| Assay ID | Title | Year | Journal | Article |
|---|
| AID1288622 | Reversal of P-gp-mediated resistance to adriamycin in human K562/A02 cells assessed as adriamycin IC50 at 5 uM after 48 hrs by MTT assay (Rvb = 38.02 +/- 1.65 uM) | 2016 | Bioorganic & medicinal chemistry, 05-15, Volume: 24, Issue:10
| Design, synthesis and biological evaluation of LBM-A5 derivatives as potent P-glycoprotein-mediated multidrug resistance inhibitors. |
| AID326367 | Inhibition of human Pgp in A2780 cells after 30 mins by Hoechst 33342 assay | 2008 | Bioorganic & medicinal chemistry, Mar-01, Volume: 16, Issue:5
| Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. |
| AID451987 | Inhibition of BCRP expressed in MCF7 MX cells by Hoechst 33342 staining | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| Novel lead for potent inhibitors of breast cancer resistance protein (BCRP). |
| AID1481909 | Effect on plasma concentration of doxorubicin in Sprague-Dawley rat at 5 mg/kg, iv co-administered with doxorubicin measured after 8 hrs by LC-MS/MS analysis | 2017 | Journal of medicinal chemistry, 04-27, Volume: 60, Issue:8
| Design, Synthesis, and Pharmacological Characterization of N-(4-(2 (6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)yl)ethyl)phenyl)quinazolin-4-amine Derivatives: Novel Inhibitors Reversing P-Glycoprotein-Mediated Multidrug Resistance. |
| AID1481890 | Inhibition of P-gp in human K562/A02 cells assessed as accumulation of doxorubicin at 0.1 uM to 5.0 uM after 150 mins by fluorescence spectrophotometric analysis | 2017 | Journal of medicinal chemistry, 04-27, Volume: 60, Issue:8
| Design, Synthesis, and Pharmacological Characterization of N-(4-(2 (6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)yl)ethyl)phenyl)quinazolin-4-amine Derivatives: Novel Inhibitors Reversing P-Glycoprotein-Mediated Multidrug Resistance. |
| AID1481868 | Cytotoxicity against human K562 cells assessed as cell viability at 1.0 uM after 48 hrs by MTT assay (Rvb = >99%) | 2017 | Journal of medicinal chemistry, 04-27, Volume: 60, Issue:8
| Design, Synthesis, and Pharmacological Characterization of N-(4-(2 (6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)yl)ethyl)phenyl)quinazolin-4-amine Derivatives: Novel Inhibitors Reversing P-Glycoprotein-Mediated Multidrug Resistance. |
| AID364884 | Inhibition of P-gp in human adriamycin-resistant A2780 cells by Hoechst 33342 assay | 2008 | Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
| Structure-activity relationships of new inhibitors of breast cancer resistance protein (ABCG2). |
| AID1481872 | Inhibition of P-gp in human K562/A02 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring fold reduction in doxorubicin IC50 at 1.0 uM after 48 hrs by MTT assay relative to doxorubicin alone | 2017 | Journal of medicinal chemistry, 04-27, Volume: 60, Issue:8
| Design, Synthesis, and Pharmacological Characterization of N-(4-(2 (6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)yl)ethyl)phenyl)quinazolin-4-amine Derivatives: Novel Inhibitors Reversing P-Glycoprotein-Mediated Multidrug Resistance. |
| AID310122 | Inhibition of P-glycoprotein by Hoechst assay | 2007 | Bioorganic & medicinal chemistry, Dec-01, Volume: 15, Issue:23
| New functional assay of P-glycoprotein activity using Hoechst 33342. |
| AID1288623 | Reversal of P-gp-mediated resistance to adriamycin in human K562/A02 cells assessed as reduction in adriamycin IC50 at 5 uM after 48 hrs by MTT assay relative to control | 2016 | Bioorganic & medicinal chemistry, 05-15, Volume: 24, Issue:10
| Design, synthesis and biological evaluation of LBM-A5 derivatives as potent P-glycoprotein-mediated multidrug resistance inhibitors. |
| AID310121 | Inhibition of P-glycoprotein expressed in MDCK-MDR1 cells by calcein AM assay | 2007 | Bioorganic & medicinal chemistry, Dec-01, Volume: 15, Issue:23
| New functional assay of P-glycoprotein activity using Hoechst 33342. |
| AID1481869 | Cytotoxicity against human K562/A02 cells assessed as cell viability at 1.0 uM after 48 hrs by MTT assay (Rvb = >99%) | 2017 | Journal of medicinal chemistry, 04-27, Volume: 60, Issue:8
| Design, Synthesis, and Pharmacological Characterization of N-(4-(2 (6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)yl)ethyl)phenyl)quinazolin-4-amine Derivatives: Novel Inhibitors Reversing P-Glycoprotein-Mediated Multidrug Resistance. |
| AID451989 | Inhibition of MRP1 assessed as calcein AM accumulation by fluorescence assay | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| Novel lead for potent inhibitors of breast cancer resistance protein (BCRP). |
| AID1288621 | Cytotoxicity against human K562/A02 cells assessed as cell viability after 48 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry, 05-15, Volume: 24, Issue:10
| Design, synthesis and biological evaluation of LBM-A5 derivatives as potent P-glycoprotein-mediated multidrug resistance inhibitors. |
| AID451988 | Inhibition of BCRP expressed in MDCK cells by pheophorbide A assay | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| Novel lead for potent inhibitors of breast cancer resistance protein (BCRP). |
| AID1288620 | Cytotoxicity against human K562 cells assessed as cell viability after 48 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry, 05-15, Volume: 24, Issue:10
| Design, synthesis and biological evaluation of LBM-A5 derivatives as potent P-glycoprotein-mediated multidrug resistance inhibitors. |
| AID326368 | Inhibition of human Pgp in A2780 cells after 30 mins by calcein AM assay | 2008 | Bioorganic & medicinal chemistry, Mar-01, Volume: 16, Issue:5
| Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. |
| AID1481893 | Inhibition of ATPase activity in human P-gp membrane fraction at 0.5 uM in presence of ATP after 1 hr by luciferase reporter gene assay | 2017 | Journal of medicinal chemistry, 04-27, Volume: 60, Issue:8
| Design, Synthesis, and Pharmacological Characterization of N-(4-(2 (6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)yl)ethyl)phenyl)quinazolin-4-amine Derivatives: Novel Inhibitors Reversing P-Glycoprotein-Mediated Multidrug Resistance. |
| AID1481891 | Inhibition of P-gp mediated efflux in human K562/A02 cells assessed as intracellular Rh123 accumulation at 1.0 uM measure up to 90 mins by flow cytometric analysis | 2017 | Journal of medicinal chemistry, 04-27, Volume: 60, Issue:8
| Design, Synthesis, and Pharmacological Characterization of N-(4-(2 (6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)yl)ethyl)phenyl)quinazolin-4-amine Derivatives: Novel Inhibitors Reversing P-Glycoprotein-Mediated Multidrug Resistance. |
| AID310120 | Inhibition of P-glycoprotein expressed in A2780/ADR cells by calcein AM assay | 2007 | Bioorganic & medicinal chemistry, Dec-01, Volume: 15, Issue:23
| New functional assay of P-glycoprotein activity using Hoechst 33342. |
| AID364887 | Inhibition of ABCG2 in human mitoxantrone-resistant MCF7 cells by Hoechst 33342 assay | 2008 | Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
| Structure-activity relationships of new inhibitors of breast cancer resistance protein (ABCG2). |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |