triazoles has been researched along with 1-aminobenzotriazole in 186 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (4.30) | 18.7374 |
| 1990's | 46 (24.73) | 18.2507 |
| 2000's | 60 (32.26) | 29.6817 |
| 2010's | 70 (37.63) | 24.3611 |
| 2020's | 2 (1.08) | 2.80 |
| Authors | Studies |
|---|---|
| Bend, JR; Knickle, LC | 2 |
| Haas, AL; Koop, DR; Tierney, DJ | 1 |
| Decker, CJ; Doerge, DR | 1 |
| Mico, BA; Mortillo, M; Mugford, CA; Tarloff, JB | 1 |
| Garland, WA; Mico, BA; Mortillo, M; Oldfield, NF | 1 |
| Chang, SW; Dutton, D; Giacomini, KM; He, LS; Hui, A; Ortiz de Montellano, P; Stearns, R; Voelkel, NF; Wang, HL | 1 |
| Covington, MO; Nichols, WK; Safiullah, S; Seiders, CD; Yost, GS | 1 |
| Clark, JE; Harder, DR; Kauser, K; Ma, YH; Masters, BS; Ortiz de Montellano, PR; Roman, RJ | 1 |
| Catto, L; Jones, RB; Leonard, T; Poole, A; Pritchard, D | 2 |
| Chang, S; Czartalomna, J; Feddersen, CO; Voelkel, NF | 1 |
| Larson, DN; Nichols, WK; Yost, GS | 1 |
| Bend, JR; Woodcroft, KJ | 1 |
| Mackie, JE; Marks, GS; Massey, TE; Riddick, DS | 1 |
| Federowicz, DA; Kerns, W; Mico, BA; Ripple, MG | 1 |
| Bend, JR; Mathews, JM | 2 |
| Costa, AK; Ortiz de Montellano, PR | 1 |
| Ortiz de Montellano, PR; Reich, NO | 1 |
| Bend, JR; Dostal, LA; Mathews, JM | 1 |
| Durst, F; Mathews, JM; Ortiz de Montellano, PR; Reichhart, D; Simon, A | 1 |
| Mathews, JM; Ortiz de Montellano, PR | 1 |
| Colby, HD; Mico, BA; Voigt, JM; Xu, D | 1 |
| Bend, JR; Grimm, SW; Halpert, JR | 1 |
| Mugford, CA; Tarloff, JB | 2 |
| Abbott, B; Cachovic, M; Colby, HD; Debolt, KM; Mico, BA | 1 |
| Colby, HD; Kominami, S; Mico, BA; Takemori, S; Voigt, JM; Xu, D | 1 |
| Bend, JR; Knickle, LC; Philpot, RM | 1 |
| Feldman, D; Garland, WA; Kaufman, LS; Meschter, CL; Mico, BA; Mortillo, M; Riley, JA | 1 |
| Bend, JR; House, AA; Knickle, LC; Webb, CD | 1 |
| Fry, JR; Hammond, AH | 1 |
| Chang, D; Garland, W; Henderson, L; Mortillo, M; Town, C | 1 |
| Amore, BM; Bennett, GD; Finnell, RH; Kalhorn, TF; Lillibridge, JH; Nelson, SD; Slattery, JT | 1 |
| Coceani, F; Kelsey, L; Korzekwa, K; Seidlitz, E | 1 |
| Hatton, CJ; Peers, C | 2 |
| Fry, JR; Garle, MJ; Hammond, AH | 1 |
| Novak, RF; Zangar, RC | 1 |
| Bend, JR; Webb, CD; Weedon, AC; Woodcroft, KJ; Yao, M | 1 |
| Bart, JA; DeLeve, LD; Kaplowitz, N; Shulman, HM; van der Hoek, A; Wang, X | 1 |
| Van de Voorde, J; Vanheel, B | 1 |
| Ring, SC; Shao, R; Tarloff, JB | 1 |
| Colby, HD; Soltis, M | 1 |
| Davis, SC; Dierks, EA; Ortiz de Montellano, PR | 1 |
| Kaushal, KM; Kroetz, DL; Su, P | 1 |
| de Montellano, PR; Dierks, EA; Johnson, EF; Zhang, Z | 1 |
| Branch, RA; Carcillo, JA; Gillespie, DG; Jones, GS; Kochanek, PM; Korzekwa, KR; Kost, CK; Parise, RA; Whalen, MJ | 1 |
| Carlile, DJ; Hakooz, N; Houston, JB | 1 |
| Morgan, JA; Shanks, JV | 1 |
| Lin, EH; Marks, GS; Wong, SG | 1 |
| Di Re, J; Lee, C; Riddick, DS | 1 |
| Hahn, ME; Kerkvliet, NI; Lawrence, BP; Mann, KK; Matulka, RA; Sherr, DH; Trombino, AF | 1 |
| Behne, M; de Montellano, PO; Elias, PM; Holleran, WM; Seki, T; Uchida, Y | 1 |
| Bend, JR; Moorthy, B; Parker, KM; Smith, CV; Welty, SE | 1 |
| Adler, ID; Baumgartner, A; Friedman, MA; Gonda, H; Skerhut, M | 1 |
| Jackson, TE; Lilly, PD; Medinsky, MA; Recio, L; Schlosser, PM | 1 |
| Alaoui El Azher, M; Dumarey, C; Havet, N; Singer, M; Touqui, L | 1 |
| Begay, CK; Gandolfi, AJ; Lind, RC | 1 |
| Alonso-Galicia, M; Falck, JR; Henderson, L; Maier, KG; Narayanan, J; Roman, RJ | 1 |
| Saxena, NC | 1 |
| Benter, IF; Estes, A; Gaber, L; Karzoun, NA; Khandekar, Z; Malik, KU; Muthalif, MM; Parmentier, JH; Saeed, AE | 1 |
| Hamm, JT; Hinton, DE; Wilson, BW | 1 |
| Chiribiri, A; Gattullo, D; Pagliaro, P; Paolocci, N; Penna, C; Rastaldo, R | 1 |
| Fenoy, FJ; López, B; Moreno, C; Roman, RJ; Salom, MG | 1 |
| Laniado-Schwartzman, M; Nasjletti, A; Wang, MH; Zand, BA | 1 |
| Friedman, MA; Kamendulis, LM; Klaunig, JE; Park, J | 1 |
| Kamendulis, LM; Klaunig, JE; Zhang, H | 1 |
| Alonso-Galicia, M; Cowley, AW; Greene, AS; Maier, KG; Roman, RJ | 1 |
| Balani, SK; He, B; Lee, FW; Liu, Z; Yang, TJ; Zhu, T | 1 |
| Burchiel, SW; Carr, BA; Macé, K; Mehta, R; Minko, T; Nichols, WK; Pfeifer, AM; Skordos, K; Yost, GS | 1 |
| Crouch, DJ; Ehlhardt, WJ; Espina, RJ; Jackson, DA; Kulanthaivel, P; Moody, DE; Mutlib, AE; Reilly, CA; Yost, GS | 1 |
| El-Masri, HA; Ghanayem, BI; Hoffler, U | 1 |
| Kitano, S; Kondo, R; Mori, T | 1 |
| Abbott, FS; Chang, TK; Chen, J; Tong, V | 1 |
| Długoński, J; Lisowska, K | 1 |
| Flasch, AK; Hoagland, KM; Roman, RJ | 1 |
| Adams, TB; Lake, BG; Phillips, JC; Price, RJ; Walters, DG; Young, PJ | 1 |
| Arteel, GE; Bradford, BU; Connor, HD; Froh, M; Isayama, F; Kadiiska, MB; Koop, DR; Mason, RP; McKim, SE; Wheeler, MD | 1 |
| Alexander, BT; Capparelli, MF; Carroll, MA; Granger, JP; Llinás, MT | 1 |
| Dahly-Vernon, AJ; Dos Santos, EA; Hoagland, KM; Roman, RJ | 1 |
| Balani, SK; Cardoza, K; Gan, LS; Lee, FW; Li, P; Mu, DX; Nguyen, J; Wu, JT; Zeng, H | 1 |
| Crisafulli, A; Gattullo, D; Losano, G; Mancardi, D; Pagliaro, P; Penna, C; Rastaldo, R | 1 |
| Jiang, J; Kamendulis, LM; Kaster, J; Klaunig, JE; Lafferty, JS | 1 |
| Morgan, ET | 1 |
| Akhtar, S; Benter, IF; Canatan, H; Yousif, MH | 1 |
| Chiu, PY; Ko, KM; Mak, DH; Poon, MK | 1 |
| Cowley, AW; Ito, O; Ito, S; Kohzuki, M; Mori, T; Roman, RJ; Sarkis, A; Verbalis, J | 1 |
| Benter, IF; Canatan, H; Cojocel, C; Francis, I; Juggi, JS; Yousif, MH | 1 |
| Kondo, Y; Mitsukura, K; Nagasawa, T; Yoshida, T | 1 |
| Hur, HG; Kanaly, RA | 1 |
| Emoto, C; Iwasaki, K; Murase, S; Sawada, Y | 1 |
| Basha, SJ; Mullangi, R; Muzeeb, S; Pasha, MK; Srinivas, NR | 1 |
| Estes, A; Malik, KU; Tunctan, B; Yaghini, FA | 1 |
| Fisher, MB; Foti, RS; Strelevitz, TJ | 1 |
| Bellward, GD; Chang, TK; Levine, M; Madeira, M; Mirfazaelian, A | 1 |
| Blanton, A; Hercule, H; Nsaif, R; Oyekan, A | 1 |
| Wu, SH; Yeh, SL | 1 |
| Antholz, M; Francke, W; Kokova, M; Li, R; Müller, R; Nagorny, S; Rappert, S | 1 |
| Flasch, AK; Lopez, B; Roman, RJ; Ryan, RP; Sarkis, A; Williams, JM | 1 |
| Badzyńska, B; Kompanowska-Jezierska, E; Kuczeriszka, M | 1 |
| Dobrowolski, L; Kompanowska-Jezierska, E; Kuczeriszka, M; Sadowski, J; Walkowska, A | 1 |
| Adinarayana Reddy, C; Caminal, G; Gabarrell, X; Marco-Urrea, E; Parella, T; Vicent, T | 1 |
| Ballard, P; Barlaam, BC; Bradbury, RH; Dishington, A; Hennequin, LF; Hickinson, DM; Hollingsworth, IM; Kettle, JG; Klinowska, T; Ogilvie, DJ; Pearson, SE; Scott, JS; Suleman, A; Whittaker, R; Williams, EJ; Wood, R; Wright, L | 1 |
| Baillie, TA; Bleasby, K; Chen, Q; Colletti, A; Dean, DC; Evers, R; Hafey, M; Hagmann, WK; Lanza, TJ; Lin, LS; Magriotis, PA; Stearns, RA; Tang, W; Teffera, Y | 1 |
| Chen, J; Mannargudi, BM; Uetrecht, J; Xu, L | 1 |
| Clarke, SE; Hollis, FJ; Maggs, JL; Naisbitt, DJ; Park, BK; Sanderson, JP | 1 |
| Hutzler, JM; Linder, CD; Renaud, NA | 1 |
| Deshmukh, SV; Durston, J; Shomer, NH | 1 |
| Akhtar, S; Benter, IF; Dahly-Vernon, AJ; Dunn, KM; Roman, RJ; Yousif, MH | 1 |
| Brodfuehrer, J; Buchholz, L; Clark, A; El-Kattan, AF; Poe, J; Thomas, HV | 1 |
| Glatt, H; Liu, Y | 1 |
| Badzyńska, B; Sadowski, J | 1 |
| Fu, N; Li, LX; Liang, BL; Nan, YM; Wang, RQ; Wu, WJ; Yu, J; Zhao, JM; Zhao, SX | 1 |
| Dowle, A; Grogan, G; Marriott, R; Thompson, ML | 1 |
| Blánquez, P; Caminal, G; Marco-Urrea, E; Pérez-Trujillo, M; Vicent, T | 1 |
| Igeta, K; Suzuki, N; Takahashi, M; Washio, T; Yamashita, S | 1 |
| Hata, T; Kawai, S; Nishida, T; Okamura, H | 1 |
| Bauman, JN; Chen, Y; Eng, H; Kalgutkar, AS; McDonald, TS; Niosi, M; Simila, ST; Warmus, J; Wolford, A | 1 |
| Blair, IA; Christmas, P; Cooper, PR; Douaidy, K; Mesaros, AC; Mittelman, MA; Panettieri, RA; Soberman, RJ; Stark, CM; Zhang, J | 1 |
| Bartrow, H; Hahn, V; Lindequist, U; Mikolasch, A; Schauer, F; Wende, K | 1 |
| Jeong, H; Koh, KH; Yang, K | 1 |
| Atsumi, R; Izumi, T; Nakazawa, T; Okazaki, O; Saji, H; Shimizu, S; Sudo, K | 1 |
| Aghofack-Nguemezi, J; Fuchs, C; Hoffmann, T; Huang, FC; Schwab, W; Yeh, SY | 1 |
| Song, J; Wan, Y; Zhang, L; Zhang, X; Zhu, C | 1 |
| Baker, R; Davis, DD; Fan, F; Lima, R; Moulana, M; Reckelhoff, JF; Roman, RJ; Romero, DG; Ryan, MJ; Yanes, LL; Yuan, K; Zhang, H | 1 |
| Jain, GK; Manickavasagam, L; Mishra, S | 1 |
| Greenhaw, J; Salminen, WF; Shi, Q; Yang, X | 1 |
| Chang, S; Dierks, EA; Harper, TW; Marathe, P; Rodrigues, AD; Sun, Q; Zhang, L | 1 |
| Doshi, U; Li, AP | 1 |
| Brock, B; Ly, VT | 1 |
| Aper, J; Bulcke, R; Callebaut, G; De Kimpe, N; Deforce, D; Heyerick, A; Mangelinckx, S; Mechant, E; Reheul, D; Rubin, B | 1 |
| Adrian, L; Marco-Urrea, E; Möder, M; Prieto, A; Rodil, R | 1 |
| Kevin Park, B; Priestley, CC; Regan, S; Williams, DP | 1 |
| Bi, YA; El-Kattan, AF; Fenner, KS; Iseki, K; Kimoto, E; Lai, Y; Linder, C; Walsky, R; Whalen, KM; Xiao, Y; Yang, YS; Zhang, H | 1 |
| Cutillas, B; Hernández-Mir, G; Llorens, J; Saldaña-Ruíz, S; Sedó-Cabezón, L | 1 |
| Fernandez, MM; Gonzalez, D; Nowicki, S; Roman, RJ; Williams, JM | 1 |
| LaForge, YS; Li, AP; Uzgare, A | 1 |
| Jiao, SY; Li, AF; Li, H; Shen, GL; Wang, Q | 1 |
| Abbott, FS; Chang, TK; Surendradoss, J | 1 |
| Budha, N; Hop, CE; Khojasteh, SC; Lyssikatos, J; Mulder, T; Rudewicz, PJ; Solon, E; Ware, JA; Wong, H; Yue, Q | 1 |
| Bueters, T; Bylund, J | 1 |
| Lehmler, HJ; Schnoor, JL; Zhai, G | 1 |
| Chen, H; Sang, S; Soroka, D; Zhu, Y | 1 |
| Kubickova, B; Martinkova, M; Stiborova, M | 1 |
| Choi, IG; Hong, CY; Kim, HY; Kim, SH; Lee, SM; Lee, SY | 1 |
| Baker, RC; Chen, BB; Fan, F; Johnson, DA; Liu, H; Orozco, LD; Perkins, E; Roman, RJ | 1 |
| Du, F; Li, X; Liu, Z; Xing, J | 1 |
| Annaert, P; Augustijns, P; Fattah, S; Stappaerts, J | 1 |
| Ford, KA; Halladay, JS; Hop, CE; Khojasteh, SC; Mukadam, S; Sodhi, JK; Wong, S | 1 |
| Jinno, N; Tagashira, M; Tsurui, K; Yamada, S | 1 |
| Lavan, P; Medhurst, S; Sohal, B; Stringer, RA; Tigani, B; Weber, E | 1 |
| Anby, MU; Benameur, H; Feeney, OM; Nguyen, TH; Porter, CJ; Pouton, CW; Williams, HD; Yeap, YY | 1 |
| Almon, V; James, CA; Meyer, J; Pham, R; Ponce, M; Primack, R; Retter, MW; Salyers, KL; Soto, M; Wagner, M | 1 |
| Nezasa, K; Ogawa, K; Shimizu, R; Takai, N; Tanaka, Y; Watanabe, A; Watari, R; Yamaguchi, Y | 1 |
| Fukami, T; Nakajima, M; Oda, S; Takai, S; Tsuneyama, K; Yokoi, T | 1 |
| Červenka, L; Dobrowolski, L; Hammock, BD; Kompanowska-Jezierska, E; Kuczeriszka, M; Olszyñski, KH; Sadowski, J; Walkowska, A | 1 |
| Armel, GR; Best, MD; Brosnan, JT; Elmore, MT; Kopsell, DA; Mueller, TC; Sorochan, JC | 1 |
| Boily, MO; Boudreau, C; Chauret, N; Duquet, MC; Laterreur, J; Leblond, FA; Lévesque, JF; Pichette, V; Ste-Marie, L | 1 |
| Glatt, H; Jin, G; Lai, Y; Liu, Y; Wei, Q; Zhang, C | 1 |
| Chen, J; Ho, Q; Jaochico, A; Ly, J; Mao, J; Mukadam, S; Parrish, KE; Wright, M | 1 |
| Byers, FW; Crouch, RD; Daniels, JS; Emmitte, KA; Lindsley, CW; Morrison, RD | 1 |
| Allan Jaochico, M; Cass, RT; Chen, JZ; Crawford, JJ; Cyrus Khojasteh, S; Durk, M; Fan, PW; La, H; Lee, W; Liu, N; Liu, S; Messick, K; Mulder, T; Murray, LJ; Rudolf, J; Valle, N; Wright, M | 1 |
| Blobaum, AL; Cheung, YY; Conn, PJ; Daniels, JS; Gogliotti, RD; Hopkins, CR; Lindsley, CW; Loch, MT; Morrison, RM; Niswender, CM; Rodriguez, AL; Salovich, JM | 1 |
| Ferreira, S; Ronseaux, S; Rose, J; Stringer, RA | 1 |
| Mayumi, K; Nishimura, K; Osaki, H; Watanabe, A | 1 |
| Chang, J; Garner, CE; Huang, C; Ichihara, G; Ichihara, S; Ito, H; Kato, M; Sakurai, T; Toyokuni, S; Zhang, L; Zhang, X; Zong, C | 1 |
| Korzekwa, K; Kulkarni, P; Nagar, S | 1 |
| Higashino, H; Kataoka, M; Kojima, C; Minami, K; Mutaguchi, K; Sakuma, S; Togashi, K; Ueda, K; Yamashita, S | 1 |
| Khan, AA; LeDuc, BW; Shaik, AN | 1 |
| Ejiri, Y; Kotake, Y; Ohta, S; Ohtsuki, Y; Sanoh, S; Santoh, M | 1 |
| Fang, Y; Hammock, BD; Morisseau, C; Rock, DA; Teague, J; Wang, Z; Wong, H | 1 |
| Bando, K; Ito, K; Nakagawa, T; Ogimura, E; Sekine, S; Tokizono, M | 1 |
| Gu, C; Jones, BC; Markandu, R; Scarfe, G | 1 |
| Ishimura, M; Iwaki, M; Tomida, T | 1 |
| Abla, N; Haas, H; Keiser, J; Reimers, N; Spangenberg, T; Vargas, M | 1 |
| Bednarek, P; Kwaaitaal, M; Panstruga, R; Schaffrath, U; Strugala, R; Wu, H | 1 |
| Afatsawo, C; Arabin, P; Bigaud, M; Cordier, V; Desrayaud, S; Hoffmann, L; Lehmann, D; Lowe, PJ; Risser, F; Stringer, R; Thiel, J; Widmer, T; Wipfli, P | 1 |
| Ajjala, DR; Boggavarapu, RK; Manoharan, AK; Molgara, P; Nirogi, R; Palacharla, RC; Panthangi, HR; Ponnamaneni, RK | 1 |
| Bracht, A; Brugnari, T; Castoldi, R; Coelho-Moreira, JDS; de Souza, CGM; Peralta, RM; Sá-Nakanishi, AB | 1 |
| Gupta, YK; Holenarsipur, VK; Kaur, H; Mariappan, TT; Padmanabhan, S; Rao, A; Saxena, A | 1 |
| de Melo Souza, PL; Murphy, CD; Palmer-Brown, W | 1 |
| Fu, J; Liang, T; Liu, L; Liu, T; Wang, B; Yang, L; Zhan, J; Zhao, S; Zhu, L | 1 |
| Ambhore, SR; Goyal, VK; Londhe, S; Nakka, H; Nirogi, R; Pandey, SK | 1 |
| Halladay, JS; Sodhi, JK | 1 |
186 other study(ies) available for triazoles and 1-aminobenzotriazole
| Article | Year |
|---|---|
Dose-dependent, mechanism-based inactivation of cytochrome P450 monooxygenases in vivo by 1-aminobenzotriazole in liver, lung, and kidney of untreated, phenobarbital-treated, and beta-naphthoflavone-treated guinea pigs.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Guinea Pigs; Isoenzymes; Kidney; Liver; Lung; Male; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Triazoles | 1992 |
Degradation of cytochrome P450 2E1: selective loss after labilization of the enzyme.
Topics: Acetone; Alkylation; Amino Acid Sequence; Aminopyrine N-Demethylase; Animals; Carbon Tetrachloride Poisoning; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Cytochromes b5; Endoplasmic Reticulum; Ligands; Male; Mice; Mixed Function Oxygenases; Molecular Sequence Data; Oxidoreductases, N-Demethylating; Protein Denaturation; Time Factors; Triazoles; Ubiquitins | 1992 |
Covalent binding of 14C- and 35S-labeled thiocarbamides in rat hepatic microsomes.
Topics: Animals; Antithyroid Agents; Benzimidazoles; Biotransformation; Carbon Radioisotopes; Dexamethasone; Glutathione; Male; Methimazole; Microsomes, Liver; NADP; Oxygenases; Rats; Rats, Inbred Strains; Serum Albumin, Bovine; Sulfhydryl Compounds; Sulfur Radioisotopes; Triazoles | 1992 |
1-Aminobenzotriazole-induced destruction of hepatic and renal cytochromes P450 in male Sprague-Dawley rats.
Topics: Animals; Cytochrome P-450 Enzyme System; Glucuronates; Glutathione; In Vitro Techniques; Kidney; Liver; Male; Microsomes; Rats; Rats, Sprague-Dawley; Triazoles | 1992 |
Inhibition of hepatic and cutaneous biotransformation of resorufin ethers following intraperitoneal administration of 1-aminobenzotriazole.
Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Dealkylation; Ethers; Injections, Intraperitoneal; Male; Mice; Microsomes, Liver; Oxazines; Skin; Triazoles | 1992 |
Intact lung cytochrome P-450 is not required for hypoxic pulmonary vasoconstriction.
Topics: Angiotensin II; Animals; Aorta; Chloramphenicol; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Electric Stimulation; Hypoxia; In Vitro Techniques; Lung; Male; Metyrapone; Papillary Muscles; Pulmonary Circulation; Rabbits; Rats; Triazoles; Vasoconstriction | 1992 |
Bioactivation of halogenated hydrocarbons by rabbit pulmonary cells.
Topics: Animals; Cell Survival; Cytochrome P-450 Enzyme System; Dichlorodiphenyldichloroethane; Enzyme Activation; Ethylene Dibromide; Female; Lung; Macrophages, Alveolar; Male; Rabbits; Triazoles; Trichloroethylene | 1992 |
Inhibitors of cytochrome P-450 attenuate the myogenic response of dog renal arcuate arteries.
Topics: Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Dogs; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Hydrazines; Indomethacin; Ketoconazole; Kinetics; Muscle, Smooth, Vascular; Phospholipases A; Phospholipases A2; Phosphorylcholine; Proadifen; Renal Artery; Triazoles | 1991 |
In vivo biliary excretion and in vitro cellular accumulation of thyroxine by rats or cultured rat hepatocytes treated with a novel histamine H1-receptor antagonist.
Topics: Animals; Bile; Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Female; Histamine H1 Antagonists; Liver; Pyrimidinones; Rats; Rats, Inbred Strains; Temperature; Thyroxine; Triazoles; Triiodothyronine | 1990 |
Arachidonic acid causes cyclooxygenase-dependent and -independent pulmonary vasodilation.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Hypoxia; In Vitro Techniques; Male; Perfusion; Prostaglandin-Endoperoxide Synthases; Pulmonary Circulation; Rats; Rats, Inbred Strains; Thromboxane B2; Triazoles; Vasodilation | 1990 |
Bioactivation of 3-methylindole by isolated rabbit lung cells.
Topics: Animals; Biotransformation; Cell Survival; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; In Vitro Techniques; Kinetics; Lung; Macrophages; Male; Mice; Rabbits; Skatole; Triazoles | 1990 |
N-aralkylated derivatives of 1-aminobenzotriazole as isozyme-selective, mechanism-based inhibitors of guinea pig hepatic cytochrome P-450 dependent monooxygenase activity.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Female; Guinea Pigs; Isoenzymes; Kinetics; Liver; Male; Microsomes, Liver; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Triazoles | 1990 |
3,5-Diethoxycarbonyl-2,6-dimethyl-4-ethyl-1,4-dihydropyridine inactivates rat liver cytochrome P-450c, but not its orthologue, rabbit lung form 6.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Dicarbethoxydihydrocollidine; Dihydropyridines; Heme; In Vitro Techniques; Isoenzymes; Liver; Lung; Male; Microsomes; Rabbits; Rats; Species Specificity; Triazoles | 1990 |
In vitro accumulation of thyroid hormones by cultured rat hepatocytes and the biliary excretion of iodothyronines in rats treated with a novel histamine H2-receptor antagonist.
Topics: Animals; Bile; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Histamine H2 Antagonists; Liver; Male; Phenobarbital; Pyrimidinones; Rats; Rats, Inbred Strains; Temperature; Thyroid Hormones; Thyroxine; Triazoles; Triiodothyronine | 1989 |
In vivo inhibition of oxidative drug metabolism by, and acute toxicity of, 1-aminobenzotriazole (ABT). A tool for biochemical toxicology.
Topics: Acetaminophen; Animals; Antipyrine; Biotransformation; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Oxidation-Reduction; Phenacetin; Rats; Triazoles | 1988 |
N-alkylaminobenzotriazoles as isozyme-selective suicide inhibitors of rabbit pulmonary microsomal cytochrome P-450.
Topics: Alkylation; Animals; Benzphetamine; Cytochrome P-450 Enzyme Inhibitors; Isoenzymes; Lung; Male; Microsomes; NADP; Oxazines; Oxygenases; Rabbits; Rats; Rats, Inbred Strains; Triazoles | 1986 |
Dissociation of cytochrome P-450 inactivation and induction.
Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Isoenzymes; Male; Microsomes, Liver; Phenobarbital; Protein Biosynthesis; Rats; Rats, Inbred Strains; RNA, Messenger; Triazoles | 1986 |
Dissociation of increased lauric acid omega-hydroxylase activity from the antilipidemic action of clofibrate.
Topics: Animals; Clofibrate; Cytochrome P-450 CYP4A; Fatty Acids; Fatty Acids, Unsaturated; Hydroxylation; Liver; Male; Mixed Function Oxygenases; Perfusion; Rats; Rats, Inbred Strains; Triazoles; Triglycerides | 1986 |
Inactivation of rabbit pulmonary cytochrome P-450 in microsomes and isolated perfused lungs by the suicide substrate 1-aminobenzotriazole.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Isoenzymes; Lung; Male; Microsomes; NADP; Oxidoreductases; Oxidoreductases, N-Demethylating; Oxygenases; Perfusion; Rabbits; Stereoisomerism; Triazoles | 1985 |
Autocatalytic inactivation of plant cytochrome P-450 enzymes: selective inactivation of cinnamic acid 4-hydroxylase from Helianthus tuberosus by 1-aminobenzotriazole.
Topics: Cytochrome P-450 Enzyme System; In Vitro Techniques; Kinetics; Microsomes; Mixed Function Oxygenases; Plants; Trans-Cinnamate 4-Monooxygenase; Triazoles | 1982 |
Autocatalytic alkylation of the cytochrome P-450 prosthetic haem group by 1-aminobenzotriazole. Isolation of an NN-bridged benzyne-protoporphyrin IX adduct.
Topics: Alkylation; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochromes; Cytochromes b5; Heme; In Vitro Techniques; Macromolecular Substances; Male; Microsomes, Liver; Protoporphyrins; Rats; Rats, Inbred Strains; Spectrophotometry; Triazoles | 1981 |
Inhibition of adrenal steroid metabolism by administration of 1-aminobenzotriazole to guinea pigs.
Topics: Adrenal Glands; Animals; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Guinea Pigs; Microsomes; Mitochondria; Steroids; Triazoles | 1995 |
Selectivity and kinetics of inactivation of rabbit hepatic cytochromes P450 2B4 and 2B5 by N-aralkylated derivatives of 1-aminobenzotriazole.
Topics: Alkylation; Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cytochrome P-450 Enzyme System; Enzyme Activation; Humans; Isoenzymes; Kidney; Kinetics; Liver; Mice; Microsomes, Liver; Phenobarbital; Rabbits; Recombinant Proteins; Steroid Hydroxylases; Triazoles | 1995 |
Contribution of oxidation and deacetylation to the bioactivation of acetaminophen in vitro in liver and kidney from male and female Sprague-Dawley rats.
Topics: Acetaminophen; Animals; Biotransformation; Carbon Radioisotopes; Female; Kidney; Kidney Diseases; Liver; Male; Nitrophenols; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Sex Factors; Triazoles | 1995 |
Inactivation of adrenal cytochromes P450 by 1-aminobenzotriazole. Divergence of in vivo and in vitro actions.
Topics: Adrenal Glands; Animals; Cytochrome P-450 Enzyme Inhibitors; Female; Isoenzymes; Microsomes; Mitochondria; Rats; Rats, Sprague-Dawley; Steroid Hydroxylases; Time Factors; Triazoles | 1995 |
Inhibition of adrenal cytochromes P450 by 1-aminobenzotriazole in vitro. Selectivity for xenobiotic metabolism.
Topics: Adrenal Glands; Animals; Cytochrome P-450 CYP11B2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Guinea Pigs; Male; Microsomes; NADP; Steroid 11-beta-Hydroxylase; Steroid 21-Hydroxylase; Steroid Hydroxylases; Triazoles; Xenobiotics | 1994 |
Bioactivation of arachidonic acid by the cytochrome P450 monooxygenases of guinea pig lung: the orthologue of cytochrome P450 2B4 is solely responsible for formation of epoxyeicosatrienoic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Guinea Pigs; Lung; Male; Metyrapone; Microsomes; Microsomes, Liver; NADP; Phenobarbital; Proadifen; Triazoles | 1994 |
N-aralkylated derivatives of 1-aminobenzotriazole are potent isozyme- and lung-selective mechanism-based inhibitors of guinea pig cytochrome P-450 in vivo.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Enzyme Activation; Guinea Pigs; Isoenzymes; Liver; Lung; Male; Phenobarbital; Sensitivity and Specificity; Triazoles | 1994 |
A 13-week toxicologic and pathologic evaluation of prolonged cytochromes P450 inhibition by 1-aminobenzotriazole in male rats.
Topics: Animals; Body Weight; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Eating; Liver; Male; Microsomes, Liver; Organ Size; Oxidoreductases; Rats; Rats, Inbred Strains; Triazoles | 1994 |
Mechanism-based inactivation of cytochrome P450 1A1 by N-aralkyl-1-aminobenzotriazoles in guinea pig kidney in vivo and in vitro: minimal effects on metabolism of arachidonic acid by renal P450-dependent monooxygenases.
Topics: Animals; Arachidonic Acid; Benzoflavones; beta-Naphthoflavone; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Activation; Guinea Pigs; Kidney; Male; Microsomes; Microsomes, Liver; Oxidoreductases; Oxygenases; Triazoles | 1993 |
Toxicity of precocene II in rat hepatocyte cultures: effects of serum and culture time.
Topics: Animals; Antimetabolites; Benzopyrans; Buthionine Sulfoximine; Cells, Cultured; Culture Media; Culture Media, Serum-Free; Cytochrome P-450 Enzyme Inhibitors; Glutathione; Insecticides; Juvenile Hormones; Liver; Male; Methionine Sulfoximine; Plants; Rats; Time Factors; Triazoles | 1994 |
Distribution of 1-aminobenzotriazole in male rats after administration of an oral dose.
Topics: Administration, Oral; Animals; Biotransformation; Chromatography, High Pressure Liquid; Half-Life; Male; Rats; Tissue Distribution; Triazoles | 1993 |
N-aralkyl derivatives of 1-aminobenzotriazole as potent isozyme-selective mechanism-based inhibitors of rabbit pulmonary cytochrome P450 in vivo.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Isoenzymes; Lung; Male; Microsomes, Liver; Pentobarbital; Rabbits; Substrate Specificity; Triazoles | 1993 |
Protein-reactive metabolites of carbamazepine in mouse liver microsomes.
Topics: Animals; Anticonvulsants; Ascorbic Acid; Caffeic Acids; Carbamazepine; Carbon Monoxide; Catechol O-Methyltransferase; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dioxolanes; Enzyme Inhibitors; Epoxide Hydrolases; Female; Glutathione Transferase; Mice; Mice, Inbred Strains; Microsomes, Liver; NAD(P)H Dehydrogenase (Quinone); NADP; Piperonyl Butoxide; Sulfhydryl Compounds; Triazoles | 1996 |
Inhibition of the contraction of the ductus arteriosus to oxygen by 1-aminobenzotriazole, a mechanism-based inactivator of cytochrome P450.
Topics: Animals; Cyclic GMP; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ductus Arteriosus; Endothelins; Female; Fetus; Guinea Pigs; In Vitro Techniques; Mixed Function Oxygenases; Muscle Contraction; Muscle, Smooth, Vascular; Oxygen; Pregnancy; Sheep; Triazoles; Vasoconstriction | 1996 |
Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells.
Topics: Animals; Antifungal Agents; Calcium Channel Blockers; Carotid Body; Cell Separation; Cells, Cultured; Clotrimazole; Cytochrome P-450 Enzyme Inhibitors; Electric Conductivity; Hypoxia; Imidazoles; Ions; Miconazole; Potassium Channel Blockers; Rats; Rats, Wistar; Reference Values; Triazoles | 1996 |
Mechanism of toxicity of precocene II in rat hepatocyte cultures.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cell Death; Cell Membrane; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Glutathione; Insecticides; L-Lactate Dehydrogenase; Liver; Male; Membrane Potentials; Mitochondria, Liver; Plants; Pyridines; Rats; Sodium-Potassium-Exchanging ATPase; Triazoles | 1995 |
Effects of fatty acids and ketone bodies on cytochromes P450 2B, 4A, and 2E1 expression in primary cultured rat hepatocytes.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Carnitine; Cells, Cultured; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Decanoic Acids; Enzyme Inhibitors; Fatty Acids; Fatty Acids, Unsaturated; Glycerol; Hydroxybutyrates; Ketone Bodies; Liver; Mixed Function Oxygenases; Palmitates; Pyruvic Acid; Rats; RNA, Messenger; Triazoles | 1997 |
Is cytochrome P-450 involved in hypoxic inhibition of K+ currents in rat type I carotid body cells?
Topics: Action Potentials; Animals; Carotid Body; Cell Hypoxia; Cells, Cultured; Clotrimazole; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Hypoxia; Ion Transport; Miconazole; Nerve Tissue Proteins; Patch-Clamp Techniques; Potassium; Potassium Channels; Rats; Triazoles | 1996 |
Metabolism of the cytochrome P450 mechanism-based inhibitor N-benzyl-1-aminobenzotriazole to products that covalently bind with protein in guinea pig liver and lung microsomes: comparative study with 1-aminobenzotriazole.
Topics: Animals; Biotransformation; Carbon Radioisotopes; Cytochrome P-450 Enzyme Inhibitors; Enzyme Activation; Gas Chromatography-Mass Spectrometry; Guinea Pigs; Lung; Male; Microsomes; Microsomes, Liver; Protein Binding; Triazoles | 1997 |
Sinusoidal endothelial cells as a target for acetaminophen toxicity. Direct action versus requirement for hepatocyte activation in different mouse strains.
Topics: Acetaminophen; Animals; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Endothelium; Glutathione; Liver; Male; Mice; Mice, Inbred C3H; Species Specificity; Triazoles | 1997 |
Influence of cytochrome P-450 inhibitors on endothelium-dependent nitro-L-arginine-resistant relaxation and cromakalim-induced relaxation in rat mesenteric arteries.
Topics: Acetylcholine; Animals; Benzopyrans; Biological Factors; Cromakalim; Cytochrome P-450 Enzyme Inhibitors; Fatty Acids, Unsaturated; Female; In Vitro Techniques; Mesenteric Arteries; Miconazole; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Norepinephrine; Proadifen; Pyrroles; Rats; Rats, Wistar; Triazoles; Vasodilator Agents | 1997 |
Coincubation of rat renal proximal tubules with hepatic subcellular fractions potentiates the effects of para-aminophenol.
Topics: Adenine Nucleotides; Aminophenols; Animals; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Female; Glutathione; In Vitro Techniques; Kidney Tubules, Proximal; Liver; Mitochondria, Liver; NADP; Oxidation-Reduction; Oxygen Consumption; Pancreatitis-Associated Proteins; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Triazoles | 1997 |
The contribution of oxidation and deacetylation to acetaminophen nephrotoxicity in female Sprague-Dawley rats.
Topics: Acetaminophen; Acetylation; Analgesics, Non-Narcotic; Animals; Blood Urea Nitrogen; Female; Glutathione; Kidney; Kidney Diseases; Liver; Male; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Sex Characteristics; Triazoles; Tritolyl Phosphates | 1997 |
Inhibition of testicular steroid metabolism by administration of 1-aminobenzotriazole to rats.
Topics: Adrenal Cortex Hormones; Animals; Dose-Response Relationship, Drug; Male; Microsomes; Mitochondria; Rats; Rats, Sprague-Dawley; Steroid 17-alpha-Hydroxylase; Steroids; Testicular Hormones; Triazoles | 1998 |
Glu-320 and Asp-323 are determinants of the CYP4A1 hydroxylation regiospecificity and resistance to inactivation by 1-aminobenzotriazole.
Topics: Amino Acid Substitution; Aspartic Acid; Binding Sites; Catalysis; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Enzyme Activation; Glutamic Acid; Humans; Hydroxylation; Imidazoles; Imines; Mixed Function Oxygenases; Mutagenesis, Site-Directed; Recombinant Proteins; Substrate Specificity; Triazoles | 1998 |
Inhibition of renal arachidonic acid omega-hydroxylase activity with ABT reduces blood pressure in the SHR.
Topics: Animals; Blood Pressure; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Kidney Cortex; Kidney Medulla; Kinetics; Male; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Reference Values; Triazoles | 1998 |
The catalytic site of cytochrome P4504A11 (CYP4A11) and its L131F mutant.
Topics: Amino Acid Sequence; Bacterial Proteins; Binding Sites; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fatty Acids, Omega-3; Humans; Imidazoles; Imines; Mixed Function Oxygenases; Models, Molecular; Molecular Sequence Data; Mutation; NADPH-Ferrihemoprotein Reductase; Recombinant Proteins; Sequence Homology, Amino Acid; Stereoisomerism; Triazoles | 1998 |
The cytochrome P450 suicide inhibitor, 1-aminobenzotriazole, sensitizes rats to zymosan-induced toxicity.
Topics: Animals; Body Weight; Cytochrome P-450 Enzyme Inhibitors; Drug Synergism; Enzyme Inhibitors; Inflammation; Leukocyte Count; Male; Microsomes, Liver; Neutrophils; Nitrates; Nitrites; Organ Size; Rats; Rats, Sprague-Dawley; Survival Analysis; Triazoles; Zymosan | 1998 |
Kinetics of drug metabolism in rat liver slices: IV. Comparison of ethoxycoumarin clearance by liver slices, isolated hepatocytes, and hepatic microsomes from rats pretreated with known modifiers of cytochrome P-450 activity.
Topics: Animals; beta-Naphthoflavone; Cell Separation; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Activation; Enzyme Inhibitors; In Vitro Techniques; Kinetics; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Sprague-Dawley; Triazoles | 1999 |
Inhibitor studies of tabersonine metabolism in C. roseus hairy roots.
Topics: Alkaloids; Clotrimazole; Enzyme Inhibitors; Indole Alkaloids; Indoles; Oxygenases; Plant Roots; Pyridines; Quinolines; Triazoles | 1999 |
Cytochrome CYP sources of N-alkylprotoporphyrin IX after administration of porphyrinogenic xenobiotics to rats.
Topics: Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Glucocorticoids; Male; Microsomes, Liver; NADP; Porphyrins; Protoporphyrins; Rats; Rats, Sprague-Dawley; Sydnones; Triazoles; Xenobiotics | 1999 |
Lack of mechanism-based inactivation of rat hepatic microsomal cytochromes P450 by doxorubicin.
Topics: Animals; Antibiotics, Antineoplastic; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Doxorubicin; Enzyme Activation; Heme; Lipid Peroxidation; Male; Microsomes, Liver; NADH, NADPH Oxidoreductases; Rats; Rats, Inbred F344; Triazoles | 1999 |
The role of polycyclic aromatic hydrocarbon metabolism in dimethylbenz[a]anthracene-induced pre-B lymphocyte apoptosis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Aryl Hydrocarbon Hydroxylases; B-Lymphocytes; Cell Line; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Gene Deletion; Hematopoietic Stem Cells; Ligands; Mice; Models, Biological; Polychlorinated Dibenzodioxins; Polycyclic Aromatic Hydrocarbons; Receptors, Aryl Hydrocarbon; RNA, Messenger; Stromal Cells; Triazoles | 1999 |
Omega-hydroxyceramides are required for corneocyte lipid envelope (CLE) formation and normal epidermal permeability barrier function.
Topics: Administration, Topical; Animals; Ceramides; Epidermal Cells; Epidermis; Homeostasis; Humans; Hydroxylation; Keratinocytes; Lipids; Male; Membrane Proteins; Mice; Mice, Hairless; Nuclear Envelope; Organelles; Permeability; Reference Values; Triazoles | 2000 |
Potentiation of oxygen-induced lung injury in rats by the mechanism-based cytochrome P-450 inhibitor, 1-aminobenzotriazole.
Topics: Animals; Blotting, Western; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Drug Synergism; Enzyme Inhibitors; Hyperoxia; Liver; Male; Microsomes; Oxazines; Oxygen; Pleural Effusion; Protein Isoforms; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Time Factors; Triazoles | 2000 |
1-Aminobenzotriazole inhibits acrylamide-induced dominant lethal effects in spermatids of male mice.
Topics: Acrylamide; Animals; Antimutagenic Agents; Epoxy Compounds; Female; Fertility; Genes, Dominant; Genes, Lethal; Male; Mice; Mutagens; Sperm Motility; Spermatids; Triazoles | 2000 |
Inhibition of cytochrome P450 2E1 decreases, but does not eliminate, genotoxicity mediated by 1,3-butadiene.
Topics: Administration, Inhalation; Animals; Bone Marrow Cells; Butadienes; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Dichloroethylenes; Enzyme Inhibitors; Erythrocytes; Male; Mice; Mice, Inbred Strains; Micronuclei, Chromosome-Defective; Micronucleus Tests; Microsomes, Liver; Models, Biological; Mutagenicity Tests; Mutagens; Triazoles | 2000 |
Inhibition by unsaturated fatty acids of type II secretory phospholipase A2 synthesis in guinea-pig alveolar macrophages evidence for the eicosanoid-independent pathway.
Topics: Animals; Arachidonic Acid; Aspirin; Benzeneacetamides; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Group II Phospholipases A2; Guinea Pigs; Hydroxamic Acids; Inhibitory Concentration 50; Lipoxygenase; Lipoxygenase Inhibitors; Macrophages, Alveolar; Male; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Triazoles; Tumor Necrosis Factor-alpha | 2000 |
Hepatoprotection by dimethyl sulfoxide. III. Role of inhibition of the bioactivation and covalent bonding of chloroform.
Topics: Alanine Transaminase; Allyl Compounds; Animals; Binding Sites; Chemical and Drug Induced Liver Injury; Chloroform; Cytochrome P-450 CYP2E1 Inhibitors; Dimethyl Sulfoxide; Enzyme Inhibitors; Free Radical Scavengers; Liver; Male; Rats; Rats, Sprague-Dawley; Sulfides; Time Factors; Triazoles | 2000 |
Fluorescent HPLC assay for 20-HETE and other P-450 metabolites of arachidonic acid.
Topics: Animals; Arachidonic Acid; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Indicators and Reagents; Kidney Cortex; Microsomes; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Spectrometry, Fluorescence; Triazoles | 2000 |
Inhibition of GABA(A) receptor (GABAR) currents by arachidonic acid in HEK 293 cells stably transfected with alpha1beta2gamma2 GABAR subunits.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Anticonvulsants; Arachidonic Acid; Binding, Competitive; Cells, Cultured; Cyclooxygenase Inhibitors; Diazepam; Dose-Response Relationship, Drug; Fatty Acids; Fatty Acids, Monounsaturated; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Indomethacin; Kidney; Linoleic Acid; Masoprocol; Membrane Potentials; Patch-Clamp Techniques; Pentobarbital; Picrotoxin; Receptors, GABA-A; Recombinant Proteins; Transfection; Triazoles | 2000 |
Angiotensin II-induced hypertension: contribution of Ras GTPase/Mitogen-activated protein kinase and cytochrome P450 metabolites.
Topics: Alkyl and Aryl Transferases; Angiotensin II; Animals; Blood Pressure; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Therapy, Combination; Enzyme Inhibitors; Flavonoids; Hypertension; Kidney; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mixed Function Oxygenases; ras Proteins; Rats; Rats, Sprague-Dawley; Triazoles | 2000 |
Increasing uptake and bioactivation with development positively modulate diazinon toxicity in early life stage medaka (Oryzias latipes).
Topics: Acetylcholinesterase; Age Factors; Animals; Cholinesterase Inhibitors; Cytochrome P-450 Enzyme System; Diazinon; Fishes; Insecticides; Kinetics; Lethal Dose 50; Microsomes, Liver; Organophosphorus Compounds; Oryzias; Piperonyl Butoxide; Sensitivity and Specificity; Time Factors; Triazoles | 2001 |
Cytochrome P-450 metabolite of arachidonic acid mediates bradykinin-induced negative inotropic effect.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Blood Pressure; Bradykinin; Coronary Vessels; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Enzyme Inhibitors; Heart; Heart Rate; In Vitro Techniques; Indomethacin; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Octoxynol; Proadifen; Rats; Rats, Wistar; Tachyphylaxis; Triazoles; Ventricular Function, Left | 2001 |
Role of guanylyl cyclase and cytochrome P-450 on renal response to nitric oxide.
Topics: Acetylcysteine; Amidines; Animals; Blood Pressure; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glomerular Filtration Rate; Guanylate Cyclase; Infusions, Parenteral; Kidney; Male; Methylene Blue; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Rats; Rats, Sprague-Dawley; Renal Circulation; Triazoles | 2001 |
Renal 20-hydroxyeicosatetraenoic acid synthesis during pregnancy.
Topics: Animals; Blood Pressure; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Female; Hydroxyeicosatetraenoic Acids; Isoenzymes; Kidney; Loop of Henle; Microcirculation; Mixed Function Oxygenases; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley; Sodium; Triazoles | 2002 |
Acrylamide-induced cellular transformation.
Topics: Acetylcysteine; Acrylamide; Animals; Buthionine Sulfoximine; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Dose-Response Relationship, Drug; Drug Combinations; Embryo, Mammalian; Enzyme Inhibitors; Glutathione; Mesocricetus; Triazoles | 2002 |
Mechanisms for the induction of oxidative stress in Syrian hamster embryo cells by acrylonitrile.
Topics: Acrylonitrile; Animals; Carcinogens; Catalase; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Dose-Response Relationship, Drug; Drug Synergism; Embryo, Mammalian; Glutathione; Hydroxybenzoates; Hydroxyl Radical; Mesocricetus; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase; Time Factors; Triazoles; Xanthine Oxidase | 2002 |
Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin II.
Topics: Amides; Angiotensin II; Animals; Arachidonic Acid; Blood Pressure; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Mixed Function Oxygenases; Rats; Rats, Sprague-Dawley; Renal Circulation; Sulfones; Triazoles; Vasoconstriction; Vasoconstrictor Agents | 2002 |
Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in rats, dogs, and monkeys.
Topics: Animals; Antipyrine; Cytochrome P-450 Enzyme System; Dogs; Humans; Macaca fascicularis; Male; Metabolic Clearance Rate; Rats; Rats, Sprague-Dawley; Triazoles | 2002 |
3-methylindole-induced toxicity to human bronchial epithelial cell lines.
Topics: Apoptosis; Bronchi; Cell Line, Transformed; Cell Survival; Cytochrome P-450 Enzyme System; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Antagonism; Glutathione; Humans; Isoenzymes; L-Lactate Dehydrogenase; Maleates; Respiratory Mucosa; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skatole; Transfection; Triazoles | 2003 |
Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells.
Topics: Animals; Bronchi; Capsaicin; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Glutathione; Goats; Hepatocytes; Humans; Hydrogenation; Mass Spectrometry; Mice; Microsomes, Liver; Nuclear Magnetic Resonance, Biomolecular; Rabbits; Rats; Triazoles | 2003 |
Cytochrome P450 2E1 (CYP2E1) is the principal enzyme responsible for urethane metabolism: comparative studies using CYP2E1-null and wild-type mice.
Topics: Animals; Carbon Dioxide; Chromatography, High Pressure Liquid; Computer Simulation; Cytochrome P-450 CYP2E1; Feces; Half-Life; Liver; Male; Mice; Mice, Knockout; Models, Biological; Paraoxon; Tissue Distribution; Triazoles; Urethane | 2003 |
Biodegradation of chloronaphthalenes and polycyclic aromatic hydrocarbons by the white-rot fungus Phlebia lindtneri.
Topics: Biodegradation, Environmental; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dioxins; Enzyme Inhibitors; Hydroxylation; Naphthalenes; Oxidation-Reduction; Phenanthrenes; Piperonyl Butoxide; Polycyclic Aromatic Hydrocarbons; Polyporales; Triazoles | 2003 |
The effect of valproic acid on hepatic and plasma levels of 15-F2t-isoprostane in rats.
Topics: Animals; Anticonvulsants; Biotransformation; Cytochrome P-450 Enzyme System; Dinoprost; Enzyme Inhibitors; F2-Isoprostanes; Gas Chromatography-Mass Spectrometry; Lipid Peroxides; Liver; Male; Oxidative Stress; Phenobarbital; Proadifen; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances; Triazoles; Valproic Acid | 2003 |
Concurrent corticosteroid and phenanthrene transformation by filamentous fungus Cunninghamella elegans.
Topics: Biotransformation; Cortodoxone; Cunninghamella; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Metyrapone; Phenanthrenes; Proadifen; Triazoles | 2003 |
Inhibitors of 20-HETE formation promote salt-sensitive hypertension in rats.
Topics: Amidines; Animals; Arachidonic Acid; Blood Pressure; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Rats; Rats, Sprague-Dawley; Sodium Chloride; Triazoles | 2003 |
Studies on the metabolism of the thiofurans furfuryl mercaptan and 2-methyl-3-furanthiol in rat liver.
Topics: Algorithms; Animals; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Furans; Hepatocytes; Kinetics; Liver; Male; Mass Spectrometry; Methyltransferases; Microsomes, Liver; Monoamine Oxidase; NADH, NADPH Oxidoreductases; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Triazoles | 2003 |
The CYP inhibitor 1-aminobenzotriazole does not prevent oxidative stress associated with alcohol-induced liver injury in rats and mice.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Electron Spin Resonance Spectroscopy; Enzyme Induction; Enzyme Inhibitors; Ethanol; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidative Stress; Rats; Rats, Wistar; RNA, Messenger; Triazoles | 2003 |
Cytochrome P-450 inhibition attenuates hypertension induced by reductions in uterine perfusion pressure in pregnant rats.
Topics: Animals; Arachidonic Acids; Blood Pressure; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Female; Hemodynamics; Hypertension; Kidney; Kidney Cortex; Pre-Eclampsia; Pregnancy; Rats; Rats, Sprague-Dawley; Triazoles; Uterus | 2004 |
Inhibition of the formation of EETs and 20-HETE with 1-aminobenzotriazole attenuates pressure natriuresis.
Topics: Animals; Arachidonic Acid; Blood Pressure; Blotting, Western; Centrifugation, Density Gradient; Cytochrome P-450 Enzyme Inhibitors; Eicosanoids; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Immunohistochemistry; Kidney; Kidney Cortex; Male; Natriuresis; Rats; Rats, Sprague-Dawley; Renal Circulation; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Sodium-Potassium-Exchanging ATPase; Triazoles | 2004 |
Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in guinea pigs and mice using serial sampling.
Topics: Animals; Antipyrine; Dose-Response Relationship, Drug; Gas Chromatography-Mass Spectrometry; Guinea Pigs; Male; Metabolic Clearance Rate; Mice; Mice, Inbred C57BL; Triazoles | 2004 |
Endothelial cytochrome P450 contributes to the acetylcholine-induced cardiodepression in isolated rat hearts.
Topics: Acetylcholine; Animals; Blood Pressure; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Enzyme Inhibitors; Heart; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Octoxynol; Organ Culture Techniques; Perfusion; Rats; Rats, Wistar; Triazoles; Vasodilator Agents; Ventricular Function, Left | 2004 |
Subchronic acrylamide treatment induces a tissue-specific increase in DNA synthesis in the rat.
Topics: Acrylamide; Animals; Apoptosis; Bromodeoxyuridine; Cell Division; DNA; Dose-Response Relationship, Drug; Drug Therapy, Combination; Environmental Pollutants; Male; Mitosis; Neoplasms; Organ Specificity; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Triazoles | 2004 |
A role for one or more p450 enzymes in the response to sepsis.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Critical Care; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Intestinal Perforation; Liver; Oxidoreductases, N-Demethylating; Rats; Shock, Septic; Survival Rate; Systemic Inflammatory Response Syndrome; Triazoles | 2005 |
Inhibition of Ca2+/calmodulin-dependent protein kinase II, RAS-GTPase and 20-hydroxyeicosatetraenoic acid attenuates the development of diabetes-induced vascular dysfunction in the rat carotid artery.
Topics: Amidines; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carotid Arteries; Carotid Artery Diseases; Diabetes Mellitus, Experimental; Hydroxyeicosatetraenoic Acids; Monomeric GTP-Binding Proteins; Organophosphonates; Protein Kinase Inhibitors; Rats; Rats, Wistar; Streptozocin; Sulfonamides; Triazoles; Vascular Diseases; Vasoconstriction; Vasodilation | 2005 |
Role of cytochrome P-450 in schisandrin B-induced antioxidant and heat shock responses in mouse liver.
Topics: Administration, Oral; Animals; Antioxidants; Cyclooctanes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Heat-Shock Response; Lignans; Liver; Mice; Mice, Inbred BALB C; Microsomes, Liver; Mitochondria, Liver; NADP; Oxidative Stress; Polycyclic Compounds; Schisandraceae; Triazoles | 2005 |
Cytochrome P-450-dependent metabolism of arachidonic acid in the kidney of rats with diabetes insipidus.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cytochrome P-450 CYP4A; Dehydration; Diabetes Insipidus; Hydroxyeicosatetraenoic Acids; Kidney; Male; Oxytocin; Rats; Rats, Inbred BB; Rats, Long-Evans; Triazoles | 2005 |
Contribution of cytochrome P450 metabolites of arachidonic acid to hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME.
Topics: Animals; Arachidonic Acid; Blood Pressure; Blood Vessels; Collagen Type III; Coronary Vessels; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Isoproterenol; Kidney; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Norepinephrine; Proteinuria; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Splanchnic Circulation; Triazoles; Vasoconstrictor Agents; Vasodilator Agents | 2005 |
Regioselective hydroxylation of adamantane by Streptomyces griseoplanus cells.
Topics: Adamantane; Alcohols; Chromatography, Gas; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Hydroxylation; Magnetic Resonance Spectroscopy; Mass Spectrometry; Streptomyces; Triazoles; Vitamin K 3 | 2006 |
Growth of Phanerochaete chrysosporium on diesel fuel hydrocarbons at neutral pH.
Topics: Alkanes; Biodegradation, Environmental; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Gasoline; Hydrogen-Ion Concentration; Mucor; Phanerochaete; Polycyclic Aromatic Hydrocarbons; Triazoles | 2006 |
In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations in human liver microsomes: a comparison with SKF-525A.
Topics: Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Isoenzymes; Microsomes, Liver; Oxidation-Reduction; Proadifen; Substrate Specificity; Triazoles | 2005 |
Effect of 1-aminobenzotriazole on the in vitro metabolism and single-dose pharmacokinetics of chlorzoxazone, a selective CYP2E1 substrate in Wistar rats.
Topics: Animals; Chlorzoxazone; Cytochrome P-450 CYP2E1; Humans; Kinetics; Male; Microsomes, Liver; Rats; Rats, Wistar; Triazoles | 2005 |
Inhibition by nitric oxide of cytochrome P450 4A activity contributes to endotoxin-induced hypotension in rats.
Topics: Animals; Cytochrome P-450 CYP4A; Endotoxins; Hypotension; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Triazoles | 2006 |
In vivo use of the P450 inactivator 1-aminobenzotriazole in the rat: varied dosing route to elucidate gut and liver contributions to first-pass and systemic clearance.
Topics: Administration, Oral; Animals; Area Under Curve; Biological Availability; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Injections, Intravenous; Intestines; Liver; Male; Rats; Rats, Sprague-Dawley; Triazoles | 2006 |
The effect of cimetidine on dextromethorphan O-demethylase activity of human liver microsomes and recombinant CYP2D6.
Topics: Catalase; Chromatography, High Pressure Liquid; Cimetidine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Dextrorphan; Dose-Response Relationship, Drug; Edetic Acid; Enzyme Inhibitors; Humans; Kinetics; Microsomes, Liver; NADP; Oxidoreductases, O-Demethylating; Quinidine; Recombinant Proteins; Superoxide Dismutase; Triazoles | 2004 |
Nitric oxide/cytochrome P450 interactions in cyclosporin A-induced effects in the rat.
Topics: Amidines; Animals; Arginine; Blood Pressure; Bradykinin; Cyclosporine; Cytochrome P-450 Enzyme System; Endothelin-1; Hydroxyeicosatetraenoic Acids; Kidney; Male; Microsomes; Nitric Oxide; Nitroprusside; Phenylephrine; Rats; Rats, Sprague-Dawley; Triazoles | 2006 |
Effects of quercetin on beta-apo-8'-carotenal-induced DNA damage and cytochrome P1A2 expression in A549 cells.
Topics: Antioxidants; Benzo(a)pyrene; beta Carotene; Blotting, Western; Carotenoids; Cell Line, Tumor; Comet Assay; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; DNA Breaks; Drug Interactions; Enzyme Inhibitors; Humans; Lipid Peroxidation; Lung Neoplasms; Quercetin; Triazoles | 2006 |
Degradation of 2,5-dimethylpyrazine by Rhodococcus erythropolis strain DP-45 isolated from a waste gas treatment plant of a fishmeal processing company.
Topics: Animals; Biodegradation, Environmental; Carbon; Fishes; Flavins; Food Industry; Gases; Industrial Waste; Nitrogen; Oxygen; Phenylhydrazines; Pyrazines; Rhodococcus; Temperature; Triazoles | 2007 |
Elevations in renal interstitial hydrostatic pressure and 20-hydroxyeicosatetraenoic acid contribute to pressure natriuresis.
Topics: Amidines; Animals; Arachidonic Acids; Blood Pressure; Enzyme Inhibitors; Hydrostatic Pressure; Hydroxyeicosatetraenoic Acids; Kidney Cortex; Male; Natriuresis; Rats; Triazoles | 2007 |
Cytochrome P-450 monooxygenases in control of renal haemodynamics and arterial pressure in anaesthetized rats.
Topics: Amidines; Animals; Arachidonic Acid; Blood Pressure; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Hemodynamics; Hydroxyeicosatetraenoic Acids; Kidney; Kidney Cortex; Kidney Medulla; Laser-Doppler Flowmetry; Male; Nitric Oxide; Rats; Rats, Wistar; Renal Circulation; Triazoles; Vasoconstrictor Agents; Vasodilation | 2006 |
Effects of ATP on rat renal haemodynamics and excretion: role of sodium intake, nitric oxide and cytochrome P450.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Kidney; Kidney Cortex; Kidney Medulla; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Osmolar Concentration; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Rats; Rats, Wistar; Renal Circulation; Sodium; Sodium, Dietary; Triazoles; Vascular Resistance | 2007 |
Mechanistics of trichloroethylene mineralization by the white-rot fungus Trametes versicolor.
Topics: Carbon Dioxide; Chlorides; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ethylene Chlorohydrin; Laccase; Polyporales; Triazoles; Trichloroethylene; Water Pollutants, Chemical | 2008 |
Neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase.
Topics: Administration, Oral; Aniline Compounds; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Proliferation; Dogs; Drug Synergism; Mice; Molecular Structure; Neoplasms; Quinazolines; Rats; Receptor, ErbB-2; Triazoles; Xenograft Model Antitumor Assays | 2007 |
Importance of mechanistic drug metabolism studies in support of drug discovery: A case study with an N -sulfonylated dipeptide VLA-4 antagonist in rats.
Topics: Animals; Cells, Cultured; Cyclosporine; Dogs; Inactivation, Metabolic; Integrin alpha4beta1; Microsomes, Liver; Organic Anion Transporters, Sodium-Independent; Phenylalanine; Rats; Rats, Sprague-Dawley; Solute Carrier Organic Anion Transporter Family Member 1B3; Time Factors; Triazoles | 2008 |
Demonstration of the metabolic pathway responsible for nevirapine-induced skin rash.
Topics: Animals; Chromatography, Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Exanthema; Female; Male; Microsomes, Liver; Molecular Structure; Nevirapine; Oxidation-Reduction; Rats; Rats, Inbred BN; Rats, Inbred Lew; Sensitivity and Specificity; Skin; Stereoisomerism; Tandem Mass Spectrometry; Triazoles | 2008 |
Nonenzymatic formation of a novel hydroxylated sulfamethoxazole derivative in human liver microsomes: implications for bioanalysis of sulfamethoxazole metabolites.
Topics: Ascorbic Acid; Chromatography, High Pressure Liquid; Deferoxamine; Edetic Acid; Enzyme Inhibitors; Ferrous Compounds; Humans; Hydrogen Peroxide; Hydroxylation; Kinetics; Microsomes, Liver; Molecular Structure; NADP; Sulfamethoxazole; Tandem Mass Spectrometry; Triazoles | 2008 |
Is 1-aminobenzotriazole an appropriate in vitro tool as a nonspecific cytochrome P450 inactivator?
Topics: Chromatography, Liquid; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Humans; Spectrophotometry, Ultraviolet; Tandem Mass Spectrometry; Triazoles | 2009 |
Validation of the use of nonnaive surgically catheterized rats for pharmacokinetics studies.
Topics: Animals; Antipyrine; Catheterization; Cost-Benefit Analysis; Femoral Artery; Hematocrit; Jugular Veins; Male; Pharmacokinetics; Quinidine; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Surgical Procedures, Operative; Terfenadine; Time Factors; Triazoles | 2008 |
Role of 20-hydroxyeicosatetraenoic acid in altering vascular reactivity in diabetes.
Topics: Amidines; Angiotensin II; Animals; Blood Glucose; Body Weight; Carbachol; Cytochrome P-450 CYP4A; Diabetes Mellitus, Experimental; Endothelin-1; Enzyme Inhibitors; Histamine; Hydroxyeicosatetraenoic Acids; Kidney; Male; Mesenteric Arteries; Microsomes; Nitroprusside; Norepinephrine; Perfusion; Rats; Rats, Wistar; Renal Artery; Triazoles; Vasoconstriction; Vasodilation | 2009 |
The use of 1-aminobenzotriazole in differentiating the role of CYP-mediated first pass metabolism and absorption in limiting drug oral bioavailability: a case study.
Topics: Administration, Oral; Animals; Biological Availability; Chromatography, Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Half-Life; Injections, Intravenous; Male; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Tissue Distribution; Triazoles | 2008 |
Human cytochrome P450 2E1 and sulfotransferase 1A1 coexpressed in Chinese hamster V79 cells enhance spontaneous mutagenesis.
Topics: Animals; Arylsulfotransferase; Cell Line; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Enzyme Inhibitors; Genetic Engineering; Genetic Vectors; Humans; Mutagenesis; Recombinant Fusion Proteins; Triazoles | 2010 |
Differential action of bradykinin on intrarenal regional perfusion in the rat: waning effect in the cortex and major impact in the medulla.
Topics: Animals; Bradykinin; Clotrimazole; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Kidney Cortex; Kidney Medulla; Male; Models, Animal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Potassium Channels, Calcium-Activated; Rats; Rats, Wistar; Regional Blood Flow; Triazoles; Vasodilator Agents | 2009 |
Antioxidants vitamin E and 1-aminobenzotriazole prevent experimental non-alcoholic steatohepatitis in mice.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; bcl-2-Associated X Protein; Blotting, Western; Cyclooxygenase 2; Fatty Liver; Genes, bcl-2; Inflammation; Lipid Peroxidation; Male; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; NF-kappa B p50 Subunit; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor beta1; Triazoles; Vitamin E | 2009 |
Biotransformation of beta-myrcene to geraniol by a strain of Rhodococcus erythropolis isolated by selective enrichment from hop plants.
Topics: Acyclic Monoterpenes; Aerobiosis; Bacterial Proteins; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Humulus; Mass Spectrometry; Metyrapone; Monoterpenes; Proteome; Rhodococcus; Soil Microbiology; Terpenes; Triazoles | 2010 |
Biodegradation of the analgesic naproxen by Trametes versicolor and identification of intermediates using HPLC-DAD-MS and NMR.
Topics: Aliivibrio fischeri; Analgesics; Biodegradation, Environmental; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Laccase; Magnetic Resonance Spectroscopy; Mass Spectrometry; Metabolic Networks and Pathways; Naproxen; Time Factors; Toxicity Tests; Trametes; Triazoles | 2010 |
Investigation of the intestinal permeability and first-pass metabolism of drugs in cynomolgus monkeys using single-pass intestinal perfusion.
Topics: Administration, Oral; Animals; Antipyrine; Biological Availability; Cytochrome P-450 Enzyme Inhibitors; Inactivation, Metabolic; Intestinal Absorption; Intestinal Mucosa; Macaca fascicularis; Perfusion; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Reference Values; Triazoles | 2010 |
Removal of diclofenac and mefenamic acid by the white rot fungus Phanerochaete sordida YK-624 and identification of their metabolites after fungal transformation.
Topics: Biodegradation, Environmental; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Diclofenac; Enzyme Inhibitors; Mefenamic Acid; Phanerochaete; Triazoles | 2010 |
Utility of the carboxylesterase inhibitor bis-para-nitrophenylphosphate (BNPP) in the plasma unbound fraction determination for a hydrolytically unstable amide derivative and agonist of the TGR5 receptor.
Topics: Animals; Carboxylesterase; Dogs; Drug Stability; Female; Humans; Hydrolysis; Isoquinolines; Male; Mice; Microsomes, Liver; NADP; Nitrophenols; Organophosphorus Compounds; Oxidation-Reduction; Quinolines; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Triazoles | 2010 |
20-HETE mediates ozone-induced, neutrophil-independent airway hyper-responsiveness in mice.
Topics: Animals; Bronchial Hyperreactivity; Carbachol; Hydroxyeicosatetraenoic Acids; Lipid Peroxidation; Male; Mass Spectrometry; Mice; Mice, Inbred BALB C; Neutrophils; Ozone; Respiratory Hypersensitivity; Triazoles | 2010 |
Derivatization of the azole 1-aminobenzotriazole using laccase of Pycnoporus cinnabarinus and Myceliophthora thermophila: influence of methanol on the reaction and biological evaluation of the derivatives.
Topics: Bacillus subtilis; Cell Line, Tumor; Cell Proliferation; Gentisates; Humans; Laccase; Methanol; Microbial Sensitivity Tests; Mitosporic Fungi; Pycnoporus; Staphylococcus aureus; Triazoles | 2010 |
Induction of CYP2B6 and CYP3A4 expression by 1-aminobenzotriazole (ABT) in human hepatocytes.
Topics: Aryl Hydrocarbon Hydroxylases; Constitutive Androstane Receptor; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Enzyme Induction; Gene Expression Regulation, Enzymologic; Hep G2 Cells; Hepatocytes; Humans; Oxidoreductases, N-Demethylating; Oximes; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Rifampin; RNA, Messenger; Thiazoles; Transcriptional Activation; Transfection; Triazoles | 2010 |
Ticlopidine-induced hepatotoxicity in a GSH-depleted rat model.
Topics: Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Glutathione; Platelet Aggregation Inhibitors; Protein Binding; Rats; Ticlopidine; Triazoles | 2011 |
An oxygenase inhibitor study in Solanum lycopersicum combined with metabolite profiling analysis revealed a potent peroxygenase inactivator.
Topics: Enzyme Inhibitors; Flavonoids; Fruit; Metabolic Networks and Pathways; Metabolome; Mixed Function Oxygenases; Plant Proteins; Solanum lycopersicum; Triazoles | 2011 |
Dual effects of estrogen on vascular smooth muscle cells: receptor-mediated proliferative vs. metabolite-induced pro-senescent actions.
Topics: Animals; Cell Proliferation; Cellular Senescence; DNA Damage; Estradiol; Female; Fulvestrant; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Estrogen; Triazoles | 2011 |
Postmenopausal hypertension: role of 20-HETE.
Topics: Aging; Animals; Blood Pressure; Cytochrome P-450 CYP4A; Disease Models, Animal; Female; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Postmenopause; Rats; Rats, Inbred SHR; Triazoles | 2011 |
Determination of metabolic profile of anti-malarial trioxane CDRI 99/411 in rat liver microsomes using HPLC.
Topics: Animals; Antimalarials; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Heterocyclic Compounds; Humans; Ketoconazole; Kinetics; Male; Metabolome; Microsomes, Liver; Nonlinear Dynamics; Rats; Rats, Sprague-Dawley; Spiro Compounds; Triazoles | 2012 |
Hepatic cytochrome P450s attenuate the cytotoxicity induced by leflunomide and its active metabolite A77 1726 in primary cultured rat hepatocytes.
Topics: Aniline Compounds; Animals; Benzoflavones; Biomarkers; Cell Survival; Cells, Cultured; Crotonates; Cytochrome P-450 Enzyme System; Hepatocytes; Hydroxybutyrates; Inactivation, Metabolic; Isoxazoles; Ketoconazole; Leflunomide; Liver; Male; Nitriles; Primary Cell Culture; Proadifen; Rats; Rats, Sprague-Dawley; Ticlopidine; Toluidines; Triazoles | 2011 |
1-Aminobenzotriazole, a known cytochrome P450 inhibitor, is a substrate and inhibitor of N-acetyltransferase.
Topics: Acetaminophen; Acetylation; Animals; Arylamine N-Acetyltransferase; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Glucuronosyltransferase; Humans; Isoenzymes; Male; Microsomes, Liver; Procainamide; Rats; Rats, Sprague-Dawley; Sulfotransferases; Triazoles; Umbelliferones | 2011 |
Higher throughput human hepatocyte assays for the evaluation of time-dependent inhibition of CYP3A4.
Topics: Adult; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Design; Enzyme Inhibitors; Erythromycin; Female; Hepatocytes; High-Throughput Screening Assays; Humans; Inhibitory Concentration 50; Ketoconazole; Male; Middle Aged; Time Factors; Triazoles; Young Adult | 2011 |
Effects of CYP inhibitors on precocene I metabolism and toxicity in rat liver slices.
Topics: Adenosine Triphosphate; Animals; Aspartate Aminotransferases; Benzopyrans; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ditiocarb; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Glucuronides; Glutathione; Hydroxylation; Ketoconazole; L-Lactate Dehydrogenase; Liver; Male; Mass Spectrometry; Molecular Structure; Necrosis; Rats; Rats, Sprague-Dawley; Sulfaphenazole; Tranylcypromine; Triazoles | 2011 |
Absorption, translocation and metabolism of metamitron in Chenopodium album.
Topics: Adsorption; Chenopodium album; Herbicide Resistance; Herbicides; Picolinic Acids; Piperonyl Butoxide; Plant Leaves; Plant Roots; Triazines; Triazoles | 2012 |
Degradation of the antibiotics norfloxacin and ciprofloxacin by a white-rot fungus and identification of degradation products.
Topics: Anti-Bacterial Agents; Biodegradation, Environmental; Biotechnology; Biotransformation; Chromatography, Liquid; Ciprofloxacin; Dimerization; Laccase; Mass Spectrometry; Models, Chemical; Norfloxacin; Oxygen; Tandem Mass Spectrometry; Technology, Pharmaceutical; Time Factors; Trametes; Triazoles | 2011 |
The genotoxic potential of methapyrilene using the alkaline Comet assay in vitro and in vivo.
Topics: Animals; Comet Assay; DNA Damage; Female; Glutathione; Hepatocytes; Histamine H1 Antagonists; Liver; Male; Methapyrilene; Mutagenicity Tests; Oxidative Stress; Rats; Rats, Wistar; Sex Factors; Superoxide Dismutase; Triazoles | 2011 |
Differential modulation of cytochrome P450 activity and the effect of 1-aminobenzotriazole on hepatic transport in sandwich-cultured human hepatocytes.
Topics: Anti-Anxiety Agents; Anticholesteremic Agents; Atorvastatin; Bile; Biological Transport; Cell Survival; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fluorobenzenes; Hepatocytes; Heptanoic Acids; Humans; Isoenzymes; Midazolam; Models, Biological; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Sulfonamides; Time Factors; Triazoles | 2012 |
Vestibular toxicity of cis-2-pentenenitrile in the rat.
Topics: Animals; Behavior, Animal; Body Weight; Central Nervous System; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Activation; Epithelium; Fluoresceins; Fluorescent Dyes; Hair Cells, Auditory; Male; Microscopy, Electron, Scanning; Motor Activity; Nitriles; Rats; Rats, Long-Evans; Triazoles; Vestibular Diseases; Vestibule, Labyrinth | 2012 |
Inhibitors of 20-hydroxyeicosatetraenoic acid (20-HETE) formation attenuate the natriuretic effect of dopamine.
Topics: Amidines; Animals; Cytochrome P-450 CYP4A; Dopamine; Glomerular Filtration Rate; Hydroxyeicosatetraenoic Acids; Kidney Cortex; Liver; Male; Natriuretic Agents; Rats; Rats, Inbred Dahl; Rats, Sprague-Dawley; Triazoles | 2012 |
Definition of metabolism-dependent xenobiotic toxicity with co-cultures of human hepatocytes and mouse 3T3 fibroblasts in the novel integrated discrete multiple organ co-culture (IdMOC) experimental system: results with model toxicants aflatoxin B1, cyclo
Topics: 3T3 Cells; Acetals; Aflatoxin B1; Animals; Coculture Techniques; Cyclophosphamide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fibroblasts; Firefly Luciferin; Hepatocytes; Humans; Inactivation, Metabolic; Inhibitory Concentration 50; Mice; Tamoxifen; Toxicity Tests; Triazoles; Xenobiotics | 2012 |
[Metabolic detoxification of bakuchiol is mediated by cytochrome P450 enzymes in human liver microsomes].
Topics: Cell Line; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Inactivation, Metabolic; Kidney Tubules, Proximal; Microsomes, Liver; Phenols; Triazoles | 2012 |
Assessment of the role of in situ generated (E)-2,4-diene-valproic acid in the toxicity of valproic acid and (E)-2-ene-valproic acid in sandwich-cultured rat hepatocytes.
Topics: Animals; Cell Culture Techniques; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Hepatocytes; Male; Molecular Structure; Phenobarbital; Rats; Rats, Sprague-Dawley; Triazoles; Valproic Acid | 2012 |
Evaluation of metabolism and disposition of GDC-0152 in rats using 14C labeling strategy at two different positions: a novel formation of hippuric acid from 4-phenyl-5-amino-1,2,3-thiadiazole.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Autoradiography; Bile; Biotransformation; Carbon Radioisotopes; Cyclohexanes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Feces; Female; Half-Life; Hepatocytes; Hippurates; Hydrolysis; Injections, Intravenous; Isotope Labeling; Male; Mass Spectrometry; Metabolic Clearance Rate; Molecular Structure; Oxidation-Reduction; Pyrroles; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Tissue Distribution; Triazoles | 2013 |
Presystemic metabolism of AZ'0908, a novel mPGES-1 inhibitor: an in vitro and in vivo cross-species comparison.
Topics: Animals; Benzamides; Biological Availability; Caco-2 Cells; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dogs; Female; Humans; Intestinal Mucosa; Intramolecular Oxidoreductases; Liver; Male; Metabolic Clearance Rate; Microsomes; Prostaglandin-E Synthases; Rats; Rats, Sprague-Dawley; Sulfonamides; Triazoles | 2013 |
Inhibition of cytochromes P450 and the hydroxylation of 4-monochlorobiphenyl in whole poplar.
Topics: Biphenyl Compounds; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Environmental Pollutants; Enzyme Inhibitors; Fatty Acids, Unsaturated; Populus; Triazoles | 2013 |
Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human.
Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Animals; Catechols; Cell Line, Tumor; Chemoprevention; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dogs; Gas Chromatography-Mass Spectrometry; Glycyrrhetinic Acid; Haplorhini; Humans; Magnetic Resonance Spectroscopy; Mice; Microsomes, Liver; Plant Extracts; Rats; Rats, Sprague-Dawley; Triazoles; Zingiber officinale | 2013 |
Effects of cytochrome P450 inhibitors on peroxidase activity.
Topics: Benzoflavones; Cytochrome P-450 Enzyme Inhibitors; Disulfiram; Ditiocarb; Ellipticines; Enzyme Activation; Enzyme Inhibitors; Horseradish Peroxidase; Humans; Ketoconazole; Metyrapone; Piperonyl Butoxide; Proadifen; Quinidine; Structure-Activity Relationship; Substrate Specificity; Sulfaphenazole; Triazoles; Troleandomycin | 2012 |
Involvement of extracellular and intracellular enzymes of Ceriporia sp. ZLY-2010 for biodegradation of polychlorinated biphenyls (PCBs).
Topics: Aroclors; Biodegradation, Environmental; Coriolaceae; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Laccase; Peroxidases; Polychlorinated Biphenyls; Triazoles | 2013 |
20-Hydroxyeicosatetraenoic acid inhibition attenuates balloon injury-induced neointima formation and vascular remodeling in rat carotid arteries.
Topics: Amidines; Angioplasty, Balloon, Coronary; Animals; Carotid Artery Injuries; Carotid Artery, Common; Carotid Stenosis; Cell Movement; Cell Proliferation; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Disease Models, Animal; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Hyperplasia; Male; Muscle, Smooth, Vascular; Neointima; Rats; Rats, Sprague-Dawley; Triazoles; Tunica Intima | 2013 |
Metabolic pathways leading to detoxification of triptolide, a major active component of the herbal medicine Tripterygium wilfordii.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Buthionine Sulfoximine; Cysteine; Cytochrome P-450 Enzyme System; Dipeptides; Diterpenes; Enzyme Inhibitors; Epoxy Compounds; Glutathione; Humans; Inactivation, Metabolic; Male; Metabolic Networks and Pathways; Mice; Microsomes, Liver; NADP; Phenanthrenes; Plants, Medicinal; Triazoles; Tripterygium | 2014 |
Hepatobiliary and intestinal elimination of darunavir in an integrated preclinical rat model.
Topics: Animals; Area Under Curve; Caco-2 Cells; Cell Membrane Permeability; Cells, Cultured; Darunavir; Hepatobiliary Elimination; Hepatocytes; Humans; Infusions, Intravenous; Intestinal Elimination; Liver; Male; Models, Animal; Rats, Sprague-Dawley; Reproducibility of Results; Sulfonamides; Triazoles | 2014 |
1-Aminobenzotriazole coincubated with (S)-warfarin results in potent inactivation of CYP2C9.
Topics: Binding Sites; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C9; Diclofenac; Female; Humans; In Vitro Techniques; Male; Microsomes, Liver; Molecular Docking Simulation; Molecular Structure; Protein Binding; Substrate Specificity; Tandem Mass Spectrometry; Time Factors; Triazoles; Warfarin | 2014 |
Contribution of cytochrome P450 and UDT-glucuronosyltransferase to the metabolism of drugs containing carboxylic acid groups: risk assessment of acylglucuronides using human hepatocytes.
Topics: Camphanes; Carboxylic Acids; Cytochrome P-450 Enzyme System; Glucuronides; Glucuronosyltransferase; Half-Life; Hepatocytes; Humans; Inactivation, Metabolic; Liver; Reference Standards; Risk Assessment; Substrate Specificity; Triazoles | 2014 |
1-Aminobenzotriazole modulates oral drug pharmacokinetics through cytochrome P450 inhibition and delay of gastric emptying in rats.
Topics: Administration, Oral; Animals; Cytochrome P-450 Enzyme Inhibitors; Female; Gastric Emptying; Rats; Rats, Sprague-Dawley; Rats, Wistar; Triazoles | 2014 |
An in vitro digestion test that reflects rat intestinal conditions to probe the importance of formulation digestion vs first pass metabolism in Danazol bioavailability from lipid based formulations.
Topics: Administration, Oral; Animals; Biological Availability; Chemistry, Pharmaceutical; Danazol; Digestion; Dogs; Drug Carriers; Drug Delivery Systems; Duodenum; Estrogen Antagonists; In Vitro Techniques; Intestinal Absorption; Intestines; Lipids; Rats; Solubility; Tissue Distribution; Triazoles | 2014 |
Evaluation of matrix microsampling methods for therapeutic drug candidate quantification in discovery-stage rodent pharmacokinetic studies.
Topics: Animals; Benzothiazoles; Blood Specimen Collection; Chromatography, High Pressure Liquid; Drug Discovery; Male; Mice; Pharmacokinetics; Pyrimidines; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Triazoles | 2014 |
Using improved serial blood sampling method of mice to study pharmacokinetics and drug-drug interaction.
Topics: Administration, Intravenous; Administration, Oral; Animals; Antipyrine; Biological Availability; Blood Specimen Collection; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Drug Monitoring; Ibuprofen; Male; Mice, Inbred C57BL; Models, Animal; Organic Anion Transporters; Pravastatin; Reproducibility of Results; Rifampin; Tail; Terfenadine; Triazoles; Veins | 2015 |
Establishment of a mouse model for amiodarone-induced liver injury and analyses of its hepatotoxic mechanism.
Topics: Alanine Transaminase; Amiodarone; Animals; Chemical and Drug Induced Liver Injury; Dexamethasone; Gadolinium; Ketoconazole; Kupffer Cells; Male; Mice; Mice, Inbred BALB C; Models, Animal; Triazoles | 2016 |
High salt intake increases blood pressure in normal rats: putative role of 20-HETE and no evidence on changes in renal vascular reactivity.
Topics: Acetylcholine; Animals; Arterial Pressure; Blood Pressure; Epoxide Hydrolases; Hydroxyeicosatetraenoic Acids; Male; Nitric Oxide; Norepinephrine; Osmolar Concentration; Rats; Rats, Wistar; Renal Circulation; Sodium, Dietary; Triazoles | 2015 |
Cytochrome P450 Inhibitors Reduce Creeping Bentgrass (Agrostis stolonifera) Tolerance to Topramezone.
Topics: Adaptation, Physiological; Agrostis; Biomass; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Herbicides; Malathion; Pyrazoles; Quinolines; Triazoles | 2015 |
In Vitro and In Vivo Mechanistic Studies toward Understanding the Role of 1-Aminobenzotriazole in Rat Drug-Drug Interactions.
Topics: Animals; Drug Interactions; Gastric Emptying; Male; Metoprolol; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Triazoles | 2015 |
Human CYP2E1-dependent mutagenicity of mono- and dichlorobiphenyls in Chinese hamster (V79)-derived cells.
Topics: Animals; Arylsulfotransferase; Cell Line; Cricetinae; Cricetulus; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Environmental Pollutants; Humans; Hydroxylation; Mutagens; Polychlorinated Biphenyls; Triazoles | 2016 |
In vitro and in vivo characterization of CYP inhibition by 1-aminobenzotriazole in rats.
Topics: Administration, Intravenous; Administration, Oral; Animals; Cytochrome P-450 Enzyme Inhibitors; Hepatocytes; Male; Microsomes, Liver; Midazolam; Rats; Triazoles | 2016 |
Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity.
Topics: Administration, Oral; Aldehyde Oxidase; Animals; Area Under Curve; Benzamides; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Male; Metabolic Clearance Rate; Microsomes, Liver; Rats, Sprague-Dawley; Risk Assessment; Substrate Specificity; Thiazoles; Triazoles | 2016 |
Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat.
Topics: Animals; Catecholamine Plasma Membrane Transport Proteins; Female; Liver; Male; Mice; Mice, Knockout; Organic Cation Transport Proteins; p21-Activated Kinases; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Triazoles | 2016 |
Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4).
Topics: Allosteric Regulation; Animals; Microsomes, Liver; Picolinic Acids; Pyrroles; Rats; Receptors, Metabotropic Glutamate; Structure-Activity Relationship; Sulfonamides; Triazoles | 2016 |
Application of Osmotic Pumps for Sustained Release of 1-Aminobenzotriazole and Inhibition of Cytochrome P450 Enzymes in Mice: Model Comparison with the Hepatic P450 Reductase Null Mouse.
Topics: Animals; Antipyrine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Genotype; Infusion Pumps, Implantable; Infusions, Subcutaneous; Injections, Subcutaneous; Liver; Male; Mice, Knockout; Osmotic Pressure; Phenotype; Triazoles | 2016 |
In vivo use of the CYP inhibitor 1-aminobenzotriazole to increase long-term exposure in mice.
Topics: Animals; Antipyrine; Cytochrome P-450 Enzyme Inhibitors; Male; Mice, Inbred C57BL; Osmosis; Triazoles | 2016 |
Preliminary characterization of a murine model for 1-bromopropane neurotoxicity: Role of cytochrome P450.
Topics: Animals; Atmosphere Exposure Chambers; Cerebral Cortex; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disease Models, Animal; Dose-Response Relationship, Drug; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Hydrocarbons, Brominated; Injections, Intraperitoneal; Injections, Subcutaneous; Liver; Male; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurons; Neurotoxicity Syndromes; Organ Size; ran GTP-Binding Protein; Solvents; Triazoles | 2016 |
Intracellular Unbound Atorvastatin Concentrations in the Presence of Metabolism and Transport.
Topics: Animals; Atorvastatin; Biological Transport; Cell Membrane; Diffusion; Intracellular Space; Liver; Male; Models, Biological; Rats; Rats, Sprague-Dawley; Rifampin; Triazoles | 2016 |
Quantitative analysis of pharmacokinetic profiles of verapamil and drug-drug interactions induced by a CYP inhibitor using a stable isotope-labeled compound.
Topics: Administration, Intravenous; Administration, Oral; Animals; Biological Availability; Cytochrome P-450 Enzyme Inhibitors; Deuterium; Drug Interactions; Male; Microsomes, Liver; Rats, Wistar; Triazoles; Verapamil | 2016 |
Characterization of 1-Aminobenzotriazole and Ketoconazole as Novel Inhibitors of Monoamine Oxidase (MAO): An In Vitro Investigation.
Topics: Animals; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Humans; Isoenzymes; Ketoconazole; Kinetics; Liver; Mice; Microsomes, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rats; Triazoles | 2017 |
Acetaminophen analog N-acetyl-m-aminophenol, but not its reactive metabolite, N-acetyl-p-benzoquinone imine induces CYP3A activity via inhibition of protein degradation.
Topics: Acetaminophen; Acetylcysteine; Animals; Benzoquinones; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Gene Expression Regulation; Glutathione; Hepatocytes; Imines; Male; Primary Cell Culture; Protein Stability; Proteolysis; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Triazoles | 2017 |
In Vitro Metabolism of Oprozomib, an Oral Proteasome Inhibitor: Role of Epoxide Hydrolases and Cytochrome P450s.
Topics: Administration, Oral; Adult; Chlorpromazine; Cytochrome P-450 Enzyme System; Drug Interactions; Epoxide Hydrolases; Female; Half-Life; Hepatocytes; Humans; Male; Microsomes, Liver; Middle Aged; Oxidation-Reduction; Proteasome Inhibitors; Recombinant Proteins; Triazoles; Young Adult | 2017 |
Metabolic Activation of Cholestatic Drug-Induced Bile Acid-Dependent Toxicity in Human Sandwich-Cultured Hepatocytes.
Topics: Activation, Metabolic; Animals; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Bile Acids and Salts; Biological Transport; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cholestasis; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Hepatocytes; Humans; Male; Rats; Rats, Sprague-Dawley; Tolvaptan; Toxicity Tests; Triazoles | 2017 |
CYP-Mediated Sulfoximine Deimination of AZD6738.
Topics: Ataxia Telangiectasia Mutated Proteins; Citrullination; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Female; Humans; Indoles; Male; Microsomes, Liver; Morpholines; Oxidation-Reduction; Oxygenases; Protein Kinase Inhibitors; Pyrimidines; Sulfonamides; Sulfoxides; Triazoles | 2017 |
A cell-based assay using HepaRG cells for predicting drug-induced phospholipidosis.
Topics: Amikacin; Amiodarone; Amitriptyline; Biological Assay; Chlorpromazine; Female; Hep G2 Cells; Humans; Imipramine; Lipidoses; Loratadine; Phospholipids; Predictive Value of Tests; Triazoles | 2017 |
Evaluation of the pharmacokinetic-pharmacodynamic relationship of praziquantel in the Schistosoma mansoni mouse model.
Topics: Animals; Anthelmintics; Chemoprevention; Chromatography, Liquid; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Mice; Plasma; Praziquantel; Schistosoma mansoni; Schistosomiasis mansoni; Tandem Mass Spectrometry; Time Factors; Triazoles | 2017 |
Chemical suppressors of
Topics: Agriculture; Agrochemicals; Brefeldin A; DDT; Deoxyglucose; Disease Resistance; Hordeum; Plant Proteins; Ribonucleosides; Spermidine; Triazoles | 2017 |
Utility of food pellets containing 1-aminobenzotriazole for longer term in vivo inhibition of cytochrome P450 in mice.
Topics: Administration, Oral; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Mice; Oxazoles; Pyrazoles; Triazoles | 2019 |
Methoxsalen as an in vitro phenotyping tool in comparison with 1-aminobenzotriazole.
Topics: Clopidogrel; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Methoxsalen; Microsomes, Liver; Phenotype; Protein Isoforms; Triazoles | 2019 |
Evaluation of diuron tolerance and biotransformation by the white-rot fungus Ganoderma lucidum.
Topics: Biotransformation; Catalase; Diuron; Drug Resistance, Fungal; Herbicides; Laccase; Pentanones; Piperonyl Butoxide; Reactive Oxygen Species; Reishi; Superoxide Dismutase; Triazoles | 2018 |
Effect of pretreatment regimens of 1-aminobenzotriazole on metabolism and gastric emptying of probe compounds in rat.
Topics: Acetaminophen; Administration, Oral; Animals; Area Under Curve; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Gastric Emptying; Male; Rats; Rats, Sprague-Dawley; Triazolam; Triazoles | 2019 |
Cyhalothrin biodegradation in Cunninghamella elegans.
Topics: Biodegradation, Environmental; Cunninghamella; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Hydroxylation; Insecticides; Magnetic Resonance Spectroscopy; Nitriles; Pyrethrins; Triazoles | 2019 |
Fate of 6:2 fluorotelomer sulfonic acid in pumpkin (Cucurbita maxima L.) based on hydroponic culture: Uptake, translocation and biotransformation.
Topics: Alkanesulfonates; Alkanesulfonic Acids; Biodegradation, Environmental; Biological Transport; Biotransformation; Caproates; Cucurbita; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fluorocarbons; Heptanoic Acids; Hydrophobic and Hydrophilic Interactions; Hydroponics; Pentanoic Acids; Sulfonic Acids; Triazoles; Trifluoroacetic Acid | 2019 |
Short-term toxicity study of 1-aminobenzotraizole, a CYP inhibitor, in Wistar rats.
Topics: Animals; Body Weight; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Female; Male; Organ Size; Rats; Rats, Wistar; Toxicity Tests; Triazoles | 2022 |
Case Study 9: Probe-Dependent Binding Explains Lack of CYP2C9 Inactivation by 1-Aminobenzotriazole (ABT).
Topics: Binding Sites; Crystallography, X-Ray; Cytochrome P-450 CYP2C9; Diclofenac; Drug Interactions; Gene Silencing; Humans; Models, Molecular; Molecular Docking Simulation; Protein Conformation; Time Factors; Triazoles; Warfarin | 2021 |