Page last updated: 2024-10-14

cardanol

Description

cardanol: from pink pepper; phenol with hydrocarbon side chain which can vary in length & unsaturation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11266523
CHEMBL ID470680
CHEBI ID186661
SCHEMBL ID2290369
MeSH IDM0116093

Synonyms (26)

Synonym
phenol, 3-(8z,11z)-8,11,14-pentadecatrienyl-
CHEMBL470680 ,
5-{8(z),11(z),14-pentadecatrienyl}phenol
37330-39-5
cardanol
79353-39-2
CHEBI:186661
3-[(8z,11z)-pentadeca-8,11,14-trienyl]phenol
bdbm50292426
3-((8z,11z)-pentadeca-8,11,14-trienyl)phenol
unii-9h1349hesu
3-(8z,11z)-8,11,14-pentadecatrien-1-ylphenol
9h1349hesu ,
cardanol triene
phenol, 3-(8,11,14-pentadecatrienyl)-, (z,z)-
JOLVYUIAMRUBRK-UTOQUPLUSA-N
SCHEMBL2290369
3-[(8z,11z)-pentadeca-8,11,14-trien-1-yl]phenol
phenol, 3-(8z,11z)-8,11,14-pentadecatrien-1-yl-
LMPK15010002
3-((8z,11z)-pentadeca-8,11,14-trien-1-yl)phenol
DTXSID00872880
Q27896120
(8z,11z)-3-(8,11,14-pentadecatrienyl)phenol
3-(8z,11z)-8,11,14-pentadecatrien-1-yl-phenol
AKOS040755901

Research Excerpts

Overview

Cardanol is a natural alkylphenolic compound derived from Cashew NutShell Liquid (CNSL), a non-food annually renewable raw material extracted from cashew nutshells. It is a potential chemotherapeutic agent for breast cancer.

ExcerptReference
"Cardanol-formaldehyde is an environmentally friendly adhesive made with cashew nut liquid, a byproduct from the cashew chain."( Cardanol-based adhesive with reduced formaldehyde emission to produce particleboards with waste from bean crops.
de Carvalho, LMH; de Oliveira, JE; de Paula Protásio, T; Faria, DL; Gonçalves, FG; Junior, JBG; Lelis, RCC; Mendes, LM; Scatolino, MV; Soriano, J, 2023
)
"Cardanol is a natural alkylphenolic compound derived from Cashew NutShell Liquid (CNSL), a non-food annually renewable raw material extracted from cashew nutshells. "( Photocuring of Epoxidized Cardanol for Biobased Composites with Microfibrillated Cellulose.
Bongiovanni, R; Dalle Vacche, S; Vitale, A, 2019
)
"Cardanol is a plant-based renewable raw material, readily obtained from Cashew Nut Shell Liquid (CNSL)."( Self-assembly of novel Fmoc-cardanol compounds into hydrogels - analysis based on rheological, structural and thermal properties.
Abraham, JN; Joseph, S; Kadeeja, A, 2020
)
"Cardanol is a constituent of Cashew Nut Shell Liquid that presents larvicidal activity against Aedes aegypti. "( A potent larvicidal agent against Aedes aegypti mosquito from cardanol.
Arruda, EJ; Avvari, NP; Beatriz, A; Biaggio, FC; Cabrini, I; Lima, DP; Marques, MR; Paiva, DR; Sangi, DP; Santos, EAD, 2017
)
"Cardanol is a non-isoprenoic phenolic lipid-mixture of distilled cashew nut shell liquid obtained from Anacardium occidentale. "( Self-assembled cardanol azo derivatives as antifungal agent with chitin-binding ability.
Bharti, R; Gupta, VK; Mahata, D; Mandal, M; Mandal, SM; Nag, A; Nando, GB, 2014
)
"Cardanol is a renewable, low cost natural material, widely available as a by-product of the cashew industry. "( Cardanol-based materials as natural precursors for olefin metathesis.
Del Sole, R; Mele, G; Vasapollo, G, 2011
)
"Cardanol is a potential chemotherapeutic agent for breast cancer."( Cardanol isolated from Thai Apis mellifera propolis induces cell cycle arrest and apoptosis of BT-474 breast cancer cells via p21 upregulation.
Buahorm, S; Chanchao, C; Lirdprapamongkol, K; Palaga, T; Phuwapraisirisan, P; Puthong, S; Svasti, J, 2015
)
"Cardanol is a phenolic lipid component of cashew nut shell liquid (CNSL), obtained as the byproduct of cashew nut food processing. "( Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease.
Andrisano, V; Bartolini, M; Bolognesi, ML; Brand, GD; Castro, NG; da Silva Boni, M; da Silva, FMR; de Andrade Ramos, G; de Castro Couto, G; de Oliveira, AS; do Nascimento Nogueira, PC; Guimarães, MJR; Korábečný, J; Lemes, LFN; Romeiro, LAS; Romeiro, NC; Silveira, ER; Soukup, O; Souza, INO, 2016
)
"Cardanol is a natural and renewable organic raw material obtained as the major chemical component by vacuum distillation of cashew nut shell liquid. "( First example of a lipophilic porphyrin-cardanol hybrid embedded in a cardanol-based micellar nanodispersion.
Bloise, E; Carbone, L; Colafemmina, G; D'Accolti, L; Mazzetto, SE; Mele, G; Vasapollo, G, 2012
)
"Cardanol is a renewable raw material derived from a byproduct of cashew nut processing industry: Cashew Nut Shell Liquid (CNSL)."( Recent advances in cardanol chemistry in a nutshell: from a nut to nanomaterials.
Balachandran, VS; Jadhav, SR; John, G; Vemula, PK, 2013
)
"Cardanol is a phenol derivative from a renewable resource mainly having a C15 unsaturated hydrocarbon chain with mostly 1-3 double bonds at a meta position."( Horseradish peroxidase-catalyzed polymerization of cardanol in the presence of redox mediators.
An, ES; Kim, YH; Lee, YS; Song, BK; Won, K,
)

Toxicity

ExcerptReference
" Based on this, the present research evaluated the toxic effects of both compounds in different biological models through the investigation of survival and mortality percentages as a measure of acute toxicity on Daphnia similis and Oreochromis niloticus, larvicidal assay against Aedes aegypti, and cytotoxic activity on mammary cells."( Assessment of acute toxicity and cytotoxicity of fluorescent markers produced by cardanol and glycerol, which are industrial waste, to different biological models.
Antoniolli-Silva, ACMB; Beatriz, A; Braga, FC; Crispim, BDA; de Barros, LGML; de Lima, DP; de Souza, AP; Dos Santos Jaques, JA; Grisolia, AB; Oliveira, EJT; Oliveira, RJ; Pelizaro, BI; Pessatto, LR; Vani, JM, 2019
)

Dosage Studied

ExcerptReference
" The effects of degree of lignin depolymerization, chemical composition of lignin oligomers and dosage of ECGE on thermal and mechanical properties of the cured products were investigated."( Preparation and properties of novel bio-based epoxy resin thermosets from lignin oligomers and cardanol.
Chu, F; Huo, S; Jin, C; Kong, Z; Liu, G, 2021
)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
phenolsOrganic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID332455Inhibition of mushroom tyrosinase assessed as oxidation of L-DOPA at 0.8 mM1994Journal of natural products, Apr, Volume: 57, Issue:4
Tyrosinase inhibitors from Anacardium occidentale fruits.
AID348953Antibacterial activity against Escherichia coli ATCC 9637 up to 200 ug/ml after 2 days by twofold broth dilution method2008European journal of medicinal chemistry, Jun, Volume: 43, Issue:6
Design and evaluation of anacardic acid derivatives as anticavity agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (66)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (4.55)18.7374
1990's1 (1.52)18.2507
2000's12 (18.18)29.6817
2010's32 (48.48)24.3611
2020's18 (27.27)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (2.94%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other66 (97.06%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]