thioacetanilide: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
ID Source | ID |
---|---|
PubMed CID | 820777 |
CHEMBL ID | 3740596 |
SCHEMBL ID | 340780 |
SCHEMBL ID | 14160916 |
MeSH ID | M0118568 |
Synonym |
---|
l9al2go03y , |
unii-l9al2go03y |
n-phenylthioacetamide |
ethanethioamide, n-phenyl- |
637-53-6 |
nsc-36984 |
usaf ek-1902 |
thioacetanilide |
acetanilide, thio- |
nsc36984 |
wln: suy1&mr |
einecs 211-288-4 |
nsc 36984 |
ai3-00235 |
brn 2205727 |
AQ-012/40221353 |
n-phenylethanethioamide |
thioacetanilide, 98% |
FT-0693782 |
T0188 |
thioacetanilide [inci] |
SCHEMBL340780 |
SCHEMBL14160916 |
DTXSID1060920 |
n-phenylethanethioamide # |
AKOS025117063 |
CHEMBL3740596 , |
mfcd00004942 |
bdbm50499816 |
AS-41624 |
Q27282872 |
n-phenyl-thioacetamide |
SB75793 |
CS-0107756 |
Excerpt | Reference | Relevance |
---|---|---|
" Extensive SAR investigation led to potent compounds, with nanomolar activity on K103N, and orally bioavailable in rats." | ( Tetrazole thioacetanilides: potent non-nucleoside inhibitors of WT HIV reverse transcriptase and its K103N mutant. Kinzel, OD; Laufer, R; Miller, MD; Moyer, G; Munshi, V; Muraglia, E; Orvieto, F; Palumbi, MC; Pescatore, G; Rowley, M; Summa, V; Williams, PD, 2006) | 0.74 |
Excerpt | Relevance | Reference |
---|---|---|
" Following intragastric dosage (100 mg/kg), over 90% dose was excreted in urine, predominantly as conjugated metabolites: less than 7% was recovered in the faeces, consisting of unchanged thioacetanilide." | ( The metabolism of thioacetanilide in the rat. Trennery, PN; Waring, RH, 1983) | 0.79 |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Polyphenol oxidase 2 | Agaricus bisporus | IC50 (µMol) | 4.1000 | 0.0340 | 3.9871 | 10.0000 | AID1265266 |
Polyphenol oxidase 2 | Agaricus bisporus | Ki | 1.2000 | 0.0006 | 3.2883 | 8.8900 | AID1265267 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Taste receptor type 2 member 38 | Homo sapiens (human) | EC50 (µMol) | 18.0000 | 0.0049 | 1.3610 | 2.3000 | AID1619468 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Taste receptor type 2 member 38 | Homo sapiens (human) | Activity | 3.0000 | 0.1500 | 3.2563 | 10.0000 | AID1619467 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Process | via Protein(s) | Taxonomy |
---|---|---|
detection of chemical stimulus involved in sensory perception of bitter taste | Taste receptor type 2 member 38 | Homo sapiens (human) |
G protein-coupled receptor signaling pathway | Taste receptor type 2 member 38 | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Process | via Protein(s) | Taxonomy |
---|---|---|
G protein-coupled receptor activity | Taste receptor type 2 member 38 | Homo sapiens (human) |
bitter taste receptor activity | Taste receptor type 2 member 38 | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Process | via Protein(s) | Taxonomy |
---|---|---|
plasma membrane | Taste receptor type 2 member 38 | Homo sapiens (human) |
membrane | Taste receptor type 2 member 38 | Homo sapiens (human) |
membrane | Taste receptor type 2 member 38 | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID1265274 | Inhibition of tyrosinase in mouse B16F10 cell lysates using DOPA as substrate relative to control | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Analogues of ethionamide, a drug used for multidrug-resistant tuberculosis, exhibit potent inhibition of tyrosinase. |
AID1265267 | Competitive inhibition of mushroom tyrosinase using L-tyrosine as substrate by Lineweaver-Burk plots analysis | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Analogues of ethionamide, a drug used for multidrug-resistant tuberculosis, exhibit potent inhibition of tyrosinase. |
AID1265270 | Cytotoxicity against mouse B16F10 cells assessed as cell survival at 50 uM after 48 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Analogues of ethionamide, a drug used for multidrug-resistant tuberculosis, exhibit potent inhibition of tyrosinase. |
AID1265272 | Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction of melanin production at 20 uM relative to control | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Analogues of ethionamide, a drug used for multidrug-resistant tuberculosis, exhibit potent inhibition of tyrosinase. |
AID1265266 | Inhibition of mushroom tyrosinase using L-tyrosine as substrate | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Analogues of ethionamide, a drug used for multidrug-resistant tuberculosis, exhibit potent inhibition of tyrosinase. |
AID1265271 | Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction of melanin production at 10 uM relative to control | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Analogues of ethionamide, a drug used for multidrug-resistant tuberculosis, exhibit potent inhibition of tyrosinase. |
AID1265269 | Binding affinity to mushroom tyrosinase assessed as fluorescence quenching | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Analogues of ethionamide, a drug used for multidrug-resistant tuberculosis, exhibit potent inhibition of tyrosinase. |
AID1265273 | Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction of melanin production at 50 uM relative to control | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Analogues of ethionamide, a drug used for multidrug-resistant tuberculosis, exhibit potent inhibition of tyrosinase. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 2 (13.33) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 6 (40.00) | 29.6817 |
2010's | 7 (46.67) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (16.78) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 1 (6.67%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 14 (93.33%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |