Page last updated: 2024-09-27

Sister Joseph's Nodule

Metastatic lesion of the UMBILICUS associated with intra-abdominal neoplasms especially of the GASTROINTESTINAL TRACT or OVARY.

Synonyms(2)

Synonym
Sister Joseph's Nodule
Sister Mary Joseph's Nodule

Research Excerpts

Overview

ExcerptReference
"The Sister Mary Joseph's nodule is an umbilical nodule resulting from the metastasis of malignant tumors in the pelvic and/or abdominal cavity."( Chen, T; Chen, X; Cheng, W; Jiang, Y; Nie, X; Zhong, Y, 2022)

Context

ExcerptReference
"Cases of Sister Mary Joseph's nodule have sporadically been reported."( Hasegawa, H; Kitagawa, Y; Kitasato, K; Kojima, K; Murai, S; Oto, I; Shimizu, H; Yabe, N; Yokose, T; Yoshikawa, T, 2015)

Research

Studies (13)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's11 (84.62)28.8240
2020's2 (15.38)9.53
DrugIndicatedRelationship StrengthStudiesTrials
fluorouracil0low20
khellin0low10
letrozole0low10
oxonic acid0low10
tegafur0low10
deoxycytidine0low10
paclitaxel0low20
capecitabine0low20
triazoles0low10
fluorodeoxyglucose f180low50
carboplatin0low20
s 1 (combination)0low10
technetium tc 99m dimercaptosuccinic acid0low10
levoleucovorin0low10

Protein Targets (198)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
RAR-related orphan receptor gamma3003
TDP1 protein4004
estrogen nuclear receptor alpha3003
Liver carboxylesterase 10001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
acetylcholinesterase2002
phosphopantetheinyl transferase2002
estrogen receptor 2 (ER beta)2002
G3003
cytochrome P450 2D62002
euchromatic histone-lysine N-methyltransferase 22002
vitamin D3 receptor isoform VDRA2002
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
nuclear factor erythroid 2-related factor 2 isoform 12002
DNA polymerase kappa isoform 11001
histone acetyltransferase KAT2A isoform 12002
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 3003
Inositol hexakisphosphate kinase 13003
cytochrome P450 2C9, partial3003
ATP-dependent phosphofructokinase2002
Thymidine kinase 2 0101
Deoxycytidine kinase0001
Probable deoxycytidylate deaminase0001
Cytidine deaminase0001
AAA family ATPase 0001
Reverse transcriptase/RNaseH 0011
Chain A, Uracil Phosphoribosyltransferase0101
Luciferase2002
interleukin 81001
endonuclease IV1001
glp-1 receptor, partial2002
Skn7p0001
thioredoxin reductase2002
pregnane X receptor2002
hypoxia-inducible factor 1 alpha subunit1001
ATAD5 protein, partial1001
GLI family zinc finger 32002
Microtubule-associated protein tau2002
Thrombopoietin1001
AR protein3003
aldehyde dehydrogenase 1 family, member A12002
thyroid stimulating hormone receptor2002
nuclear receptor subfamily 1, group I, member 32002
progesterone receptor1001
EWS/FLI fusion protein2002
nonstructural protein 11001
glucocorticoid receptor [Homo sapiens]2002
retinoic acid nuclear receptor alpha variant 11001
retinoid X nuclear receptor alpha2002
estrogen-related nuclear receptor alpha1001
farnesoid X nuclear receptor1001
pregnane X nuclear receptor2002
67.9K protein2002
peroxisome proliferator-activated receptor delta2002
peroxisome proliferator activated receptor gamma2002
arylsulfatase A1001
IDH12002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
v-jun sarcoma virus 17 oncogene homolog (avian)1001
Histone H2A.x1001
peripheral myelin protein 22 isoform 11001
hemoglobin subunit beta1001
chromobox protein homolog 12002
nuclear factor erythroid 2-related factor 2 isoform 21001
thyroid hormone receptor beta isoform 22002
huntingtin isoform 21001
flap endonuclease 11001
serine/threonine-protein kinase mTOR isoform 11001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
geminin2002
Vpr1001
peripheral myelin protein 223003
survival motor neuron protein isoform d2002
muscleblind-like protein 1 isoform 11001
lamin isoform A-delta103003
ATP-binding cassette sub-family C member 30202
Multidrug resistance-associated protein 40202
Voltage-dependent calcium channel gamma-2 subunit1001
Solute carrier family 22 member 80001
Bile salt export pump0303
Epidermal growth factor receptor0202
Cellular tumor antigen p533003
Amyloid-beta precursor protein1001
Thymidylate synthase0101
Aromatase0303
Glutamate receptor 21001
Canalicular multispecific organic anion transporter 10202
ATPase family AAA domain-containing protein 51001
Ataxin-21001
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
USP1 protein, partial2002
GALC protein1001
cytochrome P450 family 3 subfamily A polypeptide 43003
aryl hydrocarbon receptor1001
cytochrome P450 2D6 isoform 11001
cytochrome P450 2C19 precursor2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
importin subunit beta-1 isoform 11001
mitogen-activated protein kinase 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
cytochrome P450 3A4 isoform 12002
Gamma-aminobutyric acid receptor subunit pi2002
Cytochrome P450 1A10202
Cytochrome P450 1A20202
Cytochrome P450 3A40101
Cytochrome P450 2D60101
Cytochrome P450 2C9 0101
Gamma-aminobutyric acid receptor subunit beta-12002
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
Gamma-aminobutyric acid receptor subunit alpha-62002
Cytochrome P450 2C190101
Gamma-aminobutyric acid receptor subunit alpha-12002
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
Cytochrome P450 1B10101
GABA theta subunit2002
Gamma-aminobutyric acid receptor subunit epsilon2002
runt-related transcription factor 1 isoform AML1b1001
core-binding factor subunit beta isoform 21001
Carbonic anhydrase 20101
Estrogen receptor0101
Steryl-sulfatase0101
Cytochrome P450 11B1, mitochondrial0101
Cytochrome P450 11B2, mitochondrial0101
Amine oxidase [flavin-containing] A 0101
Chain A, Beta-lactamase2002
Genome polyprotein 0101
vitamin D (1,25- dihydroxyvitamin D3) receptor1001
nuclear receptor subfamily 1, group I, member 21001
NPC intracellular cholesterol transporter 1 precursor1001
Tyrosine-protein kinase ABL10101
Tubulin alpha-1A chain0012
Tubulin beta chain0011
Tubulin beta-4A chain0113
Receptor tyrosine-protein kinase erbB-20101
Integrin beta-30101
Tyrosine-protein kinase Fyn0101
Integrin alpha-V 0101
Tubulin beta chain0113
ATP-dependent translocase ABCB10103
60 kDa chaperonin0101
Tubulin alpha-3C chain0113
Botulinum neurotoxin type A 0101
Apoptosis regulator Bcl-20101
60 kDa heat shock protein, mitochondrial0101
Fibroblast growth factor receptor 10101
Proto-oncogene tyrosine-protein kinase Src0101
UDP-glucuronosyltransferase 2B70101
UDP-glucuronosyltransferase 1-60101
ATP-dependent translocase ABCB10101
Substance-K receptor0202
UDP-glucuronosyltransferase 1A1 0101
UDP-glucuronosyltransferase 1A40101
Serum paraoxonase/arylesterase 10101
Cholecystokinin receptor type A0202
Melanocortin receptor 50202
UDP-glucuronosyltransferase 2B10 0101
Delta-type opioid receptor0202
10 kDa heat shock protein, mitochondrial0101
Tubulin alpha-1B chain0113
Tubulin alpha-4A chain0113
Tubulin beta-4B chain0113
Bcl-2-like protein 10101
Tyrosine-protein kinase Mer0101
Tubulin beta-3 chain0214
Tubulin beta-2A chain0113
Thiosulfate sulfurtransferase0101
Beta-tubulin 0101
Tubulin beta-8 chain0113
60 kDa chaperonin 0101
Tubulin beta-2B chain0013
Tubulin alpha-3E chain0113
Tubulin alpha-1A chain0113
10 kDa chaperonin 0101
Similar to alpha-tubulin isoform 1 0013
Similar to alpha-tubulin isoform 1 0002
Tubulin alpha-1C chain0113
Tubulin beta-6 chain0113
Tubulin beta-2B chain0113
Tubulin beta-1 chain0113
Nucleotide-binding oligomerization domain-containing protein 20101
Solute carrier organic anion transporter family member 1B30202
Solute carrier organic anion transporter family member 1B10202
potassium voltage-gated channel subfamily H member 2 isoform d1001
nuclear receptor ROR-gamma isoform 11001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]