation of cytosolic calcium ion concentration	Prostaglandin E2 receptor EP1 subtype	Homo sapiens (human)
inflammatory response	Prostaglandin E2 receptor EP1 subtype	Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathway	Prostaglandin E2 receptor EP1 subtype	Homo sapiens (human)
negative regulation of cytokine production	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
positive regulation of cytokine production	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
immune response	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
JNK cascade	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
response to mechanical stimulus	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
response to nematode	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
regulation of ossification	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
response to lipopolysaccharide	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
negative regulation of integrin activation	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
T-helper cell differentiation	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
negative regulation of inflammatory response	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
positive regulation of inflammatory response	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
regulation of stress fiber assembly	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
bone development	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
ERK1 and ERK2 cascade	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
cellular response to mechanical stimulus	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
negative regulation of eosinophil extravasation	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
cellular response to prostaglandin E stimulus	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathway	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
positive regulation of cytosolic calcium ion concentration	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
inflammatory response	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Prostaglandin F2-alpha receptor	Homo sapiens (human)
parturition	Prostaglandin F2-alpha receptor	Homo sapiens (human)
positive regulation of cell population proliferation	Prostaglandin F2-alpha receptor	Homo sapiens (human)
positive regulation of gene expression	Prostaglandin F2-alpha receptor	Homo sapiens (human)
response to estradiol	Prostaglandin F2-alpha receptor	Homo sapiens (human)
response to lipopolysaccharide	Prostaglandin F2-alpha receptor	Homo sapiens (human)
negative regulation of apoptotic process	Prostaglandin F2-alpha receptor	Homo sapiens (human)
cellular response to prostaglandin D stimulus	Prostaglandin F2-alpha receptor	Homo sapiens (human)
inflammatory response	Prostaglandin F2-alpha receptor	Homo sapiens (human)
positive regulation of cytosolic calcium ion concentration	Prostaglandin F2-alpha receptor	Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathway	Prostaglandin F2-alpha receptor	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Prostaglandin E2 receptor EP3 subtype	Homo sapiens (human)
cell death	Prostaglandin E2 receptor EP3 subtype	Homo sapiens (human)
positive regulation of fever generation	Prostaglandin E2 receptor EP3 subtype	Homo sapiens (human)
intestine smooth muscle contraction	Prostaglandin E2 receptor EP3 subtype	Homo sapiens (human)
phospholipase C-activating G protein-coupled receptor signaling pathway	Prostaglandin E2 receptor EP3 subtype	Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathway	Prostaglandin E2 receptor EP3 subtype	Homo sapiens (human)
inflammatory response	Prostaglandin E2 receptor EP3 subtype	Homo sapiens (human)
positive regulation of cytosolic calcium ion concentration	Prostaglandin E2 receptor EP3 subtype	Homo sapiens (human)
negative regulation of gastric acid secretion	Prostaglandin E2 receptor EP3 subtype	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Prostaglandin E2 receptor EP2 subtype	Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathway	Prostaglandin E2 receptor EP2 subtype	Homo sapiens (human)
response to nematode	Prostaglandin E2 receptor EP2 subtype	Homo sapiens (human)
response to lipopolysaccharide	Prostaglandin E2 receptor EP2 subtype	Homo sapiens (human)
response to progesterone	Prostaglandin E2 receptor EP2 subtype	Homo sapiens (human)
regulation of cell population proliferation	Prostaglandin E2 receptor EP2 subtype	Homo sapiens (human)
cellular response to prostaglandin E stimulus	Prostaglandin E2 receptor EP2 subtype	Homo sapiens (human)
positive regulation of cytosolic calcium ion concentration	Prostaglandin E2 receptor EP2 subtype	Homo sapiens (human)
inflammatory response	Prostaglandin E2 receptor EP2 subtype	Homo sapiens (human)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	Prostacyclin receptor	Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathway	Prostacyclin receptor	Homo sapiens (human)
cell-cell signaling	Prostacyclin receptor	Homo sapiens (human)
negative regulation of platelet-derived growth factor receptor signaling pathway	Prostacyclin receptor	Homo sapiens (human)
response to lipopolysaccharide	Prostacyclin receptor	Homo sapiens (human)
negative regulation of smooth muscle cell proliferation	Prostacyclin receptor	Homo sapiens (human)
positive regulation of cytosolic calcium ion concentration	Prostacyclin receptor	Homo sapiens (human)
inflammatory response	Prostacyclin receptor	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Prostaglandin D2 receptor	Homo sapiens (human)
male sex determination	Prostaglandin D2 receptor	Homo sapiens (human)
sleep	Prostaglandin D2 receptor	Homo sapiens (human)
mast cell degranulation	Prostaglandin D2 receptor	Homo sapiens (human)
adenosine metabolic process	Prostaglandin D2 receptor	Homo sapiens (human)
cellular response to prostaglandin D stimulus	Prostaglandin D2 receptor	Homo sapiens (human)
positive regulation of cytosolic calcium ion concentration	Prostaglandin D2 receptor	Homo sapiens (human)
inflammatory response	Prostaglandin D2 receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (9)

Process	via Protein(s)	Taxonomy
thromboxane A2 receptor activity	Thromboxane A2 receptor	Homo sapiens (human)
guanyl-nucleotide exchange factor activity	Thromboxane A2 receptor	Homo sapiens (human)
protein binding	Thromboxane A2 receptor	Homo sapiens (human)
D1 dopamine receptor binding	Prostaglandin E2 receptor EP1 subtype	Homo sapiens (human)
prostaglandin E receptor activity	Prostaglandin E2 receptor EP1 subtype	Homo sapiens (human)
prostaglandin E receptor activity	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
protein binding	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
prostaglandin F receptor activity	Prostaglandin F2-alpha receptor	Homo sapiens (human)
prostaglandin E receptor activity	Prostaglandin E2 receptor EP3 subtype	Homo sapiens (human)
prostaglandin E receptor activity	Prostaglandin E2 receptor EP2 subtype	Homo sapiens (human)
guanyl-nucleotide exchange factor activity	Prostacyclin receptor	Homo sapiens (human)
prostacyclin receptor activity	Prostacyclin receptor	Homo sapiens (human)
prostaglandin J receptor activity	Prostaglandin D2 receptor	Homo sapiens (human)
prostaglandin D receptor activity	Prostaglandin D2 receptor	Homo sapiens (human)
protein binding	Prostaglandin D2 receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (8)

Process	via Protein(s)	Taxonomy
acrosomal vesicle	Thromboxane A2 receptor	Homo sapiens (human)
plasma membrane	Thromboxane A2 receptor	Homo sapiens (human)
nuclear speck	Thromboxane A2 receptor	Homo sapiens (human)
plasma membrane	Thromboxane A2 receptor	Homo sapiens (human)
plasma membrane	Prostaglandin E2 receptor EP1 subtype	Homo sapiens (human)
plasma membrane	Prostaglandin E2 receptor EP1 subtype	Homo sapiens (human)
plasma membrane	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
membrane	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
plasma membrane	Prostaglandin E2 receptor EP4 subtype	Homo sapiens (human)
extracellular region	Prostaglandin F2-alpha receptor	Homo sapiens (human)
cytoplasm	Prostaglandin F2-alpha receptor	Homo sapiens (human)
plasma membrane	Prostaglandin F2-alpha receptor	Homo sapiens (human)
plasma membrane	Prostaglandin F2-alpha receptor	Homo sapiens (human)
nuclear envelope	Prostaglandin E2 receptor EP3 subtype	Homo sapiens (human)
plasma membrane	Prostaglandin E2 receptor EP3 subtype	Homo sapiens (human)
membrane	Prostaglandin E2 receptor EP3 subtype	Homo sapiens (human)
plasma membrane	Prostaglandin E2 receptor EP3 subtype	Homo sapiens (human)
plasma membrane	Prostaglandin E2 receptor EP2 subtype	Homo sapiens (human)
plasma membrane	Prostaglandin E2 receptor EP2 subtype	Homo sapiens (human)
cytosol	Prostacyclin receptor	Homo sapiens (human)
plasma membrane	Prostacyclin receptor	Homo sapiens (human)
plasma membrane	Prostacyclin receptor	Homo sapiens (human)
plasma membrane	Prostaglandin D2 receptor	Homo sapiens (human)
membrane	Prostaglandin D2 receptor	Homo sapiens (human)
plasma membrane	Prostaglandin D2 receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (14)

Assay ID	Title	Year	Journal	Article
AID160689	Binding affinity towards EP3 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	2003	Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6	Discovery of a potent and selective agonist of the prostaglandin EP4 receptor.
AID161075	Binding affinity towards EP4 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	2003	Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6	Discovery of a potent and selective agonist of the prostaglandin EP4 receptor.
AID1146116	Binding affinity to prostaglandin receptor in Charles River CD-1 mouse ovary assessed as increase in cAMP accumulation using [8-14C]adenine at 100 ug/ml after 30 mins relative to control	1977	Journal of medicinal chemistry, Oct, Volume: 20, Issue:10	Prostaglandin isosteres. 1. (8-Aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids and their derivatives.
AID160688	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	2003	Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6	Discovery of a potent and selective agonist of the prostaglandin EP4 receptor.
AID1146113	Dissociation constant, pKa of the compound	1977	Journal of medicinal chemistry, Oct, Volume: 20, Issue:10	Prostaglandin isosteres. 1. (8-Aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids and their derivatives.
AID1146115	Binding affinity to prostaglandin receptor in Charles River CD-1 mouse ovary assessed as increase in cAMP accumulation using [8-14C]adenine at 25 ug/ml after 30 mins relative to control	1977	Journal of medicinal chemistry, Oct, Volume: 20, Issue:10	Prostaglandin isosteres. 1. (8-Aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids and their derivatives.
AID161215	Binding affinity towards TP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	2003	Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6	Discovery of a potent and selective agonist of the prostaglandin EP4 receptor.
AID1146112	Retardation factor, Rf of the compound	1977	Journal of medicinal chemistry, Oct, Volume: 20, Issue:10	Prostaglandin isosteres. 1. (8-Aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids and their derivatives.
AID160763	Binding affinity towards IP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	2003	Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6	Discovery of a potent and selective agonist of the prostaglandin EP4 receptor.
AID160705	Binding affinity towards FP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	2003	Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6	Discovery of a potent and selective agonist of the prostaglandin EP4 receptor.
AID160535	Binding affinity towards DP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	2003	Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6	Discovery of a potent and selective agonist of the prostaglandin EP4 receptor.
AID1146114	Binding affinity to prostaglandin receptor in Charles River CD-1 mouse ovary assessed as increase in cAMP accumulation using [8-14C]adenine at 1 ug/ml after 30 mins relative to control	1977	Journal of medicinal chemistry, Oct, Volume: 20, Issue:10	Prostaglandin isosteres. 1. (8-Aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids and their derivatives.
AID160687	Binding affinity towards EP1 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	2003	Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6	Discovery of a potent and selective agonist of the prostaglandin EP4 receptor.
AID1146117	Displacement of [3H-PGE1] from Sprague-Dawley rat kidney prostaglandin receptor after 60 mins by scintillation counting analysis	1977	Journal of medicinal chemistry, Oct, Volume: 20, Issue:10	Prostaglandin isosteres. 1. (8-Aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids and their derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (11.11)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (11.11)	29.6817
2010's	7 (77.78)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
carbachol Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.	2.11	1	ammonium salt; carbamate ester	cardiotonic drug; miotic; muscarinic agonist; nicotinic acetylcholine receptor agonist; non-narcotic analgesic
thiophenes Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.	2.11	1	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent
triazoles Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.	2.11	1	1,2,3-triazole
ay 23626 AY 23626: prostaglandin E2 agonist	1.95	1
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	3.59	8	prostaglandins E	human metabolite; mouse metabolite; oxytocic
alprostadil [no description available]	2.94	4	prostaglandins E	anticoagulant; human metabolite; platelet aggregation inhibitor; vasodilator agent
deamino arginine vasopressin Deamino Arginine Vasopressin: A synthetic analog of the pituitary hormone, ARGININE VASOPRESSIN. Its action is mediated by the VASOPRESSIN receptor V2. It has prolonged antidiuretic activity, but little pressor effects. It also modulates levels of circulating FACTOR VIII and VON WILLEBRAND FACTOR.	2.13	1	heterodetic cyclic peptide	diagnostic agent; renal agent; vasopressin receptor agonist
sulprostone sulprostone: structure	2.11	1	prostanoid
l-161982 L-161982: A prostanoid EP4 receptor antagonist	2.11	1	biphenyls
pituitrin Pituitrin: A substance or extract from the neurohypophysis (PITUITARY GLAND, POSTERIOR).	2.06	1
butaprost butaprost: highly selective prostaglandin receptor agonist; structure given in first source	2.79	3
interleukin-8 Interleukin-8: A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.	2.11	1

Condition	Relationship Strength	Studies
Elevated Cholesterol [description not available]	2.17	1
Hypercholesterolemia A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.	2.17	1
Primary Peritonitis [description not available]	2.11	1
Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	2.11	1
Peritonitis INFLAMMATION of the PERITONEUM lining the ABDOMINAL CAVITY as the result of infectious, autoimmune, or chemical processes. Primary peritonitis is due to infection of the PERITONEAL CAVITY via hematogenous or lymphatic spread and without intra-abdominal source. Secondary peritonitis arises from the ABDOMINAL CAVITY itself through RUPTURE or ABSCESS of intra-abdominal organs.	2.11	1
Acquired Nephrogenic Diabetes Insipidus [description not available]	2.06	1

cay 10580

Description

Cross-References

Synonyms (16)

Roles (1)

Drug Classes (3)

Protein Targets (8)

Inhibition Measurements

Biological Processes (58)

Molecular Functions (9)

Ceullar Components (8)

Bioassays (14)

Research

Studies (9)

Market Indicators

Research Demand Index: 12.97

Study Types

cay 10580

Description

Cross-References

Synonyms (16)

Roles (1)

Drug Classes (3)

Protein Targets (8)

Inhibition Measurements

Biological Processes (58)

Molecular Functions (9)

Ceullar Components (8)

Bioassays (14)

Research

Studies (9)

Market Indicators

Research Demand Index: 12.97

Study Types

Related Drugs (12)

Related Conditions (6)