Page last updated: 2024-11-13
cay 10580
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
CAY 10580: a E-prostanoid EP4 receptor agonist [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid : A pyrrolidin-2-one substituted by 6-carboxyhexyl and 3-hydroxyoctyl groups at positions 1 and 2, respectively. It is a potent prostaglandin EP4 receptor agonist (Ki=35 nM). [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 44269516 |
| CHEMBL ID | 15096 |
| CHEBI ID | 194210 |
| MeSH ID | M0562113 |
Synonyms (16)
| Synonym |
|---|
| 7-[2-(3-hydroxy-octyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid |
| bdbm50125403 |
| CHEMBL15096 , |
| 2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid |
| cay 10580 |
| CHEBI:194210 |
| 64054-40-6 |
| 7-[2-(3-hydroxyoctyl)-5-oxopyrrolidin-1-yl]heptanoic acid |
| cay-10580 |
| cay10580 |
| DTXSID10658096 |
| AKOS027288931 |
| 7-(2-(3-hydroxyoctyl)-5-oxopyrrolidin-1-yl)heptanoic acid |
| CS-0110313 |
| HY-135259 |
| mfcd11976917 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Roles (1)
| Role | Description |
|---|---|
| prostaglandin receptor agonist | An agonist that binds to and activates prostaglandin receptors. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
Drug Classes (3)
| Class | Description |
|---|---|
| pyrrolidin-2-ones | A pyrrolidinone in which the oxo group is at position 2 of the pyrrolidine ring. |
| hydroxy monocarboxylic acid | Any monocarboxylic acid which also contains a separate (alcoholic or phenolic) hydroxy substituent. |
| secondary alcohol | A secondary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
Protein Targets (8)
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Thromboxane A2 receptor | Homo sapiens (human) | Ki | 13.0000 | 0.0006 | 1.2407 | 3.8040 | AID161215 |
| Prostaglandin E2 receptor EP1 subtype | Homo sapiens (human) | Ki | 13.0000 | 0.0091 | 0.6635 | 1.5849 | AID160687 |
| Prostaglandin E2 receptor EP4 subtype | Homo sapiens (human) | Ki | 0.0350 | 0.0001 | 0.4744 | 3.1623 | AID161075 |
| Prostaglandin F2-alpha receptor | Homo sapiens (human) | Ki | 13.0000 | 0.0310 | 3.3803 | 9.9910 | AID160705 |
| Prostaglandin E2 receptor EP3 subtype | Homo sapiens (human) | Ki | 2.0000 | 0.0003 | 1.7081 | 6.8000 | AID160689 |
| Prostaglandin E2 receptor EP2 subtype | Homo sapiens (human) | Ki | 3.0000 | 0.0010 | 0.5448 | 3.0000 | AID160688 |
| Prostacyclin receptor | Homo sapiens (human) | Ki | 13.0000 | 0.0032 | 0.4958 | 6.6280 | AID160763 |
| Prostaglandin D2 receptor | Homo sapiens (human) | Ki | 13.0000 | 0.0006 | 0.4913 | 1.4000 | AID160535 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Biological Processes (58)
Molecular Functions (9)
Ceullar Components (8)
Bioassays (14)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID160689 | Binding affinity towards EP3 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | 2003 | Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6 | Discovery of a potent and selective agonist of the prostaglandin EP4 receptor. |
| AID161075 | Binding affinity towards EP4 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | 2003 | Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6 | Discovery of a potent and selective agonist of the prostaglandin EP4 receptor. |
| AID1146116 | Binding affinity to prostaglandin receptor in Charles River CD-1 mouse ovary assessed as increase in cAMP accumulation using [8-14C]adenine at 100 ug/ml after 30 mins relative to control | 1977 | Journal of medicinal chemistry, Oct, Volume: 20, Issue:10 | Prostaglandin isosteres. 1. (8-Aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids and their derivatives. |
| AID160688 | Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | 2003 | Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6 | Discovery of a potent and selective agonist of the prostaglandin EP4 receptor. |
| AID1146113 | Dissociation constant, pKa of the compound | 1977 | Journal of medicinal chemistry, Oct, Volume: 20, Issue:10 | Prostaglandin isosteres. 1. (8-Aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids and their derivatives. |
| AID1146115 | Binding affinity to prostaglandin receptor in Charles River CD-1 mouse ovary assessed as increase in cAMP accumulation using [8-14C]adenine at 25 ug/ml after 30 mins relative to control | 1977 | Journal of medicinal chemistry, Oct, Volume: 20, Issue:10 | Prostaglandin isosteres. 1. (8-Aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids and their derivatives. |
| AID161215 | Binding affinity towards TP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | 2003 | Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6 | Discovery of a potent and selective agonist of the prostaglandin EP4 receptor. |
| AID1146112 | Retardation factor, Rf of the compound | 1977 | Journal of medicinal chemistry, Oct, Volume: 20, Issue:10 | Prostaglandin isosteres. 1. (8-Aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids and their derivatives. |
| AID160763 | Binding affinity towards IP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | 2003 | Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6 | Discovery of a potent and selective agonist of the prostaglandin EP4 receptor. |
| AID160705 | Binding affinity towards FP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | 2003 | Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6 | Discovery of a potent and selective agonist of the prostaglandin EP4 receptor. |
| AID160535 | Binding affinity towards DP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | 2003 | Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6 | Discovery of a potent and selective agonist of the prostaglandin EP4 receptor. |
| AID1146114 | Binding affinity to prostaglandin receptor in Charles River CD-1 mouse ovary assessed as increase in cAMP accumulation using [8-14C]adenine at 1 ug/ml after 30 mins relative to control | 1977 | Journal of medicinal chemistry, Oct, Volume: 20, Issue:10 | Prostaglandin isosteres. 1. (8-Aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids and their derivatives. |
| AID160687 | Binding affinity towards EP1 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | 2003 | Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6 | Discovery of a potent and selective agonist of the prostaglandin EP4 receptor. |
| AID1146117 | Displacement of [3H-PGE1] from Sprague-Dawley rat kidney prostaglandin receptor after 60 mins by scintillation counting analysis | 1977 | Journal of medicinal chemistry, Oct, Volume: 20, Issue:10 | Prostaglandin isosteres. 1. (8-Aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids and their derivatives. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (9)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 7 (77.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.97
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.97) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 10 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||